-- dump date   	20140620_001242
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
767029000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
767029000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
767029000003	Walker A motif; other site
767029000004	ATP binding site [chemical binding]; other site
767029000005	Walker B motif; other site
767029000006	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
767029000007	DnaA box-binding interface [nucleotide binding]; other site
767029000008	DNA polymerase III subunit beta; Validated; Region: PRK07761
767029000009	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
767029000010	putative DNA binding surface [nucleotide binding]; other site
767029000011	dimer interface [polypeptide binding]; other site
767029000012	beta-clamp/clamp loader binding surface; other site
767029000013	beta-clamp/translesion DNA polymerase binding surface; other site
767029000014	recombination protein F; Reviewed; Region: recF; PRK00064
767029000015	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
767029000016	Walker A/P-loop; other site
767029000017	ATP binding site [chemical binding]; other site
767029000018	Q-loop/lid; other site
767029000019	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029000020	ABC transporter signature motif; other site
767029000021	Walker B; other site
767029000022	D-loop; other site
767029000023	H-loop/switch region; other site
767029000024	Protein of unknown function (DUF721); Region: DUF721; cl02324
767029000025	Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834
767029000026	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
767029000027	putative active site [active]
767029000028	V-type ATP synthase subunit E; Provisional; Region: PRK01005
767029000029	CAAX protease self-immunity; Region: Abi; pfam02517
767029000030	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
767029000031	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029000032	Mg2+ binding site [ion binding]; other site
767029000033	G-X-G motif; other site
767029000034	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
767029000035	anchoring element; other site
767029000036	dimer interface [polypeptide binding]; other site
767029000037	ATP binding site [chemical binding]; other site
767029000038	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
767029000039	active site
767029000040	metal binding site [ion binding]; metal-binding site
767029000041	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
767029000042	DNA gyrase subunit A; Validated; Region: PRK05560
767029000043	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
767029000044	CAP-like domain; other site
767029000045	active site
767029000046	primary dimer interface [polypeptide binding]; other site
767029000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
767029000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
767029000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
767029000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
767029000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
767029000052	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
767029000053	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
767029000054	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029000055	putative substrate translocation pore; other site
767029000056	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
767029000057	dimerization interface [polypeptide binding]; other site
767029000058	putative DNA binding site [nucleotide binding]; other site
767029000059	putative Zn2+ binding site [ion binding]; other site
767029000060	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
767029000061	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
767029000062	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
767029000063	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029000064	dimer interface [polypeptide binding]; other site
767029000065	conserved gate region; other site
767029000066	putative PBP binding loops; other site
767029000067	ABC-ATPase subunit interface; other site
767029000068	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
767029000069	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029000070	dimer interface [polypeptide binding]; other site
767029000071	conserved gate region; other site
767029000072	putative PBP binding loops; other site
767029000073	ABC-ATPase subunit interface; other site
767029000074	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
767029000075	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
767029000076	ABC-ATPase subunit  interface; other site
767029000077	dimer interface [polypeptide binding]; other site
767029000078	putative PBP binding regions; other site
767029000079	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
767029000080	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
767029000081	ABC-ATPase subunit  interface; other site
767029000082	dimer interface [polypeptide binding]; other site
767029000083	putative PBP binding regions; other site
767029000084	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
767029000085	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
767029000086	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
767029000087	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
767029000088	intersubunit interface [polypeptide binding]; other site
767029000089	Predicted transcriptional regulators [Transcription]; Region: COG1695
767029000090	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
767029000091	Fructosamine kinase; Region: Fructosamin_kin; cl17579
767029000092	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
767029000093	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
767029000094	ligand binding site [chemical binding]; other site
767029000095	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
767029000096	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
767029000097	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
767029000098	active site
767029000099	motif I; other site
767029000100	motif II; other site
767029000101	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
767029000102	motif II; other site
767029000103	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
767029000104	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
767029000105	Walker A/P-loop; other site
767029000106	ATP binding site [chemical binding]; other site
767029000107	Q-loop/lid; other site
767029000108	ABC transporter signature motif; other site
767029000109	Walker B; other site
767029000110	D-loop; other site
767029000111	H-loop/switch region; other site
767029000112	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
767029000113	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
767029000114	Walker A/P-loop; other site
767029000115	ATP binding site [chemical binding]; other site
767029000116	Q-loop/lid; other site
767029000117	ABC transporter signature motif; other site
767029000118	Walker B; other site
767029000119	D-loop; other site
767029000120	H-loop/switch region; other site
767029000121	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
767029000122	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
767029000123	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
767029000124	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
767029000125	catalytic residues [active]
767029000126	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
767029000127	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
767029000128	active site
767029000129	ADP/pyrophosphate binding site [chemical binding]; other site
767029000130	dimerization interface [polypeptide binding]; other site
767029000131	allosteric effector site; other site
767029000132	fructose-1,6-bisphosphate binding site; other site
767029000133	Flavodoxin domain; Region: Flavodoxin_5; pfam12724
767029000134	Predicted transcriptional regulators [Transcription]; Region: COG1695
767029000135	Transcriptional regulator PadR-like family; Region: PadR; cl17335
767029000136	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
767029000137	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029000138	Walker A/P-loop; other site
767029000139	ATP binding site [chemical binding]; other site
767029000140	Q-loop/lid; other site
767029000141	ABC transporter signature motif; other site
767029000142	Walker B; other site
767029000143	D-loop; other site
767029000144	H-loop/switch region; other site
767029000145	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
767029000146	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
767029000147	Helix-turn-helix domain; Region: HTH_17; cl17695
767029000148	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
767029000149	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
767029000150	Walker A/P-loop; other site
767029000151	ATP binding site [chemical binding]; other site
767029000152	Q-loop/lid; other site
767029000153	ABC transporter signature motif; other site
767029000154	Walker B; other site
767029000155	D-loop; other site
767029000156	H-loop/switch region; other site
767029000157	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029000158	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029000159	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
767029000160	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
767029000161	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166
767029000162	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
767029000163	putative ligand binding site [chemical binding]; other site
767029000164	putative NAD binding site [chemical binding]; other site
767029000165	catalytic site [active]
767029000166	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
767029000167	ferrous iron transporter FeoB; Region: feoB; TIGR00437
767029000168	G1 box; other site
767029000169	GTP/Mg2+ binding site [chemical binding]; other site
767029000170	Switch I region; other site
767029000171	G2 box; other site
767029000172	G3 box; other site
767029000173	Switch II region; other site
767029000174	G4 box; other site
767029000175	G5 box; other site
767029000176	Nucleoside recognition; Region: Gate; pfam07670
767029000177	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
767029000178	Nucleoside recognition; Region: Gate; pfam07670
767029000179	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
767029000180	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
767029000181	G1 box; other site
767029000182	GTP/Mg2+ binding site [chemical binding]; other site
767029000183	Switch I region; other site
767029000184	G2 box; other site
767029000185	G3 box; other site
767029000186	Switch II region; other site
767029000187	G4 box; other site
767029000188	G5 box; other site
767029000189	Nucleoside recognition; Region: Gate; pfam07670
767029000190	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
767029000191	Nucleoside recognition; Region: Gate; pfam07670
767029000192	NifU-like domain; Region: NifU; cl00484
767029000193	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
767029000194	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
767029000195	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
767029000196	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
767029000197	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
767029000198	active site
767029000199	motif I; other site
767029000200	motif II; other site
767029000201	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
767029000202	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
767029000203	NADPH bind site [chemical binding]; other site
767029000204	putative FMN binding site [chemical binding]; other site
767029000205	YcaO-like family; Region: YcaO; pfam02624
767029000206	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
767029000207	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
767029000208	intersubunit interface [polypeptide binding]; other site
767029000209	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029000210	Major Facilitator Superfamily; Region: MFS_1; pfam07690
767029000211	putative substrate translocation pore; other site
767029000212	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
767029000213	putative DNA binding site [nucleotide binding]; other site
767029000214	putative Zn2+ binding site [ion binding]; other site
767029000215	ATP-grasp domain; Region: ATP-grasp_4; cl17255
767029000216	Protein of unknown function (DUF817); Region: DUF817; pfam05675
767029000217	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
767029000218	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
767029000219	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
767029000220	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
767029000221	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
767029000222	putative active site [active]
767029000223	homotetrameric interface [polypeptide binding]; other site
767029000224	metal binding site [ion binding]; metal-binding site
767029000225	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
767029000226	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
767029000227	FOG: WD40 repeat [General function prediction only]; Region: COG2319
767029000228	structural tetrad; other site
767029000229	SWIM zinc finger; Region: SWIM; pfam04434
767029000230	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
767029000231	MarR family; Region: MarR_2; pfam12802
767029000232	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
767029000233	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
767029000234	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
767029000235	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
767029000236	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
767029000237	catalytic site [active]
767029000238	active site
767029000239	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
767029000240	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
767029000241	active site
767029000242	catalytic site [active]
767029000243	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
767029000244	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
767029000245	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
767029000246	active site
767029000247	NTP binding site [chemical binding]; other site
767029000248	metal binding triad [ion binding]; metal-binding site
767029000249	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
767029000250	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
767029000251	Zn2+ binding site [ion binding]; other site
767029000252	Mg2+ binding site [ion binding]; other site
767029000253	Methyltransferase domain; Region: Methyltransf_23; pfam13489
767029000254	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
767029000255	S-adenosylmethionine binding site [chemical binding]; other site
767029000256	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
767029000257	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029000258	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
767029000259	Walker A/P-loop; other site
767029000260	ATP binding site [chemical binding]; other site
767029000261	Q-loop/lid; other site
767029000262	ABC transporter signature motif; other site
767029000263	Walker B; other site
767029000264	D-loop; other site
767029000265	H-loop/switch region; other site
767029000266	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
767029000267	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
767029000268	membrane-bound complex binding site; other site
767029000269	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
767029000270	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
767029000271	putative ligand binding residues [chemical binding]; other site
767029000272	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
767029000273	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
767029000274	Walker A/P-loop; other site
767029000275	ATP binding site [chemical binding]; other site
767029000276	Q-loop/lid; other site
767029000277	ABC transporter signature motif; other site
767029000278	Walker B; other site
767029000279	D-loop; other site
767029000280	H-loop/switch region; other site
767029000281	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
767029000282	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
767029000283	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
767029000284	ABC-ATPase subunit  interface; other site
767029000285	dimer interface [polypeptide binding]; other site
767029000286	putative PBP binding regions; other site
767029000287	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
767029000288	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
767029000289	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
767029000290	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
767029000291	active site
767029000292	catalytic site [active]
767029000293	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029000294	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029000295	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
767029000296	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
767029000297	active site
767029000298	catalytic tetrad [active]
767029000299	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
767029000300	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
767029000301	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
767029000302	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
767029000303	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
767029000304	DNA interaction; other site
767029000305	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
767029000306	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
767029000307	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
767029000308	Transaldolase; Region: Transaldolase; pfam00923
767029000309	catalytic residue [active]
767029000310	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029000311	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029000312	active site
767029000313	phosphorylation site [posttranslational modification]
767029000314	intermolecular recognition site; other site
767029000315	dimerization interface [polypeptide binding]; other site
767029000316	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029000317	DNA binding residues [nucleotide binding]
767029000318	dimerization interface [polypeptide binding]; other site
767029000319	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
767029000320	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
767029000321	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
767029000322	Walker A/P-loop; other site
767029000323	ATP binding site [chemical binding]; other site
767029000324	Q-loop/lid; other site
767029000325	ABC transporter signature motif; other site
767029000326	Walker B; other site
767029000327	D-loop; other site
767029000328	H-loop/switch region; other site
767029000329	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
767029000330	Histidine kinase; Region: HisKA_3; pfam07730
767029000331	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
767029000332	Type-A lantibiotic; Region: L_biotic_typeA; pfam04604
767029000333	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
767029000334	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
767029000335	DNA-binding site [nucleotide binding]; DNA binding site
767029000336	UTRA domain; Region: UTRA; pfam07702
767029000337	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
767029000338	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
767029000339	substrate binding site [chemical binding]; other site
767029000340	ATP binding site [chemical binding]; other site
767029000341	KduI/IolB family; Region: KduI; pfam04962
767029000342	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
767029000343	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
767029000344	PYR/PP interface [polypeptide binding]; other site
767029000345	dimer interface [polypeptide binding]; other site
767029000346	TPP binding site [chemical binding]; other site
767029000347	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
767029000348	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
767029000349	TPP-binding site; other site
767029000350	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
767029000351	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
767029000352	Walker A/P-loop; other site
767029000353	ATP binding site [chemical binding]; other site
767029000354	Q-loop/lid; other site
767029000355	ABC transporter signature motif; other site
767029000356	Walker B; other site
767029000357	D-loop; other site
767029000358	H-loop/switch region; other site
767029000359	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
767029000360	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
767029000361	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
767029000362	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
767029000363	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
767029000364	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029000365	dimer interface [polypeptide binding]; other site
767029000366	conserved gate region; other site
767029000367	putative PBP binding loops; other site
767029000368	ABC-ATPase subunit interface; other site
767029000369	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
767029000370	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029000371	dimer interface [polypeptide binding]; other site
767029000372	conserved gate region; other site
767029000373	putative PBP binding loops; other site
767029000374	ABC-ATPase subunit interface; other site
767029000375	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
767029000376	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
767029000377	Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337
767029000378	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
767029000379	active site
767029000380	NTP binding site [chemical binding]; other site
767029000381	metal binding triad [ion binding]; metal-binding site
767029000382	antibiotic binding site [chemical binding]; other site
767029000383	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
767029000384	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
767029000385	Coenzyme A binding pocket [chemical binding]; other site
767029000386	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
767029000387	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
767029000388	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
767029000389	FMN binding site [chemical binding]; other site
767029000390	active site
767029000391	substrate binding site [chemical binding]; other site
767029000392	catalytic residue [active]
767029000393	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
767029000394	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
767029000395	DXD motif; other site
767029000396	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
767029000397	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
767029000398	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
767029000399	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
767029000400	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
767029000401	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
767029000402	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
767029000403	Walker A/P-loop; other site
767029000404	ATP binding site [chemical binding]; other site
767029000405	Q-loop/lid; other site
767029000406	ABC transporter signature motif; other site
767029000407	Walker B; other site
767029000408	D-loop; other site
767029000409	H-loop/switch region; other site
767029000410	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
767029000411	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
767029000412	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
767029000413	TM-ABC transporter signature motif; other site
767029000414	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
767029000415	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
767029000416	ligand binding site [chemical binding]; other site
767029000417	Transcriptional regulators [Transcription]; Region: PurR; COG1609
767029000418	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
767029000419	DNA binding site [nucleotide binding]
767029000420	domain linker motif; other site
767029000421	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
767029000422	ligand binding site [chemical binding]; other site
767029000423	dimerization interface [polypeptide binding]; other site
767029000424	Transcriptional regulators [Transcription]; Region: PurR; COG1609
767029000425	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
767029000426	DNA binding site [nucleotide binding]
767029000427	domain linker motif; other site
767029000428	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
767029000429	dimerization interface [polypeptide binding]; other site
767029000430	ligand binding site [chemical binding]; other site
767029000431	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
767029000432	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
767029000433	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
767029000434	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
767029000435	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
767029000436	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
767029000437	Walker A/P-loop; other site
767029000438	ATP binding site [chemical binding]; other site
767029000439	Q-loop/lid; other site
767029000440	ABC transporter signature motif; other site
767029000441	Walker B; other site
767029000442	D-loop; other site
767029000443	H-loop/switch region; other site
767029000444	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
767029000445	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
767029000446	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
767029000447	TM-ABC transporter signature motif; other site
767029000448	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
767029000449	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
767029000450	putative ligand binding site [chemical binding]; other site
767029000451	hypothetical protein; Validated; Region: PRK02101
767029000452	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
767029000453	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
767029000454	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
767029000455	colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005
767029000456	putative ADP-binding pocket [chemical binding]; other site
767029000457	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
767029000458	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
767029000459	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
767029000460	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
767029000461	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029000462	Walker A/P-loop; other site
767029000463	ATP binding site [chemical binding]; other site
767029000464	Q-loop/lid; other site
767029000465	ABC transporter signature motif; other site
767029000466	Walker B; other site
767029000467	D-loop; other site
767029000468	H-loop/switch region; other site
767029000469	Phosphotransferase enzyme family; Region: APH; pfam01636
767029000470	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
767029000471	substrate binding site [chemical binding]; other site
767029000472	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
767029000473	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
767029000474	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
767029000475	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
767029000476	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
767029000477	dimerization interface [polypeptide binding]; other site
767029000478	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
767029000479	dimer interface [polypeptide binding]; other site
767029000480	phosphorylation site [posttranslational modification]
767029000481	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029000482	ATP binding site [chemical binding]; other site
767029000483	Mg2+ binding site [ion binding]; other site
767029000484	G-X-G motif; other site
767029000485	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
767029000486	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029000487	active site
767029000488	phosphorylation site [posttranslational modification]
767029000489	intermolecular recognition site; other site
767029000490	dimerization interface [polypeptide binding]; other site
767029000491	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
767029000492	DNA binding site [nucleotide binding]
767029000493	Domain of unknown function (DUF222); Region: DUF222; pfam02720
767029000494	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
767029000495	TPR motif; other site
767029000496	binding surface
767029000497	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
767029000498	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
767029000499	TPR motif; other site
767029000500	binding surface
767029000501	14-3-3 domain; Region: 14-3-3; cl02098
767029000502	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
767029000503	TPR motif; other site
767029000504	binding surface
767029000505	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
767029000506	TPR motif; other site
767029000507	binding surface
767029000508	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
767029000509	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
767029000510	tetrameric interface [polypeptide binding]; other site
767029000511	NAD binding site [chemical binding]; other site
767029000512	catalytic residues [active]
767029000513	Protein of unknown function (DUF690); Region: DUF690; cl04939
767029000514	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817
767029000515	Proteins of 100 residues with WXG; Region: WXG100; cl02005
767029000516	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
767029000517	RDD family; Region: RDD; pfam06271
767029000518	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
767029000519	phosphopeptide binding site; other site
767029000520	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
767029000521	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
767029000522	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
767029000523	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
767029000524	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
767029000525	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
767029000526	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
767029000527	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
767029000528	Walker A/P-loop; other site
767029000529	ATP binding site [chemical binding]; other site
767029000530	Q-loop/lid; other site
767029000531	ABC transporter signature motif; other site
767029000532	Walker B; other site
767029000533	D-loop; other site
767029000534	H-loop/switch region; other site
767029000535	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
767029000536	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
767029000537	Walker A/P-loop; other site
767029000538	ATP binding site [chemical binding]; other site
767029000539	Q-loop/lid; other site
767029000540	ABC transporter signature motif; other site
767029000541	Walker B; other site
767029000542	D-loop; other site
767029000543	H-loop/switch region; other site
767029000544	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
767029000545	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
767029000546	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
767029000547	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
767029000548	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
767029000549	active site
767029000550	metal binding site [ion binding]; metal-binding site
767029000551	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
767029000552	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
767029000553	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
767029000554	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
767029000555	Walker A/P-loop; other site
767029000556	ATP binding site [chemical binding]; other site
767029000557	Q-loop/lid; other site
767029000558	ABC transporter signature motif; other site
767029000559	Walker B; other site
767029000560	D-loop; other site
767029000561	H-loop/switch region; other site
767029000562	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029000563	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029000564	CRISPR-associated protein; Region: TIGR03986
767029000565	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
767029000566	CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700
767029000567	HipA N-terminal domain; Region: Couple_hipA; cl11853
767029000568	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
767029000569	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
767029000570	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
767029000571	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
767029000572	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
767029000573	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH10; cd08263
767029000574	putative NAD(P) binding site [chemical binding]; other site
767029000575	catalytic Zn binding site [ion binding]; other site
767029000576	structural Zn binding site [ion binding]; other site
767029000577	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
767029000578	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
767029000579	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
767029000580	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
767029000581	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
767029000582	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
767029000583	L-fuculokinase; Provisional; Region: PRK10331
767029000584	uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779
767029000585	putative N- and C-terminal domain interface [polypeptide binding]; other site
767029000586	putative active site [active]
767029000587	MgATP binding site [chemical binding]; other site
767029000588	catalytic site [active]
767029000589	metal binding site [ion binding]; metal-binding site
767029000590	putative carbohydrate binding site [chemical binding]; other site
767029000591	Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834
767029000592	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
767029000593	Walker B motif; other site
767029000594	ATP binding site [chemical binding]; other site
767029000595	DNA binding loops [nucleotide binding]
767029000596	hypothetical protein; Provisional; Region: PRK07236
767029000597	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029000598	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029000599	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
767029000600	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029000601	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
767029000602	Walker A/P-loop; other site
767029000603	ATP binding site [chemical binding]; other site
767029000604	Q-loop/lid; other site
767029000605	ABC transporter signature motif; other site
767029000606	Walker B; other site
767029000607	D-loop; other site
767029000608	H-loop/switch region; other site
767029000609	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
767029000610	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
767029000611	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029000612	Walker A/P-loop; other site
767029000613	ATP binding site [chemical binding]; other site
767029000614	Q-loop/lid; other site
767029000615	ABC transporter signature motif; other site
767029000616	Walker B; other site
767029000617	D-loop; other site
767029000618	H-loop/switch region; other site
767029000619	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
767029000620	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
767029000621	Walker A/P-loop; other site
767029000622	ATP binding site [chemical binding]; other site
767029000623	Q-loop/lid; other site
767029000624	ABC transporter signature motif; other site
767029000625	Walker B; other site
767029000626	D-loop; other site
767029000627	H-loop/switch region; other site
767029000628	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
767029000629	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
767029000630	Walker A/P-loop; other site
767029000631	ATP binding site [chemical binding]; other site
767029000632	Q-loop/lid; other site
767029000633	ABC transporter signature motif; other site
767029000634	Walker B; other site
767029000635	D-loop; other site
767029000636	H-loop/switch region; other site
767029000637	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
767029000638	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819
767029000639	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
767029000640	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
767029000641	Walker A/P-loop; other site
767029000642	ATP binding site [chemical binding]; other site
767029000643	Q-loop/lid; other site
767029000644	ABC transporter signature motif; other site
767029000645	Walker B; other site
767029000646	D-loop; other site
767029000647	H-loop/switch region; other site
767029000648	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
767029000649	Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226
767029000650	Walker A/P-loop; other site
767029000651	ATP binding site [chemical binding]; other site
767029000652	Q-loop/lid; other site
767029000653	ABC transporter signature motif; other site
767029000654	Walker B; other site
767029000655	D-loop; other site
767029000656	H-loop/switch region; other site
767029000657	replicative DNA helicase; Region: DnaB; TIGR00665
767029000658	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
767029000659	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
767029000660	Walker A motif; other site
767029000661	ATP binding site [chemical binding]; other site
767029000662	Walker B motif; other site
767029000663	DNA binding loops [nucleotide binding]
767029000664	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
767029000665	putative homodimer interface [polypeptide binding]; other site
767029000666	putative homotetramer interface [polypeptide binding]; other site
767029000667	putative allosteric switch controlling residues; other site
767029000668	putative metal binding site [ion binding]; other site
767029000669	putative homodimer-homodimer interface [polypeptide binding]; other site
767029000670	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
767029000671	metal-binding site [ion binding]
767029000672	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
767029000673	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
767029000674	metal-binding site [ion binding]
767029000675	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
767029000676	Soluble P-type ATPase [General function prediction only]; Region: COG4087
767029000677	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029000678	Major Facilitator Superfamily; Region: MFS_1; pfam07690
767029000679	putative substrate translocation pore; other site
767029000680	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029000681	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029000682	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029000683	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
767029000684	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
767029000685	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
767029000686	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
767029000687	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029000688	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029000689	active site
767029000690	phosphorylation site [posttranslational modification]
767029000691	intermolecular recognition site; other site
767029000692	dimerization interface [polypeptide binding]; other site
767029000693	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029000694	DNA binding residues [nucleotide binding]
767029000695	dimerization interface [polypeptide binding]; other site
767029000696	Histidine kinase; Region: HisKA_3; pfam07730
767029000697	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029000698	ATP binding site [chemical binding]; other site
767029000699	Mg2+ binding site [ion binding]; other site
767029000700	G-X-G motif; other site
767029000701	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
767029000702	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029000703	Walker A/P-loop; other site
767029000704	ATP binding site [chemical binding]; other site
767029000705	Q-loop/lid; other site
767029000706	ABC transporter signature motif; other site
767029000707	Walker B; other site
767029000708	D-loop; other site
767029000709	H-loop/switch region; other site
767029000710	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
767029000711	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
767029000712	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
767029000713	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
767029000714	Penicillinase repressor; Region: Pencillinase_R; cl17580
767029000715	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
767029000716	iron-sulfur cluster [ion binding]; other site
767029000717	[2Fe-2S] cluster binding site [ion binding]; other site
767029000718	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029000719	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029000720	GAD-like domain; Region: GAD-like; pfam08887
767029000721	Domain of unknown function (DUF1851); Region: DUF1851; pfam08906
767029000722	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
767029000723	FAD binding domain; Region: FAD_binding_4; pfam01565
767029000724	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
767029000725	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
767029000726	putative acyl-acceptor binding pocket; other site
767029000727	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
767029000728	classical (c) SDRs; Region: SDR_c; cd05233
767029000729	NAD(P) binding site [chemical binding]; other site
767029000730	active site
767029000731	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
767029000732	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
767029000733	putative dimer interface [polypeptide binding]; other site
767029000734	catalytic triad [active]
767029000735	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
767029000736	active site
767029000737	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
767029000738	propionate/acetate kinase; Provisional; Region: PRK12379
767029000739	phosphate acetyltransferase; Reviewed; Region: PRK05632
767029000740	DRTGG domain; Region: DRTGG; pfam07085
767029000741	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
767029000742	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
767029000743	Aspartase; Region: Aspartase; cd01357
767029000744	active sites [active]
767029000745	tetramer interface [polypeptide binding]; other site
767029000746	endonuclease IV; Provisional; Region: PRK01060
767029000747	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
767029000748	DNA interaction; other site
767029000749	Metal-binding active site; metal-binding site
767029000750	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
767029000751	putative DNA binding site [nucleotide binding]; other site
767029000752	putative Zn2+ binding site [ion binding]; other site
767029000753	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
767029000754	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
767029000755	nucleotide binding site [chemical binding]; other site
767029000756	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
767029000757	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
767029000758	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029000759	dimer interface [polypeptide binding]; other site
767029000760	conserved gate region; other site
767029000761	putative PBP binding loops; other site
767029000762	ABC-ATPase subunit interface; other site
767029000763	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
767029000764	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029000765	dimer interface [polypeptide binding]; other site
767029000766	conserved gate region; other site
767029000767	putative PBP binding loops; other site
767029000768	ABC-ATPase subunit interface; other site
767029000769	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
767029000770	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
767029000771	nucleotide binding site [chemical binding]; other site
767029000772	Uncharacterized conserved protein [Function unknown]; Region: COG5476
767029000773	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
767029000774	MlrC C-terminus; Region: MlrC_C; pfam07171
767029000775	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
767029000776	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
767029000777	TQXA domain; Region: TQXA_dom; TIGR03934
767029000778	TQXA domain; Region: TQXA_dom; TIGR03934
767029000779	TQXA domain; Region: TQXA_dom; TIGR03934
767029000780	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
767029000781	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
767029000782	Ca binding site [ion binding]; other site
767029000783	active site
767029000784	catalytic site [active]
767029000785	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
767029000786	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
767029000787	dimerization interface [polypeptide binding]; other site
767029000788	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
767029000789	dimer interface [polypeptide binding]; other site
767029000790	phosphorylation site [posttranslational modification]
767029000791	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029000792	ATP binding site [chemical binding]; other site
767029000793	Mg2+ binding site [ion binding]; other site
767029000794	G-X-G motif; other site
767029000795	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
767029000796	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029000797	active site
767029000798	phosphorylation site [posttranslational modification]
767029000799	intermolecular recognition site; other site
767029000800	dimerization interface [polypeptide binding]; other site
767029000801	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
767029000802	DNA binding site [nucleotide binding]
767029000803	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
767029000804	Low molecular weight phosphatase family; Region: LMWPc; cd00115
767029000805	active site
767029000806	ornithine carbamoyltransferase; Validated; Region: PRK02102
767029000807	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
767029000808	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
767029000809	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
767029000810	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
767029000811	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
767029000812	TPP-binding site [chemical binding]; other site
767029000813	heterodimer interface [polypeptide binding]; other site
767029000814	tetramer interface [polypeptide binding]; other site
767029000815	phosphorylation loop region [posttranslational modification]
767029000816	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
767029000817	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
767029000818	alpha subunit interface [polypeptide binding]; other site
767029000819	TPP binding site [chemical binding]; other site
767029000820	heterodimer interface [polypeptide binding]; other site
767029000821	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
767029000822	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
767029000823	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
767029000824	E3 interaction surface; other site
767029000825	lipoyl attachment site [posttranslational modification]; other site
767029000826	e3 binding domain; Region: E3_binding; pfam02817
767029000827	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
767029000828	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
767029000829	active site
767029000830	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
767029000831	alanine racemase; Reviewed; Region: alr; PRK00053
767029000832	dimer interface [polypeptide binding]; other site
767029000833	substrate binding site [chemical binding]; other site
767029000834	catalytic residues [active]
767029000835	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
767029000836	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
767029000837	prephenate dehydratase; Provisional; Region: PRK11898
767029000838	Prephenate dehydratase; Region: PDT; pfam00800
767029000839	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
767029000840	putative L-Phe binding site [chemical binding]; other site
767029000841	seryl-tRNA synthetase; Provisional; Region: PRK05431
767029000842	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
767029000843	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
767029000844	dimer interface [polypeptide binding]; other site
767029000845	active site
767029000846	motif 1; other site
767029000847	motif 2; other site
767029000848	motif 3; other site
767029000849	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
767029000850	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
767029000851	active site
767029000852	motif I; other site
767029000853	motif II; other site
767029000854	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
767029000855	Transcription factor WhiB; Region: Whib; pfam02467
767029000856	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
767029000857	Helix-turn-helix domain; Region: HTH_38; pfam13936
767029000858	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
767029000859	Transcription factor WhiB; Region: Whib; pfam02467
767029000860	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
767029000861	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
767029000862	homotrimer interaction site [polypeptide binding]; other site
767029000863	putative active site [active]
767029000864	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
767029000865	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
767029000866	minor groove reading motif; other site
767029000867	helix-hairpin-helix signature motif; other site
767029000868	substrate binding pocket [chemical binding]; other site
767029000869	active site
767029000870	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
767029000871	putative active site [active]
767029000872	putative CoA binding site [chemical binding]; other site
767029000873	nudix motif; other site
767029000874	metal binding site [ion binding]; metal-binding site
767029000875	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
767029000876	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029000877	Walker A/P-loop; other site
767029000878	ATP binding site [chemical binding]; other site
767029000879	Q-loop/lid; other site
767029000880	ABC transporter signature motif; other site
767029000881	Walker B; other site
767029000882	D-loop; other site
767029000883	H-loop/switch region; other site
767029000884	Protein of unknown function (DUF1464); Region: DUF1464; cl17839
767029000885	Histidine kinase; Region: HisKA_3; pfam07730
767029000886	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
767029000887	ATP binding site [chemical binding]; other site
767029000888	Mg2+ binding site [ion binding]; other site
767029000889	G-X-G motif; other site
767029000890	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029000891	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029000892	active site
767029000893	phosphorylation site [posttranslational modification]
767029000894	intermolecular recognition site; other site
767029000895	dimerization interface [polypeptide binding]; other site
767029000896	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029000897	DNA binding residues [nucleotide binding]
767029000898	dimerization interface [polypeptide binding]; other site
767029000899	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
767029000900	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
767029000901	FtsX-like permease family; Region: FtsX; pfam02687
767029000902	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
767029000903	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
767029000904	Walker A/P-loop; other site
767029000905	ATP binding site [chemical binding]; other site
767029000906	Q-loop/lid; other site
767029000907	ABC transporter signature motif; other site
767029000908	Walker B; other site
767029000909	D-loop; other site
767029000910	H-loop/switch region; other site
767029000911	PGAP1-like protein; Region: PGAP1; pfam07819
767029000912	Tetratricopeptide repeat; Region: TPR_12; pfam13424
767029000913	Tetratricopeptide repeat; Region: TPR_12; pfam13424
767029000914	Tetratricopeptide repeat; Region: TPR_12; pfam13424
767029000915	Tetratricopeptide repeat; Region: TPR_12; pfam13424
767029000916	Tetratricopeptide repeat; Region: TPR_12; pfam13424
767029000917	Tetratricopeptide repeat; Region: TPR_12; pfam13424
767029000918	Tetratricopeptide repeat; Region: TPR_12; pfam13424
767029000919	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
767029000920	binding surface
767029000921	TPR motif; other site
767029000922	Tetratricopeptide repeat; Region: TPR_12; pfam13424
767029000923	Tetratricopeptide repeat; Region: TPR_12; pfam13424
767029000924	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
767029000925	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
767029000926	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
767029000927	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
767029000928	helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819
767029000929	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
767029000930	Walker A motif; other site
767029000931	ATP binding site [chemical binding]; other site
767029000932	Walker B motif; other site
767029000933	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
767029000934	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
767029000935	Histidine kinase; Region: HisKA_3; pfam07730
767029000936	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029000937	ATP binding site [chemical binding]; other site
767029000938	Mg2+ binding site [ion binding]; other site
767029000939	G-X-G motif; other site
767029000940	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029000941	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029000942	active site
767029000943	phosphorylation site [posttranslational modification]
767029000944	intermolecular recognition site; other site
767029000945	dimerization interface [polypeptide binding]; other site
767029000946	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029000947	DNA binding residues [nucleotide binding]
767029000948	dimerization interface [polypeptide binding]; other site
767029000949	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
767029000950	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
767029000951	Walker A/P-loop; other site
767029000952	ATP binding site [chemical binding]; other site
767029000953	Q-loop/lid; other site
767029000954	ABC transporter signature motif; other site
767029000955	Walker B; other site
767029000956	D-loop; other site
767029000957	H-loop/switch region; other site
767029000958	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200
767029000959	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
767029000960	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200
767029000961	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
767029000962	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
767029000963	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
767029000964	ATP binding site [chemical binding]; other site
767029000965	putative Mg++ binding site [ion binding]; other site
767029000966	helicase superfamily c-terminal domain; Region: HELICc; smart00490
767029000967	nucleotide binding region [chemical binding]; other site
767029000968	ATP-binding site [chemical binding]; other site
767029000969	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
767029000970	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
767029000971	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
767029000972	putative active site [active]
767029000973	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
767029000974	putative active site [active]
767029000975	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
767029000976	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
767029000977	active site
767029000978	SAM binding site [chemical binding]; other site
767029000979	putative homodimer interface [polypeptide binding]; other site
767029000980	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
767029000981	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
767029000982	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
767029000983	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
767029000984	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
767029000985	active site
767029000986	SAM binding site [chemical binding]; other site
767029000987	homodimer interface [polypeptide binding]; other site
767029000988	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
767029000989	active site
767029000990	SAM binding site [chemical binding]; other site
767029000991	homodimer interface [polypeptide binding]; other site
767029000992	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
767029000993	homodimer interface [polypeptide binding]; other site
767029000994	active site
767029000995	SAM binding site [chemical binding]; other site
767029000996	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
767029000997	Precorrin-8X methylmutase; Region: CbiC; pfam02570
767029000998	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
767029000999	Cna protein B-type domain; Region: Cna_B_2; pfam13715
767029001000	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
767029001001	S-adenosylmethionine binding site [chemical binding]; other site
767029001002	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
767029001003	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
767029001004	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029001005	H-loop/switch region; other site
767029001006	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
767029001007	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
767029001008	Divergent AAA domain; Region: AAA_4; pfam04326
767029001009	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
767029001010	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
767029001011	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
767029001012	active site
767029001013	substrate binding site [chemical binding]; other site
767029001014	coenzyme B12 binding site [chemical binding]; other site
767029001015	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
767029001016	B12 binding site [chemical binding]; other site
767029001017	cobalt ligand [ion binding]; other site
767029001018	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
767029001019	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
767029001020	heterodimer interface [polypeptide binding]; other site
767029001021	substrate interaction site [chemical binding]; other site
767029001022	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424
767029001023	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
767029001024	catalytic core [active]
767029001025	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
767029001026	active site
767029001027	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
767029001028	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
767029001029	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
767029001030	DNA binding residues [nucleotide binding]
767029001031	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
767029001032	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
767029001033	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
767029001034	Walker A motif; other site
767029001035	ATP binding site [chemical binding]; other site
767029001036	Walker B motif; other site
767029001037	arginine finger; other site
767029001038	Peptidase family M41; Region: Peptidase_M41; pfam01434
767029001039	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
767029001040	homodecamer interface [polypeptide binding]; other site
767029001041	GTP cyclohydrolase I; Provisional; Region: PLN03044
767029001042	active site
767029001043	putative catalytic site residues [active]
767029001044	zinc binding site [ion binding]; other site
767029001045	GTP-CH-I/GFRP interaction surface; other site
767029001046	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
767029001047	dihydropteroate synthase; Region: DHPS; TIGR01496
767029001048	substrate binding pocket [chemical binding]; other site
767029001049	dimer interface [polypeptide binding]; other site
767029001050	inhibitor binding site; inhibition site
767029001051	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
767029001052	catalytic center binding site [active]
767029001053	ATP binding site [chemical binding]; other site
767029001054	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
767029001055	Lsr2; Region: Lsr2; pfam11774
767029001056	Clp protease ATP binding subunit; Region: clpC; CHL00095
767029001057	Clp amino terminal domain; Region: Clp_N; pfam02861
767029001058	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
767029001059	Walker A motif; other site
767029001060	ATP binding site [chemical binding]; other site
767029001061	Walker B motif; other site
767029001062	arginine finger; other site
767029001063	UvrB/uvrC motif; Region: UVR; pfam02151
767029001064	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
767029001065	Walker A motif; other site
767029001066	ATP binding site [chemical binding]; other site
767029001067	Walker B motif; other site
767029001068	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
767029001069	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
767029001070	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
767029001071	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
767029001072	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
767029001073	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
767029001074	Helix-turn-helix domain; Region: HTH_38; pfam13936
767029001075	Integrase core domain; Region: rve; pfam00665
767029001076	DNA repair protein RadA; Provisional; Region: PRK11823
767029001077	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
767029001078	Walker A motif; other site
767029001079	ATP binding site [chemical binding]; other site
767029001080	Walker B motif; other site
767029001081	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
767029001082	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
767029001083	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
767029001084	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
767029001085	AP (apurinic/apyrimidinic) site pocket; other site
767029001086	DNA interaction; other site
767029001087	Metal-binding active site; metal-binding site
767029001088	Proline dehydrogenase; Region: Pro_dh; cl03282
767029001089	CAAX protease self-immunity; Region: Abi; pfam02517
767029001090	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
767029001091	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
767029001092	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
767029001093	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
767029001094	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
767029001095	active site
767029001096	homodimer interface [polypeptide binding]; other site
767029001097	SAM binding site [chemical binding]; other site
767029001098	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
767029001099	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
767029001100	active site
767029001101	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
767029001102	catalytic core [active]
767029001103	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
767029001104	Sporulation and spore germination; Region: Germane; pfam10646
767029001105	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
767029001106	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
767029001107	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
767029001108	NAD(P) binding site [chemical binding]; other site
767029001109	active site
767029001110	mycothione reductase; Reviewed; Region: PRK07846
767029001111	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
767029001112	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
767029001113	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
767029001114	malate dehydrogenase; Provisional; Region: PRK13529
