-- dump date   	20140620_001320
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
290512000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
290512000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
290512000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290512000004	Walker A motif; other site
290512000005	ATP binding site [chemical binding]; other site
290512000006	Walker B motif; other site
290512000007	arginine finger; other site
290512000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
290512000009	DnaA box-binding interface [nucleotide binding]; other site
290512000010	DNA polymerase III subunit beta; Provisional; Region: PRK14941
290512000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
290512000012	putative DNA binding surface [nucleotide binding]; other site
290512000013	dimer interface [polypeptide binding]; other site
290512000014	beta-clamp/clamp loader binding surface; other site
290512000015	beta-clamp/translesion DNA polymerase binding surface; other site
290512000016	recombination protein F; Reviewed; Region: recF; PRK00064
290512000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290512000018	Walker A/P-loop; other site
290512000019	ATP binding site [chemical binding]; other site
290512000020	Q-loop/lid; other site
290512000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290512000022	ABC transporter signature motif; other site
290512000023	Walker B; other site
290512000024	D-loop; other site
290512000025	H-loop/switch region; other site
290512000026	Protein of unknown function (DUF721); Region: DUF721; pfam05258
290512000027	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
290512000028	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
290512000029	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
290512000030	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like2_exo; cd05785
290512000031	DNA polymerase type-B family; Region: POLBc; smart00486
290512000032	active site
290512000033	catalytic site [active]
290512000034	substrate binding site [chemical binding]; other site
290512000035	DNA polymerase family B; Region: DNA_pol_B; pfam00136
290512000036	DNA polymerase type-II B subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II_B; cd05538
290512000037	active site
290512000038	metal-binding site
290512000039	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
290512000040	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
290512000041	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
290512000042	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
290512000043	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
290512000044	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
290512000045	Cytochrome c; Region: Cytochrom_C; cl11414
290512000046	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
290512000047	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
290512000048	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
290512000049	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
290512000050	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
290512000051	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
290512000052	Protein export membrane protein; Region: SecD_SecF; pfam02355
290512000053	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
290512000054	SurA N-terminal domain; Region: SurA_N; pfam09312
290512000055	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
290512000056	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
290512000057	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
290512000058	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290512000059	ATP binding site [chemical binding]; other site
290512000060	Mg2+ binding site [ion binding]; other site
290512000061	G-X-G motif; other site
290512000062	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
290512000063	anchoring element; other site
290512000064	dimer interface [polypeptide binding]; other site
290512000065	ATP binding site [chemical binding]; other site
290512000066	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
290512000067	active site
290512000068	putative metal-binding site [ion binding]; other site
290512000069	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
290512000070	hypothetical protein; Reviewed; Region: PRK12497
290512000071	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
290512000072	RNA/DNA hybrid binding site [nucleotide binding]; other site
290512000073	active site
290512000074	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
290512000075	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
290512000076	homodimer interface [polypeptide binding]; other site
290512000077	oligonucleotide binding site [chemical binding]; other site
290512000078	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
290512000079	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
290512000080	trimer interface [polypeptide binding]; other site
290512000081	active site
290512000082	substrate binding site [chemical binding]; other site
290512000083	CoA binding site [chemical binding]; other site
290512000084	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
290512000085	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
290512000086	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
290512000087	protein binding site [polypeptide binding]; other site
290512000088	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
290512000089	Catalytic dyad [active]
290512000090	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
290512000091	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
290512000092	geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023
290512000093	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
290512000094	glycyl-tRNA synthetase; Provisional; Region: PRK04173
290512000095	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
290512000096	motif 1; other site
290512000097	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
290512000098	active site
290512000099	motif 2; other site
290512000100	motif 3; other site
290512000101	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
290512000102	anticodon binding site; other site
290512000103	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
290512000104	active site residue [active]
290512000105	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
290512000106	CPxP  motif; other site
290512000107	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
290512000108	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
290512000109	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
290512000110	catalytic triad [active]
290512000111	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
290512000112	DsrC like protein; Region: DsrC; pfam04358
290512000113	sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064
290512000114	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
290512000115	sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066
290512000116	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
290512000117	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
290512000118	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290512000119	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
290512000120	DsrE/DsrF-like family; Region: DrsE; cl00672
290512000121	sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010
290512000122	DsrH like protein; Region: DsrH; pfam04077
290512000123	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
290512000124	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
290512000125	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
290512000126	Cysteine-rich domain; Region: CCG; pfam02754
290512000127	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
290512000128	4Fe-4S binding domain; Region: Fer4; cl02805
290512000129	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
290512000130	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
290512000131	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
290512000132	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
290512000133	active site
290512000134	SAM binding site [chemical binding]; other site
290512000135	homodimer interface [polypeptide binding]; other site
290512000136	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
290512000137	active site
290512000138	patatin-related protein; Region: TIGR03607
290512000139	Patatin-like phospholipase; Region: Patatin; pfam01734
290512000140	nucleophile elbow; other site
290512000141	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617
290512000142	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
290512000143	dimer interface [polypeptide binding]; other site
290512000144	catalytic triad [active]
290512000145	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
290512000146	gamma subunit interface [polypeptide binding]; other site
290512000147	epsilon subunit interface [polypeptide binding]; other site
290512000148	LBP interface [polypeptide binding]; other site
290512000149	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
290512000150	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
290512000151	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
290512000152	alpha subunit interaction interface [polypeptide binding]; other site
290512000153	Walker A motif; other site
290512000154	ATP binding site [chemical binding]; other site
290512000155	Walker B motif; other site
290512000156	inhibitor binding site; inhibition site
290512000157	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
290512000158	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
290512000159	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
290512000160	catalytic residues [active]
290512000161	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
290512000162	active site
290512000163	substrate-binding site [chemical binding]; other site
290512000164	metal-binding site [ion binding]
290512000165	GTP binding site [chemical binding]; other site
290512000166	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
290512000167	Dodecin; Region: Dodecin; pfam07311
290512000168	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
290512000169	4Fe-4S binding domain; Region: Fer4; pfam00037
290512000170	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
290512000171	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
290512000172	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
290512000173	molybdopterin cofactor binding site; other site
290512000174	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
290512000175	putative molybdopterin cofactor binding site; other site
290512000176	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
290512000177	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
290512000178	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
290512000179	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290512000180	ATP binding site [chemical binding]; other site
290512000181	putative Mg++ binding site [ion binding]; other site
290512000182	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290512000183	nucleotide binding region [chemical binding]; other site
290512000184	ATP-binding site [chemical binding]; other site
290512000185	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
290512000186	HRDC domain; Region: HRDC; pfam00570
290512000187	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440
290512000188	HNH endonuclease; Region: HNH_2; pfam13391
290512000189	Winged helix-turn helix; Region: HTH_29; pfam13551
290512000190	Homeodomain-like domain; Region: HTH_32; pfam13565
290512000191	DDE superfamily endonuclease; Region: DDE_3; pfam13358
290512000192	DDE superfamily endonuclease; Region: DDE_3; pfam13358
290512000193	FRG domain; Region: FRG; pfam08867
290512000194	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
290512000195	synthetase active site [active]
290512000196	NTP binding site [chemical binding]; other site
290512000197	metal binding site [ion binding]; metal-binding site
290512000198	DDE superfamily endonuclease; Region: DDE_3; pfam13358
290512000199	Winged helix-turn helix; Region: HTH_29; pfam13551
290512000200	Homeodomain-like domain; Region: HTH_23; pfam13384
290512000201	Homeodomain-like domain; Region: HTH_32; pfam13565
290512000202	HTH-like domain; Region: HTH_21; pfam13276
290512000203	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
290512000204	DNA-binding interface [nucleotide binding]; DNA binding site
290512000205	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
290512000206	Transposase; Region: DEDD_Tnp_IS110; pfam01548
290512000207	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
290512000208	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
290512000209	Methyltransferase domain; Region: Methyltransf_23; pfam13489
290512000210	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290512000211	S-adenosylmethionine binding site [chemical binding]; other site
290512000212	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
290512000213	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
290512000214	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
290512000215	putative active site [active]
290512000216	putative NTP binding site [chemical binding]; other site
290512000217	putative nucleic acid binding site [nucleotide binding]; other site
290512000218	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
290512000219	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
290512000220	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
290512000221	PhnA protein; Region: PhnA; pfam03831
290512000222	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
290512000223	A new structural DNA glycosylase; Region: AlkD_like; cd06561
290512000224	active site
290512000225	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290512000226	H+ Antiporter protein; Region: 2A0121; TIGR00900
290512000227	putative substrate translocation pore; other site
290512000228	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
290512000229	SelR domain; Region: SelR; pfam01641
290512000230	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647
290512000231	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
290512000232	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
290512000233	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
290512000234	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509
290512000235	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12659
290512000236	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
290512000237	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
290512000238	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
290512000239	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
290512000240	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
290512000241	Phytase; Region: Phytase; cl17685
290512000242	Cna protein B-type domain; Region: Cna_B_2; pfam13715
290512000243	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
290512000244	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
290512000245	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
290512000246	ligand-binding site [chemical binding]; other site
290512000247	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352
290512000248	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
290512000249	active site
290512000250	catalytic site [active]
290512000251	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
290512000252	xanthine permease; Region: pbuX; TIGR03173
290512000253	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
290512000254	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
290512000255	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
290512000256	TrkA-N domain; Region: TrkA_N; pfam02254
290512000257	TrkA-C domain; Region: TrkA_C; pfam02080
290512000258	TrkA-N domain; Region: TrkA_N; pfam02254
290512000259	TrkA-C domain; Region: TrkA_C; pfam02080
290512000260	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
290512000261	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
290512000262	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
290512000263	TrkA-N domain; Region: TrkA_N; pfam02254
290512000264	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
290512000265	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
290512000266	putative oligomer interface [polypeptide binding]; other site
290512000267	putative active site [active]
290512000268	metal binding site [ion binding]; metal-binding site
290512000269	GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT
290512000270	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
290512000271	Coenzyme A binding pocket [chemical binding]; other site
290512000272	ATP-grasp domain; Region: ATP-grasp_4; cl17255
290512000273	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
290512000274	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
290512000275	active site
290512000276	dimer interface [polypeptide binding]; other site
290512000277	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
290512000278	Ligand Binding Site [chemical binding]; other site
290512000279	Molecular Tunnel; other site
290512000280	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
290512000281	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
290512000282	DTAP/Switch II; other site
290512000283	Switch I; other site
290512000284	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
290512000285	putative FMN binding site [chemical binding]; other site
290512000286	Ion channel; Region: Ion_trans_2; pfam07885
290512000287	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
290512000288	TrkA-N domain; Region: TrkA_N; pfam02254
290512000289	TrkA-C domain; Region: TrkA_C; pfam02080
290512000290	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
290512000291	peptide chain release factor 1; Validated; Region: prfA; PRK00591
290512000292	This domain is found in peptide chain release factors; Region: PCRF; smart00937
290512000293	RF-1 domain; Region: RF-1; pfam00472
290512000294	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
290512000295	RIP metalloprotease RseP; Region: TIGR00054
290512000296	active site
290512000297	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
290512000298	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
290512000299	protein binding site [polypeptide binding]; other site
290512000300	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
290512000301	putative substrate binding region [chemical binding]; other site
290512000302	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
290512000303	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
290512000304	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
290512000305	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
290512000306	Acylphosphatase; Region: Acylphosphatase; pfam00708
290512000307	FtsH Extracellular; Region: FtsH_ext; pfam06480
290512000308	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
290512000309	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290512000310	Walker B motif; other site
290512000311	arginine finger; other site
290512000312	Peptidase family M41; Region: Peptidase_M41; pfam01434
290512000313	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
290512000314	active site
290512000315	dimer interface [polypeptide binding]; other site
290512000316	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
290512000317	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
290512000318	glutaminase active site [active]
290512000319	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
290512000320	dimer interface [polypeptide binding]; other site
290512000321	active site
290512000322	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
290512000323	dimer interface [polypeptide binding]; other site
290512000324	active site
290512000325	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
290512000326	TIGR01777 family protein; Region: yfcH
290512000327	putative NAD(P) binding site [chemical binding]; other site
290512000328	putative active site [active]
290512000329	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
290512000330	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
290512000331	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
290512000332	Nitrogen regulatory protein P-II; Region: P-II; smart00938
290512000333	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
290512000334	active site
290512000335	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512000336	TPR motif; other site
290512000337	binding surface
290512000338	TPR repeat; Region: TPR_11; pfam13414
290512000339	TPR repeat; Region: TPR_11; pfam13414
290512000340	ScpA/B protein; Region: ScpA_ScpB; cl00598
290512000341	Uncharacterized conserved protein [Function unknown]; Region: COG4198
290512000342	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
290512000343	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
290512000344	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
290512000345	Glycoprotease family; Region: Peptidase_M22; pfam00814
290512000346	Oligomerisation domain; Region: Oligomerisation; pfam02410
290512000347	DNA gyrase subunit A; Validated; Region: PRK05560
290512000348	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
290512000349	CAP-like domain; other site
290512000350	active site
290512000351	primary dimer interface [polypeptide binding]; other site
290512000352	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
290512000353	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
290512000354	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
290512000355	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
290512000356	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
290512000357	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
290512000358	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
290512000359	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
290512000360	CTP synthetase; Validated; Region: pyrG; PRK05380
290512000361	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
290512000362	Catalytic site [active]
290512000363	active site
290512000364	UTP binding site [chemical binding]; other site
290512000365	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
290512000366	active site
290512000367	putative oxyanion hole; other site
290512000368	catalytic triad [active]
290512000369	nif11-like leader peptide domain; Region: ocin_TIGR03798
290512000370	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
290512000371	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512000372	FeS/SAM binding site; other site
290512000373	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
290512000374	Na+/H+ antiporter 1; Region: Na_H_antiport_1; pfam06965
290512000375	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
290512000376	PHP domain; Region: PHP; pfam02811
290512000377	active site
290512000378	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
290512000379	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
290512000380	dimer interface [polypeptide binding]; other site
290512000381	active site
290512000382	heme binding site [chemical binding]; other site
290512000383	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
290512000384	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
290512000385	metal binding site 2 [ion binding]; metal-binding site
290512000386	putative DNA binding helix; other site
290512000387	metal binding site 1 [ion binding]; metal-binding site
290512000388	dimer interface [polypeptide binding]; other site
290512000389	structural Zn2+ binding site [ion binding]; other site
290512000390	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
290512000391	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
290512000392	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
290512000393	active site
290512000394	Domain of Unknown Function (DUF3856); Region: DUF3856; pfam12968
290512000395	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
290512000396	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
290512000397	putative active site [active]
290512000398	Exonuclease III [DNA replication, recombination, and repair]; Region: XthA; COG0708
290512000399	putative catalytic site [active]
290512000400	putative metal binding site [ion binding]; other site
290512000401	putative phosphate binding site [ion binding]; other site
290512000402	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
290512000403	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
290512000404	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
290512000405	dimer interface [polypeptide binding]; other site
290512000406	ssDNA binding site [nucleotide binding]; other site
290512000407	tetramer (dimer of dimers) interface [polypeptide binding]; other site
290512000408	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
290512000409	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
290512000410	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
290512000411	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
290512000412	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
290512000413	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
290512000414	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
290512000415	dimer interface [polypeptide binding]; other site
290512000416	motif 1; other site
290512000417	active site
290512000418	motif 2; other site
290512000419	motif 3; other site
290512000420	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
290512000421	23S rRNA binding site [nucleotide binding]; other site
290512000422	L21 binding site [polypeptide binding]; other site
290512000423	L13 binding site [polypeptide binding]; other site
290512000424	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
290512000425	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
290512000426	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
290512000427	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
290512000428	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
290512000429	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
290512000430	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
290512000431	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
290512000432	active site
290512000433	dimer interface [polypeptide binding]; other site
290512000434	motif 1; other site
290512000435	motif 2; other site
290512000436	motif 3; other site
290512000437	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
290512000438	anticodon binding site; other site
290512000439	chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014
290512000440	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
290512000441	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
290512000442	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
290512000443	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
290512000444	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
290512000445	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
290512000446	active site
290512000447	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
290512000448	tetramer interface [polypeptide binding]; other site
290512000449	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290512000450	catalytic residue [active]
290512000451	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
290512000452	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
290512000453	dimerization interface [polypeptide binding]; other site
290512000454	active site
290512000455	metal binding site [ion binding]; metal-binding site
290512000456	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
290512000457	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
290512000458	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
290512000459	dimer interface [polypeptide binding]; other site
290512000460	active site
290512000461	acyl carrier protein; Provisional; Region: acpP; PRK00982
290512000462	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
290512000463	NAD(P) binding site [chemical binding]; other site
290512000464	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
290512000465	homotetramer interface [polypeptide binding]; other site
290512000466	homodimer interface [polypeptide binding]; other site
290512000467	active site
290512000468	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
290512000469	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
290512000470	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
290512000471	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
290512000472	dimer interface [polypeptide binding]; other site
290512000473	active site
290512000474	CoA binding pocket [chemical binding]; other site
290512000475	putative phosphate acyltransferase; Provisional; Region: PRK05331
290512000476	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
290512000477	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
290512000478	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
290512000479	putative active site [active]
290512000480	GIY-YIG motif/motif A; other site
290512000481	putative metal binding site [ion binding]; other site
290512000482	lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523
290512000483	NlpE N-terminal domain; Region: NlpE; pfam04170
290512000484	META domain; Region: META; pfam03724
290512000485	2-isopropylmalate synthase; Validated; Region: PRK03739
290512000486	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
290512000487	active site
290512000488	catalytic residues [active]
290512000489	metal binding site [ion binding]; metal-binding site
290512000490	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
290512000491	ferric uptake regulator; Provisional; Region: fur; PRK09462
290512000492	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
290512000493	metal binding site 2 [ion binding]; metal-binding site
290512000494	putative DNA binding helix; other site
290512000495	metal binding site 1 [ion binding]; metal-binding site
290512000496	dimer interface [polypeptide binding]; other site
290512000497	structural Zn2+ binding site [ion binding]; other site
290512000498	Metal binding protein ZntC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018
290512000499	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
290512000500	putative metal binding residues [ion binding]; other site
290512000501	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
290512000502	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
290512000503	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
290512000504	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
290512000505	ABC-ATPase subunit  interface; other site
290512000506	dimer interface [polypeptide binding]; other site
290512000507	putative PBP binding regions; other site
290512000508	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
290512000509	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
290512000510	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
290512000511	camphor resistance protein CrcB; Provisional; Region: PRK14202
290512000512	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
290512000513	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
290512000514	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
290512000515	inhibitor-cofactor binding pocket; inhibition site
290512000516	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290512000517	catalytic residue [active]
290512000518	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
290512000519	Recombination protein O N terminal; Region: RecO_N; pfam11967
290512000520	Recombination protein O C terminal; Region: RecO_C; pfam02565
290512000521	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
290512000522	OstA-like protein; Region: OstA_2; pfam13100
290512000523	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
290512000524	active site
290512000525	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
290512000526	homodimer interface [polypeptide binding]; other site
290512000527	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
290512000528	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512000529	FeS/SAM binding site; other site
290512000530	Radical SAM superfamily; Region: Radical_SAM; pfam04055
290512000531	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
290512000532	CHAT domain; Region: CHAT; pfam12770
290512000533	Caspase domain; Region: Peptidase_C14; pfam00656
290512000534	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
290512000535	TIR domain; Region: TIR_2; pfam13676
290512000536	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603
290512000537	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
290512000538	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
290512000539	Peptidase family M23; Region: Peptidase_M23; pfam01551
290512000540	Homo sapiens Nbla03831 and related proteins, metallophosphatase domain; Region: MPP_Nbla03831; cd07396
290512000541	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
290512000542	active site
290512000543	metal binding site [ion binding]; metal-binding site
290512000544	peptide chain release factor 2; Validated; Region: prfB; PRK00578
290512000545	PCRF domain; Region: PCRF; pfam03462
290512000546	RF-1 domain; Region: RF-1; pfam00472
290512000547	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
290512000548	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
290512000549	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
290512000550	active site
290512000551	homodimer interface [polypeptide binding]; other site
290512000552	catalytic site [active]
290512000553	acceptor binding site [chemical binding]; other site
290512000554	trehalose synthase; Region: treS_nterm; TIGR02456
290512000555	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
290512000556	active site
290512000557	catalytic site [active]
290512000558	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
290512000559	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
290512000560	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
290512000561	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
290512000562	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
290512000563	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
290512000564	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290512000565	motif II; other site
290512000566	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
290512000567	Predicted esterase [General function prediction only]; Region: COG0400
290512000568	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
290512000569	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
290512000570	homodimer interface [polypeptide binding]; other site
290512000571	metal binding site [ion binding]; metal-binding site
290512000572	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
290512000573	homodimer interface [polypeptide binding]; other site
290512000574	active site
290512000575	putative chemical substrate binding site [chemical binding]; other site
290512000576	metal binding site [ion binding]; metal-binding site
290512000577	short chain dehydrogenase; Provisional; Region: PRK07326
290512000578	classical (c) SDRs; Region: SDR_c; cd05233
290512000579	NAD(P) binding site [chemical binding]; other site
290512000580	active site
290512000581	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
290512000582	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
290512000583	trmE is a tRNA modification GTPase; Region: trmE; cd04164
290512000584	G1 box; other site
290512000585	GTP/Mg2+ binding site [chemical binding]; other site
290512000586	Switch I region; other site
290512000587	G2 box; other site
290512000588	Switch II region; other site
290512000589	G3 box; other site
290512000590	G4 box; other site
290512000591	G5 box; other site
290512000592	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
290512000593	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
290512000594	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
290512000595	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
290512000596	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
290512000597	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
290512000598	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
290512000599	P loop; other site
290512000600	Nucleotide binding site [chemical binding]; other site
290512000601	DTAP/Switch II; other site
290512000602	Switch I; other site
290512000603	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
290512000604	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290512000605	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290512000606	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
290512000607	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290512000608	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290512000609	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290512000610	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
290512000611	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
290512000612	NADH(P)-binding; Region: NAD_binding_10; pfam13460
290512000613	NAD(P) binding site [chemical binding]; other site
290512000614	putative active site [active]
290512000615	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512000616	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
290512000617	FeS/SAM binding site; other site
290512000618	Methyltransferase domain; Region: Methyltransf_31; pfam13847
290512000619	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290512000620	S-adenosylmethionine binding site [chemical binding]; other site
290512000621	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
290512000622	Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043
290512000623	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493
290512000624	Na binding site [ion binding]; other site
290512000625	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
290512000626	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
290512000627	glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091
290512000628	Substrate binding site; other site
290512000629	metal-binding site
290512000630	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
290512000631	putative trimer interface [polypeptide binding]; other site
290512000632	putative CoA binding site [chemical binding]; other site
290512000633	Phosphotransferase enzyme family; Region: APH; pfam01636
290512000634	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
290512000635	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
290512000636	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
290512000637	putative homodimer interface [polypeptide binding]; other site
290512000638	putative homotetramer interface [polypeptide binding]; other site
290512000639	putative allosteric switch controlling residues; other site
290512000640	putative metal binding site [ion binding]; other site
290512000641	putative homodimer-homodimer interface [polypeptide binding]; other site
290512000642	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
290512000643	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290512000644	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
290512000645	Protein export membrane protein; Region: SecD_SecF; cl14618
290512000646	Protein export membrane protein; Region: SecD_SecF; cl14618
290512000647	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
290512000648	FOG: CBS domain [General function prediction only]; Region: COG0517
290512000649	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
290512000650	L-aspartate oxidase; Provisional; Region: PRK06175
290512000651	succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812
290512000652	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
290512000653	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
290512000654	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
290512000655	catalytic loop [active]
290512000656	iron binding site [ion binding]; other site
290512000657	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
290512000658	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
290512000659	Cysteine-rich domain; Region: CCG; pfam02754
290512000660	Cysteine-rich domain; Region: CCG; pfam02754
290512000661	Class I aldolases; Region: Aldolase_Class_I; cl17187
290512000662	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
290512000663	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
290512000664	substrate binding site [chemical binding]; other site
290512000665	active site
290512000666	Ion transport protein; Region: Ion_trans; pfam00520
290512000667	Ion channel; Region: Ion_trans_2; pfam07885
290512000668	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290512000669	Ligand Binding Site [chemical binding]; other site
290512000670	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290512000671	Ligand Binding Site [chemical binding]; other site
290512000672	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
290512000673	dimer interface [polypeptide binding]; other site
290512000674	active site
290512000675	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
290512000676	homopentamer interface [polypeptide binding]; other site
290512000677	active site
290512000678	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290512000679	PAS domain; Region: PAS_9; pfam13426
290512000680	putative active site [active]
290512000681	heme pocket [chemical binding]; other site
290512000682	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
290512000683	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
290512000684	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
290512000685	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290512000686	dimer interface [polypeptide binding]; other site
290512000687	phosphorylation site [posttranslational modification]
290512000688	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290512000689	ATP binding site [chemical binding]; other site
290512000690	Mg2+ binding site [ion binding]; other site
290512000691	G-X-G motif; other site
290512000692	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290512000693	Response regulator receiver domain; Region: Response_reg; pfam00072
290512000694	active site
290512000695	phosphorylation site [posttranslational modification]
290512000696	intermolecular recognition site; other site
290512000697	dimerization interface [polypeptide binding]; other site
290512000698	Response regulator receiver domain; Region: Response_reg; pfam00072
290512000699	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290512000700	active site
290512000701	phosphorylation site [posttranslational modification]
290512000702	intermolecular recognition site; other site
290512000703	dimerization interface [polypeptide binding]; other site
290512000704	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
290512000705	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
290512000706	putative acyl-acceptor binding pocket; other site
290512000707	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
290512000708	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
290512000709	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290512000710	catalytic residue [active]
290512000711	homoserine kinase; Provisional; Region: PRK01212
290512000712	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
290512000713	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
290512000714	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
290512000715	beta subunit interaction interface [polypeptide binding]; other site
290512000716	Walker A motif; other site
290512000717	ATP binding site [chemical binding]; other site
290512000718	Walker B motif; other site
290512000719	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
290512000720	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
290512000721	core domain interface [polypeptide binding]; other site
290512000722	delta subunit interface [polypeptide binding]; other site
290512000723	epsilon subunit interface [polypeptide binding]; other site
290512000724	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
290512000725	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
290512000726	putative catalytic residues [active]
290512000727	putative nucleotide binding site [chemical binding]; other site
290512000728	putative aspartate binding site [chemical binding]; other site
290512000729	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
290512000730	dimer interface [polypeptide binding]; other site
290512000731	putative threonine allosteric regulatory site; other site
290512000732	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
290512000733	putative threonine allosteric regulatory site; other site
290512000734	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
290512000735	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
290512000736	competence damage-inducible protein A; Provisional; Region: PRK00549
290512000737	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
290512000738	putative MPT binding site; other site
290512000739	Competence-damaged protein; Region: CinA; pfam02464
290512000740	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
290512000741	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290512000742	ATP binding site [chemical binding]; other site
290512000743	Mg2+ binding site [ion binding]; other site
290512000744	G-X-G motif; other site
290512000745	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
290512000746	ATP binding site [chemical binding]; other site
290512000747	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
290512000748	Cytochrome c; Region: Cytochrom_C; pfam00034
290512000749	Transglycosylase; Region: Transgly; cl17702
290512000750	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
290512000751	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290512000752	Walker A/P-loop; other site
290512000753	ATP binding site [chemical binding]; other site
290512000754	Q-loop/lid; other site
290512000755	ABC transporter signature motif; other site
290512000756	Walker B; other site
290512000757	D-loop; other site
290512000758	H-loop/switch region; other site
290512000759	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
290512000760	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
290512000761	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
290512000762	putative ligand binding pocket/active site [active]
290512000763	putative metal binding site [ion binding]; other site
290512000764	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
290512000765	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
290512000766	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
290512000767	Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224
290512000768	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
290512000769	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
290512000770	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
290512000771	Ligand binding site; other site
290512000772	Putative Catalytic site; other site
290512000773	DXD motif; other site
290512000774	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
290512000775	elongation factor G; Reviewed; Region: PRK12740
290512000776	G1 box; other site
290512000777	putative GEF interaction site [polypeptide binding]; other site
290512000778	GTP/Mg2+ binding site [chemical binding]; other site
290512000779	Switch I region; other site
290512000780	G2 box; other site
290512000781	G3 box; other site
290512000782	Switch II region; other site
290512000783	G4 box; other site
290512000784	G5 box; other site
290512000785	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
290512000786	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
290512000787	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
290512000788	enolase; Provisional; Region: eno; PRK00077
290512000789	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
290512000790	dimer interface [polypeptide binding]; other site
290512000791	metal binding site [ion binding]; metal-binding site
290512000792	substrate binding pocket [chemical binding]; other site
290512000793	Septum formation initiator; Region: DivIC; cl17659
290512000794	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
290512000795	GcpE protein; Region: GcpE; pfam04551
290512000796	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
290512000797	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
290512000798	classical (c) SDRs; Region: SDR_c; cd05233
290512000799	NAD(P) binding site [chemical binding]; other site
290512000800	active site
290512000801	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
290512000802	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
290512000803	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
290512000804	putative homodimer interface [polypeptide binding]; other site
290512000805	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
290512000806	heterodimer interface [polypeptide binding]; other site
290512000807	homodimer interface [polypeptide binding]; other site
290512000808	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
290512000809	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
290512000810	23S rRNA interface [nucleotide binding]; other site
290512000811	L7/L12 interface [polypeptide binding]; other site
290512000812	putative thiostrepton binding site; other site
290512000813	L25 interface [polypeptide binding]; other site
290512000814	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
290512000815	mRNA/rRNA interface [nucleotide binding]; other site
290512000816	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
290512000817	23S rRNA interface [nucleotide binding]; other site
290512000818	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
290512000819	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
290512000820	core dimer interface [polypeptide binding]; other site
290512000821	peripheral dimer interface [polypeptide binding]; other site
290512000822	L10 interface [polypeptide binding]; other site
290512000823	L11 interface [polypeptide binding]; other site
290512000824	putative EF-Tu interaction site [polypeptide binding]; other site
290512000825	putative EF-G interaction site [polypeptide binding]; other site
290512000826	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
290512000827	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
290512000828	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
290512000829	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
290512000830	RPB11 interaction site [polypeptide binding]; other site
290512000831	RPB12 interaction site [polypeptide binding]; other site
290512000832	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
290512000833	RPB3 interaction site [polypeptide binding]; other site
290512000834	RPB1 interaction site [polypeptide binding]; other site
290512000835	RPB11 interaction site [polypeptide binding]; other site
290512000836	RPB10 interaction site [polypeptide binding]; other site
290512000837	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
290512000838	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
290512000839	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
290512000840	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
290512000841	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
290512000842	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
290512000843	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
290512000844	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
290512000845	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
290512000846	DNA binding site [nucleotide binding]
290512000847	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
290512000848	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
290512000849	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
290512000850	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
290512000851	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
290512000852	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
290512000853	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
290512000854	carboxyltransferase (CT) interaction site; other site
290512000855	biotinylation site [posttranslational modification]; other site
290512000856	elongation factor P; Validated; Region: PRK00529
290512000857	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
290512000858	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
290512000859	RNA binding site [nucleotide binding]; other site
290512000860	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
290512000861	RNA binding site [nucleotide binding]; other site
290512000862	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
290512000863	IHF - DNA interface [nucleotide binding]; other site
290512000864	IHF dimer interface [polypeptide binding]; other site
290512000865	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
290512000866	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
290512000867	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
290512000868	TPP-binding site [chemical binding]; other site
290512000869	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
290512000870	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
290512000871	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
290512000872	dimer interface [polypeptide binding]; other site
