-- dump date 20140620_001442 -- class Genbank::misc_feature -- table misc_feature_note -- id note 529507000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 529507000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 529507000003 putative catalytic residues [active] 529507000004 putative nucleotide binding site [chemical binding]; other site 529507000005 putative aspartate binding site [chemical binding]; other site 529507000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 529507000007 dimer interface [polypeptide binding]; other site 529507000008 putative threonine allosteric regulatory site; other site 529507000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 529507000010 putative threonine allosteric regulatory site; other site 529507000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 529507000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 529507000013 HMMPfam hit to PF00696, amino acid kinase family, score 1.3e-58 529507000014 PS00324 aspartokinase signature. 529507000015 HMMPfam hit to PF01842, ACT domain, score 3.8e-10 529507000016 HMMPfam hit to PF01842, ACT domain, score 0.0001 529507000017 HMMPfam hit to PF03447, homoserine dehydrogenase, NAD binding d, score 7.5e-51 529507000018 HMMPfam hit to PF00742, homoserine dehydrogenase, score 8.9e-93 529507000019 PS00017 ATP/GTP-binding site motif A (P-loop). 529507000020 PS01042 homoserine dehydrogenase signature. 529507000021 homoserine kinase; Provisional; Region: PRK01212 529507000022 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 529507000023 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 529507000024 HMMPfam hit to PF00288, GHMP kinases ATP-binding protei, score 2.5e-36 529507000025 PS00627 GHMP kinases ATP-binding domain. 529507000026 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507000027 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 529507000028 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 529507000029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507000030 catalytic residue [active] 529507000031 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 5.7e-30 529507000032 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 529507000033 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 529507000034 PS00141 Eukaryotic and viral aspartyl proteases active site. 529507000035 2 probable transmembrane helices predicted for PMI0004 by TMHMM2.0 at aa 1705-1727 and 1732-1754 529507000036 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 5.6 529507000037 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 6.2 529507000038 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.072 529507000039 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 2.4 529507000040 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.011 529507000041 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.48 529507000042 hypothetical protein; Validated; Region: PRK02101 529507000043 HMMPfam hit to PF03883, Protein of unknown function (DUF328), score 3.4e-167 529507000044 transaldolase-like protein; Provisional; Region: PTZ00411 529507000045 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 529507000046 active site 529507000047 dimer interface [polypeptide binding]; other site 529507000048 catalytic residue [active] 529507000049 HMMPfam hit to PF00923, Transaldolase, score 2.5e-174 529507000050 PS01054 Transaldolase signature 1. 529507000051 PS00958 Transaldolase active site. 529507000052 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 529507000053 Sel1-like repeats; Region: SEL1; smart00671 529507000054 Sel1-like repeats; Region: SEL1; smart00671 529507000055 Sel1-like repeats; Region: SEL1; smart00671 529507000056 Sel1-like repeats; Region: SEL1; smart00671 529507000057 Sel1-like repeats; Region: SEL1; smart00671 529507000058 Sel1-like repeats; Region: SEL1; smart00671 529507000059 Sel1-like repeats; Region: SEL1; smart00671 529507000060 Signal peptide predicted for PMI0007 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.975 between residues 21 and 22 529507000061 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 529507000062 MPT binding site; other site 529507000063 trimer interface [polypeptide binding]; other site 529507000064 HMMPfam hit to PF00994, Probable molybdopterin binding domain, score 4.5e-41 529507000065 PS01078 Molybdenum cofactor biosynthesis proteins signature 1. 529507000066 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 529507000067 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 529507000068 nucleotide binding site [chemical binding]; other site 529507000069 HMMPfam hit to PF00012, Hsp70 protein, score 0 529507000070 PS00297 Heat shock hsp70 proteins family signature 1. 529507000071 PS00329 Heat shock hsp70 proteins family signature 2. 529507000072 PS01036 Heat shock hsp70 proteins family signature 3. 