767029001115	Malic enzyme, N-terminal domain; Region: malic; pfam00390
767029001116	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
767029001117	NAD(P) binding site [chemical binding]; other site
767029001118	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
767029001119	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
767029001120	Walker A/P-loop; other site
767029001121	ATP binding site [chemical binding]; other site
767029001122	Q-loop/lid; other site
767029001123	ABC transporter signature motif; other site
767029001124	Walker B; other site
767029001125	D-loop; other site
767029001126	H-loop/switch region; other site
767029001127	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
767029001128	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029001129	dimer interface [polypeptide binding]; other site
767029001130	conserved gate region; other site
767029001131	putative PBP binding loops; other site
767029001132	ABC-ATPase subunit interface; other site
767029001133	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
767029001134	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
767029001135	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029001136	dimer interface [polypeptide binding]; other site
767029001137	conserved gate region; other site
767029001138	ABC-ATPase subunit interface; other site
767029001139	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
767029001140	PBP superfamily domain; Region: PBP_like_2; cl17296
767029001141	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
767029001142	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
767029001143	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
767029001144	Walker A motif; other site
767029001145	ATP binding site [chemical binding]; other site
767029001146	Walker B motif; other site
767029001147	arginine finger; other site
767029001148	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
767029001149	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
767029001150	active site
767029001151	Ap6A binding site [chemical binding]; other site
767029001152	nudix motif; other site
767029001153	metal binding site [ion binding]; metal-binding site
767029001154	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
767029001155	catalytic core [active]
767029001156	polyphosphate kinase; Provisional; Region: PRK05443
767029001157	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
767029001158	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
767029001159	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
767029001160	putative domain interface [polypeptide binding]; other site
767029001161	putative active site [active]
767029001162	catalytic site [active]
767029001163	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
767029001164	putative domain interface [polypeptide binding]; other site
767029001165	putative active site [active]
767029001166	catalytic site [active]
767029001167	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
767029001168	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
767029001169	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
767029001170	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
767029001171	DNA binding site [nucleotide binding]
767029001172	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
767029001173	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
767029001174	putative active site [active]
767029001175	dimerization interface [polypeptide binding]; other site
767029001176	putative tRNAtyr binding site [nucleotide binding]; other site
767029001177	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
767029001178	heme-binding site [chemical binding]; other site
767029001179	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
767029001180	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
767029001181	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
767029001182	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
767029001183	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
767029001184	dimer interface [polypeptide binding]; other site
767029001185	substrate binding site [chemical binding]; other site
767029001186	ATP binding site [chemical binding]; other site
767029001187	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
767029001188	dimer interface [polypeptide binding]; other site
767029001189	catalytic triad [active]
767029001190	peroxidatic and resolving cysteines [active]
767029001191	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
767029001192	Transcriptional regulator [Transcription]; Region: LysR; COG0583
767029001193	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
767029001194	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
767029001195	dimerization interface [polypeptide binding]; other site
767029001196	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
767029001197	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
767029001198	ligand binding site [chemical binding]; other site
767029001199	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
767029001200	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
767029001201	G1 box; other site
767029001202	putative GEF interaction site [polypeptide binding]; other site
767029001203	GTP/Mg2+ binding site [chemical binding]; other site
767029001204	Switch I region; other site
767029001205	G2 box; other site
767029001206	G3 box; other site
767029001207	Switch II region; other site
767029001208	G4 box; other site
767029001209	G5 box; other site
767029001210	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
767029001211	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
767029001212	dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377
767029001213	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
767029001214	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
767029001215	dimerization domain swap beta strand [polypeptide binding]; other site
767029001216	regulatory protein interface [polypeptide binding]; other site
767029001217	active site
767029001218	regulatory phosphorylation site [posttranslational modification]; other site
767029001219	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
767029001220	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
767029001221	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
767029001222	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
767029001223	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
767029001224	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
767029001225	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
767029001226	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
767029001227	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
767029001228	GDP-binding site [chemical binding]; other site
767029001229	ACT binding site; other site
767029001230	IMP binding site; other site
767029001231	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
767029001232	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
767029001233	Protein of unknown function, DUF488; Region: DUF488; cl01246
767029001234	EXLDI protein; Region: EXLDI; TIGR04342
767029001235	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
767029001236	FOG: WD40 repeat [General function prediction only]; Region: COG2319
767029001237	structural tetrad; other site
767029001238	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
767029001239	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
767029001240	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
767029001241	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
767029001242	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
767029001243	adenylosuccinate lyase; Reviewed; Region: PRK08540
767029001244	tetramer interface [polypeptide binding]; other site
767029001245	H+ Antiporter protein; Region: 2A0121; TIGR00900
767029001246	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029001247	putative substrate translocation pore; other site
767029001248	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
767029001249	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
767029001250	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029001251	Walker A/P-loop; other site
767029001252	ATP binding site [chemical binding]; other site
767029001253	Q-loop/lid; other site
767029001254	ABC transporter signature motif; other site
767029001255	Walker B; other site
767029001256	D-loop; other site
767029001257	H-loop/switch region; other site
767029001258	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
767029001259	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029001260	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029001261	active site
767029001262	phosphorylation site [posttranslational modification]
767029001263	intermolecular recognition site; other site
767029001264	dimerization interface [polypeptide binding]; other site
767029001265	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029001266	DNA binding residues [nucleotide binding]
767029001267	dimerization interface [polypeptide binding]; other site
767029001268	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
767029001269	Histidine kinase; Region: HisKA_3; pfam07730
767029001270	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029001271	ATP binding site [chemical binding]; other site
767029001272	Mg2+ binding site [ion binding]; other site
767029001273	G-X-G motif; other site
767029001274	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
767029001275	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
767029001276	Walker A/P-loop; other site
767029001277	ATP binding site [chemical binding]; other site
767029001278	Q-loop/lid; other site
767029001279	ABC transporter signature motif; other site
767029001280	Walker B; other site
767029001281	D-loop; other site
767029001282	H-loop/switch region; other site
767029001283	FtsX-like permease family; Region: FtsX; pfam02687
767029001284	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
767029001285	ATP binding site [chemical binding]; other site
767029001286	active site
767029001287	substrate binding site [chemical binding]; other site
767029001288	TIGR02452 family protein; Region: TIGR02452
767029001289	Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021
767029001290	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
767029001291	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
767029001292	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
767029001293	putative active site [active]
767029001294	catalytic triad [active]
767029001295	Bax inhibitor 1 like; Region: BaxI_1; cl17691
767029001296	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
767029001297	nudix motif; other site
767029001298	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
767029001299	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
767029001300	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
767029001301	methionine sulfoxide reductase A; Provisional; Region: PRK00058
767029001302	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
767029001303	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
767029001304	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
767029001305	Beta-lactamase; Region: Beta-lactamase; pfam00144
767029001306	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
767029001307	Histidine kinase; Region: HisKA_3; pfam07730
767029001308	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
767029001309	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029001310	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029001311	active site
767029001312	phosphorylation site [posttranslational modification]
767029001313	intermolecular recognition site; other site
767029001314	dimerization interface [polypeptide binding]; other site
767029001315	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029001316	DNA binding residues [nucleotide binding]
767029001317	dimerization interface [polypeptide binding]; other site
767029001318	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
767029001319	ligand binding site [chemical binding]; other site
767029001320	active site
767029001321	UGI interface [polypeptide binding]; other site
767029001322	catalytic site [active]
767029001323	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
767029001324	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
767029001325	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
767029001326	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
767029001327	catalytic residues [active]
767029001328	Rhomboid family; Region: Rhomboid; pfam01694
767029001329	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
767029001330	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
767029001331	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
767029001332	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
767029001333	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
767029001334	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
767029001335	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
767029001336	substrate binding site [chemical binding]; other site
767029001337	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
767029001338	NADH(P)-binding; Region: NAD_binding_10; pfam13460
767029001339	NAD(P) binding site [chemical binding]; other site
767029001340	active site
767029001341	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029001342	Major Facilitator Superfamily; Region: MFS_1; pfam07690
767029001343	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029001344	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029001345	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
767029001346	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
767029001347	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
767029001348	catalytic residues [active]
767029001349	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
767029001350	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
767029001351	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
767029001352	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
767029001353	catalytic residues [active]
767029001354	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
767029001355	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029001356	active site
767029001357	phosphorylation site [posttranslational modification]
767029001358	intermolecular recognition site; other site
767029001359	dimerization interface [polypeptide binding]; other site
767029001360	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
767029001361	DNA binding site [nucleotide binding]
767029001362	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
767029001363	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
767029001364	dimer interface [polypeptide binding]; other site
767029001365	phosphorylation site [posttranslational modification]
767029001366	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029001367	ATP binding site [chemical binding]; other site
767029001368	Mg2+ binding site [ion binding]; other site
767029001369	G-X-G motif; other site
767029001370	Part of AAA domain; Region: AAA_19; pfam13245
767029001371	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
767029001372	Family description; Region: UvrD_C_2; pfam13538
767029001373	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
767029001374	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
767029001375	pyridoxal 5'-phosphate binding site [chemical binding]; other site
767029001376	catalytic residue [active]
767029001377	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
767029001378	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
767029001379	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
767029001380	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029001381	Major Facilitator Superfamily; Region: MFS_1; pfam07690
767029001382	putative substrate translocation pore; other site
767029001383	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029001384	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
767029001385	Predicted methyltransferases [General function prediction only]; Region: COG0313
767029001386	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
767029001387	putative SAM binding site [chemical binding]; other site
767029001388	putative homodimer interface [polypeptide binding]; other site
767029001389	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
767029001390	active site
767029001391	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
767029001392	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
767029001393	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
767029001394	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
767029001395	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
767029001396	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
767029001397	MarR family; Region: MarR_2; pfam12802
767029001398	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
767029001399	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
767029001400	Walker A/P-loop; other site
767029001401	ATP binding site [chemical binding]; other site
767029001402	Q-loop/lid; other site
767029001403	ABC transporter signature motif; other site
767029001404	Walker B; other site
767029001405	D-loop; other site
767029001406	H-loop/switch region; other site
767029001407	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
767029001408	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029001409	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029001410	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
767029001411	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
767029001412	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
767029001413	Substrate binding site; other site
767029001414	Mg++ binding site; other site
767029001415	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
767029001416	active site
767029001417	substrate binding site [chemical binding]; other site
767029001418	CoA binding site [chemical binding]; other site
767029001419	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
767029001420	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
767029001421	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
767029001422	active site
767029001423	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
767029001424	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
767029001425	NAD binding site [chemical binding]; other site
767029001426	dimer interface [polypeptide binding]; other site
767029001427	substrate binding site [chemical binding]; other site
767029001428	tetramer (dimer of dimers) interface [polypeptide binding]; other site
767029001429	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
767029001430	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
767029001431	non-specific DNA interactions [nucleotide binding]; other site
767029001432	DNA binding site [nucleotide binding]
767029001433	sequence specific DNA binding site [nucleotide binding]; other site
767029001434	putative cAMP binding site [chemical binding]; other site
767029001435	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
767029001436	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
767029001437	Walker A/P-loop; other site
767029001438	ATP binding site [chemical binding]; other site
767029001439	Q-loop/lid; other site
767029001440	ABC transporter signature motif; other site
767029001441	Walker B; other site
767029001442	D-loop; other site
767029001443	H-loop/switch region; other site
767029001444	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
767029001445	FtsX-like permease family; Region: FtsX; pfam02687
767029001446	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
767029001447	DNA-binding site [nucleotide binding]; DNA binding site
767029001448	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
767029001449	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
767029001450	Walker A/P-loop; other site
767029001451	ATP binding site [chemical binding]; other site
767029001452	Q-loop/lid; other site
767029001453	ABC transporter signature motif; other site
767029001454	Walker B; other site
767029001455	D-loop; other site
767029001456	H-loop/switch region; other site
767029001457	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
767029001458	active site
767029001459	DNA binding site [nucleotide binding]
767029001460	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
767029001461	catalytic core [active]
767029001462	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
767029001463	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
767029001464	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
767029001465	dimerization interface [polypeptide binding]; other site
767029001466	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
767029001467	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
767029001468	SnoaL-like domain; Region: SnoaL_4; pfam13577
767029001469	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
767029001470	FAD binding pocket [chemical binding]; other site
767029001471	conserved FAD binding motif [chemical binding]; other site
767029001472	phosphate binding motif [ion binding]; other site
767029001473	beta-alpha-beta structure motif; other site
767029001474	NAD binding pocket [chemical binding]; other site
767029001475	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
767029001476	5S rRNA interface [nucleotide binding]; other site
767029001477	CTC domain interface [polypeptide binding]; other site
767029001478	L16 interface [polypeptide binding]; other site
767029001479	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
767029001480	putative active site [active]
767029001481	catalytic residue [active]
767029001482	nickel-responsive transcriptional regulator NikR; Region: nikR; TIGR02793
767029001483	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
767029001484	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
767029001485	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
767029001486	ATP binding site [chemical binding]; other site
767029001487	putative Mg++ binding site [ion binding]; other site
767029001488	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
767029001489	nucleotide binding region [chemical binding]; other site
767029001490	ATP-binding site [chemical binding]; other site
767029001491	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
767029001492	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333
767029001493	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
767029001494	homodimer interface [polypeptide binding]; other site
767029001495	metal binding site [ion binding]; metal-binding site
767029001496	TROVE domain; Region: TROVE; pfam05731
767029001497	Mitochondrial ribosomal protein subunit L20; Region: MRP-L20; pfam12824
767029001498	enolase; Provisional; Region: eno; PRK00077
767029001499	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
767029001500	dimer interface [polypeptide binding]; other site
767029001501	metal binding site [ion binding]; metal-binding site
767029001502	substrate binding pocket [chemical binding]; other site
767029001503	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
767029001504	Septum formation initiator; Region: DivIC; pfam04977
767029001505	Protein of unknown function (DUF501); Region: DUF501; cl00652
767029001506	exopolyphosphatase; Region: exo_poly_only; TIGR03706
767029001507	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
767029001508	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
767029001509	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
767029001510	substrate binding site [chemical binding]; other site
767029001511	ATP binding site [chemical binding]; other site
767029001512	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
767029001513	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
767029001514	dimerization interface [polypeptide binding]; other site
767029001515	ATP binding site [chemical binding]; other site
767029001516	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
767029001517	dimerization interface [polypeptide binding]; other site
767029001518	ATP binding site [chemical binding]; other site
767029001519	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
767029001520	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
767029001521	Peptidase family M28; Region: Peptidase_M28; pfam04389
767029001522	metal binding site [ion binding]; metal-binding site
767029001523	2-enoyl thioester reductase-like; Region: ETR_like; cd05282
767029001524	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
767029001525	NADP binding site [chemical binding]; other site
767029001526	dimer interface [polypeptide binding]; other site
767029001527	Putative FMN-binding domain; Region: FMN_bind_2; cl17803
767029001528	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
767029001529	intersubunit interface [polypeptide binding]; other site
767029001530	active site
767029001531	zinc binding site [ion binding]; other site
767029001532	Na+ binding site [ion binding]; other site
767029001533	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
767029001534	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
767029001535	motif II; other site
767029001536	Class I aldolases; Region: Aldolase_Class_I; cl17187
767029001537	catalytic residue [active]
767029001538	Class I aldolases; Region: Aldolase_Class_I; cl17187
767029001539	catalytic residue [active]
767029001540	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
767029001541	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
767029001542	nucleotide binding site [chemical binding]; other site
767029001543	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
767029001544	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
767029001545	DNA-binding site [nucleotide binding]; DNA binding site
767029001546	UTRA domain; Region: UTRA; pfam07702
767029001547	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
767029001548	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
767029001549	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
767029001550	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
767029001551	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029001552	active site
767029001553	phosphorylation site [posttranslational modification]
767029001554	intermolecular recognition site; other site
767029001555	dimerization interface [polypeptide binding]; other site
767029001556	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
767029001557	DNA binding site [nucleotide binding]
767029001558	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
767029001559	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
767029001560	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029001561	ATP binding site [chemical binding]; other site
767029001562	Mg2+ binding site [ion binding]; other site
767029001563	G-X-G motif; other site
767029001564	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
767029001565	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029001566	Walker A/P-loop; other site
767029001567	ATP binding site [chemical binding]; other site
767029001568	Q-loop/lid; other site
767029001569	ABC transporter signature motif; other site
767029001570	Walker B; other site
767029001571	D-loop; other site
767029001572	H-loop/switch region; other site
767029001573	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029001574	dimer interface [polypeptide binding]; other site
767029001575	conserved gate region; other site
767029001576	putative PBP binding loops; other site
767029001577	ABC-ATPase subunit interface; other site
767029001578	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
767029001579	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
767029001580	substrate binding pocket [chemical binding]; other site
767029001581	membrane-bound complex binding site; other site
767029001582	hinge residues; other site
767029001583	Helix-turn-helix domain; Region: HTH_28; pfam13518
767029001584	Winged helix-turn helix; Region: HTH_29; pfam13551
767029001585	Homeodomain-like domain; Region: HTH_32; pfam13565
767029001586	DDE superfamily endonuclease; Region: DDE_3; pfam13358
767029001587	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
767029001588	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
767029001589	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
767029001590	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
767029001591	CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834
767029001592	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
767029001593	MarR family; Region: MarR_2; pfam12802
767029001594	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
767029001595	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
767029001596	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
767029001597	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
767029001598	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
767029001599	motif II; other site
767029001600	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
767029001601	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
767029001602	Helix-turn-helix domain; Region: HTH_28; pfam13518
767029001603	Winged helix-turn helix; Region: HTH_29; pfam13551
767029001604	Homeodomain-like domain; Region: HTH_32; pfam13565
767029001605	DDE superfamily endonuclease; Region: DDE_3; pfam13358
767029001606	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
767029001607	TIGR03086 family protein; Region: TIGR03086
767029001608	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
767029001609	Helix-turn-helix domain; Region: HTH_18; pfam12833
767029001610	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
767029001611	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
767029001612	active site
767029001613	intersubunit interactions; other site
767029001614	catalytic residue [active]
767029001615	Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310
767029001616	HlyD family secretion protein; Region: HlyD_3; pfam13437
767029001617	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
767029001618	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
767029001619	DXD motif; other site
767029001620	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
767029001621	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
767029001622	putative DNA binding site [nucleotide binding]; other site
767029001623	putative Zn2+ binding site [ion binding]; other site
767029001624	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
767029001625	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
767029001626	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
767029001627	E3 interaction surface; other site
767029001628	lipoyl attachment site [posttranslational modification]; other site
767029001629	e3 binding domain; Region: E3_binding; pfam02817
767029001630	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
767029001631	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
767029001632	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
767029001633	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
767029001634	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
767029001635	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
767029001636	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
767029001637	tetramer interface [polypeptide binding]; other site
767029001638	TPP-binding site [chemical binding]; other site
767029001639	heterodimer interface [polypeptide binding]; other site
767029001640	phosphorylation loop region [posttranslational modification]
767029001641	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
767029001642	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
767029001643	PYR/PP interface [polypeptide binding]; other site
767029001644	dimer interface [polypeptide binding]; other site
767029001645	TPP binding site [chemical binding]; other site
767029001646	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
767029001647	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
767029001648	active site
767029001649	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
767029001650	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
767029001651	NAD(P) binding site [chemical binding]; other site
767029001652	active site
767029001653	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
767029001654	Alcohol dehydrogenase GroES-like domain; Region: ADH_N; pfam08240
767029001655	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
767029001656	NAD(P) binding site [chemical binding]; other site
767029001657	ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885
767029001658	dihydroxyacetone kinase; Provisional; Region: PRK14479
767029001659	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
767029001660	DAK2 domain; Region: Dak2; pfam02734
767029001661	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
767029001662	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
767029001663	NAD(P) binding site [chemical binding]; other site
767029001664	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
767029001665	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
767029001666	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
767029001667	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
767029001668	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
767029001669	inhibitor-cofactor binding pocket; inhibition site
767029001670	pyridoxal 5'-phosphate binding site [chemical binding]; other site
767029001671	catalytic residue [active]
767029001672	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
767029001673	active site
767029001674	DNA binding site [nucleotide binding]
767029001675	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
767029001676	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
767029001677	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
767029001678	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
767029001679	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
767029001680	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
767029001681	nucleophilic elbow; other site
767029001682	catalytic triad; other site
767029001683	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
767029001684	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
767029001685	oxaloacetate decarboxylase; Provisional; Region: PRK12330
767029001686	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
767029001687	active site
767029001688	catalytic residues [active]
767029001689	metal binding site [ion binding]; metal-binding site
767029001690	homodimer binding site [polypeptide binding]; other site
767029001691	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
767029001692	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
767029001693	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
767029001694	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
767029001695	carboxyltransferase (CT) interaction site; other site
767029001696	biotinylation site [posttranslational modification]; other site
767029001697	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
767029001698	Walker A/P-loop; other site
767029001699	ATP binding site [chemical binding]; other site
767029001700	Q-loop/lid; other site
767029001701	ABC transporter signature motif; other site
767029001702	Walker B; other site
767029001703	D-loop; other site
767029001704	H-loop/switch region; other site
767029001705	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
767029001706	Ligand Binding Site [chemical binding]; other site
767029001707	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029001708	Major Facilitator Superfamily; Region: MFS_1; pfam07690
767029001709	putative substrate translocation pore; other site
767029001710	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
767029001711	putative hydrophobic ligand binding site [chemical binding]; other site
767029001712	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
767029001713	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
767029001714	putative ion selectivity filter; other site
767029001715	putative pore gating glutamate residue; other site
767029001716	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
767029001717	catalytic core [active]
767029001718	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
767029001719	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
767029001720	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
767029001721	NodB motif; other site
767029001722	active site
767029001723	catalytic site [active]
767029001724	Zn binding site [ion binding]; other site
767029001725	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
767029001726	PhoU domain; Region: PhoU; pfam01895
767029001727	PhoU domain; Region: PhoU; pfam01895
767029001728	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
767029001729	phosphorylation site [posttranslational modification]
767029001730	dimer interface [polypeptide binding]; other site
767029001731	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029001732	ATP binding site [chemical binding]; other site
767029001733	Mg2+ binding site [ion binding]; other site
767029001734	G-X-G motif; other site
767029001735	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
767029001736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029001737	active site
767029001738	phosphorylation site [posttranslational modification]
767029001739	intermolecular recognition site; other site
767029001740	dimerization interface [polypeptide binding]; other site
767029001741	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
767029001742	DNA binding site [nucleotide binding]
767029001743	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
767029001744	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
767029001745	homotrimer interaction site [polypeptide binding]; other site
767029001746	zinc binding site [ion binding]; other site
767029001747	CDP-binding sites; other site
767029001748	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
767029001749	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
767029001750	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
767029001751	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
767029001752	Helix-turn-helix domain; Region: HTH_38; pfam13936
767029001753	Integrase core domain; Region: rve; pfam00665
767029001754	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029001755	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029001756	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029001757	Major Facilitator Superfamily; Region: MFS_1; pfam07690
767029001758	putative substrate translocation pore; other site
767029001759	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
767029001760	H+ Antiporter protein; Region: 2A0121; TIGR00900
767029001761	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029001762	putative substrate translocation pore; other site
767029001763	serine hydroxymethyltransferase; Provisional; Region: PRK13580
767029001764	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
767029001765	dimer interface [polypeptide binding]; other site
767029001766	active site
767029001767	glycine-pyridoxal phosphate binding site [chemical binding]; other site
767029001768	folate binding site [chemical binding]; other site
767029001769	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
767029001770	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
767029001771	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029001772	Walker A/P-loop; other site
767029001773	ATP binding site [chemical binding]; other site
767029001774	Q-loop/lid; other site
767029001775	ABC transporter signature motif; other site
767029001776	Walker B; other site
767029001777	D-loop; other site
767029001778	H-loop/switch region; other site
767029001779	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
767029001780	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
767029001781	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029001782	Walker A/P-loop; other site
767029001783	ATP binding site [chemical binding]; other site
767029001784	Q-loop/lid; other site
767029001785	ABC transporter signature motif; other site
767029001786	Walker B; other site
767029001787	D-loop; other site
767029001788	H-loop/switch region; other site
767029001789	Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316
767029001790	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
767029001791	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
767029001792	DNA binding residues [nucleotide binding]
767029001793	dimer interface [polypeptide binding]; other site
767029001794	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
767029001795	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
767029001796	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
767029001797	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
767029001798	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
767029001799	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
767029001800	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
767029001801	active site
767029001802	HIGH motif; other site
767029001803	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
767029001804	KMSKS motif; other site
767029001805	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
767029001806	tRNA binding surface [nucleotide binding]; other site
767029001807	anticodon binding site; other site
767029001808	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
767029001809	AAA domain; Region: AAA_14; pfam13173
767029001810	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
767029001811	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029001812	active site
767029001813	phosphorylation site [posttranslational modification]
767029001814	intermolecular recognition site; other site
767029001815	dimerization interface [polypeptide binding]; other site
767029001816	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
767029001817	DNA binding site [nucleotide binding]
767029001818	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
767029001819	HAMP domain; Region: HAMP; pfam00672
767029001820	dimerization interface [polypeptide binding]; other site
767029001821	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
767029001822	dimer interface [polypeptide binding]; other site
767029001823	phosphorylation site [posttranslational modification]
767029001824	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029001825	ATP binding site [chemical binding]; other site
767029001826	Mg2+ binding site [ion binding]; other site
767029001827	G-X-G motif; other site
767029001828	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
767029001829	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
767029001830	Multicopper oxidase; Region: Cu-oxidase; pfam00394
767029001831	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
767029001832	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
767029001833	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
767029001834	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
767029001835	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
767029001836	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
767029001837	Walker A motif; other site
767029001838	ATP binding site [chemical binding]; other site
767029001839	Walker B motif; other site
767029001840	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
767029001841	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
767029001842	S-adenosylmethionine binding site [chemical binding]; other site
767029001843	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
767029001844	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
767029001845	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
767029001846	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
767029001847	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
767029001848	FeS/SAM binding site; other site
767029001849	O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080
767029001850	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
767029001851	homodimer interface [polypeptide binding]; other site
767029001852	substrate-cofactor binding pocket; other site
767029001853	pyridoxal 5'-phosphate binding site [chemical binding]; other site
767029001854	catalytic residue [active]
767029001855	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
767029001856	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
767029001857	Walker A/P-loop; other site
767029001858	ATP binding site [chemical binding]; other site
767029001859	Q-loop/lid; other site
767029001860	ABC transporter signature motif; other site
767029001861	Walker B; other site
767029001862	D-loop; other site
767029001863	H-loop/switch region; other site
767029001864	TOBE domain; Region: TOBE_2; pfam08402
767029001865	Restriction endonuclease; Region: Mrr_cat; pfam04471
767029001866	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
767029001867	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
767029001868	S-adenosylmethionine binding site [chemical binding]; other site
767029001869	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
767029001870	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
767029001871	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
767029001872	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
767029001873	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
767029001874	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
767029001875	Coenzyme A binding pocket [chemical binding]; other site
767029001876	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
767029001877	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
767029001878	ring oligomerisation interface [polypeptide binding]; other site
767029001879	ATP/Mg binding site [chemical binding]; other site
767029001880	stacking interactions; other site
767029001881	hinge regions; other site
767029001882	CutC family; Region: CutC; cl01218
767029001883	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
767029001884	nudix motif; other site
767029001885	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
767029001886	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
767029001887	active site
767029001888	trimer interface [polypeptide binding]; other site
767029001889	allosteric site; other site
767029001890	active site lid [active]
767029001891	hexamer (dimer of trimers) interface [polypeptide binding]; other site
767029001892	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
767029001893	DNA-binding site [nucleotide binding]; DNA binding site
767029001894	RNA-binding motif; other site
767029001895	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
767029001896	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
767029001897	pyruvate carboxylase; Reviewed; Region: PRK12999
767029001898	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
767029001899	ATP-grasp domain; Region: ATP-grasp_4; cl17255
767029001900	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
767029001901	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
767029001902	active site
767029001903	catalytic residues [active]
767029001904	metal binding site [ion binding]; metal-binding site
767029001905	homodimer binding site [polypeptide binding]; other site
767029001906	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
767029001907	carboxyltransferase (CT) interaction site; other site
767029001908	biotinylation site [posttranslational modification]; other site
767029001909	phosphoserine aminotransferase; Provisional; Region: PRK03080
767029001910	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
767029001911	catalytic residue [active]
767029001912	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
767029001913	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
767029001914	active site
767029001915	dimer interface [polypeptide binding]; other site
767029001916	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
767029001917	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
767029001918	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
767029001919	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
767029001920	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
767029001921	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
767029001922	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
767029001923	catalytic residues [active]
767029001924	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
767029001925	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
767029001926	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
767029001927	4Fe-4S binding domain; Region: Fer4; pfam00037
767029001928	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
767029001929	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
767029001930	dimer interface [polypeptide binding]; other site
767029001931	PYR/PP interface [polypeptide binding]; other site
767029001932	TPP binding site [chemical binding]; other site
767029001933	substrate binding site [chemical binding]; other site
767029001934	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
767029001935	Domain of unknown function; Region: EKR; smart00890
767029001936	4Fe-4S binding domain; Region: Fer4_6; pfam12837
767029001937	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
767029001938	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
767029001939	TPP-binding site [chemical binding]; other site
767029001940	dimer interface [polypeptide binding]; other site
767029001941	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
767029001942	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
767029001943	phosphate binding site [ion binding]; other site
767029001944	Transcriptional regulators [Transcription]; Region: MarR; COG1846
767029001945	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
767029001946	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
767029001947	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
767029001948	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029001949	Walker A/P-loop; other site
767029001950	ATP binding site [chemical binding]; other site
767029001951	Q-loop/lid; other site
767029001952	ABC transporter signature motif; other site
767029001953	Walker B; other site
767029001954	D-loop; other site
767029001955	H-loop/switch region; other site
767029001956	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029001957	ABC-ATPase subunit interface; other site
767029001958	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
767029001959	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
767029001960	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
767029001961	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029001962	putative substrate translocation pore; other site
767029001963	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
767029001964	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
767029001965	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
767029001966	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
767029001967	DNA binding residues [nucleotide binding]
767029001968	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
767029001969	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
767029001970	putative NAD(P) binding site [chemical binding]; other site
767029001971	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
767029001972	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
767029001973	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
767029001974	FAD binding pocket [chemical binding]; other site
767029001975	conserved FAD binding motif [chemical binding]; other site
767029001976	phosphate binding motif [ion binding]; other site
767029001977	beta-alpha-beta structure motif; other site
767029001978	NAD binding pocket [chemical binding]; other site
767029001979	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029001980	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029001981	WHG domain; Region: WHG; pfam13305
767029001982	CsbD-like; Region: CsbD; cl17424
767029001983	D-serine dehydratase; Provisional; Region: PRK02991
767029001984	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
767029001985	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
767029001986	catalytic residue [active]
767029001987	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029001988	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029001989	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
767029001990	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
767029001991	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
767029001992	homotetramer interface [polypeptide binding]; other site
767029001993	FMN binding site [chemical binding]; other site
767029001994	homodimer contacts [polypeptide binding]; other site
767029001995	putative active site [active]
767029001996	putative substrate binding site [chemical binding]; other site
767029001997	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
767029001998	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
767029001999	diphosphomevalonate decarboxylase; Region: PLN02407
767029002000	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
767029002001	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
767029002002	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
767029002003	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
767029002004	ABC-ATPase subunit  interface; other site
767029002005	dimer interface [polypeptide binding]; other site
767029002006	putative PBP binding regions; other site
767029002007	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
767029002008	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
767029002009	ABC-ATPase subunit  interface; other site
767029002010	dimer interface [polypeptide binding]; other site
767029002011	putative PBP binding regions; other site
767029002012	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
767029002013	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
767029002014	siderophore binding site; other site
767029002015	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
767029002016	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
767029002017	Walker A/P-loop; other site
767029002018	ATP binding site [chemical binding]; other site
767029002019	Q-loop/lid; other site
767029002020	ABC transporter signature motif; other site
767029002021	Walker B; other site
767029002022	D-loop; other site
767029002023	H-loop/switch region; other site
767029002024	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
767029002025	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
767029002026	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
767029002027	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029002028	putative substrate translocation pore; other site
767029002029	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
767029002030	Predicted transcriptional regulator [Transcription]; Region: COG2345
767029002031	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
767029002032	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
767029002033	[4Fe-4S] binding site [ion binding]; other site
767029002034	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
767029002035	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
767029002036	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
767029002037	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
767029002038	molybdopterin cofactor binding site; other site
767029002039	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
767029002040	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
767029002041	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
767029002042	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
767029002043	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
767029002044	ATP binding site [chemical binding]; other site
767029002045	substrate interface [chemical binding]; other site
767029002046	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
767029002047	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
767029002048	dimer interface [polypeptide binding]; other site
767029002049	putative functional site; other site
767029002050	putative MPT binding site; other site
767029002051	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
767029002052	trimer interface [polypeptide binding]; other site
767029002053	dimer interface [polypeptide binding]; other site
767029002054	putative active site [active]
767029002055	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
767029002056	active site
767029002057	Ubiquitin-like proteins; Region: UBQ; cl00155
767029002058	charged pocket; other site
767029002059	hydrophobic patch; other site
767029002060	Transcriptional regulators [Transcription]; Region: PurR; COG1609
767029002061	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
767029002062	DNA binding site [nucleotide binding]
767029002063	domain linker motif; other site
767029002064	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
767029002065	ligand binding site [chemical binding]; other site
767029002066	dimerization interface (open form) [polypeptide binding]; other site
767029002067	dimerization interface (closed form) [polypeptide binding]; other site
767029002068	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_7; cd06316
767029002069	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
767029002070	putative ligand binding site [chemical binding]; other site
767029002071	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
767029002072	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
767029002073	Walker A/P-loop; other site
767029002074	ATP binding site [chemical binding]; other site
767029002075	Q-loop/lid; other site
767029002076	ABC transporter signature motif; other site
767029002077	Walker B; other site
767029002078	D-loop; other site
767029002079	H-loop/switch region; other site
767029002080	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
767029002081	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
767029002082	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
767029002083	TM-ABC transporter signature motif; other site
767029002084	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
767029002085	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
767029002086	conserved cys residue [active]
767029002087	Protein of unknown function (DUF1139); Region: DUF1139; pfam06599
767029002088	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
767029002089	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
767029002090	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
767029002091	intersubunit interface [polypeptide binding]; other site
767029002092	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
767029002093	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
767029002094	ABC-ATPase subunit  interface; other site
767029002095	dimer interface [polypeptide binding]; other site
767029002096	putative PBP binding regions; other site
767029002097	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
767029002098	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
767029002099	Walker A/P-loop; other site
767029002100	ATP binding site [chemical binding]; other site
767029002101	Q-loop/lid; other site
767029002102	ABC transporter signature motif; other site
767029002103	Walker B; other site
767029002104	D-loop; other site
767029002105	H-loop/switch region; other site
767029002106	Uncharacterized conserved protein [Function unknown]; Region: COG5620
767029002107	GAD-like domain; Region: GAD-like; pfam08887
767029002108	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
767029002109	FIC domain binding interface [polypeptide binding]; other site
767029002110	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029002111	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
767029002112	Walker A/P-loop; other site
767029002113	ATP binding site [chemical binding]; other site
767029002114	Q-loop/lid; other site
767029002115	ABC transporter signature motif; other site
767029002116	Walker B; other site
767029002117	D-loop; other site
767029002118	H-loop/switch region; other site
767029002119	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
767029002120	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029002121	dimer interface [polypeptide binding]; other site
767029002122	conserved gate region; other site
767029002123	putative PBP binding loops; other site
767029002124	ABC-ATPase subunit interface; other site
767029002125	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
767029002126	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
767029002127	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
767029002128	DNA binding residues [nucleotide binding]
767029002129	TOBE domain; Region: TOBE; cl01440
767029002130	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
767029002131	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
767029002132	FeS/SAM binding site; other site
767029002133	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
767029002134	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
767029002135	MoaE homodimer interface [polypeptide binding]; other site
767029002136	MoaD interaction [polypeptide binding]; other site
767029002137	active site residues [active]
767029002138	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
767029002139	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
767029002140	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
767029002141	Bacterial SH3 domain; Region: SH3_3; pfam08239
767029002142	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
767029002143	active site
767029002144	nucleophile elbow; other site
767029002145	Patatin-like phospholipase; Region: Patatin; pfam01734
767029002146	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
767029002147	Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324
767029002148	trehalose synthase; Region: treS_nterm; TIGR02456
767029002149	active site
767029002150	catalytic site [active]
767029002151	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
767029002152	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
767029002153	NAD(P) binding site [chemical binding]; other site
767029002154	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
767029002155	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029002156	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029002157	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
767029002158	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
767029002159	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
767029002160	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
767029002161	TM-ABC transporter signature motif; other site
767029002162	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
767029002163	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
767029002164	TM-ABC transporter signature motif; other site
767029002165	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
767029002166	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
767029002167	Walker A/P-loop; other site
767029002168	ATP binding site [chemical binding]; other site
767029002169	Q-loop/lid; other site
767029002170	ABC transporter signature motif; other site
767029002171	Walker B; other site
767029002172	D-loop; other site
767029002173	H-loop/switch region; other site
767029002174	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
767029002175	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
767029002176	Walker A/P-loop; other site
767029002177	ATP binding site [chemical binding]; other site
767029002178	Q-loop/lid; other site
767029002179	ABC transporter signature motif; other site
767029002180	Walker B; other site
767029002181	D-loop; other site
767029002182	H-loop/switch region; other site
767029002183	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
767029002184	urocanate hydratase; Provisional; Region: PRK05414
767029002185	Protein of unknown function (DUF917); Region: DUF917; pfam06032
767029002186	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
767029002187	active sites [active]
767029002188	tetramer interface [polypeptide binding]; other site
767029002189	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029002190	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029002191	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354
767029002192	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
767029002193	active site
767029002194	catalytic site [active]
767029002195	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
767029002196	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
767029002197	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029002198	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029002199	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
767029002200	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