290512000873	PYR/PP interface [polypeptide binding]; other site
290512000874	TPP binding site [chemical binding]; other site
290512000875	substrate binding site [chemical binding]; other site
290512000876	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
290512000877	PAS fold; Region: PAS_4; pfam08448
290512000878	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290512000879	putative active site [active]
290512000880	heme pocket [chemical binding]; other site
290512000881	Cupin domain; Region: Cupin_2; pfam07883
290512000882	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
290512000883	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
290512000884	motif 1; other site
290512000885	active site
290512000886	motif 2; other site
290512000887	motif 3; other site
290512000888	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
290512000889	Ferredoxin [Energy production and conversion]; Region: COG1146
290512000890	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
290512000891	HsdM N-terminal domain; Region: HsdM_N; pfam12161
290512000892	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
290512000893	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
290512000894	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
290512000895	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
290512000896	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
290512000897	SIR2-like domain; Region: SIR2_2; pfam13289
290512000898	Domain of unknown function DUF87; Region: DUF87; pfam01935
290512000899	HerA helicase [Replication, recombination, and repair]; Region: COG0433
290512000900	KTSC domain; Region: KTSC; pfam13619
290512000901	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
290512000902	Transposase IS200 like; Region: Y1_Tnp; cl00848
290512000903	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
290512000904	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290512000905	ATP binding site [chemical binding]; other site
290512000906	putative Mg++ binding site [ion binding]; other site
290512000907	Protein of unknown function DUF45; Region: DUF45; cl00636
290512000908	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
290512000909	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
290512000910	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
290512000911	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
290512000912	phosphoserine phosphatase SerB; Region: serB; TIGR00338
290512000913	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290512000914	motif II; other site
290512000915	GMP synthase; Reviewed; Region: guaA; PRK00074
290512000916	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
290512000917	AMP/PPi binding site [chemical binding]; other site
290512000918	candidate oxyanion hole; other site
290512000919	catalytic triad [active]
290512000920	potential glutamine specificity residues [chemical binding]; other site
290512000921	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
290512000922	ATP Binding subdomain [chemical binding]; other site
290512000923	Ligand Binding sites [chemical binding]; other site
290512000924	Dimerization subdomain; other site
290512000925	Transglycosylase; Region: Transgly; pfam00912
290512000926	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
290512000927	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
290512000928	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
290512000929	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
290512000930	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
290512000931	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
290512000932	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290512000933	hydroxyglutarate oxidase; Provisional; Region: PRK11728
290512000934	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
290512000935	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
290512000936	Domain of unknown function (DUF1924); Region: DUF1924; pfam09086
290512000937	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
290512000938	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
290512000939	putative NAD(P) binding site [chemical binding]; other site
290512000940	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
290512000941	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
290512000942	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
290512000943	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
290512000944	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
290512000945	catalytic triad [active]
290512000946	AAA domain; Region: AAA_28; pfam13521
290512000947	Predicted ATPase [General function prediction only]; Region: COG3911
290512000948	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
290512000949	Clp amino terminal domain; Region: Clp_N; pfam02861
290512000950	Clp amino terminal domain; Region: Clp_N; pfam02861
290512000951	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290512000952	Walker A motif; other site
290512000953	ATP binding site [chemical binding]; other site
290512000954	Walker B motif; other site
290512000955	arginine finger; other site
290512000956	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290512000957	Walker A motif; other site
290512000958	ATP binding site [chemical binding]; other site
290512000959	Walker B motif; other site
290512000960	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
290512000961	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
290512000962	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
290512000963	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290512000964	catalytic residue [active]
290512000965	thiamine monophosphate kinase; Provisional; Region: PRK05731
290512000966	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
290512000967	ATP binding site [chemical binding]; other site
290512000968	dimerization interface [polypeptide binding]; other site
290512000969	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
290512000970	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
290512000971	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
290512000972	P loop; other site
290512000973	GTP binding site [chemical binding]; other site
290512000974	GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441
290512000975	GIY-YIG motif/motif A; other site
290512000976	putative active site [active]
290512000977	putative metal binding site [ion binding]; other site
290512000978	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
290512000979	Methyltransferase domain; Region: Methyltransf_18; pfam12847
290512000980	SurA N-terminal domain; Region: SurA_N_3; cl07813
290512000981	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
290512000982	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
290512000983	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
290512000984	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
290512000985	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
290512000986	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
290512000987	replicative DNA helicase; Region: DnaB; TIGR00665
290512000988	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
290512000989	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
290512000990	Walker A motif; other site
290512000991	ATP binding site [chemical binding]; other site
290512000992	Walker B motif; other site
290512000993	DNA binding loops [nucleotide binding]
290512000994	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
290512000995	Fe-S cluster binding site [ion binding]; other site
290512000996	active site
290512000997	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
290512000998	Flavoprotein; Region: Flavoprotein; pfam02441
290512000999	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
290512001000	Family of unknown function (DUF490); Region: DUF490; pfam04357
290512001001	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
290512001002	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
290512001003	active site
290512001004	nucleotide binding site [chemical binding]; other site
290512001005	HIGH motif; other site
290512001006	KMSKS motif; other site
290512001007	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
290512001008	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
290512001009	putative acyl-acceptor binding pocket; other site
290512001010	DNA polymerase III subunit delta'; Validated; Region: PRK06871
290512001011	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
290512001012	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
290512001013	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
290512001014	Walker A/P-loop; other site
290512001015	ATP binding site [chemical binding]; other site
290512001016	Q-loop/lid; other site
290512001017	ABC transporter signature motif; other site
290512001018	Walker B; other site
290512001019	D-loop; other site
290512001020	H-loop/switch region; other site
290512001021	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
290512001022	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
290512001023	active site
290512001024	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
290512001025	active site
290512001026	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290512001027	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
290512001028	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290512001029	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
290512001030	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
290512001031	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
290512001032	active site
290512001033	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
290512001034	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290512001035	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290512001036	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
290512001037	putative ADP-binding pocket [chemical binding]; other site
290512001038	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290512001039	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
290512001040	putative ADP-binding pocket [chemical binding]; other site
290512001041	hypothetical protein; Provisional; Region: PRK10345
290512001042	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
290512001043	putative ADP-binding pocket [chemical binding]; other site
290512001044	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290512001045	CAAX protease self-immunity; Region: Abi; pfam02517
290512001046	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
290512001047	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
290512001048	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
290512001049	active site
290512001050	phosphorylation site [posttranslational modification]
290512001051	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
290512001052	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
290512001053	dimer interface [polypeptide binding]; other site
290512001054	motif 1; other site
290512001055	active site
290512001056	motif 2; other site
290512001057	motif 3; other site
290512001058	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
290512001059	anticodon binding site; other site
290512001060	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
290512001061	hypothetical protein; Provisional; Region: PRK14641
290512001062	Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576
290512001063	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
290512001064	NusA N-terminal domain; Region: NusA_N; pfam08529
290512001065	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
290512001066	RNA binding site [nucleotide binding]; other site
290512001067	homodimer interface [polypeptide binding]; other site
290512001068	NusA-like KH domain; Region: KH_5; pfam13184
290512001069	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
290512001070	G-X-X-G motif; other site
290512001071	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
290512001072	translation initiation factor IF-2; Region: IF-2; TIGR00487
290512001073	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
290512001074	G1 box; other site
290512001075	putative GEF interaction site [polypeptide binding]; other site
290512001076	GTP/Mg2+ binding site [chemical binding]; other site
290512001077	Switch I region; other site
290512001078	G2 box; other site
290512001079	G3 box; other site
290512001080	Switch II region; other site
290512001081	G4 box; other site
290512001082	G5 box; other site
290512001083	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
290512001084	Translation-initiation factor 2; Region: IF-2; pfam11987
290512001085	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
290512001086	Ribosome-binding factor A; Region: RBFA; pfam02033
290512001087	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
290512001088	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
290512001089	RNA binding site [nucleotide binding]; other site
290512001090	active site
290512001091	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
290512001092	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
290512001093	active site
290512001094	Riboflavin kinase; Region: Flavokinase; pfam01687
290512001095	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
290512001096	16S/18S rRNA binding site [nucleotide binding]; other site
290512001097	S13e-L30e interaction site [polypeptide binding]; other site
290512001098	25S rRNA binding site [nucleotide binding]; other site
290512001099	hypothetical protein; Provisional; Region: PRK11820
290512001100	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
290512001101	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
290512001102	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
290512001103	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
290512001104	catalytic site [active]
290512001105	G-X2-G-X-G-K; other site
290512001106	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
290512001107	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
290512001108	active site
290512001109	metal binding site [ion binding]; metal-binding site
290512001110	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
290512001111	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
290512001112	active site
290512001113	ADP/pyrophosphate binding site [chemical binding]; other site
290512001114	dimerization interface [polypeptide binding]; other site
290512001115	allosteric effector site; other site
290512001116	fructose-1,6-bisphosphate binding site; other site
290512001117	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
290512001118	Substrate binding site; other site
290512001119	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
290512001120	Mg++ binding site; other site
290512001121	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
290512001122	tetramerization interface [polypeptide binding]; other site
290512001123	active site
290512001124	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
290512001125	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
290512001126	periplasmic chaperone; Provisional; Region: PRK10780
290512001127	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
290512001128	DNA protecting protein DprA; Region: dprA; TIGR00732
290512001129	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
290512001130	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
290512001131	substrate binding pocket [chemical binding]; other site
290512001132	chain length determination region; other site
290512001133	substrate-Mg2+ binding site; other site
290512001134	catalytic residues [active]
290512001135	aspartate-rich region 1; other site
290512001136	active site lid residues [active]
290512001137	aspartate-rich region 2; other site
290512001138	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
290512001139	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
290512001140	homotetramer interface [polypeptide binding]; other site
290512001141	FMN binding site [chemical binding]; other site
290512001142	homodimer contacts [polypeptide binding]; other site
290512001143	putative active site [active]
290512001144	putative substrate binding site [chemical binding]; other site
290512001145	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
290512001146	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290512001147	FtsX-like permease family; Region: FtsX; pfam02687
290512001148	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
290512001149	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
290512001150	active site
290512001151	substrate binding site [chemical binding]; other site
290512001152	metal binding site [ion binding]; metal-binding site
290512001153	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
290512001154	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
290512001155	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
290512001156	Walker A/P-loop; other site
290512001157	ATP binding site [chemical binding]; other site
290512001158	Q-loop/lid; other site
290512001159	ABC transporter signature motif; other site
290512001160	Walker B; other site
290512001161	D-loop; other site
290512001162	H-loop/switch region; other site
290512001163	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
290512001164	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
290512001165	RuvA N terminal domain; Region: RuvA_N; pfam01330
290512001166	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
290512001167	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
290512001168	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
290512001169	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
290512001170	transcription termination factor Rho; Provisional; Region: rho; PRK09376
290512001171	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
290512001172	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
290512001173	RNA binding site [nucleotide binding]; other site
290512001174	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
290512001175	multimer interface [polypeptide binding]; other site
290512001176	Walker A motif; other site
290512001177	ATP binding site [chemical binding]; other site
290512001178	Walker B motif; other site
290512001179	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
290512001180	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
290512001181	DctM-like transporters; Region: DctM; pfam06808
290512001182	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
290512001183	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
290512001184	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
290512001185	Ligand binding site [chemical binding]; other site
290512001186	Electron transfer flavoprotein domain; Region: ETF; pfam01012
290512001187	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
290512001188	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
290512001189	Ligand Binding Site [chemical binding]; other site
290512001190	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
290512001191	Bifunctional nuclease; Region: DNase-RNase; pfam02577
290512001192	UvrB/uvrC motif; Region: UVR; pfam02151
290512001193	Surface antigen; Region: Surface_Ag_2; pfam01617
290512001194	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
290512001195	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
290512001196	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
290512001197	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
290512001198	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
290512001199	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
290512001200	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
290512001201	Surface antigen; Region: Bac_surface_Ag; pfam01103
290512001202	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
290512001203	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
290512001204	catalytic residue [active]
290512001205	putative FPP diphosphate  binding site; other site
290512001206	putative FPP binding hydrophobic cleft; other site
290512001207	dimer interface [polypeptide binding]; other site
290512001208	putative IPP diphosphate binding site; other site
290512001209	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
290512001210	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
290512001211	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
290512001212	CoA binding domain; Region: CoA_binding; smart00881
290512001213	CoA-ligase; Region: Ligase_CoA; pfam00549
290512001214	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
290512001215	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
290512001216	putative active site [active]
290512001217	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
290512001218	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
290512001219	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
290512001220	Heavy-metal resistance; Region: Metal_resist; pfam13801
290512001221	dimer interface [polypeptide binding]; other site
290512001222	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
290512001223	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290512001224	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290512001225	DNA binding residues [nucleotide binding]
290512001226	Methyltransferase domain; Region: Methyltransf_31; pfam13847
290512001227	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290512001228	S-adenosylmethionine binding site [chemical binding]; other site
290512001229	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
290512001230	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
290512001231	active site
290512001232	substrate binding site [chemical binding]; other site
290512001233	metal binding site [ion binding]; metal-binding site
290512001234	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
290512001235	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
290512001236	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
290512001237	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
290512001238	TOBE domain; Region: TOBE; cl01440
290512001239	TOBE domain; Region: TOBE; cl01440
290512001240	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
290512001241	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290512001242	dimer interface [polypeptide binding]; other site
290512001243	conserved gate region; other site
290512001244	putative PBP binding loops; other site
290512001245	ABC-ATPase subunit interface; other site
290512001246	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290512001247	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
290512001248	Walker A/P-loop; other site
290512001249	ATP binding site [chemical binding]; other site
290512001250	Q-loop/lid; other site
290512001251	ABC transporter signature motif; other site
290512001252	Walker B; other site
290512001253	D-loop; other site
290512001254	H-loop/switch region; other site
290512001255	putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814
290512001256	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
290512001257	catalytic loop [active]
290512001258	iron binding site [ion binding]; other site
290512001259	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290512001260	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
290512001261	LytB protein; Region: LYTB; cl00507
290512001262	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
290512001263	pteridine reductase; Provisional; Region: PRK09135
290512001264	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290512001265	NAD(P) binding site [chemical binding]; other site
290512001266	active site
290512001267	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
290512001268	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
290512001269	Walker A/P-loop; other site
290512001270	ATP binding site [chemical binding]; other site
290512001271	Q-loop/lid; other site
290512001272	ABC transporter signature motif; other site
290512001273	Walker B; other site
290512001274	D-loop; other site
290512001275	H-loop/switch region; other site
290512001276	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
290512001277	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
290512001278	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
290512001279	nucleotide binding pocket [chemical binding]; other site
290512001280	K-X-D-G motif; other site
290512001281	catalytic site [active]
290512001282	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
290512001283	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
290512001284	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
290512001285	Dimer interface [polypeptide binding]; other site
290512001286	BRCT sequence motif; other site
290512001287	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
290512001288	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
290512001289	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290512001290	S-adenosylmethionine binding site [chemical binding]; other site
290512001291	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
290512001292	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290512001293	HlyD family secretion protein; Region: HlyD_3; pfam13437
290512001294	Predicted permeases [General function prediction only]; Region: COG0679
290512001295	Uncharacterized conserved protein [Function unknown]; Region: COG1432
290512001296	LabA_like proteins; Region: LabA; cd10911
290512001297	putative metal binding site [ion binding]; other site
290512001298	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603
290512001299	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
290512001300	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
290512001301	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
290512001302	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290512001303	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
290512001304	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
290512001305	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
290512001306	FAD binding pocket [chemical binding]; other site
290512001307	FAD binding motif [chemical binding]; other site
290512001308	phosphate binding motif [ion binding]; other site
290512001309	beta-alpha-beta structure motif; other site
290512001310	NAD binding pocket [chemical binding]; other site
290512001311	Iron coordination center [ion binding]; other site
290512001312	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
290512001313	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
290512001314	putative active site [active]
290512001315	oxyanion strand; other site
290512001316	catalytic triad [active]
290512001317	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
290512001318	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
290512001319	catalytic residues [active]
290512001320	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
290512001321	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
290512001322	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
290512001323	RNA binding surface [nucleotide binding]; other site
290512001324	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
290512001325	active site
290512001326	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
290512001327	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
290512001328	Uncharacterized conserved protein [Function unknown]; Region: COG3586
290512001329	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
290512001330	Meiotically up-regulated gene 113; Region: MUG113; pfam13455
290512001331	Restriction endonuclease; Region: Mrr_cat; pfam04471
290512001332	AAA domain; Region: AAA_23; pfam13476
290512001333	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290512001334	Walker A/P-loop; other site
290512001335	ATP binding site [chemical binding]; other site
290512001336	AAA domain; Region: AAA_21; pfam13304
290512001337	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290512001338	ABC transporter signature motif; other site
290512001339	Walker B; other site
290512001340	D-loop; other site
290512001341	H-loop/switch region; other site
290512001342	Transposase; Region: HTH_Tnp_1; pfam01527
290512001343	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
290512001344	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
290512001345	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
290512001346	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
290512001347	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
290512001348	aminodeoxychorismate synthase; Provisional; Region: PRK07508
290512001349	chorismate binding enzyme; Region: Chorismate_bind; cl10555
290512001350	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
290512001351	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
290512001352	substrate-cofactor binding pocket; other site
290512001353	homodimer interface [polypeptide binding]; other site
290512001354	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290512001355	catalytic residue [active]
290512001356	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
290512001357	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
290512001358	minor groove reading motif; other site
290512001359	helix-hairpin-helix signature motif; other site
290512001360	substrate binding pocket [chemical binding]; other site
290512001361	active site
290512001362	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
290512001363	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
290512001364	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
290512001365	active site
290512001366	metal binding site [ion binding]; metal-binding site
290512001367	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
290512001368	putative RNA binding site [nucleotide binding]; other site
290512001369	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
290512001370	haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1
290512001371	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
290512001372	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
290512001373	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
290512001374	Walker A/P-loop; other site
290512001375	ATP binding site [chemical binding]; other site
290512001376	Q-loop/lid; other site
290512001377	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
290512001378	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
290512001379	ABC transporter signature motif; other site
290512001380	Walker B; other site
290512001381	D-loop; other site
290512001382	H-loop/switch region; other site
290512001383	dihydropteroate synthase; Region: DHPS; TIGR01496
290512001384	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
290512001385	substrate binding pocket [chemical binding]; other site
290512001386	dimer interface [polypeptide binding]; other site
290512001387	inhibitor binding site; inhibition site
290512001388	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
290512001389	Peptidase family M50; Region: Peptidase_M50; pfam02163
290512001390	active site
290512001391	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
290512001392	putative substrate binding region [chemical binding]; other site
290512001393	Haem-binding domain; Region: Haem_bd; pfam14376
290512001394	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
290512001395	hybrid cluster protein; Provisional; Region: PRK05290
290512001396	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
290512001397	ACS interaction site; other site
290512001398	CODH interaction site; other site
290512001399	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
290512001400	CODH interaction site; other site
290512001401	metal cluster binding site [ion binding]; other site
290512001402	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
290512001403	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
290512001404	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
290512001405	dimerization interface [polypeptide binding]; other site
290512001406	putative DNA binding site [nucleotide binding]; other site
290512001407	putative Zn2+ binding site [ion binding]; other site
290512001408	Predicted permeases [General function prediction only]; Region: COG0701
290512001409	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
290512001410	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
290512001411	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290512001412	motif II; other site
290512001413	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
290512001414	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
290512001415	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
290512001416	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
290512001417	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
290512001418	Pleckstrin homology-like domain; Region: PH-like; cl17171
290512001419	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
290512001420	pyruvate phosphate dikinase; Provisional; Region: PRK09279
290512001421	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
290512001422	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
290512001423	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
290512001424	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
290512001425	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
290512001426	TM-ABC transporter signature motif; other site
290512001427	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
290512001428	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
290512001429	conserved cys residue [active]
290512001430	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603
290512001431	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
290512001432	Isochorismatase family; Region: Isochorismatase; pfam00857
290512001433	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
290512001434	catalytic triad [active]
290512001435	dimer interface [polypeptide binding]; other site
290512001436	conserved cis-peptide bond; other site
290512001437	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
290512001438	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
290512001439	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
290512001440	putative acyl-acceptor binding pocket; other site
290512001441	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
290512001442	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
290512001443	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
290512001444	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
290512001445	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
290512001446	MPN+ (JAMM) motif; other site
290512001447	Zinc-binding site [ion binding]; other site
290512001448	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
290512001449	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
290512001450	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
290512001451	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
290512001452	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
290512001453	active site
290512001454	ribulose/triose binding site [chemical binding]; other site
290512001455	phosphate binding site [ion binding]; other site
290512001456	substrate (anthranilate) binding pocket [chemical binding]; other site
290512001457	product (indole) binding pocket [chemical binding]; other site
290512001458	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
290512001459	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
290512001460	substrate binding site [chemical binding]; other site
290512001461	hexamer interface [polypeptide binding]; other site
290512001462	metal binding site [ion binding]; metal-binding site
290512001463	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
290512001464	Surface antigen; Region: Bac_surface_Ag; pfam01103
290512001465	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
290512001466	DNA polymerase I; Provisional; Region: PRK05755
290512001467	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
290512001468	active site
290512001469	metal binding site 1 [ion binding]; metal-binding site
290512001470	putative 5' ssDNA interaction site; other site
290512001471	metal binding site 3; metal-binding site
290512001472	metal binding site 2 [ion binding]; metal-binding site
290512001473	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
290512001474	putative DNA binding site [nucleotide binding]; other site
290512001475	putative metal binding site [ion binding]; other site
290512001476	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
290512001477	active site
290512001478	catalytic site [active]
290512001479	substrate binding site [chemical binding]; other site
290512001480	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
290512001481	active site
290512001482	DNA binding site [nucleotide binding]
290512001483	catalytic site [active]
290512001484	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
290512001485	Prephenate dehydratase; Region: PDT; pfam00800
290512001486	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
290512001487	putative L-Phe binding site [chemical binding]; other site
290512001488	hypothetical protein; Validated; Region: PRK00110
290512001489	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
290512001490	active site
290512001491	putative DNA-binding cleft [nucleotide binding]; other site
290512001492	dimer interface [polypeptide binding]; other site
290512001493	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
290512001494	bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188
290512001495	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
290512001496	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
290512001497	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
290512001498	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
290512001499	active site
290512001500	dimerization interface [polypeptide binding]; other site
290512001501	TspO/MBR family; Region: TspO_MBR; pfam03073
290512001502	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
290512001503	acetyl-CoA synthetase; Provisional; Region: PRK00174
290512001504	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
290512001505	active site
290512001506	CoA binding site [chemical binding]; other site
290512001507	acyl-activating enzyme (AAE) consensus motif; other site
290512001508	AMP binding site [chemical binding]; other site
290512001509	acetate binding site [chemical binding]; other site
290512001510	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
290512001511	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
290512001512	HIGH motif; other site
290512001513	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
290512001514	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
290512001515	active site
290512001516	KMSKS motif; other site
290512001517	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
290512001518	tRNA binding surface [nucleotide binding]; other site
290512001519	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
290512001520	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
290512001521	RNase E interface [polypeptide binding]; other site
290512001522	trimer interface [polypeptide binding]; other site
290512001523	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
290512001524	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
290512001525	RNase E interface [polypeptide binding]; other site
290512001526	trimer interface [polypeptide binding]; other site
290512001527	active site
290512001528	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
290512001529	putative nucleic acid binding region [nucleotide binding]; other site
290512001530	G-X-X-G motif; other site
290512001531	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
290512001532	RNA binding site [nucleotide binding]; other site
290512001533	domain interface; other site
290512001534	Pantoate-beta-alanine ligase; Region: PanC; cd00560
290512001535	pantoate--beta-alanine ligase; Region: panC; TIGR00018
290512001536	active site
290512001537	ATP-binding site [chemical binding]; other site
290512001538	pantoate-binding site; other site
290512001539	HXXH motif; other site
290512001540	Predicted methyltransferases [General function prediction only]; Region: COG0313
290512001541	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
290512001542	putative SAM binding site [chemical binding]; other site
290512001543	putative homodimer interface [polypeptide binding]; other site
290512001544	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
290512001545	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
290512001546	Walker A/P-loop; other site
290512001547	ATP binding site [chemical binding]; other site
290512001548	Q-loop/lid; other site
290512001549	ABC transporter signature motif; other site
290512001550	Walker B; other site
290512001551	D-loop; other site
290512001552	H-loop/switch region; other site
290512001553	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
290512001554	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
290512001555	tandem repeat interface [polypeptide binding]; other site
290512001556	oligomer interface [polypeptide binding]; other site
290512001557	active site residues [active]
290512001558	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
290512001559	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
290512001560	tandem repeat interface [polypeptide binding]; other site
290512001561	oligomer interface [polypeptide binding]; other site
290512001562	active site residues [active]
290512001563	Predicted amidohydrolase [General function prediction only]; Region: COG0388
290512001564	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
290512001565	putative active site [active]
290512001566	catalytic triad [active]
290512001567	putative dimer interface [polypeptide binding]; other site
290512001568	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
290512001569	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
290512001570	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290512001571	Walker A motif; other site
290512001572	ATP binding site [chemical binding]; other site
290512001573	Walker B motif; other site
290512001574	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
290512001575	Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643
290512001576	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
290512001577	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290512001578	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
290512001579	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
290512001580	active site
290512001581	Int/Topo IB signature motif; other site
290512001582	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
290512001583	30S subunit binding site; other site
290512001584	HPr kinase/phosphorylase; Provisional; Region: PRK05428
290512001585	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
290512001586	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
290512001587	Hpr binding site; other site
290512001588	active site
290512001589	homohexamer subunit interaction site [polypeptide binding]; other site
290512001590	The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
290512001591	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
290512001592	peptide binding site [polypeptide binding]; other site
290512001593	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
290512001594	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290512001595	dimer interface [polypeptide binding]; other site
290512001596	conserved gate region; other site
290512001597	putative PBP binding loops; other site
290512001598	ABC-ATPase subunit interface; other site
290512001599	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
290512001600	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290512001601	Walker A motif; other site
290512001602	ATP binding site [chemical binding]; other site
290512001603	Walker B motif; other site
290512001604	arginine finger; other site
290512001605	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
290512001606	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
290512001607	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512001608	TPR motif; other site
290512001609	binding surface
290512001610	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512001611	binding surface
290512001612	TPR motif; other site
290512001613	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512001614	TPR motif; other site
290512001615	binding surface
290512001616	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512001617	TPR motif; other site
290512001618	binding surface
290512001619	TPR repeat; Region: TPR_11; pfam13414
290512001620	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512001621	binding surface
290512001622	TPR motif; other site
290512001623	TPR repeat; Region: TPR_11; pfam13414
290512001624	CRISPR associated protein Cas6; Region: Cas_Cas6; pfam01881
290512001625	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290512001626	S-adenosylmethionine binding site [chemical binding]; other site
290512001627	Predicted transcriptional regulator [Transcription]; Region: COG1959
290512001628	Transcriptional regulator; Region: Rrf2; pfam02082
290512001629	hybrid cluster protein; Provisional; Region: PRK05290
290512001630	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
290512001631	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
290512001632	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
290512001633	dimer interface [polypeptide binding]; other site
290512001634	PYR/PP interface [polypeptide binding]; other site
290512001635	TPP binding site [chemical binding]; other site
290512001636	substrate binding site [chemical binding]; other site
290512001637	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
290512001638	Domain of unknown function; Region: EKR; pfam10371
290512001639	4Fe-4S binding domain; Region: Fer4_6; pfam12837
290512001640	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
290512001641	TPP-binding site [chemical binding]; other site
290512001642	dimer interface [polypeptide binding]; other site
290512001643	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
290512001644	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
290512001645	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
290512001646	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
290512001647	lipoyl attachment site [posttranslational modification]; other site
290512001648	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
290512001649	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
290512001650	tetramer interface [polypeptide binding]; other site
290512001651	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290512001652	catalytic residue [active]
290512001653	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
290512001654	dihydrodipicolinate synthase; Region: dapA; TIGR00674
290512001655	dimer interface [polypeptide binding]; other site
290512001656	active site
290512001657	catalytic residue [active]
290512001658	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
290512001659	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
290512001660	Walker A/P-loop; other site
290512001661	ATP binding site [chemical binding]; other site
290512001662	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
290512001663	ABC transporter signature motif; other site
290512001664	Walker B; other site
290512001665	D-loop; other site
290512001666	H-loop/switch region; other site
290512001667	Lamin Tail Domain; Region: LTD; pfam00932
290512001668	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
290512001669	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
290512001670	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
290512001671	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
290512001672	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
290512001673	Ligand Binding Site [chemical binding]; other site
290512001674	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
290512001675	RNA/DNA hybrid binding site [nucleotide binding]; other site
290512001676	active site
290512001677	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
290512001678	bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566
290512001679	UbiA prenyltransferase family; Region: UbiA; pfam01040
290512001680	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
290512001681	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
290512001682	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
290512001683	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
290512001684	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
290512001685	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
290512001686	active site
290512001687	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
290512001688	DNA polymerase III subunit delta'; Validated; Region: PRK08485
290512001689	ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
290512001690	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
290512001691	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
290512001692	homodimer interface [polypeptide binding]; other site
290512001693	substrate-cofactor binding pocket; other site
290512001694	catalytic residue [active]
290512001695	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
290512001696	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
290512001697	active site
290512001698	ADP/pyrophosphate binding site [chemical binding]; other site
290512001699	dimerization interface [polypeptide binding]; other site
290512001700	allosteric effector site; other site
290512001701	fructose-1,6-bisphosphate binding site; other site
290512001702	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
290512001703	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290512001704	FtsX-like permease family; Region: FtsX; pfam02687
290512001705	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
290512001706	homotrimer interaction site [polypeptide binding]; other site
290512001707	zinc binding site [ion binding]; other site
290512001708	CDP-binding sites; other site
290512001709	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
290512001710	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
290512001711	heterodimer interface [polypeptide binding]; other site
290512001712	active site
290512001713	FMN binding site [chemical binding]; other site
290512001714	homodimer interface [polypeptide binding]; other site
290512001715	substrate binding site [chemical binding]; other site
290512001716	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290512001717	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
290512001718	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
290512001719	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
290512001720	putative active site [active]
290512001721	putative metal binding site [ion binding]; other site
290512001722	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
290512001723	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
290512001724	Ferritin-like domain; Region: Ferritin; pfam00210
290512001725	ferroxidase diiron center [ion binding]; other site
290512001726	flavodoxin FldA; Validated; Region: PRK09267
290512001727	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
290512001728	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
290512001729	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
290512001730	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
290512001731	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
290512001732	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
290512001733	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
290512001734	N-terminal plug; other site
290512001735	ligand-binding site [chemical binding]; other site
290512001736	Cytochrome c; Region: Cytochrom_C; pfam00034
290512001737	Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055
290512001738	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
290512001739	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
290512001740	N-terminal plug; other site
290512001741	ligand-binding site [chemical binding]; other site
290512001742	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
290512001743	putative active site [active]
290512001744	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
290512001745	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
290512001746	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
290512001747	putative active site [active]
290512001748	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
290512001749	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
290512001750	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
290512001751	N-terminal plug; other site
290512001752	ligand-binding site [chemical binding]; other site
290512001753	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
290512001754	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
290512001755	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
290512001756	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
290512001757	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
290512001758	FeoC like transcriptional regulator; Region: FeoC; pfam09012
290512001759	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
290512001760	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