529507000073 chaperone protein DnaJ; Provisional; Region: PRK10767 529507000074 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 529507000075 HSP70 interaction site [polypeptide binding]; other site 529507000076 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 529507000077 substrate binding site [polypeptide binding]; other site 529507000078 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 529507000079 Zn binding sites [ion binding]; other site 529507000080 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 529507000081 dimer interface [polypeptide binding]; other site 529507000082 HMMPfam hit to PF00226, DnaJ domain, score 7.5e-41 529507000083 PS00636 Nt-dnaJ domain signature. 529507000084 HMMPfam hit to PF00684, DnaJ central domain (4 repeats), score 1.4e-41 529507000085 PS00637 CXXCXGXG dnaJ domain signature. 529507000086 PS00190 Cytochrome c family heme-binding site signature. 529507000087 PS00190 Cytochrome c family heme-binding site signature. 529507000088 PS00190 Cytochrome c family heme-binding site signature. 529507000089 HMMPfam hit to PF01556, DnaJ C terminal region, score 1.2e-77 529507000090 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 529507000091 Signal peptide predicted for PMI0011 by SignalP 2.0 HMM (Signal peptide probability 0.952) with cleavage site probability 0.719 between residues 30 and 31 529507000092 HMMPfam hit to PF06965, Na+/H+ antiporter, score 3.9e-234 529507000093 11 probable transmembrane helices predicted for PMI0011 by TMHMM2.0 at aa 16-38, 58-77, 94-116, 126-145, 152-174, 179-199, 206-237, 257-279, 286-308, 328-350 and 363-385 529507000094 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 529507000095 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507000096 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 529507000097 putative dimerization interface [polypeptide binding]; other site 529507000098 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix protei, score 5.7e-19 529507000099 PS00044 Bacterial regulatory proteins, lysR family signature. 529507000100 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 529507000101 HMMPfam hit to PF01649, Ribosomal protein S20, score 4.7e-44 529507000102 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 529507000103 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 529507000104 active site 529507000105 Riboflavin kinase; Region: Flavokinase; smart00904 529507000106 HMMPfam hit to PF06574, Riboflavin kinase (Flavokinase), score 3.3e-92 529507000107 HMMPfam hit to PF01687, Riboflavin kinase / FAD synthetase, score 2.7e-60 529507000108 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 529507000109 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 529507000110 active site 529507000111 HIGH motif; other site 529507000112 nucleotide binding site [chemical binding]; other site 529507000113 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 529507000114 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 529507000115 active site 529507000116 KMSKS motif; other site 529507000117 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 529507000118 tRNA binding surface [nucleotide binding]; other site 529507000119 anticodon binding site; other site 529507000120 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 529507000121 HMMPfam hit to PF00133, tRNA synthetases class I (I, L, M and V), score 0 529507000122 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 529507000123 HMMPfam hit to PF06827, Zinc finger found in FPG and IleRS, score 1.6e-13 529507000124 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 529507000125 lipoprotein signal peptidase; Provisional; Region: PRK14787 529507000126 HMMPfam hit to PF01252, Signal peptidase (SPase) II, score 2.7e-75 529507000127 4 probable transmembrane helices predicted for PMI0016 by TMHMM2.0 at aa 13-35, 68-87, 100-122 and 137-159 529507000128 PS00327 Bacterial rhodopsins retinal binding site. 529507000129 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 529507000130 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 529507000131 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 9.4e-05 529507000132 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 529507000133 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 529507000134 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 529507000135 HMMPfam hit to PF02401, LytB protein, score 1e-177 529507000136 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 529507000137 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 529507000138 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 529507000139 HMMPfam hit to PF01113, Dihydrodipicolinate reductase, N-terminus, score 2.8e-58 529507000140 HMMPfam hit to PF05173, Dihydrodipicolinate reductase, C-terminus, score 2e-77 529507000141 PS01298 Dihydrodipicolinate reductase signature. 