767029002201	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
767029002202	NADH(P)-binding; Region: NAD_binding_10; pfam13460
767029002203	NAD(P) binding site [chemical binding]; other site
767029002204	active site
767029002205	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029002206	ABC transporter signature motif; other site
767029002207	Walker B; other site
767029002208	D-loop; other site
767029002209	H-loop/switch region; other site
767029002210	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
767029002211	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
767029002212	putative NAD(P) binding site [chemical binding]; other site
767029002213	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
767029002214	MarR family; Region: MarR_2; pfam12802
767029002215	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
767029002216	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
767029002217	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
767029002218	PEP synthetase regulatory protein; Provisional; Region: PRK05339
767029002219	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819
767029002220	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
767029002221	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
767029002222	Walker A/P-loop; other site
767029002223	ATP binding site [chemical binding]; other site
767029002224	Q-loop/lid; other site
767029002225	ABC transporter signature motif; other site
767029002226	Walker B; other site
767029002227	D-loop; other site
767029002228	H-loop/switch region; other site
767029002229	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
767029002230	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
767029002231	Walker A/P-loop; other site
767029002232	ATP binding site [chemical binding]; other site
767029002233	Q-loop/lid; other site
767029002234	ABC transporter signature motif; other site
767029002235	Walker B; other site
767029002236	D-loop; other site
767029002237	H-loop/switch region; other site
767029002238	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
767029002239	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
767029002240	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
767029002241	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
767029002242	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
767029002243	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
767029002244	Walker A motif; other site
767029002245	ATP binding site [chemical binding]; other site
767029002246	Walker B motif; other site
767029002247	SAF domain; Region: SAF; pfam08666
767029002248	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
767029002249	HPr interaction site; other site
767029002250	glycerol kinase (GK) interaction site [polypeptide binding]; other site
767029002251	active site
767029002252	phosphorylation site [posttranslational modification]
767029002253	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
767029002254	dimerization domain swap beta strand [polypeptide binding]; other site
767029002255	regulatory protein interface [polypeptide binding]; other site
767029002256	active site
767029002257	regulatory phosphorylation site [posttranslational modification]; other site
767029002258	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
767029002259	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
767029002260	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
767029002261	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
767029002262	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
767029002263	active site turn [active]
767029002264	phosphorylation site [posttranslational modification]
767029002265	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
767029002266	phosphotransferase system, EIIB; Region: PTS_EIIB; pfam00367
767029002267	active site turn [active]
767029002268	phosphorylation site [posttranslational modification]
767029002269	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
767029002270	active site
767029002271	catalytic residues [active]
767029002272	PA domain; Region: PA; pfam02225
767029002273	PA/protease or protease-like domain interface [polypeptide binding]; other site
767029002274	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
767029002275	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
767029002276	pyruvate phosphate dikinase; Provisional; Region: PRK09279
767029002277	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
767029002278	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
767029002279	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
767029002280	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
767029002281	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
767029002282	dimer interface [polypeptide binding]; other site
767029002283	substrate binding site [chemical binding]; other site
767029002284	ATP binding site [chemical binding]; other site
767029002285	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
767029002286	substrate binding site [chemical binding]; other site
767029002287	multimerization interface [polypeptide binding]; other site
767029002288	ATP binding site [chemical binding]; other site
767029002289	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
767029002290	putative active site [active]
767029002291	catalytic triad [active]
767029002292	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
767029002293	PA/protease or protease-like domain interface [polypeptide binding]; other site
767029002294	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
767029002295	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
767029002296	TIGR02677 family protein; Region: TIGR02677
767029002297	Protein of unknown function (DUF2397); Region: DUF2397; pfam09660
767029002298	Protein of unknown function (DUF2398); Region: DUF2398; cl09875
767029002299	Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664
767029002300	Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664
767029002301	Restriction endonuclease; Region: Mrr_cat; pfam04471
767029002302	ATP-grasp domain; Region: ATP-grasp_4; cl17255
767029002303	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
767029002304	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
767029002305	ATP binding site [chemical binding]; other site
767029002306	putative Mg++ binding site [ion binding]; other site
767029002307	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
767029002308	nucleotide binding region [chemical binding]; other site
767029002309	ATP-binding site [chemical binding]; other site
767029002310	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
767029002311	active site
767029002312	substrate-binding site [chemical binding]; other site
767029002313	metal-binding site [ion binding]
767029002314	GTP binding site [chemical binding]; other site
767029002315	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
767029002316	Clp amino terminal domain; Region: Clp_N; pfam02861
767029002317	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
767029002318	Walker A motif; other site
767029002319	ATP binding site [chemical binding]; other site
767029002320	Walker B motif; other site
767029002321	arginine finger; other site
767029002322	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
767029002323	Walker A motif; other site
767029002324	ATP binding site [chemical binding]; other site
767029002325	Walker B motif; other site
767029002326	arginine finger; other site
767029002327	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
767029002328	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
767029002329	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
767029002330	AsnC family; Region: AsnC_trans_reg; pfam01037
767029002331	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
767029002332	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
767029002333	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
767029002334	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
767029002335	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
767029002336	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
767029002337	catalytic residue [active]
767029002338	D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043
767029002339	D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043
767029002340	B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067
767029002341	B12 binding site [chemical binding]; other site
767029002342	cobalt ligand [ion binding]; other site
767029002343	MutL protein; Region: MutL; pfam13941
767029002344	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
767029002345	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
767029002346	active site
767029002347	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
767029002348	dimer interface [polypeptide binding]; other site
767029002349	substrate binding site [chemical binding]; other site
767029002350	catalytic residue [active]
767029002351	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
767029002352	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
767029002353	TrkA-N domain; Region: TrkA_N; pfam02254
767029002354	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
767029002355	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
767029002356	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
767029002357	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
767029002358	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
767029002359	FOG: WD40 repeat [General function prediction only]; Region: COG2319
767029002360	structural tetrad; other site
767029002361	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
767029002362	Interdomain contacts; other site
767029002363	Cytokine receptor motif; other site
767029002364	MoxR-like ATPases [General function prediction only]; Region: COG0714
767029002365	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
767029002366	Walker A motif; other site
767029002367	ATP binding site [chemical binding]; other site
767029002368	Walker B motif; other site
767029002369	arginine finger; other site
767029002370	CARDB; Region: CARDB; pfam07705
767029002371	Protein of unknown function DUF58; Region: DUF58; pfam01882
767029002372	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
767029002373	phosphopeptide binding site; other site
767029002374	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
767029002375	Catalytic domain of Protein Kinases; Region: PKc; cd00180
767029002376	active site
767029002377	ATP binding site [chemical binding]; other site
767029002378	substrate binding site [chemical binding]; other site
767029002379	activation loop (A-loop); other site
767029002380	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
767029002381	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
767029002382	active site
767029002383	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
767029002384	Domain of unknown function (DUF368); Region: DUF368; pfam04018
767029002385	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
767029002386	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
767029002387	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
767029002388	active site
767029002389	intersubunit interface [polypeptide binding]; other site
767029002390	zinc binding site [ion binding]; other site
767029002391	Na+ binding site [ion binding]; other site
767029002392	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
767029002393	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
767029002394	Walker A/P-loop; other site
767029002395	ATP binding site [chemical binding]; other site
767029002396	Q-loop/lid; other site
767029002397	ABC transporter signature motif; other site
767029002398	Walker B; other site
767029002399	D-loop; other site
767029002400	H-loop/switch region; other site
767029002401	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
767029002402	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
767029002403	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
767029002404	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
767029002405	TM-ABC transporter signature motif; other site
767029002406	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
767029002407	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
767029002408	putative ligand binding site [chemical binding]; other site
767029002409	L-fucose isomerase; Provisional; Region: fucI; PRK10991
767029002410	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
767029002411	hexamer (dimer of trimers) interface [polypeptide binding]; other site
767029002412	trimer interface [polypeptide binding]; other site
767029002413	substrate binding site [chemical binding]; other site
767029002414	Mn binding site [ion binding]; other site
767029002415	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
767029002416	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
767029002417	nucleotide binding site [chemical binding]; other site
767029002418	Transcriptional regulators [Transcription]; Region: PurR; COG1609
767029002419	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
767029002420	DNA binding site [nucleotide binding]
767029002421	domain linker motif; other site
767029002422	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
767029002423	RbsD / FucU transport protein family; Region: RbsD_FucU; pfam05025
767029002424	TIGR03085 family protein; Region: TIGR03085
767029002425	serine acetyltransferase; Provisional; Region: cysE; PRK11132
767029002426	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
767029002427	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
767029002428	trimer interface [polypeptide binding]; other site
767029002429	active site
767029002430	substrate binding site [chemical binding]; other site
767029002431	CoA binding site [chemical binding]; other site
767029002432	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
767029002433	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
767029002434	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
767029002435	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
767029002436	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
767029002437	carboxyltransferase (CT) interaction site; other site
767029002438	biotinylation site [posttranslational modification]; other site
767029002439	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
767029002440	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029002441	active site
767029002442	phosphorylation site [posttranslational modification]
767029002443	intermolecular recognition site; other site
767029002444	dimerization interface [polypeptide binding]; other site
767029002445	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029002446	DNA binding residues [nucleotide binding]
767029002447	dimerization interface [polypeptide binding]; other site
767029002448	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
767029002449	Histidine kinase; Region: HisKA_3; pfam07730
767029002450	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
767029002451	ATP binding site [chemical binding]; other site
767029002452	Mg2+ binding site [ion binding]; other site
767029002453	G-X-G motif; other site
767029002454	CAAX protease self-immunity; Region: Abi; pfam02517
767029002455	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
767029002456	nudix motif; other site
767029002457	DivIVA protein; Region: DivIVA; pfam05103
767029002458	Maf-like protein; Region: Maf; pfam02545
767029002459	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
767029002460	active site
767029002461	dimer interface [polypeptide binding]; other site
767029002462	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
767029002463	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
767029002464	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
767029002465	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
767029002466	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
767029002467	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
767029002468	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
767029002469	Bacterial PH domain; Region: DUF304; pfam03703
767029002470	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
767029002471	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
767029002472	ATP-grasp domain; Region: ATP-grasp; pfam02222
767029002473	AIR carboxylase; Region: AIRC; pfam00731
767029002474	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
767029002475	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
767029002476	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
767029002477	Transcriptional regulator [Transcription]; Region: LytR; COG1316
767029002478	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
767029002479	ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525
767029002480	Ligand binding site; other site
767029002481	TIGR03089 family protein; Region: TIGR03089
767029002482	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
767029002483	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
767029002484	Substrate binding site; other site
767029002485	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
767029002486	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
767029002487	active site
767029002488	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
767029002489	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
767029002490	Walker A/P-loop; other site
767029002491	ATP binding site [chemical binding]; other site
767029002492	Q-loop/lid; other site
767029002493	ABC transporter signature motif; other site
767029002494	Walker B; other site
767029002495	D-loop; other site
767029002496	H-loop/switch region; other site
767029002497	ABC-2 type transporter; Region: ABC2_membrane; cl17235
767029002498	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
767029002499	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
767029002500	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
767029002501	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
767029002502	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
767029002503	active site
767029002504	substrate binding site [chemical binding]; other site
767029002505	metal binding site [ion binding]; metal-binding site
767029002506	Uncharacterized conserved protein [Function unknown]; Region: COG2835
767029002507	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
767029002508	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
767029002509	homotetramer interface [polypeptide binding]; other site
767029002510	ligand binding site [chemical binding]; other site
767029002511	catalytic site [active]
767029002512	NAD binding site [chemical binding]; other site
767029002513	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
767029002514	Major Facilitator Superfamily; Region: MFS_1; pfam07690
767029002515	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029002516	putative substrate translocation pore; other site
767029002517	RDD family; Region: RDD; pfam06271
767029002518	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
767029002519	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
767029002520	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
767029002521	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
767029002522	active site
767029002523	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
767029002524	glutamate racemase; Provisional; Region: PRK00865
767029002525	ribonuclease PH; Reviewed; Region: rph; PRK00173
767029002526	Ribonuclease PH; Region: RNase_PH_bact; cd11362
767029002527	hexamer interface [polypeptide binding]; other site
767029002528	active site
767029002529	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
767029002530	active site
767029002531	dimerization interface [polypeptide binding]; other site
767029002532	thymidylate synthase; Reviewed; Region: thyA; PRK01827
767029002533	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
767029002534	dimerization interface [polypeptide binding]; other site
767029002535	active site
767029002536	MoxR-like ATPases [General function prediction only]; Region: COG0714
767029002537	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
767029002538	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
767029002539	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
767029002540	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
767029002541	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
767029002542	metal ion-dependent adhesion site (MIDAS); other site
767029002543	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
767029002544	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
767029002545	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
767029002546	folate binding site [chemical binding]; other site
767029002547	NADP+ binding site [chemical binding]; other site
767029002548	DNA polymerase IV; Provisional; Region: PRK03348
767029002549	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
767029002550	active site
767029002551	DNA binding site [nucleotide binding]
767029002552	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
767029002553	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
767029002554	substrate-cofactor binding pocket; other site
767029002555	pyridoxal 5'-phosphate binding site [chemical binding]; other site
767029002556	catalytic residue [active]
767029002557	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
767029002558	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
767029002559	NAD(P) binding site [chemical binding]; other site
767029002560	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
767029002561	hypothetical protein; Provisional; Region: PRK06771
767029002562	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
767029002563	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
767029002564	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
767029002565	BCCT family transporter; Region: BCCT; pfam02028
767029002566	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
767029002567	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
767029002568	alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382
767029002569	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
767029002570	catalytic triad [active]
767029002571	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
767029002572	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
767029002573	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
767029002574	putative Iron-sulfur protein interface [polypeptide binding]; other site
767029002575	proximal heme binding site [chemical binding]; other site
767029002576	distal heme binding site [chemical binding]; other site
767029002577	putative dimer interface [polypeptide binding]; other site
767029002578	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
767029002579	L-aspartate oxidase; Provisional; Region: PRK06175
767029002580	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
767029002581	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
767029002582	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
767029002583	biotin synthase; Validated; Region: PRK06256
767029002584	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
767029002585	FeS/SAM binding site; other site
767029002586	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
767029002587	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
767029002588	non-specific DNA binding site [nucleotide binding]; other site
767029002589	salt bridge; other site
767029002590	sequence-specific DNA binding site [nucleotide binding]; other site
767029002591	Predicted flavoprotein [General function prediction only]; Region: COG0431
767029002592	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
767029002593	ATP-grasp domain; Region: ATP-grasp_4; cl17255
767029002594	ATP-grasp domain; Region: ATP-grasp_4; cl17255
767029002595	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
767029002596	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
767029002597	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029002598	Major Facilitator Superfamily; Region: MFS_1; pfam07690
767029002599	putative substrate translocation pore; other site
767029002600	ATP-grasp domain; Region: ATP-grasp_4; cl17255
767029002601	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
767029002602	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
767029002603	catalytic Zn binding site [ion binding]; other site
767029002604	NAD(P) binding site [chemical binding]; other site
767029002605	structural Zn binding site [ion binding]; other site
767029002606	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
767029002607	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
767029002608	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
767029002609	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
767029002610	DNA binding residues [nucleotide binding]
767029002611	dimer interface [polypeptide binding]; other site
767029002612	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
767029002613	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
767029002614	DNA binding residues [nucleotide binding]
767029002615	acyl carrier protein; Validated; Region: PRK07117
767029002616	Acyl transferase domain; Region: Acyl_transf_1; cl08282
767029002617	polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103
767029002618	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
767029002619	active site
767029002620	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
767029002621	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
767029002622	O-methyltransferase; Region: Methyltransf_2; pfam00891
767029002623	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
767029002624	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
767029002625	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
767029002626	FMN binding site [chemical binding]; other site
767029002627	substrate binding site [chemical binding]; other site
767029002628	putative catalytic residue [active]
767029002629	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
767029002630	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
767029002631	substrate binding site [chemical binding]; other site
767029002632	oxyanion hole (OAH) forming residues; other site
767029002633	trimer interface [polypeptide binding]; other site
767029002634	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
767029002635	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
767029002636	acyl-activating enzyme (AAE) consensus motif; other site
767029002637	AMP binding site [chemical binding]; other site
767029002638	active site
767029002639	CoA binding site [chemical binding]; other site
767029002640	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
767029002641	putative NADP binding site [chemical binding]; other site
767029002642	KR domain; Region: KR; pfam08659
767029002643	active site
767029002644	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
767029002645	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
767029002646	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
767029002647	active site
767029002648	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
767029002649	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
767029002650	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
767029002651	active site
767029002652	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
767029002653	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
767029002654	active site
767029002655	Acyl transferase domain; Region: Acyl_transf_1; cl08282
767029002656	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
767029002657	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
767029002658	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
767029002659	3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425
767029002660	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
767029002661	dimer interface [polypeptide binding]; other site
767029002662	active site
767029002663	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
767029002664	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
767029002665	substrate binding site [chemical binding]; other site
767029002666	oxyanion hole (OAH) forming residues; other site
767029002667	trimer interface [polypeptide binding]; other site
767029002668	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
767029002669	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
767029002670	NAD(P) binding site [chemical binding]; other site
767029002671	active site
767029002672	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
767029002673	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029002674	Walker A/P-loop; other site
767029002675	ATP binding site [chemical binding]; other site
767029002676	Q-loop/lid; other site
767029002677	ABC transporter signature motif; other site
767029002678	Walker B; other site
767029002679	D-loop; other site
767029002680	H-loop/switch region; other site
767029002681	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
767029002682	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
767029002683	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
767029002684	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
767029002685	Coenzyme A binding pocket [chemical binding]; other site
767029002686	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
767029002687	active site
767029002688	catalytic site [active]
767029002689	Zn binding site [ion binding]; other site
767029002690	tetramer interface [polypeptide binding]; other site
767029002691	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
767029002692	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
767029002693	active site
767029002694	homotetramer interface [polypeptide binding]; other site
767029002695	homodimer interface [polypeptide binding]; other site
767029002696	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029002697	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
767029002698	dimerization interface [polypeptide binding]; other site
767029002699	DNA binding residues [nucleotide binding]
767029002700	PemK-like protein; Region: PemK; pfam02452
767029002701	amidase; Provisional; Region: PRK12470
767029002702	Amidase; Region: Amidase; cl11426
767029002703	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
767029002704	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
767029002705	catalytic site [active]
767029002706	putative active site [active]
767029002707	putative substrate binding site [chemical binding]; other site
767029002708	dimer interface [polypeptide binding]; other site
767029002709	Protease prsW family; Region: PrsW-protease; pfam13367
767029002710	Dynamin family; Region: Dynamin_N; pfam00350
767029002711	YfjP GTPase; Region: YfjP; cd11383
767029002712	G1 box; other site
767029002713	GTP/Mg2+ binding site [chemical binding]; other site
767029002714	Switch I region; other site
767029002715	G2 box; other site
767029002716	Switch II region; other site
767029002717	G3 box; other site
767029002718	G4 box; other site
767029002719	G5 box; other site
767029002720	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
767029002721	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029002722	Walker A/P-loop; other site
767029002723	ATP binding site [chemical binding]; other site
767029002724	Q-loop/lid; other site
767029002725	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
767029002726	ABC transporter; Region: ABC_tran_2; pfam12848
767029002727	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
767029002728	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
767029002729	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
767029002730	GIY-YIG motif/motif A; other site
767029002731	active site
767029002732	catalytic site [active]
767029002733	putative DNA binding site [nucleotide binding]; other site
767029002734	metal binding site [ion binding]; metal-binding site
767029002735	UvrB/uvrC motif; Region: UVR; pfam02151
767029002736	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
767029002737	Helix-hairpin-helix motif; Region: HHH; pfam00633
767029002738	H+ Antiporter protein; Region: 2A0121; TIGR00900
767029002739	BioY family; Region: BioY; pfam02632
767029002740	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
767029002741	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
767029002742	Walker A/P-loop; other site
767029002743	ATP binding site [chemical binding]; other site
767029002744	Q-loop/lid; other site
767029002745	ABC transporter signature motif; other site
767029002746	Walker B; other site
767029002747	D-loop; other site
767029002748	H-loop/switch region; other site
767029002749	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
767029002750	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
767029002751	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
767029002752	phosphate binding site [ion binding]; other site
767029002753	putative substrate binding pocket [chemical binding]; other site
767029002754	dimer interface [polypeptide binding]; other site
767029002755	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
767029002756	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
767029002757	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
767029002758	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
767029002759	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
767029002760	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
767029002761	Phosphoglycerate kinase; Region: PGK; pfam00162
767029002762	substrate binding site [chemical binding]; other site
767029002763	hinge regions; other site
767029002764	ADP binding site [chemical binding]; other site
767029002765	catalytic site [active]
767029002766	triosephosphate isomerase; Provisional; Region: PRK14567
767029002767	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
767029002768	substrate binding site [chemical binding]; other site
767029002769	dimer interface [polypeptide binding]; other site
767029002770	catalytic triad [active]
767029002771	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
767029002772	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
767029002773	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
767029002774	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
767029002775	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
767029002776	Coenzyme A binding pocket [chemical binding]; other site
767029002777	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
767029002778	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
767029002779	putative active site [active]
767029002780	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
767029002781	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
767029002782	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
767029002783	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
767029002784	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
767029002785	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
767029002786	Predicted transcriptional regulator [Transcription]; Region: COG2345
767029002787	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
767029002788	putative DNA binding site [nucleotide binding]; other site
767029002789	putative Zn2+ binding site [ion binding]; other site
767029002790	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
767029002791	FeS assembly protein SufB; Region: sufB; TIGR01980
767029002792	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
767029002793	FeS assembly protein SufD; Region: sufD; TIGR01981
767029002794	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
767029002795	[2Fe-2S] cluster binding site [ion binding]; other site
767029002796	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
767029002797	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
767029002798	Walker A/P-loop; other site
767029002799	ATP binding site [chemical binding]; other site
767029002800	Q-loop/lid; other site
767029002801	ABC transporter signature motif; other site
767029002802	Walker B; other site
767029002803	D-loop; other site
767029002804	H-loop/switch region; other site
767029002805	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
767029002806	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
767029002807	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
767029002808	catalytic residue [active]
767029002809	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
767029002810	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
767029002811	trimerization site [polypeptide binding]; other site
767029002812	active site
767029002813	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
767029002814	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
767029002815	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
767029002816	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
767029002817	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
767029002818	Short C-terminal domain; Region: SHOCT; pfam09851
767029002819	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
767029002820	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
767029002821	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
767029002822	ABC transporter; Region: ABC_tran_2; pfam12848
767029002823	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
767029002824	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
767029002825	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
767029002826	active site
767029002827	substrate binding site [chemical binding]; other site
767029002828	metal binding site [ion binding]; metal-binding site
767029002829	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
767029002830	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
767029002831	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
767029002832	S-adenosylmethionine binding site [chemical binding]; other site
767029002833	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
767029002834	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
767029002835	NAD(P) binding site [chemical binding]; other site
767029002836	active site
767029002837	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
767029002838	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
767029002839	NAD(P) binding site [chemical binding]; other site
767029002840	active site
767029002841	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
767029002842	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029002843	Walker A/P-loop; other site
767029002844	ATP binding site [chemical binding]; other site
767029002845	ABC transporter signature motif; other site
767029002846	Walker B; other site
767029002847	D-loop; other site
767029002848	H-loop/switch region; other site
767029002849	fumarate hydratase; Reviewed; Region: fumC; PRK00485
767029002850	Class II fumarases; Region: Fumarase_classII; cd01362
767029002851	active site
767029002852	tetramer interface [polypeptide binding]; other site
767029002853	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
767029002854	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
767029002855	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
767029002856	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
767029002857	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
767029002858	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
767029002859	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
767029002860	generic binding surface I; other site
767029002861	generic binding surface II; other site
767029002862	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
767029002863	putative active site [active]
767029002864	putative catalytic site [active]
767029002865	putative Mg binding site IVb [ion binding]; other site
767029002866	putative phosphate binding site [ion binding]; other site
767029002867	putative DNA binding site [nucleotide binding]; other site
767029002868	putative Mg binding site IVa [ion binding]; other site
767029002869	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
767029002870	active site
767029002871	catalytic residues [active]
767029002872	metal binding site [ion binding]; metal-binding site
767029002873	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
767029002874	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
767029002875	active site
767029002876	DNA binding site [nucleotide binding]
767029002877	Int/Topo IB signature motif; other site
767029002878	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
767029002879	Peptidase family M23; Region: Peptidase_M23; pfam01551
767029002880	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
767029002881	Peptidase family M23; Region: Peptidase_M23; pfam01551
767029002882	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
767029002883	rRNA interaction site [nucleotide binding]; other site
767029002884	S8 interaction site; other site
767029002885	putative laminin-1 binding site; other site
767029002886	elongation factor Ts; Provisional; Region: tsf; PRK09377
767029002887	UBA/TS-N domain; Region: UBA; pfam00627
767029002888	Elongation factor TS; Region: EF_TS; pfam00889
767029002889	Elongation factor TS; Region: EF_TS; pfam00889
767029002890	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
767029002891	putative nucleotide binding site [chemical binding]; other site
767029002892	uridine monophosphate binding site [chemical binding]; other site
767029002893	homohexameric interface [polypeptide binding]; other site
767029002894	ribosome recycling factor; Reviewed; Region: frr; PRK00083
767029002895	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
767029002896	hinge region; other site
767029002897	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
767029002898	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
767029002899	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
767029002900	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
767029002901	FeS/SAM binding site; other site
767029002902	glutamate dehydrogenase; Provisional; Region: PRK09414
767029002903	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
767029002904	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
767029002905	NAD(P) binding site [chemical binding]; other site
767029002906	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
767029002907	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
767029002908	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
767029002909	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
767029002910	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
767029002911	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
767029002912	active site
767029002913	putative substrate binding region [chemical binding]; other site
767029002914	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
767029002915	protein binding site [polypeptide binding]; other site
767029002916	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
767029002917	homotrimer interface [polypeptide binding]; other site
767029002918	Walker A motif; other site
767029002919	GTP binding site [chemical binding]; other site
767029002920	Walker B motif; other site
767029002921	cobalamin synthase; Reviewed; Region: cobS; PRK00235
767029002922	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
767029002923	cobyric acid synthase; Provisional; Region: PRK00784
767029002924	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
767029002925	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
767029002926	catalytic triad [active]
767029002927	AAA domain; Region: AAA_14; pfam13173
767029002928	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
767029002929	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
767029002930	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
767029002931	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
767029002932	putative active site [active]
767029002933	putative substrate binding site [chemical binding]; other site
767029002934	putative cosubstrate binding site; other site
767029002935	catalytic site [active]
767029002936	Domain of unknown function DUF21; Region: DUF21; pfam01595
767029002937	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
767029002938	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
767029002939	Transporter associated domain; Region: CorC_HlyC; smart01091
767029002940	Phosphotransferase enzyme family; Region: APH; pfam01636
767029002941	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
767029002942	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
767029002943	ligand binding site [chemical binding]; other site
767029002944	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
767029002945	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
767029002946	Walker A/P-loop; other site
767029002947	ATP binding site [chemical binding]; other site
767029002948	Q-loop/lid; other site
767029002949	ABC transporter signature motif; other site
767029002950	Walker B; other site
767029002951	D-loop; other site
767029002952	H-loop/switch region; other site
767029002953	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
767029002954	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
767029002955	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
767029002956	TM-ABC transporter signature motif; other site
767029002957	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
767029002958	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
767029002959	TM-ABC transporter signature motif; other site
767029002960	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
767029002961	active site
767029002962	catalytic motif [active]
767029002963	Zn binding site [ion binding]; other site
767029002964	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
767029002965	adenosine deaminase; Provisional; Region: PRK09358
767029002966	active site
767029002967	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
767029002968	RNA/DNA hybrid binding site [nucleotide binding]; other site
767029002969	active site
767029002970	Uncharacterized conserved protein [Function unknown]; Region: COG2966
767029002971	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
767029002972	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
767029002973	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
767029002974	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
767029002975	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029002976	Walker A/P-loop; other site
767029002977	ATP binding site [chemical binding]; other site
767029002978	Q-loop/lid; other site
767029002979	ABC transporter signature motif; other site
767029002980	Walker B; other site
767029002981	D-loop; other site
767029002982	H-loop/switch region; other site
767029002983	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
767029002984	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
767029002985	active site
767029002986	HIGH motif; other site
767029002987	KMSKS motif; other site
767029002988	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
767029002989	tRNA binding surface [nucleotide binding]; other site
767029002990	anticodon binding site; other site
767029002991	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
767029002992	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
767029002993	TIGR04222 domain; Region: near_uncomplex
767029002994	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
767029002995	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
767029002996	active site
767029002997	substrate binding site [chemical binding]; other site
767029002998	metal binding site [ion binding]; metal-binding site
767029002999	purine nucleoside phosphorylase; Provisional; Region: PRK08202
767029003000	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
767029003001	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
767029003002	ATP binding site [chemical binding]; other site
767029003003	putative Mg++ binding site [ion binding]; other site
767029003004	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
767029003005	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
767029003006	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
767029003007	active site
767029003008	catalytic site [active]
767029003009	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
767029003010	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
767029003011	nudix motif; other site
767029003012	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
767029003013	ATP binding site [chemical binding]; other site
767029003014	putative Mg++ binding site [ion binding]; other site
767029003015	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
767029003016	nucleotide binding region [chemical binding]; other site
767029003017	ATP-binding site [chemical binding]; other site
767029003018	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
767029003019	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
767029003020	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
767029003021	NAD binding site [chemical binding]; other site
767029003022	catalytic Zn binding site [ion binding]; other site
767029003023	substrate binding site [chemical binding]; other site
767029003024	structural Zn binding site [ion binding]; other site
767029003025	SWIM zinc finger; Region: SWIM; pfam04434
767029003026	MoxR-like ATPases [General function prediction only]; Region: COG0714
767029003027	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
767029003028	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
767029003029	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
767029003030	metal ion-dependent adhesion site (MIDAS); other site
767029003031	benzoate transport; Region: 2A0115; TIGR00895
767029003032	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029003033	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029003034	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
767029003035	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
767029003036	substrate binding site [chemical binding]; other site
767029003037	ATP binding site [chemical binding]; other site
767029003038	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
767029003039	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
767029003040	intersubunit interface [polypeptide binding]; other site
767029003041	active site
767029003042	Zn2+ binding site [ion binding]; other site
767029003043	L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209
767029003044	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
767029003045	AP (apurinic/apyrimidinic) site pocket; other site
767029003046	DNA interaction; other site
767029003047	Metal-binding active site; metal-binding site
767029003048	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
767029003049	active site
767029003050	dimer interface [polypeptide binding]; other site
767029003051	magnesium binding site [ion binding]; other site
767029003052	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
767029003053	active site
767029003054	substrate binding pocket [chemical binding]; other site
767029003055	homodimer interaction site [polypeptide binding]; other site
767029003056	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
767029003057	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
767029003058	DNA binding residues [nucleotide binding]
767029003059	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
767029003060	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
767029003061	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
767029003062	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
767029003063	Coenzyme A binding pocket [chemical binding]; other site
767029003064	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
767029003065	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
767029003066	active site
767029003067	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
767029003068	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
767029003069	TPP-binding site [chemical binding]; other site
767029003070	dimer interface [polypeptide binding]; other site
767029003071	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
767029003072	PYR/PP interface [polypeptide binding]; other site
767029003073	dimer interface [polypeptide binding]; other site
767029003074	TPP binding site [chemical binding]; other site
767029003075	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
767029003076	tandem repeat interface [polypeptide binding]; other site
767029003077	oligomer interface [polypeptide binding]; other site
767029003078	active site residues [active]
767029003079	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
767029003080	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
767029003081	tandem repeat interface [polypeptide binding]; other site
767029003082	oligomer interface [polypeptide binding]; other site
767029003083	active site residues [active]
767029003084	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
767029003085	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
767029003086	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
767029003087	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
767029003088	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029003089	Major Facilitator Superfamily; Region: MFS_1; pfam07690
767029003090	putative substrate translocation pore; other site
767029003091	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
767029003092	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
767029003093	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
767029003094	VanW like protein; Region: VanW; pfam04294
767029003095	Ferredoxin [Energy production and conversion]; Region: COG1146
767029003096	4Fe-4S binding domain; Region: Fer4; pfam00037
767029003097	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
767029003098	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
767029003099	pyridoxal 5'-phosphate binding site [chemical binding]; other site
767029003100	homodimer interface [polypeptide binding]; other site
767029003101	catalytic residue [active]
767029003102	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137
767029003103	reactive center loop; other site
767029003104	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
767029003105	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
767029003106	putative trimer interface [polypeptide binding]; other site
767029003107	putative CoA binding site [chemical binding]; other site
767029003108	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
767029003109	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
767029003110	metal binding site [ion binding]; metal-binding site
767029003111	putative dimer interface [polypeptide binding]; other site
767029003112	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
767029003113	DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543
767029003114	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
767029003115	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
767029003116	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
767029003117	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
767029003118	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
767029003119	ligand binding site; other site
767029003120	oligomer interface; other site
767029003121	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
767029003122	dimer interface [polypeptide binding]; other site
767029003123	N-terminal domain interface [polypeptide binding]; other site
767029003124	sulfate 1 binding site; other site
767029003125	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
767029003126	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
767029003127	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
767029003128	dimer interface [polypeptide binding]; other site
767029003129	active site
767029003130	catalytic residue [active]
767029003131	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
767029003132	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
767029003133	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
767029003134	DNA binding residues [nucleotide binding]
767029003135	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
767029003136	sec-independent translocase; Provisional; Region: PRK01371
767029003137	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
767029003138	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
767029003139	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
767029003140	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
767029003141	PRC-barrel domain; Region: PRC; pfam05239
767029003142	MgtE intracellular N domain; Region: MgtE_N; smart00924
767029003143	FOG: CBS domain [General function prediction only]; Region: COG0517
767029003144	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
767029003145	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
767029003146	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
767029003147	proline aminopeptidase P II; Provisional; Region: PRK10879
767029003148	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
767029003149	active site
767029003150	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
767029003151	Putative zinc ribbon domain; Region: DUF164; pfam02591
767029003152	RNB domain; Region: RNB; pfam00773
767029003153	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
767029003154	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
767029003155	active site
767029003156	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
767029003157	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
767029003158	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
767029003159	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
767029003160	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
767029003161	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
767029003162	metal binding triad; other site
767029003163	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
767029003164	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
767029003165	metal binding triad; other site
767029003166	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
767029003167	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029003168	dimer interface [polypeptide binding]; other site
767029003169	conserved gate region; other site
767029003170	putative PBP binding loops; other site
767029003171	ABC-ATPase subunit interface; other site
767029003172	NMT1/THI5 like; Region: NMT1; pfam09084
767029003173	phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417
767029003174	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
767029003175	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
767029003176	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
767029003177	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
767029003178	dimerization domain swap beta strand [polypeptide binding]; other site
767029003179	regulatory protein interface [polypeptide binding]; other site
767029003180	active site
767029003181	regulatory phosphorylation site [posttranslational modification]; other site
767029003182	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
767029003183	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
767029003184	putative substrate binding site [chemical binding]; other site
767029003185	putative ATP binding site [chemical binding]; other site
767029003186	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
767029003187	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
767029003188	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
767029003189	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
767029003190	L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235
767029003191	putative NAD(P) binding site [chemical binding]; other site
767029003192	catalytic Zn binding site [ion binding]; other site
767029003193	MMPL family; Region: MMPL; pfam03176
767029003194	glutamine synthetase, type I; Region: GlnA; TIGR00653
767029003195	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
767029003196	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
767029003197	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
767029003198	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
767029003199	Walker A/P-loop; other site
767029003200	ATP binding site [chemical binding]; other site
767029003201	Q-loop/lid; other site
767029003202	ABC transporter signature motif; other site
767029003203	Walker B; other site
767029003204	D-loop; other site
767029003205	H-loop/switch region; other site
767029003206	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
767029003207	ABC-2 type transporter; Region: ABC2_membrane; cl17235
767029003208	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
767029003209	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
767029003210	non-specific DNA binding site [nucleotide binding]; other site
767029003211	salt bridge; other site
767029003212	sequence-specific DNA binding site [nucleotide binding]; other site
767029003213	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029003214	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029003215	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
767029003216	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
767029003217	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
767029003218	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
767029003219	Walker A/P-loop; other site
767029003220	ATP binding site [chemical binding]; other site
767029003221	Q-loop/lid; other site
767029003222	ABC transporter signature motif; other site
767029003223	Walker B; other site
767029003224	D-loop; other site
767029003225	H-loop/switch region; other site
767029003226	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
767029003227	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
767029003228	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
767029003229	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
767029003230	active site
767029003231	P-loop; other site
767029003232	phosphorylation site [posttranslational modification]
767029003233	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
767029003234	active site
767029003235	phosphorylation site [posttranslational modification]
767029003236	hypothetical protein; Provisional; Region: PRK02947
767029003237	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
767029003238	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
767029003239	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
767029003240	DNA-binding site [nucleotide binding]; DNA binding site
767029003241	UTRA domain; Region: UTRA; pfam07702
767029003242	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
767029003243	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
767029003244	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
767029003245	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
767029003246	lipoyl synthase; Provisional; Region: PRK05481
767029003247	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
767029003248	FeS/SAM binding site; other site
767029003249	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
767029003250	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
767029003251	Precorrin-8X methylmutase; Region: CbiC; pfam02570
767029003252	cobalt transport protein CbiM; Validated; Region: PRK08319
767029003253	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
767029003254	cobalt transport protein CbiN; Provisional; Region: PRK02898
767029003255	Cobalt transport protein; Region: CbiQ; cl00463
767029003256	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
767029003257	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
767029003258	Walker A/P-loop; other site
767029003259	ATP binding site [chemical binding]; other site
767029003260	Q-loop/lid; other site
767029003261	ABC transporter signature motif; other site
767029003262	Walker B; other site
767029003263	D-loop; other site
767029003264	H-loop/switch region; other site
767029003265	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
767029003266	Tic20-like protein; Region: Tic20; pfam09685
767029003267	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
767029003268	active site
767029003269	putative homodimer interface [polypeptide binding]; other site
767029003270	SAM binding site [chemical binding]; other site
767029003271	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
767029003272	Methyltransferase domain; Region: Methyltransf_18; pfam12847
767029003273	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
767029003274	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
767029003275	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
767029003276	homodimer interface [polypeptide binding]; other site
767029003277	Walker A motif; other site
767029003278	ATP binding site [chemical binding]; other site
767029003279	hydroxycobalamin binding site [chemical binding]; other site
767029003280	Walker B motif; other site
767029003281	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
767029003282	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
