-- dump date 20140620_001355 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1266738000001 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1266738000002 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1266738000003 DNA-binding site [nucleotide binding]; DNA binding site 1266738000004 FCD domain; Region: FCD; pfam07729 1266738000005 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1266738000006 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1266738000007 putative active site [active] 1266738000008 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1266738000009 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1266738000010 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1266738000011 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1266738000012 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1266738000013 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1266738000014 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1266738000015 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1266738000016 carboxyltransferase (CT) interaction site; other site 1266738000017 biotinylation site [posttranslational modification]; other site 1266738000018 Predicted membrane protein [Function unknown]; Region: COG4125 1266738000019 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1266738000020 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1266738000021 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1266738000022 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738000023 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1266738000024 dimerization interface [polypeptide binding]; other site 1266738000025 transcriptional regulator NarL; Provisional; Region: PRK10651 1266738000026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738000027 active site 1266738000028 phosphorylation site [posttranslational modification] 1266738000029 intermolecular recognition site; other site 1266738000030 dimerization interface [polypeptide binding]; other site 1266738000031 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1266738000032 DNA binding residues [nucleotide binding] 1266738000033 dimerization interface [polypeptide binding]; other site 1266738000034 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1266738000035 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1266738000036 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1266738000037 dimerization interface [polypeptide binding]; other site 1266738000038 Histidine kinase; Region: HisKA_3; pfam07730 1266738000039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1266738000040 ATP binding site [chemical binding]; other site 1266738000041 Mg2+ binding site [ion binding]; other site 1266738000042 G-X-G motif; other site 1266738000043 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1266738000044 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1266738000045 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1266738000046 [4Fe-4S] binding site [ion binding]; other site 1266738000047 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1266738000048 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1266738000049 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1266738000050 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1266738000051 molybdopterin cofactor binding site; other site 1266738000052 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1266738000053 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1266738000054 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 1266738000055 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 1266738000056 teramer interface [polypeptide binding]; other site 1266738000057 active site 1266738000058 FMN binding site [chemical binding]; other site 1266738000059 catalytic residues [active] 1266738000060 phosphoethanolamine transferase; Provisional; Region: PRK11560 1266738000061 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1266738000062 Sulfatase; Region: Sulfatase; pfam00884 1266738000063 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1266738000064 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1266738000065 molybdopterin cofactor binding site; other site 1266738000066 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1266738000067 molybdopterin cofactor binding site; other site 1266738000068 Biofilm formation and stress response factor; Region: BsmA; cl01794 1266738000069 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1266738000070 4Fe-4S binding domain; Region: Fer4; cl02805 1266738000071 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1266738000072 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 1266738000073 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 1266738000074 multidrug efflux system protein; Provisional; Region: PRK11431 1266738000075 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1266738000076 Iron-sulfur protein interface; other site 1266738000077 proximal quinone binding site [chemical binding]; other site 1266738000078 C-subunit interface; other site 1266738000079 distal quinone binding site; other site 1266738000080 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1266738000081 D-subunit interface [polypeptide binding]; other site 1266738000082 Iron-sulfur protein interface; other site 1266738000083 proximal quinone binding site [chemical binding]; other site 1266738000084 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 1266738000085 L-aspartate oxidase; Provisional; Region: PRK06175 1266738000086 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1266738000087 poxB regulator PoxA; Provisional; Region: PRK09350 1266738000088 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1266738000089 motif 1; other site 1266738000090 dimer interface [polypeptide binding]; other site 1266738000091 active site 1266738000092 motif 2; other site 1266738000093 motif 3; other site 1266738000094 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1266738000095 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 1266738000096 active site 1266738000097 catalytic site [active] 1266738000098 metal binding site [ion binding]; metal-binding site 1266738000099 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1266738000100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738000101 putative substrate translocation pore; other site 1266738000102 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 1266738000103 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1266738000104 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1266738000105 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1266738000106 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1266738000107 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 1266738000108 Cysteine-rich domain; Region: CCG; pfam02754 1266738000109 Cysteine-rich domain; Region: CCG; pfam02754 1266738000110 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1266738000111 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1266738000112 dimer interface [polypeptide binding]; other site 1266738000113 active site 1266738000114 metal binding site [ion binding]; metal-binding site 1266738000115 hypothetical protein; Provisional; Region: PRK11212 1266738000116 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1266738000117 CPxP motif; other site 1266738000118 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1266738000119 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1266738000120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1266738000121 Probable transposase; Region: OrfB_IS605; pfam01385 1266738000122 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1266738000123 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1266738000124 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1266738000125 HlyD family secretion protein; Region: HlyD_3; pfam13437 1266738000126 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1266738000127 Protein export membrane protein; Region: SecD_SecF; cl14618 1266738000128 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1266738000129 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1266738000130 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1266738000131 metal-binding site [ion binding] 1266738000132 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1266738000133 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1266738000134 Predicted membrane protein [Function unknown]; Region: COG3714 1266738000135 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1266738000136 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1266738000137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738000138 S-adenosylmethionine binding site [chemical binding]; other site 1266738000139 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1266738000140 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1266738000141 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1266738000142 P loop; other site 1266738000143 GTP binding site [chemical binding]; other site 1266738000144 cell division protein FtsE; Provisional; Region: PRK10908 1266738000145 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738000146 Walker A/P-loop; other site 1266738000147 ATP binding site [chemical binding]; other site 1266738000148 Q-loop/lid; other site 1266738000149 ABC transporter signature motif; other site 1266738000150 Walker B; other site 1266738000151 D-loop; other site 1266738000152 H-loop/switch region; other site 1266738000153 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1266738000154 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1266738000155 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1266738000156 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1266738000157 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1266738000158 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1266738000159 DNA binding residues [nucleotide binding] 1266738000160 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1266738000161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1266738000162 Coenzyme A binding pocket [chemical binding]; other site 1266738000163 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1266738000164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738000165 putative substrate translocation pore; other site 1266738000166 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1266738000167 MarR family; Region: MarR; pfam01047 1266738000168 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1266738000169 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1266738000170 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1266738000171 Walker A/P-loop; other site 1266738000172 ATP binding site [chemical binding]; other site 1266738000173 Q-loop/lid; other site 1266738000174 ABC transporter signature motif; other site 1266738000175 Walker B; other site 1266738000176 D-loop; other site 1266738000177 H-loop/switch region; other site 1266738000178 TOBE domain; Region: TOBE_2; pfam08402 1266738000179 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1266738000180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738000181 dimer interface [polypeptide binding]; other site 1266738000182 conserved gate region; other site 1266738000183 putative PBP binding loops; other site 1266738000184 ABC-ATPase subunit interface; other site 1266738000185 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1266738000186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738000187 dimer interface [polypeptide binding]; other site 1266738000188 conserved gate region; other site 1266738000189 putative PBP binding loops; other site 1266738000190 ABC-ATPase subunit interface; other site 1266738000191 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1266738000192 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1266738000193 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1266738000194 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1266738000195 putative active site [active] 1266738000196 catalytic site [active] 1266738000197 putative metal binding site [ion binding]; other site 1266738000198 putative cyanate transporter; Provisional; Region: cynX; PRK09705 1266738000199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738000200 putative substrate translocation pore; other site 1266738000201 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1266738000202 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1266738000203 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1266738000204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1266738000205 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1266738000206 Na binding site [ion binding]; other site 1266738000207 hypothetical protein; Provisional; Region: PRK10633 1266738000208 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1266738000209 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1266738000210 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1266738000211 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1266738000212 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1266738000213 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1266738000214 carboxyltransferase (CT) interaction site; other site 1266738000215 biotinylation site [posttranslational modification]; other site 1266738000216 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1266738000217 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1266738000218 active site 1266738000219 trimer interface [polypeptide binding]; other site 1266738000220 dimer interface [polypeptide binding]; other site 1266738000221 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1266738000222 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1266738000223 NADP binding site [chemical binding]; other site 1266738000224 dimer interface [polypeptide binding]; other site 1266738000225 rod shape-determining protein MreB; Provisional; Region: PRK13927 1266738000226 MreB and similar proteins; Region: MreB_like; cd10225 1266738000227 nucleotide binding site [chemical binding]; other site 1266738000228 Mg binding site [ion binding]; other site 1266738000229 putative protofilament interaction site [polypeptide binding]; other site 1266738000230 RodZ interaction site [polypeptide binding]; other site 1266738000231 rod shape-determining protein MreC; Region: mreC; TIGR00219 1266738000232 rod shape-determining protein MreC; Region: MreC; pfam04085 1266738000233 rod shape-determining protein MreD; Provisional; Region: PRK11060 1266738000234 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1266738000235 active site 1266738000236 dimer interface [polypeptide binding]; other site 1266738000237 ribonuclease G; Provisional; Region: PRK11712 1266738000238 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1266738000239 homodimer interface [polypeptide binding]; other site 1266738000240 oligonucleotide binding site [chemical binding]; other site 1266738000241 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1266738000242 hypothetical protein; Provisional; Region: PRK10899 1266738000243 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1266738000244 nitrilase; Region: PLN02798 1266738000245 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1266738000246 putative active site [active] 1266738000247 catalytic triad [active] 1266738000248 dimer interface [polypeptide binding]; other site 1266738000249 protease TldD; Provisional; Region: tldD; PRK10735 1266738000250 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 1266738000251 active site 1266738000252 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1266738000253 RNAase interaction site [polypeptide binding]; other site 1266738000254 hypothetical protein; Provisional; Region: PRK05255 1266738000255 peptidase PmbA; Provisional; Region: PRK11040 1266738000256 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1266738000257 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1266738000258 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1266738000259 dimerization domain swap beta strand [polypeptide binding]; other site 1266738000260 regulatory protein interface [polypeptide binding]; other site 1266738000261 active site 1266738000262 regulatory phosphorylation site [posttranslational modification]; other site 1266738000263 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1266738000264 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1266738000265 active site 1266738000266 phosphorylation site [posttranslational modification] 1266738000267 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1266738000268 30S subunit binding site; other site 1266738000269 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1266738000270 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1266738000271 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1266738000272 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1266738000273 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1266738000274 Walker A/P-loop; other site 1266738000275 ATP binding site [chemical binding]; other site 1266738000276 Q-loop/lid; other site 1266738000277 ABC transporter signature motif; other site 1266738000278 Walker B; other site 1266738000279 D-loop; other site 1266738000280 H-loop/switch region; other site 1266738000281 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1266738000282 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1266738000283 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1266738000284 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1266738000285 putative active site [active] 1266738000286 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1266738000287 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1266738000288 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1266738000289 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1266738000290 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1266738000291 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1266738000292 Walker A/P-loop; other site 1266738000293 ATP binding site [chemical binding]; other site 1266738000294 Q-loop/lid; other site 1266738000295 ABC transporter signature motif; other site 1266738000296 Walker B; other site 1266738000297 D-loop; other site 1266738000298 H-loop/switch region; other site 1266738000299 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1266738000300 conserved hypothetical integral membrane protein; Region: TIGR00056 1266738000301 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1266738000302 mce related protein; Region: MCE; pfam02470 1266738000303 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 1266738000304 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1266738000305 anti sigma factor interaction site; other site 1266738000306 regulatory phosphorylation site [posttranslational modification]; other site 1266738000307 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1266738000308 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1266738000309 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1266738000310 hinge; other site 1266738000311 active site 1266738000312 serine endoprotease; Provisional; Region: PRK10898 1266738000313 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1266738000314 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1266738000315 protein binding site [polypeptide binding]; other site 1266738000316 serine endoprotease; Provisional; Region: PRK10139 1266738000317 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1266738000318 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1266738000319 protein binding site [polypeptide binding]; other site 1266738000320 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1266738000321 hypothetical protein; Provisional; Region: PRK11677 1266738000322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1266738000323 Predicted ATPase [General function prediction only]; Region: COG1485 1266738000324 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1266738000325 23S rRNA interface [nucleotide binding]; other site 1266738000326 L3 interface [polypeptide binding]; other site 1266738000327 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1266738000328 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1266738000329 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1266738000330 C-terminal domain interface [polypeptide binding]; other site 1266738000331 putative GSH binding site (G-site) [chemical binding]; other site 1266738000332 dimer interface [polypeptide binding]; other site 1266738000333 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1266738000334 dimer interface [polypeptide binding]; other site 1266738000335 N-terminal domain interface [polypeptide binding]; other site 1266738000336 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1266738000337 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1266738000338 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1266738000339 DNA binding residues [nucleotide binding] 1266738000340 dimer interface [polypeptide binding]; other site 1266738000341 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1266738000342 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1266738000343 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1266738000344 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 1266738000345 putative metal binding site [ion binding]; other site 1266738000346 dimer interface [polypeptide binding]; other site 1266738000347 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 1266738000348 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1266738000349 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1266738000350 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1266738000351 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1266738000352 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1266738000353 active site 1266738000354 dimer interface [polypeptide binding]; other site 1266738000355 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1266738000356 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1266738000357 active site 1266738000358 FMN binding site [chemical binding]; other site 1266738000359 substrate binding site [chemical binding]; other site 1266738000360 3Fe-4S cluster binding site [ion binding]; other site 1266738000361 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1266738000362 domain interface; other site 1266738000363 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 1266738000364 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1266738000365 putative active site [active] 1266738000366 heme pocket [chemical binding]; other site 1266738000367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1266738000368 dimer interface [polypeptide binding]; other site 1266738000369 phosphorylation site [posttranslational modification] 1266738000370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1266738000371 ATP binding site [chemical binding]; other site 1266738000372 Mg2+ binding site [ion binding]; other site 1266738000373 G-X-G motif; other site 1266738000374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738000375 active site 1266738000376 phosphorylation site [posttranslational modification] 1266738000377 intermolecular recognition site; other site 1266738000378 dimerization interface [polypeptide binding]; other site 1266738000379 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1266738000380 putative binding surface; other site 1266738000381 active site 1266738000382 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1266738000383 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1266738000384 conserved cys residue [active] 1266738000385 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1266738000386 Transglycosylase; Region: Transgly; cl17702 1266738000387 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1266738000388 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1266738000389 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1266738000390 alpha-gamma subunit interface [polypeptide binding]; other site 1266738000391 beta-gamma subunit interface [polypeptide binding]; other site 1266738000392 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1266738000393 gamma-beta subunit interface [polypeptide binding]; other site 1266738000394 alpha-beta subunit interface [polypeptide binding]; other site 1266738000395 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1266738000396 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1266738000397 subunit interactions [polypeptide binding]; other site 1266738000398 active site 1266738000399 flap region; other site 1266738000400 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1266738000401 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1266738000402 dimer interface [polypeptide binding]; other site 1266738000403 catalytic residues [active] 1266738000404 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1266738000405 UreF; Region: UreF; pfam01730 1266738000406 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1266738000407 outer membrane lipoprotein; Provisional; Region: PRK11023 1266738000408 BON domain; Region: BON; pfam04972 1266738000409 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1266738000410 dimer interface [polypeptide binding]; other site 1266738000411 active site 1266738000412 hypothetical protein; Reviewed; Region: PRK12497 1266738000413 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 1266738000414 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1266738000415 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1266738000416 putative ligand binding site [chemical binding]; other site 1266738000417 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1266738000418 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1266738000419 putative SAM binding site [chemical binding]; other site 1266738000420 putative homodimer interface [polypeptide binding]; other site 1266738000421 Pirin-related protein [General function prediction only]; Region: COG1741 1266738000422 Pirin; Region: Pirin; pfam02678 1266738000423 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738000424 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1266738000425 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1266738000426 dimerization interface [polypeptide binding]; other site 1266738000427 Predicted membrane protein [Function unknown]; Region: COG2259 1266738000428 YqjK-like protein; Region: YqjK; pfam13997 1266738000429 Predicted membrane protein [Function unknown]; Region: COG5393 1266738000430 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1266738000431 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1266738000432 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1266738000433 serine/threonine transporter SstT; Provisional; Region: PRK13628 1266738000434 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1266738000435 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1266738000436 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1266738000437 active site 1266738000438 FMN binding site [chemical binding]; other site 1266738000439 2,4-decadienoyl-CoA binding site; other site 1266738000440 catalytic residue [active] 1266738000441 4Fe-4S cluster binding site [ion binding]; other site 1266738000442 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1266738000443 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1266738000444 DoxX; Region: DoxX; pfam07681 1266738000445 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1266738000446 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1266738000447 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1266738000448 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1266738000449 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1266738000450 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1266738000451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738000452 Walker A/P-loop; other site 1266738000453 ATP binding site [chemical binding]; other site 1266738000454 Q-loop/lid; other site 1266738000455 ABC transporter signature motif; other site 1266738000456 Walker B; other site 1266738000457 D-loop; other site 1266738000458 H-loop/switch region; other site 1266738000459 Secretin and TonB N terminus short domain; Region: STN; smart00965 1266738000460 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1266738000461 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1266738000462 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 1266738000463 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1266738000464 FecR protein; Region: FecR; pfam04773 1266738000465 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1266738000466 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1266738000467 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1266738000468 DNA binding residues [nucleotide binding] 1266738000469 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1266738000470 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1266738000471 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1266738000472 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1266738000473 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1266738000474 ABC transporter; Region: ABC_tran_2; pfam12848 1266738000475 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1266738000476 lytic murein transglycosylase; Provisional; Region: PRK11619 1266738000477 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1266738000478 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1266738000479 catalytic residue [active] 1266738000480 Trp operon repressor; Provisional; Region: PRK01381 1266738000481 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 1266738000482 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1266738000483 catalytic core [active] 1266738000484 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1266738000485 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1266738000486 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1266738000487 two-component response regulator; Provisional; Region: PRK11173 1266738000488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738000489 active site 1266738000490 phosphorylation site [posttranslational modification] 1266738000491 intermolecular recognition site; other site 1266738000492 dimerization interface [polypeptide binding]; other site 1266738000493 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1266738000494 DNA binding site [nucleotide binding] 1266738000495 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1266738000496 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1266738000497 putative catalytic residues [active] 1266738000498 putative nucleotide binding site [chemical binding]; other site 1266738000499 putative aspartate binding site [chemical binding]; other site 1266738000500 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1266738000501 dimer interface [polypeptide binding]; other site 1266738000502 putative threonine allosteric regulatory site; other site 1266738000503 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1266738000504 putative threonine allosteric regulatory site; other site 1266738000505 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1266738000506 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1266738000507 homoserine kinase; Provisional; Region: PRK01212 1266738000508 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1266738000509 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1266738000510 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1266738000511 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1266738000512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738000513 catalytic residue [active] 1266738000514 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1266738000515 hypothetical protein; Validated; Region: PRK02101 1266738000516 transaldolase-like protein; Provisional; Region: PTZ00411 1266738000517 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1266738000518 active site 1266738000519 dimer interface [polypeptide binding]; other site 1266738000520 catalytic residue [active] 1266738000521 Anthrax toxin LF subunit; Region: Anthrax_toxA; pfam03497 1266738000522 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1266738000523 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1266738000524 MPT binding site; other site 1266738000525 trimer interface [polypeptide binding]; other site 1266738000526 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1266738000527 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1266738000528 nucleotide binding site [chemical binding]; other site 1266738000529 chaperone protein DnaJ; Provisional; Region: PRK10767 1266738000530 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1266738000531 HSP70 interaction site [polypeptide binding]; other site 1266738000532 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1266738000533 substrate binding site [polypeptide binding]; other site 1266738000534 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1266738000535 Zn binding sites [ion binding]; other site 1266738000536 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1266738000537 dimer interface [polypeptide binding]; other site 1266738000538 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 1266738000539 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1266738000540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738000541 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1266738000542 putative dimerization interface [polypeptide binding]; other site 1266738000543 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1266738000544 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1266738000545 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1266738000546 active site 1266738000547 Riboflavin kinase; Region: Flavokinase; smart00904 1266738000548 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1266738000549 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1266738000550 active site 1266738000551 HIGH motif; other site 1266738000552 nucleotide binding site [chemical binding]; other site 1266738000553 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1266738000554 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1266738000555 active site 1266738000556 KMSKS motif; other site 1266738000557 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1266738000558 tRNA binding surface [nucleotide binding]; other site 1266738000559 anticodon binding site; other site 1266738000560 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1266738000561 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1266738000562 lipoprotein signal peptidase; Provisional; Region: PRK14787 1266738000563 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1266738000564 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1266738000565 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1266738000566 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1266738000567 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1266738000568 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1266738000569 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1266738000570 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1266738000571 catalytic site [active] 1266738000572 subunit interface [polypeptide binding]; other site 1266738000573 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1266738000574 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1266738000575 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1266738000576 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1266738000577 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1266738000578 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1266738000579 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1266738000580 IMP binding site; other site 1266738000581 dimer interface [polypeptide binding]; other site 1266738000582 interdomain contacts; other site 1266738000583 partial ornithine binding site; other site 1266738000584 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1266738000585 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1266738000586 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1266738000587 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1266738000588 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1266738000589 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1266738000590 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1266738000591 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1266738000592 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1266738000593 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1266738000594 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1266738000595 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1266738000596 active site 1266738000597 catalytic tetrad [active] 1266738000598 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1266738000599 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1266738000600 dimer interface [polypeptide binding]; other site 1266738000601 active site 1266738000602 metal binding site [ion binding]; metal-binding site 1266738000603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738000604 S-adenosylmethionine binding site [chemical binding]; other site 1266738000605 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1266738000606 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1266738000607 cystathionine beta-lyase; Provisional; Region: PRK08114 1266738000608 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1266738000609 homodimer interface [polypeptide binding]; other site 1266738000610 substrate-cofactor binding pocket; other site 1266738000611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738000612 catalytic residue [active] 1266738000613 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1266738000614 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1266738000615 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1266738000616 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 1266738000617 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1266738000618 hydrogenase 2 large subunit; Provisional; Region: PRK10467 1266738000619 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1266738000620 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1266738000621 putative substrate-binding site; other site 1266738000622 nickel binding site [ion binding]; other site 1266738000623 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 1266738000624 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1266738000625 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1266738000626 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 1266738000627 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1266738000628 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1266738000629 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1266738000630 dimerization interface [polypeptide binding]; other site 1266738000631 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1266738000632 ATP binding site [chemical binding]; other site 1266738000633 putative inner membrane protein; Provisional; Region: PRK11099 1266738000634 Sulphur transport; Region: Sulf_transp; pfam04143 1266738000635 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 1266738000636 CPxP motif; other site 1266738000637 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1266738000638 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1266738000639 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1266738000640 eyelet of channel; other site 1266738000641 trimer interface [polypeptide binding]; other site 1266738000642 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1266738000643 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1266738000644 active site 1266738000645 metal binding site [ion binding]; metal-binding site 1266738000646 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1266738000647 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208 1266738000648 CAS motifs; other site 1266738000649 active site 1266738000650 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1266738000651 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1266738000652 putative active site [active] 1266738000653 putative metal binding site [ion binding]; other site 1266738000654 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1266738000655 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1266738000656 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1266738000657 dimer interface [polypeptide binding]; other site 1266738000658 FMN binding site [chemical binding]; other site 1266738000659 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738000660 AAA domain; Region: AAA_23; pfam13476 1266738000661 Walker A/P-loop; other site 1266738000662 ATP binding site [chemical binding]; other site 1266738000663 Q-loop/lid; other site 1266738000664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738000665 ABC transporter signature motif; other site 1266738000666 Walker B; other site 1266738000667 D-loop; other site 1266738000668 H-loop/switch region; other site 1266738000669 exonuclease subunit SbcD; Provisional; Region: PRK10966 1266738000670 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1266738000671 active site 1266738000672 metal binding site [ion binding]; metal-binding site 1266738000673 DNA binding site [nucleotide binding] 1266738000674 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1266738000675 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1266738000676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738000677 active site 1266738000678 phosphorylation site [posttranslational modification] 1266738000679 intermolecular recognition site; other site 1266738000680 dimerization interface [polypeptide binding]; other site 1266738000681 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1266738000682 DNA binding site [nucleotide binding] 1266738000683 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1266738000684 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1266738000685 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1266738000686 putative active site [active] 1266738000687 heme pocket [chemical binding]; other site 1266738000688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1266738000689 dimer interface [polypeptide binding]; other site 1266738000690 phosphorylation site [posttranslational modification] 1266738000691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1266738000692 ATP binding site [chemical binding]; other site 1266738000693 Mg2+ binding site [ion binding]; other site 1266738000694 G-X-G motif; other site 1266738000695 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1266738000696 hypothetical protein; Provisional; Region: PRK09946 1266738000697 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 1266738000698 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1266738000699 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 1266738000700 4Fe-4S binding domain; Region: Fer4; cl02805 1266738000701 hypothetical protein; Provisional; Region: PRK09947 1266738000702 putative oxidoreductase; Provisional; Region: PRK09849 1266738000703 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 1266738000704 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 1266738000705 hypothetical protein; Provisional; Region: PRK09898 1266738000706 peroxidase; Provisional; Region: PRK15000 1266738000707 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1266738000708 dimer interface [polypeptide binding]; other site 1266738000709 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1266738000710 catalytic triad [active] 1266738000711 peroxidatic and resolving cysteines [active] 1266738000712 Protein of unknown function, DUF479; Region: DUF479; cl01203 1266738000713 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1266738000714 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1266738000715 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1266738000716 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1266738000717 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1266738000718 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1266738000719 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1266738000720 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1266738000721 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1266738000722 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1266738000723 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1266738000724 Protein export membrane protein; Region: SecD_SecF; pfam02355 1266738000725 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1266738000726 ATP cone domain; Region: ATP-cone; pfam03477 1266738000727 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1266738000728 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1266738000729 catalytic motif [active] 1266738000730 Zn binding site [ion binding]; other site 1266738000731 RibD C-terminal domain; Region: RibD_C; cl17279 1266738000732 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1266738000733 homopentamer interface [polypeptide binding]; other site 1266738000734 active site 1266738000735 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1266738000736 putative RNA binding site [nucleotide binding]; other site 1266738000737 thiamine monophosphate kinase; Provisional; Region: PRK05731 1266738000738 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1266738000739 ATP binding site [chemical binding]; other site 1266738000740 dimerization interface [polypeptide binding]; other site 1266738000741 hypothetical protein; Provisional; Region: PRK10220 1266738000742 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1266738000743 PhnA protein; Region: PhnA; pfam03831 1266738000744 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1266738000745 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1266738000746 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1266738000747 Probable transposase; Region: OrfB_IS605; pfam01385 1266738000748 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1266738000749 transcriptional repressor RbsR; Provisional; Region: PRK10423 1266738000750 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1266738000751 DNA binding site [nucleotide binding] 1266738000752 domain linker motif; other site 1266738000753 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1266738000754 dimerization interface [polypeptide binding]; other site 1266738000755 ligand binding site [chemical binding]; other site 1266738000756 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1266738000757 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1266738000758 substrate binding site [chemical binding]; other site 1266738000759 dimer interface [polypeptide binding]; other site 1266738000760 ATP binding site [chemical binding]; other site 1266738000761 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1266738000762 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1266738000763 ligand binding site [chemical binding]; other site 1266738000764 dimerization interface [polypeptide binding]; other site 1266738000765 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1266738000766 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1266738000767 Walker A/P-loop; other site 1266738000768 ATP binding site [chemical binding]; other site 1266738000769 Q-loop/lid; other site 1266738000770 ABC transporter signature motif; other site 1266738000771 Walker B; other site 1266738000772 D-loop; other site 1266738000773 H-loop/switch region; other site 1266738000774 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1266738000775 D-ribose pyranase; Provisional; Region: PRK11797 1266738000776 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1266738000777 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1266738000778 TPP-binding site; other site 1266738000779 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1266738000780 PYR/PP interface [polypeptide binding]; other site 1266738000781 dimer interface [polypeptide binding]; other site 1266738000782 TPP binding site [chemical binding]; other site 1266738000783 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1266738000784 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1266738000785 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1266738000786 substrate binding pocket [chemical binding]; other site 1266738000787 chain length determination region; other site 1266738000788 substrate-Mg2+ binding site; other site 1266738000789 catalytic residues [active] 1266738000790 aspartate-rich region 1; other site 1266738000791 active site lid residues [active] 1266738000792 aspartate-rich region 2; other site 1266738000793 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1266738000794 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1266738000795 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1266738000796 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1266738000797 Ligand Binding Site [chemical binding]; other site 1266738000798 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1266738000799 active site residue [active] 1266738000800 Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; pfam13957 1266738000801 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 1266738000802 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1266738000803 conserved cys residue [active] 1266738000804 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1266738000805 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1266738000806 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1266738000807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738000808 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1266738000809 putative substrate translocation pore; other site 1266738000810 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1266738000811 UbiA prenyltransferase family; Region: UbiA; pfam01040 1266738000812 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 1266738000813 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1266738000814 Subunit I/III interface [polypeptide binding]; other site 1266738000815 Subunit III/IV interface [polypeptide binding]; other site 1266738000816 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1266738000817 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1266738000818 D-pathway; other site 1266738000819 Putative ubiquinol binding site [chemical binding]; other site 1266738000820 Low-spin heme (heme b) binding site [chemical binding]; other site 1266738000821 Putative water exit pathway; other site 1266738000822 Binuclear center (heme o3/CuB) [ion binding]; other site 1266738000823 K-pathway; other site 1266738000824 Putative proton exit pathway; other site 1266738000825 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1266738000826 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1266738000827 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1266738000828 hypothetical protein; Provisional; Region: PRK11528 1266738000829 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1266738000830 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1266738000831 ATP binding site [chemical binding]; other site 1266738000832 Mg++ binding site [ion binding]; other site 1266738000833 motif III; other site 1266738000834 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1266738000835 nucleotide binding region [chemical binding]; other site 1266738000836 ATP-binding site [chemical binding]; other site 1266738000837 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1266738000838 putative RNA binding site [nucleotide binding]; other site 1266738000839 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1266738000840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738000841 putative substrate translocation pore; other site 1266738000842 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1266738000843 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1266738000844 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1266738000845 Probable transposase; Region: OrfB_IS605; pfam01385 1266738000846 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1266738000847 BolA-like protein; Region: BolA; cl00386 1266738000848 trigger factor; Provisional; Region: tig; PRK01490 1266738000849 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1266738000850 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1266738000851 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1266738000852 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1266738000853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1266738000854 Walker A motif; other site 1266738000855 ATP binding site [chemical binding]; other site 1266738000856 Walker B motif; other site 1266738000857 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1266738000858 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1266738000859 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1266738000860 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1266738000861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1266738000862 Walker A motif; other site 1266738000863 ATP binding site [chemical binding]; other site 1266738000864 Walker B motif; other site 1266738000865 arginine finger; other site 1266738000866 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1266738000867 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1266738000868 IHF dimer interface [polypeptide binding]; other site 1266738000869 IHF - DNA interface [nucleotide binding]; other site 1266738000870 periplasmic folding chaperone; Provisional; Region: PRK10788 1266738000871 SurA N-terminal domain; Region: SurA_N_3; cl07813 1266738000872 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1266738000873 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1266738000874 Helix-hairpin-helix motif; Region: HHH; pfam00633 1266738000875 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1266738000876 active site 1266738000877 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1266738000878 Ligand Binding Site [chemical binding]; other site 1266738000879 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1266738000880 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1266738000881 putative DNA binding site [nucleotide binding]; other site 1266738000882 putative Zn2+ binding site [ion binding]; other site 1266738000883 AsnC family; Region: AsnC_trans_reg; pfam01037 1266738000884 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1266738000885 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1266738000886 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738000887 Walker A/P-loop; other site 1266738000888 ATP binding site [chemical binding]; other site 1266738000889 Q-loop/lid; other site 1266738000890 ABC transporter signature motif; other site 1266738000891 Walker B; other site 1266738000892 D-loop; other site 1266738000893 H-loop/switch region; other site 1266738000894 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1266738000895 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1266738000896 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1266738000897 Walker A/P-loop; other site 1266738000898 ATP binding site [chemical binding]; other site 1266738000899 Q-loop/lid; other site 1266738000900 ABC transporter signature motif; other site 1266738000901 Walker B; other site 1266738000902 D-loop; other site 1266738000903 H-loop/switch region; other site 1266738000904 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1266738000905 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1266738000906 ammonium transporter; Provisional; Region: PRK10666 1266738000907 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1266738000908 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1266738000909 active site 1266738000910 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1266738000911 catalytic triad [active] 1266738000912 dimer interface [polypeptide binding]; other site 1266738000913 Hha toxicity attenuator; Provisional; Region: PRK10667 1266738000914 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1266738000915 Protein export membrane protein; Region: SecD_SecF; cl14618 1266738000916 Protein export membrane protein; Region: SecD_SecF; cl14618 1266738000917 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1266738000918 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1266738000919 HlyD family secretion protein; Region: HlyD_3; pfam13437 1266738000920 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1266738000921 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1266738000922 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1266738000923 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 1266738000924 hypothetical protein; Provisional; Region: PRK11281 1266738000925 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 1266738000926 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1266738000927 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1266738000928 hypothetical protein; Provisional; Region: PRK11038 1266738000929 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 1266738000930 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1266738000931 active site 1266738000932 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1266738000933 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1266738000934 Walker A motif; other site 1266738000935 ATP binding site [chemical binding]; other site 1266738000936 Walker B motif; other site 1266738000937 arginine finger; other site 1266738000938 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1266738000939 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1266738000940 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1266738000941 recombination protein RecR; Reviewed; Region: recR; PRK00076 1266738000942 RecR protein; Region: RecR; pfam02132 1266738000943 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1266738000944 putative active site [active] 1266738000945 putative metal-binding site [ion binding]; other site 1266738000946 tetramer interface [polypeptide binding]; other site 1266738000947 carbon starvation protein A; Provisional; Region: PRK15015 1266738000948 Carbon starvation protein CstA; Region: CstA; pfam02554 1266738000949 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1266738000950 Uncharacterized small protein [Function unknown]; Region: COG2879 1266738000951 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1266738000952 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1266738000953 P-loop, Walker A motif; other site 1266738000954 Base recognition motif; other site 1266738000955 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1266738000956 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1266738000957 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 1266738000958 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1266738000959 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1266738000960 peptidase T; Region: peptidase-T; TIGR01882 1266738000961 metal binding site [ion binding]; metal-binding site 1266738000962 dimer interface [polypeptide binding]; other site 1266738000963 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1266738000964 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1266738000965 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 1266738000966 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1266738000967 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 1266738000968 hypothetical protein; Provisional; Region: PRK02399 1266738000969 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 1266738000970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1266738000971 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1266738000972 DNA-binding interface [nucleotide binding]; DNA binding site 1266738000973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1266738000974 YheO-like PAS domain; Region: PAS_6; pfam08348 1266738000975 HTH domain; Region: HTH_22; pfam13309 1266738000976 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1266738000977 Coenzyme A binding pocket [chemical binding]; other site 1266738000978 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1266738000979 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1266738000980 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1266738000981 multicopper oxidase; Provisional; Region: PRK10965 1266738000982 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1266738000983 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1266738000984 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1266738000985 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1266738000986 active site 1266738000987 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1266738000988 active site clefts [active] 1266738000989 zinc binding site [ion binding]; other site 1266738000990 dimer interface [polypeptide binding]; other site 1266738000991 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1266738000992 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1266738000993 Walker A/P-loop; other site 1266738000994 ATP binding site [chemical binding]; other site 1266738000995 Q-loop/lid; other site 1266738000996 ABC transporter signature motif; other site 1266738000997 Walker B; other site 1266738000998 D-loop; other site 1266738000999 H-loop/switch region; other site 1266738001000 inner membrane transport permease; Provisional; Region: PRK15066 1266738001001 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1266738001002 benzoate transport; Region: 2A0115; TIGR00895 1266738001003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738001004 putative substrate translocation pore; other site 1266738001005 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 1266738001006 Peptidase family M48; Region: Peptidase_M48; cl12018 1266738001007 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1266738001008 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1266738001009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1266738001010 Probable transposase; Region: OrfB_IS605; pfam01385 1266738001011 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1266738001012 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1266738001013 Bacterial transcriptional regulator; Region: IclR; pfam01614 1266738001014 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1266738001015 Imelysin; Region: Peptidase_M75; cl09159 1266738001016 Iron permease FTR1 family; Region: FTR1; cl00475 1266738001017 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1266738001018 Fe2+ transport protein; Region: Iron_transport; pfam10634 1266738001019 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1266738001020 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738001021 non-specific DNA binding site [nucleotide binding]; other site 1266738001022 salt bridge; other site 1266738001023 sequence-specific DNA binding site [nucleotide binding]; other site 1266738001024 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 1266738001025 CHAP domain; Region: CHAP; pfam05257 1266738001026 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1266738001027 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 1266738001028 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738001029 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1266738001030 dimerization interface [polypeptide binding]; other site 1266738001031 substrate binding pocket [chemical binding]; other site 1266738001032 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1266738001033 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1266738001034 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1266738001035 catalytic residue [active] 1266738001036 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 1266738001037 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1266738001038 Walker A/P-loop; other site 1266738001039 ATP binding site [chemical binding]; other site 1266738001040 Q-loop/lid; other site 1266738001041 ABC transporter signature motif; other site 1266738001042 Walker B; other site 1266738001043 D-loop; other site 1266738001044 H-loop/switch region; other site 1266738001045 TOBE domain; Region: TOBE_2; pfam08402 1266738001046 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1266738001047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738001048 dimer interface [polypeptide binding]; other site 1266738001049 conserved gate region; other site 1266738001050 putative PBP binding loops; other site 1266738001051 ABC-ATPase subunit interface; other site 1266738001052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738001053 dimer interface [polypeptide binding]; other site 1266738001054 conserved gate region; other site 1266738001055 putative PBP binding loops; other site 1266738001056 ABC-ATPase subunit interface; other site 1266738001057 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1266738001058 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1266738001059 regulatory protein UhpC; Provisional; Region: PRK11663 1266738001060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738001061 putative substrate translocation pore; other site 1266738001062 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 1266738001063 MASE1; Region: MASE1; pfam05231 1266738001064 Histidine kinase; Region: HisKA_3; pfam07730 1266738001065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1266738001066 ATP binding site [chemical binding]; other site 1266738001067 Mg2+ binding site [ion binding]; other site 1266738001068 G-X-G motif; other site 1266738001069 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1266738001070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738001071 active site 1266738001072 phosphorylation site [posttranslational modification] 1266738001073 intermolecular recognition site; other site 1266738001074 dimerization interface [polypeptide binding]; other site 1266738001075 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1266738001076 DNA binding residues [nucleotide binding] 1266738001077 dimerization interface [polypeptide binding]; other site 1266738001078 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1266738001079 tetramerization interface [polypeptide binding]; other site 1266738001080 active site 1266738001081 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1266738001082 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1266738001083 active site 1266738001084 ATP-binding site [chemical binding]; other site 1266738001085 pantoate-binding site; other site 1266738001086 HXXH motif; other site 1266738001087 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1266738001088 oligomerization interface [polypeptide binding]; other site 1266738001089 active site 1266738001090 metal binding site [ion binding]; metal-binding site 1266738001091 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1266738001092 catalytic center binding site [active] 1266738001093 ATP binding site [chemical binding]; other site 1266738001094 poly(A) polymerase; Region: pcnB; TIGR01942 1266738001095 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1266738001096 active site 1266738001097 NTP binding site [chemical binding]; other site 1266738001098 metal binding triad [ion binding]; metal-binding site 1266738001099 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1266738001100 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1266738001101 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 1266738001102 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1266738001103 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1266738001104 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1266738001105 ATP binding site [chemical binding]; other site 1266738001106 putative Mg++ binding site [ion binding]; other site 1266738001107 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1266738001108 nucleotide binding region [chemical binding]; other site 1266738001109 ATP-binding site [chemical binding]; other site 1266738001110 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1266738001111 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1266738001112 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1266738001113 Transglycosylase; Region: Transgly; pfam00912 1266738001114 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1266738001115 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1266738001116 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1266738001117 inhibitor-cofactor binding pocket; inhibition site 1266738001118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738001119 catalytic residue [active] 1266738001120 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1266738001121 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1266738001122 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1266738001123 cobalamin binding residues [chemical binding]; other site 1266738001124 putative BtuC binding residues; other site 1266738001125 dimer interface [polypeptide binding]; other site 1266738001126 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1266738001127 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1266738001128 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1266738001129 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1266738001130 Zn2+ binding site [ion binding]; other site 1266738001131 Mg2+ binding site [ion binding]; other site 1266738001132 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1266738001133 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1266738001134 TRAM domain; Region: TRAM; pfam01938 1266738001135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738001136 S-adenosylmethionine binding site [chemical binding]; other site 1266738001137 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1266738001138 HD domain; Region: HD_4; pfam13328 1266738001139 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1266738001140 synthetase active site [active] 1266738001141 NTP binding site [chemical binding]; other site 1266738001142 metal binding site [ion binding]; metal-binding site 1266738001143 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1266738001144 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1266738001145 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1266738001146 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1266738001147 homodimer interface [polypeptide binding]; other site 1266738001148 metal binding site [ion binding]; metal-binding site 1266738001149 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1266738001150 homodimer interface [polypeptide binding]; other site 1266738001151 active site 1266738001152 putative chemical substrate binding site [chemical binding]; other site 1266738001153 metal binding site [ion binding]; metal-binding site 1266738001154 CTP synthetase; Validated; Region: pyrG; PRK05380 1266738001155 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1266738001156 Catalytic site [active] 1266738001157 active site 1266738001158 UTP binding site [chemical binding]; other site 1266738001159 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1266738001160 active site 1266738001161 putative oxyanion hole; other site 1266738001162 catalytic triad [active] 1266738001163 enolase; Provisional; Region: eno; PRK00077 1266738001164 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1266738001165 dimer interface [polypeptide binding]; other site 1266738001166 metal binding site [ion binding]; metal-binding site 1266738001167 substrate binding pocket [chemical binding]; other site 1266738001168 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1266738001169 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1266738001170 transmembrane helices; other site 1266738001171 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1266738001172 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1266738001173 dimer interface [polypeptide binding]; other site 1266738001174 PYR/PP interface [polypeptide binding]; other site 1266738001175 TPP binding site [chemical binding]; other site 1266738001176 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1266738001177 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1266738001178 TPP-binding site [chemical binding]; other site 1266738001179 dimer interface [polypeptide binding]; other site 1266738001180 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1266738001181 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1266738001182 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1266738001183 catalytic residue [active] 1266738001184 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1266738001185 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1266738001186 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1266738001187 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1266738001188 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1266738001189 RNA/DNA hybrid binding site [nucleotide binding]; other site 1266738001190 active site 1266738001191 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1266738001192 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1266738001193 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1266738001194 ABC-ATPase subunit interface; other site 1266738001195 dimer interface [polypeptide binding]; other site 1266738001196 putative PBP binding regions; other site 1266738001197 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1266738001198 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1266738001199 Walker A/P-loop; other site 1266738001200 ATP binding site [chemical binding]; other site 1266738001201 Q-loop/lid; other site 1266738001202 ABC transporter signature motif; other site 1266738001203 Walker B; other site 1266738001204 D-loop; other site 1266738001205 H-loop/switch region; other site 1266738001206 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1266738001207 IucA / IucC family; Region: IucA_IucC; pfam04183 1266738001208 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1266738001209 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1266738001210 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1266738001211 N-terminal plug; other site 1266738001212 ligand-binding site [chemical binding]; other site 1266738001213 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1266738001214 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 1266738001215 dimer interface [polypeptide binding]; other site 1266738001216 active site 1266738001217 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1266738001218 catalytic residues [active] 1266738001219 substrate binding site [chemical binding]; other site 1266738001220 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1266738001221 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1266738001222 dimer interface [polypeptide binding]; other site 1266738001223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738001224 catalytic residue [active] 1266738001225 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1266738001226 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 1266738001227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738001228 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1266738001229 putative substrate translocation pore; other site 1266738001230 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1266738001231 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 1266738001232 putative ligand binding residues [chemical