529507000142 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 529507000143 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 529507000144 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 529507000145 catalytic site [active] 529507000146 subunit interface [polypeptide binding]; other site 529507000147 HMMPfam hit to PF00988, Carbamoyl-phosphate synthase small ch, score 1.1e-91 529507000148 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 1.8e-75 529507000149 PS00442 Glutamine amidotransferases class-I active site. 529507000150 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 529507000151 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 529507000152 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 529507000153 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 529507000154 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 529507000155 ATP-grasp domain; Region: ATP-grasp_4; cl17255 529507000156 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 529507000157 IMP binding site; other site 529507000158 dimer interface [polypeptide binding]; other site 529507000159 interdomain contacts; other site 529507000160 partial ornithine binding site; other site 529507000161 Signal peptide predicted for PMI0021 by SignalP 2.0 HMM (Signal peptide probability 0.936) with cleavage site probability 0.838 between residues 26 and 27 529507000162 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 4e-63 529507000163 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507000164 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 7.5e-135 529507000165 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 529507000166 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 529507000167 HMMPfam hit to PF02787, Carbamoyl-phosphate synthetase large c, score 9.9e-68 529507000168 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 1.1e-26 529507000169 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 9.3e-29 529507000170 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 529507000171 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 529507000172 HMMPfam hit to PF02142, MGS-like domain, score 1.6e-32 529507000173 Hok/gef family; Region: HOK_GEF; pfam01848 529507000174 HMMPfam hit to PF01848, Hok/gef family, score 2.3e-07 529507000175 1 probable transmembrane helix predicted for PMI0022 by TMHMM2.0 at aa 4-23 529507000176 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 529507000177 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 529507000178 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 529507000179 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 529507000180 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 529507000181 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 529507000182 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 529507000183 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 529507000184 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 529507000185 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 529507000186 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 0.00024 529507000187 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 2.6e-07 529507000188 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 4.2e-07 529507000189 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 2.8e-07 529507000190 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 1.4e-08 529507000191 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 1.9e-09 529507000192 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 1.1e-07 529507000193 Predicted helix-turn-helix motif with score 1048.000, SD 2.76 at aa 154-175, sequence VTQYAISQISSKSNQKIEQWLN 529507000194 HMMPfam hit to PF01476, LysM domain, score 0.00023 529507000195 Signal peptide predicted for PMI0023 by SignalP 2.0 HMM (Signal peptide probability 0.947) with cleavage site probability 0.946 between residues 46 and 47 529507000196 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 529507000197 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 529507000198 active site 529507000199 catalytic tetrad [active] 529507000200 HMMPfam hit to PF00248, Aldo/keto reductase family, score 2.6e-127 529507000201 PS00063 Aldo/keto reductase family active site signature. 529507000202 PS00062 Aldo/keto reductase family signature 2. 529507000203 PS00798 Aldo/keto reductase family signature 1. 529507000204 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 529507000205 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 529507000206 dimer interface [polypeptide binding]; other site 529507000207 active site 529507000208 metal binding site [ion binding]; metal-binding site 529507000209 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 2.7e-35 529507000210 PS00060 Iron-containing alcohol dehydrogenases signature 2. 