767029003283	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
767029003284	catalytic triad [active]
767029003285	hypothetical protein; Provisional; Region: PRK07908
767029003286	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
767029003287	pyridoxal 5'-phosphate binding site [chemical binding]; other site
767029003288	homodimer interface [polypeptide binding]; other site
767029003289	catalytic residue [active]
767029003290	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
767029003291	active site
767029003292	SAM binding site [chemical binding]; other site
767029003293	homodimer interface [polypeptide binding]; other site
767029003294	EXLDI protein; Region: EXLDI; TIGR04342
767029003295	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
767029003296	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
767029003297	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
767029003298	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
767029003299	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
767029003300	Predicted acetyltransferase [General function prediction only]; Region: COG3393
767029003301	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
767029003302	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
767029003303	prolyl-tRNA synthetase; Provisional; Region: PRK09194
767029003304	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
767029003305	dimer interface [polypeptide binding]; other site
767029003306	motif 1; other site
767029003307	active site
767029003308	motif 2; other site
767029003309	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
767029003310	putative deacylase active site [active]
767029003311	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
767029003312	active site
767029003313	motif 3; other site
767029003314	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
767029003315	anticodon binding site; other site
767029003316	ribosome maturation protein RimP; Reviewed; Region: PRK00092
767029003317	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
767029003318	putative oligomer interface [polypeptide binding]; other site
767029003319	putative RNA binding site [nucleotide binding]; other site
767029003320	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
767029003321	NusA N-terminal domain; Region: NusA_N; pfam08529
767029003322	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
767029003323	RNA binding site [nucleotide binding]; other site
767029003324	homodimer interface [polypeptide binding]; other site
767029003325	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
767029003326	G-X-X-G motif; other site
767029003327	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
767029003328	G-X-X-G motif; other site
767029003329	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189
767029003330	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
767029003331	translation initiation factor IF-2; Region: IF-2; TIGR00487
767029003332	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
767029003333	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
767029003334	G1 box; other site
767029003335	putative GEF interaction site [polypeptide binding]; other site
767029003336	GTP/Mg2+ binding site [chemical binding]; other site
767029003337	Switch I region; other site
767029003338	G2 box; other site
767029003339	G3 box; other site
767029003340	Switch II region; other site
767029003341	G4 box; other site
767029003342	G5 box; other site
767029003343	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
767029003344	Translation-initiation factor 2; Region: IF-2; pfam11987
767029003345	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
767029003346	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
767029003347	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
767029003348	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
767029003349	RNA binding site [nucleotide binding]; other site
767029003350	active site
767029003351	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
767029003352	Transcriptional regulators [Transcription]; Region: FadR; COG2186
767029003353	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
767029003354	DNA-binding site [nucleotide binding]; DNA binding site
767029003355	FCD domain; Region: FCD; pfam07729
767029003356	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
767029003357	dimer interface [polypeptide binding]; other site
767029003358	putative PBP binding regions; other site
767029003359	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
767029003360	ABC-ATPase subunit  interface; other site
767029003361	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
767029003362	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
767029003363	intersubunit interface [polypeptide binding]; other site
767029003364	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
767029003365	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
767029003366	intersubunit interface [polypeptide binding]; other site
767029003367	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
767029003368	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
767029003369	Walker A/P-loop; other site
767029003370	ATP binding site [chemical binding]; other site
767029003371	Q-loop/lid; other site
767029003372	ABC transporter signature motif; other site
767029003373	Walker B; other site
767029003374	D-loop; other site
767029003375	H-loop/switch region; other site
767029003376	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
767029003377	S-adenosylmethionine binding site [chemical binding]; other site
767029003378	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
767029003379	L-lactate permease; Region: Lactate_perm; cl00701
767029003380	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
767029003381	Cysteine-rich domain; Region: CCG; pfam02754
767029003382	Cysteine-rich domain; Region: CCG; pfam02754
767029003383	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
767029003384	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
767029003385	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
767029003386	Uncharacterized conserved protein [Function unknown]; Region: COG1556
767029003387	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
767029003388	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
767029003389	active site
767029003390	Riboflavin kinase; Region: Flavokinase; smart00904
767029003391	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
767029003392	16S/18S rRNA binding site [nucleotide binding]; other site
767029003393	S13e-L30e interaction site [polypeptide binding]; other site
767029003394	25S rRNA binding site [nucleotide binding]; other site
767029003395	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
767029003396	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
767029003397	oligomer interface [polypeptide binding]; other site
767029003398	RNA binding site [nucleotide binding]; other site
767029003399	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
767029003400	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
767029003401	RNase E interface [polypeptide binding]; other site
767029003402	trimer interface [polypeptide binding]; other site
767029003403	active site
767029003404	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
767029003405	putative nucleic acid binding region [nucleotide binding]; other site
767029003406	G-X-X-G motif; other site
767029003407	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
767029003408	RNA binding site [nucleotide binding]; other site
767029003409	domain interface; other site
767029003410	dihydrodipicolinate reductase; Provisional; Region: PRK00048
767029003411	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
767029003412	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
767029003413	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
767029003414	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
767029003415	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
767029003416	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
767029003417	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
767029003418	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
767029003419	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
767029003420	ssDNA binding site; other site
767029003421	generic binding surface II; other site
767029003422	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
767029003423	ATP binding site [chemical binding]; other site
767029003424	putative Mg++ binding site [ion binding]; other site
767029003425	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
767029003426	nucleotide binding region [chemical binding]; other site
767029003427	ATP-binding site [chemical binding]; other site
767029003428	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
767029003429	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
767029003430	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
767029003431	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
767029003432	active site
767029003433	(T/H)XGH motif; other site
767029003434	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
767029003435	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
767029003436	Walker A/P-loop; other site
767029003437	ATP binding site [chemical binding]; other site
767029003438	Q-loop/lid; other site
767029003439	ABC transporter signature motif; other site
767029003440	Walker B; other site
767029003441	D-loop; other site
767029003442	H-loop/switch region; other site
767029003443	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
767029003444	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
767029003445	Walker A/P-loop; other site
767029003446	ATP binding site [chemical binding]; other site
767029003447	Q-loop/lid; other site
767029003448	ABC transporter signature motif; other site
767029003449	Walker B; other site
767029003450	D-loop; other site
767029003451	H-loop/switch region; other site
767029003452	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
767029003453	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029003454	dimer interface [polypeptide binding]; other site
767029003455	conserved gate region; other site
767029003456	putative PBP binding loops; other site
767029003457	ABC-ATPase subunit interface; other site
767029003458	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
767029003459	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029003460	dimer interface [polypeptide binding]; other site
767029003461	conserved gate region; other site
767029003462	putative PBP binding loops; other site
767029003463	ABC-ATPase subunit interface; other site
767029003464	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
767029003465	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
767029003466	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
767029003467	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
767029003468	DTAP/Switch II; other site
767029003469	Switch I; other site
767029003470	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
767029003471	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
767029003472	P loop; other site
767029003473	Nucleotide binding site [chemical binding]; other site
767029003474	DTAP/Switch II; other site
767029003475	Switch I; other site
767029003476	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
767029003477	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
767029003478	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
767029003479	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
767029003480	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
767029003481	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
767029003482	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
767029003483	dimerization interface [polypeptide binding]; other site
767029003484	active site
767029003485	metal binding site [ion binding]; metal-binding site
767029003486	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
767029003487	dsRNA binding site [nucleotide binding]; other site
767029003488	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
767029003489	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
767029003490	DNA binding site [nucleotide binding]
767029003491	catalytic residue [active]
767029003492	H2TH interface [polypeptide binding]; other site
767029003493	putative catalytic residues [active]
767029003494	turnover-facilitating residue; other site
767029003495	intercalation triad [nucleotide binding]; other site
767029003496	8OG recognition residue [nucleotide binding]; other site
767029003497	putative reading head residues; other site
767029003498	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
767029003499	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
767029003500	GtrA-like protein; Region: GtrA; pfam04138
767029003501	Predicted membrane protein [Function unknown]; Region: COG2246
767029003502	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
767029003503	AAA domain; Region: AAA_23; pfam13476
767029003504	Walker A/P-loop; other site
767029003505	ATP binding site [chemical binding]; other site
767029003506	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
767029003507	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
767029003508	ABC transporter signature motif; other site
767029003509	Walker B; other site
767029003510	D-loop; other site
767029003511	H-loop/switch region; other site
767029003512	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
767029003513	dimerization interface [polypeptide binding]; other site
767029003514	putative DNA binding site [nucleotide binding]; other site
767029003515	putative Zn2+ binding site [ion binding]; other site
767029003516	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
767029003517	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
767029003518	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
767029003519	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029003520	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029003521	active site
767029003522	phosphorylation site [posttranslational modification]
767029003523	intermolecular recognition site; other site
767029003524	dimerization interface [polypeptide binding]; other site
767029003525	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029003526	DNA binding residues [nucleotide binding]
767029003527	dimerization interface [polypeptide binding]; other site
767029003528	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
767029003529	Histidine kinase; Region: HisKA_3; pfam07730
767029003530	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
767029003531	signal recognition particle protein; Provisional; Region: PRK10867
767029003532	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
767029003533	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
767029003534	P loop; other site
767029003535	GTP binding site [chemical binding]; other site
767029003536	Signal peptide binding domain; Region: SRP_SPB; pfam02978
767029003537	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
767029003538	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
767029003539	active site
767029003540	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
767029003541	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
767029003542	tandem repeat interface [polypeptide binding]; other site
767029003543	oligomer interface [polypeptide binding]; other site
767029003544	active site residues [active]
767029003545	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
767029003546	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
767029003547	hypothetical protein; Provisional; Region: PRK02821
767029003548	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
767029003549	16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273
767029003550	RimM N-terminal domain; Region: RimM; pfam01782
767029003551	PRC-barrel domain; Region: PRC; pfam05239
767029003552	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
767029003553	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
767029003554	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
767029003555	putative Iron-sulfur protein interface [polypeptide binding]; other site
767029003556	proximal heme binding site [chemical binding]; other site
767029003557	distal heme binding site [chemical binding]; other site
767029003558	putative dimer interface [polypeptide binding]; other site
767029003559	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
767029003560	L-aspartate oxidase; Provisional; Region: PRK06175
767029003561	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
767029003562	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
767029003563	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
767029003564	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
767029003565	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
767029003566	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
767029003567	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
767029003568	Catalytic site [active]
767029003569	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
767029003570	RNA/DNA hybrid binding site [nucleotide binding]; other site
767029003571	active site
767029003572	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
767029003573	hypothetical protein; Reviewed; Region: PRK12497
767029003574	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
767029003575	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
767029003576	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
767029003577	Walker A motif; other site
767029003578	ATP binding site [chemical binding]; other site
767029003579	Walker B motif; other site
767029003580	arginine finger; other site
767029003581	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
767029003582	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
767029003583	DNA protecting protein DprA; Region: dprA; TIGR00732
767029003584	PQQ-like domain; Region: PQQ_2; pfam13360
767029003585	YWTD domain; Region: YWTD; cl17223
767029003586	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
767029003587	PQQ-like domain; Region: PQQ_2; pfam13360
767029003588	Bacterial SH3 domain; Region: SH3_3; pfam08239
767029003589	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
767029003590	Bacterial SH3 domain; Region: SH3_3; pfam08239
767029003591	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
767029003592	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
767029003593	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
767029003594	PYR/PP interface [polypeptide binding]; other site
767029003595	dimer interface [polypeptide binding]; other site
767029003596	TPP binding site [chemical binding]; other site
767029003597	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
767029003598	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
767029003599	TPP-binding site [chemical binding]; other site
767029003600	dimer interface [polypeptide binding]; other site
767029003601	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
767029003602	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
767029003603	putative valine binding site [chemical binding]; other site
767029003604	dimer interface [polypeptide binding]; other site
767029003605	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
767029003606	ketol-acid reductoisomerase; Provisional; Region: PRK05479
767029003607	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
767029003608	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
767029003609	benzoate transport; Region: 2A0115; TIGR00895
767029003610	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029003611	putative substrate translocation pore; other site
767029003612	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029003613	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
767029003614	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
767029003615	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
767029003616	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
767029003617	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
767029003618	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
767029003619	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
767029003620	L-asparaginase II; Region: Asparaginase_II; pfam06089
767029003621	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029003622	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029003623	active site
767029003624	phosphorylation site [posttranslational modification]
767029003625	intermolecular recognition site; other site
767029003626	dimerization interface [polypeptide binding]; other site
767029003627	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029003628	DNA binding residues [nucleotide binding]
767029003629	dimerization interface [polypeptide binding]; other site
767029003630	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
767029003631	Histidine kinase; Region: HisKA_3; pfam07730
767029003632	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
767029003633	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029003634	Walker A/P-loop; other site
767029003635	ATP binding site [chemical binding]; other site
767029003636	Q-loop/lid; other site
767029003637	ABC transporter signature motif; other site
767029003638	Walker B; other site
767029003639	D-loop; other site
767029003640	H-loop/switch region; other site
767029003641	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
767029003642	Transcriptional regulator [Transcription]; Region: IclR; COG1414
767029003643	Bacterial transcriptional regulator; Region: IclR; pfam01614
767029003644	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
767029003645	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
767029003646	substrate binding site [chemical binding]; other site
767029003647	ligand binding site [chemical binding]; other site
767029003648	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
767029003649	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
767029003650	substrate binding site [chemical binding]; other site
767029003651	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
767029003652	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
767029003653	putative acyl-acceptor binding pocket; other site
767029003654	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
767029003655	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
767029003656	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
767029003657	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
767029003658	ABC-ATPase subunit  interface; other site
767029003659	dimer interface [polypeptide binding]; other site
767029003660	putative PBP binding regions; other site
767029003661	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
767029003662	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
767029003663	Walker A/P-loop; other site
767029003664	ATP binding site [chemical binding]; other site
767029003665	Q-loop/lid; other site
767029003666	ABC transporter signature motif; other site
767029003667	Walker B; other site
767029003668	D-loop; other site
767029003669	H-loop/switch region; other site
767029003670	Domain of unknown function (DUF4213); Region: DUF4213; pfam13938
767029003671	Domain of unknown function (DUF364); Region: DUF364; pfam04016
767029003672	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
767029003673	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
767029003674	intersubunit interface [polypeptide binding]; other site
767029003675	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
767029003676	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
767029003677	ATP-grasp domain; Region: ATP-grasp_4; cl17255
767029003678	thiamine monophosphate kinase; Provisional; Region: PRK05731
767029003679	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
767029003680	ATP binding site [chemical binding]; other site
767029003681	dimerization interface [polypeptide binding]; other site
767029003682	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
767029003683	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
767029003684	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
767029003685	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
767029003686	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
767029003687	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
767029003688	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
767029003689	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
767029003690	FeS/SAM binding site; other site
767029003691	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
767029003692	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
767029003693	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
767029003694	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
767029003695	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
767029003696	recombinase A; Provisional; Region: recA; PRK09354
767029003697	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
767029003698	hexamer interface [polypeptide binding]; other site
767029003699	Walker A motif; other site
767029003700	ATP binding site [chemical binding]; other site
767029003701	Walker B motif; other site
767029003702	recombination regulator RecX; Reviewed; Region: recX; PRK00117
767029003703	phosphodiesterase; Provisional; Region: PRK12704
767029003704	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
767029003705	Zn2+ binding site [ion binding]; other site
767029003706	Mg2+ binding site [ion binding]; other site
767029003707	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
767029003708	active site
767029003709	catalytic residues [active]
767029003710	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
767029003711	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
767029003712	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
767029003713	FeS/SAM binding site; other site
767029003714	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
767029003715	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
767029003716	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
767029003717	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
767029003718	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
767029003719	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
767029003720	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
767029003721	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
767029003722	HflX GTPase family; Region: HflX; cd01878
767029003723	G1 box; other site
767029003724	GTP/Mg2+ binding site [chemical binding]; other site
767029003725	Switch I region; other site
767029003726	G2 box; other site
767029003727	G3 box; other site
767029003728	Switch II region; other site
767029003729	G4 box; other site
767029003730	G5 box; other site
767029003731	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
767029003732	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
767029003733	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
767029003734	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
767029003735	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
767029003736	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
767029003737	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029003738	dimer interface [polypeptide binding]; other site
767029003739	conserved gate region; other site
767029003740	putative PBP binding loops; other site
767029003741	ABC-ATPase subunit interface; other site
767029003742	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
767029003743	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029003744	dimer interface [polypeptide binding]; other site
767029003745	conserved gate region; other site
767029003746	putative PBP binding loops; other site
767029003747	ABC-ATPase subunit interface; other site
767029003748	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
767029003749	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
767029003750	ligand binding site [chemical binding]; other site
767029003751	NAD binding site [chemical binding]; other site
767029003752	tetramer interface [polypeptide binding]; other site
767029003753	catalytic site [active]
767029003754	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
767029003755	L-serine binding site [chemical binding]; other site
767029003756	ACT domain interface; other site
767029003757	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
767029003758	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
767029003759	active site
767029003760	Predicted GTPases [General function prediction only]; Region: COG1162
767029003761	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
767029003762	GTPase/Zn-binding domain interface [polypeptide binding]; other site
767029003763	GTP/Mg2+ binding site [chemical binding]; other site
767029003764	G4 box; other site
767029003765	G1 box; other site
767029003766	Switch I region; other site
767029003767	G2 box; other site
767029003768	G3 box; other site
767029003769	Switch II region; other site
767029003770	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
767029003771	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
767029003772	hinge; other site
767029003773	active site
767029003774	HR-like lesion-inducing; Region: HR_lesion; pfam05514
767029003775	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
767029003776	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
767029003777	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
767029003778	DNA binding residues [nucleotide binding]
767029003779	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
767029003780	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
767029003781	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
767029003782	Histidine kinase; Region: HisKA_2; pfam07568
767029003783	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029003784	ATP binding site [chemical binding]; other site
767029003785	Mg2+ binding site [ion binding]; other site
767029003786	G-X-G motif; other site
767029003787	Transcription factor WhiB; Region: Whib; pfam02467
767029003788	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
767029003789	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
767029003790	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
767029003791	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
767029003792	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
767029003793	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
767029003794	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
767029003795	TPP-binding site [chemical binding]; other site
767029003796	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
767029003797	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
767029003798	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
767029003799	diaminopimelate decarboxylase; Region: lysA; TIGR01048
767029003800	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
767029003801	active site
767029003802	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
767029003803	substrate binding site [chemical binding]; other site
767029003804	catalytic residues [active]
767029003805	dimer interface [polypeptide binding]; other site
767029003806	homoserine dehydrogenase; Provisional; Region: PRK06349
767029003807	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
767029003808	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
767029003809	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
767029003810	homoserine kinase; Provisional; Region: PRK01212
767029003811	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
767029003812	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
767029003813	peptide chain release factor 1; Validated; Region: prfA; PRK00591
767029003814	This domain is found in peptide chain release factors; Region: PCRF; smart00937
767029003815	RF-1 domain; Region: RF-1; pfam00472
767029003816	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
767029003817	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
767029003818	S-adenosylmethionine binding site [chemical binding]; other site
767029003819	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
767029003820	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
767029003821	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
767029003822	Mg++ binding site [ion binding]; other site
767029003823	putative catalytic motif [active]
767029003824	substrate binding site [chemical binding]; other site
767029003825	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
767029003826	ATP synthase subunit C; Region: ATP-synt_C; cl00466
767029003827	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
767029003828	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
767029003829	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
767029003830	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
767029003831	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
767029003832	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
767029003833	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
767029003834	beta subunit interaction interface [polypeptide binding]; other site
767029003835	Walker A motif; other site
767029003836	ATP binding site [chemical binding]; other site
767029003837	Walker B motif; other site
767029003838	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
767029003839	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
767029003840	core domain interface [polypeptide binding]; other site
767029003841	delta subunit interface [polypeptide binding]; other site
767029003842	epsilon subunit interface [polypeptide binding]; other site
767029003843	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
767029003844	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
767029003845	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
767029003846	alpha subunit interaction interface [polypeptide binding]; other site
767029003847	Walker A motif; other site
767029003848	ATP binding site [chemical binding]; other site
767029003849	Walker B motif; other site
767029003850	inhibitor binding site; inhibition site
767029003851	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
767029003852	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
767029003853	gamma subunit interface [polypeptide binding]; other site
767029003854	epsilon subunit interface [polypeptide binding]; other site
767029003855	LBP interface [polypeptide binding]; other site
767029003856	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
767029003857	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
767029003858	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
767029003859	active site
767029003860	acyl-CoA esterase; Provisional; Region: PRK10673
767029003861	PGAP1-like protein; Region: PGAP1; pfam07819
767029003862	hypothetical protein; Provisional; Region: PRK03298
767029003863	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
767029003864	Domain of unknown function DUF20; Region: UPF0118; pfam01594
767029003865	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
767029003866	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
767029003867	dimer interface [polypeptide binding]; other site
767029003868	substrate binding site [chemical binding]; other site
767029003869	metal binding site [ion binding]; metal-binding site
767029003870	Bacterial PH domain; Region: DUF304; pfam03703
767029003871	phosphoglucomutase; Validated; Region: PRK07564
767029003872	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
767029003873	active site
767029003874	substrate binding site [chemical binding]; other site
767029003875	metal binding site [ion binding]; metal-binding site
767029003876	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
767029003877	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
767029003878	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
767029003879	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
767029003880	catalytic residue [active]
767029003881	putative FPP diphosphate  binding site; other site
767029003882	putative FPP binding hydrophobic cleft; other site
767029003883	dimer interface [polypeptide binding]; other site
767029003884	putative IPP diphosphate binding site; other site
767029003885	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
767029003886	Recombination protein O N terminal; Region: RecO_N; pfam11967
767029003887	Recombination protein O C terminal; Region: RecO_C; pfam02565
767029003888	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
767029003889	metal binding site 2 [ion binding]; metal-binding site
767029003890	putative DNA binding helix; other site
767029003891	metal binding site 1 [ion binding]; metal-binding site
767029003892	dimer interface [polypeptide binding]; other site
767029003893	structural Zn2+ binding site [ion binding]; other site
767029003894	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
767029003895	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
767029003896	ABC-ATPase subunit  interface; other site
767029003897	dimer interface [polypeptide binding]; other site
767029003898	putative PBP binding regions; other site
767029003899	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
767029003900	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
767029003901	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
767029003902	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
767029003903	intersubunit interface [polypeptide binding]; other site
767029003904	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
767029003905	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
767029003906	Melibiase; Region: Melibiase; pfam02065
767029003907	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029003908	dimer interface [polypeptide binding]; other site
767029003909	conserved gate region; other site
767029003910	putative PBP binding loops; other site
767029003911	ABC-ATPase subunit interface; other site
767029003912	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
767029003913	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029003914	dimer interface [polypeptide binding]; other site
767029003915	conserved gate region; other site
767029003916	putative PBP binding loops; other site
767029003917	ABC-ATPase subunit interface; other site
767029003918	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
767029003919	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
767029003920	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
767029003921	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
767029003922	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
767029003923	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
767029003924	active site
767029003925	Zn binding site [ion binding]; other site
767029003926	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
767029003927	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
767029003928	FMN binding site [chemical binding]; other site
767029003929	active site
767029003930	catalytic residues [active]
767029003931	substrate binding site [chemical binding]; other site
767029003932	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
767029003933	dimer interface [polypeptide binding]; other site
767029003934	Citrate synthase; Region: Citrate_synt; pfam00285
767029003935	active site
767029003936	citrylCoA binding site [chemical binding]; other site
767029003937	NADH binding [chemical binding]; other site
767029003938	cationic pore residues; other site
767029003939	oxalacetate/citrate binding site [chemical binding]; other site
767029003940	coenzyme A binding site [chemical binding]; other site
767029003941	catalytic triad [active]
767029003942	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
767029003943	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
767029003944	Walker A/P-loop; other site
767029003945	ATP binding site [chemical binding]; other site
767029003946	Q-loop/lid; other site
767029003947	ABC transporter signature motif; other site
767029003948	Walker B; other site
767029003949	D-loop; other site
767029003950	H-loop/switch region; other site
767029003951	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
767029003952	Histidine kinase; Region: HisKA_3; pfam07730
767029003953	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029003954	ATP binding site [chemical binding]; other site
767029003955	Mg2+ binding site [ion binding]; other site
767029003956	G-X-G motif; other site
767029003957	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029003958	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029003959	active site
767029003960	phosphorylation site [posttranslational modification]
767029003961	intermolecular recognition site; other site
767029003962	dimerization interface [polypeptide binding]; other site
767029003963	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029003964	DNA binding residues [nucleotide binding]
767029003965	dimerization interface [polypeptide binding]; other site
767029003966	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
767029003967	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
767029003968	Zn2+ binding site [ion binding]; other site
767029003969	Mg2+ binding site [ion binding]; other site
767029003970	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
767029003971	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
767029003972	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
767029003973	Walker A/P-loop; other site
767029003974	ATP binding site [chemical binding]; other site
767029003975	Q-loop/lid; other site
767029003976	ABC transporter signature motif; other site
767029003977	Walker B; other site
767029003978	D-loop; other site
767029003979	H-loop/switch region; other site
767029003980	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
767029003981	Histidine kinase; Region: HisKA_3; pfam07730
767029003982	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029003983	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029003984	active site
767029003985	phosphorylation site [posttranslational modification]
767029003986	intermolecular recognition site; other site
767029003987	dimerization interface [polypeptide binding]; other site
767029003988	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029003989	DNA binding residues [nucleotide binding]
767029003990	dimerization interface [polypeptide binding]; other site
767029003991	DNA primase; Validated; Region: dnaG; PRK05667
767029003992	CHC2 zinc finger; Region: zf-CHC2; cl17510
767029003993	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
767029003994	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
767029003995	active site
767029003996	metal binding site [ion binding]; metal-binding site
767029003997	interdomain interaction site; other site
767029003998	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879
767029003999	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
767029004000	catalytic core [active]
767029004001	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
767029004002	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
767029004003	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
767029004004	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029004005	dimer interface [polypeptide binding]; other site
767029004006	conserved gate region; other site
767029004007	putative PBP binding loops; other site
767029004008	ABC-ATPase subunit interface; other site
767029004009	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
767029004010	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029004011	dimer interface [polypeptide binding]; other site
767029004012	conserved gate region; other site
767029004013	putative PBP binding loops; other site
767029004014	ABC-ATPase subunit interface; other site
767029004015	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
767029004016	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
767029004017	Walker A/P-loop; other site
767029004018	ATP binding site [chemical binding]; other site
767029004019	Q-loop/lid; other site
767029004020	ABC transporter signature motif; other site
767029004021	Walker B; other site
767029004022	D-loop; other site
767029004023	H-loop/switch region; other site
767029004024	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
767029004025	NADH(P)-binding; Region: NAD_binding_10; pfam13460
767029004026	NAD(P) binding site [chemical binding]; other site
767029004027	putative active site [active]
767029004028	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
767029004029	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
767029004030	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
767029004031	Ligand binding site; other site
767029004032	Putative Catalytic site; other site
767029004033	DXD motif; other site
767029004034	GtrA-like protein; Region: GtrA; pfam04138
767029004035	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
767029004036	glycyl-tRNA synthetase; Provisional; Region: PRK14908
767029004037	glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348
767029004038	motif 1; other site
767029004039	dimer interface [polypeptide binding]; other site
767029004040	active site
767029004041	motif 2; other site
767029004042	motif 3; other site
767029004043	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
767029004044	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
767029004045	active site
767029004046	motif I; other site
767029004047	motif II; other site
767029004048	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
767029004049	putative metal binding residues [ion binding]; other site
767029004050	signature motif; other site
767029004051	dimer interface [polypeptide binding]; other site
767029004052	active site
767029004053	polyP binding site; other site
767029004054	substrate binding site [chemical binding]; other site
767029004055	acceptor-phosphate pocket; other site
767029004056	MoxR-like ATPases [General function prediction only]; Region: COG0714
767029004057	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
767029004058	Walker A motif; other site
767029004059	ATP binding site [chemical binding]; other site
767029004060	arginine finger; other site
767029004061	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
767029004062	Protein of unknown function DUF58; Region: DUF58; pfam01882
767029004063	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
767029004064	von Willebrand factor type A domain; Region: VWA_2; pfam13519
767029004065	metal ion-dependent adhesion site (MIDAS); other site
767029004066	hypothetical protein; Provisional; Region: PRK13685
767029004067	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
767029004068	metal ion-dependent adhesion site (MIDAS); other site
767029004069	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
767029004070	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
767029004071	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
767029004072	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
767029004073	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
767029004074	dimer interface [polypeptide binding]; other site
767029004075	active site
767029004076	acyl carrier protein; Provisional; Region: acpP; PRK00982
767029004077	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
767029004078	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
767029004079	dimer interface [polypeptide binding]; other site
767029004080	active site
767029004081	CoA binding pocket [chemical binding]; other site
767029004082	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
767029004083	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
767029004084	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
767029004085	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
767029004086	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
767029004087	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
767029004088	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
767029004089	dimer interface [polypeptide binding]; other site
767029004090	TPP-binding site [chemical binding]; other site
767029004091	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
767029004092	6-phosphofructokinase, eukaryotic type; Region: 6PF1K_euk; TIGR02478
767029004093	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
767029004094	active site
767029004095	ADP/pyrophosphate binding site [chemical binding]; other site
767029004096	dimerization interface [polypeptide binding]; other site
767029004097	allosteric effector site; other site
767029004098	fructose-1,6-bisphosphate binding site; other site
767029004099	Yqey-like protein; Region: YqeY; cl17540
767029004100	peptide chain release factor 2; Validated; Region: prfB; PRK00578
767029004101	This domain is found in peptide chain release factors; Region: PCRF; smart00937
767029004102	RF-1 domain; Region: RF-1; pfam00472
767029004103	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
767029004104	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029004105	Walker A/P-loop; other site
767029004106	ATP binding site [chemical binding]; other site
767029004107	Q-loop/lid; other site
767029004108	ABC transporter signature motif; other site
767029004109	Walker B; other site
767029004110	D-loop; other site
767029004111	H-loop/switch region; other site
767029004112	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
767029004113	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
767029004114	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
767029004115	Peptidase family M23; Region: Peptidase_M23; pfam01551
767029004116	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
767029004117	SmpB-tmRNA interface; other site
767029004118	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354
767029004119	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
767029004120	active site
767029004121	catalytic site [active]
767029004122	hypothetical protein; Validated; Region: PRK00228
767029004123	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
767029004124	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029004125	active site
767029004126	phosphorylation site [posttranslational modification]
767029004127	intermolecular recognition site; other site
767029004128	dimerization interface [polypeptide binding]; other site
767029004129	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
767029004130	DNA binding site [nucleotide binding]
767029004131	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
767029004132	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
767029004133	dimerization interface [polypeptide binding]; other site
767029004134	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
767029004135	dimer interface [polypeptide binding]; other site
767029004136	phosphorylation site [posttranslational modification]
767029004137	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029004138	ATP binding site [chemical binding]; other site
767029004139	Mg2+ binding site [ion binding]; other site
767029004140	G-X-G motif; other site
767029004141	lipoprotein LpqB; Provisional; Region: PRK13613
767029004142	Sporulation and spore germination; Region: Germane; pfam10646
767029004143	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
767029004144	active site
767029004145	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
767029004146	30S subunit binding site; other site
767029004147	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
767029004148	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
767029004149	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
767029004150	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
767029004151	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
767029004152	active site
767029004153	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
767029004154	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
767029004155	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
767029004156	active site
767029004157	HIGH motif; other site
767029004158	dimer interface [polypeptide binding]; other site
767029004159	KMSKS motif; other site
767029004160	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
767029004161	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
767029004162	putative Mg++ binding site [ion binding]; other site
767029004163	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
767029004164	nucleotide binding region [chemical binding]; other site
767029004165	ATP-binding site [chemical binding]; other site
767029004166	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
767029004167	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
767029004168	active site
767029004169	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
767029004170	DNA-binding site [nucleotide binding]; DNA binding site
767029004171	RNA-binding motif; other site
767029004172	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
767029004173	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
767029004174	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
767029004175	Part of AAA domain; Region: AAA_19; pfam13245
767029004176	Family description; Region: UvrD_C_2; pfam13538
767029004177	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
767029004178	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
767029004179	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029004180	ATP binding site [chemical binding]; other site
767029004181	Mg2+ binding site [ion binding]; other site
767029004182	G-X-G motif; other site
767029004183	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
767029004184	anchoring element; other site
767029004185	dimer interface [polypeptide binding]; other site
767029004186	ATP binding site [chemical binding]; other site
767029004187	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
767029004188	active site
767029004189	metal binding site [ion binding]; metal-binding site
767029004190	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
767029004191	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
767029004192	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
767029004193	active site clefts [active]
767029004194	zinc binding site [ion binding]; other site
767029004195	dimer interface [polypeptide binding]; other site
767029004196	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
767029004197	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
767029004198	CAP-like domain; other site
767029004199	active site
767029004200	primary dimer interface [polypeptide binding]; other site
767029004201	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
767029004202	Uncharacterized conserved protein [Function unknown]; Region: COG4850
767029004203	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
767029004204	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
767029004205	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
767029004206	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
767029004207	thymidine kinase; Provisional; Region: PRK04296
767029004208	AAA domain; Region: AAA_14; pfam13173
767029004209	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
767029004210	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
767029004211	Protein of unknown function (DUF4235); Region: DUF4235; pfam14019
767029004212	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
767029004213	trimer interface [polypeptide binding]; other site
767029004214	active site
767029004215	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
767029004216	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
767029004217	ssDNA binding site; other site
767029004218	generic binding surface II; other site
767029004219	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
767029004220	TrkA-N domain; Region: TrkA_N; pfam02254
767029004221	TrkA-C domain; Region: TrkA_C; pfam02080
767029004222	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
767029004223	TrkA-N domain; Region: TrkA_N; pfam02254
767029004224	TrkA-C domain; Region: TrkA_C; pfam02080
767029004225	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
767029004226	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
767029004227	TRAM domain; Region: TRAM; pfam01938
767029004228	Methyltransferase domain; Region: Methyltransf_26; pfam13659
767029004229	S-adenosylmethionine binding site [chemical binding]; other site
767029004230	aconitate hydratase; Validated; Region: PRK09277
767029004231	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
767029004232	substrate binding site [chemical binding]; other site
767029004233	ligand binding site [chemical binding]; other site
767029004234	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
767029004235	substrate binding site [chemical binding]; other site
767029004236	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
767029004237	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
767029004238	hexamer interface [polypeptide binding]; other site
767029004239	ligand binding site [chemical binding]; other site
767029004240	putative active site [active]
767029004241	NAD(P) binding site [chemical binding]; other site
767029004242	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
767029004243	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
767029004244	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
767029004245	TPP-binding site; other site
767029004246	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
767029004247	PYR/PP interface [polypeptide binding]; other site
767029004248	dimer interface [polypeptide binding]; other site
767029004249	TPP binding site [chemical binding]; other site
767029004250	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
767029004251	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
767029004252	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
767029004253	catalytic site [active]
767029004254	putative active site [active]
767029004255	putative substrate binding site [chemical binding]; other site
767029004256	HRDC domain; Region: HRDC; pfam00570
767029004257	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
767029004258	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
767029004259	SelR domain; Region: SelR; pfam01641
767029004260	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
767029004261	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
767029004262	putative active site [active]
767029004263	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
767029004264	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
767029004265	tetramerization interface [polypeptide binding]; other site
767029004266	NAD(P) binding site [chemical binding]; other site
767029004267	catalytic residues [active]
767029004268	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
767029004269	Coenzyme A binding pocket [chemical binding]; other site
767029004270	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
767029004271	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
767029004272	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
767029004273	active site
767029004274	dimer interface [polypeptide binding]; other site
767029004275	motif 1; other site
767029004276	motif 2; other site
767029004277	motif 3; other site
767029004278	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
767029004279	anticodon binding site; other site
767029004280	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
767029004281	nucleotide binding site/active site [active]
767029004282	HIT family signature motif; other site
767029004283	catalytic residue [active]
767029004284	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
767029004285	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
767029004286	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
767029004287	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
767029004288	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
767029004289	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
767029004290	phosphopeptide binding site; other site
767029004291	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
767029004292	DNA binding residues [nucleotide binding]
767029004293	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
767029004294	Bifunctional nuclease; Region: DNase-RNase; cl00553
767029004295	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
767029004296	DNA binding residues [nucleotide binding]
767029004297	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
767029004298	putative dimer interface [polypeptide binding]; other site
767029004299	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
767029004300	pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555
767029004301	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
767029004302	active site
767029004303	ADP/pyrophosphate binding site [chemical binding]; other site
767029004304	allosteric effector site; other site
767029004305	dimerization interface [polypeptide binding]; other site
767029004306	fructose-1,6-bisphosphate binding site; other site
767029004307	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
767029004308	Amidohydrolase family; Region: Amidohydro_3; pfam07969
767029004309	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
767029004310	active site
767029004311	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
767029004312	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
767029004313	catalytic residue [active]
767029004314	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
767029004315	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
767029004316	putative homotetramer interface [polypeptide binding]; other site
767029004317	putative homodimer interface [polypeptide binding]; other site
767029004318	putative allosteric switch controlling residues; other site
767029004319	putative metal binding site [ion binding]; other site
767029004320	putative homodimer-homodimer interface [polypeptide binding]; other site
767029004321	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
767029004322	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
767029004323	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
767029004324	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
767029004325	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
767029004326	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
767029004327	non-specific DNA binding site [nucleotide binding]; other site
767029004328	salt bridge; other site
767029004329	sequence-specific DNA binding site [nucleotide binding]; other site
767029004330	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
767029004331	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
767029004332	putative active site [active]
767029004333	pyridoxamine kinase; Validated; Region: PRK05756
767029004334	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
767029004335	dimer interface [polypeptide binding]; other site
767029004336	pyridoxal binding site [chemical binding]; other site
767029004337	ATP binding site [chemical binding]; other site
767029004338	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
767029004339	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
767029004340	putative active site [active]
767029004341	catalytic site [active]
767029004342	putative metal binding site [ion binding]; other site
767029004343	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
767029004344	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
767029004345	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
767029004346	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
767029004347	Ligand binding site; other site
767029004348	Putative Catalytic site; other site
767029004349	DXD motif; other site
767029004350	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
767029004351	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
767029004352	putative active site [active]
767029004353	catalytic triad [active]
767029004354	putative dimer interface [polypeptide binding]; other site
767029004355	Methyltransferase domain; Region: Methyltransf_23; pfam13489
767029004356	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
767029004357	S-adenosylmethionine binding site [chemical binding]; other site
767029004358	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
767029004359	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
767029004360	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
767029004361	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
767029004362	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
767029004363	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
767029004364	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650
767029004365	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
767029004366	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
767029004367	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
767029004368	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
767029004369	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