binding]; other site 1266738001233 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1266738001234 ParB-like nuclease domain; Region: ParBc; cl02129 1266738001235 transketolase; Reviewed; Region: PRK12753 1266738001236 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1266738001237 TPP-binding site [chemical binding]; other site 1266738001238 dimer interface [polypeptide binding]; other site 1266738001239 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1266738001240 PYR/PP interface [polypeptide binding]; other site 1266738001241 dimer interface [polypeptide binding]; other site 1266738001242 TPP binding site [chemical binding]; other site 1266738001243 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1266738001244 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1266738001245 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1266738001246 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1266738001247 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1266738001248 Phosphoglycerate kinase; Region: PGK; pfam00162 1266738001249 substrate binding site [chemical binding]; other site 1266738001250 hinge regions; other site 1266738001251 ADP binding site [chemical binding]; other site 1266738001252 catalytic site [active] 1266738001253 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1266738001254 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1266738001255 active site 1266738001256 intersubunit interface [polypeptide binding]; other site 1266738001257 zinc binding site [ion binding]; other site 1266738001258 Na+ binding site [ion binding]; other site 1266738001259 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1266738001260 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1266738001261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738001262 putative substrate translocation pore; other site 1266738001263 POT family; Region: PTR2; pfam00854 1266738001264 Flavin Reductases; Region: FlaRed; cl00801 1266738001265 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 1266738001266 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1266738001267 BCCT family transporter; Region: BCCT; cl00569 1266738001268 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 1266738001269 Predicted membrane protein [Function unknown]; Region: COG2323 1266738001270 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1266738001271 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 1266738001272 PapC N-terminal domain; Region: PapC_N; pfam13954 1266738001273 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1266738001274 PapC C-terminal domain; Region: PapC_C; pfam13953 1266738001275 putative periplasmic fimbrial chaperone protein SteC; Provisional; Region: PRK15274 1266738001276 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1266738001277 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1266738001278 Fimbrial protein; Region: Fimbrial; cl01416 1266738001279 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1266738001280 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1266738001281 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738001282 non-specific DNA binding site [nucleotide binding]; other site 1266738001283 salt bridge; other site 1266738001284 sequence-specific DNA binding site [nucleotide binding]; other site 1266738001285 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 1266738001286 Int/Topo IB signature motif; other site 1266738001287 Fimbrial protein; Region: Fimbrial; cl01416 1266738001288 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 1266738001289 PapC N-terminal domain; Region: PapC_N; pfam13954 1266738001290 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1266738001291 PapC C-terminal domain; Region: PapC_C; pfam13953 1266738001292 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 1266738001293 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1266738001294 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1266738001295 Fimbrial protein; Region: Fimbrial; pfam00419 1266738001296 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1266738001297 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1266738001298 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738001299 non-specific DNA binding site [nucleotide binding]; other site 1266738001300 salt bridge; other site 1266738001301 sequence-specific DNA binding site [nucleotide binding]; other site 1266738001302 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1266738001303 AbgT putative transporter family; Region: ABG_transport; pfam03806 1266738001304 hypothetical protein; Provisional; Region: PRK10203 1266738001305 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1266738001306 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1266738001307 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1266738001308 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1266738001309 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1266738001310 HlyD family secretion protein; Region: HlyD_3; pfam13437 1266738001311 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1266738001312 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1266738001313 Walker A/P-loop; other site 1266738001314 ATP binding site [chemical binding]; other site 1266738001315 Q-loop/lid; other site 1266738001316 ABC transporter signature motif; other site 1266738001317 Walker B; other site 1266738001318 D-loop; other site 1266738001319 H-loop/switch region; other site 1266738001320 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1266738001321 active site 1266738001322 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1266738001323 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1266738001324 active site 1266738001325 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1266738001326 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1266738001327 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1266738001328 active site 1266738001329 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1266738001330 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1266738001331 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1266738001332 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1266738001333 active site 1266738001334 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1266738001335 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1266738001336 Hemolysin-type calcium-binding repeat (2 copies); Region: HemolysinCabind; pfam00353 1266738001337 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1266738001338 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738001339 non-specific DNA binding site [nucleotide binding]; other site 1266738001340 salt bridge; other site 1266738001341 sequence-specific DNA binding site [nucleotide binding]; other site 1266738001342 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1266738001343 allantoate amidohydrolase; Reviewed; Region: PRK09290 1266738001344 active site 1266738001345 metal binding site [ion binding]; metal-binding site 1266738001346 dimer interface [polypeptide binding]; other site 1266738001347 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1266738001348 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1266738001349 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1266738001350 motif II; other site 1266738001351 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1266738001352 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1266738001353 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1266738001354 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1266738001355 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 1266738001356 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1266738001357 active site turn [active] 1266738001358 phosphorylation site [posttranslational modification] 1266738001359 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1266738001360 trehalose repressor; Provisional; Region: treR; PRK09492 1266738001361 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1266738001362 DNA binding site [nucleotide binding] 1266738001363 domain linker motif; other site 1266738001364 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1266738001365 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1266738001366 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1266738001367 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1266738001368 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1266738001369 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1266738001370 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1266738001371 putative active site [active] 1266738001372 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1266738001373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738001374 Walker A/P-loop; other site 1266738001375 ATP binding site [chemical binding]; other site 1266738001376 Q-loop/lid; other site 1266738001377 ABC transporter signature motif; other site 1266738001378 Walker B; other site 1266738001379 D-loop; other site 1266738001380 H-loop/switch region; other site 1266738001381 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1266738001382 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1266738001383 HlyD family secretion protein; Region: HlyD_3; pfam13437 1266738001384 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1266738001385 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1266738001386 putrescine transporter; Provisional; Region: potE; PRK10655 1266738001387 ornithine decarboxylase; Provisional; Region: PRK13578 1266738001388 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1266738001389 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1266738001390 homodimer interface [polypeptide binding]; other site 1266738001391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738001392 catalytic residue [active] 1266738001393 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1266738001394 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1266738001395 active site 1266738001396 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1266738001397 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738001398 non-specific DNA binding site [nucleotide binding]; other site 1266738001399 salt bridge; other site 1266738001400 sequence-specific DNA binding site [nucleotide binding]; other site 1266738001401 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1266738001402 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1266738001403 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1266738001404 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1266738001405 catalytic residue [active] 1266738001406 oxidative damage protection protein; Provisional; Region: PRK05408 1266738001407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738001408 S-adenosylmethionine binding site [chemical binding]; other site 1266738001409 hypothetical protein; Provisional; Region: PRK11702 1266738001410 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1266738001411 glutaminase; Provisional; Region: PRK00971 1266738001412 hypothetical protein; Provisional; Region: PRK10626 1266738001413 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1266738001414 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1266738001415 putative ligand binding residues [chemical binding]; other site 1266738001416 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1266738001417 HemN family oxidoreductase; Provisional; Region: PRK05660 1266738001418 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1266738001419 FeS/SAM binding site; other site 1266738001420 HemN C-terminal domain; Region: HemN_C; pfam06969 1266738001421 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1266738001422 active site 1266738001423 dimerization interface [polypeptide binding]; other site 1266738001424 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1266738001425 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1266738001426 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1266738001427 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1266738001428 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1266738001429 Walker A motif; other site 1266738001430 ATP binding site [chemical binding]; other site 1266738001431 Walker B motif; other site 1266738001432 hypothetical protein; Validated; Region: PRK00228 1266738001433 glutathione synthetase; Provisional; Region: PRK05246 1266738001434 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1266738001435 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1266738001436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1266738001437 RNA methyltransferase, RsmE family; Region: TIGR00046 1266738001438 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1266738001439 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1266738001440 catalytic residues [active] 1266738001441 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1266738001442 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1266738001443 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738001444 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1266738001445 putative effector binding pocket; other site 1266738001446 dimerization interface [polypeptide binding]; other site 1266738001447 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1266738001448 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738001449 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1266738001450 dimerization interface [polypeptide binding]; other site 1266738001451 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1266738001452 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1266738001453 active site 1266738001454 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1266738001455 substrate binding site [chemical binding]; other site 1266738001456 catalytic residues [active] 1266738001457 dimer interface [polypeptide binding]; other site 1266738001458 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1266738001459 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1266738001460 active site 1266738001461 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1266738001462 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1266738001463 dimer interface [polypeptide binding]; other site 1266738001464 active site 1266738001465 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1266738001466 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1266738001467 putative active site [active] 1266738001468 putative dimer interface [polypeptide binding]; other site 1266738001469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1266738001470 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 1266738001471 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 1266738001472 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 1266738001473 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 1266738001474 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 1266738001475 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 1266738001476 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1266738001477 catalytic loop [active] 1266738001478 iron binding site [ion binding]; other site 1266738001479 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 1266738001480 FAD binding pocket [chemical binding]; other site 1266738001481 FAD binding motif [chemical binding]; other site 1266738001482 phosphate binding motif [ion binding]; other site 1266738001483 beta-alpha-beta structure motif; other site 1266738001484 NAD binding pocket [chemical binding]; other site 1266738001485 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1266738001486 ApbE family; Region: ApbE; pfam02424 1266738001487 CsbD-like; Region: CsbD; cl17424 1266738001488 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1266738001489 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1266738001490 active site 1266738001491 catalytic site [active] 1266738001492 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1266738001493 active site 1266738001494 DNA polymerase IV; Validated; Region: PRK02406 1266738001495 DNA binding site [nucleotide binding] 1266738001496 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1266738001497 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1266738001498 N-terminal plug; other site 1266738001499 ligand-binding site [chemical binding]; other site 1266738001500 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1266738001501 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1266738001502 metal binding site [ion binding]; metal-binding site 1266738001503 dimer interface [polypeptide binding]; other site 1266738001504 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1266738001505 active site 1266738001506 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 1266738001507 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 1266738001508 gamma-glutamyl kinase; Provisional; Region: PRK05429 1266738001509 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1266738001510 nucleotide binding site [chemical binding]; other site 1266738001511 homotetrameric interface [polypeptide binding]; other site 1266738001512 putative phosphate binding site [ion binding]; other site 1266738001513 putative allosteric binding site; other site 1266738001514 PUA domain; Region: PUA; pfam01472 1266738001515 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1266738001516 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1266738001517 putative catalytic cysteine [active] 1266738001518 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1266738001519 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1266738001520 ADP binding site [chemical binding]; other site 1266738001521 magnesium binding site [ion binding]; other site 1266738001522 putative shikimate binding site; other site 1266738001523 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1266738001524 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1266738001525 putative acyl-acceptor binding pocket; other site 1266738001526 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1266738001527 acyl-activating enzyme (AAE) consensus motif; other site 1266738001528 putative AMP binding site [chemical binding]; other site 1266738001529 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1266738001530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738001531 putative substrate translocation pore; other site 1266738001532 hypothetical protein; Validated; Region: PRK03661 1266738001533 recombinase A; Provisional; Region: recA; PRK09354 1266738001534 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1266738001535 hexamer interface [polypeptide binding]; other site 1266738001536 Walker A motif; other site 1266738001537 ATP binding site [chemical binding]; other site 1266738001538 Walker B motif; other site 1266738001539 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1266738001540 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1266738001541 active site 1266738001542 motif 2; other site 1266738001543 motif 3; other site 1266738001544 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1266738001545 DHHA1 domain; Region: DHHA1; pfam02272 1266738001546 carbon storage regulator; Provisional; Region: PRK01712 1266738001547 glutamate--cysteine ligase; Provisional; Region: PRK02107 1266738001548 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1266738001549 hypothetical protein; Provisional; Region: PRK11573 1266738001550 Domain of unknown function DUF21; Region: DUF21; pfam01595 1266738001551 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1266738001552 Transporter associated domain; Region: CorC_HlyC; smart01091 1266738001553 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1266738001554 signal recognition particle protein; Provisional; Region: PRK10867 1266738001555 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1266738001556 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1266738001557 P loop; other site 1266738001558 GTP binding site [chemical binding]; other site 1266738001559 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1266738001560 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1266738001561 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1266738001562 RimM N-terminal domain; Region: RimM; pfam01782 1266738001563 PRC-barrel domain; Region: PRC; pfam05239 1266738001564 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1266738001565 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1266738001566 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1266738001567 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1266738001568 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1266738001569 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 1266738001570 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1266738001571 prephenate dehydrogenase; Validated; Region: PRK08507 1266738001572 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1266738001573 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1266738001574 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1266738001575 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1266738001576 Prephenate dehydratase; Region: PDT; pfam00800 1266738001577 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1266738001578 putative L-Phe binding site [chemical binding]; other site 1266738001579 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1266738001580 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1266738001581 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1266738001582 RNA binding surface [nucleotide binding]; other site 1266738001583 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1266738001584 active site 1266738001585 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1266738001586 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1266738001587 protein disaggregation chaperone; Provisional; Region: PRK10865 1266738001588 Clp amino terminal domain; Region: Clp_N; pfam02861 1266738001589 Clp amino terminal domain; Region: Clp_N; pfam02861 1266738001590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1266738001591 Walker A motif; other site 1266738001592 ATP binding site [chemical binding]; other site 1266738001593 Walker B motif; other site 1266738001594 arginine finger; other site 1266738001595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1266738001596 Walker A motif; other site 1266738001597 ATP binding site [chemical binding]; other site 1266738001598 Walker B motif; other site 1266738001599 arginine finger; other site 1266738001600 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1266738001601 lipoprotein; Provisional; Region: PRK10759 1266738001602 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1266738001603 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1266738001604 domain interface [polypeptide binding]; other site 1266738001605 putative active site [active] 1266738001606 catalytic site [active] 1266738001607 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1266738001608 domain interface [polypeptide binding]; other site 1266738001609 putative active site [active] 1266738001610 catalytic site [active] 1266738001611 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1266738001612 CoA binding domain; Region: CoA_binding_2; pfam13380 1266738001613 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1266738001614 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1266738001615 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1266738001616 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1266738001617 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1266738001618 deubiquitinase; Provisional; Region: PRK11836; cl08202 1266738001619 putative methyltransferase; Provisional; Region: PRK10864 1266738001620 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1266738001621 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1266738001622 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1266738001623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738001624 putative substrate translocation pore; other site 1266738001625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738001626 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1266738001627 HlyD family secretion protein; Region: HlyD_3; pfam13437 1266738001628 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1266738001629 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1266738001630 DNA-binding site [nucleotide binding]; DNA binding site 1266738001631 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1266738001632 drug efflux system protein MdtG; Provisional; Region: PRK09874 1266738001633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738001634 putative substrate translocation pore; other site 1266738001635 Isochorismatase family; Region: Isochorismatase; pfam00857 1266738001636 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1266738001637 catalytic triad [active] 1266738001638 conserved cis-peptide bond; other site 1266738001639 transcriptional repressor MprA; Provisional; Region: PRK10870 1266738001640 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1266738001641 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1266738001642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738001643 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1266738001644 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1266738001645 N-terminal plug; other site 1266738001646 ligand-binding site [chemical binding]; other site 1266738001647 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1266738001648 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1266738001649 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1266738001650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738001651 dimer interface [polypeptide binding]; other site 1266738001652 conserved gate region; other site 1266738001653 putative PBP binding loops; other site 1266738001654 ABC-ATPase subunit interface; other site 1266738001655 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1266738001656 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1266738001657 Walker A/P-loop; other site 1266738001658 ATP binding site [chemical binding]; other site 1266738001659 Q-loop/lid; other site 1266738001660 ABC transporter signature motif; other site 1266738001661 Walker B; other site 1266738001662 D-loop; other site 1266738001663 H-loop/switch region; other site 1266738001664 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1266738001665 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1266738001666 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1266738001667 dimer interface [polypeptide binding]; other site 1266738001668 putative radical transfer pathway; other site 1266738001669 diiron center [ion binding]; other site 1266738001670 tyrosyl radical; other site 1266738001671 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1266738001672 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1266738001673 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1266738001674 active site 1266738001675 dimer interface [polypeptide binding]; other site 1266738001676 catalytic residues [active] 1266738001677 effector binding site; other site 1266738001678 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1266738001679 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1266738001680 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1266738001681 catalytic residues [active] 1266738001682 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1266738001683 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1266738001684 DNA binding site [nucleotide binding] 1266738001685 active site 1266738001686 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1266738001687 DNA-binding site [nucleotide binding]; DNA binding site 1266738001688 RNA-binding motif; other site 1266738001689 chromosome condensation membrane protein; Provisional; Region: PRK14196 1266738001690 lipoyl synthase; Provisional; Region: PRK05481 1266738001691 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1266738001692 FeS/SAM binding site; other site 1266738001693 lipoate-protein ligase B; Provisional; Region: PRK14342 1266738001694 hypothetical protein; Provisional; Region: PRK04998 1266738001695 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1266738001696 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1266738001697 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1266738001698 rare lipoprotein A; Provisional; Region: PRK10672 1266738001699 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 1266738001700 Sporulation related domain; Region: SPOR; pfam05036 1266738001701 cell wall shape-determining protein; Provisional; Region: PRK10794 1266738001702 penicillin-binding protein 2; Provisional; Region: PRK10795 1266738001703 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1266738001704 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1266738001705 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1266738001706 ribosome-associated protein; Provisional; Region: PRK11538 1266738001707 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1266738001708 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1266738001709 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1266738001710 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1266738001711 active site 1266738001712 (T/H)XGH motif; other site 1266738001713 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1266738001714 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1266738001715 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 1266738001716 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1266738001717 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1266738001718 HIGH motif; other site 1266738001719 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1266738001720 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1266738001721 active site 1266738001722 KMSKS motif; other site 1266738001723 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1266738001724 tRNA binding surface [nucleotide binding]; other site 1266738001725 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1266738001726 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1266738001727 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1266738001728 Walker A/P-loop; other site 1266738001729 ATP binding site [chemical binding]; other site 1266738001730 Q-loop/lid; other site 1266738001731 ABC transporter signature motif; other site 1266738001732 Walker B; other site 1266738001733 D-loop; other site 1266738001734 H-loop/switch region; other site 1266738001735 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1266738001736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738001737 dimer interface [polypeptide binding]; other site 1266738001738 conserved gate region; other site 1266738001739 putative PBP binding loops; other site 1266738001740 ABC-ATPase subunit interface; other site 1266738001741 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1266738001742 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1266738001743 substrate binding pocket [chemical binding]; other site 1266738001744 membrane-bound complex binding site; other site 1266738001745 hinge residues; other site 1266738001746 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 1266738001747 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1266738001748 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1266738001749 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1266738001750 DsbD alpha interface [polypeptide binding]; other site 1266738001751 catalytic residues [active] 1266738001752 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1266738001753 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1266738001754 catalytic residues [active] 1266738001755 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1266738001756 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1266738001757 catalytic residues [active] 1266738001758 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1266738001759 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1266738001760 putative active site [active] 1266738001761 catalytic triad [active] 1266738001762 putative dimer interface [polypeptide binding]; other site 1266738001763 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1266738001764 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1266738001765 Transporter associated domain; Region: CorC_HlyC; smart01091 1266738001766 metal-binding heat shock protein; Provisional; Region: PRK00016 1266738001767 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1266738001768 PhoH-like protein; Region: PhoH; pfam02562 1266738001769 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1266738001770 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1266738001771 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1266738001772 FeS/SAM binding site; other site 1266738001773 TRAM domain; Region: TRAM; pfam01938 1266738001774 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1266738001775 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1266738001776 S-formylglutathione hydrolase; Region: PLN02442 1266738001777 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1266738001778 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1266738001779 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1266738001780 substrate binding site [chemical binding]; other site 1266738001781 catalytic Zn binding site [ion binding]; other site 1266738001782 NAD binding site [chemical binding]; other site 1266738001783 structural Zn binding site [ion binding]; other site 1266738001784 dimer interface [polypeptide binding]; other site 1266738001785 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1266738001786 putative metal binding site [ion binding]; other site 1266738001787 putative homodimer interface [polypeptide binding]; other site 1266738001788 putative homotetramer interface [polypeptide binding]; other site 1266738001789 putative homodimer-homodimer interface [polypeptide binding]; other site 1266738001790 putative allosteric switch controlling residues; other site 1266738001791 MarR family; Region: MarR; pfam01047 1266738001792 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1266738001793 ROK family; Region: ROK; pfam00480 1266738001794 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1266738001795 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1266738001796 active site 1266738001797 dimer interface [polypeptide binding]; other site 1266738001798 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1266738001799 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1266738001800 active site 1266738001801 trimer interface [polypeptide binding]; other site 1266738001802 allosteric site; other site 1266738001803 active site lid [active] 1266738001804 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1266738001805 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1266738001806 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1266738001807 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1266738001808 active site turn [active] 1266738001809 phosphorylation site [posttranslational modification] 1266738001810 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1266738001811 HPr interaction site; other site 1266738001812 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1266738001813 active site 1266738001814 phosphorylation site [posttranslational modification] 1266738001815 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1266738001816 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1266738001817 active site 1266738001818 HIGH motif; other site 1266738001819 nucleotide binding site [chemical binding]; other site 1266738001820 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1266738001821 KMSKS motif; other site 1266738001822 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1266738001823 outer membrane porin, OprD family; Region: OprD; pfam03573 1266738001824 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 1266738001825 ferric uptake regulator; Provisional; Region: fur; PRK09462 1266738001826 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1266738001827 metal binding site 2 [ion binding]; metal-binding site 1266738001828 putative DNA binding helix; other site 1266738001829 metal binding site 1 [ion binding]; metal-binding site 1266738001830 dimer interface [polypeptide binding]; other site 1266738001831 structural Zn2+ binding site [ion binding]; other site 1266738001832 flavodoxin FldA; Validated; Region: PRK09267 1266738001833 LexA regulated protein; Provisional; Region: PRK11675 1266738001834 acyl-CoA esterase; Provisional; Region: PRK10673 1266738001835 PGAP1-like protein; Region: PGAP1; pfam07819 1266738001836 replication initiation regulator SeqA; Provisional; Region: PRK11187 1266738001837 phosphoglucomutase; Validated; Region: PRK07564 1266738001838 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1266738001839 active site 1266738001840 substrate binding site [chemical binding]; other site 1266738001841 metal binding site [ion binding]; metal-binding site 1266738001842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1266738001843 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1266738001844 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1266738001845 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 1266738001846 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1266738001847 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 1266738001848 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1266738001849 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1266738001850 SWIM zinc finger; Region: SWIM; pfam04434 1266738001851 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1266738001852 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1266738001853 metal ion-dependent adhesion site (MIDAS); other site 1266738001854 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1266738001855 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1266738001856 HEAT repeats; Region: HEAT_2; pfam13646 1266738001857 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1266738001858 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1266738001859 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1266738001860 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1266738001861 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1266738001862 dimer interface [polypeptide binding]; other site 1266738001863 active site 1266738001864 citrylCoA binding site [chemical binding]; other site 1266738001865 NADH binding [chemical binding]; other site 1266738001866 cationic pore residues; other site 1266738001867 oxalacetate/citrate binding site [chemical binding]; other site 1266738001868 coenzyme A binding site [chemical binding]; other site 1266738001869 catalytic triad [active] 1266738001870 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1266738001871 Iron-sulfur protein interface; other site 1266738001872 proximal quinone binding site [chemical binding]; other site 1266738001873 SdhD (CybS) interface [polypeptide binding]; other site 1266738001874 proximal heme binding site [chemical binding]; other site 1266738001875 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1266738001876 L-aspartate oxidase; Provisional; Region: PRK06175 1266738001877 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1266738001878 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1266738001879 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1266738001880 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1266738001881 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1266738001882 E3 interaction surface; other site 1266738001883 lipoyl attachment site [posttranslational modification]; other site 1266738001884 e3 binding domain; Region: E3_binding; pfam02817 1266738001885 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1266738001886 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1266738001887 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1266738001888 CoA-ligase; Region: Ligase_CoA; pfam00549 1266738001889 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1266738001890 CoA binding domain; Region: CoA_binding; smart00881 1266738001891 CoA-ligase; Region: Ligase_CoA; pfam00549 1266738001892 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1266738001893 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1266738001894 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1266738001895 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1266738001896 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1266738001897 hypothetical protein; Provisional; Region: PRK10588 1266738001898 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1266738001899 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738001900 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1266738001901 putative effector binding pocket; other site 1266738001902 dimerization interface [polypeptide binding]; other site 1266738001903 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1266738001904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738001905 putative substrate translocation pore; other site 1266738001906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738001907 putative substrate translocation pore; other site 1266738001908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1266738001909 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1266738001910 active site 1266738001911 colicin uptake protein TolR; Provisional; Region: PRK11024 1266738001912 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1266738001913 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1266738001914 TolA C-terminal; Region: TolA; pfam06519 1266738001915 translocation protein TolB; Provisional; Region: tolB; PRK03629 1266738001916 TolB amino-terminal domain; Region: TolB_N; pfam04052 1266738001917 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1266738001918 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1266738001919 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1266738001920 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1266738001921 ligand binding site [chemical binding]; other site 1266738001922 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1266738001923 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1266738001924 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1266738001925 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1266738001926 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1266738001927 catalytic core [active] 1266738001928 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1266738001929 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1266738001930 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738001931 Walker A/P-loop; other site 1266738001932 ATP binding site [chemical binding]; other site 1266738001933 Q-loop/lid; other site 1266738001934 ABC transporter signature motif; other site 1266738001935 Walker B; other site 1266738001936 D-loop; other site 1266738001937 H-loop/switch region; other site 1266738001938 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738001939 Walker A/P-loop; other site 1266738001940 ATP binding site [chemical binding]; other site 1266738001941 Q-loop/lid; other site 1266738001942 ABC transporter signature motif; other site 1266738001943 Walker B; other site 1266738001944 D-loop; other site 1266738001945 H-loop/switch region; other site 1266738001946 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1266738001947 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1266738001948 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1266738001949 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1266738001950 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 1266738001951 Protein of unknown function (DUF1436); Region: DUF1436; pfam07262 1266738001952 Protein of unknown function (DUF1436); Region: DUF1436; pfam07262 1266738001953 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1266738001954 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1266738001955 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1266738001956 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1266738001957 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1266738001958 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1266738001959 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1266738001960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738001961 dimer interface [polypeptide binding]; other site 1266738001962 conserved gate region; other site 1266738001963 putative PBP binding loops; other site 1266738001964 ABC-ATPase subunit interface; other site 1266738001965 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1266738001966 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1266738001967 active site 1266738001968 motif I; other site 1266738001969 motif II; other site 1266738001970 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1266738001971 6-phosphogluconolactonase; Provisional; Region: PRK11028 1266738001972 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1266738001973 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1266738001974 inhibitor-cofactor binding pocket; inhibition site 1266738001975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738001976 catalytic residue [active] 1266738001977 biotin synthase; Provisional; Region: PRK15108 1266738001978 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1266738001979 FeS/SAM binding site; other site 1266738001980 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1266738001981 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1266738001982 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1266738001983 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1266738001984 catalytic residue [active] 1266738001985 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1266738001986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738001987 S-adenosylmethionine binding site [chemical binding]; other site 1266738001988 AAA domain; Region: AAA_26; pfam13500 1266738001989 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1266738001990 excinuclease ABC subunit B; Provisional; Region: PRK05298 1266738001991 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1266738001992 ATP binding site [chemical binding]; other site 1266738001993 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1266738001994 nucleotide binding region [chemical binding]; other site 1266738001995 ATP-binding site [chemical binding]; other site 1266738001996 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1266738001997 UvrB/uvrC motif; Region: UVR; pfam02151 1266738001998 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1266738001999 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1266738002000 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1266738002001 phosphate binding site [ion binding]; other site 1266738002002 putative substrate binding pocket [chemical binding]; other site 1266738002003 dimer interface [polypeptide binding]; other site 1266738002004 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1266738002005 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1266738002006 FeS/SAM binding site; other site 1266738002007 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1266738002008 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1266738002009 trimer interface [polypeptide binding]; other site 1266738002010 dimer interface [polypeptide binding]; other site 1266738002011 putative active site [active] 1266738002012 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1266738002013 MoaE interaction surface [polypeptide binding]; other site 1266738002014 MoeB interaction surface [polypeptide binding]; other site 1266738002015 thiocarboxylated glycine; other site 1266738002016 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1266738002017 MoaE homodimer interface [polypeptide binding]; other site 1266738002018 MoaD interaction [polypeptide binding]; other site 1266738002019 active site residues [active] 1266738002020 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1266738002021 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1266738002022 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1266738002023 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1266738002024 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1266738002025 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1266738002026 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1266738002027 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1266738002028 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1266738002029 Walker A/P-loop; other site 1266738002030 ATP binding site [chemical binding]; other site 1266738002031 Q-loop/lid; other site 1266738002032 ABC transporter signature motif; other site 1266738002033 Walker B; other site 1266738002034 D-loop; other site 1266738002035 H-loop/switch region; other site 1266738002036 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1266738002037 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1266738002038 Walker A/P-loop; other site 1266738002039 ATP binding site [chemical binding]; other site 1266738002040 Q-loop/lid; other site 1266738002041 ABC transporter signature motif; other site 1266738002042 Walker B; other site 1266738002043 D-loop; other site 1266738002044 H-loop/switch region; other site 1266738002045 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1266738002046 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1266738002047 HlyD family secretion protein; Region: HlyD_3; pfam13437 1266738002048 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1266738002049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1266738002050 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1266738002051 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1266738002052 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1266738002053 ATP binding site [chemical binding]; other site 1266738002054 Mg++ binding site [ion binding]; other site 1266738002055 motif III; other site 1266738002056 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1266738002057 nucleotide binding region [chemical binding]; other site 1266738002058 ATP-binding site [chemical binding]; other site 1266738002059 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1266738002060 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1266738002061 FMN binding site [chemical binding]; other site 1266738002062 active site 1266738002063 catalytic residues [active] 1266738002064 substrate binding site [chemical binding]; other site 1266738002065 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1266738002066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1266738002067 Coenzyme A binding pocket [chemical binding]; other site 1266738002068 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 1266738002069 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1266738002070 active site residue [active] 1266738002071 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1266738002072 active site residue [active] 1266738002073 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1266738002074 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1266738002075 DEAD_2; Region: DEAD_2; pfam06733 1266738002076 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1266738002077 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1266738002078 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1266738002079 dimerization interface [polypeptide binding]; other site 1266738002080 DPS ferroxidase diiron center [ion binding]; other site 1266738002081 ion pore; other site 1266738002082 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1266738002083 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1266738002084 Coenzyme A binding pocket [chemical binding]; other site 1266738002085 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1266738002086 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1266738002087 active site 1266738002088 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1266738002089 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1266738002090 ATP binding site [chemical binding]; other site 1266738002091 substrate interface [chemical binding]; other site 1266738002092 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1266738002093 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1266738002094 dimer interface [polypeptide binding]; other site 1266738002095 putative functional site; other site 1266738002096 putative MPT binding site; other site 1266738002097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738002098 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1266738002099 putative substrate translocation pore; other site 1266738002100 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1266738002101 active site 1266738002102 hypothetical protein; Provisional; Region: PRK10835 1266738002103 Predicted membrane protein [Function unknown]; Region: COG2311 1266738002104 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1266738002105 putative active site [active] 1266738002106 malate dehydrogenase; Provisional; Region: PRK13529 1266738002107 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1266738002108 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1266738002109 NAD(P) binding site [chemical binding]; other site 1266738002110 cytidine deaminase; Provisional; Region: PRK09027 1266738002111 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1266738002112 active site 1266738002113 catalytic motif [active] 1266738002114 Zn binding site [ion binding]; other site 1266738002115 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1266738002116 active site 1266738002117 catalytic motif [active] 1266738002118 Zn binding site [ion binding]; other site 1266738002119 hypothetical protein; Provisional; Region: PRK10711 1266738002120 hypothetical protein; Provisional; Region: PRK01821 1266738002121 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1266738002122 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1266738002123 active site 1266738002124 HIGH motif; other site 1266738002125 KMSKS motif; other site 1266738002126 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1266738002127 tRNA binding surface [nucleotide binding]; other site 1266738002128 anticodon binding site; other site 1266738002129 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1266738002130 dimer interface [polypeptide binding]; other site 1266738002131 putative tRNA-binding site [nucleotide binding]; other site 1266738002132 antiporter inner membrane protein; Provisional; Region: PRK11670 1266738002133 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1266738002134 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1266738002135 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1266738002136 ATP-binding site [chemical binding]; other site 1266738002137 Sugar specificity; other site 1266738002138 Pyrimidine base specificity; other site 1266738002139 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1266738002140 trimer interface [polypeptide binding]; other site 1266738002141 active site 1266738002142 putative assembly protein; Provisional; Region: PRK10833 1266738002143 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1266738002144 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1266738002145 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1266738002146 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1266738002147 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1266738002148 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1266738002149 Transporter associated domain; Region: CorC_HlyC; smart01091 1266738002150 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1266738002151 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1266738002152 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1266738002153 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 1266738002154 putative deacylase active site [active] 1266738002155 putative alcohol dehydrogenase; Provisional; Region: PRK09860 1266738002156 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1266738002157 dimer interface [polypeptide binding]; other site 1266738002158 active site 1266738002159 metal binding site [ion binding]; metal-binding site 1266738002160 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1266738002161 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1266738002162 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1266738002163 metal binding site [ion binding]; metal-binding site 1266738002164 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1266738002165 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1266738002166 substrate binding site [chemical binding]; other site 1266738002167 glutamase interaction surface [polypeptide binding]; other site 1266738002168 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1266738002169 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1266738002170 catalytic residues [active] 1266738002171 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1266738002172 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1266738002173 putative active site [active] 1266738002174 oxyanion strand; other site 1266738002175 catalytic triad [active] 1266738002176 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1266738002177 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1266738002178 active site 1266738002179 motif I; other site 1266738002180 motif II; other site 1266738002181 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1266738002182 putative active site pocket [active] 1266738002183 4-fold oligomerization interface [polypeptide binding]; other site 1266738002184 metal binding residues [ion binding]; metal-binding site 1266738002185 3-fold/trimer interface [polypeptide binding]; other site 1266738002186 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1266738002187 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1266738002188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738002189 homodimer interface [polypeptide binding]; other site 1266738002190 catalytic residue [active] 1266738002191 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1266738002192 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1266738002193 NAD binding site [chemical binding]; other site 1266738002194 dimerization interface [polypeptide binding]; other site 1266738002195 product binding site; other site 1266738002196 substrate binding site [chemical binding]; other site 1266738002197 zinc binding site [ion binding]; other site 1266738002198 catalytic residues [active] 1266738002199 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1266738002200 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1266738002201 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1266738002202 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1266738002203 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1266738002204 putative NAD(P) binding site [chemical binding]; other site 1266738002205 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1266738002206 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1266738002207 putative C-terminal domain interface [polypeptide binding]; other site 1266738002208 putative GSH binding site (G-site) [chemical binding]; other site 1266738002209 putative dimer interface [polypeptide binding]; other site 1266738002210 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1266738002211 putative N-terminal domain interface [polypeptide binding]; other site 1266738002212 putative dimer interface [polypeptide binding]; other site 1266738002213 putative substrate binding pocket (H-site) [chemical binding]; other site 1266738002214 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 1266738002215 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1266738002216 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1266738002217 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1266738002218 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1266738002219 Potassium binding sites [ion binding]; other site 1266738002220 Cesium cation binding sites [ion binding]; other site 1266738002221 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1266738002222 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1266738002223 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1266738002224 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1266738002225 serine transporter; Region: stp; TIGR00814 1266738002226 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1266738002227 active site 1266738002228 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1266738002229 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 1266738002230 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1266738002231 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1266738002232 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1266738002233 GSH binding site [chemical binding]; other site 1266738002234 catalytic residues [active] 1266738002235 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1266738002236 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 1266738002237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738002238 S-adenosylmethionine binding site [chemical binding]; other site 1266738002239 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1266738002240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738002241 dimer interface [polypeptide binding]; other site 1266738002242 conserved gate region; other site 1266738002243 putative PBP binding loops; other site 1266738002244 ABC-ATPase subunit interface; other site 1266738002245 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1266738002246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738002247 dimer interface [polypeptide binding]; other site 1266738002248 conserved gate region; other site 1266738002249 putative PBP binding loops; other site 1266738002250 ABC-ATPase subunit interface; other site 1266738002251 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1266738002252 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1266738002253 substrate binding pocket [chemical binding]; other site 1266738002254 membrane-bound complex binding site; other site 1266738002255 hinge residues; other site 1266738002256 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1266738002257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738002258 Walker A/P-loop; other site 1266738002259 ATP binding site [chemical binding]; other site 1266738002260 Q-loop/lid; other site 1266738002261 ABC transporter signature motif; other site 1266738002262 Walker B; other site 1266738002263 D-loop; other site 1266738002264 H-loop/switch region; other site 1266738002265 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1266738002266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1266738002267 NAD(P) binding site [chemical binding]; other site 1266738002268 active site 1266738002269 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1266738002270 Predicted membrane protein [Function unknown]; Region: COG2431 1266738002271 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1266738002272 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1266738002273 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1266738002274 putative active site [active] 1266738002275 putative metal-binding site [ion binding]; other site 1266738002276 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1266738002277 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1266738002278 HlyD family secretion protein; Region: HlyD_3; pfam13437 1266738002279 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1266738002280 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1266738002281 Walker A/P-loop; other site 1266738002282 ATP binding site [chemical binding]; other site 1266738002283 Q-loop/lid; other site 1266738002284 ABC transporter signature motif; other site 1266738002285 Walker B; other site 1266738002286 D-loop; other site 1266738002287 H-loop/switch region; other site 1266738002288 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1266738002289 FtsX-like permease family; Region: FtsX; pfam02687 1266738002290 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1266738002291 DNA-binding site [nucleotide binding]; DNA binding site 1266738002292 RNA-binding motif; other site 1266738002293 Uncharacterized conserved protein [Function unknown]; Region: COG2127 1266738002294 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1266738002295 rRNA binding site [nucleotide binding]; other site 1266738002296 predicted 30S ribosome binding site; other site 1266738002297 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1266738002298 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1266738002299 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1266738002300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738002301 Walker A/P-loop; other site 1266738002302 ATP binding site [chemical binding]; other site 1266738002303 Q-loop/lid; other site 1266738002304 ABC transporter signature motif; other site 1266738002305 Walker B; other site 1266738002306 D-loop; other site 1266738002307 H-loop/switch region; other site 1266738002308 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1266738002309 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1266738002310 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738002311 Walker A/P-loop; other site 1266738002312 ATP binding site [chemical binding]; other site 1266738002313 Q-loop/lid; other site 1266738002314 ABC transporter signature motif; other site 1266738002315 Walker B; other site 1266738002316 D-loop; other site 1266738002317 H-loop/switch region; other site 1266738002318 thioredoxin reductase; Provisional; Region: PRK10262 1266738002319 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1266738002320 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1266738002321 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1266738002322 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1266738002323 putative DNA binding site [nucleotide binding]; other site 1266738002324 putative Zn2+ binding site [ion binding]; other site 1266738002325 AsnC family; Region: AsnC_trans_reg; pfam01037 1266738002326 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1266738002327 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1266738002328 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1266738002329 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1266738002330 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1266738002331 recombination factor protein RarA; Reviewed; Region: PRK13342 1266738002332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1266738002333 Walker A motif; other site 1266738002334 ATP binding site [chemical binding]; other site 1266738002335 Walker B motif; other site 1266738002336 arginine finger; other site 1266738002337 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1266738002338 seryl-tRNA synthetase; Provisional; Region: PRK05431 1266738002339 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1266738002340 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1266738002341 dimer interface [polypeptide binding]; other site 1266738002342 active site 1266738002343 motif 1; other site 1266738002344 motif 2; other site 1266738002345 motif 3; other site 1266738002346 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 1266738002347 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1266738002348 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1266738002349 FeS/SAM binding site; other site 1266738002350 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1266738002351 Pyruvate formate lyase 1; Region: PFL1; cd01678 1266738002352 coenzyme A binding site [chemical binding]; other site 1266738002353 active site 1266738002354 catalytic residues [active] 1266738002355 glycine loop; other site 1266738002356 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1266738002357 uncharacterized domain; Region: TIGR00702 1266738002358 YcaO-like family; Region: YcaO; pfam02624 1266738002359 L-asparaginase II; Provisional; Region: ansB; PRK11096 1266738002360 homodimer interface [polypeptide binding]; other site 1266738002361 active site 1266738002362 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1266738002363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738002364 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1266738002365 putative substrate translocation pore; other site 1266738002366 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1266738002367 homodimer interface [polypeptide binding]; other site 1266738002368 substrate-cofactor binding pocket; other site 1266738002369 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738002370 catalytic residue [active] 1266738002371 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1266738002372 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1266738002373 hinge; other site 1266738002374 active site 1266738002375 cytidylate kinase; Provisional; Region: cmk; PRK00023 1266738002376 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1266738002377 CMP-binding site; other site 1266738002378 The sites determining sugar specificity; other site 1266738002379 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1266738002380 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1266738002381 RNA binding site [nucleotide binding]; other site 1266738002382 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1266738002383 RNA binding site [nucleotide binding]; other site 1266738002384 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1266738002385 RNA binding site [nucleotide binding]; other site 1266738002386 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1266738002387 RNA binding site [nucleotide binding]; other site 1266738002388 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1266738002389 RNA binding site [nucleotide binding]; other site 1266738002390 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1266738002391 RNA binding site [nucleotide binding]; other site 1266738002392 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1266738002393 IHF dimer interface [polypeptide binding]; other site 1266738002394 IHF - DNA interface [nucleotide binding]; other site 1266738002395 ComEC family competence protein; Provisional; Region: PRK11539 1266738002396 Competence protein; Region: Competence; pfam03772 1266738002397 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1266738002398 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1266738002399 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1266738002400 Trm112p-like protein; Region: Trm112p; cl01066 1266738002401 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1266738002402 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1266738002403 Ligand binding site; other site 1266738002404 oligomer interface; other site 1266738002405 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1266738002406 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1266738002407 putative active site [active] 1266738002408 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1266738002409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738002410 S-adenosylmethionine binding site [chemical binding]; other site 1266738002411 condesin subunit F; Provisional; Region: PRK05260 1266738002412 condesin subunit E; Provisional; Region: PRK05256 1266738002413 cell division protein MukB; Provisional; Region: mukB; PRK04863 1266738002414 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1266738002415 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 1266738002416 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1266738002417 chloramphenicol acetyltransferase; Provisional; Region: PRK13757 1266738002418 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 1266738002419 acid phosphatase/phosphotransferase; Provisional; Region: aphA; PRK11009 1266738002420 murein L,D-transpeptidase; Provisional; Region: PRK10594 1266738002421 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1266738002422 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1266738002423 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1266738002424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1266738002425 Peptidase M15; Region: Peptidase_M15_3; cl01194 1266738002426 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1266738002427 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1266738002428 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1266738002429 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 1266738002430 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 1266738002431 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1266738002432 ImpA domain protein; Region: DUF3702; pfam12486 1266738002433 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1266738002434 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1266738002435 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1266738002436 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1266738002437 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 1266738002438 Protein of unknown function (DUF3121); Region: DUF3121; pfam11319 1266738002439 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1266738002440 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1266738002441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1266738002442 Walker A motif; other site 1266738002443 ATP binding site [chemical binding]; other site 1266738002444 Walker B motif; other site 1266738002445 arginine finger; other site 1266738002446 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1266738002447 Walker A motif; other site 1266738002448 ATP binding site [chemical binding]; other site 1266738002449 Walker B motif; other site 1266738002450 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1266738002451 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 1266738002452 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 1266738002453 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1266738002454 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 1266738002455 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 1266738002456 FHA domain; Region: FHA; pfam00498 1266738002457 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 1266738002458 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1266738002459 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1266738002460 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1266738002461 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1266738002462 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1266738002463 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1266738002464 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1266738002465 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1266738002466 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1266738002467 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1266738002468 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 1266738002469 PAAR motif; Region: PAAR_motif; pfam05488 1266738002470 RHS Repeat; Region: RHS_repeat; pfam05593 1266738002471 RHS Repeat; Region: RHS_repeat; cl11982 1266738002472 RHS Repeat; Region: RHS_repeat; pfam05593 1266738002473 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1266738002474 RHS Repeat; Region: RHS_repeat; pfam05593 1266738002475 