290512001761	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
290512001762	FeoA domain; Region: FeoA; pfam04023
290512001763	benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224
290512001764	Protein of unknown function (DUF3793); Region: DUF3793; pfam12672
290512001765	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
290512001766	iron-sulfur cluster [ion binding]; other site
290512001767	[2Fe-2S] cluster binding site [ion binding]; other site
290512001768	Putative molybdenum carrier; Region: MoCo_carrier; pfam12694
290512001769	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
290512001770	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
290512001771	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
290512001772	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
290512001773	ATP-grasp domain; Region: ATP-grasp_4; cl17255
290512001774	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
290512001775	IMP binding site; other site
290512001776	dimer interface [polypeptide binding]; other site
290512001777	interdomain contacts; other site
290512001778	partial ornithine binding site; other site
290512001779	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
290512001780	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
290512001781	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
290512001782	dimerization interface [polypeptide binding]; other site
290512001783	active site
290512001784	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
290512001785	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
290512001786	dimer interface [polypeptide binding]; other site
290512001787	active site
290512001788	glycine-pyridoxal phosphate binding site [chemical binding]; other site
290512001789	folate binding site [chemical binding]; other site
290512001790	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
290512001791	DNA primase; Validated; Region: dnaG; PRK05667
290512001792	CHC2 zinc finger; Region: zf-CHC2; pfam01807
290512001793	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
290512001794	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
290512001795	active site
290512001796	metal binding site [ion binding]; metal-binding site
290512001797	interdomain interaction site; other site
290512001798	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
290512001799	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
290512001800	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
290512001801	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
290512001802	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
290512001803	Protein of unknown function (DUF3098); Region: DUF3098; pfam11297
290512001804	acetylornithine aminotransferase; Provisional; Region: PRK02627
290512001805	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
290512001806	inhibitor-cofactor binding pocket; inhibition site
290512001807	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290512001808	catalytic residue [active]
290512001809	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
290512001810	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
290512001811	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
290512001812	AIR carboxylase; Region: AIRC; pfam00731
290512001813	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
290512001814	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512001815	FeS/SAM binding site; other site
290512001816	HemN C-terminal domain; Region: HemN_C; pfam06969
290512001817	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
290512001818	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
290512001819	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
290512001820	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
290512001821	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
290512001822	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
290512001823	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
290512001824	ABC transporter; Region: ABC_tran_2; pfam12848
290512001825	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
290512001826	short chain dehydrogenase; Provisional; Region: PRK12829
290512001827	classical (c) SDRs; Region: SDR_c; cd05233
290512001828	NAD(P) binding site [chemical binding]; other site
290512001829	active site
290512001830	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
290512001831	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
290512001832	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
290512001833	Domain of unknown function (DUF1704); Region: DUF1704; pfam08014
290512001834	glutathione synthetase; Provisional; Region: PRK12458
290512001835	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
290512001836	ATP-grasp domain; Region: ATP-grasp_4; cl17255
290512001837	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
290512001838	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
290512001839	CoA-ligase; Region: Ligase_CoA; pfam00549
290512001840	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
290512001841	nucleoside/Zn binding site; other site
290512001842	dimer interface [polypeptide binding]; other site
290512001843	catalytic motif [active]
290512001844	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
290512001845	FMN binding site [chemical binding]; other site
290512001846	substrate binding site [chemical binding]; other site
290512001847	putative catalytic residue [active]
290512001848	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
290512001849	catalytic core [active]
290512001850	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
290512001851	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
290512001852	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
290512001853	active site
290512001854	dimer interface [polypeptide binding]; other site
290512001855	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
290512001856	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
290512001857	active site
290512001858	FMN binding site [chemical binding]; other site
290512001859	substrate binding site [chemical binding]; other site
290512001860	3Fe-4S cluster binding site [ion binding]; other site
290512001861	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
290512001862	domain interface; other site
290512001863	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
290512001864	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290512001865	Domain of unknown function (DUF4404); Region: DUF4404; pfam14357
290512001866	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
290512001867	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
290512001868	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290512001869	Walker A motif; other site
290512001870	ATP binding site [chemical binding]; other site
290512001871	Walker B motif; other site
290512001872	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
290512001873	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
290512001874	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
290512001875	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
290512001876	active site
290512001877	DNA binding site [nucleotide binding]
290512001878	Int/Topo IB signature motif; other site
290512001879	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
290512001880	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
290512001881	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
290512001882	NMT1/THI5 like; Region: NMT1; pfam09084
290512001883	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137
290512001884	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
290512001885	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290512001886	Walker A/P-loop; other site
290512001887	ATP binding site [chemical binding]; other site
290512001888	Q-loop/lid; other site
290512001889	ABC transporter signature motif; other site
290512001890	Walker B; other site
290512001891	D-loop; other site
290512001892	H-loop/switch region; other site
290512001893	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
290512001894	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290512001895	dimer interface [polypeptide binding]; other site
290512001896	conserved gate region; other site
290512001897	putative PBP binding loops; other site
290512001898	ABC-ATPase subunit interface; other site
290512001899	Methyltransferase domain; Region: Methyltransf_25; pfam13649
290512001900	Helix-turn-helix domain; Region: HTH_17; pfam12728
290512001901	ParA-like protein; Provisional; Region: PHA02518
290512001902	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
290512001903	P-loop; other site
290512001904	Magnesium ion binding site [ion binding]; other site
290512001905	conjugal transfer peptidase TraF; Provisional; Region: PRK13884
290512001906	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
290512001907	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
290512001908	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
290512001909	putative active site [active]
290512001910	putative NTP binding site [chemical binding]; other site
290512001911	putative nucleic acid binding site [nucleotide binding]; other site
290512001912	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
290512001913	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
290512001914	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
290512001915	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
290512001916	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
290512001917	nucleotide binding site/active site [active]
290512001918	HIT family signature motif; other site
290512001919	catalytic residue [active]
290512001920	RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248
290512001921	Thiamine monophosphate kinase [Coenzyme metabolism]; Region: ThiL; COG0611
290512001922	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
290512001923	ATP binding site [chemical binding]; other site
290512001924	dimerization interface [polypeptide binding]; other site
290512001925	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
290512001926	trimer interface [polypeptide binding]; other site
290512001927	active site
290512001928	Integrase core domain; Region: rve_3; pfam13683
290512001929	Homeodomain-like domain; Region: HTH_32; pfam13565
290512001930	Integrase core domain; Region: rve; pfam00665
290512001931	Transposase; Region: HTH_Tnp_1; cl17663
290512001932	Uncharacterized conserved protein [Function unknown]; Region: COG3472
290512001933	putative transposase OrfB; Reviewed; Region: PHA02517
290512001934	Homeodomain-like domain; Region: HTH_32; pfam13565
290512001935	Integrase core domain; Region: rve; pfam00665
290512001936	Integrase core domain; Region: rve_3; pfam13683
290512001937	Transposase; Region: HTH_Tnp_1; pfam01527
290512001938	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
290512001939	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
290512001940	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
290512001941	putative active site [active]
290512001942	putative NTP binding site [chemical binding]; other site
290512001943	putative nucleic acid binding site [nucleotide binding]; other site
290512001944	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
290512001945	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
290512001946	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
290512001947	Zn binding site [ion binding]; other site
290512001948	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
290512001949	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
290512001950	30S subunit binding site; other site
290512001951	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
290512001952	putative ligand binding site [chemical binding]; other site
290512001953	SnoaL-like domain; Region: SnoaL_3; pfam13474
290512001954	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
290512001955	Domain of unknown function (DUF4282); Region: DUF4282; pfam14110
290512001956	short chain dehydrogenase; Provisional; Region: PRK06197
290512001957	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
290512001958	putative NAD(P) binding site [chemical binding]; other site
290512001959	active site
290512001960	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
290512001961	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
290512001962	Helicase; Region: Helicase_RecD; pfam05127
290512001963	Family description; Region: UvrD_C_2; pfam13538
290512001964	ribonuclease R; Region: RNase_R; TIGR02063
290512001965	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
290512001966	RNB domain; Region: RNB; pfam00773
290512001967	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
290512001968	RNA binding site [nucleotide binding]; other site
290512001969	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
290512001970	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
290512001971	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290512001972	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290512001973	ATP binding site [chemical binding]; other site
290512001974	Mg2+ binding site [ion binding]; other site
290512001975	G-X-G motif; other site
290512001976	Response regulator receiver domain; Region: Response_reg; pfam00072
290512001977	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290512001978	active site
290512001979	phosphorylation site [posttranslational modification]
290512001980	intermolecular recognition site; other site
290512001981	dimerization interface [polypeptide binding]; other site
290512001982	Response regulator receiver domain; Region: Response_reg; pfam00072
290512001983	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290512001984	active site
290512001985	phosphorylation site [posttranslational modification]
290512001986	intermolecular recognition site; other site
290512001987	dimerization interface [polypeptide binding]; other site
290512001988	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
290512001989	putative binding surface; other site
290512001990	active site
290512001991	hypothetical protein; Provisional; Region: PRK07179
290512001992	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
290512001993	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
290512001994	catalytic residue [active]
290512001995	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
290512001996	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
290512001997	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290512001998	catalytic residue [active]
290512001999	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
290512002000	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
290512002001	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
290512002002	nucleophilic elbow; other site
290512002003	catalytic triad; other site
290512002004	Rrf2 family protein; Region: rrf2_super; TIGR00738
290512002005	Transcriptional regulator; Region: Rrf2; pfam02082
290512002006	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
290512002007	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
290512002008	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290512002009	ABC transporter signature motif; other site
290512002010	Walker B; other site
290512002011	D-loop; other site
290512002012	H-loop/switch region; other site
290512002013	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
290512002014	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
290512002015	oligomerisation interface [polypeptide binding]; other site
290512002016	mobile loop; other site
290512002017	roof hairpin; other site
290512002018	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
290512002019	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
290512002020	ring oligomerisation interface [polypeptide binding]; other site
290512002021	ATP/Mg binding site [chemical binding]; other site
290512002022	stacking interactions; other site
290512002023	hinge regions; other site
290512002024	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
290512002025	Ligand Binding Site [chemical binding]; other site
290512002026	CAAX protease self-immunity; Region: Abi; pfam02517
290512002027	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
290512002028	substrate binding site [chemical binding]; other site
290512002029	active site
290512002030	catalytic residues [active]
290512002031	heterodimer interface [polypeptide binding]; other site
290512002032	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
290512002033	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
290512002034	Probable Catalytic site; other site
290512002035	metal-binding site
290512002036	cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662
290512002037	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
290512002038	NADP binding site [chemical binding]; other site
290512002039	putative substrate binding site [chemical binding]; other site
290512002040	active site
290512002041	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866
290512002042	putative hydrophobic ligand binding site [chemical binding]; other site
290512002043	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866
290512002044	putative hydrophobic ligand binding site [chemical binding]; other site
290512002045	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290512002046	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
290512002047	putative substrate translocation pore; other site
290512002048	S-adenosylmethionine synthetase (AdoMet synthetase); Region: AdoMet_Synthase; pfam01941
290512002049	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
290512002050	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
290512002051	rod shape-determining protein MreB; Provisional; Region: PRK13930
290512002052	MreB and similar proteins; Region: MreB_like; cd10225
290512002053	nucleotide binding site [chemical binding]; other site
290512002054	Mg binding site [ion binding]; other site
290512002055	putative protofilament interaction site [polypeptide binding]; other site
290512002056	RodZ interaction site [polypeptide binding]; other site
290512002057	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
290512002058	histidinol dehydrogenase; Region: hisD; TIGR00069
290512002059	NAD binding site [chemical binding]; other site
290512002060	dimerization interface [polypeptide binding]; other site
290512002061	product binding site; other site
290512002062	substrate binding site [chemical binding]; other site
290512002063	zinc binding site [ion binding]; other site
290512002064	catalytic residues [active]
290512002065	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
290512002066	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
290512002067	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
290512002068	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
290512002069	substrate binding site [chemical binding]; other site
290512002070	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
290512002071	substrate binding site [chemical binding]; other site
290512002072	ligand binding site [chemical binding]; other site
290512002073	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
290512002074	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
290512002075	hinge; other site
290512002076	active site
290512002077	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
290512002078	Peptidase family M23; Region: Peptidase_M23; pfam01551
290512002079	NAD synthetase; Provisional; Region: PRK13980
290512002080	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
290512002081	homodimer interface [polypeptide binding]; other site
290512002082	NAD binding pocket [chemical binding]; other site
290512002083	ATP binding pocket [chemical binding]; other site
290512002084	Mg binding site [ion binding]; other site
290512002085	active-site loop [active]
290512002086	L-aspartate oxidase; Provisional; Region: PRK09077
290512002087	L-aspartate oxidase; Provisional; Region: PRK06175
290512002088	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
290512002089	Domain of unknown function (DUF368); Region: DUF368; pfam04018
290512002090	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
290512002091	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
290512002092	pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285
290512002093	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
290512002094	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
290512002095	active site
290512002096	HIGH motif; other site
290512002097	dimer interface [polypeptide binding]; other site
290512002098	KMSKS motif; other site
290512002099	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
290512002100	RNA binding surface [nucleotide binding]; other site
290512002101	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
290512002102	SmpB-tmRNA interface; other site
290512002103	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
290512002104	FAD binding domain; Region: FAD_binding_4; pfam01565
290512002105	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
290512002106	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
290512002107	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
290512002108	rod shape-determining protein MreC; Provisional; Region: PRK13922
290512002109	rod shape-determining protein MreC; Region: MreC; pfam04085
290512002110	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
290512002111	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
290512002112	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
290512002113	oligomerisation interface [polypeptide binding]; other site
290512002114	mobile loop; other site
290512002115	roof hairpin; other site
290512002116	Quinolinate synthetase A protein; Region: NadA; pfam02445
290512002117	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
290512002118	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
290512002119	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
290512002120	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
290512002121	active site
290512002122	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
290512002123	TSCPD domain; Region: TSCPD; pfam12637
290512002124	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
290512002125	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290512002126	Walker A/P-loop; other site
290512002127	ATP binding site [chemical binding]; other site
290512002128	Q-loop/lid; other site
290512002129	ABC transporter signature motif; other site
290512002130	Walker B; other site
290512002131	D-loop; other site
290512002132	H-loop/switch region; other site
290512002133	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
290512002134	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
290512002135	Domain of unknown function (DUF4293); Region: DUF4293; pfam14126
290512002136	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
290512002137	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290512002138	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
290512002139	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
290512002140	ATP binding site [chemical binding]; other site
290512002141	Mg++ binding site [ion binding]; other site
290512002142	motif III; other site
290512002143	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290512002144	nucleotide binding region [chemical binding]; other site
290512002145	ATP-binding site [chemical binding]; other site
290512002146	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
290512002147	putative RNA binding site [nucleotide binding]; other site
290512002148	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
290512002149	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
290512002150	putative metal binding site [ion binding]; other site
290512002151	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
290512002152	putative catalytic site [active]
290512002153	putative phosphate binding site [ion binding]; other site
290512002154	putative metal binding site [ion binding]; other site
290512002155	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
290512002156	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
290512002157	Beta-Casp domain; Region: Beta-Casp; smart01027
290512002158	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
290512002159	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
290512002160	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
290512002161	active site
290512002162	Int/Topo IB signature motif; other site
290512002163	16S rRNA methyltransferase B; Provisional; Region: PRK14904
290512002164	NusB family; Region: NusB; pfam01029
290512002165	putative RNA binding site [nucleotide binding]; other site
290512002166	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
290512002167	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
290512002168	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
290512002169	homodimer interface [polypeptide binding]; other site
290512002170	substrate-cofactor binding pocket; other site
290512002171	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290512002172	catalytic residue [active]
290512002173	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
290512002174	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
290512002175	seryl-tRNA synthetase; Provisional; Region: PRK05431
290512002176	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
290512002177	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
290512002178	dimer interface [polypeptide binding]; other site
290512002179	active site
290512002180	motif 1; other site
290512002181	motif 2; other site
290512002182	motif 3; other site
290512002183	Yqey-like protein; Region: YqeY; pfam09424
290512002184	classical (c) SDRs; Region: SDR_c; cd05233
290512002185	NAD(P) binding site [chemical binding]; other site
290512002186	active site
290512002187	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
290512002188	DNA-binding site [nucleotide binding]; DNA binding site
290512002189	RNA-binding motif; other site
290512002190	hypothetical protein; Reviewed; Region: PRK00024
290512002191	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
290512002192	MPN+ (JAMM) motif; other site
290512002193	Zinc-binding site [ion binding]; other site
290512002194	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
290512002195	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
290512002196	active site
290512002197	catalytic residues [active]
290512002198	metal binding site [ion binding]; metal-binding site
290512002199	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
290512002200	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
290512002201	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
290512002202	substrate binding site [chemical binding]; other site
290512002203	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
290512002204	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
290512002205	substrate binding site [chemical binding]; other site
290512002206	ligand binding site [chemical binding]; other site
290512002207	2-isopropylmalate synthase; Validated; Region: PRK00915
290512002208	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
290512002209	active site
290512002210	catalytic residues [active]
290512002211	metal binding site [ion binding]; metal-binding site
290512002212	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
290512002213	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
290512002214	tartrate dehydrogenase; Region: TTC; TIGR02089
290512002215	ketol-acid reductoisomerase; Provisional; Region: PRK05479
290512002216	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
290512002217	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
290512002218	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
290512002219	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
290512002220	putative valine binding site [chemical binding]; other site
290512002221	dimer interface [polypeptide binding]; other site
290512002222	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
290512002223	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
290512002224	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
290512002225	PYR/PP interface [polypeptide binding]; other site
290512002226	dimer interface [polypeptide binding]; other site
290512002227	TPP binding site [chemical binding]; other site
290512002228	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
290512002229	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
290512002230	TPP-binding site [chemical binding]; other site
290512002231	dimer interface [polypeptide binding]; other site
290512002232	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
290512002233	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
290512002234	Integral membrane protein DUF92; Region: DUF92; pfam01940
290512002235	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
290512002236	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
290512002237	TolR protein; Region: tolR; TIGR02801
290512002238	TonB C terminal; Region: TonB_2; pfam13103
290512002239	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
290512002240	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
290512002241	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
290512002242	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
290512002243	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
290512002244	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
290512002245	ligand binding site [chemical binding]; other site
290512002246	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
290512002247	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
290512002248	ligand binding site [chemical binding]; other site
290512002249	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
290512002250	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512002251	binding surface
290512002252	TPR motif; other site
290512002253	Photosystem P840 reaction centre protein PscD; Region: RC-P840_PscD; pfam10657
290512002254	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
290512002255	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
290512002256	nucleotide binding site [chemical binding]; other site
290512002257	NEF interaction site [polypeptide binding]; other site
290512002258	SBD interface [polypeptide binding]; other site
290512002259	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
290512002260	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
290512002261	putative dimer interface [polypeptide binding]; other site
290512002262	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
290512002263	dimerization interface [polypeptide binding]; other site
290512002264	putative DNA binding site [nucleotide binding]; other site
290512002265	putative Zn2+ binding site [ion binding]; other site
290512002266	Putative zinc-finger; Region: zf-HC2; pfam13490
290512002267	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
290512002268	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290512002269	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290512002270	DNA binding residues [nucleotide binding]
290512002271	carotene isomerase; Region: carot_isom; TIGR02730
290512002272	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290512002273	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
290512002274	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
290512002275	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
290512002276	hexamer interface [polypeptide binding]; other site
290512002277	ligand binding site [chemical binding]; other site
290512002278	putative active site [active]
290512002279	NAD(P) binding site [chemical binding]; other site
290512002280	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
290512002281	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
290512002282	catalytic loop [active]
290512002283	iron binding site [ion binding]; other site
290512002284	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
290512002285	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
290512002286	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
290512002287	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
290512002288	catalytic loop [active]
290512002289	iron binding site [ion binding]; other site
290512002290	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
290512002291	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
290512002292	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290512002293	ATP binding site [chemical binding]; other site
290512002294	putative Mg++ binding site [ion binding]; other site
290512002295	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290512002296	nucleotide binding region [chemical binding]; other site
290512002297	ATP-binding site [chemical binding]; other site
290512002298	TRCF domain; Region: TRCF; pfam03461
290512002299	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
290512002300	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
290512002301	Walker A/P-loop; other site
290512002302	ATP binding site [chemical binding]; other site
290512002303	Q-loop/lid; other site
290512002304	ABC transporter signature motif; other site
290512002305	Walker B; other site
290512002306	D-loop; other site
290512002307	H-loop/switch region; other site
290512002308	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
290512002309	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
290512002310	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290512002311	active site
290512002312	phosphorylation site [posttranslational modification]
290512002313	intermolecular recognition site; other site
290512002314	dimerization interface [polypeptide binding]; other site
290512002315	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
290512002316	DNA binding site [nucleotide binding]
290512002317	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
290512002318	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290512002319	dimerization interface [polypeptide binding]; other site
290512002320	PAS domain; Region: PAS; smart00091
290512002321	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
290512002322	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290512002323	dimer interface [polypeptide binding]; other site
290512002324	phosphorylation site [posttranslational modification]
290512002325	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290512002326	ATP binding site [chemical binding]; other site
290512002327	Mg2+ binding site [ion binding]; other site
290512002328	G-X-G motif; other site
290512002329	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
290512002330	Mechanosensitive ion channel; Region: MS_channel; pfam00924
290512002331	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
290512002332	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
290512002333	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
290512002334	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
290512002335	nudix motif; other site
290512002336	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
290512002337	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
290512002338	catalytic triad [active]
290512002339	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
290512002340	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
290512002341	putative addiction module antidote; Region: doc_partner; TIGR02609
290512002342	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002343	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002344	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002345	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002346	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002347	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002348	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002349	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002350	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002351	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002352	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002353	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002354	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002355	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002356	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002357	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002358	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002359	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002360	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002361	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002362	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002363	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002364	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002365	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002366	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002367	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002368	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002369	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
290512002370	metal ion-dependent adhesion site (MIDAS); other site
290512002371	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002372	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002373	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002374	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002375	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002376	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002377	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002378	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002379	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290512002380	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
290512002381	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421
290512002382	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
290512002383	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
290512002384	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
290512002385	Walker A/P-loop; other site
290512002386	ATP binding site [chemical binding]; other site
290512002387	Q-loop/lid; other site
290512002388	ABC transporter signature motif; other site
290512002389	Walker B; other site
290512002390	D-loop; other site
290512002391	H-loop/switch region; other site
290512002392	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
290512002393	HlyD family secretion protein; Region: HlyD_3; pfam13437
290512002394	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
290512002395	active site
290512002396	8-oxo-dGMP binding site [chemical binding]; other site
290512002397	nudix motif; other site
290512002398	metal binding site [ion binding]; metal-binding site
290512002399	Protein of unknown function DUF45; Region: DUF45; pfam01863
290512002400	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
290512002401	trimer interface [polypeptide binding]; other site
290512002402	putative Zn binding site [ion binding]; other site
290512002403	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
290512002404	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
290512002405	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290512002406	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
290512002407	HlyD family secretion protein; Region: HlyD_3; pfam13437
290512002408	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
290512002409	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
290512002410	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
290512002411	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
290512002412	phytoene desaturase; Region: crtI_fam; TIGR02734
290512002413	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290512002414	Mechanosensitive ion channel; Region: MS_channel; pfam00924
290512002415	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
290512002416	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
290512002417	Coenzyme A binding pocket [chemical binding]; other site
290512002418	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
290512002419	Na binding site [ion binding]; other site
290512002420	lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820
290512002421	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512002422	FeS/SAM binding site; other site
290512002423	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
290512002424	Transcriptional regulators [Transcription]; Region: MarR; COG1846
290512002425	MarR family; Region: MarR_2; cl17246
290512002426	MarR family; Region: MarR_2; cl17246
290512002427	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
290512002428	active site
290512002429	Adenosylhomocysteinase; Provisional; Region: PTZ00075
290512002430	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
290512002431	homotetramer interface [polypeptide binding]; other site
290512002432	ligand binding site [chemical binding]; other site
290512002433	catalytic site [active]
290512002434	NAD binding site [chemical binding]; other site
290512002435	S-adenosylmethionine synthetase; Validated; Region: PRK05250
290512002436	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
290512002437	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
290512002438	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
290512002439	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
290512002440	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
290512002441	active site
290512002442	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
290512002443	N-terminal domain interface [polypeptide binding]; other site
290512002444	sulfate 1 binding site; other site
290512002445	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
290512002446	nudix motif; other site
290512002447	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
290512002448	MarR family; Region: MarR_2; pfam12802
290512002449	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290512002450	HlyD family secretion protein; Region: HlyD_3; pfam13437
290512002451	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
290512002452	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
290512002453	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
290512002454	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
290512002455	putative tRNA-binding site [nucleotide binding]; other site
290512002456	B3/4 domain; Region: B3_4; pfam03483
290512002457	tRNA synthetase B5 domain; Region: B5; pfam03484
290512002458	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
290512002459	dimer interface [polypeptide binding]; other site
290512002460	motif 1; other site
290512002461	motif 3; other site
290512002462	motif 2; other site
290512002463	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
290512002464	Cell division protein ZapA; Region: ZapA; pfam05164
290512002465	phosphodiesterase; Provisional; Region: PRK12704
290512002466	KH domain; Region: KH_1; pfam00013
290512002467	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
290512002468	Zn2+ binding site [ion binding]; other site
290512002469	Mg2+ binding site [ion binding]; other site
290512002470	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
290512002471	putative active site pocket [active]
290512002472	4-fold oligomerization interface [polypeptide binding]; other site
290512002473	metal binding residues [ion binding]; metal-binding site
290512002474	3-fold/trimer interface [polypeptide binding]; other site
290512002475	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
290512002476	protein translocase, SecG subunit; Region: secG; TIGR00810
290512002477	Alginate lyase; Region: Alginate_lyase; pfam05426
290512002478	Alginate lyase; Region: Alginate_lyase; pfam05426
290512002479	Predicted permeases [General function prediction only]; Region: COG0795
290512002480	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
290512002481	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
290512002482	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
290512002483	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
290512002484	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
290512002485	Domain of unknown function (DUF814); Region: DUF814; pfam05670
290512002486	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
290512002487	catalytic motif [active]
290512002488	Zn binding site [ion binding]; other site
290512002489	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
290512002490	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
290512002491	catalytic motif [active]
290512002492	Zn binding site [ion binding]; other site
290512002493	RibD C-terminal domain; Region: RibD_C; cl17279
290512002494	Predicted membrane protein [Function unknown]; Region: COG2259
290512002495	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
290512002496	dimer interface [polypeptide binding]; other site
290512002497	catalytic triad [active]
290512002498	peroxidatic and resolving cysteines [active]
290512002499	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
290512002500	Lumazine binding domain; Region: Lum_binding; pfam00677
290512002501	Lumazine binding domain; Region: Lum_binding; pfam00677
290512002502	recombination factor protein RarA; Reviewed; Region: PRK13342
290512002503	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290512002504	Walker A motif; other site
290512002505	ATP binding site [chemical binding]; other site
290512002506	Walker B motif; other site
290512002507	arginine finger; other site
290512002508	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
290512002509	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
290512002510	universal stress protein UspE; Provisional; Region: PRK11175
290512002511	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290512002512	Ligand Binding Site [chemical binding]; other site
290512002513	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290512002514	Ligand Binding Site [chemical binding]; other site
290512002515	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
290512002516	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
290512002517	TrkA-N domain; Region: TrkA_N; pfam02254
290512002518	Methyltransferase domain; Region: Methyltransf_23; pfam13489
290512002519	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290512002520	S-adenosylmethionine binding site [chemical binding]; other site
290512002521	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
290512002522	nucleotide binding site/active site [active]
290512002523	HIT family signature motif; other site
290512002524	catalytic residue [active]
290512002525	Ferrochelatase; Region: Ferrochelatase; pfam00762
290512002526	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
290512002527	C-terminal domain interface [polypeptide binding]; other site
290512002528	active site
290512002529	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
290512002530	active site
290512002531	N-terminal domain interface [polypeptide binding]; other site
290512002532	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512002533	binding surface
290512002534	TPR motif; other site
290512002535	TPR repeat; Region: TPR_11; pfam13414
290512002536	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
290512002537	NADH dehydrogenase subunit B; Provisional; Region: PRK14813
290512002538	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
290512002539	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
290512002540	NADH dehydrogenase subunit D; Validated; Region: PRK06075
290512002541	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
290512002542	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
290512002543	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
290512002544	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
290512002545	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
290512002546	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
290512002547	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
290512002548	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
290512002549	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
290512002550	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
290512002551	proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972
290512002552	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
290512002553	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
290512002554	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
290512002555	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
290512002556	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
290512002557	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
290512002558	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
290512002559	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
290512002560	Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125
290512002561	transcription termination factor Rho; Provisional; Region: PRK12678
290512002562	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
290512002563	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
290512002564	putative substrate-binding site; other site
290512002565	nickel binding site [ion binding]; other site
290512002566	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
290512002567	Domain of unknown function DUF20; Region: UPF0118; pfam01594
290512002568	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
290512002569	homodecamer interface [polypeptide binding]; other site
290512002570	GTP cyclohydrolase I; Provisional; Region: PLN03044
290512002571	active site
290512002572	putative catalytic site residues [active]
290512002573	zinc binding site [ion binding]; other site
290512002574	GTP-CH-I/GFRP interaction surface; other site
290512002575	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
290512002576	active site
290512002577	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
290512002578	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
290512002579	catalytic residues [active]
290512002580	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
290512002581	putative hydrophobic ligand binding site [chemical binding]; other site
290512002582	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603
290512002583	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
290512002584	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359
290512002585	putative dimer interface [polypeptide binding]; other site
290512002586	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
290512002587	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
290512002588	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290512002589	motif II; other site
290512002590	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603
290512002591	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
290512002592	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
290512002593	dimer interface [polypeptide binding]; other site
290512002594	active site residues [active]
290512002595	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
290512002596	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
290512002597	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
290512002598	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290512002599	Ligand Binding Site [chemical binding]; other site
290512002600	membrane ATPase/protein kinase; Provisional; Region: PRK09435
290512002601	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
290512002602	Walker A; other site
290512002603	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
290512002604	G4 box; other site
290512002605	G5 box; other site
290512002606	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
290512002607	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
290512002608	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
290512002609	active site
290512002610	substrate binding site [chemical binding]; other site
290512002611	coenzyme B12 binding site [chemical binding]; other site
290512002612	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
290512002613	B12 binding site [chemical binding]; other site
290512002614	cobalt ligand [ion binding]; other site
290512002615	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
290512002616	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
290512002617	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
290512002618	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
290512002619	dimer interface [polypeptide binding]; other site
290512002620	substrate binding site [chemical binding]; other site
290512002621	metal binding site [ion binding]; metal-binding site
290512002622	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
290512002623	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
290512002624	acyl-activating enzyme (AAE) consensus motif; other site
290512002625	putative AMP binding site [chemical binding]; other site
290512002626	putative active site [active]
290512002627	putative CoA binding site [chemical binding]; other site
290512002628	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
290512002629	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290512002630	S-adenosylmethionine binding site [chemical binding]; other site
290512002631	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
290512002632	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
290512002633	PYR/PP interface [polypeptide binding]; other site