767029004370	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
767029004371	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
767029004372	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
767029004373	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
767029004374	active site
767029004375	substrate binding site [chemical binding]; other site
767029004376	FMN binding site [chemical binding]; other site
767029004377	putative catalytic residues [active]
767029004378	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
767029004379	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
767029004380	NADP binding site [chemical binding]; other site
767029004381	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
767029004382	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
767029004383	active site residue [active]
767029004384	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
767029004385	active site residue [active]
767029004386	GTP-binding protein Der; Reviewed; Region: PRK03003
767029004387	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
767029004388	G1 box; other site
767029004389	GTP/Mg2+ binding site [chemical binding]; other site
767029004390	Switch I region; other site
767029004391	G2 box; other site
767029004392	Switch II region; other site
767029004393	G3 box; other site
767029004394	G4 box; other site
767029004395	G5 box; other site
767029004396	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
767029004397	G1 box; other site
767029004398	GTP/Mg2+ binding site [chemical binding]; other site
767029004399	Switch I region; other site
767029004400	G2 box; other site
767029004401	G3 box; other site
767029004402	Switch II region; other site
767029004403	G4 box; other site
767029004404	G5 box; other site
767029004405	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
767029004406	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029004407	Walker A/P-loop; other site
767029004408	ATP binding site [chemical binding]; other site
767029004409	Q-loop/lid; other site
767029004410	ABC transporter signature motif; other site
767029004411	Walker B; other site
767029004412	D-loop; other site
767029004413	H-loop/switch region; other site
767029004414	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
767029004415	cytidylate kinase; Provisional; Region: cmk; PRK00023
767029004416	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
767029004417	CMP-binding site; other site
767029004418	The sites determining sugar specificity; other site
767029004419	prephenate dehydrogenase; Validated; Region: PRK08507
767029004420	prephenate dehydrogenase; Validated; Region: PRK06545
767029004421	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116
767029004422	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
767029004423	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
767029004424	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
767029004425	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
767029004426	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
767029004427	substrate binding pocket [chemical binding]; other site
767029004428	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
767029004429	B12 binding site [chemical binding]; other site
767029004430	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
767029004431	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
767029004432	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
767029004433	putative NADH binding site [chemical binding]; other site
767029004434	putative active site [active]
767029004435	nudix motif; other site
767029004436	putative metal binding site [ion binding]; other site
767029004437	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
767029004438	active site
767029004439	catalytic site [active]
767029004440	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
767029004441	Cna protein B-type domain; Region: Cna_B; pfam05738
767029004442	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
767029004443	PAC2 family; Region: PAC2; pfam09754
767029004444	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
767029004445	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
767029004446	substrate binding site [chemical binding]; other site
767029004447	hexamer interface [polypeptide binding]; other site
767029004448	metal binding site [ion binding]; metal-binding site
767029004449	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
767029004450	16S rRNA methyltransferase B; Provisional; Region: PRK14902
767029004451	putative RNA binding site [nucleotide binding]; other site
767029004452	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
767029004453	S-adenosylmethionine binding site [chemical binding]; other site
767029004454	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
767029004455	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
767029004456	putative active site [active]
767029004457	substrate binding site [chemical binding]; other site
767029004458	putative cosubstrate binding site; other site
767029004459	catalytic site [active]
767029004460	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
767029004461	substrate binding site [chemical binding]; other site
767029004462	primosome assembly protein PriA; Provisional; Region: PRK14873
767029004463	S-adenosylmethionine synthetase; Validated; Region: PRK05250
767029004464	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
767029004465	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
767029004466	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
767029004467	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
767029004468	Guanylate kinase; Region: Guanylate_kin; pfam00625
767029004469	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
767029004470	catalytic site [active]
767029004471	G-X2-G-X-G-K; other site
767029004472	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
767029004473	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
767029004474	active site
767029004475	dimer interface [polypeptide binding]; other site
767029004476	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
767029004477	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
767029004478	quinone interaction residues [chemical binding]; other site
767029004479	active site
767029004480	catalytic residues [active]
767029004481	FMN binding site [chemical binding]; other site
767029004482	substrate binding site [chemical binding]; other site
767029004483	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
767029004484	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
767029004485	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
767029004486	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
767029004487	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
767029004488	ATP-grasp domain; Region: ATP-grasp_4; cl17255
767029004489	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
767029004490	IMP binding site; other site
767029004491	dimer interface [polypeptide binding]; other site
767029004492	interdomain contacts; other site
767029004493	partial ornithine binding site; other site
767029004494	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
767029004495	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
767029004496	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
767029004497	catalytic site [active]
767029004498	subunit interface [polypeptide binding]; other site
767029004499	transcription antitermination factor NusB; Region: nusB; TIGR01951
767029004500	putative RNA binding site [nucleotide binding]; other site
767029004501	elongation factor P; Validated; Region: PRK00529
767029004502	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
767029004503	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
767029004504	RNA binding site [nucleotide binding]; other site
767029004505	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
767029004506	RNA binding site [nucleotide binding]; other site
767029004507	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
767029004508	active site
767029004509	dimer interface [polypeptide binding]; other site
767029004510	metal binding site [ion binding]; metal-binding site
767029004511	shikimate kinase; Reviewed; Region: aroK; PRK00131
767029004512	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
767029004513	ADP binding site [chemical binding]; other site
767029004514	magnesium binding site [ion binding]; other site
767029004515	putative shikimate binding site; other site
767029004516	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
767029004517	chorismate synthase; Validated; Region: PRK05382
767029004518	Tetramer interface [polypeptide binding]; other site
767029004519	active site
767029004520	FMN-binding site [chemical binding]; other site
767029004521	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
767029004522	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
767029004523	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
767029004524	shikimate binding site; other site
767029004525	NAD(P) binding site [chemical binding]; other site
767029004526	YceG-like family; Region: YceG; pfam02618
767029004527	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
767029004528	dimerization interface [polypeptide binding]; other site
767029004529	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
767029004530	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
767029004531	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
767029004532	motif 1; other site
767029004533	active site
767029004534	motif 2; other site
767029004535	motif 3; other site
767029004536	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
767029004537	recombination factor protein RarA; Reviewed; Region: PRK13342
767029004538	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
767029004539	Walker A motif; other site
767029004540	ATP binding site [chemical binding]; other site
767029004541	Walker B motif; other site
767029004542	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
767029004543	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
767029004544	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029004545	putative substrate translocation pore; other site
767029004546	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
767029004547	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
767029004548	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
767029004549	dimer interface [polypeptide binding]; other site
767029004550	anticodon binding site; other site
767029004551	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
767029004552	homodimer interface [polypeptide binding]; other site
767029004553	motif 1; other site
767029004554	active site
767029004555	motif 2; other site
767029004556	GAD domain; Region: GAD; pfam02938
767029004557	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
767029004558	active site
767029004559	motif 3; other site
767029004560	histidyl-tRNA synthetase; Region: hisS; TIGR00442
767029004561	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
767029004562	dimer interface [polypeptide binding]; other site
767029004563	motif 1; other site
767029004564	active site
767029004565	motif 2; other site
767029004566	motif 3; other site
767029004567	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
767029004568	anticodon binding site; other site
767029004569	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
767029004570	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
767029004571	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
767029004572	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
767029004573	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
767029004574	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
767029004575	Zn2+ binding site [ion binding]; other site
767029004576	Mg2+ binding site [ion binding]; other site
767029004577	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
767029004578	synthetase active site [active]
767029004579	NTP binding site [chemical binding]; other site
767029004580	metal binding site [ion binding]; metal-binding site
767029004581	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
767029004582	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
767029004583	Ion channel; Region: Ion_trans_2; pfam07885
767029004584	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
767029004585	TrkA-N domain; Region: TrkA_N; pfam02254
767029004586	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
767029004587	active site
767029004588	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
767029004589	Protein export membrane protein; Region: SecD_SecF; pfam02355
767029004590	protein-export membrane protein SecD; Region: secD; TIGR01129
767029004591	Protein export membrane protein; Region: SecD_SecF; cl14618
767029004592	Preprotein translocase subunit; Region: YajC; pfam02699
767029004593	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
767029004594	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
767029004595	Walker A motif; other site
767029004596	ATP binding site [chemical binding]; other site
767029004597	Walker B motif; other site
767029004598	arginine finger; other site
767029004599	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
767029004600	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
767029004601	RuvA N terminal domain; Region: RuvA_N; pfam01330
767029004602	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
767029004603	active site
767029004604	putative DNA-binding cleft [nucleotide binding]; other site
767029004605	dimer interface [polypeptide binding]; other site
767029004606	hypothetical protein; Validated; Region: PRK00110
767029004607	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
767029004608	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
767029004609	Coenzyme A binding pocket [chemical binding]; other site
767029004610	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
767029004611	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
767029004612	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
767029004613	fatty acyl-CoA reductase; Region: PLN02996
767029004614	fatty acyl CoA reductases (FARs), extended (e) SDRs; Region: FAR-N_SDR_e; cd05236
767029004615	putative NAD(P) binding site [chemical binding]; other site
767029004616	active site
767029004617	putative substrate binding site [chemical binding]; other site
767029004618	C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071
767029004619	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
767029004620	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
767029004621	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
767029004622	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
767029004623	catalytic residues [active]
767029004624	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
767029004625	putative substrate binding pocket [chemical binding]; other site
767029004626	AC domain interface; other site
767029004627	catalytic triad [active]
767029004628	AB domain interface; other site
767029004629	NAD-dependent deacetylase; Provisional; Region: PRK00481
767029004630	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
767029004631	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
767029004632	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
767029004633	putative active site [active]
767029004634	oxyanion strand; other site
767029004635	catalytic triad [active]
767029004636	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
767029004637	putative active site pocket [active]
767029004638	4-fold oligomerization interface [polypeptide binding]; other site
767029004639	metal binding residues [ion binding]; metal-binding site
767029004640	3-fold/trimer interface [polypeptide binding]; other site
767029004641	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
767029004642	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
767029004643	pyridoxal 5'-phosphate binding site [chemical binding]; other site
767029004644	homodimer interface [polypeptide binding]; other site
767029004645	catalytic residue [active]
767029004646	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
767029004647	histidinol dehydrogenase; Region: hisD; TIGR00069
767029004648	NAD binding site [chemical binding]; other site
767029004649	dimerization interface [polypeptide binding]; other site
767029004650	product binding site; other site
767029004651	substrate binding site [chemical binding]; other site
767029004652	zinc binding site [ion binding]; other site
767029004653	catalytic residues [active]
767029004654	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
767029004655	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
767029004656	active site
767029004657	PHP Thumb interface [polypeptide binding]; other site
767029004658	metal binding site [ion binding]; metal-binding site
767029004659	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
767029004660	generic binding surface II; other site
767029004661	generic binding surface I; other site
767029004662	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
767029004663	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
767029004664	Putative sensor; Region: Sensor; pfam13796
767029004665	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
767029004666	Histidine kinase; Region: HisKA_3; pfam07730
767029004667	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029004668	ATP binding site [chemical binding]; other site
767029004669	Mg2+ binding site [ion binding]; other site
767029004670	G-X-G motif; other site
767029004671	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029004672	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029004673	active site
767029004674	phosphorylation site [posttranslational modification]
767029004675	intermolecular recognition site; other site
767029004676	dimerization interface [polypeptide binding]; other site
767029004677	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029004678	DNA binding residues [nucleotide binding]
767029004679	dimerization interface [polypeptide binding]; other site
767029004680	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
767029004681	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
767029004682	Walker A/P-loop; other site
767029004683	ATP binding site [chemical binding]; other site
767029004684	Q-loop/lid; other site
767029004685	ABC transporter signature motif; other site
767029004686	Walker B; other site
767029004687	D-loop; other site
767029004688	H-loop/switch region; other site
767029004689	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
767029004690	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029004691	Walker A/P-loop; other site
767029004692	ATP binding site [chemical binding]; other site
767029004693	Q-loop/lid; other site
767029004694	ABC transporter signature motif; other site
767029004695	Walker B; other site
767029004696	D-loop; other site
767029004697	H-loop/switch region; other site
767029004698	TOBE domain; Region: TOBE_2; pfam08402
767029004699	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
767029004700	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029004701	dimer interface [polypeptide binding]; other site
767029004702	conserved gate region; other site
767029004703	putative PBP binding loops; other site
767029004704	ABC-ATPase subunit interface; other site
767029004705	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
767029004706	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029004707	conserved gate region; other site
767029004708	dimer interface [polypeptide binding]; other site
767029004709	putative PBP binding loops; other site
767029004710	ABC-ATPase subunit interface; other site
767029004711	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
767029004712	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
767029004713	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
767029004714	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
767029004715	MarR family; Region: MarR_2; pfam12802
767029004716	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
767029004717	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
767029004718	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
767029004719	substrate binding site [chemical binding]; other site
767029004720	active site
767029004721	catalytic residues [active]
767029004722	heterodimer interface [polypeptide binding]; other site
767029004723	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
767029004724	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
767029004725	pyridoxal 5'-phosphate binding site [chemical binding]; other site
767029004726	catalytic residue [active]
767029004727	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
767029004728	active site
767029004729	ribulose/triose binding site [chemical binding]; other site
767029004730	phosphate binding site [ion binding]; other site
767029004731	substrate (anthranilate) binding pocket [chemical binding]; other site
767029004732	product (indole) binding pocket [chemical binding]; other site
767029004733	anthranilate synthase component I; Provisional; Region: PRK13571
767029004734	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
767029004735	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
767029004736	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
767029004737	Predicted transcriptional regulators [Transcription]; Region: COG1695
767029004738	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
767029004739	hypothetical protein; Reviewed; Region: PRK09588
767029004740	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
767029004741	TIGR03085 family protein; Region: TIGR03085
767029004742	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
767029004743	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
767029004744	GatB domain; Region: GatB_Yqey; smart00845
767029004745	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
767029004746	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
767029004747	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
767029004748	Transcriptional regulators [Transcription]; Region: FadR; COG2186
767029004749	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
767029004750	DNA-binding site [nucleotide binding]; DNA binding site
767029004751	FCD domain; Region: FCD; pfam07729
767029004752	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
767029004753	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029004754	Walker A/P-loop; other site
767029004755	ATP binding site [chemical binding]; other site
767029004756	Q-loop/lid; other site
767029004757	ABC transporter signature motif; other site
767029004758	Walker B; other site
767029004759	D-loop; other site
767029004760	H-loop/switch region; other site
767029004761	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
767029004762	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
767029004763	Histidine kinase; Region: HisKA_3; pfam07730
767029004764	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029004765	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029004766	active site
767029004767	phosphorylation site [posttranslational modification]
767029004768	intermolecular recognition site; other site
767029004769	dimerization interface [polypeptide binding]; other site
767029004770	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029004771	DNA binding residues [nucleotide binding]
767029004772	dimerization interface [polypeptide binding]; other site
767029004773	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
767029004774	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
767029004775	Walker A/P-loop; other site
767029004776	ATP binding site [chemical binding]; other site
767029004777	Q-loop/lid; other site
767029004778	ABC transporter signature motif; other site
767029004779	Walker B; other site
767029004780	D-loop; other site
767029004781	H-loop/switch region; other site
767029004782	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
767029004783	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
767029004784	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
767029004785	Ligand Binding Site [chemical binding]; other site
767029004786	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
767029004787	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
767029004788	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
767029004789	catalytic residue [active]
767029004790	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
767029004791	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
767029004792	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
767029004793	active site
767029004794	catalytic site [active]
767029004795	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
767029004796	putative homodimer interface [polypeptide binding]; other site
767029004797	putative active site pocket [active]
767029004798	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
767029004799	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
767029004800	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
767029004801	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
767029004802	active site
767029004803	catalytic site [active]
767029004804	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
767029004805	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
767029004806	glycogen branching enzyme; Provisional; Region: PRK12313
767029004807	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
767029004808	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
767029004809	active site
767029004810	catalytic site [active]
767029004811	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
767029004812	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
767029004813	nudix motif; other site
767029004814	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
767029004815	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
767029004816	intersubunit interface [polypeptide binding]; other site
767029004817	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
767029004818	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
767029004819	ABC-ATPase subunit  interface; other site
767029004820	dimer interface [polypeptide binding]; other site
767029004821	putative PBP binding regions; other site
767029004822	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
767029004823	ABC-ATPase subunit  interface; other site
767029004824	dimer interface [polypeptide binding]; other site
767029004825	putative PBP binding regions; other site
767029004826	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
767029004827	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
767029004828	Walker A/P-loop; other site
767029004829	ATP binding site [chemical binding]; other site
767029004830	Q-loop/lid; other site
767029004831	ABC transporter signature motif; other site
767029004832	Walker B; other site
767029004833	D-loop; other site
767029004834	H-loop/switch region; other site
767029004835	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
767029004836	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
767029004837	putative active site [active]
767029004838	putative metal binding site [ion binding]; other site
767029004839	2-isopropylmalate synthase; Validated; Region: PRK03739
767029004840	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
767029004841	active site
767029004842	catalytic residues [active]
767029004843	metal binding site [ion binding]; metal-binding site
767029004844	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
767029004845	GTPase Era; Reviewed; Region: era; PRK00089
767029004846	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
767029004847	G1 box; other site
767029004848	GTP/Mg2+ binding site [chemical binding]; other site
767029004849	Switch I region; other site
767029004850	G2 box; other site
767029004851	Switch II region; other site
767029004852	G3 box; other site
767029004853	G4 box; other site
767029004854	G5 box; other site
767029004855	KH domain; Region: KH_2; pfam07650
767029004856	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
767029004857	Domain of unknown function DUF21; Region: DUF21; pfam01595
767029004858	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
767029004859	Transporter associated domain; Region: CorC_HlyC; smart01091
767029004860	metal-binding heat shock protein; Provisional; Region: PRK00016
767029004861	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
767029004862	PhoH-like protein; Region: PhoH; pfam02562
767029004863	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
767029004864	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
767029004865	Transcriptional regulators [Transcription]; Region: PurR; COG1609
767029004866	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
767029004867	DNA binding site [nucleotide binding]
767029004868	domain linker motif; other site
767029004869	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
767029004870	dimerization interface [polypeptide binding]; other site
767029004871	ligand binding site [chemical binding]; other site
767029004872	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
767029004873	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
767029004874	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
767029004875	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
767029004876	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
767029004877	RNA methyltransferase, RsmE family; Region: TIGR00046
767029004878	chaperone protein DnaJ; Provisional; Region: PRK14278
767029004879	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
767029004880	HSP70 interaction site [polypeptide binding]; other site
767029004881	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
767029004882	Zn binding sites [ion binding]; other site
767029004883	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
767029004884	dimer interface [polypeptide binding]; other site
767029004885	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
767029004886	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
767029004887	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
767029004888	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
767029004889	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
767029004890	active site
767029004891	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
767029004892	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
767029004893	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
767029004894	Walker A/P-loop; other site
767029004895	ATP binding site [chemical binding]; other site
767029004896	Q-loop/lid; other site
767029004897	ABC transporter signature motif; other site
767029004898	Walker B; other site
767029004899	D-loop; other site
767029004900	H-loop/switch region; other site
767029004901	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
767029004902	DNA-binding site [nucleotide binding]; DNA binding site
767029004903	short chain dehydrogenase; Provisional; Region: PRK08219
767029004904	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
767029004905	NAD(P) binding site [chemical binding]; other site
767029004906	active site
767029004907	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
767029004908	SPFH domain / Band 7 family; Region: Band_7; pfam01145
767029004909	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
767029004910	nudix motif; other site
767029004911	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
767029004912	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
767029004913	Methyltransferase domain; Region: Methyltransf_31; pfam13847
767029004914	S-adenosylmethionine binding site [chemical binding]; other site
767029004915	Protein of unknown function (DUF664); Region: DUF664; pfam04978
767029004916	coproporphyrinogen III oxidase; Validated; Region: PRK05628
767029004917	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
767029004918	FeS/SAM binding site; other site
767029004919	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
767029004920	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
767029004921	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
767029004922	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
767029004923	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029004924	dimer interface [polypeptide binding]; other site
767029004925	putative PBP binding loops; other site
767029004926	ABC-ATPase subunit interface; other site
767029004927	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
767029004928	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029004929	dimer interface [polypeptide binding]; other site
767029004930	conserved gate region; other site
767029004931	putative PBP binding loops; other site
767029004932	ABC-ATPase subunit interface; other site
767029004933	Methyltransferase domain; Region: Methyltransf_31; pfam13847
767029004934	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
767029004935	S-adenosylmethionine binding site [chemical binding]; other site
767029004936	GTP-binding protein LepA; Provisional; Region: PRK05433
767029004937	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
767029004938	G1 box; other site
767029004939	putative GEF interaction site [polypeptide binding]; other site
767029004940	GTP/Mg2+ binding site [chemical binding]; other site
767029004941	Switch I region; other site
767029004942	G2 box; other site
767029004943	G3 box; other site
767029004944	Switch II region; other site
767029004945	G4 box; other site
767029004946	G5 box; other site
767029004947	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
767029004948	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
767029004949	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
767029004950	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
767029004951	hypothetical protein; Provisional; Region: PRK13663
767029004952	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
767029004953	hypothetical protein; Reviewed; Region: PRK07914
767029004954	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
767029004955	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
767029004956	Competence protein; Region: Competence; pfam03772
767029004957	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
767029004958	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
767029004959	SLBB domain; Region: SLBB; pfam10531
767029004960	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
767029004961	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
767029004962	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
767029004963	active site
767029004964	metal binding site [ion binding]; metal-binding site
767029004965	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
767029004966	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
767029004967	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
767029004968	Acyltransferase family; Region: Acyl_transf_3; pfam01757
767029004969	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
767029004970	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
767029004971	Histidine kinase; Region: HisKA_3; pfam07730
767029004972	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029004973	ATP binding site [chemical binding]; other site
767029004974	Mg2+ binding site [ion binding]; other site
767029004975	G-X-G motif; other site
767029004976	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029004977	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029004978	active site
767029004979	phosphorylation site [posttranslational modification]
767029004980	intermolecular recognition site; other site
767029004981	dimerization interface [polypeptide binding]; other site
767029004982	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029004983	DNA binding residues [nucleotide binding]
767029004984	dimerization interface [polypeptide binding]; other site
767029004985	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
767029004986	FAD binding domain; Region: FAD_binding_4; pfam01565
767029004987	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
767029004988	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
767029004989	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
767029004990	putative substrate binding site [chemical binding]; other site
767029004991	putative ATP binding site [chemical binding]; other site
767029004992	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
767029004993	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
767029004994	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
767029004995	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
767029004996	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
767029004997	Protein of unknown function DUF45; Region: DUF45; pfam01863
767029004998	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
767029004999	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029005000	AAA domain; Region: AAA_23; pfam13476
767029005001	Walker A/P-loop; other site
767029005002	ATP binding site [chemical binding]; other site
767029005003	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
767029005004	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
767029005005	active site
767029005006	metal binding site [ion binding]; metal-binding site
767029005007	DNA binding site [nucleotide binding]
767029005008	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
767029005009	dimerization interface [polypeptide binding]; other site
767029005010	putative DNA binding site [nucleotide binding]; other site
767029005011	putative Zn2+ binding site [ion binding]; other site
767029005012	H+ Antiporter protein; Region: 2A0121; TIGR00900
767029005013	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
767029005014	Methyltransferase domain; Region: Methyltransf_11; pfam08241
767029005015	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
767029005016	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
767029005017	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
767029005018	catalytic site [active]
767029005019	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029005020	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029005021	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
767029005022	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
767029005023	Walker A/P-loop; other site
767029005024	ATP binding site [chemical binding]; other site
767029005025	Q-loop/lid; other site
767029005026	ABC transporter signature motif; other site
767029005027	Walker B; other site
767029005028	D-loop; other site
767029005029	H-loop/switch region; other site
767029005030	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
767029005031	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
767029005032	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
767029005033	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
767029005034	Predicted membrane protein [Function unknown]; Region: COG2855
767029005035	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
767029005036	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
767029005037	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
767029005038	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
767029005039	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
767029005040	Coenzyme A binding pocket [chemical binding]; other site
767029005041	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
767029005042	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
767029005043	inhibitor-cofactor binding pocket; inhibition site
767029005044	pyridoxal 5'-phosphate binding site [chemical binding]; other site
767029005045	catalytic residue [active]
767029005046	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
767029005047	dimer interface [polypeptide binding]; other site
767029005048	active site
767029005049	Schiff base residues; other site
767029005050	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
767029005051	porphobilinogen deaminase; Provisional; Region: PRK01066
767029005052	domain interfaces; other site
767029005053	active site
767029005054	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
767029005055	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
767029005056	active site
767029005057	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
767029005058	hydroxyglutarate oxidase; Provisional; Region: PRK11728
767029005059	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
767029005060	substrate binding site [chemical binding]; other site
767029005061	active site
767029005062	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
767029005063	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
767029005064	NAD(P) binding pocket [chemical binding]; other site
767029005065	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
767029005066	ferrochelatase; Reviewed; Region: hemH; PRK00035
767029005067	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
767029005068	C-terminal domain interface [polypeptide binding]; other site
767029005069	active site
767029005070	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
767029005071	active site
767029005072	N-terminal domain interface [polypeptide binding]; other site
767029005073	Chlorite dismutase; Region: Chlor_dismutase; pfam06778
767029005074	Porphobilinogen deaminase [Coenzyme metabolism]; Region: HemC; COG0181
767029005075	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
767029005076	domain interfaces; other site
767029005077	active site
767029005078	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
767029005079	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
767029005080	active site
767029005081	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
767029005082	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
767029005083	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
767029005084	active site
767029005085	catalytic tetrad [active]
767029005086	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
767029005087	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
767029005088	Coenzyme A binding pocket [chemical binding]; other site
767029005089	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
767029005090	Protein of unknown function (DUF499); Region: DUF499; pfam04465
767029005091	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
767029005092	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
767029005093	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
767029005094	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
767029005095	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
767029005096	DEAD-like helicases superfamily; Region: DEXDc; smart00487
767029005097	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
767029005098	ATP binding site [chemical binding]; other site
767029005099	putative Mg++ binding site [ion binding]; other site
767029005100	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
767029005101	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
767029005102	nucleotide binding region [chemical binding]; other site
767029005103	ATP-binding site [chemical binding]; other site
767029005104	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
767029005105	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
767029005106	catalytic core [active]
767029005107	Oligomerisation domain; Region: Oligomerisation; pfam02410
767029005108	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
767029005109	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
767029005110	active site
767029005111	(T/H)XGH motif; other site
767029005112	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
767029005113	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
767029005114	putative catalytic cysteine [active]
767029005115	gamma-glutamyl kinase; Provisional; Region: PRK05429
767029005116	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
767029005117	nucleotide binding site [chemical binding]; other site
767029005118	homotetrameric interface [polypeptide binding]; other site
767029005119	putative phosphate binding site [ion binding]; other site
767029005120	putative allosteric binding site; other site
767029005121	PUA domain; Region: PUA; pfam01472
767029005122	GTPase CgtA; Reviewed; Region: obgE; PRK12296
767029005123	GTP1/OBG; Region: GTP1_OBG; pfam01018
767029005124	Obg GTPase; Region: Obg; cd01898
767029005125	G1 box; other site
767029005126	GTP/Mg2+ binding site [chemical binding]; other site
767029005127	Switch I region; other site
767029005128	G2 box; other site
767029005129	G3 box; other site
767029005130	Switch II region; other site
767029005131	G4 box; other site
767029005132	G5 box; other site
767029005133	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
767029005134	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
767029005135	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
767029005136	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
767029005137	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
767029005138	homodimer interface [polypeptide binding]; other site
767029005139	oligonucleotide binding site [chemical binding]; other site
767029005140	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
767029005141	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
767029005142	active site
767029005143	catalytic triad [active]
767029005144	oxyanion hole [active]
767029005145	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
767029005146	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
767029005147	Methylamine utilisation protein MauE; Region: MauE; pfam07291
767029005148	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
767029005149	Thioredoxin; Region: Thioredoxin_4; cl17273
767029005150	valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208
767029005151	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
767029005152	active site
767029005153	HIGH motif; other site
767029005154	nucleotide binding site [chemical binding]; other site
767029005155	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
767029005156	active site
767029005157	KMSKS motif; other site
767029005158	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
767029005159	tRNA binding surface [nucleotide binding]; other site
767029005160	anticodon binding site; other site
767029005161	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
767029005162	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
767029005163	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
767029005164	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
767029005165	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
767029005166	Domain interface; other site
767029005167	Peptide binding site; other site
767029005168	Active site tetrad [active]
767029005169	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
767029005170	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
767029005171	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
767029005172	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
767029005173	Walker A motif; other site
767029005174	ATP binding site [chemical binding]; other site
767029005175	Walker B motif; other site
767029005176	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
767029005177	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
767029005178	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
767029005179	oligomer interface [polypeptide binding]; other site
767029005180	active site residues [active]
767029005181	Clp protease; Region: CLP_protease; pfam00574
767029005182	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
767029005183	oligomer interface [polypeptide binding]; other site
767029005184	active site residues [active]
767029005185	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
767029005186	Domain of unknown function DUF20; Region: UPF0118; pfam01594
767029005187	trigger factor; Provisional; Region: tig; PRK01490
767029005188	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
767029005189	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
767029005190	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
767029005191	TPR motif; other site
767029005192	binding surface
767029005193	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
767029005194	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
767029005195	Walker A motif; other site
767029005196	ATP binding site [chemical binding]; other site
767029005197	Walker B motif; other site
767029005198	arginine finger; other site
767029005199	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
767029005200	binding surface
767029005201	TPR motif; other site
767029005202	TPR repeat; Region: TPR_11; pfam13414
767029005203	TPR repeat; Region: TPR_11; pfam13414
767029005204	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
767029005205	TPR motif; other site
767029005206	binding surface
767029005207	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
767029005208	TPR repeat; Region: TPR_11; pfam13414
767029005209	binding surface
767029005210	TPR motif; other site
767029005211	YCII-related domain; Region: YCII; cl00999
767029005212	Membrane protein of unknown function; Region: DUF360; pfam04020
767029005213	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
767029005214	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
767029005215	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
767029005216	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
767029005217	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
767029005218	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
767029005219	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
767029005220	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
767029005221	active site
767029005222	motif I; other site
767029005223	motif II; other site
767029005224	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
767029005225	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
767029005226	Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CarbK-RPE_like; cd07783
767029005227	N- and C-terminal domain interface [polypeptide binding]; other site
767029005228	active site
767029005229	MgATP binding site [chemical binding]; other site
767029005230	catalytic site [active]
767029005231	metal binding site [ion binding]; metal-binding site
767029005232	putative carbohydrate binding site [chemical binding]; other site
767029005233	putative homodimer interface [polypeptide binding]; other site
767029005234	Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175
767029005235	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
767029005236	active site
767029005237	metal binding site [ion binding]; metal-binding site
767029005238	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
767029005239	ribulokinase; Provisional; Region: PRK04123
767029005240	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
767029005241	nucleotide binding site [chemical binding]; other site
767029005242	Excalibur calcium-binding domain; Region: Excalibur; smart00894
767029005243	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
767029005244	Predicted permease; Region: DUF318; cl17795
767029005245	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
767029005246	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
767029005247	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
767029005248	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
767029005249	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
767029005250	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
767029005251	motif II; other site
767029005252	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
767029005253	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
767029005254	putative DNA binding site [nucleotide binding]; other site
767029005255	catalytic residue [active]
767029005256	putative H2TH interface [polypeptide binding]; other site
767029005257	putative catalytic residues [active]
767029005258	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
767029005259	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
767029005260	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
767029005261	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
767029005262	putative Mg++ binding site [ion binding]; other site
767029005263	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
767029005264	nucleotide binding region [chemical binding]; other site
767029005265	ATP-binding site [chemical binding]; other site
767029005266	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
767029005267	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
767029005268	nucleotide binding pocket [chemical binding]; other site
767029005269	K-X-D-G motif; other site
767029005270	catalytic site [active]
767029005271	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
767029005272	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
767029005273	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
767029005274	Dimer interface [polypeptide binding]; other site
767029005275	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
767029005276	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
767029005277	Zn binding site [ion binding]; other site
767029005278	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
767029005279	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
767029005280	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
767029005281	dihydroorotase; Validated; Region: pyrC; PRK09357
767029005282	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
767029005283	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
767029005284	active site
767029005285	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
767029005286	salt bridge; other site
767029005287	non-specific DNA binding site [nucleotide binding]; other site
767029005288	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
767029005289	sequence-specific DNA binding site [nucleotide binding]; other site
767029005290	Major Facilitator Superfamily; Region: MFS_1; pfam07690
767029005291	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029005292	putative substrate translocation pore; other site
767029005293	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029005294	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
767029005295	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
767029005296	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
767029005297	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
767029005298	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
767029005299	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
767029005300	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
767029005301	ATP binding site [chemical binding]; other site
767029005302	putative Mg++ binding site [ion binding]; other site
767029005303	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
767029005304	nucleotide binding region [chemical binding]; other site
767029005305	ATP-binding site [chemical binding]; other site
767029005306	DEAD/H associated; Region: DEAD_assoc; pfam08494
767029005307	peroxiredoxin; Region: AhpC; TIGR03137
767029005308	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
767029005309	dimer interface [polypeptide binding]; other site
767029005310	decamer (pentamer of dimers) interface [polypeptide binding]; other site
767029005311	catalytic triad [active]
767029005312	peroxidatic and resolving cysteines [active]
767029005313	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
767029005314	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
767029005315	catalytic residue [active]
767029005316	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
767029005317	catalytic residues [active]
767029005318	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
767029005319	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
767029005320	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
767029005321	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
767029005322	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
767029005323	dimerization interface [polypeptide binding]; other site
767029005324	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
767029005325	active site
767029005326	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
767029005327	active site
767029005328	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
767029005329	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
767029005330	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
767029005331	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
767029005332	acyl-activating enzyme (AAE) consensus motif; other site
767029005333	acyl-activating enzyme (AAE) consensus motif; other site
767029005334	putative AMP binding site [chemical binding]; other site
767029005335	putative active site [active]
767029005336	putative CoA binding site [chemical binding]; other site
767029005337	Transcriptional regulators [Transcription]; Region: MarR; COG1846
767029005338	MarR family; Region: MarR_2; pfam12802
767029005339	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
767029005340	FAD binding domain; Region: FAD_binding_4; pfam01565
767029005341	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
767029005342	CAAX protease self-immunity; Region: Abi; pfam02517
767029005343	Predicted transcriptional regulators [Transcription]; Region: COG1695
767029005344	Transcriptional regulator PadR-like family; Region: PadR; cl17335
767029005345	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029005346	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
767029005347	Walker A/P-loop; other site
767029005348	ATP binding site [chemical binding]; other site
767029005349	Q-loop/lid; other site
767029005350	ABC transporter signature motif; other site
767029005351	Walker B; other site
767029005352	D-loop; other site
767029005353	H-loop/switch region; other site
767029005354	Histidine kinase; Region: HisKA_3; pfam07730
767029005355	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029005356	ATP binding site [chemical binding]; other site
767029005357	Mg2+ binding site [ion binding]; other site
767029005358	G-X-G motif; other site
767029005359	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029005360	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029005361	active site
767029005362	phosphorylation site [posttranslational modification]
767029005363	intermolecular recognition site; other site
767029005364	dimerization interface [polypeptide binding]; other site
767029005365	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029005366	DNA binding residues [nucleotide binding]
767029005367	dimerization interface [polypeptide binding]; other site
767029005368	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
767029005369	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
767029005370	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
767029005371	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
767029005372	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
767029005373	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
767029005374	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
767029005375	excinuclease ABC subunit B; Provisional; Region: PRK05298
767029005376	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
767029005377	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
767029005378	nucleotide binding region [chemical binding]; other site
767029005379	ATP-binding site [chemical binding]; other site
767029005380	Ultra-violet resistance protein B; Region: UvrB; pfam12344
767029005381	UvrB/uvrC motif; Region: UVR; pfam02151
767029005382	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
767029005383	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
767029005384	CoA-binding site [chemical binding]; other site
767029005385	ATP-binding [chemical binding]; other site
767029005386	Uncharacterized conserved protein [Function unknown]; Region: COG1359
767029005387	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
767029005388	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
767029005389	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
767029005390	lipoyl attachment site [posttranslational modification]; other site
767029005391	glycine dehydrogenase; Provisional; Region: PRK05367
767029005392	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
767029005393	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
767029005394	catalytic residue [active]
767029005395	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
767029005396	pyridoxal 5'-phosphate binding site [chemical binding]; other site
767029005397	tetramer interface [polypeptide binding]; other site
767029005398	catalytic residue [active]
767029005399	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
767029005400	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
767029005401	RNA binding site [nucleotide binding]; other site
767029005402	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
767029005403	RNA binding site [nucleotide binding]; other site
767029005404	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
767029005405	RNA binding site [nucleotide binding]; other site
767029005406	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
767029005407	RNA binding site [nucleotide binding]; other site
767029005408	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
767029005409	active site
767029005410	catalytic site [active]
767029005411	DNA polymerase I; Provisional; Region: PRK05755
767029005412	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
767029005413	active site
767029005414	metal binding site 1 [ion binding]; metal-binding site
767029005415	putative 5' ssDNA interaction site; other site
767029005416	metal binding site 3; metal-binding site
767029005417	metal binding site 2 [ion binding]; metal-binding site
767029005418	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
767029005419	putative DNA binding site [nucleotide binding]; other site
767029005420	putative metal binding site [ion binding]; other site
767029005421	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
767029005422	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
767029005423	active site
767029005424	DNA binding site [nucleotide binding]
767029005425	catalytic site [active]
767029005426	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
767029005427	CoenzymeA binding site [chemical binding]; other site
767029005428	subunit interaction site [polypeptide binding]; other site
767029005429	PHB binding site; other site
767029005430	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
767029005431	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029005432	active site
767029005433	phosphorylation site [posttranslational modification]
767029005434	intermolecular recognition site; other site
767029005435	dimerization interface [polypeptide binding]; other site
767029005436	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
767029005437	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
767029005438	pyruvate kinase; Provisional; Region: PRK06247
767029005439	domain interfaces; other site
767029005440	active site
767029005441	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
767029005442	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
767029005443	RNA binding surface [nucleotide binding]; other site
767029005444	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
767029005445	active site
767029005446	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
767029005447	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
767029005448	DivIVA protein; Region: DivIVA; pfam05103
767029005449	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
767029005450	Protein of unknown function (DUF552); Region: DUF552; pfam04472
767029005451	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
767029005452	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
767029005453	nucleotide binding site [chemical binding]; other site
767029005454	SulA interaction site; other site
767029005455	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
767029005456	Cell division protein FtsQ; Region: FtsQ; pfam03799
767029005457	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
767029005458	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
767029005459	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
767029005460	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
767029005461	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
767029005462	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
767029005463	active site
767029005464	homodimer interface [polypeptide binding]; other site
767029005465	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
767029005466	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438
767029005467	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
767029005468	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
767029005469	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
767029005470	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