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1266738002476 RHS protein; Region: RHS; pfam03527 1266738002477 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1266738002478 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1266738002479 RHS protein; Region: RHS; pfam03527 1266738002480 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1266738002481 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1266738002482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738002483 homodimer interface [polypeptide binding]; other site 1266738002484 catalytic residue [active] 1266738002485 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1266738002486 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1266738002487 putative dimer interface [polypeptide binding]; other site 1266738002488 putative anticodon binding site; other site 1266738002489 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1266738002490 homodimer interface [polypeptide binding]; other site 1266738002491 motif 1; other site 1266738002492 motif 2; other site 1266738002493 active site 1266738002494 motif 3; other site 1266738002495 aminopeptidase N; Provisional; Region: pepN; PRK14015 1266738002496 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1266738002497 active site 1266738002498 Zn binding site [ion binding]; other site 1266738002499 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1266738002500 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1266738002501 quinone interaction residues [chemical binding]; other site 1266738002502 active site 1266738002503 catalytic residues [active] 1266738002504 FMN binding site [chemical binding]; other site 1266738002505 substrate binding site [chemical binding]; other site 1266738002506 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1266738002507 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1266738002508 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1266738002509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1266738002510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738002511 S-adenosylmethionine binding site [chemical binding]; other site 1266738002512 ABC transporter ATPase component; Reviewed; Region: PRK11147 1266738002513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738002514 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738002515 Walker A/P-loop; other site 1266738002516 Walker A/P-loop; other site 1266738002517 ATP binding site [chemical binding]; other site 1266738002518 ATP binding site [chemical binding]; other site 1266738002519 Q-loop/lid; other site 1266738002520 Q-loop/lid; other site 1266738002521 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1266738002522 ABC transporter signature motif; other site 1266738002523 Walker B; other site 1266738002524 D-loop; other site 1266738002525 ABC transporter; Region: ABC_tran_2; pfam12848 1266738002526 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1266738002527 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 1266738002528 Paraquat-inducible protein A; Region: PqiA; pfam04403 1266738002529 Paraquat-inducible protein A; Region: PqiA; pfam04403 1266738002530 paraquat-inducible protein B; Provisional; Region: PRK10807 1266738002531 mce related protein; Region: MCE; pfam02470 1266738002532 mce related protein; Region: MCE; pfam02470 1266738002533 mce related protein; Region: MCE; pfam02470 1266738002534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1266738002535 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1266738002536 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1266738002537 Ribosome modulation factor; Region: RMF; pfam04957 1266738002538 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1266738002539 active site 1 [active] 1266738002540 dimer interface [polypeptide binding]; other site 1266738002541 active site 2 [active] 1266738002542 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1266738002543 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1266738002544 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 1266738002545 outer membrane protein A; Reviewed; Region: PRK10808 1266738002546 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1266738002547 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1266738002548 ligand binding site [chemical binding]; other site 1266738002549 SOS cell division inhibitor; Provisional; Region: PRK10595 1266738002550 TIGR01666 family membrane protein; Region: YCCS 1266738002551 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1266738002552 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1266738002553 DNA helicase IV; Provisional; Region: helD; PRK11054 1266738002554 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 1266738002555 Part of AAA domain; Region: AAA_19; pfam13245 1266738002556 Family description; Region: UvrD_C_2; pfam13538 1266738002557 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1266738002558 active site 1266738002559 dimer interfaces [polypeptide binding]; other site 1266738002560 catalytic residues [active] 1266738002561 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1266738002562 heat shock protein HspQ; Provisional; Region: PRK14129 1266738002563 Acylphosphatase; Region: Acylphosphatase; pfam00708 1266738002564 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1266738002565 DsrC like protein; Region: DsrC; pfam04358 1266738002566 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1266738002567 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1266738002568 Coenzyme A binding pocket [chemical binding]; other site 1266738002569 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 1266738002570 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 1266738002571 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1266738002572 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1266738002573 HSP70 interaction site [polypeptide binding]; other site 1266738002574 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1266738002575 substrate binding site [polypeptide binding]; other site 1266738002576 dimer interface [polypeptide binding]; other site 1266738002577 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1266738002578 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1266738002579 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1266738002580 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738002581 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1266738002582 dimerization interface [polypeptide binding]; other site 1266738002583 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1266738002584 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1266738002585 active site 1266738002586 catalytic tetrad [active] 1266738002587 Peptidase family C69; Region: Peptidase_C69; cl17793 1266738002588 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1266738002589 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1266738002590 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1266738002591 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1266738002592 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1266738002593 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1266738002594 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1266738002595 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1266738002596 putative acyl-acceptor binding pocket; other site 1266738002597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738002598 S-adenosylmethionine binding site [chemical binding]; other site 1266738002599 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1266738002600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738002601 S-adenosylmethionine binding site [chemical binding]; other site 1266738002602 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1266738002603 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1266738002604 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1266738002605 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1266738002606 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1266738002607 P-loop; other site 1266738002608 Magnesium ion binding site [ion binding]; other site 1266738002609 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1266738002610 Magnesium ion binding site [ion binding]; other site 1266738002611 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1266738002612 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1266738002613 active site 1266738002614 DNA binding site [nucleotide binding] 1266738002615 Int/Topo IB signature motif; other site 1266738002616 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 1266738002617 exonuclease VIII; Reviewed; Region: PRK09709 1266738002618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738002619 non-specific DNA binding site [nucleotide binding]; other site 1266738002620 salt bridge; other site 1266738002621 sequence-specific DNA binding site [nucleotide binding]; other site 1266738002622 Predicted transcriptional regulator [Transcription]; Region: COG2932 1266738002623 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1266738002624 Catalytic site [active] 1266738002625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738002626 non-specific DNA binding site [nucleotide binding]; other site 1266738002627 salt bridge; other site 1266738002628 sequence-specific DNA binding site [nucleotide binding]; other site 1266738002629 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 1266738002630 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 1266738002631 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1266738002632 Walker A motif; other site 1266738002633 ATP binding site [chemical binding]; other site 1266738002634 Walker B motif; other site 1266738002635 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 1266738002636 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1266738002637 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 1266738002638 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1266738002639 catalytic residues [active] 1266738002640 Terminase small subunit; Region: Terminase_2; pfam03592 1266738002641 large terminase protein; Provisional; Region: 17; PHA02533 1266738002642 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 1266738002643 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 1266738002644 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1266738002645 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 1266738002646 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 1266738002647 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 1266738002648 hypothetical protein; Region: PHA02310 1266738002649 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 1266738002650 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1266738002651 Baseplate J-like protein; Region: Baseplate_J; cl01294 1266738002652 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 1266738002653 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1266738002654 hypothetical protein; Provisional; Region: PRK13689 1266738002655 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1266738002656 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1266738002657 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1266738002658 5S rRNA interface [nucleotide binding]; other site 1266738002659 CTC domain interface [polypeptide binding]; other site 1266738002660 L16 interface [polypeptide binding]; other site 1266738002661 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1266738002662 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1266738002663 ATP binding site [chemical binding]; other site 1266738002664 putative Mg++ binding site [ion binding]; other site 1266738002665 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1266738002666 nucleotide binding region [chemical binding]; other site 1266738002667 ATP-binding site [chemical binding]; other site 1266738002668 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1266738002669 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1266738002670 RNA binding surface [nucleotide binding]; other site 1266738002671 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1266738002672 active site 1266738002673 uracil binding [chemical binding]; other site 1266738002674 hypothetical protein; Provisional; Region: PRK11835 1266738002675 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1266738002676 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1266738002677 active site 1266738002678 elongation factor P; Provisional; Region: PRK04542 1266738002679 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1266738002680 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1266738002681 RNA binding site [nucleotide binding]; other site 1266738002682 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1266738002683 RNA binding site [nucleotide binding]; other site 1266738002684 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1266738002685 aromatic amino acid transport protein; Region: araaP; TIGR00837 1266738002686 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1266738002687 nudix motif; other site 1266738002688 endonuclease IV; Provisional; Region: PRK01060 1266738002689 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1266738002690 AP (apurinic/apyrimidinic) site pocket; other site 1266738002691 DNA interaction; other site 1266738002692 Metal-binding active site; metal-binding site 1266738002693 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1266738002694 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1266738002695 Probable transposase; Region: OrfB_IS605; pfam01385 1266738002696 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1266738002697 Predicted membrane protein [Function unknown]; Region: COG2855 1266738002698 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1266738002699 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738002700 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1266738002701 putative dimerization interface [polypeptide binding]; other site 1266738002702 lysine transporter; Provisional; Region: PRK10836 1266738002703 putative outer membrane receptor; Provisional; Region: PRK13513 1266738002704 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1266738002705 N-terminal plug; other site 1266738002706 ligand-binding site [chemical binding]; other site 1266738002707 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1266738002708 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1266738002709 active site 1266738002710 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1266738002711 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1266738002712 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1266738002713 Autotransporter beta-domain; Region: Autotransporter; smart00869 1266738002714 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1266738002715 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1266738002716 dimer interface [polypeptide binding]; other site 1266738002717 PYR/PP interface [polypeptide binding]; other site 1266738002718 TPP binding site [chemical binding]; other site 1266738002719 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1266738002720 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1266738002721 TPP-binding site [chemical binding]; other site 1266738002722 dimer interface [polypeptide binding]; other site 1266738002723 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1266738002724 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738002725 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1266738002726 dimerization interface [polypeptide binding]; other site 1266738002727 D-lactate dehydrogenase; Provisional; Region: PRK11183 1266738002728 FAD binding domain; Region: FAD_binding_4; pfam01565 1266738002729 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1266738002730 exonuclease I; Provisional; Region: sbcB; PRK11779 1266738002731 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1266738002732 active site 1266738002733 substrate binding site [chemical binding]; other site 1266738002734 catalytic site [active] 1266738002735 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1266738002736 galactoside permease; Reviewed; Region: lacY; PRK09528 1266738002737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738002738 putative substrate translocation pore; other site 1266738002739 hypothetical protein; Provisional; Region: PRK05423 1266738002740 ribonuclease E; Reviewed; Region: rne; PRK10811 1266738002741 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1266738002742 homodimer interface [polypeptide binding]; other site 1266738002743 oligonucleotide binding site [chemical binding]; other site 1266738002744 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 1266738002745 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1266738002746 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1266738002747 RNA binding surface [nucleotide binding]; other site 1266738002748 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1266738002749 active site 1266738002750 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1266738002751 active site 1266738002752 dimer interface [polypeptide binding]; other site 1266738002753 hypothetical protein; Provisional; Region: PRK11193 1266738002754 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1266738002755 putative phosphate acyltransferase; Provisional; Region: PRK05331 1266738002756 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1266738002757 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1266738002758 dimer interface [polypeptide binding]; other site 1266738002759 active site 1266738002760 CoA binding pocket [chemical binding]; other site 1266738002761 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1266738002762 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1266738002763 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1266738002764 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1266738002765 NAD(P) binding site [chemical binding]; other site 1266738002766 homotetramer interface [polypeptide binding]; other site 1266738002767 homodimer interface [polypeptide binding]; other site 1266738002768 active site 1266738002769 acyl carrier protein; Provisional; Region: acpP; PRK00982 1266738002770 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1266738002771 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1266738002772 dimer interface [polypeptide binding]; other site 1266738002773 active site 1266738002774 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1266738002775 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1266738002776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738002777 catalytic residue [active] 1266738002778 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1266738002779 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1266738002780 dimerization interface [polypeptide binding]; other site 1266738002781 thymidylate kinase; Validated; Region: tmk; PRK00698 1266738002782 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1266738002783 TMP-binding site; other site 1266738002784 ATP-binding site [chemical binding]; other site 1266738002785 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1266738002786 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1266738002787 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1266738002788 active site 1266738002789 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1266738002790 nucleotide binding site/active site [active] 1266738002791 HIT family signature motif; other site 1266738002792 catalytic residue [active] 1266738002793 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 1266738002794 thiamine kinase; Region: ycfN_thiK; TIGR02721 1266738002795 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1266738002796 active site 1266738002797 substrate binding site [chemical binding]; other site 1266738002798 ATP binding site [chemical binding]; other site 1266738002799 beta-hexosaminidase; Provisional; Region: PRK05337 1266738002800 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1266738002801 hypothetical protein; Provisional; Region: PRK04940 1266738002802 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1266738002803 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1266738002804 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1266738002805 transcription-repair coupling factor; Provisional; Region: PRK10689 1266738002806 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1266738002807 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1266738002808 ATP binding site [chemical binding]; other site 1266738002809 putative Mg++ binding site [ion binding]; other site 1266738002810 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1266738002811 nucleotide binding region [chemical binding]; other site 1266738002812 ATP-binding site [chemical binding]; other site 1266738002813 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1266738002814 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1266738002815 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1266738002816 FtsX-like permease family; Region: FtsX; pfam02687 1266738002817 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1266738002818 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1266738002819 Walker A/P-loop; other site 1266738002820 ATP binding site [chemical binding]; other site 1266738002821 Q-loop/lid; other site 1266738002822 ABC transporter signature motif; other site 1266738002823 Walker B; other site 1266738002824 D-loop; other site 1266738002825 H-loop/switch region; other site 1266738002826 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1266738002827 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1266738002828 FtsX-like permease family; Region: FtsX; pfam02687 1266738002829 NAD-dependent deacetylase; Provisional; Region: PRK00481 1266738002830 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1266738002831 NAD+ binding site [chemical binding]; other site 1266738002832 substrate binding site [chemical binding]; other site 1266738002833 Zn binding site [ion binding]; other site 1266738002834 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1266738002835 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1266738002836 metal binding site [ion binding]; metal-binding site 1266738002837 dimer interface [polypeptide binding]; other site 1266738002838 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1266738002839 sensor protein PhoQ; Provisional; Region: PRK10815 1266738002840 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1266738002841 HAMP domain; Region: HAMP; pfam00672 1266738002842 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1266738002843 dimer interface [polypeptide binding]; other site 1266738002844 phosphorylation site [posttranslational modification] 1266738002845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1266738002846 ATP binding site [chemical binding]; other site 1266738002847 Mg2+ binding site [ion binding]; other site 1266738002848 G-X-G motif; other site 1266738002849 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1266738002850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738002851 active site 1266738002852 phosphorylation site [posttranslational modification] 1266738002853 intermolecular recognition site; other site 1266738002854 dimerization interface [polypeptide binding]; other site 1266738002855 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1266738002856 DNA binding site [nucleotide binding] 1266738002857 adenylosuccinate lyase; Provisional; Region: PRK09285 1266738002858 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1266738002859 tetramer interface [polypeptide binding]; other site 1266738002860 active site 1266738002861 putative lysogenization regulator; Reviewed; Region: PRK00218 1266738002862 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1266738002863 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1266738002864 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1266738002865 nudix motif; other site 1266738002866 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 1266738002867 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1266738002868 active site 1266738002869 isocitrate dehydrogenase; Validated; Region: PRK07362 1266738002870 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1266738002871 Transposase; Region: HTH_Tnp_1; cl17663 1266738002872 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1266738002873 Secretory lipase; Region: LIP; pfam03583 1266738002874 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1266738002875 DNA-binding site [nucleotide binding]; DNA binding site 1266738002876 RNA-binding motif; other site 1266738002877 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1266738002878 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1266738002879 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1266738002880 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1266738002881 NADP binding site [chemical binding]; other site 1266738002882 hypothetical protein; Provisional; Region: PRK08233 1266738002883 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1266738002884 active site 1266738002885 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738002886 non-specific DNA binding site [nucleotide binding]; other site 1266738002887 salt bridge; other site 1266738002888 sequence-specific DNA binding site [nucleotide binding]; other site 1266738002889 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1266738002890 ParB-like nuclease domain; Region: ParBc; pfam02195 1266738002891 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1266738002892 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1266738002893 Active Sites [active] 1266738002894 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1266738002895 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1266738002896 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1266738002897 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1266738002898 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1266738002899 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1266738002900 Protein of unknown function (DUF465); Region: DUF465; cl01070 1266738002901 Predicted ATPase [General function prediction only]; Region: COG3911 1266738002902 AAA domain; Region: AAA_28; pfam13521 1266738002903 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1266738002904 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1266738002905 active site 1266738002906 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 1266738002907 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1266738002908 putative hydrolase; Validated; Region: PRK09248 1266738002909 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1266738002910 active site 1266738002911 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 1266738002912 putative active site [active] 1266738002913 putative metal binding residues [ion binding]; other site 1266738002914 signature motif; other site 1266738002915 putative triphosphate binding site [ion binding]; other site 1266738002916 dimer interface [polypeptide binding]; other site 1266738002917 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1266738002918 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1266738002919 Ligand Binding Site [chemical binding]; other site 1266738002920 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1266738002921 Ferritin-like domain; Region: Ferritin; pfam00210 1266738002922 ferroxidase diiron center [ion binding]; other site 1266738002923 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1266738002924 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1266738002925 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 1266738002926 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1266738002927 mce related protein; Region: MCE; pfam02470 1266738002928 mce related protein; Region: MCE; pfam02470 1266738002929 mce related protein; Region: MCE; pfam02470 1266738002930 mce related protein; Region: MCE; pfam02470 1266738002931 mce related protein; Region: MCE; pfam02470 1266738002932 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1266738002933 GAF domain; Region: GAF_2; pfam13185 1266738002934 ProP expression regulator; Provisional; Region: PRK04950 1266738002935 ProQ/FINO family; Region: ProQ; pfam04352 1266738002936 carboxy-terminal protease; Provisional; Region: PRK11186 1266738002937 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1266738002938 protein binding site [polypeptide binding]; other site 1266738002939 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1266738002940 Catalytic dyad [active] 1266738002941 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1266738002942 outer membrane porin, OprD family; Region: OprD; pfam03573 1266738002943 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1266738002944 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1266738002945 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 1266738002946 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1266738002947 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1266738002948 motif II; other site 1266738002949 YniB-like protein; Region: YniB; pfam14002 1266738002950 Phosphotransferase enzyme family; Region: APH; pfam01636 1266738002951 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1266738002952 active site 1266738002953 substrate binding site [chemical binding]; other site 1266738002954 ATP binding site [chemical binding]; other site 1266738002955 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1266738002956 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1266738002957 ABC-ATPase subunit interface; other site 1266738002958 dimer interface [polypeptide binding]; other site 1266738002959 putative PBP binding regions; other site 1266738002960 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1266738002961 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1266738002962 ABC-ATPase subunit interface; other site 1266738002963 dimer interface [polypeptide binding]; other site 1266738002964 putative PBP binding regions; other site 1266738002965 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 1266738002966 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1266738002967 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1266738002968 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1266738002969 metal binding site [ion binding]; metal-binding site 1266738002970 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1266738002971 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1266738002972 catalytic residue [active] 1266738002973 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 1266738002974 inner membrane protein; Provisional; Region: PRK10995 1266738002975 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1266738002976 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1266738002977 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1266738002978 dimer interface [polypeptide binding]; other site 1266738002979 putative tRNA-binding site [nucleotide binding]; other site 1266738002980 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1266738002981 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1266738002982 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 1266738002983 mannosyl binding site [chemical binding]; other site 1266738002984 Fimbrial protein; Region: Fimbrial; pfam00419 1266738002985 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1266738002986 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1266738002987 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1266738002988 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1266738002989 active site 1266738002990 dimer interface [polypeptide binding]; other site 1266738002991 motif 1; other site 1266738002992 motif 2; other site 1266738002993 motif 3; other site 1266738002994 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1266738002995 anticodon binding site; other site 1266738002996 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1266738002997 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1266738002998 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1266738002999 23S rRNA binding site [nucleotide binding]; other site 1266738003000 L21 binding site [polypeptide binding]; other site 1266738003001 L13 binding site [polypeptide binding]; other site 1266738003002 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1266738003003 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1266738003004 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1266738003005 dimer interface [polypeptide binding]; other site 1266738003006 motif 1; other site 1266738003007 active site 1266738003008 motif 2; other site 1266738003009 motif 3; other site 1266738003010 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1266738003011 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1266738003012 putative tRNA-binding site [nucleotide binding]; other site 1266738003013 B3/4 domain; Region: B3_4; pfam03483 1266738003014 tRNA synthetase B5 domain; Region: B5; smart00874 1266738003015 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1266738003016 dimer interface [polypeptide binding]; other site 1266738003017 motif 1; other site 1266738003018 motif 3; other site 1266738003019 motif 2; other site 1266738003020 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1266738003021 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1266738003022 IHF dimer interface [polypeptide binding]; other site 1266738003023 IHF - DNA interface [nucleotide binding]; other site 1266738003024 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1266738003025 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1266738003026 ABC-ATPase subunit interface; other site 1266738003027 dimer interface [polypeptide binding]; other site 1266738003028 putative PBP binding regions; other site 1266738003029 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 1266738003030 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1266738003031 Walker A/P-loop; other site 1266738003032 ATP binding site [chemical binding]; other site 1266738003033 Q-loop/lid; other site 1266738003034 ABC transporter signature motif; other site 1266738003035 Walker B; other site 1266738003036 D-loop; other site 1266738003037 H-loop/switch region; other site 1266738003038 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1266738003039 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1266738003040 inhibitor-cofactor binding pocket; inhibition site 1266738003041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738003042 catalytic residue [active] 1266738003043 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1266738003044 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1266738003045 Ligand binding site; other site 1266738003046 Putative Catalytic site; other site 1266738003047 DXD motif; other site 1266738003048 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1266738003049 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1266738003050 active site 1266738003051 substrate binding site [chemical binding]; other site 1266738003052 cosubstrate binding site; other site 1266738003053 catalytic site [active] 1266738003054 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1266738003055 active site 1266738003056 hexamer interface [polypeptide binding]; other site 1266738003057 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1266738003058 NAD binding site [chemical binding]; other site 1266738003059 substrate binding site [chemical binding]; other site 1266738003060 active site 1266738003061 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1266738003062 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 1266738003063 putative active site [active] 1266738003064 putative catalytic site [active] 1266738003065 putative Zn binding site [ion binding]; other site 1266738003066 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1266738003067 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1266738003068 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1266738003069 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1266738003070 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1266738003071 NlpC/P60 family; Region: NLPC_P60; pfam00877 1266738003072 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1266738003073 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1266738003074 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1266738003075 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1266738003076 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1266738003077 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1266738003078 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1266738003079 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1266738003080 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1266738003081 DNA-binding site [nucleotide binding]; DNA binding site 1266738003082 FCD domain; Region: FCD; pfam07729 1266738003083 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 1266738003084 DctM-like transporters; Region: DctM; pfam06808 1266738003085 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1266738003086 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1266738003087 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1266738003088 acetolactate synthase; Reviewed; Region: PRK08617 1266738003089 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1266738003090 PYR/PP interface [polypeptide binding]; other site 1266738003091 dimer interface [polypeptide binding]; other site 1266738003092 TPP binding site [chemical binding]; other site 1266738003093 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1266738003094 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1266738003095 TPP-binding site [chemical binding]; other site 1266738003096 dimer interface [polypeptide binding]; other site 1266738003097 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1266738003098 fimbrial protein PefA; Provisional; Region: PRK15214 1266738003099 fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213 1266738003100 PapC N-terminal domain; Region: PapC_N; pfam13954 1266738003101 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1266738003102 PapC C-terminal domain; Region: PapC_C; pfam13953 1266738003103 fimbrial chaperone protein PefD; Provisional; Region: PRK15211 1266738003104 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1266738003105 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1266738003106 Fimbrial protein; Region: Fimbrial; pfam00419 1266738003107 Fimbrial protein; Region: Fimbrial; pfam00419 1266738003108 Fimbrial protein; Region: Fimbrial; pfam00419 1266738003109 RHS protein; Region: RHS; pfam03527 1266738003110 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1266738003111 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1266738003112 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1266738003113 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1266738003114 PAAR motif; Region: PAAR_motif; pfam05488 1266738003115 RHS Repeat; Region: RHS_repeat; cl11982 1266738003116 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1266738003117 RHS Repeat; Region: RHS_repeat; pfam05593 1266738003118 RHS Repeat; Region: RHS_repeat; cl11982 1266738003119 RHS protein; Region: RHS; pfam03527 1266738003120 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 1266738003121 GTP-binding protein YchF; Reviewed; Region: PRK09601 1266738003122 YchF GTPase; Region: YchF; cd01900 1266738003123 G1 box; other site 1266738003124 GTP/Mg2+ binding site [chemical binding]; other site 1266738003125 Switch I region; other site 1266738003126 G2 box; other site 1266738003127 Switch II region; other site 1266738003128 G3 box; other site 1266738003129 G4 box; other site 1266738003130 G5 box; other site 1266738003131 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1266738003132 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1266738003133 putative active site [active] 1266738003134 catalytic residue [active] 1266738003135 hypothetical protein; Provisional; Region: PRK10692 1266738003136 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1266738003137 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1266738003138 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1266738003139 active site 1266738003140 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1266738003141 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1266738003142 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1266738003143 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 1266738003144 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1266738003145 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1266738003146 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1266738003147 tRNA; other site 1266738003148 putative tRNA binding site [nucleotide binding]; other site 1266738003149 putative NADP binding site [chemical binding]; other site 1266738003150 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1266738003151 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1266738003152 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1266738003153 RF-1 domain; Region: RF-1; pfam00472 1266738003154 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1266738003155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738003156 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1266738003157 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1266738003158 radical SAM protein, TIGR01212 family; Region: TIGR01212 1266738003159 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1266738003160 FeS/SAM binding site; other site 1266738003161 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 1266738003162 putative transporter; Provisional; Region: PRK11660 1266738003163 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1266738003164 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1266738003165 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1266738003166 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1266738003167 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1266738003168 putative ligand binding site [chemical binding]; other site 1266738003169 NAD binding site [chemical binding]; other site 1266738003170 dimerization interface [polypeptide binding]; other site 1266738003171 catalytic site [active] 1266738003172 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 1266738003173 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1266738003174 lipoprotein; Provisional; Region: PRK10598 1266738003175 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1266738003176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738003177 putative substrate translocation pore; other site 1266738003178 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 1266738003179 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1266738003180 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1266738003181 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1266738003182 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1266738003183 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1266738003184 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1266738003185 active site 1266738003186 HIGH motif; other site 1266738003187 KMSK motif region; other site 1266738003188 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1266738003189 tRNA binding surface [nucleotide binding]; other site 1266738003190 anticodon binding site; other site 1266738003191 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1266738003192 putative metal binding site [ion binding]; other site 1266738003193 copper homeostasis protein CutC; Provisional; Region: PRK11572 1266738003194 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1266738003195 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1266738003196 ABC transporter; Region: ABC_tran_2; pfam12848 1266738003197 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1266738003198 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1266738003199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738003200 S-adenosylmethionine binding site [chemical binding]; other site 1266738003201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738003202 S-adenosylmethionine binding site [chemical binding]; other site 1266738003203 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1266738003204 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1266738003205 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1266738003206 dimer interface [polypeptide binding]; other site 1266738003207 anticodon binding site; other site 1266738003208 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1266738003209 homodimer interface [polypeptide binding]; other site 1266738003210 motif 1; other site 1266738003211 active site 1266738003212 motif 2; other site 1266738003213 GAD domain; Region: GAD; pfam02938 1266738003214 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1266738003215 active site 1266738003216 motif 3; other site 1266738003217 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1266738003218 nudix motif; other site 1266738003219 hypothetical protein; Validated; Region: PRK00110 1266738003220 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1266738003221 active site 1266738003222 putative DNA-binding cleft [nucleotide binding]; other site 1266738003223 dimer interface [polypeptide binding]; other site 1266738003224 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1266738003225 RuvA N terminal domain; Region: RuvA_N; pfam01330 1266738003226 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1266738003227 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1266738003228 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1266738003229 Walker A motif; other site 1266738003230 ATP binding site [chemical binding]; other site 1266738003231 Walker B motif; other site 1266738003232 arginine finger; other site 1266738003233 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1266738003234 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1266738003235 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1266738003236 ABC-ATPase subunit interface; other site 1266738003237 dimer interface [polypeptide binding]; other site 1266738003238 putative PBP binding regions; other site 1266738003239 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1266738003240 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1266738003241 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 1266738003242 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1266738003243 metal binding site [ion binding]; metal-binding site 1266738003244 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1266738003245 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1266738003246 putative acyl-acceptor binding pocket; other site 1266738003247 pyruvate kinase; Provisional; Region: PRK05826 1266738003248 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1266738003249 domain interfaces; other site 1266738003250 active site 1266738003251 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1266738003252 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1266738003253 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1266738003254 putative active site [active] 1266738003255 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1266738003256 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1266738003257 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1266738003258 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 1266738003259 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1266738003260 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1266738003261 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1266738003262 NAD(P) binding site [chemical binding]; other site 1266738003263 putative active site [active] 1266738003264 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1266738003265 homotrimer interaction site [polypeptide binding]; other site 1266738003266 putative active site [active] 1266738003267 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1266738003268 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1266738003269 DEAD_2; Region: DEAD_2; pfam06733 1266738003270 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1266738003271 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1266738003272 Glycoprotease family; Region: Peptidase_M22; pfam00814 1266738003273 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 1266738003274 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1266738003275 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1266738003276 acyl-activating enzyme (AAE) consensus motif; other site 1266738003277 putative AMP binding site [chemical binding]; other site 1266738003278 putative active site [active] 1266738003279 putative CoA binding site [chemical binding]; other site 1266738003280 ribonuclease D; Provisional; Region: PRK10829 1266738003281 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1266738003282 catalytic site [active] 1266738003283 putative active site [active] 1266738003284 putative substrate binding site [chemical binding]; other site 1266738003285 HRDC domain; Region: HRDC; pfam00570 1266738003286 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1266738003287 cell division inhibitor MinD; Provisional; Region: PRK10818 1266738003288 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1266738003289 Switch I; other site 1266738003290 Switch II; other site 1266738003291 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1266738003292 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1266738003293 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1266738003294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 1266738003295 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1266738003296 Uncharacterized conserved protein (DUF2042); Region: DUF2042; cl10727 1266738003297 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1266738003298 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1266738003299 catalytic residue [active] 1266738003300 hypothetical protein; Provisional; Region: PRK10691 1266738003301 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1266738003302 hypothetical protein; Provisional; Region: PRK05170 1266738003303 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1266738003304 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1266738003305 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738003306 Walker A/P-loop; other site 1266738003307 ATP binding site [chemical binding]; other site 1266738003308 Q-loop/lid; other site 1266738003309 ABC transporter signature motif; other site 1266738003310 Walker B; other site 1266738003311 D-loop; other site 1266738003312 H-loop/switch region; other site 1266738003313 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1266738003314 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1266738003315 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1266738003316 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1266738003317 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1266738003318 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1266738003319 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1266738003320 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1266738003321 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1266738003322 dimer interface [polypeptide binding]; other site 1266738003323 putative CheW interface [polypeptide binding]; other site 1266738003324 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1266738003325 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1266738003326 putative ligand binding site [chemical binding]; other site 1266738003327 putative NAD binding site [chemical binding]; other site 1266738003328 catalytic site [active] 1266738003329 hypothetical protein; Provisional; Region: PRK10695 1266738003330 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 1266738003331 Fimbrial protein; Region: Fimbrial; pfam00419 1266738003332 PapC N-terminal domain; Region: PapC_N; pfam13954 1266738003333 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1266738003334 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1266738003335 PapC C-terminal domain; Region: PapC_C; pfam13953 1266738003336 putative chaperone protein EcpD; Provisional; Region: PRK09926 1266738003337 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1266738003338 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1266738003339 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1266738003340 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1266738003341 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1266738003342 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1266738003343 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1266738003344 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1266738003345 ATP binding site [chemical binding]; other site 1266738003346 putative Mg++ binding site [ion binding]; other site 1266738003347 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1266738003348 nucleotide binding region [chemical binding]; other site 1266738003349 ATP-binding site [chemical binding]; other site 1266738003350 Helicase associated domain (HA2); Region: HA2; pfam04408 1266738003351 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1266738003352 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1266738003353 Fimbrial protein; Region: Fimbrial; cl01416 1266738003354 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1266738003355 PapC N-terminal domain; Region: PapC_N; pfam13954 1266738003356 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1266738003357 PapC C-terminal domain; Region: PapC_C; pfam13953 1266738003358 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1266738003359 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1266738003360 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1266738003361 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1266738003362 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1266738003363 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1266738003364 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1266738003365 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1266738003366 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1266738003367 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1266738003368 ligand binding site [chemical binding]; other site 1266738003369 homodimer interface [polypeptide binding]; other site 1266738003370 NAD(P) binding site [chemical binding]; other site 1266738003371 trimer interface B [polypeptide binding]; other site 1266738003372 trimer interface A [polypeptide binding]; other site 1266738003373 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1266738003374 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1266738003375 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1266738003376 universal stress protein UspE; Provisional; Region: PRK11175 1266738003377 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1266738003378 Ligand Binding Site [chemical binding]; other site 1266738003379 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1266738003380 Ligand Binding Site [chemical binding]; other site 1266738003381 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1266738003382 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1266738003383 ligand binding site [chemical binding]; other site 1266738003384 flexible hinge region; other site 1266738003385 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1266738003386 putative switch regulator; other site 1266738003387 non-specific DNA interactions [nucleotide binding]; other site 1266738003388 DNA binding site [nucleotide binding] 1266738003389 sequence specific DNA binding site [nucleotide binding]; other site 1266738003390 putative cAMP binding site [chemical binding]; other site 1266738003391 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1266738003392 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1266738003393 putative [Fe4-S4] binding site [ion binding]; other site 1266738003394 putative molybdopterin cofactor binding site [chemical binding]; other site 1266738003395 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1266738003396 putative molybdopterin cofactor binding site; other site 1266738003397 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1266738003398 4Fe-4S binding domain; Region: Fer4; pfam00037 1266738003399 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 1266738003400 4Fe-4S binding domain; Region: Fer4; cl02805 1266738003401 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1266738003402 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1266738003403 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1266738003404 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1266738003405 NAD(P) binding site [chemical binding]; other site 1266738003406 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1266738003407 Predicted transcriptional regulators [Transcription]; Region: COG1695 1266738003408 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1266738003409 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1266738003410 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1266738003411 catalytic residue [active] 1266738003412 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1266738003413 catalytic residues [active] 1266738003414 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1266738003415 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1266738003416 Protein of unknown function DUF262; Region: DUF262; pfam03235 1266738003417 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1266738003418 active site 1266738003419 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1266738003420 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1266738003421 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1266738003422 Coenzyme A binding pocket [chemical binding]; other site 1266738003423 Predicted permeases [General function prediction only]; Region: COG0679 1266738003424 AMP nucleosidase; Provisional; Region: PRK08292 1266738003425 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1266738003426 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1266738003427 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1266738003428 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1266738003429 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1266738003430 active site 1266738003431 DNA binding site [nucleotide binding] 1266738003432 Int/Topo IB signature motif; other site 1266738003433 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1266738003434 catalytic nucleophile [active] 1266738003435 HlyD family secretion protein; Region: HlyD; pfam00529 1266738003436 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1266738003437 HlyD family secretion protein; Region: HlyD_3; pfam13437 1266738003438 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1266738003439 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1266738003440 Walker A/P-loop; other site 1266738003441 ATP binding site [chemical binding]; other site 1266738003442 Q-loop/lid; other site 1266738003443 ABC transporter signature motif; other site 1266738003444 Walker B; other site 1266738003445 D-loop; other site 1266738003446 H-loop/switch region; other site 1266738003447 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1266738003448 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1266738003449 Walker A/P-loop; other site 1266738003450 ATP binding site [chemical binding]; other site 1266738003451 Q-loop/lid; other site 1266738003452 ABC transporter signature motif; other site 1266738003453 Walker B; other site 1266738003454 D-loop; other site 1266738003455 H-loop/switch region; other site 1266738003456 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1266738003457 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1266738003458 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1266738003459 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1266738003460 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1266738003461 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1266738003462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738003463 active site 1266738003464 phosphorylation site [posttranslational modification] 1266738003465 intermolecular recognition site; other site 1266738003466 dimerization interface [polypeptide binding]; other site 1266738003467 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1266738003468 DNA binding site [nucleotide binding] 1266738003469 sensor protein KdpD; Provisional; Region: PRK10490 1266738003470 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1266738003471 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1266738003472 Ligand Binding Site [chemical binding]; other site 1266738003473 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1266738003474 GAF domain; Region: GAF_3; pfam13492 1266738003475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1266738003476 dimer interface [polypeptide binding]; other site 1266738003477 phosphorylation site [posttranslational modification] 1266738003478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1266738003479 ATP binding site [chemical binding]; other site 1266738003480 Mg2+ binding site [ion binding]; other site 1266738003481 G-X-G motif; other site 1266738003482 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1266738003483 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1266738003484 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1266738003485 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1266738003486 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1266738003487 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1266738003488 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1266738003489 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1266738003490 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1266738003491 nucleoside/Zn binding site; other site 1266738003492 dimer interface [polypeptide binding]; other site 1266738003493 catalytic motif [active] 1266738003494 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 1266738003495 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1266738003496 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1266738003497 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1266738003498 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 1266738003499 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1266738003500 putative [Fe4-S4] binding site [ion binding]; other site 1266738003501 putative molybdopterin cofactor binding site [chemical binding]; other site 1266738003502 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1266738003503 putative molybdopterin cofactor binding site; other site 1266738003504 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1266738003505 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1266738003506 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1266738003507 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1266738003508 substrate binding site [chemical binding]; other site 1266738003509 dimer interface [polypeptide binding]; other site 1266738003510 ATP binding site [chemical binding]; other site 1266738003511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1266738003512 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1266738003513 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 1266738003514 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1266738003515 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1266738003516 DAK2 domain; Region: Dak2; pfam02734 1266738003517 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1266738003518 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1266738003519 inhibitor site; inhibition site 1266738003520 active site 1266738003521 dimer interface [polypeptide binding]; other site 1266738003522 catalytic residue [active] 1266738003523 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1266738003524 tetramer interface [polypeptide binding]; other site 1266738003525 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1266738003526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738003527 catalytic residue [active] 1266738003528 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1266738003529 homotrimer interaction site [polypeptide binding]; other site 1266738003530 putative active site [active] 1266738003531 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1266738003532 Coenzyme A binding pocket [chemical binding]; other site 1266738003533 LysE type translocator; Region: LysE; cl00565 1266738003534 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 1266738003535 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1266738003536 endonuclease III; Region: ENDO3c; smart00478 1266738003537 minor groove reading motif; other site 1266738003538 helix-hairpin-helix signature motif; other site 1266738003539 substrate binding pocket [chemical binding]; other site 1266738003540 active site 1266738003541 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1266738003542 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1266738003543 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1266738003544 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1266738003545 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1266738003546 DNA binding site [nucleotide binding] 1266738003547 active site 1266738003548 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 1266738003549 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1266738003550 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1266738003551 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1266738003552 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1266738003553 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1266738003554 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1266738003555 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1266738003556 dimer interface [polypeptide binding]; other site 1266738003557 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1266738003558 metal binding site [ion binding]; metal-binding site 1266738003559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1266738003560 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1266738003561 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1266738003562 methionine gamma-lyase; Validated; Region: PRK07049 1266738003563 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1266738003564 homodimer interface [polypeptide binding]; other site 1266738003565 substrate-cofactor binding pocket; other site 1266738003566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738003567 catalytic residue [active] 1266738003568 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1266738003569 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1266738003570 Helix-turn-helix domain; Region: HTH_18; pfam12833 1266738003571 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1266738003572 putative transporter; Provisional; Region: PRK10054 1266738003573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738003574 putative substrate translocation pore; other site 1266738003575 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1266738003576 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1266738003577 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1266738003578 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738003579 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1266738003580 putative effector binding pocket; other site 1266738003581 dimerization interface [polypeptide binding]; other site 1266738003582 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1266738003583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738003584 putative substrate translocation pore; other site 1266738003585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738003586 putative substrate translocation pore; other site 1266738003587 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1266738003588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1266738003589 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1266738003590 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738003591 Walker A/P-loop; other site 1266738003592 ATP binding site [chemical binding]; other site 1266738003593 Q-loop/lid; other site 1266738003594 ABC transporter signature motif; other site 1266738003595 Walker B; other site 1266738003596 D-loop; other site 1266738003597 H-loop/switch region; other site 1266738003598 ABC transporter; Region: ABC_tran_2; pfam12848 1266738003599 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1266738003600 hypothetical protein; Validated; Region: PRK00124 1266738003601 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 1266738003602 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1266738003603 active site 1266738003604 putative substrate binding pocket [chemical binding]; other site 1266738003605 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1266738003606 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738003607 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1266738003608 substrate binding pocket [chemical binding]; other site 1266738003609 dimerization interface [polypeptide binding]; other site 1266738003610 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 1266738003611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738003612 putative substrate translocation pore; other site 1266738003613 Helix-turn-helix domain; Region: HTH_31; pfam13560 1266738003614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738003615 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1266738003616 putative substrate translocation pore; other site 1266738003617 multidrug resistance protein MdtN; Provisional; Region: PRK10476 1266738003618 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1266738003619 HlyD family secretion protein; Region: HlyD_3; pfam13437 1266738003620 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1266738003621 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1266738003622 putative chaperone; Provisional; Region: PRK11678 1266738003623 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1266738003624 nucleotide binding site [chemical binding]; other site 1266738003625 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1266738003626 SBD interface [polypeptide binding]; other site 1266738003627 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1266738003628 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1266738003629 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1266738003630 catalytic residue [active] 1266738003631 YjbD family (DUF3811); Region: DUF3811; cl08125 1266738003632 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1266738003633 xylulokinase; Provisional; Region: PRK15027 1266738003634 N- and C-terminal domain interface [polypeptide binding]; other site 1266738003635 active site 1266738003636 MgATP binding site [chemical binding]; other site 1266738003637 catalytic site [active] 1266738003638 metal binding site [ion binding]; metal-binding site 1266738003639 xylulose binding site [chemical binding]; other site 1266738003640 homodimer interface [polypeptide binding]; other site 1266738003641 xylose isomerase; Provisional; Region: PRK05474 1266738003642 xylose isomerase; Region: xylose_isom_A; TIGR02630 1266738003643 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1266738003644 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1266738003645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738003646 homodimer interface [polypeptide binding]; other site 1266738003647 catalytic residue [active] 1266738003648 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1266738003649 putative dimerization interface [polypeptide binding]; other site 1266738003650 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1266738003651 putative ligand binding site [chemical binding]; other site 1266738003652 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1266738003653 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1266738003654 Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894 1266738003655 malonic semialdehyde reductase; Provisional; Region: PRK10538 1266738003656 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1266738003657 putative NAD(P) binding site [chemical binding]; other site 1266738003658 homodimer interface [polypeptide binding]; other site 1266738003659 homotetramer interface [polypeptide binding]; other site 1266738003660 active site 1266738003661 hypothetical protein; Provisional; Region: PRK13659 1266738003662 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1266738003663 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1266738003664 AAA domain; Region: AAA_26; pfam13500 1266738003665 MarR family; Region: MarR_2; cl17246 1266738003666 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1266738003667 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1266738003668 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1266738003669 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1266738003670 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738003671 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1266738003672 dimerization interface [polypeptide binding]; other site 1266738003673 substrate binding pocket [chemical binding]; other site 1266738003674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738003675 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1266738003676 putative substrate translocation pore; other site 1266738003677 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 1266738003678 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1266738003679 Class II fumarases; Region: Fumarase_classII; cd01362 1266738003680 active site 1266738003681 tetramer interface [polypeptide binding]; other site 1266738003682 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1266738003683 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1266738003684 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1266738003685 active site 1266738003686 purine riboside binding site [chemical binding]; other site 1266738003687 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1266738003688 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1266738003689 putative oxidoreductase; Provisional; Region: PRK11579 1266738003690 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1266738003691 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1266738003692 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1266738003693 electron transport complex protein RnfB; Provisional; Region: PRK05113 1266738003694 Putative Fe-S cluster; Region: FeS; cl17515 1266738003695 4Fe-4S binding domain; Region: Fer4; pfam00037 1266738003696 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 1266738003697 SLBB domain; Region: SLBB; pfam10531 1266738003698 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1266738003699 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1266738003700 electron transport complex protein RnfG; Validated; Region: PRK01908 1266738003701 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1266738003702 endonuclease III; Region: ENDO3c; smart00478 1266738003703 minor groove reading motif; other site 1266738003704 helix-hairpin-helix signature motif; other site 1266738003705 substrate binding pocket [chemical binding]; other site 