290512002634	dimer interface [polypeptide binding]; other site
290512002635	TPP binding site [chemical binding]; other site
290512002636	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
290512002637	hypothetical protein; Provisional; Region: PRK14621
290512002638	recombination protein RecR; Reviewed; Region: recR; PRK00076
290512002639	RecR protein; Region: RecR; pfam02132
290512002640	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
290512002641	putative active site [active]
290512002642	putative metal-binding site [ion binding]; other site
290512002643	tetramer interface [polypeptide binding]; other site
290512002644	phytoene desaturase; Region: phytoene_desat; TIGR02731
290512002645	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290512002646	AAA domain; Region: AAA_23; pfam13476
290512002647	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290512002648	AAA domain; Region: AAA_21; pfam13304
290512002649	Walker A/P-loop; other site
290512002650	ATP binding site [chemical binding]; other site
290512002651	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
290512002652	putative active site [active]
290512002653	putative metal-binding site [ion binding]; other site
290512002654	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512002655	binding surface
290512002656	TPR motif; other site
290512002657	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512002658	binding surface
290512002659	TPR motif; other site
290512002660	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512002661	binding surface
290512002662	Tetratricopeptide repeat; Region: TPR_16; pfam13432
290512002663	TPR motif; other site
290512002664	Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063
290512002665	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512002666	binding surface
290512002667	TPR motif; other site
290512002668	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290512002669	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512002670	binding surface
290512002671	TPR motif; other site
290512002672	alternate F1F0 ATPase, F1 subunit beta; Region: alt_F1F0_F1_bet; TIGR03305
290512002673	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
290512002674	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
290512002675	alpha subunit interaction interface [polypeptide binding]; other site
290512002676	Walker A motif; other site
290512002677	ATP binding site [chemical binding]; other site
290512002678	Walker B motif; other site
290512002679	inhibitor binding site; inhibition site
290512002680	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
290512002681	F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228
290512002682	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cl10033
290512002683	epsilon subunit interface [polypeptide binding]; other site
290512002684	LBP interface [polypeptide binding]; other site
290512002685	gamma subunit interface [polypeptide binding]; other site
290512002686	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
290512002687	N-ATPase, AtpR subunit; Region: AtpR; pfam12966
290512002688	alternate F1F0 ATPase, F0 subunit A; Region: altF1_A; TIGR03306
290512002689	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
290512002690	alternate F1F0 ATPase, F0 subunit C; Region: alt_F1F0_F0_C; TIGR03322
290512002691	alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321
290512002692	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
290512002693	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
290512002694	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
290512002695	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
290512002696	beta subunit interaction interface [polypeptide binding]; other site
290512002697	Walker A motif; other site
290512002698	ATP binding site [chemical binding]; other site
290512002699	Walker B motif; other site
290512002700	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
290512002701	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
290512002702	core domain interface [polypeptide binding]; other site
290512002703	delta subunit interface [polypeptide binding]; other site
290512002704	epsilon subunit interface [polypeptide binding]; other site
290512002705	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
290512002706	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
290512002707	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290512002708	S-adenosylmethionine binding site [chemical binding]; other site
290512002709	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
290512002710	active site
290512002711	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
290512002712	catalytic tetrad [active]
290512002713	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
290512002714	putative transporter; Provisional; Region: PRK11660
290512002715	Sulfate transporter family; Region: Sulfate_transp; pfam00916
290512002716	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
290512002717	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
290512002718	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
290512002719	G1 box; other site
290512002720	putative GEF interaction site [polypeptide binding]; other site
290512002721	GTP/Mg2+ binding site [chemical binding]; other site
290512002722	Switch I region; other site
290512002723	G2 box; other site
290512002724	G3 box; other site
290512002725	Switch II region; other site
290512002726	G4 box; other site
290512002727	G5 box; other site
290512002728	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
290512002729	phosphoglucomutase; Validated; Region: PRK07564
290512002730	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
290512002731	active site
290512002732	substrate binding site [chemical binding]; other site
290512002733	metal binding site [ion binding]; metal-binding site
290512002734	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
290512002735	dimer interface [polypeptide binding]; other site
290512002736	substrate binding site [chemical binding]; other site
290512002737	metal binding sites [ion binding]; metal-binding site
290512002738	fumarate hydratase; Reviewed; Region: fumC; PRK00485
290512002739	Class II fumarases; Region: Fumarase_classII; cd01362
290512002740	active site
290512002741	tetramer interface [polypeptide binding]; other site
290512002742	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
290512002743	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
290512002744	ATP cone domain; Region: ATP-cone; pfam03477
290512002745	Class III ribonucleotide reductase; Region: RNR_III; cd01675
290512002746	effector binding site; other site
290512002747	active site
290512002748	Zn binding site [ion binding]; other site
290512002749	glycine loop; other site
290512002750	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
290512002751	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
290512002752	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
290512002753	ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573
290512002754	dimerization interface [polypeptide binding]; other site
290512002755	active site
290512002756	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
290512002757	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
290512002758	NeuB family; Region: NeuB; pfam03102
290512002759	heat shock protein 90; Provisional; Region: PRK05218
290512002760	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290512002761	ATP binding site [chemical binding]; other site
290512002762	Mg2+ binding site [ion binding]; other site
290512002763	G-X-G motif; other site
290512002764	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
290512002765	diiron binding motif [ion binding]; other site
290512002766	CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431
290512002767	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
290512002768	AAA domain; Region: AAA_33; pfam13671
290512002769	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
290512002770	active site
290512002771	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290512002772	Ligand Binding Site [chemical binding]; other site
290512002773	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
290512002774	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
290512002775	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
290512002776	active site
290512002777	catalytic residues [active]
290512002778	metal binding site [ion binding]; metal-binding site
290512002779	homodimer binding site [polypeptide binding]; other site
290512002780	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
290512002781	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
290512002782	carboxyltransferase (CT) interaction site; other site
290512002783	biotinylation site [posttranslational modification]; other site
290512002784	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
290512002785	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
290512002786	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
290512002787	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
290512002788	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
290512002789	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
290512002790	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
290512002791	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
290512002792	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
290512002793	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
290512002794	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290512002795	putative ADP-binding pocket [chemical binding]; other site
290512002796	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
290512002797	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
290512002798	active site
290512002799	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
290512002800	generic binding surface II; other site
290512002801	generic binding surface I; other site
290512002802	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
290512002803	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
290512002804	catalytic residues [active]
290512002805	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
290512002806	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
290512002807	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
290512002808	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
290512002809	nudix motif; other site
290512002810	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290512002811	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290512002812	active site
290512002813	phosphorylation site [posttranslational modification]
290512002814	intermolecular recognition site; other site
290512002815	dimerization interface [polypeptide binding]; other site
290512002816	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290512002817	Walker A motif; other site
290512002818	ATP binding site [chemical binding]; other site
290512002819	Walker B motif; other site
290512002820	arginine finger; other site
290512002821	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290512002822	valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419
290512002823	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
290512002824	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
290512002825	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
290512002826	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
290512002827	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
290512002828	putative active site [active]
290512002829	putative metal binding site [ion binding]; other site
290512002830	SdiA-regulated; Region: SdiA-regulated; cd09971
290512002831	putative active site [active]
290512002832	Surface antigen; Region: Bac_surface_Ag; pfam01103
290512002833	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
290512002834	cyclase homology domain; Region: CHD; cd07302
290512002835	nucleotidyl binding site; other site
290512002836	metal binding site [ion binding]; metal-binding site
290512002837	dimer interface [polypeptide binding]; other site
290512002838	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
290512002839	Zn2+ binding site [ion binding]; other site
290512002840	Mg2+ binding site [ion binding]; other site
290512002841	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
290512002842	active site
290512002843	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
290512002844	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290512002845	motif II; other site
290512002846	Methyltransferase domain; Region: Methyltransf_31; pfam13847
290512002847	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290512002848	S-adenosylmethionine binding site [chemical binding]; other site
290512002849	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
290512002850	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
290512002851	putative acyl-acceptor binding pocket; other site
290512002852	PBP superfamily domain; Region: PBP_like_2; cl17296
290512002853	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
290512002854	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
290512002855	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290512002856	conserved gate region; other site
290512002857	putative PBP binding loops; other site
290512002858	ABC-ATPase subunit interface; other site
290512002859	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
290512002860	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290512002861	dimer interface [polypeptide binding]; other site
290512002862	conserved gate region; other site
290512002863	putative PBP binding loops; other site
290512002864	ABC-ATPase subunit interface; other site
290512002865	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14275
290512002866	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
290512002867	Walker A/P-loop; other site
290512002868	ATP binding site [chemical binding]; other site
290512002869	Q-loop/lid; other site
290512002870	ABC transporter signature motif; other site
290512002871	Walker B; other site
290512002872	D-loop; other site
290512002873	H-loop/switch region; other site
290512002874	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
290512002875	PhoU domain; Region: PhoU; pfam01895
290512002876	PhoU domain; Region: PhoU; pfam01895
290512002877	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
290512002878	PhoU domain; Region: PhoU; pfam01895
290512002879	DoxX-like family; Region: DoxX_3; pfam13781
290512002880	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
290512002881	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290512002882	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
290512002883	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290512002884	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
290512002885	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290512002886	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
290512002887	active site
290512002888	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
290512002889	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
290512002890	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
290512002891	FAD binding domain; Region: FAD_binding_4; pfam01565
290512002892	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
290512002893	Cysteine-rich domain; Region: CCG; pfam02754
290512002894	selenobiotic family peptide radical SAM maturase; Region: rSAM_for_selen; TIGR04082
290512002895	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512002896	FeS/SAM binding site; other site
290512002897	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
290512002898	aspartate aminotransferase; Provisional; Region: PRK08636
290512002899	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290512002900	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290512002901	homodimer interface [polypeptide binding]; other site
290512002902	catalytic residue [active]
290512002903	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
290512002904	hypothetical protein; Provisional; Region: PRK08609
290512002905	active site
290512002906	primer binding site [nucleotide binding]; other site
290512002907	NTP  binding site [chemical binding]; other site
290512002908	metal binding triad [ion binding]; metal-binding site
290512002909	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
290512002910	active site
290512002911	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
290512002912	von Willebrand factor type A domain; Region: VWA_2; pfam13519
290512002913	metal ion-dependent adhesion site (MIDAS); other site
290512002914	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
290512002915	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
290512002916	Coenzyme A binding pocket [chemical binding]; other site
290512002917	Protein of unknown function (DUF616); Region: DUF616; pfam04765
290512002918	Domain of unknown function (DUF397); Region: DUF397; pfam04149
290512002919	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
290512002920	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
290512002921	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
290512002922	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
290512002923	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
290512002924	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
290512002925	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
290512002926	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290512002927	active site
290512002928	motif I; other site
290512002929	motif II; other site
290512002930	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
290512002931	UbiA prenyltransferase family; Region: UbiA; pfam01040
290512002932	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
290512002933	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
290512002934	Putative methyltransferase; Region: Methyltransf_4; cl17290
290512002935	heat shock protein HtpX; Provisional; Region: PRK05457
290512002936	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
290512002937	active site
290512002938	catalytic site [active]
290512002939	substrate binding site [chemical binding]; other site
290512002940	SWIM zinc finger; Region: SWIM; pfam04434
290512002941	CAAX protease self-immunity; Region: Abi; pfam02517
290512002942	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
290512002943	trimer interface [polypeptide binding]; other site
290512002944	putative Zn binding site [ion binding]; other site
290512002945	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
290512002946	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
290512002947	NAD(P) binding site [chemical binding]; other site
290512002948	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
290512002949	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
290512002950	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
290512002951	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
290512002952	putative carbohydrate kinase; Provisional; Region: PRK10565
290512002953	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
290512002954	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
290512002955	putative substrate binding site [chemical binding]; other site
290512002956	putative ATP binding site [chemical binding]; other site
290512002957	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
290512002958	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
290512002959	dimerization interface [polypeptide binding]; other site
290512002960	ATP binding site [chemical binding]; other site
290512002961	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
290512002962	dimerization interface [polypeptide binding]; other site
290512002963	ATP binding site [chemical binding]; other site
290512002964	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12900
290512002965	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
290512002966	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290512002967	nucleotide binding region [chemical binding]; other site
290512002968	ATP-binding site [chemical binding]; other site
290512002969	SEC-C motif; Region: SEC-C; pfam02810
290512002970	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
290512002971	DHH family; Region: DHH; pfam01368
290512002972	DHHA1 domain; Region: DHHA1; pfam02272
290512002973	multifunctional aminopeptidase A; Provisional; Region: PRK00913
290512002974	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
290512002975	interface (dimer of trimers) [polypeptide binding]; other site
290512002976	Substrate-binding/catalytic site; other site
290512002977	Zn-binding sites [ion binding]; other site
290512002978	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
290512002979	PGAP1-like protein; Region: PGAP1; pfam07819
290512002980	Biogenesis of lysosome-related organelles complex-1 subunit 2; Region: BLOC1_2; pfam10046
290512002981	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
290512002982	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
290512002983	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
290512002984	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
290512002985	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
290512002986	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
290512002987	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
290512002988	dimer interface [polypeptide binding]; other site
290512002989	substrate binding site [chemical binding]; other site
290512002990	ATP binding site [chemical binding]; other site
290512002991	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
290512002992	thiamine phosphate binding site [chemical binding]; other site
290512002993	active site
290512002994	pyrophosphate binding site [ion binding]; other site
290512002995	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
290512002996	thiamine phosphate binding site [chemical binding]; other site
290512002997	active site
290512002998	pyrophosphate binding site [ion binding]; other site
290512002999	ribulose-1,5-biphosphate synthetase; Provisional; Region: PRK04176
290512003000	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290512003001	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
290512003002	homotrimer interaction site [polypeptide binding]; other site
290512003003	putative active site [active]
290512003004	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
290512003005	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
290512003006	C-terminal peptidase (prc); Region: prc; TIGR00225
290512003007	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
290512003008	protein binding site [polypeptide binding]; other site
290512003009	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
290512003010	Catalytic dyad [active]
290512003011	Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
290512003012	putative lipid binding site [chemical binding]; other site
290512003013	Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
290512003014	putative lipid binding site [chemical binding]; other site
290512003015	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
290512003016	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
290512003017	putative ribose interaction site [chemical binding]; other site
290512003018	putative ADP binding site [chemical binding]; other site
290512003019	signal recognition particle protein; Provisional; Region: PRK10867
290512003020	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
290512003021	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
290512003022	P loop; other site
290512003023	GTP binding site [chemical binding]; other site
290512003024	Signal peptide binding domain; Region: SRP_SPB; pfam02978
290512003025	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
290512003026	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
290512003027	RimM N-terminal domain; Region: RimM; pfam01782
290512003028	PRC-barrel domain; Region: PRC; pfam05239
290512003029	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
290512003030	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
290512003031	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
290512003032	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
290512003033	endonuclease III; Region: ENDO3c; smart00478
290512003034	minor groove reading motif; other site
290512003035	helix-hairpin-helix signature motif; other site
290512003036	substrate binding pocket [chemical binding]; other site
290512003037	active site
290512003038	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
290512003039	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
290512003040	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
290512003041	acyl-activating enzyme (AAE) consensus motif; other site
290512003042	putative AMP binding site [chemical binding]; other site
290512003043	putative active site [active]
290512003044	putative CoA binding site [chemical binding]; other site
290512003045	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
290512003046	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
290512003047	ligand binding site; other site
290512003048	tetramer interface; other site
290512003049	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
290512003050	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
290512003051	active site
290512003052	NAD binding site [chemical binding]; other site
290512003053	metal binding site [ion binding]; metal-binding site
290512003054	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
290512003055	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
290512003056	inhibitor-cofactor binding pocket; inhibition site
290512003057	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290512003058	catalytic residue [active]
290512003059	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
290512003060	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
290512003061	P-loop; other site
290512003062	Magnesium ion binding site [ion binding]; other site
290512003063	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
290512003064	Magnesium ion binding site [ion binding]; other site
290512003065	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
290512003066	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
290512003067	P-loop; other site
290512003068	Magnesium ion binding site [ion binding]; other site
290512003069	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
290512003070	Magnesium ion binding site [ion binding]; other site
290512003071	CHAD domain; Region: CHAD; pfam05235
290512003072	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
290512003073	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
290512003074	ligand binding site [chemical binding]; other site
290512003075	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
290512003076	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
290512003077	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
290512003078	putative NADP binding site [chemical binding]; other site
290512003079	putative substrate binding site [chemical binding]; other site
290512003080	active site
290512003081	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
290512003082	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
290512003083	ligand binding site [chemical binding]; other site
290512003084	flexible hinge region; other site
290512003085	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
290512003086	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
290512003087	metal binding triad; other site
290512003088	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
290512003089	active site
290512003090	catalytic site [active]
290512003091	substrate binding site [chemical binding]; other site
290512003092	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290512003093	S-adenosylmethionine binding site [chemical binding]; other site
290512003094	dihydroorotase; Validated; Region: pyrC; PRK09357
290512003095	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
290512003096	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
290512003097	active site
290512003098	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
290512003099	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
290512003100	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
290512003101	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
290512003102	polyphosphate kinase; Provisional; Region: PRK05443
290512003103	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
290512003104	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
290512003105	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
290512003106	putative domain interface [polypeptide binding]; other site
290512003107	putative active site [active]
290512003108	catalytic site [active]
290512003109	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
290512003110	putative domain interface [polypeptide binding]; other site
290512003111	putative active site [active]
290512003112	catalytic site [active]
290512003113	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
290512003114	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
290512003115	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
290512003116	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
290512003117	metal binding site [ion binding]; metal-binding site
290512003118	dimer interface [polypeptide binding]; other site
290512003119	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
290512003120	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
290512003121	intersubunit interface [polypeptide binding]; other site
290512003122	active site
290512003123	zinc binding site [ion binding]; other site
290512003124	Na+ binding site [ion binding]; other site
290512003125	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
290512003126	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
290512003127	protein binding site [polypeptide binding]; other site
290512003128	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
290512003129	Catalytic dyad [active]
290512003130	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
290512003131	argininosuccinate lyase; Provisional; Region: PRK00855
290512003132	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
290512003133	active sites [active]
290512003134	tetramer interface [polypeptide binding]; other site
290512003135	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
290512003136	classical (c) SDRs; Region: SDR_c; cd05233
290512003137	NAD(P) binding site [chemical binding]; other site
290512003138	active site
290512003139	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
290512003140	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
290512003141	Sulfate transporter family; Region: Sulfate_transp; pfam00916
290512003142	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
290512003143	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290512003144	Ligand Binding Site [chemical binding]; other site
290512003145	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290512003146	Ligand Binding Site [chemical binding]; other site
290512003147	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
290512003148	active site
290512003149	catalytic site [active]
290512003150	substrate binding site [chemical binding]; other site
290512003151	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
290512003152	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
290512003153	acyl-activating enzyme (AAE) consensus motif; other site
290512003154	putative AMP binding site [chemical binding]; other site
290512003155	putative active site [active]
290512003156	putative CoA binding site [chemical binding]; other site
290512003157	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290512003158	ATP-binding site [chemical binding]; other site
290512003159	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
290512003160	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
290512003161	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
290512003162	Family description; Region: UvrD_C_2; pfam13538
290512003163	Nuclease-related domain; Region: NERD; pfam08378
290512003164	Part of AAA domain; Region: AAA_19; pfam13245
290512003165	AAA domain; Region: AAA_22; pfam13401
290512003166	Family description; Region: UvrD_C_2; pfam13538
290512003167	Uncharacterized conserved protein [Function unknown]; Region: COG2308
290512003168	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
290512003169	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
290512003170	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
290512003171	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
290512003172	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
290512003173	6-phosphofructokinase; Provisional; Region: PRK03202
290512003174	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
290512003175	active site
290512003176	ADP/pyrophosphate binding site [chemical binding]; other site
290512003177	dimerization interface [polypeptide binding]; other site
290512003178	allosteric effector site; other site
290512003179	fructose-1,6-bisphosphate binding site; other site
290512003180	Class I aldolases; Region: Aldolase_Class_I; cl17187
290512003181	catalytic residue [active]
290512003182	argininosuccinate synthase; Provisional; Region: PRK13820
290512003183	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
290512003184	ANP binding site [chemical binding]; other site
290512003185	Substrate Binding Site II [chemical binding]; other site
290512003186	Substrate Binding Site I [chemical binding]; other site
290512003187	Arginine repressor [Transcription]; Region: ArgR; COG1438
290512003188	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
290512003189	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
290512003190	ornithine carbamoyltransferase; Provisional; Region: PRK00779
290512003191	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
290512003192	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
290512003193	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
290512003194	feedback inhibition sensing region; other site
290512003195	homohexameric interface [polypeptide binding]; other site
290512003196	nucleotide binding site [chemical binding]; other site
290512003197	N-acetyl-L-glutamate binding site [chemical binding]; other site
290512003198	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
290512003199	heterotetramer interface [polypeptide binding]; other site
290512003200	active site pocket [active]
290512003201	cleavage site
290512003202	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
290512003203	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
290512003204	PBP superfamily domain; Region: PBP_like_2; pfam12849
290512003205	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
290512003206	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
290512003207	metal binding site [ion binding]; metal-binding site
290512003208	active site
290512003209	I-site; other site
290512003210	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
290512003211	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290512003212	FtsX-like permease family; Region: FtsX; pfam02687
290512003213	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
290512003214	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290512003215	FtsX-like permease family; Region: FtsX; pfam02687
290512003216	Rubredoxin [Energy production and conversion]; Region: COG1773
290512003217	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
290512003218	iron binding site [ion binding]; other site
290512003219	putative acetyltransferase; Provisional; Region: PRK03624
290512003220	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
290512003221	Coenzyme A binding pocket [chemical binding]; other site
290512003222	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
290512003223	Predicted membrane protein [Function unknown]; Region: COG2119
290512003224	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
290512003225	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
290512003226	AAA-like domain; Region: AAA_10; pfam12846
290512003227	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
290512003228	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
290512003229	Walker A/P-loop; other site
290512003230	ATP binding site [chemical binding]; other site
290512003231	Q-loop/lid; other site
290512003232	ABC transporter signature motif; other site
290512003233	Walker B; other site
290512003234	D-loop; other site
290512003235	H-loop/switch region; other site
290512003236	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
290512003237	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
290512003238	Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045
290512003239	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
290512003240	CoA binding domain; Region: CoA_binding; smart00881
290512003241	ATP citrate (pro-S)-lyase; Region: PLN02522
290512003242	CoA-ligase; Region: Ligase_CoA; pfam00549
290512003243	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
290512003244	active site
290512003245	oxalacetate binding site [chemical binding]; other site
290512003246	citrylCoA binding site [chemical binding]; other site
290512003247	coenzyme A binding site [chemical binding]; other site
290512003248	catalytic triad [active]
290512003249	multiple promoter invertase; Provisional; Region: mpi; PRK13413
290512003250	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
290512003251	catalytic residues [active]
290512003252	catalytic nucleophile [active]
290512003253	Presynaptic Site I dimer interface [polypeptide binding]; other site
290512003254	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
290512003255	Synaptic Flat tetramer interface [polypeptide binding]; other site
290512003256	Synaptic Site I dimer interface [polypeptide binding]; other site
290512003257	DNA binding site [nucleotide binding]
290512003258	Transposase; Region: HTH_Tnp_1; cl17663
290512003259	Homeodomain-like domain; Region: HTH_32; pfam13565
290512003260	Integrase core domain; Region: rve; pfam00665
290512003261	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
290512003262	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
290512003263	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
290512003264	putative active site [active]
290512003265	putative NTP binding site [chemical binding]; other site
290512003266	putative nucleic acid binding site [nucleotide binding]; other site
290512003267	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
290512003268	Integrase core domain; Region: rve_3; pfam13683
290512003269	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
290512003270	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
290512003271	catalytic residues [active]
290512003272	catalytic nucleophile [active]
290512003273	Presynaptic Site I dimer interface [polypeptide binding]; other site
290512003274	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
290512003275	Synaptic Flat tetramer interface [polypeptide binding]; other site
290512003276	Synaptic Site I dimer interface [polypeptide binding]; other site
290512003277	DNA binding site [nucleotide binding]
290512003278	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
290512003279	TIR domain; Region: TIR_2; pfam13676
290512003280	AAA ATPase domain; Region: AAA_16; pfam13191
290512003281	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512003282	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290512003283	binding surface
290512003284	TPR motif; other site
290512003285	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290512003286	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512003287	binding surface
290512003288	TPR motif; other site
290512003289	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290512003290	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512003291	binding surface
290512003292	TPR motif; other site
290512003293	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290512003294	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512003295	binding surface
290512003296	TPR motif; other site
290512003297	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290512003298	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
290512003299	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
290512003300	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
290512003301	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
290512003302	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
290512003303	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
290512003304	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
290512003305	Walker A/P-loop; other site
290512003306	ATP binding site [chemical binding]; other site
290512003307	Q-loop/lid; other site
290512003308	ABC transporter signature motif; other site
290512003309	Walker B; other site
290512003310	D-loop; other site
290512003311	H-loop/switch region; other site
290512003312	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
290512003313	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
290512003314	Walker A/P-loop; other site
290512003315	ATP binding site [chemical binding]; other site
290512003316	Q-loop/lid; other site
290512003317	ABC transporter signature motif; other site
290512003318	Walker B; other site
290512003319	D-loop; other site
290512003320	H-loop/switch region; other site
290512003321	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
290512003322	HlyD family secretion protein; Region: HlyD_3; pfam13437
290512003323	rod shape-determining protein MreB; Provisional; Region: PRK13930
290512003324	MreB and similar proteins; Region: MreB_like; cd10225
290512003325	nucleotide binding site [chemical binding]; other site
290512003326	Mg binding site [ion binding]; other site
290512003327	putative protofilament interaction site [polypeptide binding]; other site
290512003328	RodZ interaction site [polypeptide binding]; other site
290512003329	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
290512003330	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
290512003331	dimerization interface [polypeptide binding]; other site
290512003332	putative DNA binding site [nucleotide binding]; other site
290512003333	putative Zn2+ binding site [ion binding]; other site
290512003334	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
290512003335	Predicted permeases [General function prediction only]; Region: COG0701
290512003336	Low molecular weight phosphatase family; Region: LMWPc; cd00115
290512003337	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
290512003338	active site
290512003339	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
290512003340	arsenical-resistance protein; Region: acr3; TIGR00832
290512003341	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
290512003342	SurA N-terminal domain; Region: SurA_N; pfam09312
290512003343	Cytochrome c; Region: Cytochrom_C; pfam00034
290512003344	hybrid cluster protein; Provisional; Region: PRK05290
290512003345	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
290512003346	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
290512003347	hybrid metal cluster; other site
290512003348	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512003349	TPR motif; other site
290512003350	TPR repeat; Region: TPR_11; pfam13414
290512003351	binding surface
290512003352	Predicted transcriptional regulator [Transcription]; Region: COG1959
290512003353	Transcriptional regulator; Region: Rrf2; pfam02082
290512003354	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
290512003355	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512003356	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
290512003357	FeS/SAM binding site; other site
290512003358	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
290512003359	Spore germination protein; Region: Spore_permease; cl17796
290512003360	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
290512003361	Mechanosensitive ion channel; Region: MS_channel; pfam00924
290512003362	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
290512003363	Mechanosensitive ion channel; Region: MS_channel; pfam00924
290512003364	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
290512003365	dimerization interface [polypeptide binding]; other site
290512003366	putative DNA binding site [nucleotide binding]; other site
290512003367	putative Zn2+ binding site [ion binding]; other site
290512003368	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
290512003369	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
290512003370	Walker A/P-loop; other site
290512003371	ATP binding site [chemical binding]; other site
290512003372	Q-loop/lid; other site
290512003373	ABC transporter signature motif; other site
290512003374	Walker B; other site
290512003375	D-loop; other site
290512003376	H-loop/switch region; other site
290512003377	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290512003378	FtsX-like permease family; Region: FtsX; pfam02687
290512003379	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
290512003380	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
290512003381	HlyD family secretion protein; Region: HlyD_3; pfam13437
290512003382	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
290512003383	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
290512003384	dimer interface [polypeptide binding]; other site
290512003385	Putative zinc-finger; Region: zf-HC2; pfam13490
290512003386	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
290512003387	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290512003388	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290512003389	DNA binding residues [nucleotide binding]
290512003390	lipoyl synthase; Provisional; Region: PRK05481
290512003391	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
290512003392	NADH(P)-binding; Region: NAD_binding_10; pfam13460
290512003393	NAD(P) binding site [chemical binding]; other site
290512003394	putative active site [active]
290512003395	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
290512003396	ZIP Zinc transporter; Region: Zip; pfam02535
290512003397	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
290512003398	classical (c) SDRs; Region: SDR_c; cd05233
290512003399	NAD(P) binding site [chemical binding]; other site
290512003400	active site
290512003401	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
290512003402	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
290512003403	yecA family protein; Region: ygfB_yecA; TIGR02292
290512003404	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603
290512003405	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290512003406	AAA domain; Region: AAA_23; pfam13476
290512003407	Walker A/P-loop; other site
290512003408	ATP binding site [chemical binding]; other site
290512003409	Q-loop/lid; other site
290512003410	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290512003411	ABC transporter signature motif; other site
290512003412	Walker B; other site
290512003413	D-loop; other site
290512003414	H-loop/switch region; other site
290512003415	exonuclease subunit SbcD; Provisional; Region: PRK10966
290512003416	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
290512003417	active site
290512003418	metal binding site [ion binding]; metal-binding site
290512003419	DNA binding site [nucleotide binding]
290512003420	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
290512003421	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
290512003422	Family description; Region: UvrD_C_2; pfam13538
290512003423	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
290512003424	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
290512003425	TPR repeat; Region: TPR_11; pfam13414
290512003426	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512003427	binding surface
290512003428	TPR motif; other site
290512003429	TPR repeat; Region: TPR_11; pfam13414
290512003430	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512003431	binding surface
290512003432	TPR motif; other site
290512003433	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
290512003434	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512003435	FeS/SAM binding site; other site
290512003436	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
290512003437	8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588
290512003438	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
290512003439	minor groove reading motif; other site
290512003440	helix-hairpin-helix signature motif; other site
290512003441	substrate binding pocket [chemical binding]; other site
290512003442	active site
290512003443	Transcriptional regulators [Transcription]; Region: MarR; COG1846
290512003444	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
290512003445	putative DNA binding site [nucleotide binding]; other site
290512003446	dimerization interface [polypeptide binding]; other site
290512003447	putative Zn2+ binding site [ion binding]; other site
290512003448	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14456
290512003449	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512003450	FeS/SAM binding site; other site
290512003451	adenylate kinase; Reviewed; Region: adk; PRK00279
290512003452	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
290512003453	AMP-binding site [chemical binding]; other site
290512003454	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
290512003455	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290512003456	primosomal protein N' Region: priA; TIGR00595
290512003457	ATP binding site [chemical binding]; other site
290512003458	putative Mg++ binding site [ion binding]; other site
290512003459	FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; cl17764
290512003460	Zn binding sites [ion binding]; other site
290512003461	phosphatidylinositol 3-phosphate binding site [chemical binding]; other site
290512003462	helicase superfamily c-terminal domain; Region: HELICc; smart00490
290512003463	ATP-binding site [chemical binding]; other site
290512003464	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
290512003465	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
290512003466	Dehydroquinase class II; Region: DHquinase_II; pfam01220
290512003467	trimer interface [polypeptide binding]; other site
290512003468	active site
290512003469	dimer interface [polypeptide binding]; other site
290512003470	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
290512003471	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
290512003472	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
290512003473	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290512003474	Walker A motif; other site
290512003475	ATP binding site [chemical binding]; other site
290512003476	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
290512003477	Walker B motif; other site
290512003478	arginine finger; other site
290512003479	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
290512003480	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
290512003481	active site
290512003482	HslU subunit interaction site [polypeptide binding]; other site
290512003483	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
290512003484	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
290512003485	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
290512003486	Protein of unknown function (DUF3109); Region: DUF3109; pfam11307
290512003487	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14174
290512003488	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
290512003489	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
290512003490	homodimer interface [polypeptide binding]; other site
290512003491	NADP binding site [chemical binding]; other site
290512003492	substrate binding site [chemical binding]; other site
290512003493	DNA repair protein RadA; Provisional; Region: PRK11823
290512003494	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
290512003495	Walker A motif/ATP binding site; other site
290512003496	ATP binding site [chemical binding]; other site
290512003497	Walker B motif; other site
290512003498	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
290512003499	Membrane protein of unknown function; Region: DUF360; pfam04020
290512003500	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
290512003501	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
290512003502	putative NAD(P) binding site [chemical binding]; other site
290512003503	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
290512003504	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290512003505	Walker A/P-loop; other site
290512003506	ATP binding site [chemical binding]; other site
290512003507	Q-loop/lid; other site
290512003508	ABC transporter signature motif; other site
290512003509	Walker B; other site
290512003510	D-loop; other site
290512003511	H-loop/switch region; other site
290512003512	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
290512003513	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
290512003514	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
290512003515	TM-ABC transporter signature motif; other site
290512003516	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
290512003517	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
290512003518	Cl- selectivity filter; other site