529507000211 PS00913 Iron-containing alcohol dehydrogenases signature 1. 529507000212 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 529507000213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507000214 S-adenosylmethionine binding site [chemical binding]; other site 529507000215 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 529507000216 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 529507000217 5 probable transmembrane helices predicted for PMI0027 by TMHMM2.0 at aa 30-52, 72-94, 129-151, 161-183 and 196-218 529507000218 HMMPfam hit to PF00597, DedA family, score 5.9e-42 529507000219 cystathionine beta-lyase; Provisional; Region: PRK08114 529507000220 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 529507000221 homodimer interface [polypeptide binding]; other site 529507000222 substrate-cofactor binding pocket; other site 529507000223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507000224 catalytic residue [active] 529507000225 HMMPfam hit to PF01053, Cys/Met metabolism PLP-dependent enzy, score 2.7e-134 529507000226 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 529507000227 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 529507000228 Signal peptide predicted for PMI0029 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21 529507000229 3 probable transmembrane helices predicted for PMI0029 by TMHMM2.0 at aa 130-152, 235-257 and 281-303 529507000230 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 7.7e-50 529507000231 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 529507000232 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 529507000233 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 2.4e-20 529507000234 1 probable transmembrane helix predicted for PMI0030 by TMHMM2.0 at aa 20-42 529507000235 hydrogenase 2 small subunit; Provisional; Region: PRK10468 529507000236 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 529507000237 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 529507000238 Signal peptide predicted for PMI0031 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.832 between residues 37 and 38 529507000239 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 Kd sub, score 1.8e-05 529507000240 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507000241 1 probable transmembrane helix predicted for PMI0031 by TMHMM2.0 at aa 334-356 529507000242 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 529507000243 4Fe-4S binding domain; Region: Fer4; cl02805 529507000244 Signal peptide predicted for PMI0032 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.983 between residues 26 and 27 529507000245 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.008 529507000246 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 9.3e-05 529507000247 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507000248 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 529507000249 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 529507000250 10 probable transmembrane helices predicted for PMI0033 by TMHMM2.0 at aa 13-32, 52-74, 87-109, 131-153, 174-196, 211-233, 246-268, 283-302, 315-337 and 352-374 529507000251 hydrogenase 2 large subunit; Provisional; Region: PRK10467 529507000252 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 529507000253 HMMPfam hit to PF00374, Nickel-dependent hydrogenase, score 1e-263 529507000254 PS00507 Nickel-dependent hydrogenases large subunit signature 1. 529507000255 PS00508 Nickel-dependent hydrogenases large subunit signature 2. 529507000256 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 529507000257 putative substrate-binding site; other site 529507000258 nickel binding site [ion binding]; other site 529507000259 HMMPfam hit to PF01750, Hydrogenase maturation protease, score 5.1e-36 529507000260 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 529507000261 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 529507000262 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 529507000263 HMMPfam hit to PF02492, CobW/HypB/UreG, nucleotide-binding domain, score 1.3e-71 529507000264 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 529507000265 HMMPfam hit to PF01455, HupF/HypC family, score 2.3e-28 529507000266 PS01097 Hydrogenases expression/synthesis hupF/hypC family signature. 