767029005471	Mg++ binding site [ion binding]; other site
767029005472	putative catalytic motif [active]
767029005473	putative substrate binding site [chemical binding]; other site
767029005474	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
767029005475	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
767029005476	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
767029005477	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
767029005478	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
767029005479	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
767029005480	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
767029005481	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
767029005482	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
767029005483	MraW methylase family; Region: Methyltransf_5; cl17771
767029005484	cell division protein MraZ; Reviewed; Region: PRK00326
767029005485	MraZ protein; Region: MraZ; pfam02381
767029005486	MraZ protein; Region: MraZ; pfam02381
767029005487	MoxR-like ATPases [General function prediction only]; Region: COG0714
767029005488	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
767029005489	ATP binding site [chemical binding]; other site
767029005490	Walker A motif; other site
767029005491	Walker B motif; other site
767029005492	arginine finger; other site
767029005493	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
767029005494	Protein of unknown function DUF58; Region: DUF58; pfam01882
767029005495	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
767029005496	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
767029005497	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
767029005498	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
767029005499	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
767029005500	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
767029005501	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
767029005502	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
767029005503	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
767029005504	Uncharacterized conserved protein [Function unknown]; Region: COG1615
767029005505	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
767029005506	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
767029005507	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
767029005508	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
767029005509	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
767029005510	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
767029005511	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
767029005512	Part of AAA domain; Region: AAA_19; pfam13245
767029005513	HRDC domain; Region: HRDC; pfam00570
767029005514	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
767029005515	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
767029005516	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
767029005517	AAA domain; Region: AAA_30; pfam13604
767029005518	Family description; Region: UvrD_C_2; pfam13538
767029005519	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
767029005520	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
767029005521	pyridoxal 5'-phosphate binding site [chemical binding]; other site
767029005522	homodimer interface [polypeptide binding]; other site
767029005523	catalytic residue [active]
767029005524	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
767029005525	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
767029005526	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
767029005527	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
767029005528	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
767029005529	DNA binding residues [nucleotide binding]
767029005530	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
767029005531	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
767029005532	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
767029005533	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
767029005534	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
767029005535	DNA binding residues [nucleotide binding]
767029005536	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
767029005537	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
767029005538	active site
767029005539	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
767029005540	catalytic triad [active]
767029005541	dimer interface [polypeptide binding]; other site
767029005542	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
767029005543	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
767029005544	ATP binding site [chemical binding]; other site
767029005545	putative Mg++ binding site [ion binding]; other site
767029005546	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
767029005547	nucleotide binding region [chemical binding]; other site
767029005548	ATP-binding site [chemical binding]; other site
767029005549	Helicase associated domain (HA2); Region: HA2; pfam04408
767029005550	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
767029005551	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
767029005552	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
767029005553	Ligand Binding Site [chemical binding]; other site
767029005554	Universal stress protein family; Region: Usp; pfam00582
767029005555	Ligand Binding Site [chemical binding]; other site
767029005556	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
767029005557	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
767029005558	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
767029005559	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
767029005560	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
767029005561	catalytic residues [active]
767029005562	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
767029005563	ResB-like family; Region: ResB; pfam05140
767029005564	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
767029005565	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
767029005566	binding surface
767029005567	TPR motif; other site
767029005568	TPR repeat; Region: TPR_11; pfam13414
767029005569	Cytochrome c552; Region: Cytochrom_C552; pfam02335
767029005570	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
767029005571	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
767029005572	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
767029005573	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
767029005574	active site
767029005575	catalytic residue [active]
767029005576	dimer interface [polypeptide binding]; other site
767029005577	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
767029005578	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029005579	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
767029005580	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
767029005581	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
767029005582	shikimate binding site; other site
767029005583	NAD(P) binding site [chemical binding]; other site
767029005584	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
767029005585	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
767029005586	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
767029005587	PYR/PP interface [polypeptide binding]; other site
767029005588	dimer interface [polypeptide binding]; other site
767029005589	TPP binding site [chemical binding]; other site
767029005590	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
767029005591	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
767029005592	TPP-binding site [chemical binding]; other site
767029005593	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
767029005594	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
767029005595	active site
767029005596	citrylCoA binding site [chemical binding]; other site
767029005597	oxalacetate binding site [chemical binding]; other site
767029005598	coenzyme A binding site [chemical binding]; other site
767029005599	catalytic triad [active]
767029005600	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
767029005601	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
767029005602	putative catalytic cysteine [active]
767029005603	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029005604	metabolite-proton symporter; Region: 2A0106; TIGR00883
767029005605	putative substrate translocation pore; other site
767029005606	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843
767029005607	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
767029005608	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
767029005609	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
767029005610	bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021
767029005611	ADP binding site [chemical binding]; other site
767029005612	magnesium binding site [ion binding]; other site
767029005613	putative shikimate binding site; other site
767029005614	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
767029005615	dimer interface [polypeptide binding]; other site
767029005616	active site
767029005617	metal binding site [ion binding]; metal-binding site
767029005618	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
767029005619	Methyltransferase domain; Region: Methyltransf_31; pfam13847
767029005620	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
767029005621	S-adenosylmethionine binding site [chemical binding]; other site
767029005622	Uncharacterized conserved protein [Function unknown]; Region: COG2966
767029005623	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
767029005624	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
767029005625	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
767029005626	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075
767029005627	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
767029005628	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
767029005629	CRISPR-associated protein; Region: TIGR03986
767029005630	CRISPR-associated protein; Region: TIGR03986
767029005631	PemK-like protein; Region: PemK; pfam02452
767029005632	vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556
767029005633	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
767029005634	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
767029005635	active site
767029005636	dimer interface [polypeptide binding]; other site
767029005637	effector binding site; other site
767029005638	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
767029005639	TSCPD domain; Region: TSCPD; pfam12637
767029005640	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
767029005641	ATP cone domain; Region: ATP-cone; pfam03477
767029005642	LexA repressor; Validated; Region: PRK00215
767029005643	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
767029005644	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
767029005645	Catalytic site [active]
767029005646	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
767029005647	HIT family signature motif; other site
767029005648	catalytic residue [active]
767029005649	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
767029005650	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
767029005651	substrate binding site [chemical binding]; other site
767029005652	glutamase interaction surface [polypeptide binding]; other site
767029005653	DEAD-like helicases superfamily; Region: DEXDc; smart00487
767029005654	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
767029005655	ATP binding site [chemical binding]; other site
767029005656	putative Mg++ binding site [ion binding]; other site
767029005657	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
767029005658	nucleotide binding region [chemical binding]; other site
767029005659	ATP-binding site [chemical binding]; other site
767029005660	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
767029005661	diacylglycerol kinase; Reviewed; Region: PRK11914
767029005662	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
767029005663	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
767029005664	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
767029005665	Predicted transcriptional regulator [Transcription]; Region: COG2378
767029005666	WYL domain; Region: WYL; pfam13280
767029005667	Predicted transcriptional regulator [Transcription]; Region: COG2378
767029005668	WYL domain; Region: WYL; pfam13280
767029005669	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
767029005670	active site
767029005671	HIGH motif; other site
767029005672	nucleotide binding site [chemical binding]; other site
767029005673	active site
767029005674	KMSKS motif; other site
767029005675	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
767029005676	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
767029005677	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
767029005678	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
767029005679	RNA binding surface [nucleotide binding]; other site
767029005680	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
767029005681	active site
767029005682	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
767029005683	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
767029005684	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
767029005685	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
767029005686	P-loop; other site
767029005687	Magnesium ion binding site [ion binding]; other site
767029005688	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
767029005689	Magnesium ion binding site [ion binding]; other site
767029005690	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
767029005691	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
767029005692	active site
767029005693	DNA binding site [nucleotide binding]
767029005694	Int/Topo IB signature motif; other site
767029005695	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
767029005696	dimer interface [polypeptide binding]; other site
767029005697	ADP-ribose binding site [chemical binding]; other site
767029005698	active site
767029005699	nudix motif; other site
767029005700	metal binding site [ion binding]; metal-binding site
767029005701	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
767029005702	Isochorismatase family; Region: Isochorismatase; pfam00857
767029005703	catalytic triad [active]
767029005704	conserved cis-peptide bond; other site
767029005705	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
767029005706	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029005707	Walker A/P-loop; other site
767029005708	ATP binding site [chemical binding]; other site
767029005709	Q-loop/lid; other site
767029005710	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
767029005711	ABC transporter signature motif; other site
767029005712	Walker B; other site
767029005713	D-loop; other site
767029005714	H-loop/switch region; other site
767029005715	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
767029005716	ATP-NAD kinase; Region: NAD_kinase; pfam01513
767029005717	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
767029005718	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
767029005719	RNA binding surface [nucleotide binding]; other site
767029005720	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
767029005721	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
767029005722	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
767029005723	active site
767029005724	motif I; other site
767029005725	motif II; other site
767029005726	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
767029005727	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
767029005728	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
767029005729	TPR motif; other site
767029005730	binding surface
767029005731	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
767029005732	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
767029005733	active site
767029005734	HIGH motif; other site
767029005735	dimer interface [polypeptide binding]; other site
767029005736	KMSKS motif; other site
767029005737	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
767029005738	RNA binding surface [nucleotide binding]; other site
767029005739	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
767029005740	dimerization interface [polypeptide binding]; other site
767029005741	putative DNA binding site [nucleotide binding]; other site
767029005742	putative Zn2+ binding site [ion binding]; other site
767029005743	argininosuccinate lyase; Provisional; Region: PRK00855
767029005744	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
767029005745	active sites [active]
767029005746	tetramer interface [polypeptide binding]; other site
767029005747	Arginine repressor [Transcription]; Region: ArgR; COG1438
767029005748	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
767029005749	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
767029005750	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
767029005751	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
767029005752	inhibitor-cofactor binding pocket; inhibition site
767029005753	pyridoxal 5'-phosphate binding site [chemical binding]; other site
767029005754	catalytic residue [active]
767029005755	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
767029005756	feedback inhibition sensing region; other site
767029005757	homohexameric interface [polypeptide binding]; other site
767029005758	nucleotide binding site [chemical binding]; other site
767029005759	N-acetyl-L-glutamate binding site [chemical binding]; other site
767029005760	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
767029005761	heterotetramer interface [polypeptide binding]; other site
767029005762	active site pocket [active]
767029005763	cleavage site
767029005764	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
767029005765	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
767029005766	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
767029005767	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
767029005768	HIGH motif; other site
767029005769	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
767029005770	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
767029005771	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
767029005772	active site
767029005773	KMSKS motif; other site
767029005774	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
767029005775	tRNA binding surface [nucleotide binding]; other site
767029005776	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029005777	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
767029005778	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
767029005779	Na binding site [ion binding]; other site
767029005780	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
767029005781	Cytochrome P450; Region: p450; cl12078
767029005782	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
767029005783	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
767029005784	putative tRNA-binding site [nucleotide binding]; other site
767029005785	B3/4 domain; Region: B3_4; pfam03483
767029005786	tRNA synthetase B5 domain; Region: B5; pfam03484
767029005787	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
767029005788	dimer interface [polypeptide binding]; other site
767029005789	motif 1; other site
767029005790	motif 3; other site
767029005791	motif 2; other site
767029005792	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
767029005793	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
767029005794	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
767029005795	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
767029005796	dimer interface [polypeptide binding]; other site
767029005797	motif 1; other site
767029005798	active site
767029005799	motif 2; other site
767029005800	motif 3; other site
767029005801	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
767029005802	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
767029005803	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
767029005804	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
767029005805	23S rRNA binding site [nucleotide binding]; other site
767029005806	L21 binding site [polypeptide binding]; other site
767029005807	L13 binding site [polypeptide binding]; other site
767029005808	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
767029005809	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
767029005810	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
767029005811	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
767029005812	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
767029005813	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
767029005814	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
767029005815	ABC-ATPase subunit  interface; other site
767029005816	dimer interface [polypeptide binding]; other site
767029005817	putative PBP binding regions; other site
767029005818	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
767029005819	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
767029005820	Walker A/P-loop; other site
767029005821	ATP binding site [chemical binding]; other site
767029005822	Q-loop/lid; other site
767029005823	ABC transporter signature motif; other site
767029005824	Walker B; other site
767029005825	D-loop; other site
767029005826	H-loop/switch region; other site
767029005827	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
767029005828	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
767029005829	intersubunit interface [polypeptide binding]; other site
767029005830	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029005831	multidrug resistance protein MdtH; Provisional; Region: PRK11646
767029005832	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
767029005833	ATP phosphoribosyltransferase; Region: HisG; cl15266
767029005834	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
767029005835	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
767029005836	metal binding site [ion binding]; metal-binding site
767029005837	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
767029005838	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
767029005839	active site
767029005840	HIGH motif; other site
767029005841	nucleotide binding site [chemical binding]; other site
767029005842	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
767029005843	active site
767029005844	KMSKS motif; other site
767029005845	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
767029005846	tRNA binding surface [nucleotide binding]; other site
767029005847	anticodon binding site; other site
767029005848	Protein of unknown function (DUF3090); Region: DUF3090; cl12832
767029005849	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
767029005850	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
767029005851	active site
767029005852	catalytic tetrad [active]
767029005853	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029005854	putative substrate translocation pore; other site
767029005855	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029005856	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029005857	WHG domain; Region: WHG; pfam13305
767029005858	pyruvate kinase; Provisional; Region: PRK06247
767029005859	Thioredoxin; Region: Thioredoxin_4; pfam13462
767029005860	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
767029005861	Family description; Region: UvrD_C_2; pfam13538
767029005862	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
767029005863	FAD binding site [chemical binding]; other site
767029005864	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
767029005865	Helix-turn-helix domain; Region: HTH_38; pfam13936
767029005866	Integrase core domain; Region: rve; pfam00665
767029005867	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
767029005868	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
767029005869	substrate binding pocket [chemical binding]; other site
767029005870	chain length determination region; other site
767029005871	substrate-Mg2+ binding site; other site
767029005872	catalytic residues [active]
767029005873	aspartate-rich region 1; other site
767029005874	active site lid residues [active]
767029005875	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
767029005876	aspartate-rich region 2; other site
767029005877	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
767029005878	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
767029005879	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
767029005880	Soluble P-type ATPase [General function prediction only]; Region: COG4087
767029005881	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
767029005882	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
767029005883	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
767029005884	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
767029005885	Walker A/P-loop; other site
767029005886	ATP binding site [chemical binding]; other site
767029005887	Q-loop/lid; other site
767029005888	ABC transporter signature motif; other site
767029005889	Walker B; other site
767029005890	D-loop; other site
767029005891	H-loop/switch region; other site
767029005892	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
767029005893	ABC-ATPase subunit  interface; other site
767029005894	dimer interface [polypeptide binding]; other site
767029005895	putative PBP binding regions; other site
767029005896	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
767029005897	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
767029005898	ABC-ATPase subunit  interface; other site
767029005899	dimer interface [polypeptide binding]; other site
767029005900	putative PBP binding regions; other site
767029005901	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
767029005902	intersubunit interface [polypeptide binding]; other site
767029005903	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
767029005904	Catalytic domain of Protein Kinases; Region: PKc; cd00180
767029005905	active site
767029005906	ATP binding site [chemical binding]; other site
767029005907	substrate binding site [chemical binding]; other site
767029005908	activation loop (A-loop); other site
767029005909	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
767029005910	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
767029005911	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
767029005912	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
767029005913	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
767029005914	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
767029005915	EamA-like transporter family; Region: EamA; pfam00892
767029005916	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
767029005917	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029005918	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029005919	active site
767029005920	phosphorylation site [posttranslational modification]
767029005921	intermolecular recognition site; other site
767029005922	dimerization interface [polypeptide binding]; other site
767029005923	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029005924	DNA binding residues [nucleotide binding]
767029005925	dimerization interface [polypeptide binding]; other site
767029005926	Histidine kinase; Region: HisKA_3; pfam07730
767029005927	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
767029005928	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
767029005929	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
767029005930	putative acyl-acceptor binding pocket; other site
767029005931	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
767029005932	NlpC/P60 family; Region: NLPC_P60; pfam00877
767029005933	hypothetical protein; Validated; Region: PRK07883
767029005934	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
767029005935	active site
767029005936	catalytic site [active]
767029005937	substrate binding site [chemical binding]; other site
767029005938	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
767029005939	GIY-YIG motif/motif A; other site
767029005940	active site
767029005941	catalytic site [active]
767029005942	putative DNA binding site [nucleotide binding]; other site
767029005943	metal binding site [ion binding]; metal-binding site
767029005944	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
767029005945	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
767029005946	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
767029005947	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
767029005948	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
767029005949	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
767029005950	phosphorylation site [posttranslational modification]
767029005951	intermolecular recognition site; other site
767029005952	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
767029005953	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
767029005954	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
767029005955	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
767029005956	active site
767029005957	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
767029005958	Glycerate kinase family; Region: Gly_kinase; cl00841
767029005959	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
767029005960	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
767029005961	Arginase family; Region: Arginase; cd09989
767029005962	agmatinase; Region: agmatinase; TIGR01230
767029005963	active site
767029005964	Mn binding site [ion binding]; other site
767029005965	oligomer interface [polypeptide binding]; other site
767029005966	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
767029005967	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
767029005968	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
767029005969	Walker A/P-loop; other site
767029005970	ATP binding site [chemical binding]; other site
767029005971	Q-loop/lid; other site
767029005972	ABC transporter signature motif; other site
767029005973	Walker B; other site
767029005974	D-loop; other site
767029005975	H-loop/switch region; other site
767029005976	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
767029005977	interface (dimer of trimers) [polypeptide binding]; other site
767029005978	Substrate-binding/catalytic site; other site
767029005979	Zn-binding sites [ion binding]; other site
767029005980	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029005981	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
767029005982	NADH(P)-binding; Region: NAD_binding_10; pfam13460
767029005983	NAD(P) binding site [chemical binding]; other site
767029005984	active site
767029005985	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
767029005986	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
767029005987	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
767029005988	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
767029005989	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
767029005990	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
767029005991	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
767029005992	E3 interaction surface; other site
767029005993	lipoyl attachment site [posttranslational modification]; other site
767029005994	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
767029005995	E3 interaction surface; other site
767029005996	lipoyl attachment site [posttranslational modification]; other site
767029005997	e3 binding domain; Region: E3_binding; pfam02817
767029005998	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
767029005999	malate dehydrogenase; Provisional; Region: PRK05442
767029006000	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
767029006001	NAD(P) binding site [chemical binding]; other site
767029006002	dimer interface [polypeptide binding]; other site
767029006003	malate binding site [chemical binding]; other site
767029006004	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
767029006005	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
767029006006	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
767029006007	homodimer interface [polypeptide binding]; other site
767029006008	NADP binding site [chemical binding]; other site
767029006009	substrate binding site [chemical binding]; other site
767029006010	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
767029006011	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
767029006012	purine monophosphate binding site [chemical binding]; other site
767029006013	dimer interface [polypeptide binding]; other site
767029006014	putative catalytic residues [active]
767029006015	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
767029006016	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
767029006017	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
767029006018	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
767029006019	active site
767029006020	cosubstrate binding site; other site
767029006021	substrate binding site [chemical binding]; other site
767029006022	catalytic site [active]
767029006023	radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053
767029006024	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
767029006025	FeS/SAM binding site; other site
767029006026	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
767029006027	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
767029006028	Part of AAA domain; Region: AAA_19; pfam13245
767029006029	Family description; Region: UvrD_C_2; pfam13538
767029006030	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
767029006031	PLD-like domain; Region: PLDc_2; pfam13091
767029006032	putative active site [active]
767029006033	catalytic site [active]
767029006034	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
767029006035	PLD-like domain; Region: PLDc_2; pfam13091
767029006036	putative active site [active]
767029006037	catalytic site [active]
767029006038	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029006039	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029006040	active site
767029006041	phosphorylation site [posttranslational modification]
767029006042	intermolecular recognition site; other site
767029006043	dimerization interface [polypeptide binding]; other site
767029006044	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029006045	dimerization interface [polypeptide binding]; other site
767029006046	DNA binding residues [nucleotide binding]
767029006047	PspC domain; Region: PspC; pfam04024
767029006048	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029006049	ATP binding site [chemical binding]; other site
767029006050	Mg2+ binding site [ion binding]; other site
767029006051	G-X-G motif; other site
767029006052	PspC domain; Region: PspC; pfam04024
767029006053	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
767029006054	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
767029006055	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
767029006056	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
767029006057	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
767029006058	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
767029006059	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
767029006060	Walker A/P-loop; other site
767029006061	ATP binding site [chemical binding]; other site
767029006062	Q-loop/lid; other site
767029006063	ABC transporter signature motif; other site
767029006064	Walker B; other site
767029006065	D-loop; other site
767029006066	H-loop/switch region; other site
767029006067	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029006068	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
767029006069	Walker A/P-loop; other site
767029006070	ATP binding site [chemical binding]; other site
767029006071	Q-loop/lid; other site
767029006072	ABC transporter signature motif; other site
767029006073	Walker B; other site
767029006074	D-loop; other site
767029006075	H-loop/switch region; other site
767029006076	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
767029006077	GMP synthase; Reviewed; Region: guaA; PRK00074
767029006078	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
767029006079	AMP/PPi binding site [chemical binding]; other site
767029006080	candidate oxyanion hole; other site
767029006081	catalytic triad [active]
767029006082	potential glutamine specificity residues [chemical binding]; other site
767029006083	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
767029006084	ATP Binding subdomain [chemical binding]; other site
767029006085	Ligand Binding sites [chemical binding]; other site
767029006086	Dimerization subdomain; other site
767029006087	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
767029006088	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
767029006089	dimer interface [polypeptide binding]; other site
767029006090	pyridoxal 5'-phosphate binding site [chemical binding]; other site
767029006091	catalytic residue [active]
767029006092	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
767029006093	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
767029006094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029006095	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
767029006096	Walker A/P-loop; other site
767029006097	ATP binding site [chemical binding]; other site
767029006098	Q-loop/lid; other site
767029006099	ABC transporter signature motif; other site
767029006100	Walker B; other site
767029006101	D-loop; other site
767029006102	H-loop/switch region; other site
767029006103	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029006104	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
767029006105	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
767029006106	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
767029006107	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
767029006108	Helix-turn-helix domain; Region: HTH_38; pfam13936
767029006109	Integrase core domain; Region: rve; pfam00665
767029006110	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
767029006111	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
767029006112	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
767029006113	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
767029006114	Walker A/P-loop; other site
767029006115	ATP binding site [chemical binding]; other site
767029006116	Q-loop/lid; other site
767029006117	ABC transporter signature motif; other site
767029006118	Walker B; other site
767029006119	D-loop; other site
767029006120	H-loop/switch region; other site
767029006121	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
767029006122	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
767029006123	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
767029006124	ABC-ATPase subunit  interface; other site
767029006125	dimer interface [polypeptide binding]; other site
767029006126	putative PBP binding regions; other site
767029006127	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
767029006128	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
767029006129	intersubunit interface [polypeptide binding]; other site
767029006130	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029006131	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
767029006132	DNA-binding interface [nucleotide binding]; DNA binding site
767029006133	chorismate mutase; Provisional; Region: PRK09239
767029006134	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
767029006135	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
767029006136	active site
767029006137	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
767029006138	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
767029006139	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
767029006140	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
767029006141	active site
767029006142	Predicted membrane protein [Function unknown]; Region: COG2860
767029006143	UPF0126 domain; Region: UPF0126; pfam03458
767029006144	UPF0126 domain; Region: UPF0126; pfam03458
767029006145	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
767029006146	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
767029006147	homodimer interface [polypeptide binding]; other site
767029006148	substrate-cofactor binding pocket; other site
767029006149	catalytic residue [active]
767029006150	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
767029006151	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
767029006152	NAD binding site [chemical binding]; other site
767029006153	sugar binding site [chemical binding]; other site
767029006154	divalent metal binding site [ion binding]; other site
767029006155	tetramer (dimer of dimers) interface [polypeptide binding]; other site
767029006156	dimer interface [polypeptide binding]; other site
767029006157	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
767029006158	Sulfatase; Region: Sulfatase; cl17466
767029006159	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
767029006160	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
767029006161	ring oligomerisation interface [polypeptide binding]; other site
767029006162	ATP/Mg binding site [chemical binding]; other site
767029006163	stacking interactions; other site
767029006164	hinge regions; other site
767029006165	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
767029006166	oligomerisation interface [polypeptide binding]; other site
767029006167	mobile loop; other site
767029006168	roof hairpin; other site
767029006169	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
767029006170	active site
767029006171	NTP binding site [chemical binding]; other site
767029006172	metal binding triad [ion binding]; metal-binding site
767029006173	antibiotic binding site [chemical binding]; other site
767029006174	Methyltransferase domain; Region: Methyltransf_18; pfam12847
767029006175	S-adenosylmethionine binding site [chemical binding]; other site
767029006176	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
767029006177	RNA binding surface [nucleotide binding]; other site
767029006178	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
767029006179	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
767029006180	Walker A/P-loop; other site
767029006181	ATP binding site [chemical binding]; other site
767029006182	Q-loop/lid; other site
767029006183	ABC transporter signature motif; other site
767029006184	Walker B; other site
767029006185	D-loop; other site
767029006186	H-loop/switch region; other site
767029006187	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
767029006188	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
767029006189	Walker A/P-loop; other site
767029006190	ATP binding site [chemical binding]; other site
767029006191	Q-loop/lid; other site
767029006192	ABC transporter signature motif; other site
767029006193	Walker B; other site
767029006194	D-loop; other site
767029006195	H-loop/switch region; other site
767029006196	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
767029006197	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
767029006198	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029006199	dimer interface [polypeptide binding]; other site
767029006200	conserved gate region; other site
767029006201	putative PBP binding loops; other site
767029006202	ABC-ATPase subunit interface; other site
767029006203	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
767029006204	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
767029006205	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
767029006206	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029006207	putative PBP binding loops; other site
767029006208	dimer interface [polypeptide binding]; other site
767029006209	ABC-ATPase subunit interface; other site
767029006210	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
767029006211	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
767029006212	UGMP family protein; Validated; Region: PRK09604
767029006213	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
767029006214	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
767029006215	Glycoprotease family; Region: Peptidase_M22; pfam00814
767029006216	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
767029006217	Coenzyme A binding pocket [chemical binding]; other site
767029006218	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
767029006219	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029006220	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029006221	Major Facilitator Superfamily; Region: MFS_1; pfam07690
767029006222	putative substrate translocation pore; other site
767029006223	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
767029006224	putative substrate binding site [chemical binding]; other site
767029006225	putative ATP binding site [chemical binding]; other site
767029006226	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
767029006227	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
767029006228	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
767029006229	glutaminase active site [active]
767029006230	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
767029006231	dimer interface [polypeptide binding]; other site
767029006232	active site
767029006233	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
767029006234	dimer interface [polypeptide binding]; other site
767029006235	active site
767029006236	NAD synthetase; Reviewed; Region: nadE; PRK02628
767029006237	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
767029006238	multimer interface [polypeptide binding]; other site
767029006239	active site
767029006240	catalytic triad [active]
767029006241	protein interface 1 [polypeptide binding]; other site
767029006242	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
767029006243	homodimer interface [polypeptide binding]; other site
767029006244	NAD binding pocket [chemical binding]; other site
767029006245	ATP binding pocket [chemical binding]; other site
767029006246	Mg binding site [ion binding]; other site
767029006247	active-site loop [active]
767029006248	pantothenate kinase; Provisional; Region: PRK05439
767029006249	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
767029006250	ATP-binding site [chemical binding]; other site
767029006251	CoA-binding site [chemical binding]; other site
767029006252	Mg2+-binding site [ion binding]; other site
767029006253	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
767029006254	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
767029006255	active site
767029006256	substrate binding site [chemical binding]; other site
767029006257	metal binding site [ion binding]; metal-binding site
767029006258	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
767029006259	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
767029006260	23S rRNA interface [nucleotide binding]; other site
767029006261	L3 interface [polypeptide binding]; other site
767029006262	Fic/DOC family; Region: Fic; pfam02661
767029006263	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
767029006264	DNA binding site [nucleotide binding]
767029006265	active site
767029006266	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
767029006267	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
767029006268	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
767029006269	AlkA N-terminal domain; Region: AlkA_N; cl05528
767029006270	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
767029006271	endonuclease III; Region: ENDO3c; smart00478
767029006272	minor groove reading motif; other site
767029006273	helix-hairpin-helix signature motif; other site
767029006274	substrate binding pocket [chemical binding]; other site
767029006275	active site
767029006276	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
767029006277	elongation factor G; Reviewed; Region: PRK12740
767029006278	G1 box; other site
767029006279	GTP/Mg2+ binding site [chemical binding]; other site
767029006280	G2 box; other site
767029006281	Switch I region; other site
767029006282	G3 box; other site
767029006283	Switch II region; other site
767029006284	G4 box; other site
767029006285	G5 box; other site
767029006286	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
767029006287	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
767029006288	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
767029006289	hypothetical protein; Provisional; Region: PRK11770
767029006290	Domain of unknown function (DUF307); Region: DUF307; pfam03733
767029006291	Domain of unknown function (DUF307); Region: DUF307; pfam03733
767029006292	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
767029006293	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
767029006294	Walker A/P-loop; other site
767029006295	ATP binding site [chemical binding]; other site
767029006296	Q-loop/lid; other site
767029006297	ABC transporter signature motif; other site
767029006298	Walker B; other site
767029006299	D-loop; other site
767029006300	H-loop/switch region; other site
767029006301	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
767029006302	ABC-ATPase subunit  interface; other site
767029006303	dimer interface [polypeptide binding]; other site
767029006304	putative PBP binding regions; other site
767029006305	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
767029006306	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
767029006307	putative ligand binding site [chemical binding]; other site
767029006308	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
767029006309	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
767029006310	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
767029006311	dimerization interface 3.5A [polypeptide binding]; other site
767029006312	active site
767029006313	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
767029006314	S-adenosylmethionine binding site [chemical binding]; other site
767029006315	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
767029006316	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
767029006317	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
767029006318	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
767029006319	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
767029006320	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
767029006321	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029006322	dimer interface [polypeptide binding]; other site
767029006323	conserved gate region; other site
767029006324	putative PBP binding loops; other site
767029006325	ABC-ATPase subunit interface; other site
767029006326	antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111
767029006327	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029006328	dimer interface [polypeptide binding]; other site
767029006329	conserved gate region; other site
767029006330	ABC-ATPase subunit interface; other site
767029006331	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
767029006332	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
767029006333	Walker A/P-loop; other site
767029006334	ATP binding site [chemical binding]; other site
767029006335	Q-loop/lid; other site
767029006336	ABC transporter signature motif; other site
767029006337	Walker B; other site
767029006338	D-loop; other site
767029006339	H-loop/switch region; other site
767029006340	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
767029006341	Walker A/P-loop; other site
767029006342	ATP binding site [chemical binding]; other site
767029006343	Q-loop/lid; other site
767029006344	ABC transporter signature motif; other site
767029006345	Walker B; other site
767029006346	D-loop; other site
767029006347	H-loop/switch region; other site
767029006348	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
767029006349	RDD family; Region: RDD; pfam06271
767029006350	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
767029006351	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
767029006352	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
767029006353	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
767029006354	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
767029006355	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
767029006356	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
767029006357	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
767029006358	DJ-1 family protein; Region: not_thiJ; TIGR01383
767029006359	conserved cys residue [active]
767029006360	dimerization interface [polypeptide binding]; other site
767029006361	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
767029006362	putative active cleft [active]
767029006363	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
767029006364	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
767029006365	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
767029006366	alphaNTD homodimer interface [polypeptide binding]; other site
767029006367	alphaNTD - beta interaction site [polypeptide binding]; other site
767029006368	alphaNTD - beta' interaction site [polypeptide binding]; other site
767029006369	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
767029006370	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
767029006371	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
767029006372	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
767029006373	RNA binding surface [nucleotide binding]; other site
767029006374	30S ribosomal protein S11; Validated; Region: PRK05309
767029006375	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
767029006376	30S ribosomal protein S13; Region: bact_S13; TIGR03631
767029006377	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
767029006378	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
767029006379	rRNA binding site [nucleotide binding]; other site
767029006380	predicted 30S ribosome binding site; other site
767029006381	YCII-related domain; Region: YCII; cl00999
767029006382	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
767029006383	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
767029006384	active site
767029006385	adenylate kinase; Reviewed; Region: adk; PRK00279
767029006386	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
767029006387	AMP-binding site [chemical binding]; other site
767029006388	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
767029006389	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
767029006390	SecY translocase; Region: SecY; pfam00344
767029006391	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
767029006392	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
767029006393	active site
767029006394	homodimer interface [polypeptide binding]; other site
767029006395	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
767029006396	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
767029006397	23S rRNA binding site [nucleotide binding]; other site
767029006398	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
767029006399	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
767029006400	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
767029006401	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
767029006402	5S rRNA interface [nucleotide binding]; other site
767029006403	L27 interface [polypeptide binding]; other site
767029006404	23S rRNA interface [nucleotide binding]; other site
767029006405	L5 interface [polypeptide binding]; other site
767029006406	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
767029006407	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
767029006408	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
767029006409	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
767029006410	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
767029006411	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
767029006412	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
767029006413	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
767029006414	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
767029006415	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
767029006416	RNA binding site [nucleotide binding]; other site
767029006417	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
767029006418	GAD-like domain; Region: GAD-like; pfam08887
767029006419	Domain of unknown function (DUF1851); Region: DUF1851; pfam08906
767029006420	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
767029006421	Peptidase family M23; Region: Peptidase_M23; pfam01551
767029006422	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
767029006423	NlpC/P60 family; Region: NLPC_P60; pfam00877
767029006424	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
767029006425	AAA-like domain; Region: AAA_10; pfam12846
767029006426	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
767029006427	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
767029006428	Walker A motif; other site
767029006429	ATP binding site [chemical binding]; other site
767029006430	Walker B motif; other site
767029006431	GAD-like domain; Region: GAD-like; pfam08887
767029006432	Domain of unknown function (DUF1851); Region: DUF1851; pfam08906
767029006433	PQQ-like domain; Region: PQQ_2; pfam13360
767029006434	PQQ-like domain; Region: PQQ_2; pfam13360
767029006435	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
767029006436	Ferritin-like domain; Region: Ferritin; pfam00210
767029006437	ferroxidase diiron center [ion binding]; other site
767029006438	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
767029006439	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
767029006440	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
767029006441	Walker A/P-loop; other site
767029006442	ATP binding site [chemical binding]; other site
767029006443	Q-loop/lid; other site
767029006444	ABC transporter signature motif; other site
767029006445	Walker B; other site
767029006446	D-loop; other site
767029006447	H-loop/switch region; other site
767029006448	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
767029006449	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
767029006450	dimer interface [polypeptide binding]; other site
767029006451	phosphorylation site [posttranslational modification]
767029006452	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029006453	ATP binding site [chemical binding]; other site
767029006454	Mg2+ binding site [ion binding]; other site
767029006455	G-X-G motif; other site
767029006456	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
767029006457	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029006458	active site
767029006459	phosphorylation site [posttranslational modification]
767029006460	intermolecular recognition site; other site
767029006461	dimerization interface [polypeptide binding]; other site
767029006462	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
767029006463	DNA binding site [nucleotide binding]
767029006464	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
767029006465	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
767029006466	23S rRNA interface [nucleotide binding]; other site
767029006467	putative translocon interaction site; other site
767029006468	signal recognition particle (SRP54) interaction site; other site
767029006469	L23 interface [polypeptide binding]; other site
767029006470	trigger factor interaction site; other site
767029006471	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
767029006472	23S rRNA interface [nucleotide binding]; other site
767029006473	5S rRNA interface [nucleotide binding]; other site
767029006474	putative antibiotic binding site [chemical binding]; other site
767029006475	L25 interface [polypeptide binding]; other site
767029006476	L27 interface [polypeptide binding]; other site
767029006477	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
767029006478	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
767029006479	G-X-X-G motif; other site
767029006480	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
767029006481	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
767029006482	putative translocon binding site; other site
767029006483	protein-rRNA interface [nucleotide binding]; other site
767029006484	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
767029006485	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
767029006486	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
767029006487	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
767029006488	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
767029006489	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
767029006490	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
767029006491	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
767029006492	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029006493	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029006494	active site
767029006495	phosphorylation site [posttranslational modification]
767029006496	intermolecular recognition site; other site
767029006497	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029006498	DNA binding residues [nucleotide binding]
767029006499	Histidine kinase; Region: HisKA_3; pfam07730
767029006500	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029006501	ATP binding site [chemical binding]; other site
767029006502	Mg2+ binding site [ion binding]; other site
767029006503	G-X-G motif; other site
767029006504	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
767029006505	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
767029006506	Walker A/P-loop; other site
767029006507	ATP binding site [chemical binding]; other site
767029006508	Q-loop/lid; other site
767029006509	ABC transporter signature motif; other site
767029006510	Walker B; other site
767029006511	D-loop; other site
767029006512	H-loop/switch region; other site
767029006513	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
767029006514	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
767029006515	active site
767029006516	HIGH motif; other site
767029006517	KMSKS motif; other site
767029006518	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
767029006519	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
767029006520	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
767029006521	active site
767029006522	HIGH motif; other site
767029006523	nucleotide binding site [chemical binding]; other site
767029006524	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
767029006525	active site
767029006526	KMSKS motif; other site
767029006527	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
767029006528	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
767029006529	Mechanosensitive ion channel; Region: MS_channel; pfam00924
767029006530	elongation factor Tu; Reviewed; Region: PRK00049
767029006531	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
767029006532	G1 box; other site
767029006533	GEF interaction site [polypeptide binding]; other site
767029006534	GTP/Mg2+ binding site [chemical binding]; other site
767029006535	Switch I region; other site
767029006536	G2 box; other site
767029006537	G3 box; other site
767029006538	Switch II region; other site
767029006539	G4 box; other site
767029006540	G5 box; other site
767029006541	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
767029006542	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
767029006543	Antibiotic Binding Site [chemical binding]; other site
767029006544	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
767029006545	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
767029006546	elongation factor G; Reviewed; Region: PRK00007
767029006547	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
767029006548	G1 box; other site
767029006549	putative GEF interaction site [polypeptide binding]; other site
767029006550	GTP/Mg2+ binding site [chemical binding]; other site
767029006551	Switch I region; other site
767029006552	G2 box; other site
767029006553	G3 box; other site
767029006554	Switch II region; other site
767029006555	G4 box; other site
767029006556	G5 box; other site
767029006557	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
767029006558	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
767029006559	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
767029006560	30S ribosomal protein S7; Validated; Region: PRK05302
767029006561	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
767029006562	S17 interaction site [polypeptide binding]; other site
767029006563	S8 interaction site; other site
767029006564	16S rRNA interaction site [nucleotide binding]; other site
767029006565	streptomycin interaction site [chemical binding]; other site
767029006566	23S rRNA interaction site [nucleotide binding]; other site
767029006567	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
767029006568	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
767029006569	DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386