1266738003706 active site 1266738003707 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1266738003708 exoribonuclease II; Provisional; Region: PRK05054 1266738003709 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1266738003710 RNB domain; Region: RNB; pfam00773 1266738003711 S1 RNA binding domain; Region: S1; pfam00575 1266738003712 translation initiation factor Sui1; Validated; Region: PRK06824 1266738003713 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1266738003714 putative rRNA binding site [nucleotide binding]; other site 1266738003715 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1266738003716 active site 1266738003717 dimer interface [polypeptide binding]; other site 1266738003718 tetratricopeptide repeat protein; Provisional; Region: PRK11788 1266738003719 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1266738003720 binding surface 1266738003721 TPR motif; other site 1266738003722 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1266738003723 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1266738003724 active site 1266738003725 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1266738003726 dimerization interface [polypeptide binding]; other site 1266738003727 active site 1266738003728 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1266738003729 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 1266738003730 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1266738003731 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1266738003732 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1266738003733 putative trimer interface [polypeptide binding]; other site 1266738003734 putative CoA binding site [chemical binding]; other site 1266738003735 aconitate hydratase; Validated; Region: PRK09277 1266738003736 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1266738003737 substrate binding site [chemical binding]; other site 1266738003738 ligand binding site [chemical binding]; other site 1266738003739 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1266738003740 substrate binding site [chemical binding]; other site 1266738003741 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1266738003742 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738003743 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1266738003744 substrate binding site [chemical binding]; other site 1266738003745 dimerization interface [polypeptide binding]; other site 1266738003746 KxxxW cyclic peptide radical SAM maturase; Region: rSAM_pep_cyc; TIGR04080 1266738003747 Protein of unknown function (DUF796); Region: DUF796; cl01226 1266738003748 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1266738003749 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1266738003750 E-class dimer interface [polypeptide binding]; other site 1266738003751 P-class dimer interface [polypeptide binding]; other site 1266738003752 active site 1266738003753 Cu2+ binding site [ion binding]; other site 1266738003754 Zn2+ binding site [ion binding]; other site 1266738003755 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1266738003756 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1266738003757 active site 1266738003758 interdomain interaction site; other site 1266738003759 putative metal-binding site [ion binding]; other site 1266738003760 nucleotide binding site [chemical binding]; other site 1266738003761 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1266738003762 domain I; other site 1266738003763 DNA binding groove [nucleotide binding] 1266738003764 phosphate binding site [ion binding]; other site 1266738003765 domain II; other site 1266738003766 domain III; other site 1266738003767 nucleotide binding site [chemical binding]; other site 1266738003768 catalytic site [active] 1266738003769 domain IV; other site 1266738003770 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1266738003771 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1266738003772 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1266738003773 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1266738003774 hypothetical protein; Provisional; Region: PRK11037 1266738003775 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1266738003776 putative inner membrane peptidase; Provisional; Region: PRK11778 1266738003777 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1266738003778 tandem repeat interface [polypeptide binding]; other site 1266738003779 oligomer interface [polypeptide binding]; other site 1266738003780 active site residues [active] 1266738003781 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1266738003782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1266738003783 NAD(P) binding site [chemical binding]; other site 1266738003784 active site 1266738003785 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1266738003786 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 1266738003787 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1266738003788 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1266738003789 RNA binding surface [nucleotide binding]; other site 1266738003790 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1266738003791 probable active site [active] 1266738003792 hypothetical protein; Provisional; Region: PRK11630 1266738003793 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1266738003794 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1266738003795 active site 1266738003796 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1266738003797 anthranilate synthase component I; Provisional; Region: PRK13564 1266738003798 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1266738003799 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1266738003800 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1266738003801 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1266738003802 glutamine binding [chemical binding]; other site 1266738003803 catalytic triad [active] 1266738003804 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1266738003805 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1266738003806 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1266738003807 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1266738003808 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1266738003809 active site 1266738003810 ribulose/triose binding site [chemical binding]; other site 1266738003811 phosphate binding site [ion binding]; other site 1266738003812 substrate (anthranilate) binding pocket [chemical binding]; other site 1266738003813 product (indole) binding pocket [chemical binding]; other site 1266738003814 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1266738003815 active site 1266738003816 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1266738003817 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1266738003818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738003819 catalytic residue [active] 1266738003820 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1266738003821 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1266738003822 substrate binding site [chemical binding]; other site 1266738003823 active site 1266738003824 catalytic residues [active] 1266738003825 heterodimer interface [polypeptide binding]; other site 1266738003826 BON domain; Region: BON; pfam04972 1266738003827 outer membrane protein W; Provisional; Region: PRK10959 1266738003828 Uncharacterized protein family (UPF0259); Region: UPF0259; cl11642 1266738003829 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1266738003830 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1266738003831 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1266738003832 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1266738003833 intracellular septation protein A; Reviewed; Region: PRK00259 1266738003834 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1266738003835 transport protein TonB; Provisional; Region: PRK10819 1266738003836 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1266738003837 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1266738003838 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1266738003839 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1266738003840 putative active site [active] 1266738003841 catalytic site [active] 1266738003842 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1266738003843 putative active site [active] 1266738003844 catalytic site [active] 1266738003845 dsDNA-mimic protein; Reviewed; Region: PRK05094 1266738003846 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1266738003847 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1266738003848 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1266738003849 putative metal binding site [ion binding]; other site 1266738003850 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1266738003851 leucine export protein LeuE; Provisional; Region: PRK10958 1266738003852 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1266738003853 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1266738003854 Ligand Binding Site [chemical binding]; other site 1266738003855 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1266738003856 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1266738003857 Cl binding site [ion binding]; other site 1266738003858 oligomer interface [polypeptide binding]; other site 1266738003859 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1266738003860 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1266738003861 peptide binding site [polypeptide binding]; other site 1266738003862 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1266738003863 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1266738003864 dimer interface [polypeptide binding]; other site 1266738003865 catalytic triad [active] 1266738003866 peroxidatic and resolving cysteines [active] 1266738003867 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 1266738003868 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1266738003869 putative aromatic amino acid binding site; other site 1266738003870 PAS domain; Region: PAS; smart00091 1266738003871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1266738003872 Walker A motif; other site 1266738003873 ATP binding site [chemical binding]; other site 1266738003874 Walker B motif; other site 1266738003875 arginine finger; other site 1266738003876 hypothetical protein; Provisional; Region: PRK05415 1266738003877 Domain of unknown function (DUF697); Region: DUF697; cl12064 1266738003878 Predicted ATPase [General function prediction only]; Region: COG3106 1266738003879 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 1266738003880 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 1266738003881 phage shock protein C; Region: phageshock_pspC; TIGR02978 1266738003882 phage shock protein B; Provisional; Region: pspB; PRK09458 1266738003883 phage shock protein PspA; Provisional; Region: PRK10698 1266738003884 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1266738003885 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1266738003886 Walker A motif; other site 1266738003887 ATP binding site [chemical binding]; other site 1266738003888 Walker B motif; other site 1266738003889 arginine finger; other site 1266738003890 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1266738003891 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1266738003892 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1266738003893 peptide binding site [polypeptide binding]; other site 1266738003894 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 1266738003895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738003896 putative PBP binding loops; other site 1266738003897 ABC-ATPase subunit interface; other site 1266738003898 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1266738003899 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1266738003900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738003901 dimer interface [polypeptide binding]; other site 1266738003902 conserved gate region; other site 1266738003903 putative PBP binding loops; other site 1266738003904 ABC-ATPase subunit interface; other site 1266738003905 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1266738003906 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1266738003907 Walker A/P-loop; other site 1266738003908 ATP binding site [chemical binding]; other site 1266738003909 Q-loop/lid; other site 1266738003910 ABC transporter signature motif; other site 1266738003911 Walker B; other site 1266738003912 D-loop; other site 1266738003913 H-loop/switch region; other site 1266738003914 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1266738003915 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1266738003916 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1266738003917 Walker A/P-loop; other site 1266738003918 ATP binding site [chemical binding]; other site 1266738003919 Q-loop/lid; other site 1266738003920 ABC transporter signature motif; other site 1266738003921 Walker B; other site 1266738003922 D-loop; other site 1266738003923 H-loop/switch region; other site 1266738003924 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1266738003925 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1266738003926 NAD binding site [chemical binding]; other site 1266738003927 homotetramer interface [polypeptide binding]; other site 1266738003928 homodimer interface [polypeptide binding]; other site 1266738003929 substrate binding site [chemical binding]; other site 1266738003930 active site 1266738003931 glutathionine S-transferase; Provisional; Region: PRK10542 1266738003932 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1266738003933 C-terminal domain interface [polypeptide binding]; other site 1266738003934 GSH binding site (G-site) [chemical binding]; other site 1266738003935 dimer interface [polypeptide binding]; other site 1266738003936 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1266738003937 dimer interface [polypeptide binding]; other site 1266738003938 N-terminal domain interface [polypeptide binding]; other site 1266738003939 substrate binding pocket (H-site) [chemical binding]; other site 1266738003940 pyridoxamine kinase; Validated; Region: PRK05756 1266738003941 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1266738003942 dimer interface [polypeptide binding]; other site 1266738003943 pyridoxal binding site [chemical binding]; other site 1266738003944 ATP binding site [chemical binding]; other site 1266738003945 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1266738003946 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1266738003947 active site 1266738003948 HIGH motif; other site 1266738003949 dimer interface [polypeptide binding]; other site 1266738003950 KMSKS motif; other site 1266738003951 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1266738003952 RNA binding surface [nucleotide binding]; other site 1266738003953 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1266738003954 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1266738003955 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1266738003956 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1266738003957 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1266738003958 transcriptional regulator SlyA; Provisional; Region: PRK03573 1266738003959 MarR family; Region: MarR; pfam01047 1266738003960 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 1266738003961 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1266738003962 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1266738003963 dimer interface [polypeptide binding]; other site 1266738003964 active site 1266738003965 metal binding site [ion binding]; metal-binding site 1266738003966 glutathione binding site [chemical binding]; other site 1266738003967 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1266738003968 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1266738003969 dimer interface [polypeptide binding]; other site 1266738003970 catalytic site [active] 1266738003971 putative active site [active] 1266738003972 putative substrate binding site [chemical binding]; other site 1266738003973 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1266738003974 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1266738003975 Probable transposase; Region: OrfB_IS605; pfam01385 1266738003976 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1266738003977 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1266738003978 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1266738003979 putative GSH binding site [chemical binding]; other site 1266738003980 catalytic residues [active] 1266738003981 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1266738003982 Predicted permeases [General function prediction only]; Region: COG0730 1266738003983 superoxide dismutase; Provisional; Region: PRK10543 1266738003984 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1266738003985 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1266738003986 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1266738003987 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1266738003988 DNA binding site [nucleotide binding] 1266738003989 domain linker motif; other site 1266738003990 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1266738003991 dimerization interface [polypeptide binding]; other site 1266738003992 ligand binding site [chemical binding]; other site 1266738003993 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1266738003994 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738003995 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1266738003996 dimerization interface [polypeptide binding]; other site 1266738003997 putative transporter; Provisional; Region: PRK11043 1266738003998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738003999 putative substrate translocation pore; other site 1266738004000 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1266738004001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1266738004002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738004003 S-adenosylmethionine binding site [chemical binding]; other site 1266738004004 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1266738004005 Lumazine binding domain; Region: Lum_binding; pfam00677 1266738004006 Lumazine binding domain; Region: Lum_binding; pfam00677 1266738004007 multidrug efflux protein; Reviewed; Region: PRK01766 1266738004008 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1266738004009 cation binding site [ion binding]; other site 1266738004010 pyruvate kinase; Provisional; Region: PRK09206 1266738004011 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1266738004012 domain interfaces; other site 1266738004013 active site 1266738004014 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 1266738004015 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1266738004016 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738004017 catalytic residue [active] 1266738004018 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1266738004019 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1266738004020 active site 1266738004021 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539 1266738004022 L,D-transpeptidase; Provisional; Region: PRK10190 1266738004023 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1266738004024 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1266738004025 Fe-S metabolism associated domain; Region: SufE; cl00951 1266738004026 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1266738004027 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1266738004028 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1266738004029 catalytic residue [active] 1266738004030 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1266738004031 FeS assembly protein SufD; Region: sufD; TIGR01981 1266738004032 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1266738004033 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1266738004034 Walker A/P-loop; other site 1266738004035 ATP binding site [chemical binding]; other site 1266738004036 Q-loop/lid; other site 1266738004037 ABC transporter signature motif; other site 1266738004038 Walker B; other site 1266738004039 D-loop; other site 1266738004040 H-loop/switch region; other site 1266738004041 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1266738004042 putative ABC transporter; Region: ycf24; CHL00085 1266738004043 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1266738004044 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1266738004045 CoenzymeA binding site [chemical binding]; other site 1266738004046 subunit interaction site [polypeptide binding]; other site 1266738004047 PHB binding site; other site 1266738004048 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1266738004049 FAD binding domain; Region: FAD_binding_4; pfam01565 1266738004050 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1266738004051 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1266738004052 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1266738004053 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1266738004054 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1266738004055 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1266738004056 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1266738004057 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1266738004058 N-terminal plug; other site 1266738004059 ligand-binding site [chemical binding]; other site 1266738004060 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1266738004061 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1266738004062 N-terminal plug; other site 1266738004063 ligand-binding site [chemical binding]; other site 1266738004064 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 1266738004065 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1266738004066 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1266738004067 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 1266738004068 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1266738004069 putative hemin binding site; other site 1266738004070 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1266738004071 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1266738004072 ABC-ATPase subunit interface; other site 1266738004073 dimer interface [polypeptide binding]; other site 1266738004074 putative PBP binding regions; other site 1266738004075 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1266738004076 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1266738004077 Walker A/P-loop; other site 1266738004078 ATP binding site [chemical binding]; other site 1266738004079 Q-loop/lid; other site 1266738004080 ABC transporter signature motif; other site 1266738004081 Walker B; other site 1266738004082 D-loop; other site 1266738004083 H-loop/switch region; other site 1266738004084 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1266738004085 putative Zn2+ binding site [ion binding]; other site 1266738004086 putative DNA binding site [nucleotide binding]; other site 1266738004087 AsnC family; Region: AsnC_trans_reg; pfam01037 1266738004088 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1266738004089 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1266738004090 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1266738004091 DNA-binding site [nucleotide binding]; DNA binding site 1266738004092 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1266738004093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738004094 homodimer interface [polypeptide binding]; other site 1266738004095 catalytic residue [active] 1266738004096 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1266738004097 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1266738004098 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1266738004099 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1266738004100 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1266738004101 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1266738004102 FAD binding pocket [chemical binding]; other site 1266738004103 FAD binding motif [chemical binding]; other site 1266738004104 phosphate binding motif [ion binding]; other site 1266738004105 NAD binding pocket [chemical binding]; other site 1266738004106 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1266738004107 hypothetical protein; Provisional; Region: PRK10536 1266738004108 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1266738004109 DNA-specific endonuclease I; Provisional; Region: PRK15137 1266738004110 Endonuclease I; Region: Endonuclease_1; pfam04231 1266738004111 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1266738004112 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1266738004113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738004114 AAA domain; Region: AAA_21; pfam13304 1266738004115 Walker A/P-loop; other site 1266738004116 ATP binding site [chemical binding]; other site 1266738004117 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738004118 Q-loop/lid; other site 1266738004119 ABC transporter signature motif; other site 1266738004120 Walker B; other site 1266738004121 D-loop; other site 1266738004122 H-loop/switch region; other site 1266738004123 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1266738004124 Ligand Binding Site [chemical binding]; other site 1266738004125 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1266738004126 Ligand Binding Site [chemical binding]; other site 1266738004127 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1266738004128 putative substrate binding site [chemical binding]; other site 1266738004129 putative ATP binding site [chemical binding]; other site 1266738004130 hypothetical protein; Provisional; Region: PRK10613 1266738004131 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1266738004132 dimer interface [polypeptide binding]; other site 1266738004133 active site 1266738004134 Schiff base residues; other site 1266738004135 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1266738004136 nucleotide binding site/active site [active] 1266738004137 cytosine deaminase; Provisional; Region: PRK09230 1266738004138 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1266738004139 active site 1266738004140 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 1266738004141 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1266738004142 Na binding site [ion binding]; other site 1266738004143 putative substrate binding site [chemical binding]; other site 1266738004144 choline dehydrogenase; Validated; Region: PRK02106 1266738004145 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1266738004146 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1266738004147 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1266738004148 tetrameric interface [polypeptide binding]; other site 1266738004149 NAD binding site [chemical binding]; other site 1266738004150 catalytic residues [active] 1266738004151 transcriptional regulator BetI; Validated; Region: PRK00767 1266738004152 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1266738004153 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1266738004154 choline transport protein BetT; Provisional; Region: PRK09928 1266738004155 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 1266738004156 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1266738004157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738004158 homodimer interface [polypeptide binding]; other site 1266738004159 catalytic residue [active] 1266738004160 Fimbrial protein; Region: Fimbrial; cl01416 1266738004161 Fimbrial protein; Region: Fimbrial; cl01416 1266738004162 Fimbrial protein; Region: Fimbrial; cl01416 1266738004163 outer membrane usher protein; Provisional; Region: PRK15193 1266738004164 PapC N-terminal domain; Region: PapC_N; pfam13954 1266738004165 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1266738004166 PapC C-terminal domain; Region: PapC_C; pfam13953 1266738004167 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 1266738004168 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1266738004169 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1266738004170 Fimbrial protein; Region: Fimbrial; cl01416 1266738004171 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1266738004172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738004173 sequence-specific DNA binding site [nucleotide binding]; other site 1266738004174 salt bridge; other site 1266738004175 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1266738004176 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1266738004177 Walker A/P-loop; other site 1266738004178 ATP binding site [chemical binding]; other site 1266738004179 Q-loop/lid; other site 1266738004180 ABC transporter signature motif; other site 1266738004181 Walker B; other site 1266738004182 D-loop; other site 1266738004183 H-loop/switch region; other site 1266738004184 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1266738004185 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1266738004186 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1266738004187 Walker A/P-loop; other site 1266738004188 ATP binding site [chemical binding]; other site 1266738004189 Q-loop/lid; other site 1266738004190 ABC transporter signature motif; other site 1266738004191 Walker B; other site 1266738004192 D-loop; other site 1266738004193 H-loop/switch region; other site 1266738004194 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1266738004195 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1266738004196 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1266738004197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738004198 dimer interface [polypeptide binding]; other site 1266738004199 conserved gate region; other site 1266738004200 ABC-ATPase subunit interface; other site 1266738004201 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1266738004202 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1266738004203 peptide binding site [polypeptide binding]; other site 1266738004204 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1266738004205 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1266738004206 peptide binding site [polypeptide binding]; other site 1266738004207 siroheme synthase; Provisional; Region: cysG; PRK10637 1266738004208 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1266738004209 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1266738004210 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1266738004211 active site 1266738004212 SAM binding site [chemical binding]; other site 1266738004213 homodimer interface [polypeptide binding]; other site 1266738004214 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1266738004215 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1266738004216 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1266738004217 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1266738004218 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1266738004219 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1266738004220 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1266738004221 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1266738004222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738004223 dimer interface [polypeptide binding]; other site 1266738004224 conserved gate region; other site 1266738004225 putative PBP binding loops; other site 1266738004226 ABC-ATPase subunit interface; other site 1266738004227 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1266738004228 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1266738004229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738004230 dimer interface [polypeptide binding]; other site 1266738004231 conserved gate region; other site 1266738004232 ABC-ATPase subunit interface; other site 1266738004233 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1266738004234 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1266738004235 Walker A/P-loop; other site 1266738004236 ATP binding site [chemical binding]; other site 1266738004237 Q-loop/lid; other site 1266738004238 ABC transporter signature motif; other site 1266738004239 Walker B; other site 1266738004240 D-loop; other site 1266738004241 H-loop/switch region; other site 1266738004242 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1266738004243 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1266738004244 Walker A/P-loop; other site 1266738004245 ATP binding site [chemical binding]; other site 1266738004246 Q-loop/lid; other site 1266738004247 ABC transporter signature motif; other site 1266738004248 Walker B; other site 1266738004249 D-loop; other site 1266738004250 H-loop/switch region; other site 1266738004251 hypothetical protein; Provisional; Region: PRK11111 1266738004252 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1266738004253 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1266738004254 putative catalytic cysteine [active] 1266738004255 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1266738004256 putative active site [active] 1266738004257 metal binding site [ion binding]; metal-binding site 1266738004258 thymidine kinase; Provisional; Region: PRK04296 1266738004259 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1266738004260 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1266738004261 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1266738004262 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1266738004263 putative NAD(P) binding site [chemical binding]; other site 1266738004264 active site 1266738004265 putative substrate binding site [chemical binding]; other site 1266738004266 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1266738004267 active site 1266738004268 tetramer interface; other site 1266738004269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738004270 active site 1266738004271 response regulator of RpoS; Provisional; Region: PRK10693 1266738004272 phosphorylation site [posttranslational modification] 1266738004273 intermolecular recognition site; other site 1266738004274 dimerization interface [polypeptide binding]; other site 1266738004275 hypothetical protein; Provisional; Region: PRK01617 1266738004276 SEC-C motif; Region: SEC-C; pfam02810 1266738004277 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1266738004278 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1266738004279 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1266738004280 putative active site [active] 1266738004281 putative substrate binding site [chemical binding]; other site 1266738004282 putative cosubstrate binding site; other site 1266738004283 catalytic site [active] 1266738004284 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1266738004285 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738004286 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1266738004287 putative catalytic site [active] 1266738004288 putative phosphate binding site [ion binding]; other site 1266738004289 active site 1266738004290 metal binding site A [ion binding]; metal-binding site 1266738004291 DNA binding site [nucleotide binding] 1266738004292 putative AP binding site [nucleotide binding]; other site 1266738004293 putative metal binding site B [ion binding]; other site 1266738004294 DNA topoisomerase III; Provisional; Region: PRK07726 1266738004295 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1266738004296 active site 1266738004297 putative interdomain interaction site [polypeptide binding]; other site 1266738004298 putative metal-binding site [ion binding]; other site 1266738004299 putative nucleotide binding site [chemical binding]; other site 1266738004300 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1266738004301 domain I; other site 1266738004302 DNA binding groove [nucleotide binding] 1266738004303 phosphate binding site [ion binding]; other site 1266738004304 domain II; other site 1266738004305 domain III; other site 1266738004306 nucleotide binding site [chemical binding]; other site 1266738004307 catalytic site [active] 1266738004308 domain IV; other site 1266738004309 selenophosphate synthetase; Provisional; Region: PRK00943 1266738004310 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1266738004311 dimerization interface [polypeptide binding]; other site 1266738004312 putative ATP binding site [chemical binding]; other site 1266738004313 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1266738004314 putative FMN binding site [chemical binding]; other site 1266738004315 protease 4; Provisional; Region: PRK10949 1266738004316 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1266738004317 tandem repeat interface [polypeptide binding]; other site 1266738004318 oligomer interface [polypeptide binding]; other site 1266738004319 active site residues [active] 1266738004320 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1266738004321 tandem repeat interface [polypeptide binding]; other site 1266738004322 oligomer interface [polypeptide binding]; other site 1266738004323 active site residues [active] 1266738004324 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1266738004325 active site 1266738004326 homodimer interface [polypeptide binding]; other site 1266738004327 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1266738004328 Isochorismatase family; Region: Isochorismatase; pfam00857 1266738004329 catalytic triad [active] 1266738004330 metal binding site [ion binding]; metal-binding site 1266738004331 conserved cis-peptide bond; other site 1266738004332 TIGR02646 family protein; Region: TIGR02646 1266738004333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738004334 AAA domain; Region: AAA_23; pfam13476 1266738004335 Walker A/P-loop; other site 1266738004336 ATP binding site [chemical binding]; other site 1266738004337 AAA domain; Region: AAA_21; pfam13304 1266738004338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738004339 ABC transporter signature motif; other site 1266738004340 Walker B; other site 1266738004341 D-loop; other site 1266738004342 H-loop/switch region; other site 1266738004343 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 1266738004344 SelR domain; Region: SelR; pfam01641 1266738004345 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1266738004346 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1266738004347 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1266738004348 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1266738004349 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1266738004350 active site 1266738004351 phosphate binding residues; other site 1266738004352 catalytic residues [active] 1266738004353 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1266738004354 Acylphosphatase; Region: Acylphosphatase; pfam00708 1266738004355 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1266738004356 HypF finger; Region: zf-HYPF; pfam07503 1266738004357 HypF finger; Region: zf-HYPF; pfam07503 1266738004358 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1266738004359 Fumble; Region: Fumble; cl17357 1266738004360 alanine racemase; Reviewed; Region: dadX; PRK03646 1266738004361 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1266738004362 active site 1266738004363 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1266738004364 substrate binding site [chemical binding]; other site 1266738004365 catalytic residues [active] 1266738004366 dimer interface [polypeptide binding]; other site 1266738004367 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1266738004368 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1266738004369 fatty acid metabolism regulator; Provisional; Region: PRK04984 1266738004370 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1266738004371 DNA-binding site [nucleotide binding]; DNA binding site 1266738004372 FadR C-terminal domain; Region: FadR_C; pfam07840 1266738004373 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 1266738004374 disulfide bond formation protein B; Provisional; Region: PRK01749 1266738004375 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1266738004376 putative arabinose transporter; Provisional; Region: PRK03545 1266738004377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738004378 putative substrate translocation pore; other site 1266738004379 Domain of unknown function (DUF305); Region: DUF305; cl17794 1266738004380 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1266738004381 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 1266738004382 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 1266738004383 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1266738004384 DNA binding residues [nucleotide binding] 1266738004385 dimerization interface [polypeptide binding]; other site 1266738004386 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1266738004387 dimer interface [polypeptide binding]; other site 1266738004388 FMN binding site [chemical binding]; other site 1266738004389 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1266738004390 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1266738004391 putative active site [active] 1266738004392 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1266738004393 active site 1266738004394 substrate binding pocket [chemical binding]; other site 1266738004395 homodimer interaction site [polypeptide binding]; other site 1266738004396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1266738004397 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1266738004398 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1266738004399 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1266738004400 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1266738004401 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1266738004402 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1266738004403 substrate binding site [chemical binding]; other site 1266738004404 dimer interface [polypeptide binding]; other site 1266738004405 ATP binding site [chemical binding]; other site 1266738004406 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1266738004407 Zn2+ binding site [ion binding]; other site 1266738004408 Mg2+ binding site [ion binding]; other site 1266738004409 AAA domain; Region: AAA_33; pfam13671 1266738004410 RNA ligase; Region: RNA_ligase; pfam09414 1266738004411 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1266738004412 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1266738004413 NAD binding site [chemical binding]; other site 1266738004414 homodimer interface [polypeptide binding]; other site 1266738004415 active site 1266738004416 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1266738004417 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 1266738004418 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738004419 non-specific DNA binding site [nucleotide binding]; other site 1266738004420 salt bridge; other site 1266738004421 Predicted transcriptional regulator [Transcription]; Region: COG2932 1266738004422 sequence-specific DNA binding site [nucleotide binding]; other site 1266738004423 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1266738004424 Catalytic site [active] 1266738004425 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738004426 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1266738004427 Walker A/P-loop; other site 1266738004428 ATP binding site [chemical binding]; other site 1266738004429 Q-loop/lid; other site 1266738004430 ABC transporter signature motif; other site 1266738004431 Walker B; other site 1266738004432 D-loop; other site 1266738004433 H-loop/switch region; other site 1266738004434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738004435 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1266738004436 putative PBP binding loops; other site 1266738004437 ABC-ATPase subunit interface; other site 1266738004438 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1266738004439 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1266738004440 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1266738004441 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1266738004442 DNA binding residues [nucleotide binding] 1266738004443 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1266738004444 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091 1266738004445 30S ribosomal protein subunit S22 family; Region: Ribosomal_S22; cl11579 1266738004446 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 1266738004447 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1266738004448 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1266738004449 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1266738004450 hypothetical protein; Provisional; Region: PHA02515 1266738004451 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1266738004452 structural protein; Region: PHA01972 1266738004453 virion protein; Provisional; Region: V; PHA02564 1266738004454 hypothetical protein; Region: PHA00660 1266738004455 hypothetical protein; Region: PHA01733 1266738004456 hypothetical protein; Region: PHA00661 1266738004457 hypothetical protein; Region: PHA00662 1266738004458 hypothetical protein; Region: PHA00669 1266738004459 hypothetical protein; Region: PHA00664 1266738004460 major capsid protein; Region: PHA00665 1266738004461 putative protease; Region: PHA00666 1266738004462 hypothetical protein; Region: PHA00670 1266738004463 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 1266738004464 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1266738004465 Replication protein P; Region: Phage_lambda_P; pfam06992 1266738004466 primosomal protein DnaI; Provisional; Region: PRK02854 1266738004467 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1266738004468 exonuclease VIII; Reviewed; Region: PRK09709 1266738004469 exonuclease VIII; Reviewed; Region: PRK09709 1266738004470 RecT family; Region: RecT; pfam03837 1266738004471 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 1266738004472 YfbU domain; Region: YfbU; cl01137 1266738004473 MT-A70; Region: MT-A70; cl01947 1266738004474 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1266738004475 active site 1266738004476 Int/Topo IB signature motif; other site 1266738004477 GMP synthase; Reviewed; Region: guaA; PRK00074 1266738004478 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1266738004479 AMP/PPi binding site [chemical binding]; other site 1266738004480 candidate oxyanion hole; other site 1266738004481 catalytic triad [active] 1266738004482 potential glutamine specificity residues [chemical binding]; other site 1266738004483 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1266738004484 ATP Binding subdomain [chemical binding]; other site 1266738004485 Ligand Binding sites [chemical binding]; other site 1266738004486 Dimerization subdomain; other site 1266738004487 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1266738004488 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1266738004489 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1266738004490 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1266738004491 active site 1266738004492 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1266738004493 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1266738004494 generic binding surface II; other site 1266738004495 generic binding surface I; other site 1266738004496 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1266738004497 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1266738004498 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1266738004499 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1266738004500 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1266738004501 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1266738004502 Protein of unknown function, DUF399; Region: DUF399; pfam04187 1266738004503 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1266738004504 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1266738004505 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1266738004506 putative NAD(P) binding site [chemical binding]; other site 1266738004507 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1266738004508 transcriptional regulator NarP; Provisional; Region: PRK10403 1266738004509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738004510 active site 1266738004511 phosphorylation site [posttranslational modification] 1266738004512 intermolecular recognition site; other site 1266738004513 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1266738004514 DNA binding residues [nucleotide binding] 1266738004515 dimerization interface [polypeptide binding]; other site 1266738004516 ArsC family; Region: ArsC; pfam03960 1266738004517 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1266738004518 putative catalytic residues [active] 1266738004519 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1266738004520 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1266738004521 metal binding site [ion binding]; metal-binding site 1266738004522 dimer interface [polypeptide binding]; other site 1266738004523 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1266738004524 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1266738004525 hypothetical protein; Provisional; Region: PRK10527 1266738004526 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1266738004527 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 1266738004528 Helicase; Region: Helicase_RecD; pfam05127 1266738004529 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1266738004530 Coenzyme A binding pocket [chemical binding]; other site 1266738004531 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 1266738004532 Predicted membrane protein [Function unknown]; Region: COG2707 1266738004533 Predicted metalloprotease [General function prediction only]; Region: COG2321 1266738004534 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1266738004535 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1266738004536 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1266738004537 ATP binding site [chemical binding]; other site 1266738004538 active site 1266738004539 substrate binding site [chemical binding]; other site 1266738004540 lipoprotein; Provisional; Region: PRK11679 1266738004541 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1266738004542 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1266738004543 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1266738004544 dimer interface [polypeptide binding]; other site 1266738004545 active site 1266738004546 catalytic residue [active] 1266738004547 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1266738004548 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1266738004549 ACT domain; Region: ACT_5; pfam13710 1266738004550 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1266738004551 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1266738004552 catalytic triad [active] 1266738004553 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1266738004554 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1266738004555 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1266738004556 Peptidase family M48; Region: Peptidase_M48; pfam01435 1266738004557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1266738004558 TPR motif; other site 1266738004559 binding surface 1266738004560 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1266738004561 ArsC family; Region: ArsC; pfam03960 1266738004562 catalytic residues [active] 1266738004563 nucleoside transporter; Region: 2A0110; TIGR00889 1266738004564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738004565 putative substrate translocation pore; other site 1266738004566 DNA replication initiation factor; Provisional; Region: PRK08084 1266738004567 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1266738004568 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1266738004569 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1266738004570 uracil transporter; Provisional; Region: PRK10720 1266738004571 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1266738004572 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1266738004573 dimerization interface [polypeptide binding]; other site 1266738004574 putative ATP binding site [chemical binding]; other site 1266738004575 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1266738004576 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1266738004577 active site 1266738004578 substrate binding site [chemical binding]; other site 1266738004579 cosubstrate binding site; other site 1266738004580 catalytic site [active] 1266738004581 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1266738004582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1266738004583 Coenzyme A binding pocket [chemical binding]; other site 1266738004584 polyphosphate kinase; Provisional; Region: PRK05443 1266738004585 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1266738004586 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1266738004587 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 1266738004588 domain interface [polypeptide binding]; other site 1266738004589 active site 1266738004590 catalytic site [active] 1266738004591 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 1266738004592 domain interface [polypeptide binding]; other site 1266738004593 active site 1266738004594 catalytic site [active] 1266738004595 exopolyphosphatase; Provisional; Region: PRK10854 1266738004596 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1266738004597 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1266738004598 MgtE intracellular N domain; Region: MgtE_N; smart00924 1266738004599 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1266738004600 Divalent cation transporter; Region: MgtE; cl00786 1266738004601 metabolite-proton symporter; Region: 2A0106; TIGR00883 1266738004602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738004603 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1266738004604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738004605 putative substrate translocation pore; other site 1266738004606 POT family; Region: PTR2; pfam00854 1266738004607 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1266738004608 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1266738004609 HlyD family secretion protein; Region: HlyD_3; pfam13437 1266738004610 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1266738004611 Protein export membrane protein; Region: SecD_SecF; cl14618 1266738004612 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1266738004613 Protein export membrane protein; Region: SecD_SecF; cl14618 1266738004614 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1266738004615 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1266738004616 dimerization interface [polypeptide binding]; other site 1266738004617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1266738004618 dimer interface [polypeptide binding]; other site 1266738004619 phosphorylation site [posttranslational modification] 1266738004620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1266738004621 ATP binding site [chemical binding]; other site 1266738004622 Mg2+ binding site [ion binding]; other site 1266738004623 G-X-G motif; other site 1266738004624 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1266738004625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738004626 active site 1266738004627 phosphorylation site [posttranslational modification] 1266738004628 intermolecular recognition site; other site 1266738004629 dimerization interface [polypeptide binding]; other site 1266738004630 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1266738004631 DNA binding site [nucleotide binding] 1266738004632 putative protease; Provisional; Region: PRK15452 1266738004633 Peptidase family U32; Region: Peptidase_U32; pfam01136 1266738004634 lipid kinase; Reviewed; Region: PRK13054 1266738004635 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1266738004636 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1266738004637 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1266738004638 putative active site; other site 1266738004639 catalytic residue [active] 1266738004640 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1266738004641 substrate binding site [chemical binding]; other site 1266738004642 dimer interface [polypeptide binding]; other site 1266738004643 ATP binding site [chemical binding]; other site 1266738004644 Antimicrobial peptide resistance and lipid A acylation protein PagP; Region: PagP; cl06181 1266738004645 aromatic amino acid transporter; Provisional; Region: PRK10238 1266738004646 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1266738004647 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1266738004648 sugar phosphate phosphatase; Provisional; Region: PRK10513 1266738004649 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1266738004650 active site 1266738004651 motif I; other site 1266738004652 motif II; other site 1266738004653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1266738004654 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1266738004655 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1266738004656 amidase catalytic site [active] 1266738004657 Zn binding residues [ion binding]; other site 1266738004658 substrate binding site [chemical binding]; other site 1266738004659 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1266738004660 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1266738004661 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1266738004662 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 1266738004663 YebF-like protein; Region: YebF; pfam13995 1266738004664 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1266738004665 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1266738004666 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1266738004667 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1266738004668 putative active site [active] 1266738004669 putative CoA binding site [chemical binding]; other site 1266738004670 nudix motif; other site 1266738004671 metal binding site [ion binding]; metal-binding site 1266738004672 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1266738004673 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1266738004674 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1266738004675 hypothetical protein; Provisional; Region: PRK11469 1266738004676 Domain of unknown function DUF; Region: DUF204; pfam02659 1266738004677 Domain of unknown function DUF; Region: DUF204; pfam02659 1266738004678 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1266738004679 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738004680 S-adenosylmethionine binding site [chemical binding]; other site 1266738004681 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1266738004682 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1266738004683 Ligand Binding Site [chemical binding]; other site 1266738004684 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 1266738004685 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1266738004686 Ligand Binding Site [chemical binding]; other site 1266738004687 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1266738004688 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1266738004689 Predicted transcriptional regulator [Transcription]; Region: COG3905 1266738004690 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1266738004691 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1266738004692 Glutamate binding site [chemical binding]; other site 1266738004693 NAD binding site [chemical binding]; other site 1266738004694 catalytic residues [active] 1266738004695 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 1266738004696 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1266738004697 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1266738004698 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1266738004699 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1266738004700 DNA binding residues [nucleotide binding] 1266738004701 flagellin; Validated; Region: PRK06819 1266738004702 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1266738004703 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1266738004704 flagellin; Validated; Region: PRK06819 1266738004705 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1266738004706 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1266738004707 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1266738004708 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1266738004709 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1266738004710 flagellar protein FliS; Validated; Region: fliS; PRK05685 1266738004711 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1266738004712 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1266738004713 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1266738004714 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1266738004715 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1266738004716 FliG C-terminal domain; Region: FliG_C; pfam01706 1266738004717 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1266738004718 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 1266738004719 Flagellar assembly protein FliH; Region: FliH; pfam02108 1266738004720 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 1266738004721 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1266738004722 Walker A motif/ATP binding site; other site 1266738004723 Walker B motif; other site 1266738004724 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1266738004725 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1266738004726 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 1266738004727 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1266738004728 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 1266738004729 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1266738004730 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1266738004731 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 1266738004732 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1266738004733 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1266738004734 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1266738004735 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1266738004736 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1266738004737 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1266738004738 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1266738004739 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1266738004740 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1266738004741 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1266738004742 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1266738004743 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1266738004744 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1266738004745 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1266738004746 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1266738004747 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1266738004748 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1266738004749 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1266738004750 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1266738004751 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1266738004752 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1266738004753 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1266738004754 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1266738004755 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1266738004756 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1266738004757 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1266738004758 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1266738004759 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1266738004760 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1266738004761 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1266738004762 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1266738004763 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1266738004764 SAF-like; Region: SAF_2; pfam13144 1266738004765 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1266738004766 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1266738004767 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 1266738004768 FlgN protein; Region: FlgN; cl09176 1266738004769 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1266738004770 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1266738004771 FHIPEP family; Region: FHIPEP; pfam00771 1266738004772 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 1266738004773 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1266738004774 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1266738004775 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 1266738004776 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1266738004777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738004778 active site 1266738004779 phosphorylation site [posttranslational modification] 1266738004780 intermolecular recognition site; other site 1266738004781 dimerization interface [polypeptide binding]; other site 1266738004782 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1266738004783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738004784 active site 1266738004785 phosphorylation site [posttranslational modification] 1266738004786 intermolecular recognition site; other site 1266738004787 dimerization interface [polypeptide binding]; other site 1266738004788 CheB methylesterase; Region: CheB_methylest; pfam01339 1266738004789 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 1266738004790 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1266738004791 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1266738004792 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1266738004793 dimer interface [polypeptide binding]; other site 1266738004794 ligand binding site [chemical binding]; other site 1266738004795 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1266738004796 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1266738004797 dimerization interface [polypeptide binding]; other site 1266738004798 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1266738004799 dimer interface [polypeptide binding]; other site 1266738004800 putative CheW interface [polypeptide binding]; other site 1266738004801 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1266738004802 putative CheA interaction surface; other site 1266738004803 chemotaxis protein CheA; Provisional; Region: PRK10547 1266738004804 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1266738004805 putative binding surface; other site 1266738004806 active site 1266738004807 CheY binding; Region: CheY-binding; pfam09078 1266738004808 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1266738004809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1266738004810 ATP binding site [chemical binding]; other site 1266738004811 Mg2+ binding site [ion binding]; other site 1266738004812 G-X-G motif; other site 1266738004813 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1266738004814 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1266738004815 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1266738004816 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1266738004817 ligand binding site [chemical binding]; other site 1266738004818 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1266738004819 flagellar motor protein MotA; Validated; Region: PRK09110 1266738004820 transcriptional activator FlhC; Provisional; Region: PRK12722 1266738004821 magnesium transport protein MgtC; Provisional; Region: PRK15385 1266738004822 MgtC family; Region: MgtC; pfam02308 1266738004823 hypothetical protein; Provisional; Region: PRK10708 1266738004824 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1266738004825 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1266738004826 active site 1266738004827 substrate binding pocket [chemical binding]; other site 1266738004828 dimer interface [polypeptide binding]; other site 1266738004829 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1266738004830 cheY-homologous receiver domain; Region: REC; smart00448 1266738004831 tetrathionate reductase subunit A; Provisional; Region: PRK14991 1266738004832 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 1266738004833 putative [Fe4-S4] binding site [ion binding]; other site 1266738004834 putative molybdopterin cofactor binding site [chemical binding]; other site 1266738004835 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 1266738004836 putative molybdopterin cofactor binding site; other site 1266738004837 tetrathionate reductase subunit C; Provisional; Region: PRK14992 1266738004838 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1266738004839 tetrathionate reductase subunit B; Provisional; Region: PRK14993 1266738004840 4Fe-4S binding domain; Region: Fer4; pfam00037 1266738004841 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1266738004842 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1266738004843 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1266738004844 dimer interface [polypeptide binding]; other site 1266738004845 phosphorylation site [posttranslational modification] 1266738004846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1266738004847 ATP binding site [chemical binding]; other site 1266738004848 Mg2+ binding site [ion binding]; other site 1266738004849 G-X-G motif; other site 1266738004850 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1266738004851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738004852 active site 1266738004853 phosphorylation site [posttranslational modification] 1266738004854 intermolecular recognition site; other site 1266738004855 dimerization interface [polypeptide binding]; other site 1266738004856 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1266738004857 DNA binding residues [nucleotide binding] 1266738004858 dimerization interface [polypeptide binding]; other site 1266738004859 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1266738004860 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1266738004861 putative acyl-acceptor binding pocket; other site 1266738004862 POT family; Region: PTR2; cl17359 1266738004863 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 1266738004864 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1266738004865 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1266738004866 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1266738004867 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1266738004868 trimer interface [polypeptide binding]; other site 1266738004869 active site 1266738004870 substrate binding site [chemical binding]; other site 1266738004871 CoA binding site [chemical binding]; other site 1266738004872 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1266738004873 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1266738004874 active site 1266738004875 FMN binding site [chemical binding]; other site 1266738004876 substrate binding site [chemical binding]; other site 1266738004877 homotetramer interface [polypeptide binding]; other site 1266738004878 catalytic residue [active] 1266738004879 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 1266738004880 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1266738004881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738004882 active site 1266738004883 phosphorylation site [posttranslational modification] 1266738004884 intermolecular recognition site; other site 1266738004885 dimerization interface [polypeptide binding]; other site 1266738004886 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1266738004887 DNA binding site [nucleotide binding] 1266738004888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1266738004889 dimer interface [polypeptide binding]; other site 1266738004890 phosphorylation site [posttranslational modification] 1266738004891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1266738004892 ATP binding site [chemical binding]; other site 1266738004893 Mg2+ binding site [ion binding]; other site 1266738004894 G-X-G motif; other site 1266738004895 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1266738004896 AzlC protein; Region: AzlC; cl00570 1266738004897 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1266738004898 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738004899 non-specific DNA binding site [nucleotide binding]; other site 1266738004900 salt bridge; other site 1266738004901 sequence-specific DNA binding site [nucleotide binding]; other site 1266738004902 Cupin domain; Region: Cupin_2; cl17218 1266738004903 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1266738004904 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1266738004905 homodimer interface [polypeptide binding]; other site 1266738004906 substrate-cofactor binding pocket; other site 1266738004907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738004908 catalytic residue [active] 1266738004909 acid-resistance membrane protein; Provisional; Region: PRK10209 1266738004910 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1266738004911 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1266738004912 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1266738004913 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1266738004914 molybdopterin cofactor binding site; other site 1266738004915 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1266738004916 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1266738004917 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 1266738004918 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1266738004919 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1266738004920 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1266738004921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1266738004922 Coenzyme A binding pocket [chemical binding]; other site 1266738004923 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1266738004924 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 1266738004925 Baseplate J-like protein; Region: Baseplate_J; cl01294 1266738004926 Phage Connector (GP10); Region: Phage_connector; cl11526 1266738004927 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 1266738004928 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 1266738004929 virion protein; Provisional; Region: V; PHA02564 1266738004930 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 1266738004931 Antitermination protein; Region: Antiterm; pfam03589 1266738004932 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1266738004933 Predicted transcriptional regulator [Transcription]; Region: COG2932 1266738004934 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738004935 non-specific DNA binding site [nucleotide binding]; other site 1266738004936 salt bridge; other site 1266738004937 sequence-specific DNA binding site [nucleotide binding]; other site 1266738004938 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1266738004939 Catalytic site [active] 1266738004940 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1266738004941 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1266738004942 