529507000267 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 529507000268 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 529507000269 HMMPfam hit to PF01924, Hydrogenase formation hypA family, score 2.1e-224 529507000270 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507000271 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 529507000272 dimerization interface [polypeptide binding]; other site 529507000273 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 529507000274 ATP binding site [chemical binding]; other site 529507000275 HMMPfam hit to PF00586, AIR synthase related protein, N-terminal dom, score 7e-40 529507000276 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 7.6e-35 529507000277 putative inner membrane protein; Provisional; Region: PRK11099 529507000278 Sulphur transport; Region: Sulf_transp; pfam04143 529507000279 Signal peptide predicted for PMI0041 by SignalP 2.0 HMM (Signal peptide probability 0.898) with cleavage site probability 0.446 between residues 33 and 34 529507000280 10 probable transmembrane helices predicted for PMI0041 by TMHMM2.0 at aa 21-43, 81-103, 116-138, 148-170, 197-216, 221-238, 259-281, 286-308, 321-341 and 361-383 529507000281 HMMPfam hit to PF04143, YeeE/YedE family (DUF395), score 9.7e-20 529507000282 HMMPfam hit to PF04143, YeeE/YedE family (DUF395), score 3.9e-22 529507000283 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 529507000284 CPxP motif; other site 529507000285 HMMPfam hit to PF01206, SirA-like protein, score 5.2e-41 529507000286 PS01148 Uncharacterized protein family UPF0033 signature. 529507000287 recombination associated protein; Reviewed; Region: rdgC; PRK00321 529507000288 HMMPfam hit to PF04381, exonuclease, RdgC, score 4.7e-187 529507000289 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 529507000290 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 529507000291 eyelet of channel; other site 529507000292 trimer interface [polypeptide binding]; other site 529507000293 Signal peptide predicted for PMI0044 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 27 and 28 529507000294 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 529507000295 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 529507000296 active site 529507000297 metal binding site [ion binding]; metal-binding site 529507000298 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 529507000299 Signal peptide predicted for PMI0045 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 21 and 22 529507000300 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 8.4e-18 529507000301 PS00785 5'-nucleotidase signature 1. 529507000302 HMMPfam hit to PF02872, 5'-nucleotidase, C-terminal domain, score 1.5e-56 529507000303 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208 529507000304 CAS motifs; other site 529507000305 active site 529507000306 Signal peptide predicted for PMI0046 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.596 between residues 21 and 22 529507000307 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507000308 PS00017 ATP/GTP-binding site motif A (P-loop). 529507000309 PS00531 Ribonuclease T2 family histidine active site 2. 529507000310 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 529507000311 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 529507000312 putative active site [active] 529507000313 putative metal binding site [ion binding]; other site 529507000314 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 529507000315 Signal peptide predicted for PMI0047 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.615 between residues 23 and 24 529507000316 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507000317 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 2.1e-11 529507000318 HMMPfam hit to PF02872, 5'-nucleotidase, C-terminal domain, score 3.9e-41 529507000319 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 529507000320 dimer interface [polypeptide binding]; other site 529507000321 FMN binding site [chemical binding]; other site 529507000322 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507000323 AAA domain; Region: AAA_23; pfam13476 529507000324 Walker A/P-loop; other site 529507000325 ATP binding site [chemical binding]; other site 529507000326 Q-loop/lid; other site 529507000327 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507000328 ABC transporter signature motif; other site 529507000329 Walker B; other site 529507000330 D-loop; other site 529507000331 H-loop/switch region; other site 529507000332 HMMPfam hit to PF00904, no description, score 1.9e+02 529507000333 HMMPfam hit to PF00904, no description, score 3.7e+02 529507000334 HMMPfam hit to PF00904, no description, score 1.5e+02 529507000335 Predicted helix-turn-helix motif with score 1072.000, SD 2.84 at aa 762-783, sequence KTYQQQSEHLHQQQQQLAQHIQ 529507000336 HMMPfam hit to PF00904, no description, score 2.9e+02 529507000337 HMMPfam hit to PF00904, no description, score 2.4e+02 529507000338 HMMPfam hit to PF00904, no description, score 1.8e+02 529507000339 HMMPfam hit to PF00904, no description, score 91 529507000340 HMMPfam hit to PF00904, no description, score 1e+02 529507000341 HMMPfam hit to PF00904, no description, score 2.8e+02 529507000342 HMMPfam hit to PF02463, RecF/RecN/SMC N terminal domain, score 2.2e-05 529507000343 PS00017 ATP/GTP-binding site motif A (P-loop). 