767029006570	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
767029006571	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
767029006572	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
767029006573	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
767029006574	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
767029006575	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
767029006576	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
767029006577	DNA binding site [nucleotide binding]
767029006578	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
767029006579	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
767029006580	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
767029006581	RPB12 interaction site [polypeptide binding]; other site
767029006582	RPB1 interaction site [polypeptide binding]; other site
767029006583	RPB10 interaction site [polypeptide binding]; other site
767029006584	RPB11 interaction site [polypeptide binding]; other site
767029006585	RPB3 interaction site [polypeptide binding]; other site
767029006586	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630
767029006587	putative active site [active]
767029006588	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
767029006589	core dimer interface [polypeptide binding]; other site
767029006590	peripheral dimer interface [polypeptide binding]; other site
767029006591	L10 interface [polypeptide binding]; other site
767029006592	L11 interface [polypeptide binding]; other site
767029006593	putative EF-Tu interaction site [polypeptide binding]; other site
767029006594	putative EF-G interaction site [polypeptide binding]; other site
767029006595	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
767029006596	23S rRNA interface [nucleotide binding]; other site
767029006597	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
767029006598	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
767029006599	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
767029006600	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029006601	Walker A/P-loop; other site
767029006602	ATP binding site [chemical binding]; other site
767029006603	Q-loop/lid; other site
767029006604	ABC transporter signature motif; other site
767029006605	Walker B; other site
767029006606	D-loop; other site
767029006607	H-loop/switch region; other site
767029006608	Domain of unknown function (DUF4375); Region: DUF4375; pfam14300
767029006609	Domain of unknown function (DUF4261); Region: DUF4261; pfam14080
767029006610	NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285
767029006611	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
767029006612	tetramer interface [polypeptide binding]; other site
767029006613	catalytic Zn binding site [ion binding]; other site
767029006614	NADP binding site [chemical binding]; other site
767029006615	Predicted transcriptional regulator [Transcription]; Region: COG2378
767029006616	HTH domain; Region: HTH_11; pfam08279
767029006617	WYL domain; Region: WYL; pfam13280
767029006618	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261
767029006619	putative dimer interface [polypeptide binding]; other site
767029006620	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
767029006621	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
767029006622	AAA domain; Region: AAA_14; pfam13173
767029006623	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
767029006624	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
767029006625	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
767029006626	Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834
767029006627	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
767029006628	putative active site [active]
767029006629	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
767029006630	mRNA/rRNA interface [nucleotide binding]; other site
767029006631	Ribosomal protein L11/L12; Region: RL11; smart00649
767029006632	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
767029006633	putative thiostrepton binding site; other site
767029006634	23S rRNA interface [nucleotide binding]; other site
767029006635	L7/L12 interface [polypeptide binding]; other site
767029006636	L25 interface [polypeptide binding]; other site
767029006637	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
767029006638	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
767029006639	putative homodimer interface [polypeptide binding]; other site
767029006640	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
767029006641	heterodimer interface [polypeptide binding]; other site
767029006642	homodimer interface [polypeptide binding]; other site
767029006643	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
767029006644	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
767029006645	FAD binding domain; Region: FAD_binding_4; pfam01565
767029006646	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
767029006647	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
767029006648	active site 2 [active]
767029006649	active site 1 [active]
767029006650	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
767029006651	active site
767029006652	catalytic site [active]
767029006653	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
767029006654	CAAX protease self-immunity; Region: Abi; pfam02517
767029006655	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
767029006656	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
767029006657	active site
767029006658	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
767029006659	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
767029006660	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
767029006661	HTH domain; Region: HTH_11; pfam08279
767029006662	PRD domain; Region: PRD; pfam00874
767029006663	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
767029006664	active site
767029006665	P-loop; other site
767029006666	phosphorylation site [posttranslational modification]
767029006667	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
767029006668	active site
767029006669	phosphorylation site [posttranslational modification]
767029006670	Glucitol operon activator protein (GutM); Region: GutM; pfam06923
767029006671	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608
767029006672	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
767029006673	PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825
767029006674	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
767029006675	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829
767029006676	Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175
767029006677	active site
767029006678	metal binding site [ion binding]; metal-binding site
767029006679	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
767029006680	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
767029006681	DNA-binding site [nucleotide binding]; DNA binding site
767029006682	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
767029006683	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
767029006684	Walker A/P-loop; other site
767029006685	ATP binding site [chemical binding]; other site
767029006686	Q-loop/lid; other site
767029006687	ABC transporter signature motif; other site
767029006688	Walker B; other site
767029006689	D-loop; other site
767029006690	H-loop/switch region; other site
767029006691	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
767029006692	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
767029006693	active site
767029006694	metal binding site [ion binding]; metal-binding site
767029006695	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
767029006696	Predicted amidohydrolase [General function prediction only]; Region: COG0388
767029006697	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
767029006698	putative active site [active]
767029006699	catalytic triad [active]
767029006700	putative dimer interface [polypeptide binding]; other site
767029006701	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029006702	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029006703	active site
767029006704	phosphorylation site [posttranslational modification]
767029006705	intermolecular recognition site; other site
767029006706	dimerization interface [polypeptide binding]; other site
767029006707	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029006708	DNA binding residues [nucleotide binding]
767029006709	dimerization interface [polypeptide binding]; other site
767029006710	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
767029006711	Histidine kinase; Region: HisKA_3; pfam07730
767029006712	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
767029006713	Histidine kinase; Region: HisKA_3; pfam07730
767029006714	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
767029006715	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
767029006716	H+ Antiporter protein; Region: 2A0121; TIGR00900
767029006717	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029006718	putative substrate translocation pore; other site
767029006719	FtsX-like permease family; Region: FtsX; pfam02687
767029006720	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
767029006721	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
767029006722	Walker A/P-loop; other site
767029006723	ATP binding site [chemical binding]; other site
767029006724	Q-loop/lid; other site
767029006725	ABC transporter signature motif; other site
767029006726	Walker B; other site
767029006727	D-loop; other site
767029006728	H-loop/switch region; other site
767029006729	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
767029006730	active site
767029006731	catalytic triad [active]
767029006732	oxyanion hole [active]
767029006733	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
767029006734	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
767029006735	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
767029006736	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
767029006737	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
767029006738	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
767029006739	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
767029006740	dimer interface [polypeptide binding]; other site
767029006741	ssDNA binding site [nucleotide binding]; other site
767029006742	tetramer (dimer of dimers) interface [polypeptide binding]; other site
767029006743	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
767029006744	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
767029006745	active site
767029006746	catalytic triad [active]
767029006747	oxyanion hole [active]
767029006748	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
767029006749	active site residue [active]
767029006750	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
767029006751	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
767029006752	Walker A/P-loop; other site
767029006753	ATP binding site [chemical binding]; other site
767029006754	Q-loop/lid; other site
767029006755	ABC transporter signature motif; other site
767029006756	Walker B; other site
767029006757	D-loop; other site
767029006758	H-loop/switch region; other site
767029006759	FtsX-like permease family; Region: FtsX; pfam02687
767029006760	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
767029006761	putative FMN binding site [chemical binding]; other site
767029006762	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
767029006763	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
767029006764	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
767029006765	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
767029006766	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
767029006767	acyl-activating enzyme (AAE) consensus motif; other site
767029006768	putative AMP binding site [chemical binding]; other site
767029006769	putative active site [active]
767029006770	putative CoA binding site [chemical binding]; other site
767029006771	AAA domain; Region: AAA_14; pfam13173
767029006772	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
767029006773	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
767029006774	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
767029006775	DNA binding residues [nucleotide binding]
767029006776	drug binding residues [chemical binding]; other site
767029006777	dimer interface [polypeptide binding]; other site
767029006778	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
767029006779	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
767029006780	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
767029006781	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
767029006782	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
767029006783	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
767029006784	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
767029006785	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
767029006786	Methyltransferase domain; Region: Methyltransf_23; pfam13489
767029006787	Methyltransferase domain; Region: Methyltransf_12; pfam08242
767029006788	Methyltransferase domain; Region: Methyltransf_31; pfam13847
767029006789	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
767029006790	S-adenosylmethionine binding site [chemical binding]; other site
767029006791	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
767029006792	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
767029006793	putative catalytic site [active]
767029006794	putative metal binding site [ion binding]; other site
767029006795	putative phosphate binding site [ion binding]; other site
767029006796	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
767029006797	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
767029006798	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
767029006799	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
767029006800	dimer interface [polypeptide binding]; other site
767029006801	PYR/PP interface [polypeptide binding]; other site
767029006802	TPP binding site [chemical binding]; other site
767029006803	substrate binding site [chemical binding]; other site
767029006804	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
767029006805	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
767029006806	TPP-binding site [chemical binding]; other site
767029006807	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
767029006808	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
767029006809	MoxR-like ATPases [General function prediction only]; Region: COG0714
767029006810	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
767029006811	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
767029006812	metal ion-dependent adhesion site (MIDAS); other site
767029006813	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
767029006814	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
767029006815	substrate binding pocket [chemical binding]; other site
767029006816	chain length determination region; other site
767029006817	substrate-Mg2+ binding site; other site
767029006818	catalytic residues [active]
767029006819	aspartate-rich region 1; other site
767029006820	active site lid residues [active]
767029006821	aspartate-rich region 2; other site
767029006822	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
767029006823	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
767029006824	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
767029006825	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
767029006826	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
767029006827	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
767029006828	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
767029006829	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
767029006830	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
767029006831	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
767029006832	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
767029006833	4Fe-4S binding domain; Region: Fer4; pfam00037
767029006834	4Fe-4S binding domain; Region: Fer4; pfam00037
767029006835	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
767029006836	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
767029006837	NADH dehydrogenase subunit G; Validated; Region: PRK07860
767029006838	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
767029006839	catalytic loop [active]
767029006840	iron binding site [ion binding]; other site
767029006841	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
767029006842	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
767029006843	molybdopterin cofactor binding site; other site
767029006844	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
767029006845	molybdopterin cofactor binding site; other site
767029006846	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
767029006847	SLBB domain; Region: SLBB; pfam10531
767029006848	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
767029006849	NADH dehydrogenase subunit E; Validated; Region: PRK07539
767029006850	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
767029006851	putative dimer interface [polypeptide binding]; other site
767029006852	[2Fe-2S] cluster binding site [ion binding]; other site
767029006853	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
767029006854	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
767029006855	NADH dehydrogenase subunit D; Validated; Region: PRK06075
767029006856	NADH dehydrogenase subunit C; Provisional; Region: PRK07785
767029006857	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
767029006858	NADH dehydrogenase subunit B; Validated; Region: PRK06411
767029006859	NADH dehydrogenase subunit A; Validated; Region: PRK07928
767029006860	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
767029006861	isochorismate synthase EntC; Provisional; Region: PRK15016
767029006862	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
767029006863	heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189
767029006864	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
767029006865	Walker A/P-loop; other site
767029006866	ATP binding site [chemical binding]; other site
767029006867	Q-loop/lid; other site
767029006868	ABC transporter signature motif; other site
767029006869	Walker B; other site
767029006870	D-loop; other site
767029006871	H-loop/switch region; other site
767029006872	glycogen branching enzyme; Provisional; Region: PRK14705
767029006873	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
767029006874	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
767029006875	S-adenosylmethionine binding site [chemical binding]; other site
767029006876	RNase_H superfamily; Region: RNase_H_2; pfam13482
767029006877	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
767029006878	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
767029006879	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
767029006880	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
767029006881	ligand binding site [chemical binding]; other site
767029006882	homodimer interface [polypeptide binding]; other site
767029006883	NAD(P) binding site [chemical binding]; other site
767029006884	trimer interface B [polypeptide binding]; other site
767029006885	trimer interface A [polypeptide binding]; other site
767029006886	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
767029006887	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
767029006888	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
767029006889	dimer interface [polypeptide binding]; other site
767029006890	tetramer interface [polypeptide binding]; other site
767029006891	PYR/PP interface [polypeptide binding]; other site
767029006892	TPP binding site [chemical binding]; other site
767029006893	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
767029006894	TPP-binding site [chemical binding]; other site
767029006895	O-succinylbenzoate synthase; Provisional; Region: PRK02901
767029006896	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
767029006897	active site
767029006898	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
767029006899	UbiA prenyltransferase family; Region: UbiA; pfam01040
767029006900	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
767029006901	AMP binding site [chemical binding]; other site
767029006902	active site
767029006903	acyl-activating enzyme (AAE) consensus motif; other site
767029006904	CoA binding site [chemical binding]; other site
767029006905	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
767029006906	DAK2 domain; Region: Dak2; cl03685
767029006907	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
767029006908	active site
767029006909	Substrate binding site; other site
767029006910	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
767029006911	galactokinase; Provisional; Region: PRK03817
767029006912	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029006913	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029006914	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
767029006915	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
767029006916	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029006917	Walker A/P-loop; other site
767029006918	ATP binding site [chemical binding]; other site
767029006919	Q-loop/lid; other site
767029006920	ABC transporter signature motif; other site
767029006921	Walker B; other site
767029006922	D-loop; other site
767029006923	H-loop/switch region; other site
767029006924	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029006925	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
767029006926	Walker A/P-loop; other site
767029006927	ATP binding site [chemical binding]; other site
767029006928	Q-loop/lid; other site
767029006929	ABC transporter signature motif; other site
767029006930	Walker B; other site
767029006931	D-loop; other site
767029006932	H-loop/switch region; other site
767029006933	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
767029006934	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
767029006935	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
767029006936	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
767029006937	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029006938	dimer interface [polypeptide binding]; other site
767029006939	conserved gate region; other site
767029006940	putative PBP binding loops; other site
767029006941	ABC-ATPase subunit interface; other site
767029006942	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
767029006943	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
767029006944	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
767029006945	Walker A/P-loop; other site
767029006946	ATP binding site [chemical binding]; other site
767029006947	Q-loop/lid; other site
767029006948	ABC transporter signature motif; other site
767029006949	Walker B; other site
767029006950	D-loop; other site
767029006951	H-loop/switch region; other site
767029006952	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
767029006953	Walker A/P-loop; other site
767029006954	ATP binding site [chemical binding]; other site
767029006955	Q-loop/lid; other site
767029006956	ABC transporter signature motif; other site
767029006957	Walker B; other site
767029006958	D-loop; other site
767029006959	H-loop/switch region; other site
767029006960	Uncharacterized conserved protein [Function unknown]; Region: COG1434
767029006961	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
767029006962	putative active site [active]
767029006963	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
767029006964	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
767029006965	S-adenosylmethionine binding site [chemical binding]; other site
767029006966	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
767029006967	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
767029006968	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
767029006969	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
767029006970	Flavoprotein; Region: Flavoprotein; pfam02441
767029006971	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
767029006972	glycerol kinase; Provisional; Region: glpK; PRK00047
767029006973	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
767029006974	N- and C-terminal domain interface [polypeptide binding]; other site
767029006975	active site
767029006976	MgATP binding site [chemical binding]; other site
767029006977	catalytic site [active]
767029006978	metal binding site [ion binding]; metal-binding site
767029006979	putative homotetramer interface [polypeptide binding]; other site
767029006980	glycerol binding site [chemical binding]; other site
767029006981	homodimer interface [polypeptide binding]; other site
767029006982	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
767029006983	amphipathic channel; other site
767029006984	Asn-Pro-Ala signature motifs; other site
767029006985	Transcriptional regulator [Transcription]; Region: LysR; COG0583
767029006986	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
767029006987	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
767029006988	dimerization interface [polypeptide binding]; other site
767029006989	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
767029006990	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
767029006991	active site
767029006992	catalytic tetrad [active]
767029006993	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
767029006994	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
767029006995	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
767029006996	NADH(P)-binding; Region: NAD_binding_10; pfam13460
767029006997	NAD(P) binding site [chemical binding]; other site
767029006998	active site
767029006999	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
767029007000	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
767029007001	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
767029007002	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
767029007003	active site
767029007004	catalytic tetrad [active]
767029007005	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
767029007006	TAP-like protein; Region: Abhydrolase_4; pfam08386
767029007007	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
767029007008	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
767029007009	putative NAD(P) binding site [chemical binding]; other site
767029007010	Predicted transcriptional regulators [Transcription]; Region: COG1733
767029007011	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
767029007012	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029007013	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029007014	active site
767029007015	phosphorylation site [posttranslational modification]
767029007016	intermolecular recognition site; other site
767029007017	dimerization interface [polypeptide binding]; other site
767029007018	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029007019	DNA binding residues [nucleotide binding]
767029007020	dimerization interface [polypeptide binding]; other site
767029007021	Histidine kinase; Region: HisKA_3; pfam07730
767029007022	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029007023	ATP binding site [chemical binding]; other site
767029007024	Mg2+ binding site [ion binding]; other site
767029007025	G-X-G motif; other site
767029007026	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
767029007027	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
767029007028	Walker A/P-loop; other site
767029007029	ATP binding site [chemical binding]; other site
767029007030	Q-loop/lid; other site
767029007031	ABC transporter signature motif; other site
767029007032	Walker B; other site
767029007033	D-loop; other site
767029007034	H-loop/switch region; other site
767029007035	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
767029007036	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
767029007037	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
767029007038	active site
767029007039	catalytic tetrad [active]
767029007040	AAA domain; Region: AAA_14; pfam13173
767029007041	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
767029007042	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
767029007043	Transcriptional regulator [Transcription]; Region: LysR; COG0583
767029007044	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
767029007045	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
767029007046	dimerization interface [polypeptide binding]; other site
767029007047	Predicted membrane protein [Function unknown]; Region: COG1511
767029007048	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
767029007049	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
767029007050	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
767029007051	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029007052	Walker A/P-loop; other site
767029007053	ATP binding site [chemical binding]; other site
767029007054	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029007055	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029007056	Transcriptional regulators [Transcription]; Region: MarR; COG1846
767029007057	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
767029007058	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
767029007059	hypothetical protein; Provisional; Region: PRK02237
767029007060	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
767029007061	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
767029007062	NAD(P) binding site [chemical binding]; other site
767029007063	active site
767029007064	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
767029007065	Histidine kinase; Region: HisKA_3; pfam07730
767029007066	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029007067	ATP binding site [chemical binding]; other site
767029007068	Mg2+ binding site [ion binding]; other site
767029007069	G-X-G motif; other site
767029007070	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029007071	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029007072	active site
767029007073	phosphorylation site [posttranslational modification]
767029007074	intermolecular recognition site; other site
767029007075	dimerization interface [polypeptide binding]; other site
767029007076	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029007077	DNA binding residues [nucleotide binding]
767029007078	dimerization interface [polypeptide binding]; other site
767029007079	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
767029007080	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
767029007081	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
767029007082	Walker A/P-loop; other site
767029007083	ATP binding site [chemical binding]; other site
767029007084	Q-loop/lid; other site
767029007085	ABC transporter signature motif; other site
767029007086	Walker B; other site
767029007087	D-loop; other site
767029007088	H-loop/switch region; other site
767029007089	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
767029007090	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
767029007091	Walker A/P-loop; other site
767029007092	ATP binding site [chemical binding]; other site
767029007093	Q-loop/lid; other site
767029007094	ABC transporter signature motif; other site
767029007095	Walker B; other site
767029007096	D-loop; other site
767029007097	H-loop/switch region; other site
767029007098	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
767029007099	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
767029007100	recombination factor protein RarA; Reviewed; Region: PRK13342
767029007101	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
767029007102	Walker A motif; other site
767029007103	ATP binding site [chemical binding]; other site
767029007104	Walker B motif; other site
767029007105	arginine finger; other site
767029007106	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
767029007107	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
767029007108	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
767029007109	non-specific DNA binding site [nucleotide binding]; other site
767029007110	salt bridge; other site
767029007111	sequence-specific DNA binding site [nucleotide binding]; other site
767029007112	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
767029007113	active site
767029007114	NTP binding site [chemical binding]; other site
767029007115	metal binding triad [ion binding]; metal-binding site
767029007116	antibiotic binding site [chemical binding]; other site
767029007117	recombination protein RecR; Reviewed; Region: recR; PRK00076
767029007118	RecR protein; Region: RecR; pfam02132
767029007119	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
767029007120	putative active site [active]
767029007121	putative metal-binding site [ion binding]; other site
767029007122	tetramer interface [polypeptide binding]; other site
767029007123	hypothetical protein; Validated; Region: PRK00153
767029007124	Predicted permease [General function prediction only]; Region: COG2056
767029007125	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
767029007126	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
767029007127	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
767029007128	catalytic residue [active]
767029007129	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
767029007130	metal ion-dependent adhesion site (MIDAS); other site
767029007131	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
767029007132	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
767029007133	PAS fold; Region: PAS_3; pfam08447
767029007134	putative active site [active]
767029007135	heme pocket [chemical binding]; other site
767029007136	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
767029007137	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
767029007138	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029007139	putative substrate translocation pore; other site
767029007140	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029007141	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
767029007142	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
767029007143	putative substrate binding site [chemical binding]; other site
767029007144	putative ATP binding site [chemical binding]; other site
767029007145	FOG: WD40 repeat [General function prediction only]; Region: COG2319
767029007146	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
767029007147	structural tetrad; other site
767029007148	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
767029007149	Coenzyme A binding pocket [chemical binding]; other site
767029007150	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
767029007151	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
767029007152	S-adenosylmethionine binding site [chemical binding]; other site
767029007153	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
767029007154	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
767029007155	protein binding site [polypeptide binding]; other site
767029007156	Predicted ATPase [General function prediction only]; Region: COG4637
767029007157	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029007158	Walker A/P-loop; other site
767029007159	ATP binding site [chemical binding]; other site
767029007160	phosphoserine phosphatase SerB; Region: serB; TIGR00338
767029007161	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
767029007162	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
767029007163	motif II; other site
767029007164	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
767029007165	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
767029007166	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
767029007167	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
767029007168	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
767029007169	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
767029007170	metal binding site [ion binding]; metal-binding site
767029007171	dimer interface [polypeptide binding]; other site
767029007172	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
767029007173	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
767029007174	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029007175	dimer interface [polypeptide binding]; other site
767029007176	conserved gate region; other site
767029007177	ABC-ATPase subunit interface; other site
767029007178	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
767029007179	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
767029007180	Walker A/P-loop; other site
767029007181	ATP binding site [chemical binding]; other site
767029007182	Q-loop/lid; other site
767029007183	ABC transporter signature motif; other site
767029007184	Walker B; other site
767029007185	D-loop; other site
767029007186	H-loop/switch region; other site
767029007187	NIL domain; Region: NIL; pfam09383
767029007188	PemK-like protein; Region: PemK; pfam02452
767029007189	Class I aldolases; Region: Aldolase_Class_I; cl17187
767029007190	catalytic residue [active]
767029007191	Bacterial SH3 domain; Region: SH3_3; pfam08239
767029007192	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
767029007193	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
767029007194	MOSC domain; Region: MOSC; pfam03473
767029007195	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
767029007196	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
767029007197	active site
767029007198	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
767029007199	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
767029007200	active site
767029007201	dimer interface [polypeptide binding]; other site
767029007202	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
767029007203	dimer interface [polypeptide binding]; other site
767029007204	active site
767029007205	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
767029007206	putative active site [active]
767029007207	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
767029007208	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
767029007209	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
767029007210	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
767029007211	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
767029007212	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
767029007213	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
767029007214	dimerization interface [polypeptide binding]; other site
767029007215	putative ATP binding site [chemical binding]; other site
767029007216	amidophosphoribosyltransferase; Provisional; Region: PRK07847
767029007217	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
767029007218	active site
767029007219	tetramer interface [polypeptide binding]; other site
767029007220	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
767029007221	active site
767029007222	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
767029007223	putative active site [active]
767029007224	hypothetical protein; Provisional; Region: PRK07907
767029007225	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
767029007226	active site
767029007227	metal binding site [ion binding]; metal-binding site
767029007228	dimer interface [polypeptide binding]; other site
767029007229	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
767029007230	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029007231	dimer interface [polypeptide binding]; other site
767029007232	conserved gate region; other site
767029007233	ABC-ATPase subunit interface; other site
767029007234	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029007235	dimer interface [polypeptide binding]; other site
767029007236	conserved gate region; other site
767029007237	putative PBP binding loops; other site
767029007238	ABC-ATPase subunit interface; other site
767029007239	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
767029007240	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
767029007241	Transcriptional regulators [Transcription]; Region: PurR; COG1609
767029007242	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
767029007243	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
767029007244	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
767029007245	active site
767029007246	catalytic site [active]
767029007247	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
767029007248	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
767029007249	DNA binding residues [nucleotide binding]
767029007250	putative dimer interface [polypeptide binding]; other site
767029007251	chaperone protein DnaJ; Provisional; Region: PRK14295
767029007252	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
767029007253	HSP70 interaction site [polypeptide binding]; other site
767029007254	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
767029007255	Zn binding sites [ion binding]; other site
767029007256	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
767029007257	dimer interface [polypeptide binding]; other site
767029007258	GrpE; Region: GrpE; pfam01025
767029007259	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
767029007260	dimer interface [polypeptide binding]; other site
767029007261	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
767029007262	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
767029007263	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
767029007264	nucleotide binding site [chemical binding]; other site
767029007265	NEF interaction site [polypeptide binding]; other site
767029007266	SBD interface [polypeptide binding]; other site
767029007267	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
767029007268	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413
767029007269	active site
767029007270	catalytic residues [active]
767029007271	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
767029007272	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
767029007273	non-specific DNA binding site [nucleotide binding]; other site
767029007274	salt bridge; other site
767029007275	sequence-specific DNA binding site [nucleotide binding]; other site
767029007276	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
767029007277	active site
767029007278	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
767029007279	putative dimer interface [polypeptide binding]; other site
767029007280	catalytic triad [active]
767029007281	Uncharacterized conserved protein [Function unknown]; Region: COG4748
767029007282	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
767029007283	Putative amidase domain; Region: Amidase_6; pfam12671
767029007284	Replication-relaxation; Region: Replic_Relax; pfam13814
767029007285	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
767029007286	AAA-like domain; Region: AAA_10; pfam12846
767029007287	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
767029007288	Walker B motif; other site
767029007289	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
767029007290	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
767029007291	non-specific DNA binding site [nucleotide binding]; other site
767029007292	salt bridge; other site
767029007293	sequence-specific DNA binding site [nucleotide binding]; other site
767029007294	Virulence protein [General function prediction only]; Region: COG3943
767029007295	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
767029007296	Divergent AAA domain; Region: AAA_4; pfam04326
767029007297	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
767029007298	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
767029007299	dimer interface [polypeptide binding]; other site
767029007300	putative functional site; other site
767029007301	putative MPT binding site; other site
767029007302	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
767029007303	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
767029007304	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
767029007305	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
767029007306	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
767029007307	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
767029007308	Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542
767029007309	Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897
767029007310	active site
767029007311	substrate binding site; other site
767029007312	hypothetical protein; Provisional; Region: PRK06547
767029007313	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
767029007314	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
767029007315	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029007316	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029007317	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
767029007318	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
767029007319	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
767029007320	malate dehydrogenase; Provisional; Region: PRK13529
767029007321	Malic enzyme, N-terminal domain; Region: malic; pfam00390
767029007322	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
767029007323	NAD(P) binding pocket [chemical binding]; other site
767029007324	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
767029007325	SdpI/YhfL protein family; Region: SdpI; pfam13630
767029007326	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
767029007327	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029007328	putative substrate translocation pore; other site
767029007329	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029007330	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029007331	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029007332	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
767029007333	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
767029007334	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
767029007335	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
767029007336	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
767029007337	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
767029007338	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
767029007339	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
767029007340	AAA domain; Region: AAA_14; pfam13173
767029007341	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
767029007342	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
767029007343	Coenzyme A binding pocket [chemical binding]; other site
767029007344	ambiguous bases; SNP confirmed by PCR
767029007345	DinB superfamily; Region: DinB_2; pfam12867
767029007346	DinB family; Region: DinB; cl17821
767029007347	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
767029007348	ribonuclease Z; Region: RNase_Z; TIGR02651
767029007349	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
767029007350	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
767029007351	Proline dehydrogenase; Region: Pro_dh; cl03282
767029007352	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
767029007353	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
767029007354	NAD(P) binding site [chemical binding]; other site
767029007355	catalytic residues [active]
767029007356	Uncharacterized conserved protein [Function unknown]; Region: COG1359
767029007357	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
767029007358	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029007359	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029007360	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029007361	putative substrate translocation pore; other site
767029007362	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029007363	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
767029007364	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
767029007365	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
767029007366	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
767029007367	Coenzyme A binding pocket [chemical binding]; other site
767029007368	SnoaL-like domain; Region: SnoaL_2; pfam12680
767029007369	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
767029007370	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
767029007371	Coenzyme A binding pocket [chemical binding]; other site
767029007372	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
767029007373	S-adenosylmethionine binding site [chemical binding]; other site
767029007374	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
767029007375	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
767029007376	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
767029007377	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029007378	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029007379	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
767029007380	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029007381	Major Facilitator Superfamily; Region: MFS_1; pfam07690
767029007382	putative substrate translocation pore; other site
767029007383	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
767029007384	NmrA-like family; Region: NmrA; pfam05368
767029007385	NADP binding site [chemical binding]; other site
767029007386	active site
767029007387	regulatory binding site [polypeptide binding]; other site
767029007388	Predicted transcriptional regulators [Transcription]; Region: COG1733
767029007389	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
767029007390	putative Zn2+ binding site [ion binding]; other site
767029007391	putative DNA binding site [nucleotide binding]; other site
767029007392	Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827
767029007393	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
767029007394	putative active site [active]
767029007395	AAA ATPase domain; Region: AAA_16; pfam13191
767029007396	AAA domain; Region: AAA_22; pfam13401
767029007397	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
767029007398	Coenzyme A binding pocket [chemical binding]; other site
767029007399	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
767029007400	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
767029007401	sequence-specific DNA binding site [nucleotide binding]; other site
767029007402	salt bridge; other site
767029007403	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
767029007404	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
767029007405	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
767029007406	non-specific DNA binding site [nucleotide binding]; other site
767029007407	salt bridge; other site
767029007408	sequence-specific DNA binding site [nucleotide binding]; other site
767029007409	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
767029007410	DDE superfamily endonuclease; Region: DDE_4; pfam13359
767029007411	SacI restriction endonuclease; Region: RE_SacI; pfam09566
767029007412	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
767029007413	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
767029007414	cofactor binding site; other site
767029007415	DNA binding site [nucleotide binding]
767029007416	substrate interaction site [chemical binding]; other site
767029007417	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
767029007418	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
767029007419	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
767029007420	catalytic residues [active]
767029007421	catalytic nucleophile [active]
767029007422	Recombinase; Region: Recombinase; pfam07508
767029007423	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
767029007424	GTP-binding protein YchF; Reviewed; Region: PRK09601
767029007425	YchF GTPase; Region: YchF; cd01900
767029007426	G1 box; other site
767029007427	GTP/Mg2+ binding site [chemical binding]; other site
767029007428	Switch I region; other site
767029007429	G2 box; other site
767029007430	Switch II region; other site
767029007431	G3 box; other site
767029007432	G4 box; other site
767029007433	G5 box; other site
767029007434	Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071
767029007435	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
767029007436	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
767029007437	active site
767029007438	metal binding site [ion binding]; metal-binding site
767029007439	RmuC family; Region: RmuC; pfam02646
767029007440	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
767029007441	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
767029007442	threonine dehydratase; Validated; Region: PRK08639
767029007443	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
767029007444	tetramer interface [polypeptide binding]; other site
767029007445	pyridoxal 5'-phosphate binding site [chemical binding]; other site
767029007446	catalytic residue [active]
767029007447	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
767029007448	Protein of unknown function (DUF2185); Region: DUF2185; cl02019
767029007449	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
767029007450	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
767029007451	YwiC-like protein; Region: YwiC; pfam14256
767029007452	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
767029007453	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
767029007454	generic binding surface II; other site
767029007455	generic binding surface I; other site
767029007456	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
767029007457	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
767029007458	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
767029007459	catalytic residue [active]
767029007460	putative FPP diphosphate  binding site; other site
767029007461	putative FPP binding hydrophobic cleft; other site
767029007462	dimer interface [polypeptide binding]; other site
767029007463	putative IPP diphosphate binding site; other site
767029007464	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
767029007465	TAP-like protein; Region: Abhydrolase_4; pfam08386
767029007466	PSP1 C-terminal conserved region; Region: PSP1; cl00770
767029007467	DNA polymerase III subunit delta'; Validated; Region: PRK07940
767029007468	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
767029007469	DNA polymerase III subunit delta'; Validated; Region: PRK08485
767029007470	thymidylate kinase; Validated; Region: tmk; PRK00698
767029007471	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
767029007472	TMP-binding site; other site
767029007473	ATP-binding site [chemical binding]; other site
767029007474	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
767029007475	putative active site; other site
767029007476	putative triphosphate binding site [ion binding]; other site
767029007477	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
767029007478	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
767029007479	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
767029007480	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
767029007481	NADH(P)-binding; Region: NAD_binding_10; pfam13460
767029007482	NAD(P) binding site [chemical binding]; other site
767029007483	active site
767029007484	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
767029007485	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
767029007486	active site
767029007487	interdomain interaction site; other site
767029007488	putative metal-binding site [ion binding]; other site
767029007489	nucleotide binding site [chemical binding]; other site
767029007490	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
767029007491	domain I; other site
767029007492	phosphate binding site [ion binding]; other site
767029007493	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
767029007494	domain II; other site
767029007495	domain III; other site
767029007496	nucleotide binding site [chemical binding]; other site
767029007497	DNA binding groove [nucleotide binding]
767029007498	catalytic site [active]
767029007499	domain IV; other site
767029007500	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
767029007501	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
767029007502	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
767029007503	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029007504	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029007505	myosin-cross-reactive antigen; Provisional; Region: PRK13977
767029007506	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
767029007507	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
767029007508	nucleotide binding site [chemical binding]; other site
767029007509	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
767029007510	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
767029007511	Sodium Bile acid symporter family; Region: SBF; cl17470
767029007512	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
767029007513	Phosphotransferase enzyme family; Region: APH; pfam01636
767029007514	active site
767029007515	substrate binding site [chemical binding]; other site
767029007516	ATP binding site [chemical binding]; other site
767029007517	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
767029007518	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
767029007519	active site
767029007520	substrate binding [chemical binding]; other site
767029007521	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
767029007522	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
767029007523	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
767029007524	Walker A/P-loop; other site
767029007525	ATP binding site [chemical binding]; other site
767029007526	Q-loop/lid; other site
767029007527	ABC transporter signature motif; other site
767029007528	Walker B; other site
767029007529	D-loop; other site
767029007530	H-loop/switch region; other site
767029007531	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
767029007532	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
767029007533	FtsX-like permease family; Region: FtsX; pfam02687
767029007534	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
767029007535	arginine-tRNA ligase; Region: PLN02286
767029007536	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
767029007537	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
767029007538	active site
767029007539	HIGH motif; other site
767029007540	KMSK motif region; other site
767029007541	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
767029007542	tRNA binding surface [nucleotide binding]; other site
767029007543	anticodon binding site; other site
767029007544	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
767029007545	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
767029007546	active site
767029007547	catalytic tetrad [active]
767029007548	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
767029007549	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
767029007550	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
767029007551	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
767029007552	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
767029007553	IHF dimer interface [polypeptide binding]; other site
767029007554	IHF - DNA interface [nucleotide binding]; other site
767029007555	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
767029007556	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
767029007557	Ligand binding site; other site
767029007558	Putative Catalytic site; other site
767029007559	DXD motif; other site
767029007560	GtrA-like protein; Region: GtrA; pfam04138
767029007561	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
767029007562	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
767029007563	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
767029007564	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
767029007565	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
767029007566	inhibitor-cofactor binding pocket; inhibition site
767029007567	pyridoxal 5'-phosphate binding site [chemical binding]; other site
767029007568	catalytic residue [active]
767029007569	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
767029007570	putative CoA binding site [chemical binding]; other site
767029007571	putative trimer interface [polypeptide binding]; other site
767029007572	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
767029007573	putative trimer interface [polypeptide binding]; other site
767029007574	putative active site [active]
767029007575	putative substrate binding site [chemical binding]; other site
767029007576	putative CoA binding site [chemical binding]; other site
767029007577	membrane ATPase/protein kinase; Provisional; Region: PRK09435
767029007578	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
767029007579	Walker A; other site
767029007580	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
767029007581	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
767029007582	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
767029007583	phosphopeptide binding site; other site
767029007584	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
767029007585	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
767029007586	phosphopeptide binding site; other site
767029007587	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
767029007588	active site
767029007589	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
767029007590	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
767029007591	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
767029007592	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
767029007593	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
767029007594	active site
767029007595	ATP binding site [chemical binding]; other site
767029007596	substrate binding site [chemical binding]; other site
767029007597	activation loop (A-loop); other site
767029007598	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
767029007599	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
767029007600	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
767029007601	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
767029007602	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
767029007603	Glutamine amidotransferase class-I; Region: GATase; pfam00117
767029007604	glutamine binding [chemical binding]; other site
767029007605	catalytic triad [active]
767029007606	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
767029007607	Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506
767029007608	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
767029007609	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
767029007610	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
767029007611	dimer interface [polypeptide binding]; other site
767029007612	putative anticodon binding site; other site
767029007613	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
767029007614	motif 1; other site
767029007615	dimer interface [polypeptide binding]; other site
767029007616	active site
767029007617	motif 2; other site
767029007618	motif 3; other site
767029007619	Domain of unknown function (DUF4213); Region: DUF4213; pfam13938
767029007620	Domain of unknown function (DUF364); Region: DUF364; pfam04016
767029007621	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
767029007622	dimerization interface [polypeptide binding]; other site
767029007623	putative DNA binding site [nucleotide binding]; other site
767029007624	putative Zn2+ binding site [ion binding]; other site
767029007625	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
767029007626	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
767029007627	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
767029007628	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
767029007629	CRISPR/Cas system-associated protein Csx17; Region: Csx17_I-U; cd09767
767029007630	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
767029007631	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
767029007632	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
767029007633	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
767029007634	iron-sulfur cluster [ion binding]; other site
767029007635	[2Fe-2S] cluster binding site [ion binding]; other site
767029007636	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
767029007637	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029007638	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029007639	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
767029007640	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
767029007641	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029007642	Walker A/P-loop; other site
767029007643	ATP binding site [chemical binding]; other site
767029007644	Q-loop/lid; other site
767029007645	ABC transporter signature motif; other site
767029007646	Walker B; other site
767029007647	D-loop; other site
767029007648	H-loop/switch region; other site
767029007649	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
767029007650	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