active site 1266738004943 HIGH motif; other site 1266738004944 dimer interface [polypeptide binding]; other site 1266738004945 KMSKS motif; other site 1266738004946 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 1266738004947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1266738004948 ATP binding site [chemical binding]; other site 1266738004949 Mg2+ binding site [ion binding]; other site 1266738004950 G-X-G motif; other site 1266738004951 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1266738004952 putative binding surface; other site 1266738004953 active site 1266738004954 transcriptional regulator RcsB; Provisional; Region: PRK10840 1266738004955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738004956 active site 1266738004957 phosphorylation site [posttranslational modification] 1266738004958 intermolecular recognition site; other site 1266738004959 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1266738004960 DNA binding residues [nucleotide binding] 1266738004961 dimerization interface [polypeptide binding]; other site 1266738004962 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 1266738004963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1266738004964 dimer interface [polypeptide binding]; other site 1266738004965 phosphorylation site [posttranslational modification] 1266738004966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1266738004967 ATP binding site [chemical binding]; other site 1266738004968 Mg2+ binding site [ion binding]; other site 1266738004969 G-X-G motif; other site 1266738004970 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 1266738004971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738004972 active site 1266738004973 phosphorylation site [posttranslational modification] 1266738004974 intermolecular recognition site; other site 1266738004975 dimerization interface [polypeptide binding]; other site 1266738004976 DNA gyrase subunit A; Validated; Region: PRK05560 1266738004977 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1266738004978 CAP-like domain; other site 1266738004979 active site 1266738004980 primary dimer interface [polypeptide binding]; other site 1266738004981 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1266738004982 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1266738004983 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1266738004984 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1266738004985 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1266738004986 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1266738004987 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1266738004988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738004989 S-adenosylmethionine binding site [chemical binding]; other site 1266738004990 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1266738004991 ATP cone domain; Region: ATP-cone; pfam03477 1266738004992 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1266738004993 active site 1266738004994 dimer interface [polypeptide binding]; other site 1266738004995 catalytic residues [active] 1266738004996 effector binding site; other site 1266738004997 R2 peptide binding site; other site 1266738004998 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1266738004999 dimer interface [polypeptide binding]; other site 1266738005000 putative radical transfer pathway; other site 1266738005001 diiron center [ion binding]; other site 1266738005002 tyrosyl radical; other site 1266738005003 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1266738005004 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1266738005005 catalytic loop [active] 1266738005006 iron binding site [ion binding]; other site 1266738005007 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1266738005008 tyrosine transporter TyrP; Provisional; Region: PRK15132 1266738005009 aromatic amino acid transport protein; Region: araaP; TIGR00837 1266738005010 YfaZ precursor; Region: YfaZ; pfam07437 1266738005011 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 1266738005012 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1266738005013 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1266738005014 tetramer interface [polypeptide binding]; other site 1266738005015 heme binding pocket [chemical binding]; other site 1266738005016 NADPH binding site [chemical binding]; other site 1266738005017 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 1266738005018 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1266738005019 acyl-activating enzyme (AAE) consensus motif; other site 1266738005020 putative AMP binding site [chemical binding]; other site 1266738005021 putative active site [active] 1266738005022 putative CoA binding site [chemical binding]; other site 1266738005023 O-succinylbenzoate synthase; Provisional; Region: PRK05105 1266738005024 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1266738005025 active site 1266738005026 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1266738005027 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1266738005028 substrate binding site [chemical binding]; other site 1266738005029 oxyanion hole (OAH) forming residues; other site 1266738005030 trimer interface [polypeptide binding]; other site 1266738005031 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 1266738005032 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1266738005033 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1266738005034 dimer interface [polypeptide binding]; other site 1266738005035 tetramer interface [polypeptide binding]; other site 1266738005036 PYR/PP interface [polypeptide binding]; other site 1266738005037 TPP binding site [chemical binding]; other site 1266738005038 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1266738005039 TPP-binding site; other site 1266738005040 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1266738005041 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1266738005042 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1266738005043 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1266738005044 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1266738005045 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1266738005046 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1266738005047 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1266738005048 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1266738005049 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1266738005050 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1266738005051 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1266738005052 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1266738005053 4Fe-4S binding domain; Region: Fer4; pfam00037 1266738005054 4Fe-4S binding domain; Region: Fer4; pfam00037 1266738005055 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1266738005056 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1266738005057 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1266738005058 catalytic loop [active] 1266738005059 iron binding site [ion binding]; other site 1266738005060 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1266738005061 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1266738005062 [4Fe-4S] binding site [ion binding]; other site 1266738005063 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1266738005064 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1266738005065 SLBB domain; Region: SLBB; pfam10531 1266738005066 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1266738005067 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1266738005068 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1266738005069 putative dimer interface [polypeptide binding]; other site 1266738005070 [2Fe-2S] cluster binding site [ion binding]; other site 1266738005071 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1266738005072 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1266738005073 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1266738005074 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1266738005075 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1266738005076 aminotransferase AlaT; Validated; Region: PRK09265 1266738005077 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1266738005078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738005079 homodimer interface [polypeptide binding]; other site 1266738005080 catalytic residue [active] 1266738005081 5'-nucleotidase; Provisional; Region: PRK03826 1266738005082 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1266738005083 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1266738005084 TrkA-C domain; Region: TrkA_C; pfam02080 1266738005085 TrkA-C domain; Region: TrkA_C; pfam02080 1266738005086 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1266738005087 putative phosphatase; Provisional; Region: PRK11587 1266738005088 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1266738005089 motif II; other site 1266738005090 hypothetical protein; Provisional; Region: PRK01816 1266738005091 propionate/acetate kinase; Provisional; Region: PRK12379 1266738005092 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1266738005093 phosphate acetyltransferase; Reviewed; Region: PRK05632 1266738005094 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1266738005095 DRTGG domain; Region: DRTGG; pfam07085 1266738005096 phosphate acetyltransferase; Region: pta; TIGR00651 1266738005097 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1266738005098 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1266738005099 Trp docking motif [polypeptide binding]; other site 1266738005100 putative active site [active] 1266738005101 alanine racemase; Reviewed; Region: PRK13340 1266738005102 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme, Alanine Racemase 2; Region: PLPDE_III_AR2; cd06826 1266738005103 active site 1266738005104 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1266738005105 dimer interface [polypeptide binding]; other site 1266738005106 substrate binding site [chemical binding]; other site 1266738005107 catalytic residues [active] 1266738005108 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1266738005109 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1266738005110 active site 1266738005111 P-loop; other site 1266738005112 phosphorylation site [posttranslational modification] 1266738005113 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1266738005114 active site 1266738005115 phosphorylation site [posttranslational modification] 1266738005116 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1266738005117 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1266738005118 DNA binding site [nucleotide binding] 1266738005119 domain linker motif; other site 1266738005120 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1266738005121 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1266738005122 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1266738005123 nudix motif; other site 1266738005124 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1266738005125 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1266738005126 C-terminal domain interface [polypeptide binding]; other site 1266738005127 GSH binding site (G-site) [chemical binding]; other site 1266738005128 dimer interface [polypeptide binding]; other site 1266738005129 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1266738005130 N-terminal domain interface [polypeptide binding]; other site 1266738005131 putative dimer interface [polypeptide binding]; other site 1266738005132 active site 1266738005133 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1266738005134 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1266738005135 putative NAD(P) binding site [chemical binding]; other site 1266738005136 putative active site [active] 1266738005137 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1266738005138 Flavoprotein; Region: Flavoprotein; pfam02441 1266738005139 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1266738005140 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1266738005141 active site 1266738005142 tetramer interface [polypeptide binding]; other site 1266738005143 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1266738005144 active site 1266738005145 colicin V production protein; Provisional; Region: PRK10845 1266738005146 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1266738005147 cell division protein DedD; Provisional; Region: PRK11633 1266738005148 Sporulation related domain; Region: SPOR; pfam05036 1266738005149 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1266738005150 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1266738005151 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1266738005152 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1266738005153 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1266738005154 hypothetical protein; Provisional; Region: PRK10847 1266738005155 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1266738005156 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1266738005157 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1266738005158 dimerization interface 3.5A [polypeptide binding]; other site 1266738005159 active site 1266738005160 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 1266738005161 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1266738005162 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1266738005163 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1266738005164 ligand binding site [chemical binding]; other site 1266738005165 NAD binding site [chemical binding]; other site 1266738005166 catalytic site [active] 1266738005167 homodimer interface [polypeptide binding]; other site 1266738005168 Cupin domain; Region: Cupin_2; pfam07883 1266738005169 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1266738005170 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1266738005171 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1266738005172 EamA-like transporter family; Region: EamA; pfam00892 1266738005173 EamA-like transporter family; Region: EamA; pfam00892 1266738005174 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1266738005175 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1266738005176 dimer interface [polypeptide binding]; other site 1266738005177 active site 1266738005178 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1266738005179 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1266738005180 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1266738005181 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1266738005182 Coenzyme A binding pocket [chemical binding]; other site 1266738005183 YfcL protein; Region: YfcL; pfam08891 1266738005184 Protein of unknown function, DUF462; Region: DUF462; pfam04315 1266738005185 hypothetical protein; Provisional; Region: PRK10621 1266738005186 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1266738005187 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1266738005188 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1266738005189 Tetramer interface [polypeptide binding]; other site 1266738005190 active site 1266738005191 FMN-binding site [chemical binding]; other site 1266738005192 HemK family putative methylases; Region: hemK_fam; TIGR00536 1266738005193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738005194 S-adenosylmethionine binding site [chemical binding]; other site 1266738005195 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1266738005196 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1266738005197 dimerization interface [polypeptide binding]; other site 1266738005198 DPS ferroxidase diiron center [ion binding]; other site 1266738005199 ion pore; other site 1266738005200 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1266738005201 catalytic core [active] 1266738005202 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1266738005203 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1266738005204 substrate binding site [chemical binding]; other site 1266738005205 oxyanion hole (OAH) forming residues; other site 1266738005206 trimer interface [polypeptide binding]; other site 1266738005207 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1266738005208 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1266738005209 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1266738005210 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1266738005211 dimer interface [polypeptide binding]; other site 1266738005212 active site 1266738005213 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1266738005214 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 1266738005215 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1266738005216 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1266738005217 thiosulfate reductase PhsA; Provisional; Region: PRK15488 1266738005218 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 1266738005219 putative [Fe4-S4] binding site [ion binding]; other site 1266738005220 putative molybdopterin cofactor binding site [chemical binding]; other site 1266738005221 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 1266738005222 putative molybdopterin cofactor binding site; other site 1266738005223 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1266738005224 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 1266738005225 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1266738005226 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1266738005227 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738005228 non-specific DNA binding site [nucleotide binding]; other site 1266738005229 salt bridge; other site 1266738005230 sequence-specific DNA binding site [nucleotide binding]; other site 1266738005231 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1266738005232 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1266738005233 HIGH motif; other site 1266738005234 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1266738005235 active site 1266738005236 KMSKS motif; other site 1266738005237 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1266738005238 classical (c) SDRs; Region: SDR_c; cd05233 1266738005239 NAD(P) binding site [chemical binding]; other site 1266738005240 active site 1266738005241 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1266738005242 MarR family; Region: MarR_2; pfam12802 1266738005243 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 1266738005244 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1266738005245 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1266738005246 Nucleoside recognition; Region: Gate; pfam07670 1266738005247 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1266738005248 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1266738005249 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1266738005250 nucleotide binding pocket [chemical binding]; other site 1266738005251 K-X-D-G motif; other site 1266738005252 catalytic site [active] 1266738005253 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1266738005254 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1266738005255 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1266738005256 Dimer interface [polypeptide binding]; other site 1266738005257 BRCT sequence motif; other site 1266738005258 cell division protein ZipA; Provisional; Region: PRK03427 1266738005259 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1266738005260 FtsZ protein binding site [polypeptide binding]; other site 1266738005261 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1266738005262 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1266738005263 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1266738005264 dimer interface [polypeptide binding]; other site 1266738005265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738005266 catalytic residue [active] 1266738005267 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1266738005268 dimerization domain swap beta strand [polypeptide binding]; other site 1266738005269 regulatory protein interface [polypeptide binding]; other site 1266738005270 active site 1266738005271 regulatory phosphorylation site [posttranslational modification]; other site 1266738005272 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1266738005273 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1266738005274 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1266738005275 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1266738005276 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1266738005277 HPr interaction site; other site 1266738005278 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1266738005279 active site 1266738005280 phosphorylation site [posttranslational modification] 1266738005281 cysteine synthase B; Region: cysM; TIGR01138 1266738005282 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1266738005283 dimer interface [polypeptide binding]; other site 1266738005284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738005285 catalytic residue [active] 1266738005286 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 1266738005287 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1266738005288 Walker A/P-loop; other site 1266738005289 ATP binding site [chemical binding]; other site 1266738005290 Q-loop/lid; other site 1266738005291 ABC transporter signature motif; other site 1266738005292 Walker B; other site 1266738005293 D-loop; other site 1266738005294 H-loop/switch region; other site 1266738005295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738005296 dimer interface [polypeptide binding]; other site 1266738005297 conserved gate region; other site 1266738005298 putative PBP binding loops; other site 1266738005299 ABC-ATPase subunit interface; other site 1266738005300 sulfate transport protein; Provisional; Region: cysT; CHL00187 1266738005301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738005302 dimer interface [polypeptide binding]; other site 1266738005303 conserved gate region; other site 1266738005304 putative PBP binding loops; other site 1266738005305 ABC-ATPase subunit interface; other site 1266738005306 thiosulfate transporter subunit; Provisional; Region: PRK10852 1266738005307 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1266738005308 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1266738005309 putative acetyltransferase; Provisional; Region: PRK03624 1266738005310 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1266738005311 Coenzyme A binding pocket [chemical binding]; other site 1266738005312 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1266738005313 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1266738005314 GTP-binding protein Der; Reviewed; Region: PRK00093 1266738005315 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1266738005316 G1 box; other site 1266738005317 GTP/Mg2+ binding site [chemical binding]; other site 1266738005318 Switch I region; other site 1266738005319 G2 box; other site 1266738005320 Switch II region; other site 1266738005321 G3 box; other site 1266738005322 G4 box; other site 1266738005323 G5 box; other site 1266738005324 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1266738005325 G1 box; other site 1266738005326 GTP/Mg2+ binding site [chemical binding]; other site 1266738005327 Switch I region; other site 1266738005328 G2 box; other site 1266738005329 G3 box; other site 1266738005330 Switch II region; other site 1266738005331 G4 box; other site 1266738005332 G5 box; other site 1266738005333 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1266738005334 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 1266738005335 Trp docking motif [polypeptide binding]; other site 1266738005336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1266738005337 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1266738005338 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1266738005339 dimer interface [polypeptide binding]; other site 1266738005340 motif 1; other site 1266738005341 active site 1266738005342 motif 2; other site 1266738005343 motif 3; other site 1266738005344 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1266738005345 anticodon binding site; other site 1266738005346 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1266738005347 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1266738005348 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1266738005349 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1266738005350 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738005351 non-specific DNA binding site [nucleotide binding]; other site 1266738005352 salt bridge; other site 1266738005353 sequence-specific DNA binding site [nucleotide binding]; other site 1266738005354 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1266738005355 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1266738005356 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1266738005357 FeS/SAM binding site; other site 1266738005358 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1266738005359 active site 1266738005360 multimer interface [polypeptide binding]; other site 1266738005361 penicillin-binding protein 1C; Provisional; Region: PRK11240 1266738005362 Transglycosylase; Region: Transgly; pfam00912 1266738005363 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cl00322 1266738005364 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1266738005365 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1266738005366 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1266738005367 MG2 domain; Region: A2M_N; pfam01835 1266738005368 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1266738005369 surface patch; other site 1266738005370 thioester region; other site 1266738005371 specificity defining residues; other site 1266738005372 SseB protein; Region: SseB; cl06279 1266738005373 aminopeptidase B; Provisional; Region: PRK05015 1266738005374 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1266738005375 interface (dimer of trimers) [polypeptide binding]; other site 1266738005376 Substrate-binding/catalytic site; other site 1266738005377 Zn-binding sites [ion binding]; other site 1266738005378 Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123 1266738005379 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1266738005380 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1266738005381 catalytic loop [active] 1266738005382 iron binding site [ion binding]; other site 1266738005383 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1266738005384 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1266738005385 nucleotide binding site [chemical binding]; other site 1266738005386 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1266738005387 SBD interface [polypeptide binding]; other site 1266738005388 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1266738005389 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1266738005390 HSP70 interaction site [polypeptide binding]; other site 1266738005391 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1266738005392 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1266738005393 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1266738005394 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1266738005395 trimerization site [polypeptide binding]; other site 1266738005396 active site 1266738005397 cysteine desulfurase; Provisional; Region: PRK14012 1266738005398 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1266738005399 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1266738005400 catalytic residue [active] 1266738005401 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 1266738005402 Rrf2 family protein; Region: rrf2_super; TIGR00738 1266738005403 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1266738005404 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1266738005405 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1266738005406 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1266738005407 active site 1266738005408 dimerization interface [polypeptide binding]; other site 1266738005409 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1266738005410 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1266738005411 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1266738005412 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1266738005413 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1266738005414 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1266738005415 active site 1266738005416 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1266738005417 MFS_1 like family; Region: MFS_1_like; pfam12832 1266738005418 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1266738005419 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1266738005420 dimer interface [polypeptide binding]; other site 1266738005421 active site 1266738005422 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1266738005423 folate binding site [chemical binding]; other site 1266738005424 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1266738005425 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1266738005426 heme-binding site [chemical binding]; other site 1266738005427 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1266738005428 FAD binding pocket [chemical binding]; other site 1266738005429 FAD binding motif [chemical binding]; other site 1266738005430 phosphate binding motif [ion binding]; other site 1266738005431 beta-alpha-beta structure motif; other site 1266738005432 NAD binding pocket [chemical binding]; other site 1266738005433 Heme binding pocket [chemical binding]; other site 1266738005434 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1266738005435 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1266738005436 NAD synthetase; Provisional; Region: PRK13981 1266738005437 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1266738005438 multimer interface [polypeptide binding]; other site 1266738005439 active site 1266738005440 catalytic triad [active] 1266738005441 protein interface 1 [polypeptide binding]; other site 1266738005442 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1266738005443 homodimer interface [polypeptide binding]; other site 1266738005444 NAD binding pocket [chemical binding]; other site 1266738005445 ATP binding pocket [chemical binding]; other site 1266738005446 Mg binding site [ion binding]; other site 1266738005447 active-site loop [active] 1266738005448 response regulator GlrR; Provisional; Region: PRK15115 1266738005449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738005450 active site 1266738005451 phosphorylation site [posttranslational modification] 1266738005452 intermolecular recognition site; other site 1266738005453 dimerization interface [polypeptide binding]; other site 1266738005454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1266738005455 Walker A motif; other site 1266738005456 ATP binding site [chemical binding]; other site 1266738005457 Walker B motif; other site 1266738005458 arginine finger; other site 1266738005459 hypothetical protein; Provisional; Region: PRK10722 1266738005460 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1266738005461 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1266738005462 dimerization interface [polypeptide binding]; other site 1266738005463 ATP binding site [chemical binding]; other site 1266738005464 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1266738005465 dimerization interface [polypeptide binding]; other site 1266738005466 ATP binding site [chemical binding]; other site 1266738005467 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1266738005468 putative active site [active] 1266738005469 catalytic triad [active] 1266738005470 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1266738005471 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1266738005472 substrate binding pocket [chemical binding]; other site 1266738005473 membrane-bound complex binding site; other site 1266738005474 hinge residues; other site 1266738005475 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1266738005476 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1266738005477 catalytic residue [active] 1266738005478 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1266738005479 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 1266738005480 PapC N-terminal domain; Region: PapC_N; pfam13954 1266738005481 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1266738005482 PapC C-terminal domain; Region: PapC_C; pfam13953 1266738005483 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1266738005484 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1266738005485 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1266738005486 Fimbrial protein; Region: Fimbrial; pfam00419 1266738005487 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1266738005488 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1266738005489 nucleoside/Zn binding site; other site 1266738005490 dimer interface [polypeptide binding]; other site 1266738005491 catalytic motif [active] 1266738005492 ferredoxin; Validated; Region: PRK07118 1266738005493 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1266738005494 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1266738005495 active site 1266738005496 hydrophilic channel; other site 1266738005497 dimerization interface [polypeptide binding]; other site 1266738005498 catalytic residues [active] 1266738005499 active site lid [active] 1266738005500 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1266738005501 Recombination protein O N terminal; Region: RecO_N; pfam11967 1266738005502 Recombination protein O C terminal; Region: RecO_C; pfam02565 1266738005503 GTPase Era; Reviewed; Region: era; PRK00089 1266738005504 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1266738005505 G1 box; other site 1266738005506 GTP/Mg2+ binding site [chemical binding]; other site 1266738005507 Switch I region; other site 1266738005508 G2 box; other site 1266738005509 Switch II region; other site 1266738005510 G3 box; other site 1266738005511 G4 box; other site 1266738005512 G5 box; other site 1266738005513 KH domain; Region: KH_2; pfam07650 1266738005514 ribonuclease III; Reviewed; Region: rnc; PRK00102 1266738005515 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1266738005516 dimerization interface [polypeptide binding]; other site 1266738005517 active site 1266738005518 metal binding site [ion binding]; metal-binding site 1266738005519 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1266738005520 dsRNA binding site [nucleotide binding]; other site 1266738005521 signal peptidase I; Provisional; Region: PRK10861 1266738005522 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1266738005523 Catalytic site [active] 1266738005524 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1266738005525 GTP-binding protein LepA; Provisional; Region: PRK05433 1266738005526 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1266738005527 G1 box; other site 1266738005528 putative GEF interaction site [polypeptide binding]; other site 1266738005529 GTP/Mg2+ binding site [chemical binding]; other site 1266738005530 Switch I region; other site 1266738005531 G2 box; other site 1266738005532 G3 box; other site 1266738005533 Switch II region; other site 1266738005534 G4 box; other site 1266738005535 G5 box; other site 1266738005536 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1266738005537 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1266738005538 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1266738005539 SoxR reducing system protein RseC; Provisional; Region: PRK10862 1266738005540 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1266738005541 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1266738005542 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1266738005543 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1266738005544 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1266738005545 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 1266738005546 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1266738005547 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1266738005548 DNA binding residues [nucleotide binding] 1266738005549 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1266738005550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738005551 S-adenosylmethionine binding site [chemical binding]; other site 1266738005552 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1266738005553 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1266738005554 ATP binding site [chemical binding]; other site 1266738005555 Mg++ binding site [ion binding]; other site 1266738005556 motif III; other site 1266738005557 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1266738005558 nucleotide binding region [chemical binding]; other site 1266738005559 ATP-binding site [chemical binding]; other site 1266738005560 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1266738005561 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1266738005562 ligand binding site [chemical binding]; other site 1266738005563 active site 1266738005564 UGI interface [polypeptide binding]; other site 1266738005565 catalytic site [active] 1266738005566 GrpE; Region: GrpE; pfam01025 1266738005567 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1266738005568 dimer interface [polypeptide binding]; other site 1266738005569 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1266738005570 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1266738005571 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1266738005572 recombination and repair protein; Provisional; Region: PRK10869 1266738005573 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1266738005574 Walker A/P-loop; other site 1266738005575 ATP binding site [chemical binding]; other site 1266738005576 Q-loop/lid; other site 1266738005577 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1266738005578 ABC transporter signature motif; other site 1266738005579 Walker B; other site 1266738005580 D-loop; other site 1266738005581 H-loop/switch region; other site 1266738005582 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1266738005583 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1266738005584 hypothetical protein; Validated; Region: PRK01777 1266738005585 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1266738005586 putative coenzyme Q binding site [chemical binding]; other site 1266738005587 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1266738005588 SmpB-tmRNA interface; other site 1266738005589 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1266738005590 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1266738005591 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1266738005592 active site 1266738005593 Int/Topo IB signature motif; other site 1266738005594 EamA-like transporter family; Region: EamA; pfam00892 1266738005595 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1266738005596 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1266738005597 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1266738005598 DNA-binding site [nucleotide binding]; DNA binding site 1266738005599 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1266738005600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738005601 homodimer interface [polypeptide binding]; other site 1266738005602 catalytic residue [active] 1266738005603 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1266738005604 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1266738005605 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1266738005606 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1266738005607 Cupin domain; Region: Cupin_2; pfam07883 1266738005608 malate:quinone oxidoreductase; Validated; Region: PRK05257 1266738005609 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1266738005610 Membrane transport protein; Region: Mem_trans; cl09117 1266738005611 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1266738005612 catalytic core [active] 1266738005613 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1266738005614 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1266738005615 L-lactate permease; Region: Lactate_perm; cl00701 1266738005616 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1266738005617 Cysteine-rich domain; Region: CCG; pfam02754 1266738005618 Cysteine-rich domain; Region: CCG; pfam02754 1266738005619 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1266738005620 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1266738005621 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1266738005622 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1266738005623 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1266738005624 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1266738005625 Protein of unknown function, DUF486; Region: DUF486; cl01236 1266738005626 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1266738005627 Domain of unknown function (DUF1287); Region: DUF1287; pfam06940 1266738005628 putative MFS family transporter protein; Provisional; Region: PRK03633 1266738005629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738005630 putative substrate translocation pore; other site 1266738005631 putative iron-regulated outer membrane virulence protein; Provisional; Region: PRK13484 1266738005632 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1266738005633 N-terminal plug; other site 1266738005634 ligand-binding site [chemical binding]; other site 1266738005635 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 1266738005636 putative transporter; Provisional; Region: PRK10484 1266738005637 Na binding site [ion binding]; other site 1266738005638 substrate binding site [chemical binding]; other site 1266738005639 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 1266738005640 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1266738005641 DNA binding site [nucleotide binding] 1266738005642 domain linker motif; other site 1266738005643 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1266738005644 dimerization interface (closed form) [polypeptide binding]; other site 1266738005645 ligand binding site [chemical binding]; other site 1266738005646 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1266738005647 active site 1266738005648 catalytic residues [active] 1266738005649 galactokinase; Provisional; Region: PRK05101 1266738005650 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1266738005651 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1266738005652 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1266738005653 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1266738005654 dimer interface [polypeptide binding]; other site 1266738005655 active site 1266738005656 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1266738005657 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1266738005658 dimerization interface [polypeptide binding]; other site 1266738005659 ligand binding site [chemical binding]; other site 1266738005660 NADP binding site [chemical binding]; other site 1266738005661 catalytic site [active] 1266738005662 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1266738005663 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1266738005664 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1266738005665 Ligand Binding Site [chemical binding]; other site 1266738005666 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cl00178 1266738005667 secondary substrate binding site; other site 1266738005668 primary substrate binding site; other site 1266738005669 inhibition loop; other site 1266738005670 dimerization interface [polypeptide binding]; other site 1266738005671 Protein of unknown function (DUF465); Region: DUF465; cl01070 1266738005672 probable metal-binding protein; Region: matur_matur; TIGR03853 1266738005673 DinI-like family; Region: DinI; cl11630 1266738005674 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 1266738005675 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1266738005676 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1266738005677 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1266738005678 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1266738005679 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1266738005680 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1266738005681 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1266738005682 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1266738005683 Predicted flavoprotein [General function prediction only]; Region: COG0431 1266738005684 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1266738005685 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1266738005686 dimer interface [polypeptide binding]; other site 1266738005687 putative anticodon binding site; other site 1266738005688 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1266738005689 motif 1; other site 1266738005690 active site 1266738005691 motif 2; other site 1266738005692 motif 3; other site 1266738005693 peptide chain release factor 2; Provisional; Region: PRK08787 1266738005694 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1266738005695 RF-1 domain; Region: RF-1; pfam00472 1266738005696 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1266738005697 DHH family; Region: DHH; pfam01368 1266738005698 DHHA1 domain; Region: DHHA1; pfam02272 1266738005699 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1266738005700 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1266738005701 dimerization domain [polypeptide binding]; other site 1266738005702 dimer interface [polypeptide binding]; other site 1266738005703 catalytic residues [active] 1266738005704 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1266738005705 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1266738005706 active site 1266738005707 Int/Topo IB signature motif; other site 1266738005708 flavodoxin FldB; Provisional; Region: PRK12359 1266738005709 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 1266738005710 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 1266738005711 putative global regulator; Reviewed; Region: PRK09559 1266738005712 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1266738005713 HD domain; Region: HD_3; pfam13023 1266738005714 glycine dehydrogenase; Provisional; Region: PRK05367 1266738005715 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1266738005716 tetramer interface [polypeptide binding]; other site 1266738005717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738005718 catalytic residue [active] 1266738005719 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1266738005720 tetramer interface [polypeptide binding]; other site 1266738005721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738005722 catalytic residue [active] 1266738005723 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1266738005724 lipoyl attachment site [posttranslational modification]; other site 1266738005725 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1266738005726 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1266738005727 oxidoreductase; Provisional; Region: PRK08013 1266738005728 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1266738005729 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1266738005730 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 1266738005731 proline aminopeptidase P II; Provisional; Region: PRK10879 1266738005732 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1266738005733 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1266738005734 active site 1266738005735 hypothetical protein; Reviewed; Region: PRK01736 1266738005736 Z-ring-associated protein; Provisional; Region: PRK10972 1266738005737 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1266738005738 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1266738005739 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 1266738005740 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1266738005741 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738005742 Walker A/P-loop; other site 1266738005743 ATP binding site [chemical binding]; other site 1266738005744 Q-loop/lid; other site 1266738005745 ABC transporter signature motif; other site 1266738005746 Walker B; other site 1266738005747 D-loop; other site 1266738005748 H-loop/switch region; other site 1266738005749 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1266738005750 HlyD family secretion protein; Region: HlyD_3; pfam13437 1266738005751 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1266738005752 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 1266738005753 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1266738005754 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738005755 Walker A/P-loop; other site 1266738005756 ATP binding site [chemical binding]; other site 1266738005757 Q-loop/lid; other site 1266738005758 ABC transporter signature motif; other site 1266738005759 Walker B; other site 1266738005760 D-loop; other site 1266738005761 H-loop/switch region; other site 1266738005762 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1266738005763 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1266738005764 ligand binding site [chemical binding]; other site 1266738005765 NAD binding site [chemical binding]; other site 1266738005766 tetramer interface [polypeptide binding]; other site 1266738005767 catalytic site [active] 1266738005768 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1266738005769 L-serine binding site [chemical binding]; other site 1266738005770 ACT domain interface; other site 1266738005771 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1266738005772 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1266738005773 active site 1266738005774 dimer interface [polypeptide binding]; other site 1266738005775 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1266738005776 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738005777 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1266738005778 putative dimerization interface [polypeptide binding]; other site 1266738005779 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1266738005780 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1266738005781 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1266738005782 oxidative stress defense protein; Provisional; Region: PRK11087 1266738005783 arginine exporter protein; Provisional; Region: PRK09304 1266738005784 mechanosensitive channel MscS; Provisional; Region: PRK10334 1266738005785 Conserved TM helix; Region: TM_helix; pfam05552 1266738005786 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1266738005787 hypothetical protein; Provisional; Region: PRK05248 1266738005788 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1266738005789 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1266738005790 substrate binding site [chemical binding]; other site 1266738005791 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1266738005792 substrate binding site [chemical binding]; other site 1266738005793 ligand binding site [chemical binding]; other site 1266738005794 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1266738005795 C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647 1266738005796 C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647 1266738005797 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1266738005798 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1266738005799 Peptidase C80 family; Region: Peptidase_C80; pfam11713 1266738005800 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1266738005801 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1266738005802 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1266738005803 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1266738005804 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1266738005805 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1266738005806 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1266738005807 E3 interaction surface; other site 1266738005808 lipoyl attachment site [posttranslational modification]; other site 1266738005809 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1266738005810 E3 interaction surface; other site 1266738005811 lipoyl attachment site [posttranslational modification]; other site 1266738005812 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1266738005813 E3 interaction surface; other site 1266738005814 lipoyl attachment site [posttranslational modification]; other site 1266738005815 e3 binding domain; Region: E3_binding; pfam02817 1266738005816 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1266738005817 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1266738005818 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1266738005819 dimer interface [polypeptide binding]; other site 1266738005820 TPP-binding site [chemical binding]; other site 1266738005821 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1266738005822 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1266738005823 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1266738005824 DNA-binding site [nucleotide binding]; DNA binding site 1266738005825 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1266738005826 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1266738005827 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1266738005828 amidase catalytic site [active] 1266738005829 substrate binding site [chemical binding]; other site 1266738005830 Zn binding residues [ion binding]; other site 1266738005831 putative major pilin subunit; Provisional; Region: PRK10574 1266738005832 Type II/IV secretion system protein; Region: T2SE; pfam00437 1266738005833 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1266738005834 Walker A motif; other site 1266738005835 ATP binding site [chemical binding]; other site 1266738005836 Walker B motif; other site 1266738005837 type IV pilin biogenesis protein; Provisional; Region: PRK10573 1266738005838 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1266738005839 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1266738005840 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1266738005841 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1266738005842 CoA-binding site [chemical binding]; other site 1266738005843 ATP-binding [chemical binding]; other site 1266738005844 hypothetical protein; Provisional; Region: PRK05287 1266738005845 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1266738005846 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1266738005847 active site 1266738005848 8-oxo-dGMP binding site [chemical binding]; other site 1266738005849 nudix motif; other site 1266738005850 metal binding site [ion binding]; metal-binding site 1266738005851 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1266738005852 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1266738005853 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1266738005854 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1266738005855 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1266738005856 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1266738005857 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1266738005858 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1266738005859 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1266738005860 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1266738005861 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1266738005862 metal-binding site [ion binding] 1266738005863 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1266738005864 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1266738005865 metal-binding site [ion binding] 1266738005866 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1266738005867 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1266738005868 motif II; other site 1266738005869 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1266738005870 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1266738005871 DNA binding residues [nucleotide binding] 1266738005872 dimer interface [polypeptide binding]; other site 1266738005873 copper binding site [ion binding]; other site 1266738005874 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1266738005875 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1266738005876 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1266738005877 nucleotide binding region [chemical binding]; other site 1266738005878 ATP-binding site [chemical binding]; other site 1266738005879 SEC-C motif; Region: SEC-C; pfam02810 1266738005880 Protein of unknown function (DUF721); Region: DUF721; cl02324 1266738005881 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1266738005882 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1266738005883 cell division protein FtsZ; Validated; Region: PRK09330 1266738005884 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1266738005885 nucleotide binding site [chemical binding]; other site 1266738005886 SulA interaction site; other site 1266738005887 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1266738005888 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1266738005889 Cell division protein FtsA; Region: FtsA; pfam14450 1266738005890 cell division protein FtsQ; Provisional; Region: PRK10775 1266738005891 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1266738005892 Cell division protein FtsQ; Region: FtsQ; pfam03799 1266738005893 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1266738005894 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1266738005895 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1266738005896 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1266738005897 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1266738005898 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1266738005899 active site 1266738005900 homodimer interface [polypeptide binding]; other site 1266738005901 cell division protein FtsW; Provisional; Region: PRK10774 1266738005902 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1266738005903 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1266738005904 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1266738005905 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1266738005906 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1266738005907 Mg++ binding site [ion binding]; other site 1266738005908 putative catalytic motif [active] 1266738005909 putative substrate binding site [chemical binding]; other site 1266738005910 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1266738005911 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1266738005912 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1266738005913 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1266738005914 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1266738005915 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1266738005916 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1266738005917 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1266738005918 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1266738005919 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1266738005920 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1266738005921 cell division protein FtsL; Provisional; Region: PRK10772 1266738005922 MraW methylase family; Region: Methyltransf_5; pfam01795 1266738005923 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1266738005924 cell division protein MraZ; Reviewed; Region: PRK00326 1266738005925 MraZ protein; Region: MraZ; pfam02381 1266738005926 MraZ protein; Region: MraZ; pfam02381 1266738005927 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1266738005928 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1266738005929 DNA binding site [nucleotide binding] 1266738005930 domain linker motif; other site 1266738005931 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1266738005932 dimerization interface [polypeptide binding]; other site 1266738005933 ligand binding site [chemical binding]; other site 1266738005934 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1266738005935 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1266738005936 acyl-activating enzyme (AAE) consensus motif; other site 1266738005937 putative AMP binding site [chemical binding]; other site 1266738005938 putative active site [active] 1266738005939 putative CoA binding site [chemical binding]; other site 1266738005940 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1266738005941 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738005942 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 1266738005943 putative substrate binding pocket [chemical binding]; other site 1266738005944 putative dimerization interface [polypeptide binding]; other site 1266738005945 2-isopropylmalate synthase; Validated; Region: PRK00915 1266738005946 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1266738005947 active site 1266738005948 catalytic residues [active] 1266738005949 metal binding site [ion binding]; metal-binding site 1266738005950 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1266738005951 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1266738005952 tartrate dehydrogenase; Region: TTC; TIGR02089 1266738005953 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1266738005954 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1266738005955 substrate binding site [chemical binding]; other site 1266738005956 ligand binding site [chemical binding]; other site 1266738005957 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1266738005958 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1266738005959 substrate binding site [chemical binding]; other site 1266738005960 transcriptional regulator SgrR; Provisional; Region: PRK13626 1266738005961 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1266738005962 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1266738005963 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1266738005964 putative DNA-binding cleft [nucleotide binding]; other site 1266738005965 putative DNA clevage site; other site 1266738005966 molecular lever; other site 1266738005967 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1266738005968 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1266738005969 acetoin reductases; Region: 23BDH; TIGR02415 1266738005970 NAD binding site [chemical binding]; other site 1266738005971 homotetramer interface [polypeptide binding]; other site 1266738005972 homodimer interface [polypeptide binding]; other site 1266738005973 active site 1266738005974 substrate binding site [chemical binding]; other site 1266738005975 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1266738005976 agmatinase; Region: agmatinase; TIGR01230 1266738005977 oligomer interface [polypeptide binding]; other site 1266738005978 putative active site [active] 1266738005979 Mn binding site [ion binding]; other site 1266738005980 arginine decarboxylase; Provisional; Region: PRK05354 1266738005981 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1266738005982 dimer interface [polypeptide binding]; other site 1266738005983 active site 1266738005984 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1266738005985 catalytic residues [active] 1266738005986 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1266738005987 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1266738005988 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1266738005989 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1266738005990 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1266738005991 Protein of unknown function (DUF3260); Region: DUF3260; cl11881 1266738005992 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 1266738005993 YhjQ protein; Region: YhjQ; pfam06564 1266738005994 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 1266738005995 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1266738005996 DXD motif; other site 1266738005997 PilZ domain; Region: PilZ; pfam07238 1266738005998 cellulose synthase regulator protein; Provisional; Region: PRK11114 1266738005999 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1266738006000 binding surface 1266738006001 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1266738006002 TPR motif; other site 1266738006003 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1266738006004 TPR motif; other site 1266738006005 binding surface 1266738006006 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1266738006007 Predicted transporter component [General function prediction only]; Region: COG2391 1266738006008 Sulphur transport; Region: Sulf_transp; pfam04143 1266738006009 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 1266738006010 Predicted transporter component [General function prediction only]; Region: COG2391 1266738006011 Sulphur transport; Region: Sulf_transp; pfam04143 1266738006012 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1266738006013 dimerization interface [polypeptide binding]; other site 1266738006014 putative DNA binding site [nucleotide binding]; other site 1266738006015 putative Zn2+ binding site [ion binding]; other site 1266738006016 hypothetical protein; Provisional; Region: PRK04860 1266738006017 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1266738006018 Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; pfam13957 1266738006019 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1266738006020 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1266738006021 Divalent cation transporter; Region: MgtE; pfam01769 1266738006022 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 1266738006023 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1266738006024 FAD binding pocket [chemical binding]; other site 1266738006025 FAD binding motif [chemical binding]; other site 1266738006026 phosphate binding motif [ion binding]; other site 1266738006027 beta-alpha-beta structure motif; other site 1266738006028 NAD binding pocket [chemical binding]; other site 1266738006029 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1266738006030 catalytic loop [active] 1266738006031 iron binding site [ion binding]; other site 1266738006032 hybrid cluster protein; Provisional; Region: PRK05290 1266738006033 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1266738006034 ACS interaction site; other site 1266738006035 CODH interaction site; other site 1266738006036 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1266738006037 hybrid metal cluster; other site 1266738006038 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1266738006039 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1266738006040 NAD(P) binding site [chemical binding]; other site 1266738006041 catalytic residues [active] 1266738006042 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1266738006043 amino acid carrier protein; Region: agcS; TIGR00835 1266738006044 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1266738006045 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1266738006046 Cl- selectivity filter; other site 1266738006047 Cl- binding residues [ion binding]; other site 1266738006048 pore gating glutamate residue; other site 1266738006049 dimer interface [polypeptide binding]; other site 1266738006050 H+/Cl- coupling transport residue; other site 1266738006051 tellurite resistance protein TehB; Provisional; Region: PRK12335 1266738006052 Domain of unknown function (DUF1971); Region: DUF1971; pfam09313 1266738006053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738006054 S-adenosylmethionine binding site [chemical binding]; other site 1266738006055 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 1266738006056 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1266738006057 hypothetical protein; Provisional; Region: PRK03757 1266738006058 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1266738006059 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1266738006060 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1266738006061 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1266738006062 putative active site [active] 1266738006063 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 1266738006064 trimer interface [polypeptide binding]; other site 1266738006065 YadA-like C-terminal region; Region: YadA; pfam03895 1266738006066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1266738006067 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 1266738006068 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1266738006069 Sulfatase; Region: Sulfatase; cl17466 1266738006070 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1266738006071 Lyase, N terminal; Region: Lyase_N; pfam09092 1266738006072 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 1266738006073 substrate binding site [chemical binding]; other site 1266738006074 catalytic residues [active] 1266738006075 Lyase, N terminal; Region: Lyase_N; pfam09092 1266738006076 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl17706 1266738006077 substrate binding site [chemical binding]; other site 1266738006078 catalytic residues [active] 1266738006079 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1266738006080 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK12481 1266738006081 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1266738006082 NADP binding site [chemical binding]; other site 1266738006083 homodimer interface [polypeptide binding]; other site 1266738006084 active site 1266738006085 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1266738006086 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1266738006087 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1266738006088 active site 1266738006089 dimer interface [polypeptide binding]; other site 1266738006090 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1266738006091 active pocket/dimerization site; other site 1266738006092 active site 1266738006093 phosphorylation site [posttranslational modification] 1266738006094 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1266738006095 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1266738006096 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1266738006097 active site 1266738006098 phosphorylation site [posttranslational modification] 1266738006099 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 1266738006100 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1266738006101 dimer interface [polypeptide binding]; other site 1266738006102 active site 1266738006103 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 1266738006104 putative active site [active] 1266738006105 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 1266738006106 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1266738006107 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1266738006108 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1266738006109 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1266738006110 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1266738006111 FeS/SAM binding site; other site 1266738006112 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1266738006113 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1266738006114 Sulfatase; Region: Sulfatase; pfam00884 1266738006115 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 1266738006116 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1266738006117 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1266738006118 intersubunit interface [polypeptide binding]; other site 1266738006119 active site 1266738006120 zinc binding site [ion binding]; other site 1266738006121 Na+ binding site [ion binding]; other site 1266738006122 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1266738006123 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1266738006124 substrate binding site [chemical binding]; other site 1266738006125 ATP binding site [chemical binding]; other site 1266738006126 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1266738006127 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1266738006128 active site 1266738006129 intersubunit interface [polypeptide binding]; other site 1266738006130 catalytic residue [active] 1266738006131 DJ-1 family protein; Region: not_thiJ; TIGR01383 1266738006132 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1266738006133 conserved cys residue [active] 1266738006134 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1266738006135 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1266738006136 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1266738006137 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1266738006138 arsenical pump membrane protein; Provisional; Region: PRK15445 1266738006139 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1266738006140 transmembrane helices; other site 1266738006141 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1266738006142 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1266738006143 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1266738006144 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1266738006145 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1266738006146 active site 1266738006147 DNA binding site [nucleotide binding] 1266738006148 Int/Topo IB signature motif; other site 1266738006149 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1266738006150 putative chaperone protein EcpD; Provisional; Region: PRK09926 1266738006151 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1266738006152 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1266738006153 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1266738006154 PapC N-terminal domain; Region: PapC_N; pfam13954 1266738006155 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1266738006156 PapC C-terminal domain; Region: PapC_C; pfam13953 1266738006157 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1266738006158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738006159 sequence-specific DNA binding site [nucleotide binding]; other site 1266738006160 salt bridge; other site 1266738006161 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1266738006162 Interdomain contacts; other site 1266738006163 Cytokine receptor motif; other site 1266738006164 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1266738006165 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1266738006166 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1266738006167 tape measure domain; Region: tape_meas_nterm; TIGR02675 1266738006168 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 1266738006169 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 1266738006170 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1266738006171 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 1266738006172 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1266738006173 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 1266738006174 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1266738006175 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 1266738006176 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1266738006177 Phage capsid family; Region: Phage_capsid; pfam05065 1266738006178 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 1266738006179 Phage-related protein [Function unknown]; Region: COG4695 