529507000344 exonuclease subunit SbcD; Provisional; Region: PRK10966 529507000345 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 529507000346 active site 529507000347 metal binding site [ion binding]; metal-binding site 529507000348 DNA binding site [nucleotide binding] 529507000349 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 529507000350 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 6.9e-18 529507000351 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 529507000352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507000353 active site 529507000354 phosphorylation site [posttranslational modification] 529507000355 intermolecular recognition site; other site 529507000356 dimerization interface [polypeptide binding]; other site 529507000357 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 529507000358 DNA binding site [nucleotide binding] 529507000359 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.5e-35 529507000360 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 2.8e-25 529507000361 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 529507000362 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 529507000363 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 529507000364 putative active site [active] 529507000365 heme pocket [chemical binding]; other site 529507000366 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 529507000367 dimer interface [polypeptide binding]; other site 529507000368 phosphorylation site [posttranslational modification] 529507000369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 529507000370 ATP binding site [chemical binding]; other site 529507000371 Mg2+ binding site [ion binding]; other site 529507000372 G-X-G motif; other site 529507000373 Signal peptide predicted for PMI0052 by SignalP 2.0 HMM (Signal peptide probability 0.861) with cleavage site probability 0.777 between residues 23 and 24 529507000374 1 probable transmembrane helix predicted for PMI0052 by TMHMM2.0 at aa 12-34 529507000375 HMMPfam hit to PF00989, PAS domain, score 7.1e-06 529507000376 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 2.7e-25 529507000377 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 4.7e-39 529507000378 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 529507000379 Signal peptide predicted for PMI0053 by SignalP 2.0 HMM (Signal peptide probability 0.894) with cleavage site probability 0.802 between residues 24 and 25 529507000380 HMMPfam hit to PF05525, Branched-chain amino acid transport p, score 1.8e-215 529507000381 12 probable transmembrane helices predicted for PMI0053 by TMHMM2.0 at aa 13-35, 40-62, 83-105, 120-139, 151-173, 188-210, 223-245, 278-300, 312-334, 339-361, 368-387 and 410-427 529507000382 HipA N-terminal domain; Region: Couple_hipA; pfam13657 529507000383 HipA-like N-terminal domain; Region: HipA_N; pfam07805 529507000384 HipA-like C-terminal domain; Region: HipA_C; pfam07804 529507000385 HMMPfam hit to PF07804, HipA-like C-terminal domain, score 3.7e-25 529507000386 HMMPfam hit to PF07805, HipA-like N-terminal domain, score 6e-06 529507000387 2 probable transmembrane helices predicted for PMI0056 by TMHMM2.0 at aa 63-85 and 149-171 529507000388 2 probable transmembrane helices predicted for PMI0057 by TMHMM2.0 at aa 57-79 and 149-171 529507000389 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507000390 membrane protein (pseudogene);Highly similar to PMI0056, PMI0057, PMI0060, PMI0061, PMI0062 and PMI0063; This CDS contains an in frame TAG stop codon. 529507000391 1 probable transmembrane helix predicted for PMI0059 by TMHMM2.0 at aa 57-79 529507000392 2 probable transmembrane helices predicted for PMI0060 by TMHMM2.0 at aa 57-79 and 144-166 529507000393 2 probable transmembrane helices predicted for PMI0061 by TMHMM2.0 at aa 57-79 and 149-171 529507000394 2 probable transmembrane helices predicted for PMI0062 by TMHMM2.0 at aa 57-79 and 149-171 529507000395 2 probable transmembrane helices predicted for PMI0063 by TMHMM2.0 at aa 57-79 and 150-172 529507000396 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 529507000397 HMMPfam hit to PF06092, Enterobacterial membrane protein (D, score 4e-26 529507000398 1 probable transmembrane helix predicted for PMI0064 by TMHMM2.0 at aa 7-26 529507000399 hypothetical protein; Provisional; Region: PRK09946 529507000400 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 529507000401 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 529507000402 HMMPfam hit to PF01292, Cytochrome b561 family, score 0.00014 529507000403 5 probable transmembrane helices predicted for PMI0066 by TMHMM2.0 at aa 31-53, 80-102, 117-139, 187-206 and 221-243 529507000404 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 529507000405 4Fe-4S binding domain; Region: Fer4; cl02805 529507000406 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 9.1e-07 529507000407 