767029007651	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
767029007652	Walker A/P-loop; other site
767029007653	ATP binding site [chemical binding]; other site
767029007654	Q-loop/lid; other site
767029007655	ABC transporter signature motif; other site
767029007656	Walker B; other site
767029007657	D-loop; other site
767029007658	H-loop/switch region; other site
767029007659	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
767029007660	potassium/proton antiporter; Reviewed; Region: PRK05326
767029007661	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
767029007662	TrkA-C domain; Region: TrkA_C; pfam02080
767029007663	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
767029007664	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
767029007665	putative ADP-binding pocket [chemical binding]; other site
767029007666	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
767029007667	Helix-turn-helix domain; Region: HTH_28; pfam13518
767029007668	Winged helix-turn helix; Region: HTH_29; pfam13551
767029007669	Homeodomain-like domain; Region: HTH_32; pfam13565
767029007670	DDE superfamily endonuclease; Region: DDE_3; pfam13358
767029007671	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
767029007672	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
767029007673	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
767029007674	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
767029007675	Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183
767029007676	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
767029007677	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
767029007678	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
767029007679	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
767029007680	dimer interface [polypeptide binding]; other site
767029007681	substrate binding site [chemical binding]; other site
767029007682	metal binding sites [ion binding]; metal-binding site
767029007683	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
767029007684	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029007685	Walker A/P-loop; other site
767029007686	ATP binding site [chemical binding]; other site
767029007687	Q-loop/lid; other site
767029007688	ABC transporter signature motif; other site
767029007689	Walker B; other site
767029007690	D-loop; other site
767029007691	H-loop/switch region; other site
767029007692	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
767029007693	ABC-2 type transporter; Region: ABC2_membrane; cl17235
767029007694	ABC-2 type transporter; Region: ABC2_membrane; cl17235
767029007695	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
767029007696	Methyltransferase domain; Region: Methyltransf_26; pfam13659
767029007697	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
767029007698	catalytic core [active]
767029007699	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
767029007700	Protein of unknown function (DUF541); Region: SIMPL; cl01077
767029007701	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
767029007702	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
767029007703	Walker A/P-loop; other site
767029007704	ATP binding site [chemical binding]; other site
767029007705	Q-loop/lid; other site
767029007706	ABC transporter signature motif; other site
767029007707	Walker B; other site
767029007708	D-loop; other site
767029007709	H-loop/switch region; other site
767029007710	Transcriptional regulators [Transcription]; Region: PurR; COG1609
767029007711	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
767029007712	DNA binding site [nucleotide binding]
767029007713	domain linker motif; other site
767029007714	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
767029007715	ligand binding site [chemical binding]; other site
767029007716	dimerization interface (open form) [polypeptide binding]; other site
767029007717	dimerization interface (closed form) [polypeptide binding]; other site
767029007718	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
767029007719	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
767029007720	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
767029007721	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
767029007722	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
767029007723	MFS/sugar transport protein; Region: MFS_2; pfam13347
767029007724	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
767029007725	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
767029007726	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
767029007727	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
767029007728	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
767029007729	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
767029007730	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
767029007731	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
767029007732	pyridoxal 5'-phosphate binding site [chemical binding]; other site
767029007733	catalytic residue [active]
767029007734	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029007735	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
767029007736	Walker A/P-loop; other site
767029007737	ATP binding site [chemical binding]; other site
767029007738	Q-loop/lid; other site
767029007739	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
767029007740	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029007741	Walker A/P-loop; other site
767029007742	ATP binding site [chemical binding]; other site
767029007743	Q-loop/lid; other site
767029007744	ABC transporter signature motif; other site
767029007745	Walker B; other site
767029007746	D-loop; other site
767029007747	H-loop/switch region; other site
767029007748	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
767029007749	Predicted membrane protein [Function unknown]; Region: COG2259
767029007750	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
767029007751	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029007752	active site
767029007753	phosphorylation site [posttranslational modification]
767029007754	intermolecular recognition site; other site
767029007755	dimerization interface [polypeptide binding]; other site
767029007756	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
767029007757	DNA binding site [nucleotide binding]
767029007758	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
767029007759	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
767029007760	dimer interface [polypeptide binding]; other site
767029007761	phosphorylation site [posttranslational modification]
767029007762	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029007763	ATP binding site [chemical binding]; other site
767029007764	Mg2+ binding site [ion binding]; other site
767029007765	G-X-G motif; other site
767029007766	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
767029007767	intersubunit interface [polypeptide binding]; other site
767029007768	active site
767029007769	catalytic residue [active]
767029007770	thiazolinyl imide reductase; Region: thiaz-red; TIGR01761
767029007771	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
767029007772	NADH(P)-binding; Region: NAD_binding_10; pfam13460
767029007773	Phosphopantetheine attachment site; Region: PP-binding; cl09936
767029007774	Condensation domain; Region: Condensation; pfam00668
767029007775	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
767029007776	Nonribosomal peptide synthase; Region: NRPS; pfam08415
767029007777	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
767029007778	acyl-activating enzyme (AAE) consensus motif; other site
767029007779	AMP binding site [chemical binding]; other site
767029007780	Condensation domain; Region: Condensation; pfam00668
767029007781	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
767029007782	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
767029007783	acyl-activating enzyme (AAE) consensus motif; other site
767029007784	AMP binding site [chemical binding]; other site
767029007785	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
767029007786	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
767029007787	Condensation domain; Region: Condensation; pfam00668
767029007788	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
767029007789	Nonribosomal peptide synthase; Region: NRPS; pfam08415
767029007790	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
767029007791	acyl-activating enzyme (AAE) consensus motif; other site
767029007792	AMP binding site [chemical binding]; other site
767029007793	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
767029007794	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
767029007795	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
767029007796	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
767029007797	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
767029007798	acyl-activating enzyme (AAE) consensus motif; other site
767029007799	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
767029007800	AMP binding site [chemical binding]; other site
767029007801	active site
767029007802	acyl-activating enzyme (AAE) consensus motif; other site
767029007803	CoA binding site [chemical binding]; other site
767029007804	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
767029007805	ABC-2 type transporter; Region: ABC2_membrane; cl17235
767029007806	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
767029007807	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029007808	Walker A/P-loop; other site
767029007809	ATP binding site [chemical binding]; other site
767029007810	Q-loop/lid; other site
767029007811	ABC transporter signature motif; other site
767029007812	Walker B; other site
767029007813	D-loop; other site
767029007814	H-loop/switch region; other site
767029007815	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
767029007816	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
767029007817	Condensation domain; Region: Condensation; pfam00668
767029007818	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
767029007819	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
767029007820	Thioesterase domain; Region: Thioesterase; pfam00975
767029007821	Condensation domain; Region: Condensation; pfam00668
767029007822	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
767029007823	Nonribosomal peptide synthase; Region: NRPS; pfam08415
767029007824	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
767029007825	acyl-activating enzyme (AAE) consensus motif; other site
767029007826	AMP binding site [chemical binding]; other site
767029007827	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
767029007828	Uncharacterized conserved protein [Function unknown]; Region: COG3268
767029007829	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
767029007830	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
767029007831	Walker A/P-loop; other site
767029007832	ATP binding site [chemical binding]; other site
767029007833	Q-loop/lid; other site
767029007834	ABC transporter signature motif; other site
767029007835	Walker B; other site
767029007836	D-loop; other site
767029007837	H-loop/switch region; other site
767029007838	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029007839	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
767029007840	Walker A/P-loop; other site
767029007841	ATP binding site [chemical binding]; other site
767029007842	Q-loop/lid; other site
767029007843	ABC transporter signature motif; other site
767029007844	Walker B; other site
767029007845	D-loop; other site
767029007846	H-loop/switch region; other site
767029007847	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
767029007848	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
767029007849	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
767029007850	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
767029007851	acyl-activating enzyme (AAE) consensus motif; other site
767029007852	active site
767029007853	CoA binding site [chemical binding]; other site
767029007854	AMP binding site [chemical binding]; other site
767029007855	Phosphopantetheine attachment site; Region: PP-binding; cl09936
767029007856	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
767029007857	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
767029007858	acyl-activating enzyme (AAE) consensus motif; other site
767029007859	AMP binding site [chemical binding]; other site
767029007860	active site
767029007861	CoA binding site [chemical binding]; other site
767029007862	benzoate transport; Region: 2A0115; TIGR00895
767029007863	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029007864	putative substrate translocation pore; other site
767029007865	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
767029007866	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
767029007867	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
767029007868	Walker A/P-loop; other site
767029007869	ATP binding site [chemical binding]; other site
767029007870	Q-loop/lid; other site
767029007871	ABC transporter signature motif; other site
767029007872	Walker B; other site
767029007873	D-loop; other site
767029007874	H-loop/switch region; other site
767029007875	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
767029007876	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029007877	Walker A/P-loop; other site
767029007878	ATP binding site [chemical binding]; other site
767029007879	Q-loop/lid; other site
767029007880	ABC transporter signature motif; other site
767029007881	Walker B; other site
767029007882	D-loop; other site
767029007883	H-loop/switch region; other site
767029007884	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
767029007885	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
767029007886	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
767029007887	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029007888	Walker A/P-loop; other site
767029007889	ATP binding site [chemical binding]; other site
767029007890	Q-loop/lid; other site
767029007891	ABC transporter signature motif; other site
767029007892	Walker B; other site
767029007893	D-loop; other site
767029007894	H-loop/switch region; other site
767029007895	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
767029007896	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
767029007897	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029007898	Walker A/P-loop; other site
767029007899	ATP binding site [chemical binding]; other site
767029007900	Q-loop/lid; other site
767029007901	ABC transporter signature motif; other site
767029007902	Walker B; other site
767029007903	D-loop; other site
767029007904	H-loop/switch region; other site
767029007905	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
767029007906	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
767029007907	Predicted ATPases [General function prediction only]; Region: COG1106
767029007908	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029007909	Walker B; other site
767029007910	D-loop; other site
767029007911	H-loop/switch region; other site
767029007912	RloB-like protein; Region: RloB; pfam13707
767029007913	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
767029007914	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029007915	Walker A/P-loop; other site
767029007916	ATP binding site [chemical binding]; other site
767029007917	Q-loop/lid; other site
767029007918	ABC transporter signature motif; other site
767029007919	Walker B; other site
767029007920	D-loop; other site
767029007921	H-loop/switch region; other site
767029007922	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
767029007923	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
767029007924	Coenzyme A binding pocket [chemical binding]; other site
767029007925	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
767029007926	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
767029007927	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029007928	Walker A/P-loop; other site
767029007929	ATP binding site [chemical binding]; other site
767029007930	Q-loop/lid; other site
767029007931	ABC transporter signature motif; other site
767029007932	Walker B; other site
767029007933	D-loop; other site
767029007934	H-loop/switch region; other site
767029007935	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
767029007936	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029007937	AAA domain; Region: AAA_21; pfam13304
767029007938	Walker A/P-loop; other site
767029007939	ATP binding site [chemical binding]; other site
767029007940	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029007941	ABC transporter signature motif; other site
767029007942	Walker B; other site
767029007943	D-loop; other site
767029007944	H-loop/switch region; other site
767029007945	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
767029007946	trimer interface [polypeptide binding]; other site
767029007947	active site
767029007948	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
767029007949	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
767029007950	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
767029007951	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
767029007952	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
767029007953	putative DNA binding site [nucleotide binding]; other site
767029007954	putative Zn2+ binding site [ion binding]; other site
767029007955	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
767029007956	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
767029007957	nucleotide binding site [chemical binding]; other site
767029007958	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
767029007959	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
767029007960	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
767029007961	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
767029007962	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029007963	dimer interface [polypeptide binding]; other site
767029007964	conserved gate region; other site
767029007965	putative PBP binding loops; other site
767029007966	ABC-ATPase subunit interface; other site
767029007967	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
767029007968	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029007969	dimer interface [polypeptide binding]; other site
767029007970	conserved gate region; other site
767029007971	putative PBP binding loops; other site
767029007972	ABC-ATPase subunit interface; other site
767029007973	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
767029007974	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
767029007975	Walker A/P-loop; other site
767029007976	ATP binding site [chemical binding]; other site
767029007977	Q-loop/lid; other site
767029007978	ABC transporter signature motif; other site
767029007979	Walker B; other site
767029007980	D-loop; other site
767029007981	H-loop/switch region; other site
767029007982	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
767029007983	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
767029007984	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
767029007985	Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060
767029007986	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
767029007987	active site
767029007988	HIGH motif; other site
767029007989	nucleotide binding site [chemical binding]; other site
767029007990	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
767029007991	active site
767029007992	KMSKS motif; other site
767029007993	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
767029007994	tRNA binding surface [nucleotide binding]; other site
767029007995	anticodon binding site; other site
767029007996	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
767029007997	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
767029007998	pyridoxal 5'-phosphate binding site [chemical binding]; other site
767029007999	homodimer interface [polypeptide binding]; other site
767029008000	catalytic residue [active]
767029008001	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
767029008002	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
767029008003	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
767029008004	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
767029008005	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
767029008006	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029008007	ATP binding site [chemical binding]; other site
767029008008	Mg2+ binding site [ion binding]; other site
767029008009	G-X-G motif; other site
767029008010	Response regulator receiver domain; Region: Response_reg; pfam00072
767029008011	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029008012	active site
767029008013	phosphorylation site [posttranslational modification]
767029008014	intermolecular recognition site; other site
767029008015	dimerization interface [polypeptide binding]; other site
767029008016	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
767029008017	DNA binding residues [nucleotide binding]
767029008018	dimerization interface [polypeptide binding]; other site
767029008019	aspartate kinase; Reviewed; Region: PRK06635
767029008020	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
767029008021	putative nucleotide binding site [chemical binding]; other site
767029008022	putative catalytic residues [active]
767029008023	putative Mg ion binding site [ion binding]; other site
767029008024	putative aspartate binding site [chemical binding]; other site
767029008025	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
767029008026	putative allosteric regulatory site; other site
767029008027	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
767029008028	putative allosteric regulatory residue; other site
767029008029	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029008030	Walker A/P-loop; other site
767029008031	ATP binding site [chemical binding]; other site
767029008032	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
767029008033	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
767029008034	Walker A/P-loop; other site
767029008035	ATP binding site [chemical binding]; other site
767029008036	Q-loop/lid; other site
767029008037	ABC transporter signature motif; other site
767029008038	Walker B; other site
767029008039	D-loop; other site
767029008040	H-loop/switch region; other site
767029008041	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
767029008042	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
767029008043	ABC-ATPase subunit  interface; other site
767029008044	dimer interface [polypeptide binding]; other site
767029008045	putative PBP binding regions; other site
767029008046	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
767029008047	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
767029008048	intersubunit interface [polypeptide binding]; other site
767029008049	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
767029008050	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
767029008051	intersubunit interface [polypeptide binding]; other site
767029008052	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
767029008053	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
767029008054	ABC-ATPase subunit  interface; other site
767029008055	dimer interface [polypeptide binding]; other site
767029008056	putative PBP binding regions; other site
767029008057	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
767029008058	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
767029008059	Walker A/P-loop; other site
767029008060	ATP binding site [chemical binding]; other site
767029008061	Q-loop/lid; other site
767029008062	ABC transporter signature motif; other site
767029008063	Walker B; other site
767029008064	D-loop; other site
767029008065	H-loop/switch region; other site
767029008066	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029008067	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
767029008068	Walker A/P-loop; other site
767029008069	ATP binding site [chemical binding]; other site
767029008070	Q-loop/lid; other site
767029008071	ABC transporter signature motif; other site
767029008072	Walker B; other site
767029008073	D-loop; other site
767029008074	H-loop/switch region; other site
767029008075	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
767029008076	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
767029008077	FtsX-like permease family; Region: FtsX; pfam02687
767029008078	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
767029008079	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
767029008080	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
767029008081	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029008082	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029008083	active site
767029008084	phosphorylation site [posttranslational modification]
767029008085	intermolecular recognition site; other site
767029008086	dimerization interface [polypeptide binding]; other site
767029008087	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029008088	DNA binding residues [nucleotide binding]
767029008089	dimerization interface [polypeptide binding]; other site
767029008090	Histidine kinase; Region: HisKA_3; pfam07730
767029008091	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
767029008092	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
767029008093	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
767029008094	Walker A/P-loop; other site
767029008095	ATP binding site [chemical binding]; other site
767029008096	Q-loop/lid; other site
767029008097	ABC transporter signature motif; other site
767029008098	Walker B; other site
767029008099	D-loop; other site
767029008100	H-loop/switch region; other site
767029008101	Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706
767029008102	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029008103	AAA domain; Region: AAA_21; pfam13304
767029008104	Walker A/P-loop; other site
767029008105	ATP binding site [chemical binding]; other site
767029008106	AAA domain; Region: AAA_21; pfam13304
767029008107	RloB-like protein; Region: RloB; pfam13707
767029008108	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
767029008109	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
767029008110	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029008111	Walker A/P-loop; other site
767029008112	ATP binding site [chemical binding]; other site
767029008113	Q-loop/lid; other site
767029008114	ABC transporter signature motif; other site
767029008115	Walker B; other site
767029008116	D-loop; other site
767029008117	H-loop/switch region; other site
767029008118	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
767029008119	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
767029008120	Walker A/P-loop; other site
767029008121	ATP binding site [chemical binding]; other site
767029008122	Q-loop/lid; other site
767029008123	ABC transporter signature motif; other site
767029008124	Walker B; other site
767029008125	D-loop; other site
767029008126	H-loop/switch region; other site
767029008127	FecCD transport family; Region: FecCD; pfam01032
767029008128	ABC-ATPase subunit  interface; other site
767029008129	dimer interface [polypeptide binding]; other site
767029008130	putative PBP binding regions; other site
767029008131	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
767029008132	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
767029008133	ABC-ATPase subunit  interface; other site
767029008134	dimer interface [polypeptide binding]; other site
767029008135	putative PBP binding regions; other site
767029008136	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
767029008137	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
767029008138	intersubunit interface [polypeptide binding]; other site
767029008139	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
767029008140	S-adenosylmethionine binding site [chemical binding]; other site
767029008141	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
767029008142	Divergent AAA domain; Region: AAA_4; pfam04326
767029008143	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
767029008144	MarR family; Region: MarR; pfam01047
767029008145	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
767029008146	HsdM N-terminal domain; Region: HsdM_N; pfam12161
767029008147	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
767029008148	S-adenosylmethionine binding site [chemical binding]; other site
767029008149	Virulence protein [General function prediction only]; Region: COG3943
767029008150	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
767029008151	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
767029008152	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
767029008153	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
767029008154	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
767029008155	Mrr N-terminal domain; Region: Mrr_N; pfam14338
767029008156	Restriction endonuclease; Region: Mrr_cat; pfam04471
767029008157	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
767029008158	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
767029008159	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
767029008160	ATP binding site [chemical binding]; other site
767029008161	putative Mg++ binding site [ion binding]; other site
767029008162	Helix-turn-helix domain; Region: HTH_17; pfam12728
767029008163	OsmC-like protein; Region: OsmC; pfam02566
767029008164	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
767029008165	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370
767029008166	hypothetical protein; Provisional; Region: PRK02399
767029008167	Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792
767029008168	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
767029008169	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
767029008170	DNA-binding site [nucleotide binding]; DNA binding site
767029008171	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
767029008172	pyridoxal 5'-phosphate binding site [chemical binding]; other site
767029008173	homodimer interface [polypeptide binding]; other site
767029008174	catalytic residue [active]
767029008175	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
767029008176	non-specific DNA binding site [nucleotide binding]; other site
767029008177	salt bridge; other site
767029008178	sequence-specific DNA binding site [nucleotide binding]; other site
767029008179	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
767029008180	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
767029008181	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
767029008182	Walker A motif; other site
767029008183	ATP binding site [chemical binding]; other site
767029008184	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
767029008185	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
767029008186	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
767029008187	Walker A motif; other site
767029008188	ATP binding site [chemical binding]; other site
767029008189	Walker B motif; other site
767029008190	arginine finger; other site
767029008191	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
767029008192	metal ion-dependent adhesion site (MIDAS); other site
767029008193	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
767029008194	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
767029008195	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
767029008196	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
767029008197	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
767029008198	Walker A/P-loop; other site
767029008199	ATP binding site [chemical binding]; other site
767029008200	Q-loop/lid; other site
767029008201	ABC transporter signature motif; other site
767029008202	Walker B; other site
767029008203	D-loop; other site
767029008204	H-loop/switch region; other site
767029008205	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
767029008206	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
767029008207	ABC-ATPase subunit  interface; other site
767029008208	dimer interface [polypeptide binding]; other site
767029008209	putative PBP binding regions; other site
767029008210	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
767029008211	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
767029008212	intersubunit interface [polypeptide binding]; other site
767029008213	Domain of unknown function (DUF955); Region: DUF955; cl01076
767029008214	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
767029008215	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
767029008216	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
767029008217	Transcriptional regulators [Transcription]; Region: PurR; COG1609
767029008218	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
767029008219	DNA binding site [nucleotide binding]
767029008220	domain linker motif; other site
767029008221	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
767029008222	Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251
767029008223	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
767029008224	substrate binding [chemical binding]; other site
767029008225	active site
767029008226	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
767029008227	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029008228	dimer interface [polypeptide binding]; other site
767029008229	conserved gate region; other site
767029008230	putative PBP binding loops; other site
767029008231	ABC-ATPase subunit interface; other site
767029008232	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
767029008233	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
767029008234	ABC-ATPase subunit interface; other site
767029008235	putative PBP binding loops; other site
767029008236	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
767029008237	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
767029008238	Cation efflux family; Region: Cation_efflux; cl00316
767029008239	Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251
767029008240	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
767029008241	substrate binding [chemical binding]; other site
767029008242	active site
767029008243	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
767029008244	nucleoside/Zn binding site; other site
767029008245	dimer interface [polypeptide binding]; other site
767029008246	catalytic motif [active]
767029008247	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
767029008248	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
767029008249	active site
767029008250	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
767029008251	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
767029008252	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
767029008253	substrate binding site [chemical binding]; other site
767029008254	oxyanion hole (OAH) forming residues; other site
767029008255	trimer interface [polypeptide binding]; other site
767029008256	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
767029008257	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
767029008258	active site
767029008259	catalytic site [active]
767029008260	metal binding site [ion binding]; metal-binding site
767029008261	dimer interface [polypeptide binding]; other site
767029008262	Transcriptional regulator [Transcription]; Region: LytR; COG1316
767029008263	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
767029008264	active site
767029008265	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
767029008266	Helix-turn-helix domain; Region: HTH_18; pfam12833
767029008267	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
767029008268	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
767029008269	active site
767029008270	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
767029008271	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
767029008272	NAD(P) binding site [chemical binding]; other site
767029008273	argininosuccinate synthase; Validated; Region: PRK05370
767029008274	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
767029008275	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
767029008276	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
767029008277	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
767029008278	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
767029008279	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
767029008280	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
767029008281	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
767029008282	WbqC-like protein family; Region: WbqC; pfam08889
767029008283	Major Facilitator Superfamily; Region: MFS_1; pfam07690
767029008284	Major Facilitator Superfamily; Region: MFS_1; pfam07690
767029008285	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029008286	putative substrate translocation pore; other site
767029008287	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
767029008288	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
767029008289	Walker A/P-loop; other site
767029008290	ATP binding site [chemical binding]; other site
767029008291	Q-loop/lid; other site
767029008292	ABC transporter signature motif; other site
767029008293	Walker B; other site
767029008294	D-loop; other site
767029008295	H-loop/switch region; other site
767029008296	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
767029008297	Walker A/P-loop; other site
767029008298	ATP binding site [chemical binding]; other site
767029008299	Q-loop/lid; other site
767029008300	ABC transporter signature motif; other site
767029008301	Walker B; other site
767029008302	D-loop; other site
767029008303	H-loop/switch region; other site
767029008304	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
767029008305	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
767029008306	active site
767029008307	catalytic tetrad [active]
767029008308	Isochorismatase family; Region: Isochorismatase; pfam00857
767029008309	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
767029008310	catalytic triad [active]
767029008311	conserved cis-peptide bond; other site
767029008312	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
767029008313	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
767029008314	DNA binding residues [nucleotide binding]
767029008315	putative dimer interface [polypeptide binding]; other site
767029008316	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
767029008317	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
767029008318	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
767029008319	active site
767029008320	NAD binding site [chemical binding]; other site
767029008321	metal binding site [ion binding]; metal-binding site
767029008322	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
767029008323	Sensory domain found in PocR; Region: PocR; pfam10114
767029008324	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
767029008325	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
767029008326	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
767029008327	G1 box; other site
767029008328	GTP/Mg2+ binding site [chemical binding]; other site
767029008329	G2 box; other site
767029008330	Switch I region; other site
767029008331	G3 box; other site
767029008332	Switch II region; other site
767029008333	G4 box; other site
767029008334	G5 box; other site
767029008335	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
767029008336	putative hexamer interface [polypeptide binding]; other site
767029008337	putative hexagonal pore; other site
767029008338	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
767029008339	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
767029008340	Hexamer interface [polypeptide binding]; other site
767029008341	Hexagonal pore residue; other site
767029008342	propanediol utilization protein PduB; Provisional; Region: PRK15415
767029008343	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
767029008344	putative hexamer interface [polypeptide binding]; other site
767029008345	putative hexagonal pore; other site
767029008346	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
767029008347	putative hexamer interface [polypeptide binding]; other site
767029008348	putative hexagonal pore; other site
767029008349	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
767029008350	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
767029008351	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
767029008352	alpha-beta subunit interface [polypeptide binding]; other site
767029008353	alpha-gamma subunit interface [polypeptide binding]; other site
767029008354	active site
767029008355	substrate and K+ binding site; other site
767029008356	K+ binding site [ion binding]; other site
767029008357	cobalamin binding site [chemical binding]; other site
767029008358	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
767029008359	propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443
767029008360	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
767029008361	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
767029008362	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
767029008363	Hexamer interface [polypeptide binding]; other site
767029008364	Hexagonal pore residue; other site
767029008365	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
767029008366	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
767029008367	Hexamer interface [polypeptide binding]; other site
767029008368	Hexagonal pore residue; other site
767029008369	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
767029008370	Propanediol utilisation protein PduL; Region: PduL; pfam06130
767029008371	Propanediol utilisation protein PduL; Region: PduL; pfam06130
767029008372	ethanolamine utilization protein EutJ; Provisional; Region: PRK15080
767029008373	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
767029008374	nucleotide binding site [chemical binding]; other site
767029008375	Flavoprotein; Region: Flavoprotein; cl08021
767029008376	ethanolamine utilization protein; Region: eut_hyp; TIGR02536
767029008377	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
767029008378	Hexamer/Pentamer interface [polypeptide binding]; other site
767029008379	central pore; other site
767029008380	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
767029008381	Domain of unknown function (DUF336); Region: DUF336; pfam03928
767029008382	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
767029008383	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
767029008384	putative catalytic cysteine [active]
767029008385	malate dehydrogenase; Provisional; Region: PRK05442
767029008386	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
767029008387	NAD(P) binding site [chemical binding]; other site
767029008388	LDH/MDH dimer interface [polypeptide binding]; other site
767029008389	substrate binding site [chemical binding]; other site
767029008390	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
767029008391	FOG: WD40 repeat [General function prediction only]; Region: COG2319
767029008392	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
767029008393	structural tetrad; other site
767029008394	FOG: WD40 repeat [General function prediction only]; Region: COG2319
767029008395	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
767029008396	structural tetrad; other site
767029008397	AAA domain; Region: AAA_14; pfam13173
767029008398	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
767029008399	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
767029008400	Ligand binding site; other site
767029008401	Putative Catalytic site; other site
767029008402	DXD motif; other site
767029008403	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
767029008404	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
767029008405	active site
767029008406	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
767029008407	Methyltransferase domain; Region: Methyltransf_23; pfam13489
767029008408	Methyltransferase domain; Region: Methyltransf_12; pfam08242
767029008409	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
767029008410	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
767029008411	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
767029008412	active site
767029008413	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
767029008414	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
767029008415	extended (e) SDRs; Region: SDR_e; cd08946
767029008416	NAD(P) binding site [chemical binding]; other site
767029008417	active site
767029008418	substrate binding site [chemical binding]; other site
767029008419	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
767029008420	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
767029008421	Predicted membrane protein (DUF2206); Region: DUF2206; pfam09971
767029008422	Core-2/I-Branching enzyme; Region: Branch; pfam02485
767029008423	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
767029008424	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
767029008425	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
767029008426	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
767029008427	active site
767029008428	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
767029008429	active site
767029008430	catalytic residues [active]
767029008431	Restriction endonuclease [Defense mechanisms]; Region: COG3587
767029008432	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
767029008433	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
767029008434	Divergent AAA domain; Region: AAA_4; pfam04326
767029008435	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
767029008436	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
767029008437	DNA methylase; Region: N6_N4_Mtase; pfam01555
767029008438	DNA methylase; Region: N6_N4_Mtase; cl17433
767029008439	Protein of unknown function (DUF2185); Region: DUF2185; cl02019
767029008440	Herpesvirus ICP4-like protein N-terminal region; Region: Herpes_ICP4_N; cl17480
767029008441	HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410
767029008442	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
767029008443	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
767029008444	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
767029008445	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
767029008446	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
767029008447	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
767029008448	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
767029008449	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
767029008450	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
767029008451	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
767029008452	NAD-dependent deacetylase; Provisional; Region: PRK05333
767029008453	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
767029008454	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
767029008455	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
767029008456	active site
767029008457	phosphorylation site [posttranslational modification]
767029008458	intermolecular recognition site; other site
767029008459	dimerization interface [polypeptide binding]; other site
767029008460	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
767029008461	DNA binding residues [nucleotide binding]
767029008462	Putative sensor; Region: Sensor; pfam13796
767029008463	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
767029008464	Histidine kinase; Region: HisKA_3; pfam07730
767029008465	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
767029008466	ATP binding site [chemical binding]; other site
767029008467	Mg2+ binding site [ion binding]; other site
767029008468	G-X-G motif; other site
767029008469	CAAX protease self-immunity; Region: Abi; pfam02517
767029008470	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
767029008471	putative deacylase active site [active]
767029008472	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
767029008473	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
767029008474	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029008475	putative substrate translocation pore; other site
767029008476	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029008477	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029008478	phosphoenolpyruvate synthase; Validated; Region: PRK06241
767029008479	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
767029008480	catalytic residue [active]
767029008481	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
767029008482	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
767029008483	dimerization interface [polypeptide binding]; other site
767029008484	putative DNA binding site [nucleotide binding]; other site
767029008485	putative Zn2+ binding site [ion binding]; other site
767029008486	Methyltransferase domain; Region: Methyltransf_31; pfam13847
767029008487	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
767029008488	S-adenosylmethionine binding site [chemical binding]; other site
767029008489	O-Antigen ligase; Region: Wzy_C; pfam04932
767029008490	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
767029008491	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
767029008492	AAA domain; Region: AAA_31; pfam13614
767029008493	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
767029008494	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
767029008495	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
767029008496	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
767029008497	inhibitor-cofactor binding pocket; inhibition site
767029008498	pyridoxal 5'-phosphate binding site [chemical binding]; other site
767029008499	catalytic residue [active]
767029008500	Bacterial sugar transferase; Region: Bac_transf; pfam02397
767029008501	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
767029008502	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
767029008503	acyl-activating enzyme (AAE) consensus motif; other site
767029008504	AMP binding site [chemical binding]; other site
767029008505	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
767029008506	Phosphopantetheine attachment site; Region: PP-binding; cl09936
767029008507	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
767029008508	DltD central region; Region: DltD_M; pfam04918
767029008509	DltD C-terminal region; Region: DltD_C; pfam04914
767029008510	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
767029008511	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
767029008512	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
767029008513	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
767029008514	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_III; cd01996
767029008515	Ligand Binding Site [chemical binding]; other site
767029008516	imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033
767029008517	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
767029008518	phosphate binding site [ion binding]; other site
767029008519	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
767029008520	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
767029008521	putative active site [active]
767029008522	oxyanion strand; other site
767029008523	catalytic triad [active]
767029008524	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
767029008525	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
767029008526	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
767029008527	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
767029008528	NAD(P) binding site [chemical binding]; other site
767029008529	homodimer interface [polypeptide binding]; other site
767029008530	substrate binding site [chemical binding]; other site
767029008531	active site
767029008532	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
767029008533	Na2 binding site [ion binding]; other site
767029008534	putative substrate binding site 1 [chemical binding]; other site
767029008535	Na binding site 1 [ion binding]; other site
767029008536	putative substrate binding site 2 [chemical binding]; other site
767029008537	Transglycosylase; Region: Transgly; pfam00912
767029008538	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
767029008539	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
767029008540	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
767029008541	phosphodiesterase YaeI; Provisional; Region: PRK11340
767029008542	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
767029008543	putative active site [active]
767029008544	putative metal binding site [ion binding]; other site
767029008545	Tubby C 2; Region: Tub_2; cl02043
767029008546	hypothetical protein; Provisional; Region: PRK01842
767029008547	H+ Antiporter protein; Region: 2A0121; TIGR00900
767029008548	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
767029008549	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
767029008550	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
767029008551	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
767029008552	catalytic triad [active]
767029008553	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
767029008554	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
767029008555	NlpC/P60 family; Region: NLPC_P60; cl17555
767029008556	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
767029008557	NlpC/P60 family; Region: NLPC_P60; cl17555
767029008558	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
767029008559	putative active site [active]
767029008560	nucleotide binding site [chemical binding]; other site
767029008561	nudix motif; other site
767029008562	putative metal binding site [ion binding]; other site
767029008563	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
767029008564	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
767029008565	homodimer interface [polypeptide binding]; other site
767029008566	substrate-cofactor binding pocket; other site
767029008567	catalytic residue [active]
767029008568	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
767029008569	Major Facilitator Superfamily; Region: MFS_1; pfam07690
767029008570	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029008571	putative substrate translocation pore; other site
767029008572	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
767029008573	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
767029008574	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
767029008575	active site
767029008576	Preprotein translocase subunit SecA (ATPase, RNA helicase) [Intracellular trafficking and secretion]; Region: SecA; COG0653
767029008577	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
767029008578	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
767029008579	nucleotide binding region [chemical binding]; other site
767029008580	ATP-binding site [chemical binding]; other site
767029008581	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
767029008582	MPT binding site; other site
767029008583	trimer interface [polypeptide binding]; other site
767029008584	PAC2 family; Region: PAC2; pfam09754
767029008585	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
767029008586	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029008587	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
767029008588	dimer interface [polypeptide binding]; other site
767029008589	[2Fe-2S] cluster binding site [ion binding]; other site
767029008590	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
767029008591	hydrophobic ligand binding site; other site
767029008592	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
767029008593	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
767029008594	FemAB family; Region: FemAB; pfam02388
767029008595	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
767029008596	Alanine racemase, N-terminal domain; Region: Ala_racemase_N; pfam01168
767029008597	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
767029008598	catalytic residue [active]
767029008599	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
767029008600	Transglycosylase; Region: Transgly; pfam00912
767029008601	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
767029008602	Wnt and FGF inhibitory regulator; Region: Shisa; pfam13908
767029008603	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
767029008604	Predicted transcriptional regulators [Transcription]; Region: COG1695
767029008605	Transcriptional regulator PadR-like family; Region: PadR; cl17335
767029008606	Ycf46; Provisional; Region: ycf46; CHL00195
767029008607	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
767029008608	Walker A motif; other site
767029008609	ATP binding site [chemical binding]; other site
767029008610	Walker B motif; other site
767029008611	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
767029008612	arginine finger; other site
767029008613	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
767029008614	TPR motif; other site
767029008615	Tetratricopeptide repeat; Region: TPR_12; pfam13424
767029008616	binding surface
767029008617	Tetratricopeptide repeat; Region: TPR_12; pfam13424
767029008618	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
767029008619	binding surface
767029008620	TPR motif; other site
767029008621	Tetratricopeptide repeat; Region: TPR_12; pfam13424
767029008622	Right handed beta helix region; Region: Beta_helix; pfam13229
767029008623	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
767029008624	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
767029008625	non-specific DNA binding site [nucleotide binding]; other site
767029008626	salt bridge; other site
767029008627	sequence-specific DNA binding site [nucleotide binding]; other site
767029008628	Domain of unknown function (DUF955); Region: DUF955; pfam06114
767029008629	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
767029008630	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
767029008631	putative active site [active]
767029008632	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
767029008633	AAA domain; Region: AAA_14; pfam13173
767029008634	YibE/F-like protein; Region: YibE_F; pfam07907
767029008635	Rhomboid family; Region: Rhomboid; pfam01694
767029008636	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
767029008637	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
767029008638	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
767029008639	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
767029008640	Integral membrane protein TerC family; Region: TerC; cl10468
767029008641	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
767029008642	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
767029008643	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
767029008644	NAD(P) binding site [chemical binding]; other site
767029008645	active site
767029008646	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
767029008647	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
767029008648	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
767029008649	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
767029008650	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
767029008651	Walker A/P-loop; other site
767029008652	ATP binding site [chemical binding]; other site
767029008653	Q-loop/lid; other site
767029008654	ABC transporter signature motif; other site
767029008655	Walker B; other site
767029008656	D-loop; other site
767029008657	H-loop/switch region; other site
767029008658	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
767029008659	ABC-ATPase subunit  interface; other site
767029008660	dimer interface [polypeptide binding]; other site
767029008661	putative PBP binding regions; other site
767029008662	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
767029008663	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
767029008664	ABC-ATPase subunit  interface; other site
767029008665	dimer interface [polypeptide binding]; other site
767029008666	putative PBP binding regions; other site
767029008667	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
767029008668	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
767029008669	siderophore binding site; other site
767029008670	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
767029008671	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
767029008672	dimerization interface [polypeptide binding]; other site
767029008673	DPS ferroxidase diiron center [ion binding]; other site
767029008674	ion pore; other site
767029008675	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
767029008676	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
767029008677	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
767029008678	Uncharacterized conserved protein [Function unknown]; Region: COG1434
767029008679	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
767029008680	putative active site [active]
767029008681	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
767029008682	putative substrate translocation pore; other site
767029008683	Major Facilitator Superfamily; Region: MFS_1; pfam07690
767029008684	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
767029008685	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
767029008686	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
767029008687	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
767029008688	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
767029008689	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
767029008690	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
767029008691	FeoA domain; Region: FeoA; pfam04023
767029008692	Predicted membrane protein [Function unknown]; Region: COG1971
767029008693	Domain of unknown function DUF; Region: DUF204; pfam02659
767029008694	Domain of unknown function DUF; Region: DUF204; pfam02659
767029008695	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
767029008696	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
767029008697	DNA binding residues [nucleotide binding]
767029008698	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
767029008699	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
767029008700	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
767029008701	substrate binding site [chemical binding]; other site
767029008702	oxyanion hole (OAH) forming residues; other site
767029008703	trimer interface [polypeptide binding]; other site
767029008704	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
767029008705	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
767029008706	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
767029008707	LabA_like proteins; Region: LabA_like; cd06167
767029008708	putative metal binding site [ion binding]; other site
767029008709	AzlC protein; Region: AzlC; pfam03591
767029008710	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
767029008711	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
767029008712	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
767029008713	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
767029008714	catalytic residues [active]
767029008715	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
767029008716	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
767029008717	pyridoxal 5'-phosphate binding site [chemical binding]; other site
767029008718	homodimer interface [polypeptide binding]; other site
767029008719	catalytic residue [active]
767029008720	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
767029008721	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
767029008722	ATP-grasp domain; Region: ATP-grasp_4; cl17255
767029008723	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
767029008724	ParB-like nuclease domain; Region: ParBc; pfam02195
767029008725	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
767029008726	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
767029008727	P-loop; other site
767029008728	Magnesium ion binding site [ion binding]; other site
767029008729	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
767029008730	Magnesium ion binding site [ion binding]; other site
767029008731	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
767029008732	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
767029008733	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
767029008734	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
767029008735	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
767029008736	G-X-X-G motif; other site
767029008737	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
767029008738	RxxxH motif; other site
767029008739	putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315
767029008740	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
767029008741	Haemolytic domain; Region: Haemolytic; pfam01809
767029008742	Ribonuclease P; Region: Ribonuclease_P; pfam00825