1266738006180 Phage portal protein; Region: Phage_portal; pfam04860 1266738006181 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1266738006182 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1266738006183 KTSC domain; Region: KTSC; pfam13619 1266738006184 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1266738006185 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1266738006186 catalytic residues [active] 1266738006187 Oligosaccharyl transferase STT3 subunit; Region: STT3; pfam02516 1266738006188 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1266738006189 DNA-binding site [nucleotide binding]; DNA binding site 1266738006190 RNA-binding motif; other site 1266738006191 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 1266738006192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1266738006193 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 1266738006194 Toprim domain; Region: Toprim_3; pfam13362 1266738006195 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1266738006196 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1266738006197 ATP binding site [chemical binding]; other site 1266738006198 putative Mg++ binding site [ion binding]; other site 1266738006199 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1266738006200 nucleotide binding region [chemical binding]; other site 1266738006201 ATP-binding site [chemical binding]; other site 1266738006202 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1266738006203 Cro; Region: Cro; pfam09048 1266738006204 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1266738006205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738006206 sequence-specific DNA binding site [nucleotide binding]; other site 1266738006207 salt bridge; other site 1266738006208 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1266738006209 Catalytic site [active] 1266738006210 ATP-dependent protease La; Region: lon; TIGR00763 1266738006211 cell division protein MukB; Provisional; Region: mukB; PRK04863 1266738006212 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1266738006213 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1266738006214 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1266738006215 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1266738006216 homodimer interface [polypeptide binding]; other site 1266738006217 NADP binding site [chemical binding]; other site 1266738006218 substrate binding site [chemical binding]; other site 1266738006219 ribosome-associated protein; Provisional; Region: PRK11507 1266738006220 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1266738006221 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1266738006222 putative substrate binding site [chemical binding]; other site 1266738006223 putative ATP binding site [chemical binding]; other site 1266738006224 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1266738006225 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1266738006226 active site 1266738006227 HIGH motif; other site 1266738006228 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1266738006229 KMSKS motif; other site 1266738006230 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1266738006231 tRNA binding surface [nucleotide binding]; other site 1266738006232 anticodon binding site; other site 1266738006233 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1266738006234 substrate binding site [chemical binding]; other site 1266738006235 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1266738006236 putative active site [active] 1266738006237 putative metal binding site [ion binding]; other site 1266738006238 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1266738006239 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1266738006240 ATP-grasp domain; Region: ATP-grasp; pfam02222 1266738006241 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1266738006242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738006243 putative substrate translocation pore; other site 1266738006244 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1266738006245 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1266738006246 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1266738006247 FtsX-like permease family; Region: FtsX; pfam02687 1266738006248 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 1266738006249 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1266738006250 Walker A/P-loop; other site 1266738006251 ATP binding site [chemical binding]; other site 1266738006252 Q-loop/lid; other site 1266738006253 ABC transporter signature motif; other site 1266738006254 Walker B; other site 1266738006255 D-loop; other site 1266738006256 H-loop/switch region; other site 1266738006257 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1266738006258 active site 1266738006259 catalytic triad [active] 1266738006260 oxyanion hole [active] 1266738006261 switch loop; other site 1266738006262 oxidoreductase; Provisional; Region: PRK08017 1266738006263 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1266738006264 NADP binding site [chemical binding]; other site 1266738006265 active site 1266738006266 steroid binding site; other site 1266738006267 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1266738006268 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1266738006269 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1266738006270 TPR motif; other site 1266738006271 binding surface 1266738006272 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1266738006273 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1266738006274 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1266738006275 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1266738006276 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1266738006277 DNA binding residues [nucleotide binding] 1266738006278 dimer interface [polypeptide binding]; other site 1266738006279 copper binding site [ion binding]; other site 1266738006280 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1266738006281 metal-binding site [ion binding] 1266738006282 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1266738006283 copper exporting ATPase; Provisional; Region: copA; PRK10671 1266738006284 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1266738006285 metal-binding site [ion binding] 1266738006286 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1266738006287 metal-binding site [ion binding] 1266738006288 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1266738006289 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1266738006290 motif II; other site 1266738006291 YadA-like C-terminal region; Region: YadA; pfam03895 1266738006292 TraB family; Region: TraB; cl12050 1266738006293 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1266738006294 putative deacylase active site [active] 1266738006295 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1266738006296 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1266738006297 active site 1266738006298 metal binding site [ion binding]; metal-binding site 1266738006299 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1266738006300 putative cation:proton antiport protein; Provisional; Region: PRK10669 1266738006301 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1266738006302 TrkA-N domain; Region: TrkA_N; pfam02254 1266738006303 inosine/guanosine kinase; Provisional; Region: PRK15074 1266738006304 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1266738006305 substrate binding site [chemical binding]; other site 1266738006306 ATP binding site [chemical binding]; other site 1266738006307 LPS O-antigen length regulator; Provisional; Region: PRK10381 1266738006308 Chain length determinant protein; Region: Wzz; pfam02706 1266738006309 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1266738006310 ferrochelatase; Reviewed; Region: hemH; PRK00035 1266738006311 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1266738006312 C-terminal domain interface [polypeptide binding]; other site 1266738006313 active site 1266738006314 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1266738006315 active site 1266738006316 N-terminal domain interface [polypeptide binding]; other site 1266738006317 adenylate kinase; Reviewed; Region: adk; PRK00279 1266738006318 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1266738006319 AMP-binding site [chemical binding]; other site 1266738006320 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1266738006321 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1266738006322 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1266738006323 ATP-grasp domain; Region: ATP-grasp; pfam02222 1266738006324 EamA-like transporter family; Region: EamA; cl17759 1266738006325 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1266738006326 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1266738006327 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1266738006328 putative substrate binding site [chemical binding]; other site 1266738006329 putative ATP binding site [chemical binding]; other site 1266738006330 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1266738006331 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1266738006332 substrate binding [chemical binding]; other site 1266738006333 active site 1266738006334 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1266738006335 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1266738006336 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1266738006337 DNA binding site [nucleotide binding] 1266738006338 domain linker motif; other site 1266738006339 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 1266738006340 putative ligand binding site [chemical binding]; other site 1266738006341 putative dimerization interface [polypeptide binding]; other site 1266738006342 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1266738006343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738006344 active site 1266738006345 dimerization interface [polypeptide binding]; other site 1266738006346 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1266738006347 DNA binding residues [nucleotide binding] 1266738006348 dimerization interface [polypeptide binding]; other site 1266738006349 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1266738006350 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1266738006351 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1266738006352 putative acyl-acceptor binding pocket; other site 1266738006353 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 1266738006354 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1266738006355 CAAX protease self-immunity; Region: Abi; pfam02517 1266738006356 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 1266738006357 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738006358 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1266738006359 dimerization interface [polypeptide binding]; other site 1266738006360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738006361 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1266738006362 putative substrate translocation pore; other site 1266738006363 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1266738006364 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1266738006365 putative substrate binding site [chemical binding]; other site 1266738006366 nucleotide binding site [chemical binding]; other site 1266738006367 nucleotide binding site [chemical binding]; other site 1266738006368 homodimer interface [polypeptide binding]; other site 1266738006369 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1266738006370 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1266738006371 membrane protein FdrA; Validated; Region: PRK06091 1266738006372 CoA binding domain; Region: CoA_binding; pfam02629 1266738006373 CoA-ligase; Region: Ligase_CoA; pfam00549 1266738006374 Isochorismatase family; Region: Isochorismatase; pfam00857 1266738006375 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1266738006376 catalytic triad [active] 1266738006377 dimer interface [polypeptide binding]; other site 1266738006378 conserved cis-peptide bond; other site 1266738006379 Pirin-related protein [General function prediction only]; Region: COG1741 1266738006380 Pirin; Region: Pirin; pfam02678 1266738006381 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1266738006382 LysR family transcriptional regulator; Provisional; Region: PRK14997 1266738006383 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738006384 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1266738006385 putative effector binding pocket; other site 1266738006386 putative dimerization interface [polypeptide binding]; other site 1266738006387 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1266738006388 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1266738006389 transmembrane helices; other site 1266738006390 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1266738006391 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738006392 non-specific DNA binding site [nucleotide binding]; other site 1266738006393 salt bridge; other site 1266738006394 sequence-specific DNA binding site [nucleotide binding]; other site 1266738006395 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1266738006396 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1266738006397 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738006398 non-specific DNA binding site [nucleotide binding]; other site 1266738006399 salt bridge; other site 1266738006400 sequence-specific DNA binding site [nucleotide binding]; other site 1266738006401 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1266738006402 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1266738006403 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1266738006404 PapC N-terminal domain; Region: PapC_N; pfam13954 1266738006405 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1266738006406 PapC C-terminal domain; Region: PapC_C; pfam13953 1266738006407 putative chaperone protein EcpD; Provisional; Region: PRK09926 1266738006408 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1266738006409 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1266738006410 Fimbrial protein; Region: Fimbrial; cl01416 1266738006411 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1266738006412 Fimbrial protein; Region: Fimbrial; pfam00419 1266738006413 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1266738006414 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1266738006415 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1266738006416 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1266738006417 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 1266738006418 PapC N-terminal domain; Region: PapC_N; pfam13954 1266738006419 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1266738006420 PapC C-terminal domain; Region: PapC_C; pfam13953 1266738006421 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1266738006422 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1266738006423 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738006424 sequence-specific DNA binding site [nucleotide binding]; other site 1266738006425 salt bridge; other site 1266738006426 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1266738006427 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1266738006428 active site 1266738006429 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1266738006430 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1266738006431 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1266738006432 active site turn [active] 1266738006433 phosphorylation site [posttranslational modification] 1266738006434 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1266738006435 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1266738006436 HPr interaction site; other site 1266738006437 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1266738006438 active site 1266738006439 phosphorylation site [posttranslational modification] 1266738006440 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1266738006441 CAT RNA binding domain; Region: CAT_RBD; smart01061 1266738006442 PRD domain; Region: PRD; pfam00874 1266738006443 PRD domain; Region: PRD; pfam00874 1266738006444 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1266738006445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1266738006446 Coenzyme A binding pocket [chemical binding]; other site 1266738006447 Fic/DOC family; Region: Fic; pfam02661 1266738006448 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1266738006449 nudix motif; other site 1266738006450 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1266738006451 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1266738006452 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1266738006453 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1266738006454 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1266738006455 DNA binding residues [nucleotide binding] 1266738006456 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1266738006457 Peptidase family M23; Region: Peptidase_M23; pfam01551 1266738006458 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1266738006459 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1266738006460 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1266738006461 Permutation of conserved domain; other site 1266738006462 active site 1266738006463 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1266738006464 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1266738006465 homotrimer interaction site [polypeptide binding]; other site 1266738006466 zinc binding site [ion binding]; other site 1266738006467 CDP-binding sites; other site 1266738006468 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1266738006469 substrate binding site; other site 1266738006470 dimer interface; other site 1266738006471 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1266738006472 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1266738006473 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1266738006474 ligand-binding site [chemical binding]; other site 1266738006475 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1266738006476 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1266738006477 CysD dimerization site [polypeptide binding]; other site 1266738006478 G1 box; other site 1266738006479 putative GEF interaction site [polypeptide binding]; other site 1266738006480 GTP/Mg2+ binding site [chemical binding]; other site 1266738006481 Switch I region; other site 1266738006482 G2 box; other site 1266738006483 G3 box; other site 1266738006484 Switch II region; other site 1266738006485 G4 box; other site 1266738006486 G5 box; other site 1266738006487 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1266738006488 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1266738006489 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1266738006490 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1266738006491 Active Sites [active] 1266738006492 siroheme synthase; Provisional; Region: cysG; PRK10637 1266738006493 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1266738006494 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1266738006495 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1266738006496 active site 1266738006497 SAM binding site [chemical binding]; other site 1266738006498 homodimer interface [polypeptide binding]; other site 1266738006499 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1266738006500 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1266738006501 Active Sites [active] 1266738006502 sulfite reductase subunit beta; Provisional; Region: PRK13504 1266738006503 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1266738006504 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1266738006505 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1266738006506 Flavodoxin; Region: Flavodoxin_1; pfam00258 1266738006507 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1266738006508 FAD binding pocket [chemical binding]; other site 1266738006509 FAD binding motif [chemical binding]; other site 1266738006510 catalytic residues [active] 1266738006511 NAD binding pocket [chemical binding]; other site 1266738006512 phosphate binding motif [ion binding]; other site 1266738006513 beta-alpha-beta structure motif; other site 1266738006514 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1266738006515 active site 1266738006516 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1266738006517 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1266738006518 putative proline-specific permease; Provisional; Region: proY; PRK10580 1266738006519 methionine gamma-lyase; Provisional; Region: PRK07503 1266738006520 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1266738006521 homodimer interface [polypeptide binding]; other site 1266738006522 substrate-cofactor binding pocket; other site 1266738006523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738006524 catalytic residue [active] 1266738006525 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1266738006526 hypothetical protein; Provisional; Region: PRK05421 1266738006527 putative phosphate binding site [ion binding]; other site 1266738006528 putative catalytic site [active] 1266738006529 putative phosphate binding site [ion binding]; other site 1266738006530 putative metal binding site [ion binding]; other site 1266738006531 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1266738006532 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1266738006533 active site 1266738006534 motif I; other site 1266738006535 motif II; other site 1266738006536 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1266738006537 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1266738006538 Walker A/P-loop; other site 1266738006539 ATP binding site [chemical binding]; other site 1266738006540 Q-loop/lid; other site 1266738006541 ABC transporter signature motif; other site 1266738006542 Walker B; other site 1266738006543 D-loop; other site 1266738006544 H-loop/switch region; other site 1266738006545 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1266738006546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738006547 dimer interface [polypeptide binding]; other site 1266738006548 conserved gate region; other site 1266738006549 ABC-ATPase subunit interface; other site 1266738006550 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1266738006551 lipoprotein, YaeC family; Region: TIGR00363 1266738006552 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1266738006553 homodimer interaction site [polypeptide binding]; other site 1266738006554 cofactor binding site; other site 1266738006555 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1266738006556 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1266738006557 dimer interface [polypeptide binding]; other site 1266738006558 motif 1; other site 1266738006559 active site 1266738006560 motif 2; other site 1266738006561 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1266738006562 putative deacylase active site [active] 1266738006563 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1266738006564 active site 1266738006565 motif 3; other site 1266738006566 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1266738006567 anticodon binding site; other site 1266738006568 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 1266738006569 NlpE N-terminal domain; Region: NlpE; pfam04170 1266738006570 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 1266738006571 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1266738006572 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1266738006573 Ligand Binding Site [chemical binding]; other site 1266738006574 TilS substrate binding domain; Region: TilS; pfam09179 1266738006575 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1266738006576 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1266738006577 classical (c) SDRs; Region: SDR_c; cd05233 1266738006578 NAD(P) binding site [chemical binding]; other site 1266738006579 active site 1266738006580 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1266738006581 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1266738006582 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1266738006583 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1266738006584 putative active site [active] 1266738006585 putative PHP Thumb interface [polypeptide binding]; other site 1266738006586 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1266738006587 generic binding surface II; other site 1266738006588 generic binding surface I; other site 1266738006589 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1266738006590 RNA/DNA hybrid binding site [nucleotide binding]; other site 1266738006591 active site 1266738006592 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1266738006593 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1266738006594 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1266738006595 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1266738006596 active site 1266738006597 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1266738006598 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1266738006599 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1266738006600 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1266738006601 trimer interface [polypeptide binding]; other site 1266738006602 active site 1266738006603 UDP-GlcNAc binding site [chemical binding]; other site 1266738006604 lipid binding site [chemical binding]; lipid-binding site 1266738006605 periplasmic chaperone; Provisional; Region: PRK10780 1266738006606 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1266738006607 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1266738006608 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1266738006609 active site 1266738006610 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1266738006611 protein binding site [polypeptide binding]; other site 1266738006612 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1266738006613 protein binding site [polypeptide binding]; other site 1266738006614 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1266738006615 putative substrate binding region [chemical binding]; other site 1266738006616 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1266738006617 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1266738006618 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1266738006619 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1266738006620 catalytic residue [active] 1266738006621 putative FPP diphosphate binding site; other site 1266738006622 putative FPP binding hydrophobic cleft; other site 1266738006623 dimer interface [polypeptide binding]; other site 1266738006624 putative IPP diphosphate binding site; other site 1266738006625 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1266738006626 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1266738006627 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1266738006628 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1266738006629 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1266738006630 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1266738006631 hinge region; other site 1266738006632 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1266738006633 putative nucleotide binding site [chemical binding]; other site 1266738006634 uridine monophosphate binding site [chemical binding]; other site 1266738006635 homohexameric interface [polypeptide binding]; other site 1266738006636 elongation factor Ts; Provisional; Region: tsf; PRK09377 1266738006637 UBA/TS-N domain; Region: UBA; pfam00627 1266738006638 Elongation factor TS; Region: EF_TS; pfam00889 1266738006639 Elongation factor TS; Region: EF_TS; pfam00889 1266738006640 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1266738006641 rRNA interaction site [nucleotide binding]; other site 1266738006642 S8 interaction site; other site 1266738006643 putative laminin-1 binding site; other site 1266738006644 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1266738006645 active site 1266738006646 PII uridylyl-transferase; Provisional; Region: PRK05007 1266738006647 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1266738006648 metal binding triad; other site 1266738006649 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1266738006650 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1266738006651 Zn2+ binding site [ion binding]; other site 1266738006652 Mg2+ binding site [ion binding]; other site 1266738006653 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1266738006654 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1266738006655 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1266738006656 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1266738006657 trimer interface [polypeptide binding]; other site 1266738006658 active site 1266738006659 substrate binding site [chemical binding]; other site 1266738006660 CoA binding site [chemical binding]; other site 1266738006661 hypothetical protein; Provisional; Region: PRK13677 1266738006662 flavodoxin; Provisional; Region: PRK08105 1266738006663 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1266738006664 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1266738006665 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1266738006666 active site turn [active] 1266738006667 phosphorylation site [posttranslational modification] 1266738006668 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1266738006669 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1266738006670 probable active site [active] 1266738006671 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 1266738006672 SecY interacting protein Syd; Provisional; Region: PRK04968 1266738006673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1266738006674 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1266738006675 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1266738006676 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1266738006677 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1266738006678 flap endonuclease-like protein; Provisional; Region: PRK09482 1266738006679 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1266738006680 active site 1266738006681 metal binding site 1 [ion binding]; metal-binding site 1266738006682 putative 5' ssDNA interaction site; other site 1266738006683 metal binding site 3; metal-binding site 1266738006684 metal binding site 2 [ion binding]; metal-binding site 1266738006685 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1266738006686 putative DNA binding site [nucleotide binding]; other site 1266738006687 putative metal binding site [ion binding]; other site 1266738006688 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1266738006689 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1266738006690 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1266738006691 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738006692 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1266738006693 dimerization interface [polypeptide binding]; other site 1266738006694 substrate binding pocket [chemical binding]; other site 1266738006695 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1266738006696 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1266738006697 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1266738006698 catalytic residue [active] 1266738006699 Fe-S metabolism associated domain; Region: SufE; cl00951 1266738006700 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1266738006701 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1266738006702 putative ATP binding site [chemical binding]; other site 1266738006703 putative substrate interface [chemical binding]; other site 1266738006704 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1266738006705 MltA specific insert domain; Region: MltA; pfam03562 1266738006706 3D domain; Region: 3D; pfam06725 1266738006707 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1266738006708 AMIN domain; Region: AMIN; pfam11741 1266738006709 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1266738006710 active site 1266738006711 metal binding site [ion binding]; metal-binding site 1266738006712 N-acetylglutamate synthase; Validated; Region: PRK05279 1266738006713 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1266738006714 putative feedback inhibition sensing region; other site 1266738006715 putative nucleotide binding site [chemical binding]; other site 1266738006716 putative substrate binding site [chemical binding]; other site 1266738006717 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1266738006718 Coenzyme A binding pocket [chemical binding]; other site 1266738006719 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1266738006720 AAA domain; Region: AAA_30; pfam13604 1266738006721 Family description; Region: UvrD_C_2; pfam13538 1266738006722 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1266738006723 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1266738006724 protease3; Provisional; Region: PRK15101 1266738006725 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1266738006726 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1266738006727 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1266738006728 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 1266738006729 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1266738006730 hypothetical protein; Provisional; Region: PRK10557 1266738006731 hypothetical protein; Provisional; Region: PRK10506 1266738006732 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1266738006733 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1266738006734 dimerization interface [polypeptide binding]; other site 1266738006735 active site 1266738006736 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1266738006737 GAF domain; Region: GAF; pfam01590 1266738006738 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1266738006739 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1266738006740 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1266738006741 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1266738006742 putative active site [active] 1266738006743 Ap4A binding site [chemical binding]; other site 1266738006744 nudix motif; other site 1266738006745 putative metal binding site [ion binding]; other site 1266738006746 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1266738006747 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1266738006748 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1266738006749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738006750 dimer interface [polypeptide binding]; other site 1266738006751 conserved gate region; other site 1266738006752 putative PBP binding loops; other site 1266738006753 ABC-ATPase subunit interface; other site 1266738006754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738006755 dimer interface [polypeptide binding]; other site 1266738006756 conserved gate region; other site 1266738006757 putative PBP binding loops; other site 1266738006758 ABC-ATPase subunit interface; other site 1266738006759 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 1266738006760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738006761 Walker A/P-loop; other site 1266738006762 ATP binding site [chemical binding]; other site 1266738006763 Q-loop/lid; other site 1266738006764 ABC transporter signature motif; other site 1266738006765 Walker B; other site 1266738006766 D-loop; other site 1266738006767 H-loop/switch region; other site 1266738006768 Helix-turn-helix domain; Region: HTH_17; pfam12728 1266738006769 PIN domain; Region: PIN_3; pfam13470 1266738006770 DNA polymerase II; Reviewed; Region: PRK05762 1266738006771 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1266738006772 active site 1266738006773 catalytic site [active] 1266738006774 substrate binding site [chemical binding]; other site 1266738006775 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1266738006776 active site 1266738006777 metal-binding site 1266738006778 ATP-dependent helicase HepA; Validated; Region: PRK04914 1266738006779 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1266738006780 ATP binding site [chemical binding]; other site 1266738006781 putative Mg++ binding site [ion binding]; other site 1266738006782 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1266738006783 nucleotide binding region [chemical binding]; other site 1266738006784 ATP-binding site [chemical binding]; other site 1266738006785 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1266738006786 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1266738006787 active site 1266738006788 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1266738006789 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1266738006790 putative metal binding site [ion binding]; other site 1266738006791 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1266738006792 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1266738006793 OstA-like protein; Region: OstA; pfam03968 1266738006794 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1266738006795 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1266738006796 SurA N-terminal domain; Region: SurA_N; pfam09312 1266738006797 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1266738006798 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1266738006799 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1266738006800 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1266738006801 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1266738006802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738006803 S-adenosylmethionine binding site [chemical binding]; other site 1266738006804 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1266738006805 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1266738006806 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1266738006807 active site 1266738006808 metal binding site [ion binding]; metal-binding site 1266738006809 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1266738006810 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1266738006811 folate binding site [chemical binding]; other site 1266738006812 NADP+ binding site [chemical binding]; other site 1266738006813 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1266738006814 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1266738006815 Probable transposase; Region: OrfB_IS605; pfam01385 1266738006816 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1266738006817 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 1266738006818 catalytic triad [active] 1266738006819 putative active site [active] 1266738006820 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1266738006821 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1266738006822 FtsI repressor; Provisional; Region: PRK10883 1266738006823 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1266738006824 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1266738006825 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1266738006826 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1266738006827 CAP-like domain; other site 1266738006828 active site 1266738006829 primary dimer interface [polypeptide binding]; other site 1266738006830 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1266738006831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1266738006832 ATP binding site [chemical binding]; other site 1266738006833 Mg2+ binding site [ion binding]; other site 1266738006834 G-X-G motif; other site 1266738006835 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1266738006836 anchoring element; other site 1266738006837 dimer interface [polypeptide binding]; other site 1266738006838 ATP binding site [chemical binding]; other site 1266738006839 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1266738006840 active site 1266738006841 metal binding site [ion binding]; metal-binding site 1266738006842 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1266738006843 esterase YqiA; Provisional; Region: PRK11071 1266738006844 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1266738006845 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1266738006846 active site 1266738006847 metal binding site [ion binding]; metal-binding site 1266738006848 hexamer interface [polypeptide binding]; other site 1266738006849 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1266738006850 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1266738006851 dimer interface [polypeptide binding]; other site 1266738006852 ADP-ribose binding site [chemical binding]; other site 1266738006853 active site 1266738006854 nudix motif; other site 1266738006855 metal binding site [ion binding]; metal-binding site 1266738006856 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1266738006857 hypothetical protein; Provisional; Region: PRK11653 1266738006858 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1266738006859 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1266738006860 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1266738006861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1266738006862 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1266738006863 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1266738006864 putative ribose interaction site [chemical binding]; other site 1266738006865 putative ADP binding site [chemical binding]; other site 1266738006866 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1266738006867 active site 1266738006868 nucleotide binding site [chemical binding]; other site 1266738006869 HIGH motif; other site 1266738006870 KMSKS motif; other site 1266738006871 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1266738006872 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1266738006873 metal binding triad; other site 1266738006874 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1266738006875 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1266738006876 metal binding triad; other site 1266738006877 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1266738006878 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1266738006879 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1266738006880 putative active site [active] 1266738006881 putative metal binding residues [ion binding]; other site 1266738006882 signature motif; other site 1266738006883 putative triphosphate binding site [ion binding]; other site 1266738006884 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1266738006885 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1266738006886 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1266738006887 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1266738006888 active site 1266738006889 NTP binding site [chemical binding]; other site 1266738006890 metal binding triad [ion binding]; metal-binding site 1266738006891 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1266738006892 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1266738006893 Zn2+ binding site [ion binding]; other site 1266738006894 Mg2+ binding site [ion binding]; other site 1266738006895 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1266738006896 homooctamer interface [polypeptide binding]; other site 1266738006897 active site 1266738006898 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1266738006899 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1266738006900 Prephenate dehydratase; Region: PDT; pfam00800 1266738006901 Cupin domain; Region: Cupin_2; pfam07883 1266738006902 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1266738006903 UGMP family protein; Validated; Region: PRK09604 1266738006904 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1266738006905 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1266738006906 DNA primase; Validated; Region: dnaG; PRK05667 1266738006907 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1266738006908 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1266738006909 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1266738006910 active site 1266738006911 metal binding site [ion binding]; metal-binding site 1266738006912 interdomain interaction site; other site 1266738006913 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1266738006914 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1266738006915 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1266738006916 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1266738006917 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1266738006918 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1266738006919 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1266738006920 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1266738006921 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1266738006922 DNA binding residues [nucleotide binding] 1266738006923 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1266738006924 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1266738006925 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1266738006926 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1266738006927 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1266738006928 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1266738006929 putative molybdopterin cofactor binding site [chemical binding]; other site 1266738006930 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1266738006931 putative molybdopterin cofactor binding site; other site 1266738006932 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1266738006933 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738006934 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1266738006935 dimerization interface [polypeptide binding]; other site 1266738006936 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1266738006937 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1266738006938 dimer interface [polypeptide binding]; other site 1266738006939 putative CheW interface [polypeptide binding]; other site 1266738006940 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1266738006941 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1266738006942 dimer interface [polypeptide binding]; other site 1266738006943 putative CheW interface [polypeptide binding]; other site 1266738006944 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1266738006945 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1266738006946 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1266738006947 putative metal binding site [ion binding]; other site 1266738006948 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1266738006949 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1266738006950 putative metal binding site [ion binding]; other site 1266738006951 Integral membrane protein TerC family; Region: TerC; cl10468 1266738006952 tellurite resistance protein terB; Region: terB; cd07176 1266738006953 putative metal binding site [ion binding]; other site 1266738006954 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1266738006955 putative metal binding site [ion binding]; other site 1266738006956 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1266738006957 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 1266738006958 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1266738006959 putative metal binding site [ion binding]; other site 1266738006960 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1266738006961 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1266738006962 putative metal binding site [ion binding]; other site 1266738006963 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1266738006964 active site 1266738006965 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 1266738006966 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1266738006967 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 1266738006968 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1266738006969 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1266738006970 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1266738006971 nudix motif; other site 1266738006972 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1266738006973 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 1266738006974 NADH kinase; Region: PLN02929 1266738006975 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1266738006976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1266738006977 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1266738006978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738006979 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1266738006980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738006981 Phage holin family 2; Region: Phage_holin_2; pfam04550 1266738006982 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1266738006983 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 1266738006984 Dak1 domain; Region: Dak1; pfam02733 1266738006985 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 1266738006986 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 1266738006987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 1266738006988 active site 1266738006989 active pocket/dimerization site; other site 1266738006990 phosphorylation site [posttranslational modification] 1266738006991 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1266738006992 dimerization domain swap beta strand [polypeptide binding]; other site 1266738006993 regulatory protein interface [polypeptide binding]; other site 1266738006994 active site 1266738006995 regulatory phosphorylation site [posttranslational modification]; other site 1266738006996 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1266738006997 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1266738006998 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1266738006999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738007000 active site 1266738007001 phosphorylation site [posttranslational modification] 1266738007002 intermolecular recognition site; other site 1266738007003 dimerization interface [polypeptide binding]; other site 1266738007004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1266738007005 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1266738007006 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 1266738007007 HAMP domain; Region: HAMP; pfam00672 1266738007008 dimerization interface [polypeptide binding]; other site 1266738007009 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1266738007010 dimer interface [polypeptide binding]; other site 1266738007011 phosphorylation site [posttranslational modification] 1266738007012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1266738007013 ATP binding site [chemical binding]; other site 1266738007014 Mg2+ binding site [ion binding]; other site 1266738007015 G-X-G motif; other site 1266738007016 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1266738007017 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1266738007018 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1266738007019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738007020 putative substrate translocation pore; other site 1266738007021 pyruvate kinase; Provisional; Region: PRK05826 1266738007022 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1266738007023 domain interfaces; other site 1266738007024 active site 1266738007025 hypothetical protein; Provisional; Region: PRK11019 1266738007026 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 1266738007027 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1266738007028 catalytic residue [active] 1266738007029 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1266738007030 Citrate transporter; Region: CitMHS; pfam03600 1266738007031 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1266738007032 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1266738007033 phosphopentomutase; Provisional; Region: PRK05362 1266738007034 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1266738007035 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1266738007036 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1266738007037 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1266738007038 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1266738007039 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1266738007040 intersubunit interface [polypeptide binding]; other site 1266738007041 active site 1266738007042 catalytic residue [active] 1266738007043 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1266738007044 active site 1266738007045 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1266738007046 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1266738007047 active site 1266738007048 nucleophile elbow; other site 1266738007049 periplasmic protein; Provisional; Region: PRK10568 1266738007050 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1266738007051 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1266738007052 G1 box; other site 1266738007053 putative GEF interaction site [polypeptide binding]; other site 1266738007054 GTP/Mg2+ binding site [chemical binding]; other site 1266738007055 Switch I region; other site 1266738007056 G2 box; other site 1266738007057 G3 box; other site 1266738007058 Switch II region; other site 1266738007059 G4 box; other site 1266738007060 G5 box; other site 1266738007061 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1266738007062 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1266738007063 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1266738007064 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1266738007065 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1266738007066 Coenzyme A binding pocket [chemical binding]; other site 1266738007067 DNA polymerase III subunit psi; Validated; Region: PRK06856 1266738007068 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1266738007069 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1266738007070 Coenzyme A binding pocket [chemical binding]; other site 1266738007071 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1266738007072 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1266738007073 PhoU domain; Region: PhoU; pfam01895 1266738007074 alkaline phosphatase; Provisional; Region: PRK10518 1266738007075 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1266738007076 dimer interface [polypeptide binding]; other site 1266738007077 active site 1266738007078 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1266738007079 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1266738007080 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1266738007081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1266738007082 TPR motif; other site 1266738007083 binding surface 1266738007084 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1266738007085 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1266738007086 putative active site [active] 1266738007087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738007088 non-specific DNA binding site [nucleotide binding]; other site 1266738007089 salt bridge; other site 1266738007090 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1266738007091 sequence-specific DNA binding site [nucleotide binding]; other site 1266738007092 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1266738007093 active site 1266738007094 nucleotide binding site [chemical binding]; other site 1266738007095 HIGH motif; other site 1266738007096 KMSKS motif; other site 1266738007097 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1266738007098 DNA repair protein RadA; Provisional; Region: PRK11823 1266738007099 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1266738007100 Walker A motif/ATP binding site; other site 1266738007101 ATP binding site [chemical binding]; other site 1266738007102 Walker B motif; other site 1266738007103 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1266738007104 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1266738007105 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1266738007106 motif II; other site 1266738007107 hypothetical protein; Provisional; Region: PRK11246 1266738007108 hypothetical protein; Provisional; Region: PRK10977 1266738007109 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1266738007110 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1266738007111 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 1266738007112 FeS/SAM binding site; other site 1266738007113 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 1266738007114 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1266738007115 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1266738007116 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1266738007117 Walker A/P-loop; other site 1266738007118 ATP binding site [chemical binding]; other site 1266738007119 Q-loop/lid; other site 1266738007120 ABC transporter signature motif; other site 1266738007121 Walker B; other site 1266738007122 D-loop; other site 1266738007123 H-loop/switch region; other site 1266738007124 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1266738007125 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1266738007126 Walker A/P-loop; other site 1266738007127 ATP binding site [chemical binding]; other site 1266738007128 Q-loop/lid; other site 1266738007129 ABC transporter signature motif; other site 1266738007130 Walker B; other site 1266738007131 D-loop; other site 1266738007132 H-loop/switch region; other site 1266738007133 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1266738007134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738007135 dimer interface [polypeptide binding]; other site 1266738007136 conserved gate region; other site 1266738007137 ABC-ATPase subunit interface; other site 1266738007138 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1266738007139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738007140 dimer interface [polypeptide binding]; other site 1266738007141 conserved gate region; other site 1266738007142 putative PBP binding loops; other site 1266738007143 ABC-ATPase subunit interface; other site 1266738007144 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 1266738007145 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1266738007146 putative glycosyl transferase; Provisional; Region: PRK10073 1266738007147 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1266738007148 active site 1266738007149 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1266738007150 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 1266738007151 nickel binding site [ion binding]; other site 1266738007152 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1266738007153 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1266738007154 hydrogenase 4 subunit H; Validated; Region: PRK08222 1266738007155 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1266738007156 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1266738007157 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1266738007158 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1266738007159 hydrogenase 4 subunit F; Validated; Region: PRK06458 1266738007160 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1266738007161 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 1266738007162 hydrogenase 4 subunit D; Validated; Region: PRK06525 1266738007163 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1266738007164 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1266738007165 NADH dehydrogenase; Region: NADHdh; cl00469 1266738007166 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1266738007167 4Fe-4S binding domain; Region: Fer4; pfam00037 1266738007168 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1266738007169 elongation factor P; Validated; Region: PRK00529 1266738007170 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1266738007171 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1266738007172 RNA binding site [nucleotide binding]; other site 1266738007173 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1266738007174 RNA binding site [nucleotide binding]; other site 1266738007175 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1266738007176 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1266738007177 FeS/SAM binding site; other site 1266738007178 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1266738007179 PapC N-terminal domain; Region: PapC_N; pfam13954 1266738007180 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1266738007181 PapC C-terminal domain; Region: PapC_C; pfam13953 1266738007182 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1266738007183 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1266738007184 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1266738007185 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1266738007186 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1266738007187 Fimbrial protein; Region: Fimbrial; pfam00419 1266738007188 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1266738007189 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1266738007190 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1266738007191 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1266738007192 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1266738007193 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1266738007194 NAD(P) binding site [chemical binding]; other site 1266738007195 putative active site [active] 1266738007196 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1266738007197 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1266738007198 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1266738007199 ring oligomerisation interface [polypeptide binding]; other site 1266738007200 ATP/Mg binding site [chemical binding]; other site 1266738007201 stacking interactions; other site 1266738007202 hinge regions; other site 1266738007203 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1266738007204 oligomerisation interface [polypeptide binding]; other site 1266738007205 mobile loop; other site 1266738007206 roof hairpin; other site 1266738007207 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1266738007208 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1266738007209 Aspartase; Region: Aspartase; cd01357 1266738007210 active sites [active] 1266738007211 tetramer interface [polypeptide binding]; other site 1266738007212 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1266738007213 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1266738007214 putative transcriptional regulator; Provisional; Region: PRK11640 1266738007215 Repair protein; Region: Repair_PSII; pfam04536 1266738007216 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1266738007217 ATPase involved in DNA repair; Region: DUF3686; pfam12458 1266738007218 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 1266738007219 putative YPXnL-motif binding site; other site 1266738007220 AAA domain; Region: AAA_22; pfam13401 1266738007221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1266738007222 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1266738007223 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1266738007224 ferredoxin-like protein FixX; Provisional; Region: PRK15449 1266738007225 oxidoreductase; Provisional; Region: PRK10015 1266738007226 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1266738007227 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 1266738007228 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1266738007229 Ligand Binding Site [chemical binding]; other site 1266738007230 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1266738007231 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1266738007232 Ligand binding site [chemical binding]; other site 1266738007233 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1266738007234 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1266738007235 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1266738007236 active site 1266738007237 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 1266738007238 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1266738007239 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 1266738007240 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 1266738007241 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1266738007242 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1266738007243 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1266738007244 AMP-binding domain protein; Validated; Region: PRK08315 1266738007245 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1266738007246 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1266738007247 acyl-activating enzyme (AAE) consensus motif; other site 1266738007248 acyl-activating enzyme (AAE) consensus motif; other site 1266738007249 putative AMP binding site [chemical binding]; other site 1266738007250 putative active site [active] 1266738007251 putative CoA binding site [chemical binding]; other site 1266738007252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738007253 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1266738007254 putative substrate translocation pore; other site 1266738007255 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1266738007256 putative oxidoreductase FixC; Provisional; Region: PRK10157 1266738007257 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 1266738007258 Electron transfer flavoprotein domain; Region: ETF; smart00893 1266738007259 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1266738007260 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1266738007261 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1266738007262 Ligand binding site [chemical binding]; other site 1266738007263 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 1266738007264 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 1266738007265 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1266738007266 active site 1266738007267 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 1266738007268 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1266738007269 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 1266738007270 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1266738007271 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1266738007272 acyl-activating enzyme (AAE) consensus motif; other site 1266738007273 putative AMP binding site [chemical binding]; other site 1266738007274 putative active site [active] 1266738007275 putative CoA binding site [chemical binding]; other site 1266738007276 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 1266738007277 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1266738007278 substrate binding site [chemical binding]; other site 1266738007279 oxyanion hole (OAH) forming residues; other site 1266738007280 trimer interface [polypeptide binding]; other site 1266738007281 carnitine operon protein CaiE; Provisional; Region: PRK13627 1266738007282 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 1266738007283 putative trimer interface [polypeptide binding]; other site 1266738007284 putative metal binding site [ion binding]; other site 1266738007285 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 1266738007286 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1266738007287 active site 1266738007288 intersubunit interactions; other site 1266738007289 catalytic residue [active] 1266738007290 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1266738007291 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1266738007292 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1266738007293 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1266738007294 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1266738007295 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 1266738007296 Family description; Region: VCBS; pfam13517 1266738007297 Family description; Region: VCBS; pfam13517 1266738007298 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 1266738007299 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 1266738007300 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538 1266738007301 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1266738007302 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738007303 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1266738007304 Surface antigen; Region: Bac_surface_Ag; pfam01103 1266738007305 Protein of unknown function (DUF4056); Region: DUF4056; pfam13265 1266738007306 hypothetical protein; Provisional; Region: PRK10356 1266738007307 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 1266738007308 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1266738007309 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 1266738007310 active site 1266738007311 catalytic triad [active] 1266738007312 oxyanion hole [active] 1266738007313 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1266738007314 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 1266738007315 active site 1266738007316 oxyanion hole [active] 1266738007317 catalytic triad [active] 1266738007318 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1266738007319 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1266738007320 dimer interface [polypeptide binding]; other site 1266738007321 putative CheW interface [polypeptide binding]; other site 1266738007322 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1266738007323 low affinity gluconate transporter; Provisional; Region: PRK10472 1266738007324 gluconate transporter; Region: gntP; TIGR00791 1266738007325 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1266738007326 AAA domain; Region: AAA_33; pfam13671 1266738007327 ATP-binding site [chemical binding]; other site 1266738007328 Gluconate-6-phosphate binding site [chemical binding]; other site 1266738007329 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1266738007330 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1266738007331 DNA binding site [nucleotide binding] 1266738007332 domain linker motif; other site 1266738007333 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1266738007334 putative ligand binding site [chemical binding]; other site 1266738007335 putative dimerization interface [polypeptide binding]; other site 1266738007336 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 1266738007337 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1266738007338 putative metal binding site [ion binding]; other site 1266738007339 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1266738007340 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1266738007341 ABC-ATPase subunit interface; other site 1266738007342 dimer interface [polypeptide binding]; other site 1266738007343 putative PBP binding regions; other site 1266738007344 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1266738007345 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1266738007346 Walker A/P-loop; other site 1266738007347 ATP binding site [chemical binding]; other site 1266738007348 Q-loop/lid; other site 1266738007349 ABC transporter signature motif; other site 1266738007350 Walker B; other site 1266738007351 D-loop; other site 1266738007352 H-loop/switch region; other site 1266738007353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738007354 S-adenosylmethionine binding site [chemical binding]; other site 1266738007355 molybdenum transport protein ModD; Provisional; Region: PRK06096 1266738007356 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 1266738007357 dimerization interface [polypeptide binding]; other site 1266738007358 active site 1266738007359 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1266738007360 N-terminal plug; other site 1266738007361 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1266738007362 ligand-binding site [chemical binding]; other site 1266738007363 Invasion plasmid antigen IpaD; Region: IpaD; cl05827 1266738007364 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 1266738007365 chaperone protein SicA; Provisional; Region: PRK15331 1266738007366 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1266738007367 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1266738007368 type III secretion system protein SpaS; Validated; Region: PRK08156 1266738007369 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1266738007370 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 1266738007371 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 1266738007372 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1266738007373 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1266738007374 ATP synthase SpaL; Validated; Region: PRK08149 1266738007375 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1266738007376 Walker A motif; other site 1266738007377 ATP binding site [chemical binding]; other site 1266738007378 Walker B motif; other site 1266738007379 Invasion protein B family; Region: Invas_SpaK; cl04129 1266738007380 type III secretion system protein InvA; Provisional; Region: PRK15337 1266738007381 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1266738007382 type III secretion system regulator InvE; Provisional; Region: PRK15338 1266738007383 HrpJ-like domain; Region: HrpJ; cl15454 1266738007384 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 1266738007385 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1266738007386 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1266738007387 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1266738007388 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1266738007389 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 1266738007390 Type III secretion needle MxiH like; Region: MxiH; cl09641 1266738007391 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1266738007392 Bacterial type III secretion apparatus protein (OrgA_MxiK); Region: OrgA_MxiK; cl09716 1266738007393 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1266738007394 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1266738007395 DNA binding residues [nucleotide binding] 1266738007396 dimer interface [polypeptide binding]; other site 1266738007397 [2Fe-2S] cluster binding site [ion binding]; other site 1266738007398 Predicted membrane protein [Function unknown]; Region: COG2259 1266738007399 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1266738007400 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1266738007401 HlyD family secretion protein; Region: HlyD_3; pfam13437 1266738007402 multidrug efflux protein; Reviewed; Region: PRK09579 1266738007403 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1266738007404 active site 1266738007405 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1266738007406 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1266738007407 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 1266738007408 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1266738007409 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1266738007410 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1266738007411 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1266738007412 Hexamer interface [polypeptide binding]; other site 1266738007413 Hexagonal pore residue; other site 1266738007414 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1266738007415 