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507000408 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.0011 529507000409 1 probable transmembrane helix predicted for PMI0067 by TMHMM2.0 at aa 7-29 529507000410 Signal peptide predicted for PMI0067 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.954 between residues 27 and 28 529507000411 hypothetical protein; Provisional; Region: PRK09947 529507000412 putative oxidoreductase; Provisional; Region: PRK09849 529507000413 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 529507000414 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 529507000415 HMMPfam hit to PF01314, Aldehyde ferredoxin oxidoreductase, domains, score 2.2e-201 529507000416 HMMPfam hit to PF02730, Aldehyde ferredoxin oxidoreductase, N-termin, score 6.5e-107 529507000417 hypothetical protein; Provisional; Region: PRK09898 529507000418 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 1.3e-05 529507000419 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507000420 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 4.1e-05 529507000421 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507000422 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.004 529507000423 PS00190 Cytochrome c family heme-binding site signature. 529507000424 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507000425 1 probable transmembrane helix predicted for PMI0071 by TMHMM2.0 at aa 13-32 529507000426 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 529507000427 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 529507000428 HMMPfam hit to PF01019, Gamma-glutamyltranspeptidase, score 2.7e-252 529507000429 PS00462 Gamma-glutamyltranspeptidase signature. 529507000430 peroxidase; Provisional; Region: PRK15000 529507000431 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 529507000432 dimer interface [polypeptide binding]; other site 529507000433 decamer (pentamer of dimers) interface [polypeptide binding]; other site 529507000434 catalytic triad [active] 529507000435 peroxidatic and resolving cysteines [active] 529507000436 HMMPfam hit to PF00578, AhpC/TSA family, score 3.3e-56 529507000437 Protein of unknown function, DUF479; Region: DUF479; cl01203 529507000438 HMMPfam hit to PF04336, Protein of unknown function, DUF479, score 6.2e-79 529507000439 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 529507000440 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 529507000441 HMMPfam hit to PF02547, Queuosine biosynthesis protein, score 1.3e-128 529507000442 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 529507000443 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 529507000444 HMMPfam hit to PF01702, Queuine tRNA-ribosyltransferase, score 3.3e-165 529507000445 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 529507000446 HMMPfam hit to PF02699, Preprotein translocase subunit, score 3.2e-43 529507000447 1 probable transmembrane helix predicted for PMI0077 by TMHMM2.0 at aa 20-42 529507000448 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 529507000449 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 529507000450 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 529507000451 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 529507000452 Signal peptide predicted for PMI0078 by SignalP 2.0 HMM (Signal peptide probability 0.967) with cleavage site probability 0.549 between residues 24 and 25 529507000453 6 probable transmembrane helices predicted for PMI0078 by TMHMM2.0 at aa 7-29, 450-472, 475-497, 502-524, 548-570 and 580-602 529507000454 HMMPfam hit to PF07549, SecD/SecF GG Motif, score 0.00054 529507000455 HMMPfam hit to PF02355, Protein export membrane protein, score 1.6e-06 529507000456 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 529507000457 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 529507000458 Protein export membrane protein; Region: SecD_SecF; pfam02355 529507000459 6 probable transmembrane helices predicted for PMI0079 by TMHMM2.0 at aa 39-58, 157-176, 183-205, 209-231, 262-284 and 289-311 529507000460 HMMPfam hit to PF07549, SecD/SecF GG Motif, score 8.4e-06 529507000461 HMMPfam hit to PF02355, Protein export membrane protein, score 3.2e-96 529507000462 PS00120 Lipases, serine active site. 529507000463 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 529507000464 ATP cone domain; Region: ATP-cone; pfam03477 529507000465 PS00190 Cytochrome c family heme-binding site signature. 529507000466 HMMPfam hit to PF03477, ATP cone domain, score 1.2e-31 529507000467 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 529507000468 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 529507000469 catalytic motif [active] 529507000470 Zn binding site [ion binding]; other site 529507000471 RibD C-terminal domain; Region: RibD_C; cl17279 529507000472 HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminase, score 4.3e-45 529507000473 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 529507000474 HMMPfam hit to PF01872, RibD C-terminal domain, score 8.3e-60 529507000475 PS00017 ATP/GTP-binding site motif A (P-loop). 