290512003519	Cl- binding residues [ion binding]; other site
290512003520	pore gating glutamate residue; other site
290512003521	dimer interface [polypeptide binding]; other site
290512003522	FOG: CBS domain [General function prediction only]; Region: COG0517
290512003523	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
290512003524	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
290512003525	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
290512003526	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
290512003527	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
290512003528	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
290512003529	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
290512003530	substrate binding pocket [chemical binding]; other site
290512003531	chain length determination region; other site
290512003532	substrate-Mg2+ binding site; other site
290512003533	catalytic residues [active]
290512003534	aspartate-rich region 1; other site
290512003535	active site lid residues [active]
290512003536	aspartate-rich region 2; other site
290512003537	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
290512003538	S-formylglutathione hydrolase; Region: PLN02442
290512003539	dephospho-CoA kinase; Provisional; Region: coaE; PRK14731
290512003540	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
290512003541	CoA-binding site [chemical binding]; other site
290512003542	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
290512003543	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
290512003544	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
290512003545	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
290512003546	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
290512003547	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
290512003548	putative RNA binding site [nucleotide binding]; other site
290512003549	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290512003550	S-adenosylmethionine binding site [chemical binding]; other site
290512003551	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
290512003552	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
290512003553	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
290512003554	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
290512003555	catalytic residues [active]
290512003556	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
290512003557	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
290512003558	Walker A/P-loop; other site
290512003559	ATP binding site [chemical binding]; other site
290512003560	Q-loop/lid; other site
290512003561	ABC transporter signature motif; other site
290512003562	Walker B; other site
290512003563	D-loop; other site
290512003564	H-loop/switch region; other site
290512003565	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
290512003566	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
290512003567	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
290512003568	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
290512003569	Protein of unknown function (DUF1318); Region: DUF1318; pfam07027
290512003570	Dicarboxylate transport; Region: DctA-YdbH; cl14674
290512003571	Dicarboxylate transport; Region: DctA-YdbH; cl14674
290512003572	Dicarboxylate transport; Region: DctA-YdbH; pfam11739
290512003573	flavoprotein, HI0933 family; Region: TIGR00275
290512003574	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290512003575	HlyD family secretion protein; Region: HlyD_3; pfam13437
290512003576	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290512003577	FtsX-like permease family; Region: FtsX; pfam02687
290512003578	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
290512003579	FtsX-like permease family; Region: FtsX; pfam02687
290512003580	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
290512003581	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
290512003582	Walker A/P-loop; other site
290512003583	ATP binding site [chemical binding]; other site
290512003584	Q-loop/lid; other site
290512003585	ABC transporter signature motif; other site
290512003586	Walker B; other site
290512003587	D-loop; other site
290512003588	H-loop/switch region; other site
290512003589	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
290512003590	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
290512003591	putative active site [active]
290512003592	heme pocket [chemical binding]; other site
290512003593	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290512003594	putative active site [active]
290512003595	heme pocket [chemical binding]; other site
290512003596	PAS domain S-box; Region: sensory_box; TIGR00229
290512003597	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290512003598	putative active site [active]
290512003599	heme pocket [chemical binding]; other site
290512003600	PAS fold; Region: PAS_4; pfam08448
290512003601	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290512003602	putative active site [active]
290512003603	heme pocket [chemical binding]; other site
290512003604	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290512003605	dimer interface [polypeptide binding]; other site
290512003606	phosphorylation site [posttranslational modification]
290512003607	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290512003608	ATP binding site [chemical binding]; other site
290512003609	Mg2+ binding site [ion binding]; other site
290512003610	G-X-G motif; other site
290512003611	Response regulator receiver domain; Region: Response_reg; pfam00072
290512003612	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290512003613	active site
290512003614	phosphorylation site [posttranslational modification]
290512003615	intermolecular recognition site; other site
290512003616	dimerization interface [polypeptide binding]; other site
290512003617	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
290512003618	DNA photolyase; Region: DNA_photolyase; pfam00875
290512003619	Uncharacterized conserved protein [Function unknown]; Region: COG1434
290512003620	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
290512003621	putative active site [active]
290512003622	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
290512003623	NADH(P)-binding; Region: NAD_binding_10; pfam13460
290512003624	NAD(P) binding site [chemical binding]; other site
290512003625	putative active site [active]
290512003626	Protein of unknown function (DUF1847); Region: DUF1847; pfam08901
290512003627	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
290512003628	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
290512003629	metal binding site [ion binding]; metal-binding site
290512003630	dimer interface [polypeptide binding]; other site
290512003631	N-acetyltransferase; Region: Acetyltransf_2; cl00949
290512003632	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
290512003633	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290512003634	active site
290512003635	phosphorylation site [posttranslational modification]
290512003636	intermolecular recognition site; other site
290512003637	dimerization interface [polypeptide binding]; other site
290512003638	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
290512003639	DNA binding site [nucleotide binding]
290512003640	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290512003641	active site
290512003642	motif I; other site
290512003643	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
290512003644	motif II; other site
290512003645	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
290512003646	NADH(P)-binding; Region: NAD_binding_10; pfam13460
290512003647	NAD(P) binding site [chemical binding]; other site
290512003648	putative active site [active]
290512003649	von Willebrand factor type A domain; Region: VWA_2; pfam13519
290512003650	metal ion-dependent adhesion site (MIDAS); other site
290512003651	L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196
290512003652	Domain of unknown function (DUF4403); Region: DUF4403; pfam14356
290512003653	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
290512003654	mercuric reductase; Validated; Region: PRK06370
290512003655	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
290512003656	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
290512003657	SET domain; Region: SET; pfam00856
290512003658	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
290512003659	dinuclear metal binding motif [ion binding]; other site
290512003660	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
290512003661	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183
290512003662	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
290512003663	putative active site [active]
290512003664	metal binding site [ion binding]; metal-binding site
290512003665	KWG Leptospira; Region: KWG; pfam07656
290512003666	KWG Leptospira; Region: KWG; pfam07656
290512003667	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
290512003668	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
290512003669	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
290512003670	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323
290512003671	gating phenylalanine in ion channel; other site
290512003672	OsmC-like protein; Region: OsmC; pfam02566
290512003673	cobalamin synthase; Reviewed; Region: cobS; PRK00235
290512003674	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
290512003675	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
290512003676	catalytic site [active]
290512003677	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
290512003678	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
290512003679	putative dimer interface [polypeptide binding]; other site
290512003680	active site pocket [active]
290512003681	putative cataytic base [active]
290512003682	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
290512003683	homotrimer interface [polypeptide binding]; other site
290512003684	Walker A motif; other site
290512003685	GTP binding site [chemical binding]; other site
290512003686	Walker B motif; other site
290512003687	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
290512003688	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
290512003689	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
290512003690	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
290512003691	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
290512003692	NADP binding site [chemical binding]; other site
290512003693	dimer interface [polypeptide binding]; other site
290512003694	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
290512003695	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
290512003696	Walker A/P-loop; other site
290512003697	ATP binding site [chemical binding]; other site
290512003698	Q-loop/lid; other site
290512003699	ABC transporter signature motif; other site
290512003700	Walker B; other site
290512003701	D-loop; other site
290512003702	H-loop/switch region; other site
290512003703	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
290512003704	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
290512003705	ABC-ATPase subunit  interface; other site
290512003706	dimer interface [polypeptide binding]; other site
290512003707	putative PBP binding regions; other site
290512003708	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
290512003709	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
290512003710	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290512003711	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290512003712	homodimer interface [polypeptide binding]; other site
290512003713	catalytic residue [active]
290512003714	cobyric acid synthase; Provisional; Region: PRK00784
290512003715	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
290512003716	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
290512003717	catalytic triad [active]
290512003718	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
290512003719	putative FMN binding site [chemical binding]; other site
290512003720	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
290512003721	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
290512003722	N-terminal plug; other site
290512003723	ligand-binding site [chemical binding]; other site
290512003724	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
290512003725	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
290512003726	THF binding site; other site
290512003727	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
290512003728	substrate binding site [chemical binding]; other site
290512003729	THF binding site; other site
290512003730	zinc-binding site [ion binding]; other site
290512003731	Cna protein B-type domain; Region: Cna_B_2; pfam13715
290512003732	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
290512003733	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
290512003734	N-terminal plug; other site
290512003735	ligand-binding site [chemical binding]; other site
290512003736	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
290512003737	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
290512003738	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
290512003739	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
290512003740	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
290512003741	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
290512003742	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290512003743	Walker A motif; other site
290512003744	ATP binding site [chemical binding]; other site
290512003745	Walker B motif; other site
290512003746	arginine finger; other site
290512003747	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
290512003748	metal ion-dependent adhesion site (MIDAS); other site
290512003749	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
290512003750	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
290512003751	N-terminal plug; other site
290512003752	ligand-binding site [chemical binding]; other site
290512003753	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
290512003754	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
290512003755	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
290512003756	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
290512003757	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512003758	FeS/SAM binding site; other site
290512003759	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
290512003760	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
290512003761	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
290512003762	Metal-binding active site; metal-binding site
290512003763	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
290512003764	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
290512003765	N-terminal plug; other site
290512003766	ligand-binding site [chemical binding]; other site
290512003767	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
290512003768	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
290512003769	ABC-ATPase subunit  interface; other site
290512003770	dimer interface [polypeptide binding]; other site
290512003771	putative PBP binding regions; other site
290512003772	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
290512003773	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
290512003774	Walker A/P-loop; other site
290512003775	ATP binding site [chemical binding]; other site
290512003776	Q-loop/lid; other site
290512003777	ABC transporter signature motif; other site
290512003778	Walker B; other site
290512003779	D-loop; other site
290512003780	H-loop/switch region; other site
290512003781	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
290512003782	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
290512003783	intersubunit interface [polypeptide binding]; other site
290512003784	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
290512003785	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
290512003786	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
290512003787	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
290512003788	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
290512003789	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
290512003790	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
290512003791	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
290512003792	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
290512003793	active site
290512003794	SAM binding site [chemical binding]; other site
290512003795	homodimer interface [polypeptide binding]; other site
290512003796	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
290512003797	active site
290512003798	putative homodimer interface [polypeptide binding]; other site
290512003799	SAM binding site [chemical binding]; other site
290512003800	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290512003801	S-adenosylmethionine binding site [chemical binding]; other site
290512003802	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
290512003803	active site
290512003804	SAM binding site [chemical binding]; other site
290512003805	homodimer interface [polypeptide binding]; other site
290512003806	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
290512003807	Precorrin-8X methylmutase; Region: CbiC; pfam02570
290512003808	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
290512003809	active site
290512003810	SAM binding site [chemical binding]; other site
290512003811	homodimer interface [polypeptide binding]; other site
290512003812	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
290512003813	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
290512003814	active site
290512003815	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
290512003816	active site
290512003817	N-terminal domain interface [polypeptide binding]; other site
290512003818	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
290512003819	active site
290512003820	SAM binding site [chemical binding]; other site
290512003821	homodimer interface [polypeptide binding]; other site
290512003822	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
290512003823	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
290512003824	active site
290512003825	catalytic triad [active]
290512003826	dimer interface [polypeptide binding]; other site
290512003827	Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955
290512003828	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
290512003829	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
290512003830	intersubunit interface [polypeptide binding]; other site
290512003831	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
290512003832	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
290512003833	Walker A/P-loop; other site
290512003834	ATP binding site [chemical binding]; other site
290512003835	Q-loop/lid; other site
290512003836	ABC transporter signature motif; other site
290512003837	Walker B; other site
290512003838	D-loop; other site
290512003839	H-loop/switch region; other site
290512003840	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
290512003841	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
290512003842	ABC-ATPase subunit  interface; other site
290512003843	dimer interface [polypeptide binding]; other site
290512003844	putative PBP binding regions; other site
290512003845	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
290512003846	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
290512003847	putative ligand binding site [chemical binding]; other site
290512003848	Ferredoxin [Energy production and conversion]; Region: COG1146
290512003849	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
290512003850	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
290512003851	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
290512003852	N-terminal plug; other site
290512003853	ligand-binding site [chemical binding]; other site
290512003854	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
290512003855	putative hydrophobic ligand binding site [chemical binding]; other site
290512003856	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
290512003857	nudix motif; other site
290512003858	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
290512003859	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
290512003860	cobalamin binding residues [chemical binding]; other site
290512003861	putative BtuC binding residues; other site
290512003862	dimer interface [polypeptide binding]; other site
290512003863	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290512003864	Major Facilitator Superfamily; Region: MFS_1; pfam07690
290512003865	putative substrate translocation pore; other site
290512003866	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
290512003867	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
290512003868	active site
290512003869	NTP binding site [chemical binding]; other site
290512003870	metal binding triad [ion binding]; metal-binding site
290512003871	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
290512003872	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
290512003873	Zn2+ binding site [ion binding]; other site
290512003874	Mg2+ binding site [ion binding]; other site
290512003875	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
290512003876	adenylosuccinate lyase; Provisional; Region: PRK07492
290512003877	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
290512003878	tetramer interface [polypeptide binding]; other site
290512003879	active site
290512003880	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
290512003881	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
290512003882	ferredoxin; Validated; Region: PRK07118
290512003883	Putative Fe-S cluster; Region: FeS; cl17515
290512003884	4Fe-4S binding domain; Region: Fer4; pfam00037
290512003885	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
290512003886	SLBB domain; Region: SLBB; pfam10531
290512003887	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
290512003888	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
290512003889	FMN-binding domain; Region: FMN_bind; cl01081
290512003890	electron transport complex RsxE subunit; Provisional; Region: PRK12405
290512003891	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
290512003892	amino acid transporter; Region: 2A0306; TIGR00909
290512003893	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
290512003894	Transposase; Region: DEDD_Tnp_IS110; pfam01548
290512003895	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
290512003896	Transposase IS200 like; Region: Y1_Tnp; cl00848
290512003897	zinc transporter ZupT; Provisional; Region: PRK04201
290512003898	ZIP Zinc transporter; Region: Zip; pfam02535
290512003899	Uncharacterized conserved protein [Function unknown]; Region: COG1262
290512003900	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
290512003901	Ycf46; Provisional; Region: ycf46; CHL00195
290512003902	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290512003903	Walker A motif; other site
290512003904	ATP binding site [chemical binding]; other site
290512003905	Walker B motif; other site
290512003906	arginine finger; other site
290512003907	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
290512003908	nucleotide binding site [chemical binding]; other site
290512003909	putative NEF/HSP70 interaction site [polypeptide binding]; other site
290512003910	SBD interface [polypeptide binding]; other site
290512003911	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
290512003912	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
290512003913	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
290512003914	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
290512003915	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
290512003916	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
290512003917	Transposase; Region: HTH_Tnp_1; cl17663
290512003918	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
290512003919	TIR domain; Region: TIR_2; pfam13676
290512003920	6-phosphofructokinase; Region: PLN02884
290512003921	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
290512003922	active site
290512003923	ADP/pyrophosphate binding site [chemical binding]; other site
290512003924	allosteric effector site; other site
290512003925	dimerization interface [polypeptide binding]; other site
290512003926	fructose-1,6-bisphosphate binding site; other site
290512003927	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
290512003928	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
290512003929	ApbE family; Region: ApbE; pfam02424
290512003930	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
290512003931	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
290512003932	active site
290512003933	dimer interface [polypeptide binding]; other site
290512003934	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
290512003935	dimer interface [polypeptide binding]; other site
290512003936	active site
290512003937	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
290512003938	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
290512003939	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
290512003940	Nitrogen regulatory protein P-II; Region: P-II; smart00938
290512003941	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
290512003942	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
290512003943	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
290512003944	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
290512003945	cobalt transport protein CbiM; Validated; Region: PRK06265
290512003946	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
290512003947	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
290512003948	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
290512003949	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
290512003950	Walker A/P-loop; other site
290512003951	ATP binding site [chemical binding]; other site
290512003952	Q-loop/lid; other site
290512003953	ABC transporter signature motif; other site
290512003954	Walker B; other site
290512003955	D-loop; other site
290512003956	H-loop/switch region; other site
290512003957	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
290512003958	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
290512003959	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
290512003960	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
290512003961	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
290512003962	P loop; other site
290512003963	Nucleotide binding site [chemical binding]; other site
290512003964	DTAP/Switch II; other site
290512003965	Switch I; other site
290512003966	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
290512003967	N-acetyl-D-glucosamine binding site [chemical binding]; other site
290512003968	catalytic residue [active]
290512003969	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
290512003970	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
290512003971	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
290512003972	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
290512003973	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
290512003974	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
290512003975	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
290512003976	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
290512003977	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
290512003978	dimerization interface 3.5A [polypeptide binding]; other site
290512003979	active site
290512003980	Alpha amylase catalytic domain found in maltosyltransferase; Region: AmyAc_MTase_N; cd11335
290512003981	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
290512003982	homodimer interface [polypeptide binding]; other site
290512003983	active site
290512003984	catalytic site [active]
290512003985	maltose binding site 2 [chemical binding]; other site
290512003986	Ribokinase-like subgroup C.  Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946
290512003987	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
290512003988	substrate binding site [chemical binding]; other site
290512003989	ATP binding site [chemical binding]; other site
290512003990	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
290512003991	Na binding site [ion binding]; other site
290512003992	Maf-like protein; Region: Maf; pfam02545
290512003993	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
290512003994	active site
290512003995	dimer interface [polypeptide binding]; other site
290512003996	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
290512003997	anti sigma factor interaction site; other site
290512003998	regulatory phosphorylation site [posttranslational modification]; other site
290512003999	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
290512004000	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
290512004001	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
290512004002	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290512004003	S-adenosylmethionine binding site [chemical binding]; other site
290512004004	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
290512004005	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
290512004006	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
290512004007	Coenzyme A binding pocket [chemical binding]; other site
290512004008	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
290512004009	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
290512004010	active site
290512004011	HIGH motif; other site
290512004012	KMSKS motif; other site
290512004013	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
290512004014	tRNA binding surface [nucleotide binding]; other site
290512004015	anticodon binding site; other site
290512004016	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
290512004017	dimer interface [polypeptide binding]; other site
290512004018	putative tRNA-binding site [nucleotide binding]; other site
290512004019	PSP1 C-terminal conserved region; Region: PSP1; pfam04468
290512004020	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
290512004021	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551
290512004022	putative acyl-acceptor binding pocket; other site
290512004023	aspartate aminotransferase; Provisional; Region: PRK05764
290512004024	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290512004025	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290512004026	homodimer interface [polypeptide binding]; other site
290512004027	catalytic residue [active]
290512004028	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
290512004029	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
290512004030	active site
290512004031	(T/H)XGH motif; other site
290512004032	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
290512004033	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290512004034	S-adenosylmethionine binding site [chemical binding]; other site
290512004035	transketolase; Reviewed; Region: PRK05899
290512004036	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
290512004037	TPP-binding site [chemical binding]; other site
290512004038	dimer interface [polypeptide binding]; other site
290512004039	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
290512004040	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
290512004041	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
290512004042	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
290512004043	ATP binding site [chemical binding]; other site
290512004044	active site
290512004045	substrate binding site [chemical binding]; other site
290512004046	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
290512004047	putative catalytic site [active]
290512004048	putative metal binding site [ion binding]; other site
290512004049	putative phosphate binding site [ion binding]; other site
290512004050	vacuolar-type H(+)-translocating pyrophosphatase; Region: V_PPase; TIGR01104
290512004051	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
290512004052	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
290512004053	putative active site [active]
290512004054	catalytic residue [active]
290512004055	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
290512004056	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
290512004057	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
290512004058	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
290512004059	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290512004060	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290512004061	homodimer interface [polypeptide binding]; other site
290512004062	catalytic residue [active]
290512004063	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
290512004064	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
290512004065	DNA binding residues [nucleotide binding]
290512004066	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
290512004067	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
290512004068	NADP binding site [chemical binding]; other site
290512004069	homopentamer interface [polypeptide binding]; other site
290512004070	substrate binding site [chemical binding]; other site
290512004071	active site
290512004072	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
290512004073	PhoH-like protein; Region: PhoH; pfam02562
290512004074	Transposase IS200 like; Region: Y1_Tnp; cl00848
290512004075	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
290512004076	Domain of unknown function (DUF3127); Region: DUF3127; pfam11325
290512004077	benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224
290512004078	benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224
290512004079	bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566
290512004080	UbiA prenyltransferase family; Region: UbiA; pfam01040
290512004081	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
290512004082	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
290512004083	active site
290512004084	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
290512004085	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
290512004086	Low molecular weight phosphatase family; Region: LMWPc; cd00115
290512004087	active site
290512004088	bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550
290512004089	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
290512004090	methionine sulfoxide reductase A; Provisional; Region: PRK14054
290512004091	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
290512004092	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
290512004093	catalytic residues [active]
290512004094	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
290512004095	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
290512004096	putative hydrophobic ligand binding site [chemical binding]; other site
290512004097	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
290512004098	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
290512004099	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290512004100	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
290512004101	HlyD family secretion protein; Region: HlyD_3; pfam13437
290512004102	Helix-turn-helix domain; Region: HTH_18; pfam12833
290512004103	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
290512004104	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
290512004105	Outer membrane efflux protein; Region: OEP; pfam02321
290512004106	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
290512004107	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
290512004108	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290512004109	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
290512004110	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
290512004111	Ferrochelatase; Region: Ferrochelatase; pfam00762
290512004112	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
290512004113	C-terminal domain interface [polypeptide binding]; other site
290512004114	active site
290512004115	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
290512004116	active site
290512004117	N-terminal domain interface [polypeptide binding]; other site
290512004118	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
290512004119	Transposase; Region: DEDD_Tnp_IS110; pfam01548
290512004120	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
290512004121	Methyltransferase domain; Region: Methyltransf_31; pfam13847
290512004122	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290512004123	S-adenosylmethionine binding site [chemical binding]; other site
290512004124	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648
290512004125	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
290512004126	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
290512004127	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693
290512004128	CT1975-like protein; Region: Cas_CT1975; pfam09344
290512004129	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
290512004130	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731
290512004131	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729
290512004132	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
290512004133	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
290512004134	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
290512004135	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
290512004136	active site
290512004137	catalytic site [active]
290512004138	substrate binding site [chemical binding]; other site
290512004139	Predicted transcriptional regulator [Transcription]; Region: COG2378
290512004140	WYL domain; Region: WYL; pfam13280
290512004141	B12 binding domain; Region: B12-binding; pfam02310
290512004142	B12 binding site [chemical binding]; other site
290512004143	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
290512004144	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512004145	FeS/SAM binding site; other site
290512004146	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
290512004147	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
290512004148	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290512004149	active site
290512004150	phosphorylation site [posttranslational modification]
290512004151	intermolecular recognition site; other site
290512004152	dimerization interface [polypeptide binding]; other site
290512004153	Response regulator receiver domain; Region: Response_reg; pfam00072
290512004154	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290512004155	active site
290512004156	phosphorylation site [posttranslational modification]
290512004157	intermolecular recognition site; other site
290512004158	dimerization interface [polypeptide binding]; other site
290512004159	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290512004160	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
290512004161	putative active site [active]
290512004162	heme pocket [chemical binding]; other site
290512004163	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290512004164	putative active site [active]
290512004165	heme pocket [chemical binding]; other site
290512004166	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
290512004167	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290512004168	putative active site [active]
290512004169	heme pocket [chemical binding]; other site
290512004170	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290512004171	dimer interface [polypeptide binding]; other site
290512004172	phosphorylation site [posttranslational modification]
290512004173	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290512004174	ATP binding site [chemical binding]; other site
290512004175	Mg2+ binding site [ion binding]; other site
290512004176	G-X-G motif; other site
290512004177	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
290512004178	active site
290512004179	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
290512004180	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
290512004181	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
290512004182	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
290512004183	active site
290512004184	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
290512004185	magnesium chelatase, H subunit; Region: BchH; TIGR02025
290512004186	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
290512004187	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
290512004188	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
290512004189	magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031
290512004190	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
290512004191	metal ion-dependent adhesion site (MIDAS); other site
290512004192	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
290512004193	AAA ATPase domain; Region: AAA_16; pfam13191
290512004194	Walker A motif; other site
290512004195	ATP binding site [chemical binding]; other site
290512004196	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
290512004197	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
290512004198	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
290512004199	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
290512004200	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
290512004201	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
290512004202	RNA binding surface [nucleotide binding]; other site
290512004203	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
290512004204	active site
290512004205	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
290512004206	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
290512004207	YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779
290512004208	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
290512004209	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
290512004210	radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334
290512004211	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512004212	FeS/SAM binding site; other site
290512004213	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
290512004214	nif11-like leader peptide domain; Region: ocin_TIGR03798
290512004215	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
290512004216	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290512004217	Walker A/P-loop; other site
290512004218	ATP binding site [chemical binding]; other site
290512004219	Q-loop/lid; other site
290512004220	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
290512004221	ABC transporter signature motif; other site
290512004222	Walker B; other site
290512004223	D-loop; other site
290512004224	ABC transporter; Region: ABC_tran_2; pfam12848
290512004225	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
290512004226	ABC transporter; Region: ABC_tran_2; pfam12848
290512004227	Transposase IS200 like; Region: Y1_Tnp; cl00848
290512004228	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
290512004229	NACHT domain; Region: NACHT; pfam05729
290512004230	Uncharacterized conserved protein [Function unknown]; Region: COG1262
290512004231	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
290512004232	Transposase IS200 like; Region: Y1_Tnp; cl00848
290512004233	2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11869
290512004234	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
290512004235	TPP-binding site [chemical binding]; other site
290512004236	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
290512004237	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
290512004238	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
290512004239	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
290512004240	dimer interface [polypeptide binding]; other site
290512004241	PYR/PP interface [polypeptide binding]; other site
290512004242	TPP binding site [chemical binding]; other site
290512004243	substrate binding site [chemical binding]; other site
290512004244	Staphylococcal nuclease homologues; Region: SNc; smart00318
290512004245	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
290512004246	Catalytic site; other site
290512004247	glutamate dehydrogenase; Provisional; Region: PRK09414
290512004248	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
290512004249	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
290512004250	NAD(P) binding site [chemical binding]; other site
290512004251	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
290512004252	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290512004253	NAD(P) binding site [chemical binding]; other site
290512004254	active site
290512004255	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
290512004256	thymidylate kinase; Validated; Region: tmk; PRK00698
290512004257	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
290512004258	TMP-binding site; other site
290512004259	ATP-binding site [chemical binding]; other site
290512004260	phosphoglycolate phosphatase; Provisional; Region: PRK01158
290512004261	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
290512004262	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290512004263	motif II; other site
290512004264	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
290512004265	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
290512004266	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
290512004267	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
290512004268	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
290512004269	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
290512004270	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
290512004271	substrate binding site; other site
290512004272	dimer interface; other site
290512004273	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
290512004274	CoenzymeA binding site [chemical binding]; other site
290512004275	subunit interaction site [polypeptide binding]; other site
290512004276	PHB binding site; other site
290512004277	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
290512004278	B12 binding site [chemical binding]; other site
290512004279	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
290512004280	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512004281	FeS/SAM binding site; other site
290512004282	HipA N-terminal domain; Region: Couple_hipA; pfam13657
290512004283	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
290512004284	HipA-like N-terminal domain; Region: HipA_N; pfam07805
290512004285	HipA-like C-terminal domain; Region: HipA_C; pfam07804
290512004286	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290512004287	non-specific DNA binding site [nucleotide binding]; other site
290512004288	salt bridge; other site
290512004289	sequence-specific DNA binding site [nucleotide binding]; other site
290512004290	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
290512004291	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
290512004292	dimer interface [polypeptide binding]; other site
290512004293	anticodon binding site; other site
290512004294	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
290512004295	homodimer interface [polypeptide binding]; other site
290512004296	motif 1; other site
290512004297	active site
290512004298	motif 2; other site
290512004299	GAD domain; Region: GAD; pfam02938
290512004300	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
290512004301	active site
290512004302	motif 3; other site
290512004303	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954
290512004304	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290512004305	Walker A motif; other site
290512004306	ATP binding site [chemical binding]; other site
290512004307	Walker B motif; other site
290512004308	arginine finger; other site
290512004309	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
290512004310	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
290512004311	ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214
290512004312	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
290512004313	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
290512004314	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
290512004315	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
290512004316	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
290512004317	putative active site [active]
290512004318	catalytic triad [active]
290512004319	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
290512004320	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
290512004321	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
290512004322	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
290512004323	oligomerization interface [polypeptide binding]; other site
290512004324	active site
290512004325	metal binding site [ion binding]; metal-binding site
290512004326	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
290512004327	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
290512004328	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
290512004329	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
290512004330	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
290512004331	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
290512004332	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
290512004333	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290512004334	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
290512004335	HlyD family secretion protein; Region: HlyD_3; pfam13437
290512004336	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
290512004337	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
290512004338	Walker A/P-loop; other site
290512004339	ATP binding site [chemical binding]; other site
290512004340	Q-loop/lid; other site
290512004341	ABC transporter signature motif; other site
290512004342	Walker B; other site
290512004343	D-loop; other site
290512004344	H-loop/switch region; other site
290512004345	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290512004346	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
290512004347	FtsX-like permease family; Region: FtsX; pfam02687
290512004348	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290512004349	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
290512004350	FtsX-like permease family; Region: FtsX; pfam02687
290512004351	Predicted membrane protein [Function unknown]; Region: COG3431
290512004352	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
290512004353	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
290512004354	ligand binding site [chemical binding]; other site
290512004355	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
290512004356	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
290512004357	Protein of unknown function, DUF547; Region: DUF547; pfam04784
290512004358	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
290512004359	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
290512004360	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
290512004361	trimer interface [polypeptide binding]; other site
290512004362	active site
290512004363	UDP-GlcNAc binding site [chemical binding]; other site
290512004364	lipid binding site [chemical binding]; lipid-binding site
290512004365	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
290512004366	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
290512004367	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
290512004368	active site
290512004369	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
290512004370	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
290512004371	5S rRNA interface [nucleotide binding]; other site
290512004372	CTC domain interface [polypeptide binding]; other site
290512004373	L16 interface [polypeptide binding]; other site
290512004374	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
290512004375	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
290512004376	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290512004377	dimer interface [polypeptide binding]; other site
290512004378	conserved gate region; other site
290512004379	putative PBP binding loops; other site
290512004380	ABC-ATPase subunit interface; other site
290512004381	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
290512004382	dimer interface [polypeptide binding]; other site
290512004383	ADP-ribose binding site [chemical binding]; other site
290512004384	active site
290512004385	nudix motif; other site
290512004386	metal binding site [ion binding]; metal-binding site
290512004387	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
290512004388	Competence protein; Region: Competence; pfam03772
290512004389	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
290512004390	FAD binding site [chemical binding]; other site
290512004391	diaminopimelate decarboxylase; Region: lysA; TIGR01048
290512004392	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
290512004393	active site
290512004394	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
290512004395	substrate binding site [chemical binding]; other site
290512004396	catalytic residues [active]
290512004397	dimer interface [polypeptide binding]; other site
290512004398	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
290512004399	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
290512004400	Putative zinc ribbon domain; Region: DUF164; pfam02591