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1266738007416 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1266738007417 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1266738007418 dimer interface [polypeptide binding]; other site 1266738007419 active site 1266738007420 glycine loop; other site 1266738007421 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1266738007422 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 1266738007423 putative active site [active] 1266738007424 metal binding site [ion binding]; metal-binding site 1266738007425 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1266738007426 Hexamer/Pentamer interface [polypeptide binding]; other site 1266738007427 central pore; other site 1266738007428 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1266738007429 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1266738007430 putative catalytic cysteine [active] 1266738007431 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1266738007432 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1266738007433 Hexamer interface [polypeptide binding]; other site 1266738007434 Hexagonal pore residue; other site 1266738007435 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1266738007436 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1266738007437 Hexamer interface [polypeptide binding]; other site 1266738007438 Hexagonal pore residue; other site 1266738007439 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1266738007440 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1266738007441 Hexamer interface [polypeptide binding]; other site 1266738007442 Hexagonal pore residue; other site 1266738007443 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1266738007444 DNA binding site [nucleotide binding] 1266738007445 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1266738007446 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1266738007447 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 1266738007448 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1266738007449 homodimer interface [polypeptide binding]; other site 1266738007450 substrate-cofactor binding pocket; other site 1266738007451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738007452 catalytic residue [active] 1266738007453 aromatic amino acid exporter; Provisional; Region: PRK11689 1266738007454 Fimbrial protein; Region: Fimbrial; cl01416 1266738007455 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 1266738007456 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1266738007457 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1266738007458 outer membrane usher protein; Provisional; Region: PRK15193 1266738007459 PapC N-terminal domain; Region: PapC_N; pfam13954 1266738007460 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1266738007461 PapC C-terminal domain; Region: PapC_C; pfam13953 1266738007462 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1266738007463 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1266738007464 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738007465 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1266738007466 salt bridge; other site 1266738007467 non-specific DNA binding site [nucleotide binding]; other site 1266738007468 sequence-specific DNA binding site [nucleotide binding]; other site 1266738007469 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1266738007470 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1266738007471 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1266738007472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738007473 dimer interface [polypeptide binding]; other site 1266738007474 conserved gate region; other site 1266738007475 putative PBP binding loops; other site 1266738007476 ABC-ATPase subunit interface; other site 1266738007477 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1266738007478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738007479 dimer interface [polypeptide binding]; other site 1266738007480 conserved gate region; other site 1266738007481 putative PBP binding loops; other site 1266738007482 ABC-ATPase subunit interface; other site 1266738007483 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 1266738007484 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1266738007485 Walker A/P-loop; other site 1266738007486 ATP binding site [chemical binding]; other site 1266738007487 Q-loop/lid; other site 1266738007488 ABC transporter signature motif; other site 1266738007489 Walker B; other site 1266738007490 D-loop; other site 1266738007491 H-loop/switch region; other site 1266738007492 TOBE domain; Region: TOBE_2; pfam08402 1266738007493 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1266738007494 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 1266738007495 putative active site [active] 1266738007496 putative catalytic triad [active] 1266738007497 Abi-like protein; Region: Abi_2; cl01988 1266738007498 Abi-like protein; Region: Abi_2; cl01988 1266738007499 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1266738007500 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1266738007501 FMN binding site [chemical binding]; other site 1266738007502 active site 1266738007503 catalytic residues [active] 1266738007504 substrate binding site [chemical binding]; other site 1266738007505 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1266738007506 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1266738007507 NADP binding site [chemical binding]; other site 1266738007508 dimer interface [polypeptide binding]; other site 1266738007509 replicative DNA helicase; Provisional; Region: PRK08006 1266738007510 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1266738007511 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1266738007512 Walker A motif; other site 1266738007513 ATP binding site [chemical binding]; other site 1266738007514 Walker B motif; other site 1266738007515 DNA binding loops [nucleotide binding] 1266738007516 alanine racemase; Reviewed; Region: alr; PRK00053 1266738007517 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1266738007518 active site 1266738007519 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1266738007520 substrate binding site [chemical binding]; other site 1266738007521 catalytic residues [active] 1266738007522 dimer interface [polypeptide binding]; other site 1266738007523 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1266738007524 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1266738007525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738007526 homodimer interface [polypeptide binding]; other site 1266738007527 catalytic residue [active] 1266738007528 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1266738007529 serine transporter; Region: stp; TIGR00814 1266738007530 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1266738007531 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1266738007532 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1266738007533 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1266738007534 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1266738007535 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1266738007536 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1266738007537 dimer interface [polypeptide binding]; other site 1266738007538 ssDNA binding site [nucleotide binding]; other site 1266738007539 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1266738007540 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 1266738007541 ferric uptake regulator; Provisional; Region: fur; PRK09462 1266738007542 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1266738007543 metal binding site 2 [ion binding]; metal-binding site 1266738007544 putative DNA binding helix; other site 1266738007545 metal binding site 1 [ion binding]; metal-binding site 1266738007546 dimer interface [polypeptide binding]; other site 1266738007547 structural Zn2+ binding site [ion binding]; other site 1266738007548 LexA repressor; Validated; Region: PRK00215 1266738007549 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1266738007550 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1266738007551 Catalytic site [active] 1266738007552 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1266738007553 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1266738007554 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1266738007555 putative acyl-acceptor binding pocket; other site 1266738007556 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1266738007557 UbiA prenyltransferase family; Region: UbiA; pfam01040 1266738007558 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 1266738007559 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1266738007560 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1266738007561 active site 1266738007562 dimer interface [polypeptide binding]; other site 1266738007563 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1266738007564 dimer interface [polypeptide binding]; other site 1266738007565 active site 1266738007566 aspartate kinase III; Validated; Region: PRK09084 1266738007567 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1266738007568 nucleotide binding site [chemical binding]; other site 1266738007569 substrate binding site [chemical binding]; other site 1266738007570 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1266738007571 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1266738007572 dimer interface [polypeptide binding]; other site 1266738007573 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1266738007574 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1266738007575 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1266738007576 substrate binding pocket [chemical binding]; other site 1266738007577 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1266738007578 B12 binding site [chemical binding]; other site 1266738007579 cobalt ligand [ion binding]; other site 1266738007580 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1266738007581 transcriptional repressor IclR; Provisional; Region: PRK11569 1266738007582 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1266738007583 Bacterial transcriptional regulator; Region: IclR; pfam01614 1266738007584 phosphogluconate dehydratase; Validated; Region: PRK09054 1266738007585 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1266738007586 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1266738007587 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1266738007588 active site 1266738007589 intersubunit interface [polypeptide binding]; other site 1266738007590 catalytic residue [active] 1266738007591 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1266738007592 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1266738007593 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1266738007594 malate synthase A; Region: malate_syn_A; TIGR01344 1266738007595 active site 1266738007596 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1266738007597 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1266738007598 proposed active site lysine [active] 1266738007599 conserved cys residue [active] 1266738007600 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1266738007601 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1266738007602 dimer interface [polypeptide binding]; other site 1266738007603 active site 1266738007604 metal binding site [ion binding]; metal-binding site 1266738007605 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1266738007606 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1266738007607 active site 1266738007608 metal binding site [ion binding]; metal-binding site 1266738007609 nudix motif; other site 1266738007610 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1266738007611 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1266738007612 purine monophosphate binding site [chemical binding]; other site 1266738007613 dimer interface [polypeptide binding]; other site 1266738007614 putative catalytic residues [active] 1266738007615 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1266738007616 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1266738007617 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1266738007618 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1266738007619 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1266738007620 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1266738007621 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 1266738007622 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1266738007623 IHF dimer interface [polypeptide binding]; other site 1266738007624 IHF - DNA interface [nucleotide binding]; other site 1266738007625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1266738007626 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1266738007627 Active_site [active] 1266738007628 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1266738007629 substrate binding site [chemical binding]; other site 1266738007630 active site 1266738007631 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1266738007632 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1266738007633 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1266738007634 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1266738007635 putative NADH binding site [chemical binding]; other site 1266738007636 putative active site [active] 1266738007637 nudix motif; other site 1266738007638 putative metal binding site [ion binding]; other site 1266738007639 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1266738007640 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1266738007641 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1266738007642 ThiC-associated domain; Region: ThiC-associated; pfam13667 1266738007643 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1266738007644 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1266738007645 thiamine phosphate binding site [chemical binding]; other site 1266738007646 active site 1266738007647 pyrophosphate binding site [ion binding]; other site 1266738007648 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1266738007649 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1266738007650 ATP binding site [chemical binding]; other site 1266738007651 substrate interface [chemical binding]; other site 1266738007652 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1266738007653 thiS-thiF/thiG interaction site; other site 1266738007654 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1266738007655 ThiS interaction site; other site 1266738007656 putative active site [active] 1266738007657 tetramer interface [polypeptide binding]; other site 1266738007658 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1266738007659 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1266738007660 FeS/SAM binding site; other site 1266738007661 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1266738007662 putative transposase; Provisional; Region: PRK09857 1266738007663 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1266738007664 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1266738007665 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1266738007666 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1266738007667 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1266738007668 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1266738007669 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1266738007670 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1266738007671 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1266738007672 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1266738007673 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1266738007674 DNA binding site [nucleotide binding] 1266738007675 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1266738007676 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1266738007677 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1266738007678 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1266738007679 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1266738007680 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1266738007681 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1266738007682 RPB3 interaction site [polypeptide binding]; other site 1266738007683 RPB1 interaction site [polypeptide binding]; other site 1266738007684 RPB11 interaction site [polypeptide binding]; other site 1266738007685 RPB10 interaction site [polypeptide binding]; other site 1266738007686 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1266738007687 core dimer interface [polypeptide binding]; other site 1266738007688 peripheral dimer interface [polypeptide binding]; other site 1266738007689 L10 interface [polypeptide binding]; other site 1266738007690 L11 interface [polypeptide binding]; other site 1266738007691 putative EF-Tu interaction site [polypeptide binding]; other site 1266738007692 putative EF-G interaction site [polypeptide binding]; other site 1266738007693 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1266738007694 23S rRNA interface [nucleotide binding]; other site 1266738007695 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1266738007696 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1266738007697 mRNA/rRNA interface [nucleotide binding]; other site 1266738007698 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1266738007699 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1266738007700 23S rRNA interface [nucleotide binding]; other site 1266738007701 L7/L12 interface [polypeptide binding]; other site 1266738007702 putative thiostrepton binding site; other site 1266738007703 L25 interface [polypeptide binding]; other site 1266738007704 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1266738007705 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1266738007706 putative homodimer interface [polypeptide binding]; other site 1266738007707 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1266738007708 heterodimer interface [polypeptide binding]; other site 1266738007709 homodimer interface [polypeptide binding]; other site 1266738007710 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1266738007711 elongation factor Tu; Reviewed; Region: PRK00049 1266738007712 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1266738007713 G1 box; other site 1266738007714 GEF interaction site [polypeptide binding]; other site 1266738007715 GTP/Mg2+ binding site [chemical binding]; other site 1266738007716 Switch I region; other site 1266738007717 G2 box; other site 1266738007718 G3 box; other site 1266738007719 Switch II region; other site 1266738007720 G4 box; other site 1266738007721 G5 box; other site 1266738007722 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1266738007723 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1266738007724 Antibiotic Binding Site [chemical binding]; other site 1266738007725 elongation factor G; Reviewed; Region: PRK00007 1266738007726 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1266738007727 G1 box; other site 1266738007728 putative GEF interaction site [polypeptide binding]; other site 1266738007729 GTP/Mg2+ binding site [chemical binding]; other site 1266738007730 Switch I region; other site 1266738007731 G2 box; other site 1266738007732 G3 box; other site 1266738007733 Switch II region; other site 1266738007734 G4 box; other site 1266738007735 G5 box; other site 1266738007736 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1266738007737 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1266738007738 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1266738007739 30S ribosomal protein S7; Validated; Region: PRK05302 1266738007740 DsrH like protein; Region: DsrH; cl17347 1266738007741 sulfur relay protein TusC; Validated; Region: PRK00211 1266738007742 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1266738007743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1266738007744 YheO-like PAS domain; Region: PAS_6; pfam08348 1266738007745 HTH domain; Region: HTH_22; pfam13309 1266738007746 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1266738007747 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1266738007748 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1266738007749 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1266738007750 SlyX; Region: SlyX; pfam04102 1266738007751 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1266738007752 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1266738007753 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 1266738007754 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1266738007755 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1266738007756 TrkA-N domain; Region: TrkA_N; pfam02254 1266738007757 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 1266738007758 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1266738007759 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1266738007760 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1266738007761 ABC transporter; Region: ABC_tran_2; pfam12848 1266738007762 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1266738007763 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1266738007764 dimerization interface [polypeptide binding]; other site 1266738007765 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1266738007766 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1266738007767 dimer interface [polypeptide binding]; other site 1266738007768 putative CheW interface [polypeptide binding]; other site 1266738007769 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1266738007770 HAMP domain; Region: HAMP; pfam00672 1266738007771 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1266738007772 dimer interface [polypeptide binding]; other site 1266738007773 putative CheW interface [polypeptide binding]; other site 1266738007774 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1266738007775 PAS domain; Region: PAS_9; pfam13426 1266738007776 putative active site [active] 1266738007777 heme pocket [chemical binding]; other site 1266738007778 HAMP domain; Region: HAMP; pfam00672 1266738007779 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1266738007780 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1266738007781 dimer interface [polypeptide binding]; other site 1266738007782 putative CheW interface [polypeptide binding]; other site 1266738007783 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1266738007784 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1266738007785 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1266738007786 putative active site [active] 1266738007787 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1266738007788 putative hydrolase; Provisional; Region: PRK10985 1266738007789 hypothetical protein; Provisional; Region: PRK04966 1266738007790 phosphoribulokinase; Provisional; Region: PRK15453 1266738007791 active site 1266738007792 hypothetical protein; Provisional; Region: PRK10738 1266738007793 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1266738007794 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1266738007795 ligand binding site [chemical binding]; other site 1266738007796 flexible hinge region; other site 1266738007797 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1266738007798 putative switch regulator; other site 1266738007799 non-specific DNA interactions [nucleotide binding]; other site 1266738007800 DNA binding site [nucleotide binding] 1266738007801 sequence specific DNA binding site [nucleotide binding]; other site 1266738007802 putative cAMP binding site [chemical binding]; other site 1266738007803 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1266738007804 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1266738007805 inhibitor-cofactor binding pocket; inhibition site 1266738007806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738007807 catalytic residue [active] 1266738007808 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1266738007809 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1266738007810 glutamine binding [chemical binding]; other site 1266738007811 catalytic triad [active] 1266738007812 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1266738007813 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1266738007814 active site 1266738007815 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1266738007816 G1 box; other site 1266738007817 GTP/Mg2+ binding site [chemical binding]; other site 1266738007818 Switch I region; other site 1266738007819 G2 box; other site 1266738007820 G3 box; other site 1266738007821 Switch II region; other site 1266738007822 G4 box; other site 1266738007823 G5 box; other site 1266738007824 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1266738007825 active site 1266738007826 catalytic residues [active] 1266738007827 metal binding site [ion binding]; metal-binding site 1266738007828 DNA polymerase I; Provisional; Region: PRK05755 1266738007829 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1266738007830 active site 1266738007831 metal binding site 1 [ion binding]; metal-binding site 1266738007832 putative 5' ssDNA interaction site; other site 1266738007833 metal binding site 3; metal-binding site 1266738007834 metal binding site 2 [ion binding]; metal-binding site 1266738007835 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1266738007836 putative DNA binding site [nucleotide binding]; other site 1266738007837 putative metal binding site [ion binding]; other site 1266738007838 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1266738007839 active site 1266738007840 catalytic site [active] 1266738007841 substrate binding site [chemical binding]; other site 1266738007842 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1266738007843 active site 1266738007844 DNA binding site [nucleotide binding] 1266738007845 catalytic site [active] 1266738007846 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 1266738007847 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1266738007848 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1266738007849 catalytic residues [active] 1266738007850 hinge region; other site 1266738007851 alpha helical domain; other site 1266738007852 serine/threonine protein kinase; Provisional; Region: PRK11768 1266738007853 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1266738007854 Protein of unknown function (DUF1040); Region: DUF1040; cl01176 1266738007855 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1266738007856 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1266738007857 GTP binding site; other site 1266738007858 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1266738007859 Walker A motif; other site 1266738007860 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1266738007861 active site 1266738007862 catalytic site [active] 1266738007863 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1266738007864 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1266738007865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1266738007866 Probable transposase; Region: OrfB_IS605; pfam01385 1266738007867 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1266738007868 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1266738007869 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1266738007870 active site 1266738007871 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 1266738007872 homotrimer interaction site [polypeptide binding]; other site 1266738007873 putative active site [active] 1266738007874 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1266738007875 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1266738007876 glutathione reductase; Validated; Region: PRK06116 1266738007877 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1266738007878 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1266738007879 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1266738007880 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1266738007881 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1266738007882 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1266738007883 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1266738007884 active site 1 [active] 1266738007885 dimer interface [polypeptide binding]; other site 1266738007886 hexamer interface [polypeptide binding]; other site 1266738007887 active site 2 [active] 1266738007888 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1266738007889 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1266738007890 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1266738007891 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1266738007892 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1266738007893 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1266738007894 Walker A/P-loop; other site 1266738007895 ATP binding site [chemical binding]; other site 1266738007896 Q-loop/lid; other site 1266738007897 ABC transporter signature motif; other site 1266738007898 Walker B; other site 1266738007899 D-loop; other site 1266738007900 H-loop/switch region; other site 1266738007901 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1266738007902 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1266738007903 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1266738007904 Walker A/P-loop; other site 1266738007905 ATP binding site [chemical binding]; other site 1266738007906 Q-loop/lid; other site 1266738007907 ABC transporter signature motif; other site 1266738007908 Walker B; other site 1266738007909 D-loop; other site 1266738007910 H-loop/switch region; other site 1266738007911 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1266738007912 dipeptide transporter; Provisional; Region: PRK10913 1266738007913 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1266738007914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738007915 dimer interface [polypeptide binding]; other site 1266738007916 conserved gate region; other site 1266738007917 putative PBP binding loops; other site 1266738007918 ABC-ATPase subunit interface; other site 1266738007919 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1266738007920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738007921 dimer interface [polypeptide binding]; other site 1266738007922 conserved gate region; other site 1266738007923 putative PBP binding loops; other site 1266738007924 ABC-ATPase subunit interface; other site 1266738007925 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1266738007926 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1266738007927 peptide binding site [polypeptide binding]; other site 1266738007928 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1266738007929 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1266738007930 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1266738007931 putative transporter; Validated; Region: PRK03818 1266738007932 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1266738007933 TrkA-C domain; Region: TrkA_C; pfam02080 1266738007934 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1266738007935 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1266738007936 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1266738007937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738007938 homodimer interface [polypeptide binding]; other site 1266738007939 catalytic residue [active] 1266738007940 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1266738007941 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1266738007942 dimer interface [polypeptide binding]; other site 1266738007943 motif 1; other site 1266738007944 active site 1266738007945 motif 2; other site 1266738007946 motif 3; other site 1266738007947 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1266738007948 DALR anticodon binding domain; Region: DALR_1; pfam05746 1266738007949 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 1266738007950 Predicted transcriptional regulator [Transcription]; Region: COG2944 1266738007951 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738007952 non-specific DNA binding site [nucleotide binding]; other site 1266738007953 salt bridge; other site 1266738007954 sequence-specific DNA binding site [nucleotide binding]; other site 1266738007955 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1266738007956 putative catalytic site [active] 1266738007957 putative metal binding site [ion binding]; other site 1266738007958 putative phosphate binding site [ion binding]; other site 1266738007959 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 1266738007960 Predicted membrane protein [Function unknown]; Region: COG2860 1266738007961 UPF0126 domain; Region: UPF0126; pfam03458 1266738007962 UPF0126 domain; Region: UPF0126; pfam03458 1266738007963 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1266738007964 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1266738007965 catalytic site [active] 1266738007966 G-X2-G-X-G-K; other site 1266738007967 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1266738007968 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1266738007969 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1266738007970 Zn2+ binding site [ion binding]; other site 1266738007971 Mg2+ binding site [ion binding]; other site 1266738007972 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1266738007973 synthetase active site [active] 1266738007974 NTP binding site [chemical binding]; other site 1266738007975 metal binding site [ion binding]; metal-binding site 1266738007976 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1266738007977 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1266738007978 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1266738007979 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1266738007980 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1266738007981 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1266738007982 Y-family of DNA polymerases; Region: PolY; cl12025 1266738007983 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1266738007984 generic binding surface II; other site 1266738007985 ssDNA binding site; other site 1266738007986 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1266738007987 ATP binding site [chemical binding]; other site 1266738007988 putative Mg++ binding site [ion binding]; other site 1266738007989 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1266738007990 nucleotide binding region [chemical binding]; other site 1266738007991 ATP-binding site [chemical binding]; other site 1266738007992 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1266738007993 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1266738007994 AsmA family; Region: AsmA; pfam05170 1266738007995 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 1266738007996 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1266738007997 RNA binding surface [nucleotide binding]; other site 1266738007998 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1266738007999 probable active site [active] 1266738008000 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1266738008001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1266738008002 Coenzyme A binding pocket [chemical binding]; other site 1266738008003 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1266738008004 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1266738008005 putative active site [active] 1266738008006 dimerization interface [polypeptide binding]; other site 1266738008007 putative tRNAtyr binding site [nucleotide binding]; other site 1266738008008 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1266738008009 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1266738008010 motif II; other site 1266738008011 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1266738008012 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1266738008013 G1 box; other site 1266738008014 putative GEF interaction site [polypeptide binding]; other site 1266738008015 GTP/Mg2+ binding site [chemical binding]; other site 1266738008016 Switch I region; other site 1266738008017 G2 box; other site 1266738008018 G3 box; other site 1266738008019 Switch II region; other site 1266738008020 G4 box; other site 1266738008021 G5 box; other site 1266738008022 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1266738008023 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1266738008024 glutamine synthetase; Provisional; Region: glnA; PRK09469 1266738008025 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1266738008026 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1266738008027 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1266738008028 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1266738008029 putative active site [active] 1266738008030 heme pocket [chemical binding]; other site 1266738008031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1266738008032 ATP binding site [chemical binding]; other site 1266738008033 Mg2+ binding site [ion binding]; other site 1266738008034 G-X-G motif; other site 1266738008035 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1266738008036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738008037 active site 1266738008038 phosphorylation site [posttranslational modification] 1266738008039 intermolecular recognition site; other site 1266738008040 dimerization interface [polypeptide binding]; other site 1266738008041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1266738008042 Walker A motif; other site 1266738008043 ATP binding site [chemical binding]; other site 1266738008044 Walker B motif; other site 1266738008045 arginine finger; other site 1266738008046 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1266738008047 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1266738008048 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1266738008049 FeS/SAM binding site; other site 1266738008050 HemN C-terminal domain; Region: HemN_C; pfam06969 1266738008051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 1266738008052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 1266738008053 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 1266738008054 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1266738008055 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1266738008056 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1266738008057 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1266738008058 RNA binding site [nucleotide binding]; other site 1266738008059 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1266738008060 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1266738008061 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1266738008062 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1266738008063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738008064 active site 1266738008065 phosphorylation site [posttranslational modification] 1266738008066 intermolecular recognition site; other site 1266738008067 dimerization interface [polypeptide binding]; other site 1266738008068 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1266738008069 DNA binding site [nucleotide binding] 1266738008070 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1266738008071 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1266738008072 dimerization interface [polypeptide binding]; other site 1266738008073 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1266738008074 dimer interface [polypeptide binding]; other site 1266738008075 phosphorylation site [posttranslational modification] 1266738008076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1266738008077 ATP binding site [chemical binding]; other site 1266738008078 Mg2+ binding site [ion binding]; other site 1266738008079 G-X-G motif; other site 1266738008080 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1266738008081 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1266738008082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738008083 dimer interface [polypeptide binding]; other site 1266738008084 conserved gate region; other site 1266738008085 putative PBP binding loops; other site 1266738008086 ABC-ATPase subunit interface; other site 1266738008087 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1266738008088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738008089 dimer interface [polypeptide binding]; other site 1266738008090 conserved gate region; other site 1266738008091 putative PBP binding loops; other site 1266738008092 ABC-ATPase subunit interface; other site 1266738008093 transcriptional regulator PhoU; Provisional; Region: PRK11115 1266738008094 PhoU domain; Region: PhoU; pfam01895 1266738008095 PhoU domain; Region: PhoU; pfam01895 1266738008096 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1266738008097 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1266738008098 substrate binding pocket [chemical binding]; other site 1266738008099 membrane-bound complex binding site; other site 1266738008100 hinge residues; other site 1266738008101 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1266738008102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738008103 dimer interface [polypeptide binding]; other site 1266738008104 conserved gate region; other site 1266738008105 putative PBP binding loops; other site 1266738008106 ABC-ATPase subunit interface; other site 1266738008107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738008108 dimer interface [polypeptide binding]; other site 1266738008109 conserved gate region; other site 1266738008110 putative PBP binding loops; other site 1266738008111 ABC-ATPase subunit interface; other site 1266738008112 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1266738008113 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1266738008114 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1266738008115 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738008116 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1266738008117 Walker A/P-loop; other site 1266738008118 ATP binding site [chemical binding]; other site 1266738008119 Q-loop/lid; other site 1266738008120 ABC transporter signature motif; other site 1266738008121 Walker B; other site 1266738008122 D-loop; other site 1266738008123 H-loop/switch region; other site 1266738008124 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1266738008125 Beta-ketoacyl synthase, C-terminal domain; Region: Ketoacyl-synt_C; pfam02801 1266738008126 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1266738008127 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1266738008128 dimer interface [polypeptide binding]; other site 1266738008129 active site 1266738008130 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1266738008131 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1266738008132 active site 1266738008133 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1266738008134 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1266738008135 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1266738008136 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 1266738008137 active site 2 [active] 1266738008138 active site 1 [active] 1266738008139 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1266738008140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1266738008141 NAD(P) binding site [chemical binding]; other site 1266738008142 active site 1266738008143 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1266738008144 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1266738008145 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1266738008146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1266738008147 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1266738008148 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1266738008149 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 1266738008150 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 1266738008151 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1266738008152 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1266738008153 G1 box; other site 1266738008154 GTP/Mg2+ binding site [chemical binding]; other site 1266738008155 Switch I region; other site 1266738008156 G2 box; other site 1266738008157 G3 box; other site 1266738008158 Switch II region; other site 1266738008159 G4 box; other site 1266738008160 G5 box; other site 1266738008161 Nucleoside recognition; Region: Gate; pfam07670 1266738008162 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1266738008163 Nucleoside recognition; Region: Gate; pfam07670 1266738008164 OsmC-like protein; Region: OsmC; pfam02566 1266738008165 carboxylesterase BioH; Provisional; Region: PRK10349 1266738008166 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1266738008167 DNA utilization protein GntX; Provisional; Region: PRK11595 1266738008168 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1266738008169 active site 1266738008170 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1266738008171 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1266738008172 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1266738008173 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1266738008174 active site residue [active] 1266738008175 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1266738008176 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1266738008177 Rhomboid family; Region: Rhomboid; pfam01694 1266738008178 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1266738008179 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1266738008180 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1266738008181 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1266738008182 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1266738008183 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1266738008184 FAD binding site [chemical binding]; other site 1266738008185 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 1266738008186 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1266738008187 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1266738008188 DNA binding site [nucleotide binding] 1266738008189 domain linker motif; other site 1266738008190 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1266738008191 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1266738008192 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1266738008193 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 1266738008194 BNR repeat-like domain; Region: BNR_2; pfam13088 1266738008195 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1266738008196 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1266738008197 inhibitor site; inhibition site 1266738008198 active site 1266738008199 dimer interface [polypeptide binding]; other site 1266738008200 catalytic residue [active] 1266738008201 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1266738008202 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1266738008203 substrate binding site [chemical binding]; other site 1266738008204 trimer interface [polypeptide binding]; other site 1266738008205 Mn binding site [ion binding]; other site 1266738008206 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1266738008207 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1266738008208 Walker A/P-loop; other site 1266738008209 ATP binding site [chemical binding]; other site 1266738008210 Q-loop/lid; other site 1266738008211 ABC transporter signature motif; other site 1266738008212 Walker B; other site 1266738008213 D-loop; other site 1266738008214 H-loop/switch region; other site 1266738008215 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1266738008216 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1266738008217 Walker A/P-loop; other site 1266738008218 ATP binding site [chemical binding]; other site 1266738008219 Q-loop/lid; other site 1266738008220 ABC transporter signature motif; other site 1266738008221 Walker B; other site 1266738008222 D-loop; other site 1266738008223 H-loop/switch region; other site 1266738008224 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1266738008225 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1266738008226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738008227 dimer interface [polypeptide binding]; other site 1266738008228 conserved gate region; other site 1266738008229 putative PBP binding loops; other site 1266738008230 ABC-ATPase subunit interface; other site 1266738008231 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 1266738008232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738008233 dimer interface [polypeptide binding]; other site 1266738008234 conserved gate region; other site 1266738008235 putative PBP binding loops; other site 1266738008236 ABC-ATPase subunit interface; other site 1266738008237 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1266738008238 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1266738008239 substrate binding site [chemical binding]; other site 1266738008240 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1266738008241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738008242 S-adenosylmethionine binding site [chemical binding]; other site 1266738008243 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1266738008244 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1266738008245 putative active site [active] 1266738008246 YdjC motif; other site 1266738008247 Mg binding site [ion binding]; other site 1266738008248 putative homodimer interface [polypeptide binding]; other site 1266738008249 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1266738008250 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1266738008251 NAD binding site [chemical binding]; other site 1266738008252 sugar binding site [chemical binding]; other site 1266738008253 divalent metal binding site [ion binding]; other site 1266738008254 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1266738008255 dimer interface [polypeptide binding]; other site 1266738008256 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 1266738008257 Cupin domain; Region: Cupin_2; pfam07883 1266738008258 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1266738008259 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1266738008260 active site 1266738008261 methionine cluster; other site 1266738008262 phosphorylation site [posttranslational modification] 1266738008263 metal binding site [ion binding]; metal-binding site 1266738008264 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 1266738008265 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1266738008266 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1266738008267 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1266738008268 putative ligand binding residues [chemical binding]; other site 1266738008269 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1266738008270 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1266738008271 ABC-ATPase subunit interface; other site 1266738008272 dimer interface [polypeptide binding]; other site 1266738008273 putative PBP binding regions; other site 1266738008274 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1266738008275 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1266738008276 Walker A/P-loop; other site 1266738008277 ATP binding site [chemical binding]; other site 1266738008278 Q-loop/lid; other site 1266738008279 ABC transporter signature motif; other site 1266738008280 Walker B; other site 1266738008281 D-loop; other site 1266738008282 H-loop/switch region; other site 1266738008283 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1266738008284 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1266738008285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738008286 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1266738008287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738008288 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1266738008289 Spore germination protein; Region: Spore_permease; cl17796 1266738008290 arginine decarboxylase; Provisional; Region: PRK15029 1266738008291 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1266738008292 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1266738008293 homodimer interface [polypeptide binding]; other site 1266738008294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738008295 catalytic residue [active] 1266738008296 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1266738008297 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1266738008298 Spore germination protein; Region: Spore_permease; cl17796 1266738008299 Cupin domain; Region: Cupin_2; cl17218 1266738008300 Helix-turn-helix domain; Region: HTH_18; pfam12833 1266738008301 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1266738008302 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1266738008303 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1266738008304 putative [Fe4-S4] binding site [ion binding]; other site 1266738008305 putative molybdopterin cofactor binding site [chemical binding]; other site 1266738008306 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1266738008307 putative molybdopterin cofactor binding site; other site 1266738008308 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1266738008309 4Fe-4S binding domain; Region: Fer4; pfam00037 1266738008310 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 1266738008311 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1266738008312 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1266738008313 DNA binding site [nucleotide binding] 1266738008314 domain linker motif; other site 1266738008315 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1266738008316 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1266738008317 putative hydrolase; Provisional; Region: PRK02113 1266738008318 nucleoside transporter; Region: 2A0110; TIGR00889 1266738008319 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1266738008320 MgtC family; Region: MgtC; pfam02308 1266738008321 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1266738008322 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1266738008323 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1266738008324 Class I aldolases; Region: Aldolase_Class_I; cl17187 1266738008325 catalytic residue [active] 1266738008326 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1266738008327 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1266738008328 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1266738008329 putative active site [active] 1266738008330 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1266738008331 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 1266738008332 Na binding site [ion binding]; other site 1266738008333 N-acetylmannosamine kinase; Provisional; Region: PRK05082 1266738008334 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1266738008335 nucleotide binding site [chemical binding]; other site 1266738008336 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1266738008337 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1266738008338 putative active site cavity [active] 1266738008339 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1266738008340 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1266738008341 [4Fe-4S] binding site [ion binding]; other site 1266738008342 molybdopterin cofactor binding site; other site 1266738008343 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1266738008344 molybdopterin cofactor binding site; other site 1266738008345 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1266738008346 Na2 binding site [ion binding]; other site 1266738008347 putative substrate binding site 1 [chemical binding]; other site 1266738008348 Na binding site 1 [ion binding]; other site 1266738008349 putative substrate binding site 2 [chemical binding]; other site 1266738008350 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1266738008351 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1266738008352 tetramer interface [polypeptide binding]; other site 1266738008353 active site 1266738008354 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1266738008355 PTS system, maltose and glucose-specific IIBC component; Region: PTS-IIBC-malX; TIGR02004 1266738008356 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1266738008357 active site turn [active] 1266738008358 phosphorylation site [posttranslational modification] 1266738008359 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1266738008360 transcriptional regulator MurR; Provisional; Region: PRK15482 1266738008361 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1266738008362 putative active site [active] 1266738008363 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1266738008364 DNA-binding site [nucleotide binding]; DNA binding site 1266738008365 RNA-binding motif; other site 1266738008366 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1266738008367 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1266738008368 active site 1266738008369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 1266738008370 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1266738008371 active site 1266738008372 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1266738008373 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1266738008374 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1266738008375 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1266738008376 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1266738008377 PAAR motif; Region: PAAR_motif; pfam05488 1266738008378 PAAR motif; Region: PAAR_motif; pfam05488 1266738008379 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1266738008380 oligopeptidase A; Provisional; Region: PRK10911 1266738008381 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1266738008382 active site 1266738008383 Zn binding site [ion binding]; other site 1266738008384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738008385 S-adenosylmethionine binding site [chemical binding]; other site 1266738008386 short chain dehydrogenase; Provisional; Region: PRK06841 1266738008387 classical (c) SDRs; Region: SDR_c; cd05233 1266738008388 NAD(P) binding site [chemical binding]; other site 1266738008389 active site 1266738008390 glutamate dehydrogenase; Provisional; Region: PRK09414 1266738008391 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1266738008392 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1266738008393 NAD(P) binding site [chemical binding]; other site 1266738008394 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1266738008395 Ligand Binding Site [chemical binding]; other site 1266738008396 universal stress protein UspB; Provisional; Region: PRK04960 1266738008397 Predicted flavoproteins [General function prediction only]; Region: COG2081 1266738008398 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1266738008399 Pirin-related protein [General function prediction only]; Region: COG1741 1266738008400 Pirin; Region: Pirin; pfam02678 1266738008401 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1266738008402 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1266738008403 active site 1266738008404 substrate-binding site [chemical binding]; other site 1266738008405 metal-binding site [ion binding] 1266738008406 ATP binding site [chemical binding]; other site 1266738008407 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1266738008408 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1266738008409 dimerization interface [polypeptide binding]; other site 1266738008410 domain crossover interface; other site 1266738008411 redox-dependent activation switch; other site 1266738008412 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1266738008413 RNA binding surface [nucleotide binding]; other site 1266738008414 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1266738008415 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1266738008416 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1266738008417 ADP-ribose binding site [chemical binding]; other site 1266738008418 dimer interface [polypeptide binding]; other site 1266738008419 active site 1266738008420 nudix motif; other site 1266738008421 metal binding site [ion binding]; metal-binding site 1266738008422 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1266738008423 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1266738008424 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1266738008425 Transglycosylase; Region: Transgly; pfam00912 1266738008426 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1266738008427 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1266738008428 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1266738008429 shikimate kinase; Reviewed; Region: aroK; PRK00131 1266738008430 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1266738008431 ADP binding site [chemical binding]; other site 1266738008432 magnesium binding site [ion binding]; other site 1266738008433 putative shikimate binding site; other site 1266738008434 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1266738008435 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1266738008436 active site 1266738008437 dimer interface [polypeptide binding]; other site 1266738008438 metal binding site [ion binding]; metal-binding site 1266738008439 cell division protein DamX; Validated; Region: PRK10905 1266738008440 DNA adenine methylase; Provisional; Region: PRK10904 1266738008441 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1266738008442 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1266738008443 substrate binding site [chemical binding]; other site 1266738008444 hexamer interface [polypeptide binding]; other site 1266738008445 metal binding site [ion binding]; metal-binding site 1266738008446 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1266738008447 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1266738008448 motif II; other site 1266738008449 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1266738008450 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1266738008451 active site 1266738008452 HIGH motif; other site 1266738008453 dimer interface [polypeptide binding]; other site 1266738008454 KMSKS motif; other site 1266738008455 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 1266738008456 MOSC domain; Region: MOSC; pfam03473 1266738008457 3-alpha domain; Region: 3-alpha; pfam03475 1266738008458 superoxide dismutase; Provisional; Region: PRK10925 1266738008459 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1266738008460 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1266738008461 acetyl-CoA synthetase; Provisional; Region: PRK00174 1266738008462 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1266738008463 active site 1266738008464 CoA binding site [chemical binding]; other site 1266738008465 acyl-activating enzyme (AAE) consensus motif; other site 1266738008466 AMP binding site [chemical binding]; other site 1266738008467 acetate binding site [chemical binding]; other site 1266738008468 Predicted membrane protein [Function unknown]; Region: COG3162 1266738008469 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1266738008470 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1266738008471 Na binding site [ion binding]; other site 1266738008472 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1266738008473 Sulfatase; Region: Sulfatase; pfam00884 1266738008474 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1266738008475 iron-sulfur cluster-binding protein; Region: TIGR00273 1266738008476 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1266738008477 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1266738008478 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1266738008479 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1266738008480 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1266738008481 DNA-binding site [nucleotide binding]; DNA binding site 1266738008482 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1266738008483 putative transporter; Provisional; Region: PRK10504 1266738008484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738008485 putative substrate translocation pore; other site 1266738008486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738008487 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1266738008488 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1266738008489 substrate binding site [chemical binding]; other site 1266738008490 dimer interface [polypeptide binding]; other site 1266738008491 ATP binding site [chemical binding]; other site 1266738008492 regulatory ATPase RavA; Provisional; Region: PRK13531 1266738008493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1266738008494 Walker A motif; other site 1266738008495 ATP binding site [chemical binding]; other site 1266738008496 Walker B motif; other site 1266738008497 arginine finger; other site 1266738008498 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 1266738008499 hypothetical protein; Provisional; Region: yieM; PRK10997 1266738008500 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1266738008501 metal ion-dependent adhesion site (MIDAS); other site 1266738008502 asparagine synthetase AsnA; Provisional; Region: PRK05425 1266738008503 motif 1; other site 1266738008504 dimer interface [polypeptide binding]; other site 1266738008505 active site 1266738008506 motif 2; other site 1266738008507 motif 3; other site 1266738008508 FMN-binding protein MioC; Provisional; Region: PRK09004 1266738008509 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1266738008510 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1266738008511 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1266738008512 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1266738008513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738008514 S-adenosylmethionine binding site [chemical binding]; other site 1266738008515 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 1266738008516 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1266738008517 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1266738008518 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1266738008519 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1266738008520 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1266738008521 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1266738008522 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1266738008523 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1266738008524 beta subunit interaction interface [polypeptide binding]; other site 1266738008525 Walker A motif; other site 1266738008526 ATP binding site [chemical binding]; other site 1266738008527 Walker B motif; other site 1266738008528 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1266738008529 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1266738008530 core domain interface [polypeptide binding]; other site 1266738008531 delta subunit interface [polypeptide binding]; other site 1266738008532 epsilon subunit interface [polypeptide binding]; other site 1266738008533 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1266738008534 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1266738008535 gamma subunit interface [polypeptide binding]; other site 1266738008536 epsilon subunit interface [polypeptide binding]; other site 1266738008537 LBP interface [polypeptide binding]; other site 1266738008538 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1266738008539 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1266738008540 Substrate binding site; other site 1266738008541 Mg++ binding site; other site 1266738008542 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1266738008543 active site 1266738008544 substrate binding site [chemical binding]; other site 1266738008545 CoA binding site [chemical binding]; other site 1266738008546 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1266738008547 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1266738008548 glutaminase active site [active] 1266738008549 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1266738008550 dimer interface [polypeptide binding]; other site 1266738008551 active site 1266738008552 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1266738008553 dimer interface [polypeptide binding]; other site 1266738008554 active site 1266738008555 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 1266738008556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738008557 Walker A/P-loop; other site 1266738008558 ATP binding site [chemical binding]; other site 1266738008559 Q-loop/lid; other site 1266738008560 ABC transporter signature motif; other site 1266738008561 Walker B; other site 1266738008562 D-loop; other site 1266738008563 H-loop/switch region; other site 1266738008564 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 1266738008565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738008566 dimer interface [polypeptide binding]; other site 1266738008567 conserved gate region; other site 1266738008568 putative PBP binding loops; other site 1266738008569 ABC-ATPase subunit interface; other site 1266738008570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1266738008571 dimer interface [polypeptide binding]; other site 1266738008572 conserved gate region; other site 1266738008573 putative PBP binding loops; other site 1266738008574 ABC-ATPase subunit interface; other site 1266738008575 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1266738008576 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 1266738008577 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 1266738008578 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1266738008579 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1266738008580 motif II; other site 1266738008581 glutamate carboxypeptidase; Reviewed; Region: PRK06133 1266738008582 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1266738008583 metal binding site [ion binding]; metal-binding site 1266738008584 dimer interface [polypeptide binding]; other site 1266738008585 Predicted membrane protein [Function unknown]; Region: COG1288 1266738008586 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1266738008587 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1266738008588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1266738008589 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1266738008590 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1266738008591 HlyD family secretion protein; Region: HlyD_3; pfam13437 1266738008592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738008593 putative substrate translocation pore; other site 1266738008594 Protein of unknown function, DUF; Region: DUF411; cl01142 1266738008595 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1266738008596 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1266738008597 PapC C-terminal domain; Region: PapC_C; pfam13953 1266738008598 PapC N-terminal domain; Region: PapC_N; pfam13954 1266738008599 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1266738008600 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1266738008601 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1266738008602 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 1266738008603 Rhomboid family; Region: Rhomboid; cl11446 1266738008604 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1266738008605 fructokinase; Reviewed; Region: PRK09557 1266738008606 nucleotide binding site [chemical binding]; other site 1266738008607 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 1266738008608 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1266738008609 DXD motif; other site 1266738008610 PilZ domain; Region: PilZ; pfam07238 1266738008611 cellulose synthase regulator protein; Provisional; Region: PRK11114 1266738008612 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1266738008613 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1266738008614 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 1266738008615 PAS domain; Region: PAS_9; pfam13426 1266738008616 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1266738008617 putative active site [active] 1266738008618 heme pocket [chemical binding]; other site 1266738008619 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1266738008620 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1266738008621 metal binding site [ion binding]; metal-binding site 1266738008622 active site 1266738008623 I-site; other site 1266738008624 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1266738008625 active site 1266738008626 tetramer interface; other site 1266738008627 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1266738008628 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1266738008629 Sulfatase; Region: Sulfatase; cl17466 1266738008630 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1266738008631 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1266738008632 G1 box; other site 1266738008633 putative GEF interaction site [polypeptide binding]; other site 1266738008634 GTP/Mg2+ binding site [chemical binding]; other site 1266738008635 Switch I region; other site 1266738008636 G2 box; other site 1266738008637 G3 box; other site 1266738008638 Switch II region; other site 1266738008639 G4 box; other site 1266738008640 G5 box; other site 1266738008641 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1266738008642 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1266738008643 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1266738008644 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1266738008645 selenocysteine synthase; Provisional; Region: PRK04311 1266738008646 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1266738008647 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1266738008648 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1266738008649 catalytic residue [active] 1266738008650 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1266738008651 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1266738008652 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 1266738008653 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1266738008654 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1266738008655 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1266738008656 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1266738008657 molybdopterin cofactor binding site; other site 1266738008658 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1266738008659 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1266738008660 molybdopterin cofactor binding site; other site 1266738008661 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1266738008662 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1266738008663 Coenzyme A binding pocket [chemical binding]; other site 1266738008664 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 1266738008665 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1266738008666 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585 1266738008667 putative active site [active] 1266738008668 catalytic triad [active] 1266738008669 putative dimer interface [polypeptide binding]; other site 1266738008670 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1266738008671 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738008672 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1266738008673 dimerization interface [polypeptide binding]; other site 1266738008674 substrate binding pocket [chemical binding]; other site 1266738008675 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 1266738008676 Protein of unknown function (DUF560); Region: DUF560; pfam04575 1266738008677 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1266738008678 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 1266738008679 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1266738008680 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1266738008681 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 1266738008682 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1266738008683 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1266738008684 active site 1266738008685 metal binding site [ion binding]; metal-binding site 1266738008686 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1266738008687 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1266738008688 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738008689 non-specific DNA binding site [nucleotide binding]; other site 1266738008690 salt bridge; other site 1266738008691 sequence-specific DNA binding site [nucleotide binding]; other site 1266738008692 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1266738008693 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1266738008694 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1266738008695 G1 box; other site 1266738008696 GTP/Mg2+ binding site [chemical binding]; other site 1266738008697 Switch I region; other site 1266738008698 G2 box; other site 1266738008699 Switch II region; other site 1266738008700 G3 box; other site 1266738008701 G4 box; other site 1266738008702 G5 box; other site 1266738008703 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1266738008704 ribonuclease P; Reviewed; Region: rnpA; PRK01732 1266738008705 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1266738008706 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1266738008707 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1266738008708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1266738008709 Walker A motif; other site 1266738008710 ATP binding site [chemical binding]; other site 1266738008711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1266738008712 Walker B motif; other site 1266738008713 arginine finger; other site 1266738008714 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1266738008715 DnaA box-binding interface [nucleotide binding]; other site 1266738008716 DNA polymerase III subunit beta; Validated; Region: PRK05643 1266738008717 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1266738008718 putative DNA binding surface [nucleotide binding]; other site 1266738008719 dimer interface [polypeptide binding]; other site 1266738008720 beta-clamp/clamp loader binding surface; other site 1266738008721 beta-clamp/translesion DNA polymerase binding surface; other site 1266738008722 recF protein; Region: recf; TIGR00611 1266738008723 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738008724 Walker A/P-loop; other site 1266738008725 ATP binding site [chemical binding]; other site 1266738008726 Q-loop/lid; other site 1266738008727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1266738008728 ABC transporter signature motif; other site 1266738008729 Walker B; other site 1266738008730 D-loop; other site 1266738008731 H-loop/switch region; other site 1266738008732 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1266738008733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1266738008734 ATP binding site [chemical binding]; other site 1266738008735 Mg2+ binding site [ion binding]; other site 1266738008736 G-X-G motif; other site 1266738008737 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1266738008738 anchoring element; other site 1266738008739 dimer interface [polypeptide binding]; other site 1266738008740 ATP binding site [chemical binding]; other site 1266738008741 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1266738008742 active site 1266738008743 putative metal-binding site [ion binding]; other site 1266738008744 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1266738008745 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1266738008746 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1266738008747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738008748 S-adenosylmethionine binding site [chemical binding]; other site 1266738008749 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1266738008750 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1266738008751 DNA-binding site [nucleotide binding]; DNA binding site 1266738008752 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1266738008753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738008754 homodimer interface [polypeptide binding]; other site 1266738008755 catalytic residue [active] 1266738008756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1266738008757 Coenzyme A binding pocket [chemical binding]; other site 1266738008758 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1266738008759 Sel1-like repeats; Region: SEL1; smart00671 1266738008760 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1266738008761 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1266738008762 putative active site [active] 1266738008763 HipA N-terminal domain; Region: Couple_hipA; cl11853 1266738008764 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1266738008765 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1266738008766 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 1266738008767 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1266738008768 hypothetical protein; Provisional; Region: PRK11820 1266738008769 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1266738008770 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1266738008771 ribonuclease PH; Reviewed; Region: rph; PRK00173 1266738008772 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1266738008773 hexamer interface [polypeptide binding]; other site 1266738008774 active site 1266738008775 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1266738008776 active site 1266738008777 division inhibitor protein; Provisional; Region: slmA; PRK09480 1266738008778 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1266738008779 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1266738008780 trimer interface [polypeptide binding]; other site 1266738008781 active site 1266738008782 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1266738008783 Flavoprotein; Region: Flavoprotein; pfam02441 1266738008784 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1266738008785 hypothetical protein; Reviewed; Region: PRK00024 1266738008786 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1266738008787 MPN+ (JAMM) motif; other site 1266738008788 Zinc-binding site [ion binding]; other site 1266738008789 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1266738008790 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1266738008791 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1266738008792 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1266738008793 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1266738008794 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1266738008795 putative active site [active] 1266738008796 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1266738008797 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1266738008798 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1266738008799 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1266738008800 O-Antigen ligase; Region: Wzy_C; cl04850 1266738008801 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1266738008802 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1266738008803 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1266738008804 DNA binding site [nucleotide binding] 1266738008805 catalytic residue [active] 1266738008806 H2TH interface [polypeptide binding]; other site 1266738008807 putative catalytic residues [active] 1266738008808 turnover-facilitating residue; other site 1266738008809 intercalation triad [nucleotide binding]; other site 1266738008810 8OG recognition residue [nucleotide binding]; other site 1266738008811 putative reading head residues; other site 1266738008812 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1266738008813 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1266738008814 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1266738008815 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1266738008816 active site 1266738008817 (T/H)XGH motif; other site 1266738008818 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1266738008819 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1266738008820 putative metal binding site; other site 1266738008821 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1266738008822 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1266738008823 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1266738008824 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 1266738008825 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1266738008826 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1266738008827 putative active site [active] 1266738008828 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1266738008829 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1266738008830 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1266738008831 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1266738008832 putative ADP-binding pocket [chemical binding]; other site 1266738008833 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 1266738008834 putative active site [active] 1266738008835 putative catalytic site [active] 1266738008836 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1266738008837 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1266738008838 putative active site [active] 1266738008839 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 1266738008840 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1266738008841 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1266738008842 putative active site [active] 1266738008843 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1266738008844 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1266738008845 putative active site [active] 1266738008846 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1266738008847 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1266738008848 NADP binding site [chemical binding]; other site 1266738008849 homopentamer interface [polypeptide binding]; other site 1266738008850 substrate binding site [chemical binding]; other site 1266738008851 active site 1266738008852 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1266738008853 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1266738008854 substrate-cofactor binding pocket; other site 1266738008855 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738008856 catalytic residue [active] 1266738008857 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1266738008858 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1266738008859 NAD(P) binding site [chemical binding]; other site 1266738008860 Abi-like protein; Region: Abi_2; pfam07751 1266738008861 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1266738008862 NodB motif; other site 1266738008863 putative active site [active] 1266738008864 putative catalytic site [active] 1266738008865 Zn binding site [ion binding]; other site 1266738008866 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1266738008867 Peptidase family M23; Region: Peptidase_M23; pfam01551 1266738008868 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1266738008869 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1266738008870 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1266738008871 FeS/SAM binding site; other site 1266738008872 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1266738008873 active site residue [active] 1266738008874 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1266738008875 SecA binding site; other site 1266738008876 Preprotein binding site; other site 1266738008877 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1266738008878 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1266738008879 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1266738008880 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1266738008881 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1266738008882 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1266738008883 trimer interface [polypeptide binding]; other site 1266738008884 active site 1266738008885 substrate binding site [chemical binding]; other site 1266738008886 CoA binding site [chemical binding]; other site 1266738008887 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1266738008888 putative trimer interface [polypeptide binding]; other site 1266738008889 putative CoA binding site [chemical binding]; other site 1266738008890 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1266738008891 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1266738008892 active site 1266738008893 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1266738008894 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1266738008895 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1266738008896 LDH/MDH dimer interface [polypeptide binding]; other site 1266738008897 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1266738008898 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1266738008899 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1266738008900 trimer interface [polypeptide binding]; other site 1266738008901 active site 1266738008902 substrate binding site [chemical binding]; other site 1266738008903 CoA binding site [chemical binding]; other site 1266738008904 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1266738008905 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1266738008906 active site 1266738008907 dimer interface [polypeptide binding]; other site 1266738008908 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1266738008909 Ligand Binding Site [chemical binding]; other site 1266738008910 Molecular Tunnel; other site 1266738008911 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1266738008912 active site 1266738008913 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1266738008914 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1266738008915 putative ADP-binding pocket [chemical binding]; other site 1266738008916 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1266738008917 extended (e) SDRs; Region: SDR_e; cd08946 1266738008918 NAD(P) binding site [chemical binding]; other site 1266738008919 active site 1266738008920 substrate binding site [chemical binding]; other site 1266738008921 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1266738008922 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 1266738008923 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 1266738008924 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1266738008925 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1266738008926 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1266738008927 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1266738008928 substrate binding site; other site 1266738008929 tetramer interface; other site 1266738008930 Protein of unknown function (DUF707); Region: DUF707; pfam05212 1266738008931 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1266738008932 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1266738008933 UDP-galactopyranose mutase; Region: GLF; pfam03275 1266738008934 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1266738008935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738008936 active site 1266738008937 phosphorylation site [posttranslational modification] 1266738008938 intermolecular recognition site; other site 1266738008939 dimerization interface [polypeptide binding]; other site 1266738008940 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1266738008941 DNA binding site [nucleotide binding] 1266738008942 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1266738008943 dimer interface [polypeptide binding]; other site 1266738008944 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1266738008945 Sulfatase; Region: Sulfatase; cl17466 1266738008946 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1266738008947 classical (c) SDRs; Region: SDR_c; cd05233 1266738008948 NAD(P) binding site [chemical binding]; other site 1266738008949 active site 1266738008950 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1266738008951 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1266738008952 active site 1266738008953 ADP/pyrophosphate binding site [chemical binding]; other site 1266738008954 dimerization interface [polypeptide binding]; other site 1266738008955 allosteric effector site; other site 1266738008956 fructose-1,6-bisphosphate binding site; other site 1266738008957 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1266738008958 PBP superfamily domain; Region: PBP_like; cl17867 1266738008959 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1266738008960 membrane-bound complex binding site; other site 1266738008961 hinge residues; other site 1266738008962 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1266738008963 triosephosphate isomerase; Provisional; Region: PRK14567 1266738008964 substrate binding site [chemical binding]; other site 1266738008965 dimer interface [polypeptide binding]; other site 1266738008966 catalytic triad [active] 1266738008967 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1266738008968 Predicted membrane protein [Function unknown]; Region: COG3152 1266738008969 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1266738008970 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1266738008971 FAD binding pocket [chemical binding]; other site 1266738008972 FAD binding motif [chemical binding]; other site 1266738008973 phosphate binding motif [ion binding]; other site 1266738008974 beta-alpha-beta structure motif; other site 1266738008975 NAD binding pocket [chemical binding]; other site 1266738008976 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 1266738008977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738008978 putative substrate translocation pore; other site 1266738008979 glycerol kinase; Provisional; Region: glpK; PRK00047 1266738008980 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1266738008981 N- and C-terminal domain interface [polypeptide binding]; other site 1266738008982 active site 1266738008983 MgATP binding site [chemical binding]; other site 1266738008984 catalytic site [active] 1266738008985 metal binding site [ion binding]; metal-binding site 1266738008986 glycerol binding site [chemical binding]; other site 1266738008987 homotetramer interface [polypeptide binding]; other site 1266738008988 homodimer interface [polypeptide binding]; other site 1266738008989 FBP binding site [chemical binding]; other site 1266738008990 protein IIAGlc interface [polypeptide binding]; other site 1266738008991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 1266738008992 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1266738008993 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1266738008994 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1266738008995 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1266738008996 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1266738008997 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1266738008998 UbiA prenyltransferase family; Region: UbiA; pfam01040 1266738008999 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1266738009000 active site 1266738009001 HslU subunit interaction site [polypeptide binding]; other site 1266738009002 Sporulation related domain; Region: SPOR; cl10051 1266738009003 cell division protein FtsN; Provisional; Region: PRK12757 1266738009004 Sporulation related domain; Region: SPOR; cl10051 1266738009005 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1266738009006 DNA binding site [nucleotide binding] 1266738009007 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1266738009008 domain linker motif; other site 1266738009009 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1266738009010 dimerization interface [polypeptide binding]; other site 1266738009011 ligand binding site [chemical binding]; other site 1266738009012 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1266738009013 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1266738009014 ATP binding site [chemical binding]; other site 1266738009015 putative Mg++ binding site [ion binding]; other site 1266738009016 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1266738009017 ATP-binding site [chemical binding]; other site 1266738009018 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 1266738009019 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1266738009020 dimerization interface [polypeptide binding]; other site 1266738009021 putative DNA binding site [nucleotide binding]; other site 1266738009022 putative Zn2+ binding site [ion binding]; other site 1266738009023 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1266738009024 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1266738009025 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1266738009026 dimerization interface [polypeptide binding]; other site 1266738009027 DNA binding site [nucleotide binding] 1266738009028 corepressor binding sites; other site 1266738009029 cystathionine gamma-synthase; Provisional; Region: PRK08045 1266738009030 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1266738009031 homodimer interface [polypeptide binding]; other site 1266738009032 substrate-cofactor binding pocket; other site 1266738009033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738009034 catalytic residue [active] 1266738009035 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 1266738009036 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1266738009037 putative catalytic residues [active] 1266738009038 putative nucleotide binding site [chemical binding]; other site 1266738009039 putative aspartate binding site [chemical binding]; other site 1266738009040 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1266738009041 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1266738009042 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1266738009043 hypothetical protein; Provisional; Region: PRK05208 1266738009044 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1266738009045 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1266738009046 putative glycosyl transferase; Provisional; Region: PRK10073 1266738009047 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1266738009048 active site 1266738009049 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1266738009050 DNA photolyase; Region: DNA_photolyase; pfam00875 1266738009051 proline/glycine betaine transporter; Provisional; Region: PRK10642 1266738009052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738009053 putative substrate translocation pore; other site 1266738009054 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1266738009055 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1266738009056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738009057 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1266738009058 substrate binding site [chemical binding]; other site 1266738009059 dimerization interface [polypeptide binding]; other site 1266738009060 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1266738009061 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1266738009062 metal binding site [ion binding]; metal-binding site 1266738009063 dimer interface [polypeptide binding]; other site 1266738009064 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 1266738009065 pyruvate dehydrogenase; Provisional; Region: PRK09124 1266738009066 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1266738009067 PYR/PP interface [polypeptide binding]; other site 1266738009068 dimer interface [polypeptide binding]; other site 1266738009069 tetramer interface [polypeptide binding]; other site 1266738009070 TPP binding site [chemical binding]; other site 1266738009071 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1266738009072 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1266738009073 TPP-binding site [chemical binding]; other site 1266738009074 acetylornithine deacetylase; Provisional; Region: PRK05111 1266738009075 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1266738009076 metal binding site [ion binding]; metal-binding site 1266738009077 putative dimer interface [polypeptide binding]; other site 1266738009078 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1266738009079 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1266738009080 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1266738009081 nucleotide binding site [chemical binding]; other site 1266738009082 N-acetyl-L-glutamate binding site [chemical binding]; other site 1266738009083 argininosuccinate synthase; Provisional; Region: PRK13820 1266738009084 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1266738009085 ANP binding site [chemical binding]; other site 1266738009086 Substrate Binding Site II [chemical binding]; other site 1266738009087 Substrate Binding Site I [chemical binding]; other site 1266738009088 argininosuccinate lyase; Provisional; Region: PRK04833 1266738009089 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1266738009090 active sites [active] 1266738009091 tetramer interface [polypeptide binding]; other site 1266738009092 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1266738009093 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738009094 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1266738009095 dimerization interface [polypeptide binding]; other site 1266738009096 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1266738009097 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1266738009098 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1266738009099 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1266738009100 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1266738009101 hypothetical protein; Provisional; Region: PRK11056 1266738009102 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1266738009103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738009104 S-adenosylmethionine binding site [chemical binding]; other site 1266738009105 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 1266738009106 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1266738009107 N-terminal plug; other site 1266738009108 ligand-binding site [chemical binding]; other site 1266738009109 glutamate racemase; Provisional; Region: PRK00865 1266738009110 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1266738009111 FAD binding domain; Region: FAD_binding_4; pfam01565 1266738009112 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1266738009113 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1266738009114 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1266738009115 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1266738009116 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1266738009117 pantothenate kinase; Provisional; Region: PRK05439 1266738009118 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1266738009119 ATP-binding site [chemical binding]; other site 1266738009120 CoA-binding site [chemical binding]; other site 1266738009121 Mg2+-binding site [ion binding]; other site 1266738009122 elongation factor Tu; Reviewed; Region: PRK00049 1266738009123 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1266738009124 G1 box; other site 1266738009125 GEF interaction site [polypeptide binding]; other site 1266738009126 GTP/Mg2+ binding site [chemical binding]; other site 1266738009127 Switch I region; other site 1266738009128 G2 box; other site 1266738009129 G3 box; other site 1266738009130 Switch II region; other site 1266738009131 G4 box; other site 1266738009132 G5 box; other site 1266738009133 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1266738009134 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1266738009135 Antibiotic Binding Site [chemical binding]; other site 1266738009136 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1266738009137 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1266738009138 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1266738009139 heme binding site [chemical binding]; other site 1266738009140 ferroxidase pore; other site 1266738009141 ferroxidase diiron center [ion binding]; other site 1266738009142 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1266738009143 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1266738009144 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1266738009145 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1266738009146 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1266738009147 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1266738009148 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1266738009149 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1266738009150 protein-rRNA interface [nucleotide binding]; other site 1266738009151 putative translocon binding site; other site 1266738009152 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1266738009153 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1266738009154 G-X-X-G motif; other site 1266738009155 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1266738009156 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1266738009157 23S rRNA interface [nucleotide binding]; other site 1266738009158 5S rRNA interface [nucleotide binding]; other site 1266738009159 putative antibiotic binding site [chemical binding]; other site 1266738009160 L25 interface [polypeptide binding]; other site 1266738009161 L27 interface [polypeptide binding]; other site 1266738009162 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1266738009163 23S rRNA interface [nucleotide binding]; other site 1266738009164 putative translocon interaction site; other site 1266738009165 signal recognition particle (SRP54) interaction site; other site 1266738009166 L23 interface [polypeptide binding]; other site 1266738009167 trigger factor interaction site; other site 1266738009168 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1266738009169 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1266738009170 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1266738009171 RNA binding site [nucleotide binding]; other site 1266738009172 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1266738009173 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1266738009174 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1266738009175 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1266738009176 5S rRNA interface [nucleotide binding]; other site 1266738009177 23S rRNA interface [nucleotide binding]; other site 1266738009178 L5 interface [polypeptide binding]; other site 1266738009179 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1266738009180 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1266738009181 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1266738009182 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1266738009183 23S rRNA binding site [nucleotide binding]; other site 1266738009184 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1266738009185 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1266738009186 SecY translocase; Region: SecY; pfam00344 1266738009187 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1266738009188 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1266738009189 30S ribosomal protein S11; Validated; Region: PRK05309 1266738009190 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1266738009191 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1266738009192 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1266738009193 RNA binding surface [nucleotide binding]; other site 1266738009194 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1266738009195 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1266738009196 alphaNTD homodimer interface [polypeptide binding]; other site 1266738009197 alphaNTD - beta interaction site [polypeptide binding]; other site 1266738009198 alphaNTD - beta' interaction site [polypeptide binding]; other site 1266738009199 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1266738009200 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1266738009201 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1266738009202 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1266738009203 DNA binding residues [nucleotide binding] 1266738009204 dimer interface [polypeptide binding]; other site 1266738009205 metal binding site [ion binding]; metal-binding site 1266738009206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 1266738009207 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1266738009208 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1266738009209 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1266738009210 TrkA-N domain; Region: TrkA_N; pfam02254 1266738009211 TrkA-C domain; Region: TrkA_C; pfam02080 1266738009212 TrkA-N domain; Region: TrkA_N; pfam02254 1266738009213 TrkA-C domain; Region: TrkA_C; pfam02080 1266738009214 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1266738009215 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1266738009216 putative RNA binding site [nucleotide binding]; other site 1266738009217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738009218 S-adenosylmethionine binding site [chemical binding]; other site 1266738009219 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1266738009220 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1266738009221 putative active site [active] 1266738009222 substrate binding site [chemical binding]; other site 1266738009223 putative cosubstrate binding site; other site 1266738009224 catalytic site [active] 1266738009225 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1266738009226 substrate binding site [chemical binding]; other site 1266738009227 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1266738009228 active site 1266738009229 catalytic residues [active] 1266738009230 metal binding site [ion binding]; metal-binding site 1266738009231 hypothetical protein; Provisional; Region: PRK10736 1266738009232 DNA protecting protein DprA; Region: dprA; TIGR00732 1266738009233 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1266738009234 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1266738009235 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1266738009236 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1266738009237 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 1266738009238 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1266738009239 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1266738009240 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1266738009241 NAD(P) binding site [chemical binding]; other site 1266738009242 shikimate binding site; other site 1266738009243 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1266738009244 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1266738009245 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1266738009246 trimer interface [polypeptide binding]; other site 1266738009247 putative metal binding site [ion binding]; other site 1266738009248 transcriptional regulator HdfR; Provisional; Region: PRK03601 1266738009249 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738009250 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1266738009251 dimerization interface [polypeptide binding]; other site 1266738009252 hypothetical protein; Provisional; Region: PRK11027 1266738009253 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1266738009254 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1266738009255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1266738009256 Walker A motif; other site 1266738009257 ATP binding site [chemical binding]; other site 1266738009258 Walker B motif; other site 1266738009259 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1266738009260 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1266738009261 PYR/PP interface [polypeptide binding]; other site 1266738009262 dimer interface [polypeptide binding]; other site 1266738009263 TPP binding site [chemical binding]; other site 1266738009264 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1266738009265 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1266738009266 TPP-binding site [chemical binding]; other site 1266738009267 dimer interface [polypeptide binding]; other site 1266738009268 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1266738009269 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1266738009270 homodimer interface [polypeptide binding]; other site 1266738009271 substrate-cofactor binding pocket; other site 1266738009272 catalytic residue [active] 1266738009273 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1266738009274 threonine dehydratase; Reviewed; Region: PRK09224 1266738009275 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1266738009276 tetramer interface [polypeptide binding]; other site 1266738009277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738009278 catalytic residue [active] 1266738009279 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1266738009280 putative Ile/Val binding site [chemical binding]; other site 1266738009281 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1266738009282 putative Ile/Val binding site [chemical binding]; other site 1266738009283 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738009284 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1266738009285 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1266738009286 putative dimerization interface [polypeptide binding]; other site 1266738009287 ketol-acid reductoisomerase; Validated; Region: PRK05225 1266738009288 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1266738009289 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1266738009290 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1266738009291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 1266738009292 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 1266738009293 Part of AAA domain; Region: AAA_19; pfam13245 1266738009294 Family description; Region: UvrD_C_2; pfam13538 1266738009295 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1266738009296 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1266738009297 nucleotide binding site [chemical binding]; other site 1266738009298 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1266738009299 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1266738009300 ATP binding site [chemical binding]; other site 1266738009301 Mg++ binding site [ion binding]; other site 1266738009302 motif III; other site 1266738009303 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1266738009304 nucleotide binding region [chemical binding]; other site 1266738009305 ATP-binding site [chemical binding]; other site 1266738009306 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1266738009307 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1266738009308 catalytic residues [active] 1266738009309 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1266738009310 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1266738009311 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1266738009312 RNA binding site [nucleotide binding]; other site 1266738009313 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1266738009314 multimer interface [polypeptide binding]; other site 1266738009315 Walker A motif; other site 1266738009316 ATP binding site [chemical binding]; other site 1266738009317 Walker B motif; other site 1266738009318 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 1266738009319 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1266738009320 Mg++ binding site [ion binding]; other site 1266738009321 putative catalytic motif [active] 1266738009322 substrate binding site [chemical binding]; other site 1266738009323 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1266738009324 Chain length determinant protein; Region: Wzz; cl15801 1266738009325 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1266738009326 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1266738009327 active site 1266738009328 homodimer interface [polypeptide binding]; other site 1266738009329 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1266738009330 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1266738009331 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1266738009332 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1266738009333 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 1266738009334 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1266738009335 NAD binding site [chemical binding]; other site 1266738009336 substrate binding site [chemical binding]; other site 1266738009337 homodimer interface [polypeptide binding]; other site 1266738009338 active site 1266738009339 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1266738009340 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1266738009341 substrate binding site; other site 1266738009342 tetramer interface; other site 1266738009343 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1266738009344 Coenzyme A binding pocket [chemical binding]; other site 1266738009345 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1266738009346 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1266738009347 inhibitor-cofactor binding pocket; inhibition site 1266738009348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1266738009349 catalytic residue [active] 1266738009350 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1266738009351 putative common antigen polymerase; Provisional; Region: PRK02975 1266738009352 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1266738009353 HemY protein N-terminus; Region: HemY_N; pfam07219 1266738009354 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1266738009355 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 1266738009356 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1266738009357 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1266738009358 active site 1266738009359 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1266738009360 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1266738009361 domain interfaces; other site 1266738009362 active site 1266738009363 adenylate cyclase; Provisional; Region: cyaA; PRK09450 1266738009364 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1266738009365 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1266738009366 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1266738009367 putative iron binding site [ion binding]; other site 1266738009368 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 1266738009369 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1266738009370 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1266738009371 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1266738009372 hypothetical protein; Provisional; Region: PRK10963 1266738009373 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1266738009374 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1266738009375 active site 1266738009376 Int/Topo IB signature motif; other site 1266738009377 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1266738009378 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1266738009379 motif II; other site 1266738009380 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1266738009381 Part of AAA domain; Region: AAA_19; pfam13245 1266738009382 Family description; Region: UvrD_C_2; pfam13538 1266738009383 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1266738009384 EamA-like transporter family; Region: EamA; pfam00892 1266738009385 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1266738009386 CoenzymeA binding site [chemical binding]; other site 1266738009387 subunit interaction site [polypeptide binding]; other site 1266738009388 PHB binding site; other site 1266738009389 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1266738009390 dimerization interface [polypeptide binding]; other site 1266738009391 substrate binding site [chemical binding]; other site 1266738009392 active site 1266738009393 calcium binding site [ion binding]; other site 1266738009394 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1266738009395 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1266738009396 ATP binding site [chemical binding]; other site 1266738009397 putative Mg++ binding site [ion binding]; other site 1266738009398 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1266738009399 nucleotide binding region [chemical binding]; other site 1266738009400 ATP-binding site [chemical binding]; other site 1266738009401 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1266738009402 HRDC domain; Region: HRDC; pfam00570 1266738009403 lysophospholipase L2; Provisional; Region: PRK10749 1266738009404 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1266738009405 putative hydrolase; Provisional; Region: PRK10976 1266738009406 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1266738009407 active site 1266738009408 motif I; other site 1266738009409 motif II; other site 1266738009410 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1266738009411 Fimbrial protein; Region: Fimbrial; cl01416 1266738009412 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1266738009413 PapC N-terminal domain; Region: PapC_N; pfam13954 1266738009414 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1266738009415 PapC C-terminal domain; Region: PapC_C; pfam13953 1266738009416 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1266738009417 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1266738009418 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1266738009419 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1266738009420 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1266738009421 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738009422 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1266738009423 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1266738009424 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1266738009425 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1266738009426 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1266738009427 GTPase RsgA; Reviewed; Region: PRK12288 1266738009428 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1266738009429 RNA binding site [nucleotide binding]; other site 1266738009430 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1266738009431 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1266738009432 GTP/Mg2+ binding site [chemical binding]; other site 1266738009433 G4 box; other site 1266738009434 G5 box; other site 1266738009435 G1 box; other site 1266738009436 Switch I region; other site 1266738009437 G2 box; other site 1266738009438 G3 box; other site 1266738009439 Switch II region; other site 1266738009440 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1266738009441 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1266738009442 epoxyqueuosine reductase; Region: TIGR00276 1266738009443 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1266738009444 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1266738009445 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1266738009446 AMIN domain; Region: AMIN; pfam11741 1266738009447 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1266738009448 active site 1266738009449 metal binding site [ion binding]; metal-binding site 1266738009450 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1266738009451 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1266738009452 ATP binding site [chemical binding]; other site 1266738009453 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 1266738009454 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1266738009455 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1266738009456 bacterial Hfq-like; Region: Hfq; cd01716 1266738009457 hexamer interface [polypeptide binding]; other site 1266738009458 Sm1 motif; other site 1266738009459 RNA binding site [nucleotide binding]; other site 1266738009460 Sm2 motif; other site 1266738009461 GTPase HflX; Provisional; Region: PRK11058 1266738009462 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1266738009463 HflX GTPase family; Region: HflX; cd01878 1266738009464 G1 box; other site 1266738009465 GTP/Mg2+ binding site [chemical binding]; other site 1266738009466 Switch I region; other site 1266738009467 G2 box; other site 1266738009468 G3 box; other site 1266738009469 Switch II region; other site 1266738009470 G4 box; other site 1266738009471 G5 box; other site 1266738009472 FtsH protease regulator HflK; Provisional; Region: PRK10930 1266738009473 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1266738009474 FtsH protease regulator HflC; Provisional; Region: PRK11029 1266738009475 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1266738009476 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1266738009477 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1266738009478 GDP-binding site [chemical binding]; other site 1266738009479 ACT binding site; other site 1266738009480 IMP binding site; other site 1266738009481 Predicted transcriptional regulator [Transcription]; Region: COG1959 1266738009482 transcriptional repressor NsrR; Provisional; Region: PRK11014 1266738009483 exoribonuclease R; Provisional; Region: PRK11642 1266738009484 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1266738009485 RNB domain; Region: RNB; pfam00773 1266738009486 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1266738009487 RNA binding site [nucleotide binding]; other site 1266738009488 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1266738009489 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1266738009490 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1266738009491 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1266738009492 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1266738009493 dimer interface [polypeptide binding]; other site 1266738009494 ssDNA binding site [nucleotide binding]; other site 1266738009495 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1266738009496 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1266738009497 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1266738009498 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1266738009499 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1266738009500 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1266738009501 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1266738009502 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1266738009503 YodA lipocalin-like domain; Region: YodA; cl01365 1266738009504 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1266738009505 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1266738009506 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1266738009507 Probable transposase; Region: OrfB_IS605; pfam01385 1266738009508 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1266738009509 succinic semialdehyde dehydrogenase; Region: PLN02278 1266738009510 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1266738009511 tetramerization interface [polypeptide binding]; other site 1266738009512 NAD(P) binding site [chemical binding]; other site 1266738009513 catalytic residues [active] 1266738009514 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1266738009515 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1266738009516 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1266738009517 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1266738009518 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1266738009519 active site 1266738009520 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 1266738009521 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1266738009522 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1266738009523 Domain of unknown function DUF21; Region: DUF21; pfam01595 1266738009524 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1266738009525 Transporter associated domain; Region: CorC_HlyC; smart01091 1266738009526 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1266738009527 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1266738009528 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1266738009529 Surface antigen; Region: Bac_surface_Ag; pfam01103 1266738009530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1266738009531 Dicarboxylate transport; Region: DctA-YdbH; cl14674 1266738009532 Family of unknown function (DUF490); Region: DUF490; pfam04357 1266738009533 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1266738009534 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1266738009535 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1266738009536 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1266738009537 dimer interface [polypeptide binding]; other site 1266738009538 substrate binding site [chemical binding]; other site 1266738009539 metal binding sites [ion binding]; metal-binding site 1266738009540 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1266738009541 AMP binding site [chemical binding]; other site 1266738009542 metal binding site [ion binding]; metal-binding site 1266738009543 active site 1266738009544 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1266738009545 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1266738009546 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1266738009547 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1266738009548 arginine repressor; Provisional; Region: PRK05066 1266738009549 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1266738009550 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1266738009551 malate dehydrogenase; Provisional; Region: PRK05086 1266738009552 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1266738009553 NAD binding site [chemical binding]; other site 1266738009554 dimerization interface [polypeptide binding]; other site 1266738009555 Substrate binding site [chemical binding]; other site 1266738009556 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 1266738009557 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 1266738009558 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 1266738009559 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1266738009560 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1266738009561 substrate binding pocket [chemical binding]; other site 1266738009562 chain length determination region; other site 1266738009563 substrate-Mg2+ binding site; other site 1266738009564 catalytic residues [active] 1266738009565 aspartate-rich region 1; other site 1266738009566 active site lid residues [active] 1266738009567 aspartate-rich region 2; other site 1266738009568 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1266738009569 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1266738009570 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1266738009571 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1266738009572 GTP1/OBG; Region: GTP1_OBG; pfam01018 1266738009573 Obg GTPase; Region: Obg; cd01898 1266738009574 G1 box; other site 1266738009575 GTP/Mg2+ binding site [chemical binding]; other site 1266738009576 Switch I region; other site 1266738009577 G2 box; other site 1266738009578 G3 box; other site 1266738009579 Switch II region; other site 1266738009580 G4 box; other site 1266738009581 G5 box; other site 1266738009582 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1266738009583 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1266738009584 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1266738009585 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1266738009586 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1266738009587 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 1266738009588 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1266738009589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738009590 S-adenosylmethionine binding site [chemical binding]; other site 1266738009591 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1266738009592 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1266738009593 Walker A motif; other site 1266738009594 ATP binding site [chemical binding]; other site 1266738009595 Walker B motif; other site 1266738009596 arginine finger; other site 1266738009597 Peptidase family M41; Region: Peptidase_M41; pfam01434 1266738009598 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1266738009599 dihydropteroate synthase; Region: DHPS; TIGR01496 1266738009600 substrate binding pocket [chemical binding]; other site 1266738009601 dimer interface [polypeptide binding]; other site 1266738009602 inhibitor binding site; inhibition site 1266738009603 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1266738009604 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1266738009605 active site 1266738009606 substrate binding site [chemical binding]; other site 1266738009607 metal binding site [ion binding]; metal-binding site 1266738009608 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1266738009609 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1266738009610 Sm and related proteins; Region: Sm_like; cl00259 1266738009611 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1266738009612 putative oligomer interface [polypeptide binding]; other site 1266738009613 putative RNA binding site [nucleotide binding]; other site 1266738009614 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1266738009615 NusA N-terminal domain; Region: NusA_N; pfam08529 1266738009616 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1266738009617 RNA binding site [nucleotide binding]; other site 1266738009618 homodimer interface [polypeptide binding]; other site 1266738009619 NusA-like KH domain; Region: KH_5; pfam13184 1266738009620 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1266738009621 G-X-X-G motif; other site 1266738009622 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1266738009623 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1266738009624 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1266738009625 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1266738009626 translation initiation factor IF-2; Region: IF-2; TIGR00487 1266738009627 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1266738009628 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1266738009629 G1 box; other site 1266738009630 putative GEF interaction site [polypeptide binding]; other site 1266738009631 GTP/Mg2+ binding site [chemical binding]; other site 1266738009632 Switch I region; other site 1266738009633 G2 box; other site 1266738009634 G3 box; other site 1266738009635 Switch II region; other site 1266738009636 G4 box; other site 1266738009637 G5 box; other site 1266738009638 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1266738009639 Translation-initiation factor 2; Region: IF-2; pfam11987 1266738009640 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1266738009641 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1266738009642 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1266738009643 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1266738009644 RNA binding site [nucleotide binding]; other site 1266738009645 active site 1266738009646 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1266738009647 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1266738009648 16S/18S rRNA binding site [nucleotide binding]; other site 1266738009649 S13e-L30e interaction site [polypeptide binding]; other site 1266738009650 25S rRNA binding site [nucleotide binding]; other site 1266738009651 lipoprotein NlpI; Provisional; Region: PRK11189 1266738009652 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1266738009653 binding surface 1266738009654 TPR motif; other site 1266738009655 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 1266738009656 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1266738009657 ATP binding site [chemical binding]; other site 1266738009658 Mg++ binding site [ion binding]; other site 1266738009659 motif III; other site 1266738009660 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1266738009661 nucleotide binding region [chemical binding]; other site 1266738009662 ATP-binding site [chemical binding]; other site 1266738009663 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1266738009664 putative RNA binding site [nucleotide binding]; other site 1266738009665 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1266738009666 Sel1-like repeats; Region: SEL1; smart00671 1266738009667 hypothetical protein; Provisional; Region: PRK10039 1266738009668 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1266738009669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1266738009670 active site 1266738009671 phosphorylation site [posttranslational modification] 1266738009672 intermolecular recognition site; other site 1266738009673 dimerization interface [polypeptide binding]; other site 1266738009674 LytTr DNA-binding domain; Region: LytTR; pfam04397 1266738009675 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1266738009676 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1266738009677 GAF domain; Region: GAF; pfam01590 1266738009678 Histidine kinase; Region: His_kinase; pfam06580 1266738009679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1266738009680 ATP binding site [chemical binding]; other site 1266738009681 Mg2+ binding site [ion binding]; other site 1266738009682 G-X-G motif; other site 1266738009683 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1266738009684 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1266738009685 HlyD family secretion protein; Region: HlyD_3; pfam13437 1266738009686 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1266738009687 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1266738009688 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1266738009689 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1266738009690 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1266738009691 Fimbrial protein; Region: Fimbrial; cl01416 1266738009692 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1266738009693 PapC N-terminal domain; Region: PapC_N; pfam13954 1266738009694 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1266738009695 PapC C-terminal domain; Region: PapC_C; pfam13953 1266738009696 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1266738009697 putative protease; Provisional; Region: PRK15447 1266738009698 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1266738009699 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1266738009700 Peptidase family U32; Region: Peptidase_U32; pfam01136 1266738009701 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1266738009702 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1266738009703 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1266738009704 Coenzyme A binding pocket [chemical binding]; other site 1266738009705 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1266738009706 GIY-YIG motif/motif A; other site 1266738009707 putative active site [active] 1266738009708 putative metal binding site [ion binding]; other site 1266738009709 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1266738009710 hypothetical protein; Provisional; Region: PRK03467 1266738009711 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 1266738009712 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1266738009713 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1266738009714 FeS/SAM binding site; other site 1266738009715 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1266738009716 ATP cone domain; Region: ATP-cone; pfam03477 1266738009717 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1266738009718 effector binding site; other site 1266738009719 active site 1266738009720 Zn binding site [ion binding]; other site 1266738009721 glycine loop; other site 1266738009722 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1266738009723 homotrimer interaction site [polypeptide binding]; other site 1266738009724 putative active site [active] 1266738009725 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1266738009726 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1266738009727 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1266738009728 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 1266738009729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1266738009730 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1266738009731 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1266738009732 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1266738009733 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1266738009734 RNase E inhibitor protein; Provisional; Region: PRK11191 1266738009735 Pirin-related protein [General function prediction only]; Region: COG1741 1266738009736 Pirin; Region: Pirin; pfam02678 1266738009737 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1266738009738 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 1266738009739 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1266738009740 Coenzyme A binding pocket [chemical binding]; other site 1266738009741 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1266738009742 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1266738009743 HIGH motif; other site 1266738009744 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1266738009745 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1266738009746 active site 1266738009747 KMSKS motif; other site 1266738009748 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1266738009749 tRNA binding surface [nucleotide binding]; other site 1266738009750 anticodon binding site; other site 1266738009751 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1266738009752 DNA polymerase III subunit chi; Validated; Region: PRK05728 1266738009753 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1266738009754 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1266738009755 interface (dimer of trimers) [polypeptide binding]; other site 1266738009756 Substrate-binding/catalytic site; other site 1266738009757 Zn-binding sites [ion binding]; other site 1266738009758 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 1266738009759 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1266738009760 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1266738009761 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1266738009762 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1266738009763 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 1266738009764 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1266738009765 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1266738009766 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1266738009767 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1266738009768 Probable transposase; Region: OrfB_IS605; pfam01385 1266738009769 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1266738009770 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 1266738009771 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1266738009772 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738009773 non-specific DNA binding site [nucleotide binding]; other site 1266738009774 salt bridge; other site 1266738009775 sequence-specific DNA binding site [nucleotide binding]; other site 1266738009776 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 1266738009777 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1266738009778 hypothetical protein; Reviewed; Region: PRK09588 1266738009779 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 1266738009780 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1266738009781 intersubunit interface [polypeptide binding]; other site 1266738009782 active site 1266738009783 catalytic residue [active] 1266738009784 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1266738009785 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1266738009786 substrate binding site [chemical binding]; other site 1266738009787 dimer interface [polypeptide binding]; other site 1266738009788 ATP binding site [chemical binding]; other site 1266738009789 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1266738009790 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1266738009791 putative active site [active] 1266738009792 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1266738009793 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1266738009794 active site turn [active] 1266738009795 phosphorylation site [posttranslational modification] 1266738009796 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1266738009797 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1266738009798 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1266738009799 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1266738009800 putative active site [active] 1266738009801 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1266738009802 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1266738009803 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1266738009804 PYR/PP interface [polypeptide binding]; other site 1266738009805 dimer interface [polypeptide binding]; other site 1266738009806 TPP binding site [chemical binding]; other site 1266738009807 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1266738009808 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1266738009809 TPP-binding site [chemical binding]; other site 1266738009810 dimer interface [polypeptide binding]; other site 1266738009811 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1266738009812 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1266738009813 putative valine binding site [chemical binding]; other site 1266738009814 dimer interface [polypeptide binding]; other site 1266738009815 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1266738009816 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1266738009817 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1266738009818 non-specific DNA binding site [nucleotide binding]; other site 1266738009819 salt bridge; other site 1266738009820 sequence-specific DNA binding site [nucleotide binding]; other site 1266738009821 Cupin domain; Region: Cupin_2; cl17218 1266738009822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738009823 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1266738009824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1266738009825 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1266738009826 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1266738009827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1266738009828 Coenzyme A binding pocket [chemical binding]; other site 1266738009829 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1266738009830 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1266738009831 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1266738009832 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1266738009833 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1266738009834 putative dimerization interface [polypeptide binding]; other site 1266738009835 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1266738009836 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1266738009837 THF binding site; other site 1266738009838 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1266738009839 substrate binding site [chemical binding]; other site 1266738009840 THF binding site; other site 1266738009841 zinc-binding site [ion binding]; other site 1266738009842 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 1266738009843 uridine phosphorylase; Provisional; Region: PRK11178 1266738009844 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1266738009845 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1266738009846 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1266738009847 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1266738009848 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1266738009849 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 1266738009850 RmuC family; Region: RmuC; pfam02646 1266738009851 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1266738009852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1266738009853 S-adenosylmethionine binding site [chemical binding]; other site 1266738009854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1266738009855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1266738009856 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1266738009857 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1266738009858 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1266738009859 twin arginine translocase protein A; Provisional; Region: tatA; PRK04598 1266738009860 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1266738009861 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 1266738009862 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1266738009863 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1266738009864 active site pocket [active] 1266738009865 oxyanion hole [active] 1266738009866 catalytic triad [active] 1266738009867 active site nucleophile [active] 1266738009868 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 1266738009869 FMN reductase; Validated; Region: fre; PRK08051 1266738009870 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1266738009871 FAD binding pocket [chemical binding]; other site 1266738009872 FAD binding motif [chemical binding]; other site 1266738009873 phosphate binding motif [ion binding]; other site 1266738009874 beta-alpha-beta structure motif; other site 1266738009875 NAD binding pocket [chemical binding]; other site 1266738009876 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1266738009877 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1266738009878 dimer interface [polypeptide binding]; other site 1266738009879 active site 1266738009880 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1266738009881 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1266738009882 substrate binding site [chemical binding]; other site 1266738009883 oxyanion hole (OAH) forming residues; other site 1266738009884 trimer interface [polypeptide binding]; other site 1266738009885 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1266738009886 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1266738009887 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1266738009888 proline dipeptidase; Provisional; Region: PRK13607 1266738009889 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1266738009890 active site 1266738009891 hypothetical protein; Provisional; Region: PRK11568 1266738009892 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1266738009893 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1266738009894 potassium transporter; Provisional; Region: PRK10750 1266738009895 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1266738009896 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104