290512004401	hypothetical protein; Provisional; Region: PRK08912
290512004402	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290512004403	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290512004404	homodimer interface [polypeptide binding]; other site
290512004405	catalytic residue [active]
290512004406	Protein of unknown function (DUF456); Region: DUF456; pfam04306
290512004407	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
290512004408	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
290512004409	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
290512004410	HflX GTPase family; Region: HflX; cd01878
290512004411	G1 box; other site
290512004412	GTP/Mg2+ binding site [chemical binding]; other site
290512004413	Switch I region; other site
290512004414	G2 box; other site
290512004415	G3 box; other site
290512004416	Switch II region; other site
290512004417	G4 box; other site
290512004418	G5 box; other site
290512004419	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
290512004420	active site lid residues [active]
290512004421	substrate binding pocket [chemical binding]; other site
290512004422	catalytic residues [active]
290512004423	substrate-Mg2+ binding site; other site
290512004424	aspartate-rich region 1; other site
290512004425	aspartate-rich region 2; other site
290512004426	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
290512004427	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
290512004428	dimer interface [polypeptide binding]; other site
290512004429	putative anticodon binding site; other site
290512004430	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
290512004431	motif 1; other site
290512004432	active site
290512004433	motif 2; other site
290512004434	motif 3; other site
290512004435	Divergent AAA domain; Region: AAA_4; pfam04326
290512004436	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
290512004437	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
290512004438	putative NAD(P) binding site [chemical binding]; other site
290512004439	active site
290512004440	putative substrate binding site [chemical binding]; other site
290512004441	transcriptional activator RfaH; Region: RfaH; TIGR01955
290512004442	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), TaA; Region: NGN_SP_TaA; cd09893
290512004443	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
290512004444	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
290512004445	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
290512004446	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
290512004447	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512004448	FeS/SAM binding site; other site
290512004449	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
290512004450	glycerol kinase; Provisional; Region: glpK; PRK00047
290512004451	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
290512004452	N- and C-terminal domain interface [polypeptide binding]; other site
290512004453	active site
290512004454	MgATP binding site [chemical binding]; other site
290512004455	catalytic site [active]
290512004456	metal binding site [ion binding]; metal-binding site
290512004457	glycerol binding site [chemical binding]; other site
290512004458	homotetramer interface [polypeptide binding]; other site
290512004459	homodimer interface [polypeptide binding]; other site
290512004460	FBP binding site [chemical binding]; other site
290512004461	protein IIAGlc interface [polypeptide binding]; other site
290512004462	shikimate kinase; Reviewed; Region: aroK; PRK00131
290512004463	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
290512004464	ADP binding site [chemical binding]; other site
290512004465	magnesium binding site [ion binding]; other site
290512004466	putative shikimate binding site; other site
290512004467	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
290512004468	active site
290512004469	dimer interface [polypeptide binding]; other site
290512004470	metal binding site [ion binding]; metal-binding site
290512004471	pantothenate kinase; Reviewed; Region: PRK13320
290512004472	Uncharacterized conserved protein [Function unknown]; Region: COG0432
290512004473	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
290512004474	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
290512004475	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
290512004476	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
290512004477	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
290512004478	dimerization interface [polypeptide binding]; other site
290512004479	putative DNA binding site [nucleotide binding]; other site
290512004480	putative Zn2+ binding site [ion binding]; other site
290512004481	AsnC family; Region: AsnC_trans_reg; pfam01037
290512004482	phytoene desaturase; Region: phytoene_desat; TIGR02731
290512004483	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290512004484	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
290512004485	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
290512004486	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
290512004487	Probable Catalytic site; other site
290512004488	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290512004489	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290512004490	active site
290512004491	phosphorylation site [posttranslational modification]
290512004492	intermolecular recognition site; other site
290512004493	dimerization interface [polypeptide binding]; other site
290512004494	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290512004495	Walker A motif; other site
290512004496	ATP binding site [chemical binding]; other site
290512004497	Walker B motif; other site
290512004498	arginine finger; other site
290512004499	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290512004500	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
290512004501	trimer interface [polypeptide binding]; other site
290512004502	active site
290512004503	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
290512004504	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
290512004505	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290512004506	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
290512004507	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
290512004508	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
290512004509	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
290512004510	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
290512004511	putative NAD(P) binding site [chemical binding]; other site
290512004512	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
290512004513	chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016
290512004514	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290512004515	DNA binding residues [nucleotide binding]
290512004516	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
290512004517	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
290512004518	G1 box; other site
290512004519	putative GEF interaction site [polypeptide binding]; other site
290512004520	GTP/Mg2+ binding site [chemical binding]; other site
290512004521	Switch I region; other site
290512004522	G2 box; other site
290512004523	G3 box; other site
290512004524	Switch II region; other site
290512004525	G4 box; other site
290512004526	G5 box; other site
290512004527	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
290512004528	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
290512004529	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
290512004530	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
290512004531	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
290512004532	tRNA; other site
290512004533	putative tRNA binding site [nucleotide binding]; other site
290512004534	putative NADP binding site [chemical binding]; other site
290512004535	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
290512004536	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
290512004537	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
290512004538	domain interfaces; other site
290512004539	active site
290512004540	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
290512004541	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
290512004542	active site
290512004543	RmuC family; Region: RmuC; pfam02646
290512004544	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
290512004545	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
290512004546	active site
290512004547	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
290512004548	nucleoside/Zn binding site; other site
290512004549	dimer interface [polypeptide binding]; other site
290512004550	catalytic motif [active]
290512004551	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
290512004552	dimer interface [polypeptide binding]; other site
290512004553	active site
290512004554	aspartate-rich active site metal binding site; other site
290512004555	allosteric magnesium binding site [ion binding]; other site
290512004556	Schiff base residues; other site
290512004557	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
290512004558	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
290512004559	Tetramer interface [polypeptide binding]; other site
290512004560	active site
290512004561	FMN-binding site [chemical binding]; other site
290512004562	serine acetyltransferase; Provisional; Region: cysE; PRK11132
290512004563	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
290512004564	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
290512004565	trimer interface [polypeptide binding]; other site
290512004566	active site
290512004567	substrate binding site [chemical binding]; other site
290512004568	CoA binding site [chemical binding]; other site
290512004569	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
290512004570	active site
290512004571	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
290512004572	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
290512004573	Coenzyme A binding pocket [chemical binding]; other site
290512004574	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
290512004575	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
290512004576	Protein of unknown function DUF89; Region: DUF89; cl15397
290512004577	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
290512004578	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
290512004579	ATP binding site [chemical binding]; other site
290512004580	Mg++ binding site [ion binding]; other site
290512004581	motif III; other site
290512004582	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290512004583	nucleotide binding region [chemical binding]; other site
290512004584	ATP-binding site [chemical binding]; other site
290512004585	Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
290512004586	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512004587	FeS/SAM binding site; other site
290512004588	PUCC protein; Region: PUCC; pfam03209
290512004589	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290512004590	putative substrate translocation pore; other site
290512004591	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
290512004592	ThiC-associated domain; Region: ThiC-associated; pfam13667
290512004593	ThiC family; Region: ThiC; pfam01964
290512004594	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
290512004595	triosephosphate isomerase; Provisional; Region: PRK14565
290512004596	substrate binding site [chemical binding]; other site
290512004597	dimer interface [polypeptide binding]; other site
290512004598	catalytic triad [active]
290512004599	Sm and related proteins; Region: Sm_like; cl00259
290512004600	heptamer interface [polypeptide binding]; other site
290512004601	Sm1 motif; other site
290512004602	hexamer interface [polypeptide binding]; other site
290512004603	RNA binding site [nucleotide binding]; other site
290512004604	Sm2 motif; other site
290512004605	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
290512004606	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
290512004607	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
290512004608	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
290512004609	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
290512004610	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
290512004611	protein binding site [polypeptide binding]; other site
290512004612	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
290512004613	protein binding site [polypeptide binding]; other site
290512004614	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
290512004615	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
290512004616	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
290512004617	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
290512004618	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
290512004619	Catalytic site [active]
290512004620	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
290512004621	GTP-binding protein LepA; Provisional; Region: PRK05433
290512004622	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
290512004623	G1 box; other site
290512004624	putative GEF interaction site [polypeptide binding]; other site
290512004625	GTP/Mg2+ binding site [chemical binding]; other site
290512004626	Switch I region; other site
290512004627	G2 box; other site
290512004628	G3 box; other site
290512004629	Switch II region; other site
290512004630	G4 box; other site
290512004631	G5 box; other site
290512004632	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
290512004633	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
290512004634	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
290512004635	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
290512004636	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
290512004637	putative active site [active]
290512004638	substrate binding site [chemical binding]; other site
290512004639	putative cosubstrate binding site; other site
290512004640	catalytic site [active]
290512004641	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
290512004642	substrate binding site [chemical binding]; other site
290512004643	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
290512004644	active site
290512004645	catalytic residues [active]
290512004646	metal binding site [ion binding]; metal-binding site
290512004647	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
290512004648	Mechanosensitive ion channel; Region: MS_channel; pfam00924
290512004649	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
290512004650	metal binding site 2 [ion binding]; metal-binding site
290512004651	putative DNA binding helix; other site
290512004652	metal binding site 1 [ion binding]; metal-binding site
290512004653	dimer interface [polypeptide binding]; other site
290512004654	structural Zn2+ binding site [ion binding]; other site
290512004655	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
290512004656	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
290512004657	gamma-glutamyl kinase; Provisional; Region: PRK05429
290512004658	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
290512004659	nucleotide binding site [chemical binding]; other site
290512004660	homotetrameric interface [polypeptide binding]; other site
290512004661	putative phosphate binding site [ion binding]; other site
290512004662	putative allosteric binding site; other site
290512004663	PUA domain; Region: PUA; pfam01472
290512004664	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
290512004665	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
290512004666	putative catalytic cysteine [active]
290512004667	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
290512004668	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
290512004669	Walker A/P-loop; other site
290512004670	ATP binding site [chemical binding]; other site
290512004671	Q-loop/lid; other site
290512004672	ABC transporter signature motif; other site
290512004673	Walker B; other site
290512004674	D-loop; other site
290512004675	H-loop/switch region; other site
290512004676	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290512004677	Major Facilitator Superfamily; Region: MFS_1; pfam07690
290512004678	putative substrate translocation pore; other site
290512004679	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
290512004680	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
290512004681	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
290512004682	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
290512004683	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
290512004684	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
290512004685	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
290512004686	Flavodoxin domain; Region: Flavodoxin_5; cl17428
290512004687	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
290512004688	chaperone protein DnaJ; Provisional; Region: PRK14281
290512004689	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
290512004690	HSP70 interaction site [polypeptide binding]; other site
290512004691	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
290512004692	substrate binding site [polypeptide binding]; other site
290512004693	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
290512004694	Zn binding sites [ion binding]; other site
290512004695	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
290512004696	dimer interface [polypeptide binding]; other site
290512004697	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
290512004698	dimer interface [polypeptide binding]; other site
290512004699	GrpE; Region: GrpE; pfam01025
290512004700	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
290512004701	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
290512004702	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
290512004703	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
290512004704	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290512004705	S-adenosylmethionine binding site [chemical binding]; other site
290512004706	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
290512004707	prolyl-tRNA synthetase; Provisional; Region: PRK08661
290512004708	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
290512004709	dimer interface [polypeptide binding]; other site
290512004710	motif 1; other site
290512004711	active site
290512004712	motif 2; other site
290512004713	motif 3; other site
290512004714	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
290512004715	anticodon binding site; other site
290512004716	zinc-binding site [ion binding]; other site
290512004717	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
290512004718	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
290512004719	dimer interface [polypeptide binding]; other site
290512004720	decamer (pentamer of dimers) interface [polypeptide binding]; other site
290512004721	catalytic triad [active]
290512004722	peroxidatic and resolving cysteines [active]
290512004723	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
290512004724	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586
290512004725	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
290512004726	putative active site [active]
290512004727	catalytic triad [active]
290512004728	putative dimer interface [polypeptide binding]; other site
290512004729	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14616
290512004730	Sporulation related domain; Region: SPOR; pfam05036
290512004731	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
290512004732	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290512004733	Walker A motif; other site
290512004734	ATP binding site [chemical binding]; other site
290512004735	Walker B motif; other site
290512004736	arginine finger; other site
290512004737	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290512004738	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
290512004739	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
290512004740	putative active site [active]
290512004741	catalytic triad [active]
290512004742	putative dimer interface [polypeptide binding]; other site
290512004743	Bacteriochlorophyll A protein; Region: BChl_A; pfam02327
290512004744	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
290512004745	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
290512004746	DNA binding residues [nucleotide binding]
290512004747	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
290512004748	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
290512004749	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290512004750	Walker A/P-loop; other site
290512004751	ATP binding site [chemical binding]; other site
290512004752	Q-loop/lid; other site
290512004753	ABC transporter signature motif; other site
290512004754	Walker B; other site
290512004755	D-loop; other site
290512004756	H-loop/switch region; other site
290512004757	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
290512004758	B12 binding site [chemical binding]; other site
290512004759	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
290512004760	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512004761	FeS/SAM binding site; other site
290512004762	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
290512004763	MutS domain I; Region: MutS_I; pfam01624
290512004764	MutS domain II; Region: MutS_II; pfam05188
290512004765	MutS domain III; Region: MutS_III; pfam05192
290512004766	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
290512004767	Walker A/P-loop; other site
290512004768	ATP binding site [chemical binding]; other site
290512004769	Q-loop/lid; other site
290512004770	ABC transporter signature motif; other site
290512004771	Walker B; other site
290512004772	D-loop; other site
290512004773	H-loop/switch region; other site
290512004774	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
290512004775	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
290512004776	malate dehydrogenase; Reviewed; Region: PRK06223
290512004777	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
290512004778	NAD(P) binding site [chemical binding]; other site
290512004779	dimer interface [polypeptide binding]; other site
290512004780	tetramer (dimer of dimers) interface [polypeptide binding]; other site
290512004781	substrate binding site [chemical binding]; other site
290512004782	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
290512004783	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
290512004784	Peptidase family M48; Region: Peptidase_M48; pfam01435
290512004785	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
290512004786	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
290512004787	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
290512004788	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
290512004789	putative active site; other site
290512004790	catalytic triad [active]
290512004791	putative dimer interface [polypeptide binding]; other site
290512004792	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
290512004793	UbiA prenyltransferase family; Region: UbiA; pfam01040
290512004794	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
290512004795	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
290512004796	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
290512004797	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
290512004798	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
290512004799	substrate binding site [chemical binding]; other site
290512004800	glutamase interaction surface [polypeptide binding]; other site
290512004801	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
290512004802	Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350
290512004803	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
290512004804	iron-sulfur cluster [ion binding]; other site
290512004805	[2Fe-2S] cluster binding site [ion binding]; other site
290512004806	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
290512004807	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
290512004808	oligomer interface [polypeptide binding]; other site
290512004809	metal binding site [ion binding]; metal-binding site
290512004810	metal binding site [ion binding]; metal-binding site
290512004811	Cl binding site [ion binding]; other site
290512004812	aspartate ring; other site
290512004813	basic sphincter; other site
290512004814	putative hydrophobic gate; other site
290512004815	periplasmic entrance; other site
290512004816	Domain of unknown function (DUF389); Region: DUF389; cl00781
290512004817	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
290512004818	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
290512004819	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
290512004820	putative phosphoketolase; Provisional; Region: PRK05261
290512004821	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
290512004822	TPP-binding site; other site
290512004823	XFP C-terminal domain; Region: XFP_C; pfam09363
290512004824	propionate/acetate kinase; Provisional; Region: PRK12379
290512004825	Acetokinase family; Region: Acetate_kinase; cl17229
290512004826	Superinfection immunity protein; Region: Imm_superinfect; pfam14373
290512004827	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
290512004828	active site
290512004829	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
290512004830	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
290512004831	active site
290512004832	catalytic residues [active]
290512004833	metal binding site [ion binding]; metal-binding site
290512004834	Nif-specific regulatory protein; Region: nifA; TIGR01817
290512004835	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
290512004836	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290512004837	Walker A motif; other site
290512004838	ATP binding site [chemical binding]; other site
290512004839	Walker B motif; other site
290512004840	arginine finger; other site
290512004841	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290512004842	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
290512004843	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
290512004844	nitrogenase reductase; Reviewed; Region: nifH; PRK13235
290512004845	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
290512004846	Nucleotide-binding sites [chemical binding]; other site
290512004847	Walker A motif; other site
290512004848	Switch I region of nucleotide binding site; other site
290512004849	Fe4S4 binding sites [ion binding]; other site
290512004850	Switch II region of nucleotide binding site; other site
290512004851	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
290512004852	Nitrogen regulatory protein P-II; Region: P-II; smart00938
290512004853	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
290512004854	Nitrogen regulatory protein P-II; Region: P-II; smart00938
290512004855	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
290512004856	MoFe protein alpha/beta subunit interactions; other site
290512004857	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
290512004858	Alpha subunit P cluster binding residues; other site
290512004859	FeMoco binding residues [chemical binding]; other site
290512004860	MoFe protein alpha subunit/Fe protein contacts; other site
290512004861	MoFe protein dimer/ dimer interactions; other site
290512004862	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
290512004863	MoFe protein beta/alpha subunit interactions; other site
290512004864	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
290512004865	Beta subunit P cluster binding residues; other site
290512004866	MoFe protein beta subunit/Fe protein contacts; other site
290512004867	MoFe protein dimer/ dimer interactions; other site
290512004868	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
290512004869	Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN.  NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968
290512004870	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
290512004871	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
290512004872	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
290512004873	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512004874	FeS/SAM binding site; other site
290512004875	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
290512004876	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
290512004877	dimer interface [polypeptide binding]; other site
290512004878	[2Fe-2S] cluster binding site [ion binding]; other site
290512004879	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
290512004880	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
290512004881	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
290512004882	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290512004883	dimer interface [polypeptide binding]; other site
290512004884	conserved gate region; other site
290512004885	putative PBP binding loops; other site
290512004886	ABC-ATPase subunit interface; other site
290512004887	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
290512004888	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
290512004889	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
290512004890	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
290512004891	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
290512004892	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290512004893	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290512004894	dimer interface [polypeptide binding]; other site
290512004895	phosphorylation site [posttranslational modification]
290512004896	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290512004897	ATP binding site [chemical binding]; other site
290512004898	Mg2+ binding site [ion binding]; other site
290512004899	G-X-G motif; other site
290512004900	Response regulator receiver domain; Region: Response_reg; pfam00072
290512004901	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290512004902	active site
290512004903	phosphorylation site [posttranslational modification]
290512004904	intermolecular recognition site; other site
290512004905	dimerization interface [polypeptide binding]; other site
290512004906	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
290512004907	dimerization interface [polypeptide binding]; other site
290512004908	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
290512004909	ATP binding site [chemical binding]; other site
290512004910	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
290512004911	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
290512004912	HupF/HypC family; Region: HupF_HypC; pfam01455
290512004913	Acylphosphatase; Region: Acylphosphatase; pfam00708
290512004914	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
290512004915	HypF finger; Region: zf-HYPF; pfam07503
290512004916	HypF finger; Region: zf-HYPF; pfam07503
290512004917	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
290512004918	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
290512004919	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
290512004920	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
290512004921	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
290512004922	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
290512004923	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
290512004924	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
290512004925	Protein of unknown function (DUF1207); Region: DUF1207; pfam06727
290512004926	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
290512004927	nudix motif; other site
290512004928	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
290512004929	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
290512004930	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
290512004931	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
290512004932	Na binding site [ion binding]; other site
290512004933	excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671
290512004934	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
290512004935	GIY-YIG motif/motif A; other site
290512004936	active site
290512004937	catalytic site [active]
290512004938	putative DNA binding site [nucleotide binding]; other site
290512004939	metal binding site [ion binding]; metal-binding site
290512004940	UvrB/uvrC motif; Region: UVR; pfam02151
290512004941	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
290512004942	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512004943	binding surface
290512004944	TPR motif; other site
290512004945	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512004946	binding surface
290512004947	TPR repeat; Region: TPR_11; pfam13414
290512004948	TPR motif; other site
290512004949	TPR repeat; Region: TPR_11; pfam13414
290512004950	TPR repeat; Region: TPR_11; pfam13414
290512004951	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512004952	binding surface
290512004953	TPR motif; other site
290512004954	TPR repeat; Region: TPR_11; pfam13414
290512004955	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512004956	binding surface
290512004957	TPR motif; other site
290512004958	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512004959	binding surface
290512004960	TPR motif; other site
290512004961	TPR repeat; Region: TPR_11; pfam13414
290512004962	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
290512004963	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
290512004964	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
290512004965	shikimate binding site; other site
290512004966	NAD(P) binding site [chemical binding]; other site
290512004967	lipoprotein signal peptidase; Provisional; Region: PRK14787
290512004968	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
290512004969	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
290512004970	active site
290512004971	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
290512004972	active site
290512004973	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
290512004974	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
290512004975	catalytic residue [active]
290512004976	alanine aminotransferase; Validated; Region: PRK08363
290512004977	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290512004978	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290512004979	homodimer interface [polypeptide binding]; other site
290512004980	catalytic residue [active]
290512004981	purine nucleoside phosphorylase; Provisional; Region: PRK08202
290512004982	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
290512004983	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
290512004984	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
290512004985	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
290512004986	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
290512004987	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
290512004988	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
290512004989	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290512004990	Walker A/P-loop; other site
290512004991	ATP binding site [chemical binding]; other site
290512004992	Q-loop/lid; other site
290512004993	ABC transporter signature motif; other site
290512004994	Walker B; other site
290512004995	D-loop; other site
290512004996	H-loop/switch region; other site
290512004997	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
290512004998	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
290512004999	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290512005000	Walker A/P-loop; other site
290512005001	ATP binding site [chemical binding]; other site
290512005002	Q-loop/lid; other site
290512005003	ABC transporter signature motif; other site
290512005004	Walker B; other site
290512005005	D-loop; other site
290512005006	H-loop/switch region; other site
290512005007	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
290512005008	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
290512005009	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
290512005010	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
290512005011	putative active site [active]
290512005012	putative substrate binding site [chemical binding]; other site
290512005013	putative cosubstrate binding site; other site
290512005014	catalytic site [active]
290512005015	PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389
290512005016	active site
290512005017	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
290512005018	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
290512005019	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
290512005020	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
290512005021	Ligand binding site; other site
290512005022	Putative Catalytic site; other site
290512005023	DXD motif; other site
290512005024	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
290512005025	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
290512005026	DHH family; Region: DHH; pfam01368
290512005027	DHHA1 domain; Region: DHHA1; pfam02272
290512005028	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
290512005029	AMP binding site [chemical binding]; other site
290512005030	metal binding site [ion binding]; metal-binding site
290512005031	active site
290512005032	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
290512005033	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
290512005034	putative active site [active]
290512005035	metal binding site [ion binding]; metal-binding site
290512005036	homodimer binding site [polypeptide binding]; other site
290512005037	Pirin-related protein [General function prediction only]; Region: COG1741
290512005038	Pirin; Region: Pirin; pfam02678
290512005039	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
290512005040	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
290512005041	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
290512005042	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
290512005043	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
290512005044	NAD binding site [chemical binding]; other site
290512005045	homotetramer interface [polypeptide binding]; other site
290512005046	homodimer interface [polypeptide binding]; other site
290512005047	substrate binding site [chemical binding]; other site
290512005048	active site
290512005049	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
290512005050	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
290512005051	P loop; other site
290512005052	Nucleotide binding site [chemical binding]; other site
290512005053	DTAP/Switch II; other site
290512005054	Switch I; other site
290512005055	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
290512005056	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
290512005057	Flavoprotein; Region: Flavoprotein; cl08021
290512005058	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
290512005059	Part of AAA domain; Region: AAA_19; pfam13245
290512005060	Family description; Region: UvrD_C_2; pfam13538
290512005061	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
290512005062	aromatic arch; other site
290512005063	DCoH dimer interaction site [polypeptide binding]; other site
290512005064	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
290512005065	DCoH tetramer interaction site [polypeptide binding]; other site
290512005066	substrate binding site [chemical binding]; other site
290512005067	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347
290512005068	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
290512005069	active site
290512005070	catalytic site [active]
290512005071	Uncharacterized conserved protein [Function unknown]; Region: COG0432
290512005072	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
290512005073	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
290512005074	TPP-binding site; other site
290512005075	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
290512005076	PYR/PP interface [polypeptide binding]; other site
290512005077	dimer interface [polypeptide binding]; other site
290512005078	TPP binding site [chemical binding]; other site
290512005079	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
290512005080	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
290512005081	tetramer interfaces [polypeptide binding]; other site
290512005082	binuclear metal-binding site [ion binding]; other site
290512005083	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
290512005084	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
290512005085	MutS domain III; Region: MutS_III; pfam05192
290512005086	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
290512005087	Walker A/P-loop; other site
290512005088	ATP binding site [chemical binding]; other site
290512005089	Q-loop/lid; other site
290512005090	ABC transporter signature motif; other site
290512005091	Walker B; other site
290512005092	D-loop; other site
290512005093	H-loop/switch region; other site
290512005094	Smr domain; Region: Smr; pfam01713
290512005095	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
290512005096	active site
290512005097	hydrophilic channel; other site
290512005098	dimerization interface [polypeptide binding]; other site
290512005099	catalytic residues [active]
290512005100	active site lid [active]
290512005101	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
290512005102	active site
290512005103	dimerization interface [polypeptide binding]; other site
290512005104	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
290512005105	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
290512005106	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
290512005107	active site
290512005108	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
290512005109	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
290512005110	Permease; Region: Permease; pfam02405
290512005111	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
290512005112	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
290512005113	Walker A/P-loop; other site
290512005114	ATP binding site [chemical binding]; other site
290512005115	Q-loop/lid; other site
290512005116	ABC transporter signature motif; other site
290512005117	Walker B; other site
290512005118	D-loop; other site
290512005119	H-loop/switch region; other site
290512005120	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
290512005121	mce related protein; Region: MCE; pfam02470
290512005122	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
290512005123	Beta-lactamase; Region: Beta-lactamase; pfam00144
290512005124	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290512005125	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
290512005126	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
290512005127	iron-sulfur cluster [ion binding]; other site
290512005128	[2Fe-2S] cluster binding site [ion binding]; other site
290512005129	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
290512005130	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
290512005131	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
290512005132	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
290512005133	purine monophosphate binding site [chemical binding]; other site
290512005134	dimer interface [polypeptide binding]; other site
290512005135	putative catalytic residues [active]
290512005136	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
290512005137	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
290512005138	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
290512005139	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
290512005140	active site
290512005141	substrate binding site [chemical binding]; other site
290512005142	cosubstrate binding site; other site
290512005143	catalytic site [active]
290512005144	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
290512005145	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
290512005146	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
290512005147	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
290512005148	Ligand binding site; other site
290512005149	Putative Catalytic site; other site
290512005150	DXD motif; other site
290512005151	endonuclease IV; Provisional; Region: PRK01060
290512005152	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
290512005153	AP (apurinic/apyrimidinic) site pocket; other site
290512005154	DNA interaction; other site
290512005155	Metal-binding active site; metal-binding site
290512005156	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
290512005157	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
290512005158	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
290512005159	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
290512005160	active site
290512005161	tetramer interface [polypeptide binding]; other site
290512005162	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
290512005163	active site
290512005164	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
290512005165	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
290512005166	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
290512005167	active site
290512005168	HIGH motif; other site
290512005169	nucleotide binding site [chemical binding]; other site
290512005170	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
290512005171	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
290512005172	active site
290512005173	KMSKS motif; other site
290512005174	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
290512005175	tRNA binding surface [nucleotide binding]; other site
290512005176	anticodon binding site; other site
290512005177	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
290512005178	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
290512005179	VirB7 interaction site; other site
290512005180	VirB8 protein; Region: VirB8; cl01500
290512005181	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
290512005182	conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193
290512005183	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
290512005184	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
290512005185	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290512005186	Walker A/P-loop; other site
290512005187	ATP binding site [chemical binding]; other site
290512005188	Q-loop/lid; other site
290512005189	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
290512005190	TrbC/VIRB2 family; Region: TrbC; pfam04956
290512005191	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
290512005192	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
290512005193	Walker A motif; other site
290512005194	ATP binding site [chemical binding]; other site
290512005195	Walker B motif; other site
290512005196	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
290512005197	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
290512005198	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
290512005199	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
290512005200	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
290512005201	NAD binding site [chemical binding]; other site
290512005202	substrate binding site [chemical binding]; other site
290512005203	homodimer interface [polypeptide binding]; other site
290512005204	active site
290512005205	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
290512005206	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
290512005207	NADP binding site [chemical binding]; other site
290512005208	active site
290512005209	putative substrate binding site [chemical binding]; other site
290512005210	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
290512005211	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
290512005212	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
290512005213	substrate binding site; other site
290512005214	tetramer interface; other site
290512005215	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
290512005216	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
290512005217	Substrate binding site; other site
290512005218	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
290512005219	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
290512005220	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
290512005221	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
290512005222	putative active site [active]
290512005223	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
290512005224	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
290512005225	active site
290512005226	substrate binding site [chemical binding]; other site
290512005227	metal binding site [ion binding]; metal-binding site
290512005228	Fic/DOC family; Region: Fic; pfam02661
290512005229	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
290512005230	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
290512005231	putative active site [active]
290512005232	homotetrameric interface [polypeptide binding]; other site
290512005233	metal binding site [ion binding]; metal-binding site
290512005234	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
290512005235	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
290512005236	glutaminase active site [active]
290512005237	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
290512005238	dimer interface [polypeptide binding]; other site
290512005239	active site
290512005240	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
290512005241	dimer interface [polypeptide binding]; other site
290512005242	active site
290512005243	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290512005244	Ligand Binding Site [chemical binding]; other site
290512005245	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
290512005246	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
290512005247	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
290512005248	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290512005249	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
290512005250	active site
290512005251	motif I; other site
290512005252	motif II; other site
290512005253	WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915
290512005254	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
290512005255	Substrate binding site; other site
290512005256	Mg++ binding site; other site
290512005257	metal-binding site
290512005258	Mg++ binding site; other site
290512005259	metal-binding site
290512005260	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
290512005261	dimer interface [polypeptide binding]; other site
290512005262	active site
290512005263	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
290512005264	ligand-binding site [chemical binding]; other site
290512005265	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
290512005266	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290512005267	NAD(P) binding site [chemical binding]; other site
290512005268	active site
290512005269	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
290512005270	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
290512005271	TrkA-C domain; Region: TrkA_C; pfam02080
290512005272	TrkA-C domain; Region: TrkA_C; pfam02080
290512005273	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
290512005274	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
290512005275	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
290512005276	active site
290512005277	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
290512005278	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
290512005279	CysD dimerization site [polypeptide binding]; other site
290512005280	G1 box; other site
290512005281	putative GEF interaction site [polypeptide binding]; other site
290512005282	GTP/Mg2+ binding site [chemical binding]; other site
290512005283	Switch I region; other site
290512005284	G2 box; other site
290512005285	G3 box; other site
290512005286	Switch II region; other site
290512005287	G4 box; other site
290512005288	G5 box; other site
290512005289	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
290512005290	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
290512005291	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
290512005292	ligand-binding site [chemical binding]; other site
290512005293	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
290512005294	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
290512005295	Active Sites [active]
290512005296	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290512005297	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
290512005298	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
290512005299	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
290512005300	CysD dimerization site [polypeptide binding]; other site
290512005301	G1 box; other site
290512005302	putative GEF interaction site [polypeptide binding]; other site
290512005303	GTP/Mg2+ binding site [chemical binding]; other site
290512005304	Switch I region; other site
290512005305	G2 box; other site
290512005306	G3 box; other site
290512005307	Switch II region; other site
290512005308	G4 box; other site
290512005309	G5 box; other site
290512005310	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
290512005311	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
290512005312	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
290512005313	ligand-binding site [chemical binding]; other site
290512005314	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
290512005315	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
290512005316	Active Sites [active]
290512005317	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
290512005318	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
290512005319	NAD binding site [chemical binding]; other site
290512005320	substrate binding site [chemical binding]; other site
290512005321	homodimer interface [polypeptide binding]; other site
290512005322	active site
290512005323	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
290512005324	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
290512005325	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
290512005326	substrate binding site; other site
290512005327	tetramer interface; other site
290512005328	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
290512005329	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
290512005330	active site
290512005331	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
290512005332	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
290512005333	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
290512005334	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
290512005335	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
290512005336	four helix bundle protein; Region: TIGR02436
290512005337	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
290512005338	Mg++ binding site [ion binding]; other site
290512005339	putative catalytic motif [active]
290512005340	substrate binding site [chemical binding]; other site
290512005341	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
290512005342	four helix bundle protein; Region: TIGR02436
290512005343	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
290512005344	four helix bundle protein; Region: TIGR02436
290512005345	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
290512005346	Chain length determinant protein; Region: Wzz; pfam02706
290512005347	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
290512005348	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
290512005349	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
290512005350	Magnesium ion binding site [ion binding]; other site
290512005351	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
290512005352	four helix bundle protein; Region: TIGR02436
290512005353	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
290512005354	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
290512005355	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
290512005356	active site
290512005357	catalytic site [active]
290512005358	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
290512005359	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
290512005360	intrachain domain interface; other site
290512005361	interchain domain interface [polypeptide binding]; other site
290512005362	heme bL binding site [chemical binding]; other site
290512005363	heme bH binding site [chemical binding]; other site
290512005364	Qo binding site; other site
290512005365	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
290512005366	interchain domain interface [polypeptide binding]; other site
290512005367	intrachain domain interface; other site
290512005368	Qi binding site; other site
290512005369	Qo binding site; other site
290512005370	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
290512005371	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
290512005372	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
290512005373	iron-sulfur cluster [ion binding]; other site
290512005374	[2Fe-2S] cluster binding site [ion binding]; other site
290512005375	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
290512005376	Transposase IS200 like; Region: Y1_Tnp; cl00848
290512005377	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
290512005378	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
290512005379	HIGH motif; other site
290512005380	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
290512005381	active site
290512005382	KMSKS motif; other site
290512005383	FtsH Extracellular; Region: FtsH_ext; pfam06480
290512005384	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
290512005385	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290512005386	Walker B motif; other site
290512005387	arginine finger; other site
290512005388	Peptidase family M41; Region: Peptidase_M41; pfam01434
290512005389	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
290512005390	IHF dimer interface [polypeptide binding]; other site
290512005391	IHF - DNA interface [nucleotide binding]; other site
290512005392	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
290512005393	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
290512005394	transmembrane helices; other site
290512005395	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
290512005396	active site
290512005397	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
290512005398	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
290512005399	AAA domain; Region: AAA_32; pfam13654
290512005400	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
290512005401	GTPase Era; Reviewed; Region: era; PRK00089
290512005402	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
290512005403	G1 box; other site
290512005404	GTP/Mg2+ binding site [chemical binding]; other site
290512005405	Switch I region; other site
290512005406	G2 box; other site
290512005407	Switch II region; other site
290512005408	G3 box; other site
290512005409	G4 box; other site
290512005410	G5 box; other site
290512005411	KH domain; Region: KH_2; pfam07650
290512005412	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
290512005413	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
290512005414	RNA binding site [nucleotide binding]; other site
290512005415	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
290512005416	RNA binding site [nucleotide binding]; other site
290512005417	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
290512005418	RNA binding site [nucleotide binding]; other site
290512005419	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
290512005420	RNA binding site [nucleotide binding]; other site
290512005421	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
290512005422	RNA binding site [nucleotide binding]; other site
290512005423	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
290512005424	RNA binding site [nucleotide binding]; other site
290512005425	GTP-binding protein YchF; Reviewed; Region: PRK09601
290512005426	YchF GTPase; Region: YchF; cd01900
290512005427	G1 box; other site
290512005428	GTP/Mg2+ binding site [chemical binding]; other site
290512005429	Switch I region; other site
290512005430	G2 box; other site
290512005431	Switch II region; other site
290512005432	G3 box; other site
290512005433	G4 box; other site
290512005434	G5 box; other site
290512005435	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
290512005436	glutamate racemase; Provisional; Region: PRK00865
290512005437	short chain dehydrogenase; Provisional; Region: PRK06197
290512005438	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
290512005439	putative NAD(P) binding site [chemical binding]; other site
290512005440	active site
290512005441	Lipopolysaccharide-assembly; Region: LptE; cl01125
290512005442	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
290512005443	classical (c) SDRs; Region: SDR_c; cd05233
290512005444	NAD(P) binding site [chemical binding]; other site
290512005445	active site
290512005446	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
290512005447	Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850
290512005448	dimer interface [polypeptide binding]; other site
290512005449	catalytic residue [active]
290512005450	metal binding site [ion binding]; metal-binding site
290512005451	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
290512005452	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
290512005453	putative active site; other site
290512005454	catalytic residue [active]
290512005455	short chain dehydrogenase; Validated; Region: PRK08324
290512005456	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
290512005457	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943
290512005458	putative NAD(P) binding site [chemical binding]; other site
290512005459	active site
290512005460	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
290512005461	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
290512005462	B12 binding site [chemical binding]; other site
290512005463	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
290512005464	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512005465	FeS/SAM binding site; other site
290512005466	recombination regulator RecX; Reviewed; Region: recX; PRK00117
290512005467	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
290512005468	putative nucleotide binding site [chemical binding]; other site
290512005469	uridine monophosphate binding site [chemical binding]; other site
290512005470	homohexameric interface [polypeptide binding]; other site
290512005471	elongation factor Ts; Provisional; Region: tsf; PRK09377
290512005472	UBA/TS-N domain; Region: UBA; pfam00627
290512005473	Elongation factor TS; Region: EF_TS; pfam00889
290512005474	Elongation factor TS; Region: EF_TS; pfam00889
290512005475	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
290512005476	rRNA interaction site [nucleotide binding]; other site
290512005477	S8 interaction site; other site
290512005478	putative laminin-1 binding site; other site
290512005479	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
290512005480	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
290512005481	23S rRNA interface [nucleotide binding]; other site
290512005482	L3 interface [polypeptide binding]; other site
290512005483	GTP-binding protein Der; Reviewed; Region: PRK00093
290512005484	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
290512005485	G1 box; other site
290512005486	GTP/Mg2+ binding site [chemical binding]; other site
290512005487	Switch I region; other site
290512005488	G2 box; other site
290512005489	Switch II region; other site
290512005490	G3 box; other site
290512005491	G4 box; other site
290512005492	G5 box; other site
290512005493	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
290512005494	G1 box; other site
290512005495	GTP/Mg2+ binding site [chemical binding]; other site
290512005496	Switch I region; other site
290512005497	G2 box; other site
290512005498	G3 box; other site
290512005499	Switch II region; other site
290512005500	G4 box; other site
290512005501	G5 box; other site
290512005502	antiporter inner membrane protein; Provisional; Region: PRK11670
290512005503	Domain of unknown function DUF59; Region: DUF59; pfam01883
290512005504	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
290512005505	Walker A motif; other site
290512005506	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
290512005507	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
290512005508	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
290512005509	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
290512005510	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
290512005511	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
290512005512	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
290512005513	TPR repeat; Region: TPR_11; pfam13414
290512005514	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512005515	TPR motif; other site
290512005516	binding surface
290512005517	TPR repeat; Region: TPR_11; pfam13414
290512005518	Repair protein; Region: Repair_PSII; cl01535
290512005519	Repair protein; Region: Repair_PSII; pfam04536
290512005520	LemA family; Region: LemA; pfam04011
290512005521	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
290512005522	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
290512005523	Zn2+ binding site [ion binding]; other site
290512005524	Mg2+ binding site [ion binding]; other site
290512005525	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
290512005526	synthetase active site [active]
290512005527	NTP binding site [chemical binding]; other site
290512005528	metal binding site [ion binding]; metal-binding site
290512005529	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
290512005530	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
290512005531	excinuclease ABC subunit B; Provisional; Region: PRK05298
290512005532	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290512005533	ATP binding site [chemical binding]; other site
290512005534	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290512005535	nucleotide binding region [chemical binding]; other site
290512005536	ATP-binding site [chemical binding]; other site
290512005537	Ultra-violet resistance protein B; Region: UvrB; pfam12344
290512005538	UvrB/uvrC motif; Region: UVR; pfam02151
290512005539	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
290512005540	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
290512005541	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
290512005542	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
290512005543	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
290512005544	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_1; cd03400
290512005545	Predicted permeases [General function prediction only]; Region: COG0795
290512005546	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
290512005547	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
290512005548	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
290512005549	TrkA-N domain; Region: TrkA_N; pfam02254
290512005550	TrkA-C domain; Region: TrkA_C; pfam02080
290512005551	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
290512005552	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
290512005553	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
290512005554	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
290512005555	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290512005556	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
290512005557	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290512005558	DNA binding residues [nucleotide binding]
290512005559	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
290512005560	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
290512005561	active site
290512005562	HIGH motif; other site
290512005563	nucleotide binding site [chemical binding]; other site
290512005564	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
290512005565	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
290512005566	active site
290512005567	KMSKS motif; other site
290512005568	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
290512005569	tRNA binding surface [nucleotide binding]; other site
290512005570	anticodon binding site; other site
290512005571	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
290512005572	Clp protease; Region: CLP_protease; pfam00574
290512005573	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
290512005574	oligomer interface [polypeptide binding]; other site
290512005575	active site residues [active]
290512005576	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
290512005577	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
290512005578	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
290512005579	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
290512005580	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
290512005581	active site
290512005582	nucleophile elbow; other site
290512005583	Surface antigen; Region: Bac_surface_Ag; pfam01103
290512005584	stationary phase survival protein SurE; Provisional; Region: PRK13932
290512005585	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079
290512005586	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
290512005587	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
290512005588	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
290512005589	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
290512005590	DsbD alpha interface [polypeptide binding]; other site
290512005591	catalytic residues [active]
290512005592	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
290512005593	ResB-like family; Region: ResB; pfam05140
290512005594	Predicted transcriptional regulator [General function prediction only]; Region: COG2522
290512005595	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290512005596	sequence-specific DNA binding site [nucleotide binding]; other site
290512005597	salt bridge; other site
290512005598	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
290512005599	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
290512005600	ATP binding site [chemical binding]; other site
290512005601	substrate interface [chemical binding]; other site
290512005602	Haem-binding domain; Region: Haem_bd; pfam14376
290512005603	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
290512005604	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
290512005605	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
290512005606	glutamine binding [chemical binding]; other site
290512005607	catalytic triad [active]
290512005608	Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562
290512005609	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991
290512005610	Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635
290512005611	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
290512005612	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
290512005613	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
290512005614	Low molecular weight phosphatase family; Region: LMWPc; cd00115
290512005615	active site
290512005616	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
290512005617	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
290512005618	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
290512005619	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
290512005620	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
290512005621	NAD(P) binding site [chemical binding]; other site
290512005622	catalytic residues [active]
290512005623	GTPase RsgA; Reviewed; Region: PRK00098
290512005624	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
290512005625	RNA binding site [nucleotide binding]; other site
290512005626	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
290512005627	GTPase/Zn-binding domain interface [polypeptide binding]; other site
290512005628	GTP/Mg2+ binding site [chemical binding]; other site
290512005629	G4 box; other site
290512005630	G5 box; other site
290512005631	G1 box; other site
290512005632	Switch I region; other site
290512005633	G2 box; other site
290512005634	G3 box; other site
290512005635	Switch II region; other site
290512005636	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
290512005637	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
290512005638	generic binding surface II; other site
290512005639	ssDNA binding site; other site
290512005640	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290512005641	ATP binding site [chemical binding]; other site
290512005642	putative Mg++ binding site [ion binding]; other site
290512005643	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290512005644	nucleotide binding region [chemical binding]; other site
290512005645	ATP-binding site [chemical binding]; other site
290512005646	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
290512005647	ribosome recycling factor; Reviewed; Region: frr; PRK00083
290512005648	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
290512005649	hinge region; other site
290512005650	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
290512005651	chlorophyllide reductase subunit Y; Region: BchY; TIGR02015
290512005652	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
290512005653	IHF dimer interface [polypeptide binding]; other site
290512005654	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
290512005655	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
290512005656	generic binding surface II; other site
290512005657	generic binding surface I; other site
290512005658	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
290512005659	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
290512005660	Ligand binding site; other site
290512005661	oligomer interface; other site
290512005662	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
290512005663	putative active site [active]
290512005664	dimerization interface [polypeptide binding]; other site
290512005665	putative tRNAtyr binding site [nucleotide binding]; other site
290512005666	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
290512005667	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
290512005668	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
290512005669	Citrate synthase; Region: Citrate_synt; pfam00285
290512005670	oxalacetate binding site [chemical binding]; other site
290512005671	citrylCoA binding site [chemical binding]; other site
290512005672	coenzyme A binding site [chemical binding]; other site
290512005673	catalytic triad [active]
290512005674	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
290512005675	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
290512005676	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
290512005677	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
290512005678	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
290512005679	Uncharacterized conserved protein [Function unknown]; Region: COG1432
290512005680	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
290512005681	putative metal binding site [ion binding]; other site
290512005682	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
290512005683	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
290512005684	TPR repeat; Region: TPR_11; pfam13414
290512005685	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512005686	binding surface
290512005687	TPR motif; other site
290512005688	TPR repeat; Region: TPR_11; pfam13414
290512005689	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512005690	binding surface
290512005691	TPR motif; other site
290512005692	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
290512005693	chorismate binding enzyme; Region: Chorismate_bind; cl10555
290512005694	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
290512005695	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
290512005696	dimer interface [polypeptide binding]; other site
290512005697	tetramer interface [polypeptide binding]; other site
290512005698	PYR/PP interface [polypeptide binding]; other site
290512005699	TPP binding site [chemical binding]; other site
290512005700	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
290512005701	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
290512005702	TPP-binding site; other site
290512005703	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
290512005704	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
290512005705	nucleophilic elbow; other site
290512005706	catalytic triad; other site
290512005707	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
290512005708	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
290512005709	substrate binding site [chemical binding]; other site
290512005710	oxyanion hole (OAH) forming residues; other site
290512005711	trimer interface [polypeptide binding]; other site
290512005712	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
290512005713	o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927
290512005714	active site
290512005715	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
290512005716	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
290512005717	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
290512005718	putative active site [active]
290512005719	putative CoA binding site [chemical binding]; other site
290512005720	putative AMP binding site [chemical binding]; other site
290512005721	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
290512005722	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
290512005723	FMN binding site [chemical binding]; other site
290512005724	active site
290512005725	substrate binding site [chemical binding]; other site
290512005726	catalytic residue [active]
290512005727	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
290512005728	dihydrodipicolinate reductase; Provisional; Region: PRK00048
290512005729	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
290512005730	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
290512005731	ParB-like nuclease domain; Region: ParB; smart00470
290512005732	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
290512005733	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
290512005734	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
290512005735	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
290512005736	P-loop; other site
290512005737	Magnesium ion binding site [ion binding]; other site
290512005738	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
290512005739	Magnesium ion binding site [ion binding]; other site
290512005740	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
290512005741	active site
290512005742	DNA binding site [nucleotide binding]
290512005743	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
290512005744	MgtE intracellular N domain; Region: MgtE_N; smart00924
290512005745	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
290512005746	Divalent cation transporter; Region: MgtE; pfam01769
290512005747	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
290512005748	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
290512005749	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
290512005750	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
290512005751	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
290512005752	Ligand Binding Site [chemical binding]; other site
290512005753	Predicted esterase [General function prediction only]; Region: COG0400
290512005754	Serine hydrolase (FSH1); Region: FSH1; pfam03959
290512005755	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
290512005756	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
290512005757	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
290512005758	substrate binding pocket [chemical binding]; other site
290512005759	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
290512005760	B12 binding site [chemical binding]; other site
290512005761	cobalt ligand [ion binding]; other site
290512005762	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
290512005763	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
290512005764	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
290512005765	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
290512005766	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
290512005767	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
290512005768	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
290512005769	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
290512005770	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
290512005771	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
290512005772	active site residue [active]
290512005773	Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042
290512005774	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
290512005775	Mechanosensitive ion channel; Region: MS_channel; pfam00924
290512005776	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
290512005777	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
290512005778	TPP-binding site [chemical binding]; other site
290512005779	dimer interface [polypeptide binding]; other site
290512005780	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
290512005781	PYR/PP interface [polypeptide binding]; other site
290512005782	dimer interface [polypeptide binding]; other site
290512005783	TPP binding site [chemical binding]; other site
290512005784	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
290512005785	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
290512005786	putative active site [active]
290512005787	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
290512005788	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
290512005789	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
290512005790	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
290512005791	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
290512005792	PAS fold; Region: PAS_4; pfam08448
290512005793	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
290512005794	putative active site [active]
290512005795	heme pocket [chemical binding]; other site
290512005796	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290512005797	dimer interface [polypeptide binding]; other site
290512005798	phosphorylation site [posttranslational modification]
290512005799	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290512005800	ATP binding site [chemical binding]; other site
290512005801	Mg2+ binding site [ion binding]; other site
290512005802	G-X-G motif; other site
290512005803	Response regulator receiver domain; Region: Response_reg; pfam00072
290512005804	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290512005805	active site
290512005806	phosphorylation site [posttranslational modification]
290512005807	intermolecular recognition site; other site
290512005808	dimerization interface [polypeptide binding]; other site
290512005809	Hpt domain; Region: Hpt; pfam01627
290512005810	putative binding surface; other site
290512005811	active site
290512005812	Uncharacterized conserved protein [Function unknown]; Region: COG3287
290512005813	FIST N domain; Region: FIST; pfam08495
290512005814	FIST C domain; Region: FIST_C; pfam10442
290512005815	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
290512005816	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_6; cd06256
290512005817	putative active site [active]
290512005818	Zn binding site [ion binding]; other site
290512005819	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290512005820	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
290512005821	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
290512005822	putative deacylase active site [active]
290512005823	CARDB; Region: CARDB; pfam07705
290512005824	CARDB; Region: CARDB; pfam07705
290512005825	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
290512005826	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
290512005827	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
290512005828	nucleophile elbow; other site
290512005829	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
290512005830	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
290512005831	NAD(P) binding site [chemical binding]; other site
290512005832	catalytic residues [active]
290512005833	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
290512005834	AAA domain; Region: AAA_32; pfam13654
290512005835	PhoH-like protein; Region: PhoH; cl17668
290512005836	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
290512005837	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290512005838	Ligand Binding Site [chemical binding]; other site
290512005839	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
290512005840	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
290512005841	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
290512005842	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
290512005843	Peptidase family U32; Region: Peptidase_U32; pfam01136
290512005844	sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910
290512005845	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
290512005846	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
290512005847	FAD binding pocket [chemical binding]; other site
290512005848	FAD binding motif [chemical binding]; other site
290512005849	phosphate binding motif [ion binding]; other site
290512005850	beta-alpha-beta structure motif; other site
290512005851	NAD binding pocket [chemical binding]; other site
290512005852	Iron coordination center [ion binding]; other site
290512005853	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
290512005854	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
290512005855	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
290512005856	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
290512005857	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
290512005858	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
290512005859	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
290512005860	Mechanosensitive ion channel; Region: MS_channel; pfam00924
290512005861	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
290512005862	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
290512005863	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
290512005864	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
290512005865	trimer interface [polypeptide binding]; other site
290512005866	putative metal binding site [ion binding]; other site
290512005867	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
290512005868	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
290512005869	Walker A/P-loop; other site
290512005870	ATP binding site [chemical binding]; other site
290512005871	Q-loop/lid; other site
290512005872	ABC transporter signature motif; other site
290512005873	Walker B; other site
290512005874	D-loop; other site
290512005875	H-loop/switch region; other site
290512005876	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
290512005877	B12 binding site [chemical binding]; other site
290512005878	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
290512005879	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512005880	FeS/SAM binding site; other site
290512005881	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
290512005882	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
290512005883	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
290512005884	Zn2+ binding site [ion binding]; other site
290512005885	Mg2+ binding site [ion binding]; other site
290512005886	YtxH-like protein; Region: YtxH; pfam12732
290512005887	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
290512005888	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
290512005889	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
290512005890	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
290512005891	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
290512005892	hinge; other site
290512005893	active site
290512005894	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
290512005895	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
290512005896	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
290512005897	dimer interface [polypeptide binding]; other site
290512005898	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290512005899	catalytic residue [active]
290512005900	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
290512005901	alanine racemase; Reviewed; Region: alr; PRK00053
290512005902	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
290512005903	active site
290512005904	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
290512005905	dimer interface [polypeptide binding]; other site
290512005906	substrate binding site [chemical binding]; other site
290512005907	catalytic residues [active]
290512005908	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
290512005909	Protein of unknown function (DUF3822); Region: DUF3822; pfam12864
290512005910	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
290512005911	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
290512005912	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
290512005913	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
290512005914	FMN binding site [chemical binding]; other site
290512005915	active site
290512005916	catalytic residues [active]
290512005917	substrate binding site [chemical binding]; other site
290512005918	recombinase A; Provisional; Region: recA; PRK09354
290512005919	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
290512005920	hexamer interface [polypeptide binding]; other site
290512005921	Walker A motif; other site
290512005922	ATP binding site [chemical binding]; other site
290512005923	Walker B motif; other site
290512005924	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
290512005925	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
290512005926	putative NADP binding site [chemical binding]; other site
290512005927	putative substrate binding site [chemical binding]; other site
290512005928	active site
290512005929	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
290512005930	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
290512005931	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
290512005932	trigger factor; Region: tig; TIGR00115
290512005933	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
290512005934	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
290512005935	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
290512005936	dimerization interface [polypeptide binding]; other site
290512005937	active site
290512005938	Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539
290512005939	active site
290512005940	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
290512005941	catalytic center binding site [active]
290512005942	ATP binding site [chemical binding]; other site
290512005943	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
290512005944	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
290512005945	P loop; other site
290512005946	Nucleotide binding site [chemical binding]; other site
290512005947	DTAP/Switch II; other site
290512005948	Switch I; other site
290512005949	Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043
290512005950	Chlorosome envelope protein C; Region: Chlorosome_CsmC; pfam11098
290512005951	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
290512005952	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
290512005953	P loop; other site
290512005954	Nucleotide binding site [chemical binding]; other site
290512005955	DTAP/Switch II; other site
290512005956	Switch I; other site
290512005957	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
290512005958	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
290512005959	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
290512005960	FAD binding pocket [chemical binding]; other site
290512005961	FAD binding motif [chemical binding]; other site
290512005962	phosphate binding motif [ion binding]; other site
290512005963	beta-alpha-beta structure motif; other site
290512005964	NAD binding pocket [chemical binding]; other site
290512005965	Iron coordination center [ion binding]; other site
290512005966	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
290512005967	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
290512005968	dimer interface [polypeptide binding]; other site
290512005969	ssDNA binding site [nucleotide binding]; other site
290512005970	tetramer (dimer of dimers) interface [polypeptide binding]; other site
290512005971	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
290512005972	DNA polymerase III, delta subunit; Region: holA; TIGR01128
290512005973	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
290512005974	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290512005975	NAD(P) binding site [chemical binding]; other site
290512005976	active site
290512005977	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
290512005978	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
290512005979	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
290512005980	catalytic residue [active]
290512005981	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
290512005982	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
290512005983	N-terminal plug; other site
290512005984	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
290512005985	ligand-binding site [chemical binding]; other site
290512005986	magnesium chelatase, H subunit; Region: BchH; TIGR02025
290512005987	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
290512005988	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
290512005989	rod shape-determining protein MreB; Provisional; Region: PRK13930
290512005990	MreB and similar proteins; Region: MreB_like; cd10225
290512005991	nucleotide binding site [chemical binding]; other site
290512005992	Mg binding site [ion binding]; other site
290512005993	putative protofilament interaction site [polypeptide binding]; other site
290512005994	RodZ interaction site [polypeptide binding]; other site
290512005995	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
290512005996	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185
290512005997	Autotransporter beta-domain; Region: Autotransporter; smart00869
290512005998	magnesium chelatase subunit H; Provisional; Region: PRK12493
290512005999	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
290512006000	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
290512006001	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
290512006002	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290512006003	S-adenosylmethionine binding site [chemical binding]; other site
290512006004	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
290512006005	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
290512006006	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
290512006007	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512006008	FeS/SAM binding site; other site
290512006009	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
290512006010	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
290512006011	putative dimer interface [polypeptide binding]; other site
290512006012	Predicted membrane protein [Function unknown]; Region: COG3174
290512006013	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
290512006014	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
290512006015	Peptidase family M23; Region: Peptidase_M23; pfam01551
290512006016	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
290512006017	hypothetical protein; Provisional; Region: PRK09256
290512006018	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
290512006019	Uncharacterized conserved protein (DUF2276); Region: DUF2276; pfam10040
290512006020	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
290512006021	CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436
290512006022	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
290512006023	CRISPR-associated protein, Csx11 family; Region: cas_csx11; TIGR02682
290512006024	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09701
290512006025	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440
290512006026	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
290512006027	FOG: WD40 repeat [General function prediction only]; Region: COG2319
290512006028	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
290512006029	structural tetrad; other site
290512006030	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
290512006031	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
290512006032	DXD motif; other site
290512006033	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
290512006034	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
290512006035	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
290512006036	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
290512006037	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
290512006038	putative active site [active]
290512006039	putative metal binding site [ion binding]; other site
290512006040	bacteriochlorophyll c synthase; Provisional; Region: PRK12392
290512006041	UbiA prenyltransferase family; Region: UbiA; pfam01040
290512006042	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14340
290512006043	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
290512006044	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512006045	FeS/SAM binding site; other site
290512006046	TRAM domain; Region: TRAM; cl01282
290512006047	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
290512006048	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
290512006049	trimerization site [polypeptide binding]; other site
290512006050	active site
290512006051	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
290512006052	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
290512006053	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
290512006054	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
290512006055	catalytic residue [active]
290512006056	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
290512006057	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
290512006058	dimer interface [polypeptide binding]; other site
290512006059	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290512006060	catalytic residue [active]
290512006061	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290512006062	non-specific DNA binding site [nucleotide binding]; other site
290512006063	salt bridge; other site
290512006064	sequence-specific DNA binding site [nucleotide binding]; other site
290512006065	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
290512006066	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
290512006067	Domain of unknown function DUF21; Region: DUF21; pfam01595
290512006068	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
290512006069	Transporter associated domain; Region: CorC_HlyC; smart01091
290512006070	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
290512006071	active site
290512006072	multimer interface [polypeptide binding]; other site
290512006073	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
290512006074	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
290512006075	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
290512006076	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
290512006077	RNA methyltransferase, RsmE family; Region: TIGR00046
290512006078	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
290512006079	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
290512006080	active site
290512006081	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
290512006082	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
290512006083	nucleotide binding site [chemical binding]; other site
290512006084	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
290512006085	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
290512006086	active site
290512006087	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
290512006088	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
290512006089	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512006090	FeS/SAM binding site; other site
290512006091	HemN C-terminal domain; Region: HemN_C; pfam06969
290512006092	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
290512006093	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290512006094	active site
290512006095	motif I; other site
290512006096	motif II; other site
290512006097	glycogen synthase; Provisional; Region: PRK14098
290512006098	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
290512006099	ADP-binding pocket [chemical binding]; other site
290512006100	homodimer interface [polypeptide binding]; other site
290512006101	Bacterial Ig-like domain; Region: Big_5; pfam13205
290512006102	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
290512006103	V4R domain; Region: V4R; cl15268
290512006104	TIR domain; Region: TIR_2; pfam13676
290512006105	Pathogenicity locus; Region: Cdd1; pfam11731
290512006106	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
290512006107	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290512006108	motif II; other site
290512006109	protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
290512006110	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
290512006111	P-loop; other site
290512006112	light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910
290512006113	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
290512006114	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
290512006115	light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842
290512006116	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
290512006117	Domain of unknown function DUF77; Region: DUF77; pfam01910
290512006118	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
290512006119	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
290512006120	GDP-binding site [chemical binding]; other site
290512006121	ACT binding site; other site
290512006122	IMP binding site; other site
290512006123	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
290512006124	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
290512006125	G1 box; other site
290512006126	GTP/Mg2+ binding site [chemical binding]; other site
290512006127	Switch I region; other site
290512006128	G2 box; other site
290512006129	G3 box; other site
290512006130	Switch II region; other site
290512006131	G4 box; other site
290512006132	G5 box; other site
290512006133	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
290512006134	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
290512006135	active site
290512006136	HIGH motif; other site
290512006137	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
290512006138	KMSKS motif; other site
290512006139	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
290512006140	tRNA binding surface [nucleotide binding]; other site
290512006141	anticodon binding site; other site
290512006142	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
290512006143	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
290512006144	Substrate binding site; other site
290512006145	Cupin domain; Region: Cupin_2; cl17218
290512006146	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
290512006147	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
290512006148	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
290512006149	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
290512006150	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
290512006151	alphaNTD homodimer interface [polypeptide binding]; other site
290512006152	alphaNTD - beta interaction site [polypeptide binding]; other site
290512006153	alphaNTD - beta' interaction site [polypeptide binding]; other site
290512006154	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
290512006155	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
290512006156	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
290512006157	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
290512006158	RNA binding surface [nucleotide binding]; other site
290512006159	30S ribosomal protein S11; Validated; Region: PRK05309
290512006160	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
290512006161	30S ribosomal protein S13; Region: bact_S13; TIGR03631
290512006162	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
290512006163	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
290512006164	rRNA binding site [nucleotide binding]; other site
290512006165	predicted 30S ribosome binding site; other site
290512006166	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
290512006167	active site
290512006168	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
290512006169	SecY translocase; Region: SecY; pfam00344
290512006170	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
290512006171	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
290512006172	23S rRNA binding site [nucleotide binding]; other site
290512006173	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
290512006174	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
290512006175	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
290512006176	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
290512006177	5S rRNA interface [nucleotide binding]; other site
290512006178	L27 interface [polypeptide binding]; other site
290512006179	23S rRNA interface [nucleotide binding]; other site
290512006180	L5 interface [polypeptide binding]; other site
290512006181	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
290512006182	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
290512006183	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
290512006184	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
290512006185	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
290512006186	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
290512006187	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
290512006188	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
290512006189	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
290512006190	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
290512006191	RNA binding site [nucleotide binding]; other site
290512006192	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
290512006193	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
290512006194	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
290512006195	putative translocon interaction site; other site
290512006196	23S rRNA interface [nucleotide binding]; other site
290512006197	signal recognition particle (SRP54) interaction site; other site
290512006198	L23 interface [polypeptide binding]; other site
290512006199	trigger factor interaction site; other site
290512006200	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
290512006201	23S rRNA interface [nucleotide binding]; other site
290512006202	5S rRNA interface [nucleotide binding]; other site
290512006203	putative antibiotic binding site [chemical binding]; other site
290512006204	L25 interface [polypeptide binding]; other site
290512006205	L27 interface [polypeptide binding]; other site
290512006206	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
290512006207	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
290512006208	G-X-X-G motif; other site
290512006209	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
290512006210	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
290512006211	putative translocon binding site; other site
290512006212	protein-rRNA interface [nucleotide binding]; other site
290512006213	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
290512006214	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
290512006215	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
290512006216	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
290512006217	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
290512006218	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
290512006219	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
290512006220	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
290512006221	elongation factor Tu; Reviewed; Region: PRK00049
290512006222	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
290512006223	G1 box; other site
290512006224	GEF interaction site [polypeptide binding]; other site
290512006225	GTP/Mg2+ binding site [chemical binding]; other site
290512006226	Switch I region; other site
290512006227	G2 box; other site
290512006228	G3 box; other site
290512006229	Switch II region; other site
290512006230	G4 box; other site
290512006231	G5 box; other site
290512006232	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
290512006233	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
290512006234	Antibiotic Binding Site [chemical binding]; other site
290512006235	elongation factor G; Reviewed; Region: PRK00007
290512006236	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
290512006237	G1 box; other site
290512006238	putative GEF interaction site [polypeptide binding]; other site
290512006239	GTP/Mg2+ binding site [chemical binding]; other site
290512006240	Switch I region; other site
290512006241	G2 box; other site
290512006242	G3 box; other site
290512006243	Switch II region; other site
290512006244	G4 box; other site
290512006245	G5 box; other site
290512006246	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
290512006247	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
290512006248	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
290512006249	30S ribosomal protein S7; Validated; Region: PRK05302
290512006250	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
290512006251	S17 interaction site [polypeptide binding]; other site
290512006252	S8 interaction site; other site
290512006253	16S rRNA interaction site [nucleotide binding]; other site
290512006254	streptomycin interaction site [chemical binding]; other site
290512006255	23S rRNA interaction site [nucleotide binding]; other site
290512006256	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
290512006257	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290512006258	Predicted membrane protein [Function unknown]; Region: COG4485
290512006259	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
290512006260	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
290512006261	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
290512006262	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
290512006263	Probable Catalytic site; other site
290512006264	metal-binding site
290512006265	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
290512006266	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290512006267	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
290512006268	dimerization domain swap beta strand [polypeptide binding]; other site
290512006269	regulatory protein interface [polypeptide binding]; other site
290512006270	active site
290512006271	regulatory phosphorylation site [posttranslational modification]; other site
290512006272	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
290512006273	Coenzyme A binding pocket [chemical binding]; other site
290512006274	GTPase CgtA; Reviewed; Region: obgE; PRK12299
290512006275	GTP1/OBG; Region: GTP1_OBG; pfam01018
290512006276	Obg GTPase; Region: Obg; cd01898
290512006277	G1 box; other site
290512006278	GTP/Mg2+ binding site [chemical binding]; other site
290512006279	Switch I region; other site
290512006280	G2 box; other site
290512006281	G3 box; other site
290512006282	Switch II region; other site
290512006283	G4 box; other site
290512006284	G5 box; other site
290512006285	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
290512006286	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
290512006287	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
290512006288	GatB domain; Region: GatB_Yqey; smart00845
290512006289	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
290512006290	putative amphipathic alpha helix; other site
290512006291	Clp amino terminal domain; Region: Clp_N; pfam02861
290512006292	Clp amino terminal domain; Region: Clp_N; pfam02861
290512006293	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290512006294	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
290512006295	Walker A motif; other site
290512006296	ATP binding site [chemical binding]; other site
290512006297	Walker B motif; other site
290512006298	arginine finger; other site
290512006299	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
290512006300	iron-sulfur cluster [ion binding]; other site
290512006301	[2Fe-2S] cluster binding site [ion binding]; other site
290512006302	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
290512006303	active site
290512006304	FMN binding site [chemical binding]; other site
290512006305	substrate binding site [chemical binding]; other site
290512006306	3Fe-4S cluster binding site [ion binding]; other site
290512006307	von Willebrand factor type A domain; Region: VWA_2; pfam13519
290512006308	metal ion-dependent adhesion site (MIDAS); other site
290512006309	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
290512006310	metal ion-dependent adhesion site (MIDAS); other site
290512006311	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
290512006312	Protein of unknown function DUF58; Region: DUF58; pfam01882
290512006313	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
290512006314	metal ion-dependent adhesion site (MIDAS); other site
290512006315	MoxR-like ATPases [General function prediction only]; Region: COG0714
290512006316	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290512006317	Walker A motif; other site
290512006318	ATP binding site [chemical binding]; other site
290512006319	Walker B motif; other site
290512006320	arginine finger; other site
290512006321	UGMP family protein; Validated; Region: PRK09604
290512006322	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
290512006323	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
290512006324	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
290512006325	Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710
290512006326	Fic family protein [Function unknown]; Region: COG3177
290512006327	Fic/DOC family; Region: Fic; pfam02661
290512006328	putative transposase OrfB; Reviewed; Region: PHA02517
290512006329	Homeodomain-like domain; Region: HTH_32; pfam13565
290512006330	Integrase core domain; Region: rve; pfam00665
290512006331	Integrase core domain; Region: rve_3; pfam13683
290512006332	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
290512006333	Protein of unknown function (DUF1045); Region: DUF1045; cl15435
290512006334	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512006335	Radical SAM superfamily; Region: Radical_SAM; pfam04055
290512006336	FeS/SAM binding site; other site
290512006337	Integrase core domain; Region: rve; pfam00665
290512006338	Integrase core domain; Region: rve_3; pfam13683
290512006339	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
290512006340	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
290512006341	putative active site [active]
290512006342	putative NTP binding site [chemical binding]; other site
290512006343	putative nucleic acid binding site [nucleotide binding]; other site
290512006344	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
290512006345	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
290512006346	Transposase; Region: HTH_Tnp_1; pfam01527
290512006347	Domain of unknown function DUF87; Region: DUF87; pfam01935
290512006348	HerA helicase [Replication, recombination, and repair]; Region: COG0433
290512006349	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
290512006350	ligand binding site [chemical binding]; other site
290512006351	active site
290512006352	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
290512006353	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
290512006354	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
290512006355	active site
290512006356	Preprotein translocase subunit; Region: YajC; pfam02699
290512006357	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
290512006358	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
290512006359	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
290512006360	catalytic site [active]
290512006361	subunit interface [polypeptide binding]; other site
290512006362	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
290512006363	B12 binding site [chemical binding]; other site
290512006364	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
290512006365	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512006366	FeS/SAM binding site; other site
290512006367	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
290512006368	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
290512006369	Uncharacterized conserved protein [Function unknown]; Region: COG4095
290512006370	pyrroline-5-carboxylate reductase; Region: PLN02688
290512006371	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
290512006372	Oxygen tolerance; Region: BatD; pfam13584
290512006373	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
290512006374	MoaE homodimer interface [polypeptide binding]; other site
290512006375	MoaD interaction [polypeptide binding]; other site
290512006376	active site residues [active]
290512006377	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
290512006378	MoaE interaction surface [polypeptide binding]; other site
290512006379	MoeB interaction surface [polypeptide binding]; other site
290512006380	thiocarboxylated glycine; other site
290512006381	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
290512006382	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
290512006383	dimer interface [polypeptide binding]; other site
290512006384	putative functional site; other site
290512006385	putative MPT binding site; other site
290512006386	bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604
290512006387	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
290512006388	trimer interface [polypeptide binding]; other site
290512006389	dimer interface [polypeptide binding]; other site
290512006390	putative active site [active]
290512006391	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
290512006392	MPT binding site; other site
290512006393	trimer interface [polypeptide binding]; other site
290512006394	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
290512006395	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512006396	FeS/SAM binding site; other site
290512006397	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
290512006398	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
290512006399	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
290512006400	active site
290512006401	catalytic site [active]
290512006402	putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; Provisional; Region: PRK14490
290512006403	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
290512006404	Walker A motif; other site
290512006405	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
290512006406	GTP binding site; other site
290512006407	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290512006408	Ligand Binding Site [chemical binding]; other site
290512006409	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
290512006410	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
290512006411	catalytic loop [active]
290512006412	iron binding site [ion binding]; other site
290512006413	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
290512006414	FAD binding pocket [chemical binding]; other site
290512006415	FAD binding motif [chemical binding]; other site
290512006416	phosphate binding motif [ion binding]; other site
290512006417	beta-alpha-beta structure motif; other site
290512006418	NAD binding pocket [chemical binding]; other site
290512006419	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
290512006420	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
290512006421	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
290512006422	FMN-binding domain; Region: FMN_bind; cl01081
290512006423	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
290512006424	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
290512006425	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
290512006426	thiosulfate reductase PhsA; Provisional; Region: PRK15488
290512006427	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
290512006428	putative [Fe4-S4] binding site [ion binding]; other site
290512006429	putative molybdopterin cofactor binding site [chemical binding]; other site
290512006430	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
290512006431	molybdopterin cofactor binding site; other site
290512006432	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
290512006433	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
290512006434	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290512006435	NAD(P) binding site [chemical binding]; other site
290512006436	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
290512006437	active site
290512006438	Restriction endonuclease; Region: Mrr_cat; pfam04471
290512006439	Protein of unknown function (DUF3732); Region: DUF3732; pfam12532
290512006440	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
290512006441	TIR domain; Region: TIR_2; pfam13676
290512006442	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
290512006443	Transposase; Region: DEDD_Tnp_IS110; pfam01548
290512006444	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
290512006445	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
290512006446	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
290512006447	catalytic triad [active]
290512006448	SOUL heme-binding protein; Region: SOUL; pfam04832
290512006449	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
290512006450	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
290512006451	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
290512006452	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
290512006453	octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315
290512006454	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
290512006455	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
290512006456	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
290512006457	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
290512006458	active site
290512006459	prephenate dehydrogenase; Validated; Region: PRK08507
290512006460	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
290512006461	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
290512006462	ATP-NAD kinase; Region: NAD_kinase; pfam01513
290512006463	TPR repeat; Region: TPR_11; pfam13414
290512006464	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512006465	TPR motif; other site
290512006466	TPR repeat; Region: TPR_11; pfam13414
290512006467	binding surface
290512006468	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
290512006469	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
290512006470	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
290512006471	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290512006472	Walker A motif; other site
290512006473	ATP binding site [chemical binding]; other site
290512006474	Walker B motif; other site
290512006475	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
290512006476	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
290512006477	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
290512006478	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
290512006479	catalytic core [active]
290512006480	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
290512006481	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
290512006482	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
290512006483	membrane protein; Provisional; Region: PRK14410
290512006484	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
290512006485	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
290512006486	dimerization interface [polypeptide binding]; other site
290512006487	putative ATP binding site [chemical binding]; other site
290512006488	aspartate kinase III; Validated; Region: PRK09084
290512006489	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
290512006490	nucleotide binding site [chemical binding]; other site
290512006491	substrate binding site [chemical binding]; other site
290512006492	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
290512006493	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
290512006494	NlpC/P60 family; Region: NLPC_P60; pfam00877
290512006495	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
290512006496	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290512006497	S-adenosylmethionine binding site [chemical binding]; other site
290512006498	exopolyphosphatase; Region: exo_poly_only; TIGR03706
290512006499	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
290512006500	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603
290512006501	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290512006502	S-adenosylmethionine binding site [chemical binding]; other site
290512006503	Jacalin-like lectin domain; Region: Jacalin_like; cd09302
290512006504	putative sugar binding site [chemical binding]; other site
290512006505	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
290512006506	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
290512006507	active site
290512006508	ATP-binding site [chemical binding]; other site
290512006509	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
290512006510	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
290512006511	inhibitor-cofactor binding pocket; inhibition site
290512006512	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290512006513	catalytic residue [active]
290512006514	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
290512006515	AAA domain; Region: AAA_26; pfam13500
290512006516	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
290512006517	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290512006518	S-adenosylmethionine binding site [chemical binding]; other site
290512006519	Protein of unknown function (DUF452); Region: DUF452; cl01062
290512006520	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
290512006521	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
290512006522	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
290512006523	catalytic residue [active]
290512006524	biotin synthase; Region: bioB; TIGR00433
290512006525	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512006526	FeS/SAM binding site; other site
290512006527	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
290512006528	Biotin operon repressor [Transcription]; Region: BirA; COG1654
290512006529	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
290512006530	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
290512006531	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
290512006532	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290512006533	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
290512006534	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290512006535	ATP binding site [chemical binding]; other site
290512006536	Mg2+ binding site [ion binding]; other site
290512006537	G-X-G motif; other site
290512006538	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
290512006539	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290512006540	active site
290512006541	phosphorylation site [posttranslational modification]
290512006542	intermolecular recognition site; other site
290512006543	dimerization interface [polypeptide binding]; other site
290512006544	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
290512006545	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290512006546	active site
290512006547	phosphorylation site [posttranslational modification]
290512006548	intermolecular recognition site; other site
290512006549	dimerization interface [polypeptide binding]; other site
290512006550	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290512006551	S-adenosylmethionine binding site [chemical binding]; other site
290512006552	peroxiredoxin; Provisional; Region: PRK13189
290512006553	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
290512006554	dimer interface [polypeptide binding]; other site
290512006555	decamer (pentamer of dimers) interface [polypeptide binding]; other site
290512006556	catalytic triad [active]
290512006557	DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052
290512006558	Ferritin-like domain; Region: Ferritin; pfam00210
290512006559	diiron binding motif [ion binding]; other site
290512006560	Rubrerythrin [Energy production and conversion]; Region: COG1592
290512006561	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
290512006562	binuclear metal center [ion binding]; other site
290512006563	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
290512006564	iron binding site [ion binding]; other site
290512006565	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
290512006566	metal binding site 2 [ion binding]; metal-binding site
290512006567	putative DNA binding helix; other site
290512006568	metal binding site 1 [ion binding]; metal-binding site
290512006569	dimer interface [polypeptide binding]; other site
290512006570	structural Zn2+ binding site [ion binding]; other site
290512006571	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
290512006572	Transposase; Region: DEDD_Tnp_IS110; pfam01548
290512006573	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
290512006574	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
290512006575	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
290512006576	active site
290512006577	DNA binding site [nucleotide binding]
290512006578	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
290512006579	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
290512006580	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
290512006581	Catalytic site [active]
290512006582	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
290512006583	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
290512006584	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
290512006585	HlyD family secretion protein; Region: HlyD_3; pfam13437
290512006586	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
290512006587	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
290512006588	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
290512006589	Walker A/P-loop; other site
290512006590	ATP binding site [chemical binding]; other site
290512006591	Q-loop/lid; other site
290512006592	ABC transporter signature motif; other site
290512006593	Walker B; other site
290512006594	D-loop; other site
290512006595	H-loop/switch region; other site
290512006596	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
290512006597	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
290512006598	Walker A/P-loop; other site
290512006599	ATP binding site [chemical binding]; other site
290512006600	Q-loop/lid; other site
290512006601	ABC transporter signature motif; other site
290512006602	Walker B; other site
290512006603	D-loop; other site
290512006604	H-loop/switch region; other site
290512006605	Uncharacterized conserved protein [Function unknown]; Region: COG3391
290512006606	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
290512006607	active site
290512006608	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
290512006609	active site
290512006610	Bacterial Ig-like domain; Region: Big_5; pfam13205
290512006611	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
290512006612	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
290512006613	active site
290512006614	metal binding site [ion binding]; metal-binding site
290512006615	DNA topoisomerase I; Validated; Region: PRK06599
290512006616	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
290512006617	active site
290512006618	interdomain interaction site; other site
290512006619	putative metal-binding site [ion binding]; other site
290512006620	nucleotide binding site [chemical binding]; other site
290512006621	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
290512006622	domain I; other site
290512006623	DNA binding groove [nucleotide binding]
290512006624	phosphate binding site [ion binding]; other site
290512006625	domain II; other site
290512006626	domain III; other site
290512006627	nucleotide binding site [chemical binding]; other site
290512006628	catalytic site [active]
290512006629	domain IV; other site
290512006630	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
290512006631	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
290512006632	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
290512006633	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
290512006634	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
290512006635	G1 box; other site
290512006636	GTP/Mg2+ binding site [chemical binding]; other site
290512006637	Switch I region; other site
290512006638	G2 box; other site
290512006639	G3 box; other site
290512006640	Switch II region; other site
290512006641	G4 box; other site
290512006642	G5 box; other site
290512006643	Nucleoside recognition; Region: Gate; pfam07670
290512006644	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
290512006645	Nucleoside recognition; Region: Gate; pfam07670
290512006646	FeoA domain; Region: FeoA; pfam04023
290512006647	aconitate hydratase; Validated; Region: PRK09277
290512006648	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
290512006649	substrate binding site [chemical binding]; other site
290512006650	ligand binding site [chemical binding]; other site
290512006651	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
290512006652	substrate binding site [chemical binding]; other site
290512006653	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
290512006654	nucleotide binding site/active site [active]
290512006655	HIT family signature motif; other site
290512006656	catalytic residue [active]
290512006657	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
290512006658	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
290512006659	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
290512006660	phosphate binding site [ion binding]; other site
290512006661	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
290512006662	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
290512006663	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
290512006664	active site
290512006665	dimer interface [polypeptide binding]; other site
290512006666	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
290512006667	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
290512006668	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
290512006669	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
290512006670	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
290512006671	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
290512006672	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
290512006673	DNA binding site [nucleotide binding]
290512006674	active site
290512006675	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
290512006676	active site
290512006677	intersubunit interactions; other site
290512006678	catalytic residue [active]
290512006679	Domain of unknown function (DUF4071); Region: DUF4071; pfam13281
290512006680	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
290512006681	TIR domain; Region: TIR_2; pfam13676
290512006682	gliding motility-associated lipoprotein GldK; Region: GldK_short; TIGR03529
290512006683	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
290512006684	deoxyhypusine synthase-like protein; Provisional; Region: PRK02492
290512006685	deoxyhypusine synthase; Region: dhys; TIGR00321
290512006686	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
290512006687	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
290512006688	active site
290512006689	HIGH motif; other site
290512006690	dimer interface [polypeptide binding]; other site
290512006691	KMSKS motif; other site
290512006692	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
290512006693	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290512006694	motif II; other site
290512006695	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
290512006696	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
290512006697	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
290512006698	active site
290512006699	HIGH motif; other site
290512006700	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
290512006701	KMSK motif region; other site
290512006702	tRNA binding surface [nucleotide binding]; other site
290512006703	DALR anticodon binding domain; Region: DALR_1; smart00836
290512006704	anticodon binding site; other site
290512006705	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
290512006706	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
290512006707	active site
290512006708	(T/H)XGH motif; other site
290512006709	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
290512006710	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
290512006711	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
290512006712	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
290512006713	F0F1 ATP synthase subunit B; Provisional; Region: PRK14472
290512006714	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
290512006715	ATP synthase subunit C; Region: ATP-synt_C; cl00466
290512006716	F0F1 ATP synthase subunit A; Provisional; Region: PRK13419
290512006717	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
290512006718	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
290512006719	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
290512006720	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
290512006721	NAD binding site [chemical binding]; other site
290512006722	homodimer interface [polypeptide binding]; other site
290512006723	active site
290512006724	substrate binding site [chemical binding]; other site
290512006725	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
290512006726	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
290512006727	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
290512006728	O-methyltransferase; Region: Methyltransf_2; pfam00891
290512006729	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
290512006730	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
290512006731	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
290512006732	L-aspartate oxidase; Provisional; Region: PRK06175
290512006733	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
290512006734	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
290512006735	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
290512006736	putative Iron-sulfur protein interface [polypeptide binding]; other site
290512006737	putative proximal heme binding site [chemical binding]; other site
290512006738	putative SdhC-like subunit interface [polypeptide binding]; other site
290512006739	putative distal heme binding site [chemical binding]; other site
290512006740	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
290512006741	putative Iron-sulfur protein interface [polypeptide binding]; other site
290512006742	putative proximal heme binding site [chemical binding]; other site
290512006743	putative SdhD-like interface [polypeptide binding]; other site
290512006744	putative distal heme binding site [chemical binding]; other site
290512006745	cell division protein FtsZ; Validated; Region: PRK09330
290512006746	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
290512006747	nucleotide binding site [chemical binding]; other site
290512006748	SulA interaction site; other site
290512006749	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
290512006750	Cell division protein FtsA; Region: FtsA; smart00842
290512006751	Cell division protein FtsA; Region: FtsA; pfam14450
290512006752	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
290512006753	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
290512006754	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
290512006755	FAD binding domain; Region: FAD_binding_4; pfam01565
290512006756	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
290512006757	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
290512006758	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
290512006759	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
290512006760	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
290512006761	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
290512006762	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
290512006763	active site
290512006764	homodimer interface [polypeptide binding]; other site
290512006765	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
290512006766	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
290512006767	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
290512006768	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
290512006769	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
290512006770	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
290512006771	Mg++ binding site [ion binding]; other site
290512006772	putative catalytic motif [active]
290512006773	putative substrate binding site [chemical binding]; other site
290512006774	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
290512006775	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
290512006776	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
290512006777	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
290512006778	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
290512006779	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
290512006780	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
290512006781	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
290512006782	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
290512006783	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
290512006784	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
290512006785	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
290512006786	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
290512006787	MraW methylase family; Region: Methyltransf_5; cl17771
290512006788	cell division protein MraZ; Reviewed; Region: PRK00326
290512006789	MraZ protein; Region: MraZ; pfam02381
290512006790	MraZ protein; Region: MraZ; pfam02381
290512006791	YacP-like NYN domain; Region: NYN_YacP; pfam05991
290512006792	Chorismate mutase type II; Region: CM_2; pfam01817
290512006793	YceG-like family; Region: YceG; pfam02618
290512006794	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
290512006795	dimerization interface [polypeptide binding]; other site
290512006796	Phosphoglycerate kinase; Region: PGK; pfam00162
290512006797	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
290512006798	substrate binding site [chemical binding]; other site
290512006799	hinge regions; other site
290512006800	ADP binding site [chemical binding]; other site
290512006801	catalytic site [active]
290512006802	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
290512006803	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
290512006804	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
290512006805	dimer interface [polypeptide binding]; other site
290512006806	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
290512006807	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
290512006808	active site
290512006809	catalytic residues [active]
290512006810	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
290512006811	active site
290512006812	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512006813	binding surface
290512006814	TPR motif; other site
290512006815	TPR repeat; Region: TPR_11; pfam13414
290512006816	Tetratricopeptide repeat; Region: TPR_16; pfam13432
290512006817	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512006818	TPR motif; other site
290512006819	binding surface
290512006820	TPR repeat; Region: TPR_11; pfam13414
290512006821	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512006822	binding surface
290512006823	TPR motif; other site
290512006824	TPR repeat; Region: TPR_11; pfam13414
290512006825	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512006826	binding surface
290512006827	TPR motif; other site
290512006828	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
290512006829	B12 binding site [chemical binding]; other site
290512006830	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
290512006831	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512006832	FeS/SAM binding site; other site
290512006833	radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334
290512006834	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512006835	FeS/SAM binding site; other site
290512006836	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
290512006837	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
290512006838	active site
290512006839	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
290512006840	catalytic tetrad [active]
290512006841	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
290512006842	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
290512006843	N-terminal plug; other site
290512006844	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
290512006845	ligand-binding site [chemical binding]; other site
290512006846	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
290512006847	metal binding site 2 [ion binding]; metal-binding site
290512006848	putative DNA binding helix; other site
290512006849	metal binding site 1 [ion binding]; metal-binding site
290512006850	dimer interface [polypeptide binding]; other site
290512006851	structural Zn2+ binding site [ion binding]; other site
290512006852	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290512006853	PAS fold; Region: PAS_3; pfam08447
290512006854	putative active site [active]
290512006855	heme pocket [chemical binding]; other site
290512006856	PAS domain; Region: PAS_8; pfam13188
290512006857	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
290512006858	Transposase; Region: DEDD_Tnp_IS110; pfam01548
290512006859	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
290512006860	Fic family protein [Function unknown]; Region: COG3177
290512006861	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
290512006862	Fic/DOC family; Region: Fic; pfam02661
290512006863	TIR domain; Region: TIR_2; pfam13676
290512006864	FOG: WD40 repeat [General function prediction only]; Region: COG2319
290512006865	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
290512006866	structural tetrad; other site
290512006867	FOG: WD40 repeat [General function prediction only]; Region: COG2319
290512006868	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
290512006869	structural tetrad; other site
290512006870	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
290512006871	Fic family protein [Function unknown]; Region: COG3177
290512006872	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
290512006873	DNA-binding interface [nucleotide binding]; DNA binding site
290512006874	putative transposase OrfB; Reviewed; Region: PHA02517
290512006875	HTH-like domain; Region: HTH_21; pfam13276
290512006876	Integrase core domain; Region: rve; pfam00665
290512006877	Integrase core domain; Region: rve_3; pfam13683
290512006878	Transposase; Region: HTH_Tnp_1; cl17663
290512006879	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
290512006880	DNA-binding interface [nucleotide binding]; DNA binding site
290512006881	putative transposase OrfB; Reviewed; Region: PHA02517
290512006882	HTH-like domain; Region: HTH_21; pfam13276
290512006883	Integrase core domain; Region: rve; pfam00665
290512006884	Integrase core domain; Region: rve_3; pfam13683
290512006885	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
290512006886	Part of AAA domain; Region: AAA_19; pfam13245
290512006887	Family description; Region: UvrD_C_2; pfam13538
290512006888	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
290512006889	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
290512006890	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
290512006891	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
290512006892	cofactor binding site; other site
290512006893	DNA binding site [nucleotide binding]
290512006894	substrate interaction site [chemical binding]; other site
290512006895	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
290512006896	FAD binding domain; Region: FAD_binding_4; pfam01565
290512006897	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
290512006898	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
290512006899	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
290512006900	Transposase; Region: HTH_Tnp_1; pfam01527
290512006901	HTH-like domain; Region: HTH_21; pfam13276
290512006902	Integrase core domain; Region: rve; pfam00665
290512006903	Integrase core domain; Region: rve_3; pfam13683
290512006904	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
290512006905	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290512006906	active site
290512006907	phosphorylation site [posttranslational modification]
290512006908	intermolecular recognition site; other site
290512006909	FRG domain; Region: FRG; pfam08867
290512006910	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
290512006911	FAD binding domain; Region: FAD_binding_4; pfam01565
290512006912	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
290512006913	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
290512006914	putative FMN binding site [chemical binding]; other site
290512006915	NADPH bind site [chemical binding]; other site
290512006916	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865
290512006917	putative hydrophobic ligand binding site [chemical binding]; other site
290512006918	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
290512006919	ATP-grasp domain; Region: ATP-grasp; pfam02222
290512006920	TRAM domain; Region: TRAM; cl01282
290512006921	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
290512006922	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
290512006923	fructokinase; Reviewed; Region: PRK09557
290512006924	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
290512006925	nucleotide binding site [chemical binding]; other site
290512006926	PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395
290512006927	active site
290512006928	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
290512006929	membrane protein insertase; Provisional; Region: PRK01318
290512006930	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
290512006931	Haemolytic domain; Region: Haemolytic; pfam01809
290512006932	ribonuclease P; Reviewed; Region: rnpA; PRK01903
290512006933	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
290512006934	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
290512006935	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
290512006936	P-loop; other site
290512006937	Magnesium ion binding site [ion binding]; other site
290512006938	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
290512006939	Magnesium ion binding site [ion binding]; other site
290512006940	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
290512006941	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
290512006942	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
290512006943	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
290512006944	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
290512006945	conjugal transfer coupling protein TraG; Provisional; Region: PRK13880
290512006946	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
290512006947	Walker A motif; other site
290512006948	ATP binding site [chemical binding]; other site
290512006949	Walker B motif; other site
290512006950	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
290512006951	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
290512006952	Walker A motif; other site
290512006953	ATP binding site [chemical binding]; other site
290512006954	Walker B motif; other site
290512006955	TrbC/VIRB2 family; Region: TrbC; pfam04956
290512006956	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
290512006957	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
290512006958	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
290512006959	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
290512006960	Walker A/P-loop; other site
290512006961	ATP binding site [chemical binding]; other site
290512006962	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
290512006963	conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193
290512006964	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
290512006965	VirB8 protein; Region: VirB8; cl01500
290512006966	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
290512006967	VirB7 interaction site; other site
290512006968	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
290512006969	Protein of unknown function (DUF2274); Region: DUF2274; cl02406
290512006970	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
290512006971	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
290512006972	active site
290512006973	metal binding site [ion binding]; metal-binding site
290512006974	interdomain interaction site; other site
290512006975	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
290512006976	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
290512006977	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
290512006978	H-NS histone family; Region: Histone_HNS; pfam00816
290512006979	Domain of unknown function(DUF2779); Region: DUF2779; pfam11074
290512006980	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
290512006981	Divergent AAA domain; Region: AAA_4; pfam04326
290512006982	NusA N-terminal domain; Region: NusA_N; pfam08529
290512006983	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
290512006984	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
290512006985	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
290512006986	nif11-like peptide radical SAM maturase; Region: rSAM_nif11; TIGR04064
290512006987	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290512006988	FeS/SAM binding site; other site
290512006989	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
290512006990	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
290512006991	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
290512006992	MPN+ (JAMM) motif; other site
290512006993	Zinc-binding site [ion binding]; other site
290512006994	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
290512006995	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
290512006996	active site
290512006997	DNA binding site [nucleotide binding]
290512006998	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
290512006999	AAA domain; Region: AAA_14; pfam13173
290512007000	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
290512007001	Filovirus membrane-associated protein VP24; Region: Filo_VP24; pfam06389
290512007002	TIR domain; Region: TIR_2; pfam13676
290512007003	AAA ATPase domain; Region: AAA_16; pfam13191
290512007004	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290512007005	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512007006	binding surface
290512007007	TPR motif; other site
290512007008	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290512007009	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512007010	TPR motif; other site
290512007011	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290512007012	binding surface
290512007013	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
290512007014	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
290512007015	catalytic residues [active]
290512007016	catalytic nucleophile [active]
290512007017	Presynaptic Site I dimer interface [polypeptide binding]; other site
290512007018	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
290512007019	Synaptic Flat tetramer interface [polypeptide binding]; other site
290512007020	Synaptic Site I dimer interface [polypeptide binding]; other site
290512007021	DNA binding site [nucleotide binding]
290512007022	Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796
290512007023	DNA-binding interface [nucleotide binding]; DNA binding site
290512007024	Restriction endonuclease; Region: Mrr_cat; pfam04471
290512007025	RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467
290512007026	Uncharacterized conserved protein [Function unknown]; Region: COG1262
290512007027	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
290512007028	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
290512007029	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
290512007030	putative active site [active]
290512007031	putative NTP binding site [chemical binding]; other site
290512007032	putative nucleic acid binding site [nucleotide binding]; other site
290512007033	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
290512007034	HRDC domain; Region: HRDC; pfam00570
290512007035	Uncharacterized conserved protein [Function unknown]; Region: COG1262
290512007036	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
290512007037	multiple promoter invertase; Provisional; Region: mpi; PRK13413
290512007038	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
290512007039	catalytic residues [active]
290512007040	catalytic nucleophile [active]
290512007041	Presynaptic Site I dimer interface [polypeptide binding]; other site
290512007042	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
290512007043	Synaptic Flat tetramer interface [polypeptide binding]; other site
290512007044	Synaptic Site I dimer interface [polypeptide binding]; other site
290512007045	DNA binding site [nucleotide binding]
290512007046	aconitate hydratase 2; Region: acnB; TIGR00117
290512007047	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447
290512007048	GIY-YIG motif/motif A; other site
290512007049	putative active site [active]
290512007050	putative metal binding site [ion binding]; other site
290512007051	Domain of unknown function (DUF4357); Region: DUF4357; pfam14267
290512007052	AAA domain; Region: AAA_13; pfam13166
290512007053	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
290512007054	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
290512007055	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
290512007056	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
290512007057	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
290512007058	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290512007059	ATP binding site [chemical binding]; other site
290512007060	putative Mg++ binding site [ion binding]; other site
290512007061	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512007062	TPR motif; other site
290512007063	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290512007064	binding surface
290512007065	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290512007066	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512007067	binding surface
290512007068	TPR motif; other site
290512007069	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290512007070	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290512007071	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512007072	binding surface
290512007073	TPR motif; other site
290512007074	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290512007075	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290512007076	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290512007077	binding surface
290512007078	TPR motif; other site
290512007079	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290512007080	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290512007081	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
290512007082	Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710
290512007083	Plasmid encoded RepA protein; Region: RepA_C; pfam04796