529507000476 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 529507000477 homopentamer interface [polypeptide binding]; other site 529507000478 active site 529507000479 HMMPfam hit to PF00885, 6,7-dimethyl-8-ribityllumazine synthase, score 3.8e-88 529507000480 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 529507000481 putative RNA binding site [nucleotide binding]; other site 529507000482 HMMPfam hit to PF01029, NusB family, score 4.6e-45 529507000483 thiamine monophosphate kinase; Provisional; Region: PRK05731 529507000484 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 529507000485 ATP binding site [chemical binding]; other site 529507000486 dimerization interface [polypeptide binding]; other site 529507000487 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 0.0003 529507000488 hypothetical protein; Provisional; Region: PRK10220 529507000489 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 529507000490 PhnA protein; Region: PhnA; pfam03831 529507000491 HMMPfam hit to PF03831, PhnA protein, score 2.2e-36 529507000492 plasmid-associated protein (pseudogene);This CDS appears to have a frame shift mutation near the N-terminus. 529507000493 HMMPfam hit to PF01850, PIN domain, score 8.2e-22 529507000494 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 529507000495 HMMPfam hit to PF04014, SpoVT / AbrB like domain, score 0.0049 529507000496 transcriptional repressor RbsR; Provisional; Region: PRK10423 529507000497 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 529507000498 DNA binding site [nucleotide binding] 529507000499 domain linker motif; other site 529507000500 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 529507000501 dimerization interface [polypeptide binding]; other site 529507000502 ligand binding site [chemical binding]; other site 529507000503 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 2.7e-18 529507000504 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 9e-14 529507000505 Predicted helix-turn-helix motif with score 2156.000, SD 6.53 at aa 2-23, sequence ATMKDVARLAGVSTSTVSHVIN 529507000506 PS00356 Bacterial regulatory proteins, lacI family signature. 529507000507 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 529507000508 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 529507000509 substrate binding site [chemical binding]; other site 529507000510 dimer interface [polypeptide binding]; other site 529507000511 ATP binding site [chemical binding]; other site 529507000512 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 3.8e-93 529507000513 PS00584 pfkB family of carbohydrate kinases signature 2. 529507000514 PS00583 pfkB family of carbohydrate kinases signature 1. 529507000515 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 529507000516 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 529507000517 ligand binding site [chemical binding]; other site 529507000518 dimerization interface [polypeptide binding]; other site 529507000519 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 6.4e-10 529507000520 Signal peptide predicted for PMI0090 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 25 and 26 529507000521 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 529507000522 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 529507000523 TM-ABC transporter signature motif; other site 529507000524 HMMPfam hit to PF02653, Branched-chain amino acid transport syst, score 3.3e-75 529507000525 7 probable transmembrane helices predicted for PMI0091 by TMHMM2.0 at aa 23-45, 66-88, 98-120, 127-146, 170-192, 222-244 and 276-298 529507000526 Signal peptide predicted for PMI0091 by SignalP 2.0 HMM (Signal peptide probability 0.981) with cleavage site probability 0.441 between residues 43 and 44 529507000527 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 529507000528 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 529507000529 Walker A/P-loop; other site 529507000530 ATP binding site [chemical binding]; other site 529507000531 Q-loop/lid; other site 529507000532 ABC transporter signature motif; other site 529507000533 Walker B; other site 529507000534 D-loop; other site 529507000535 H-loop/switch region; other site 529507000536 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 529507000537 HMMPfam hit to PF00005, ABC transporter, score 3.8e-32 529507000538 PS00211 ABC transporters family signature. 529507000539 HMMPfam hit to PF00005, ABC transporter, score 3.9e-53 529507000540 PS00017 ATP/GTP-binding site motif A (P-loop). 529507000541 D-ribose pyranase; Provisional; Region: PRK11797 529507000542 HMMPfam hit to PF05025, RbsD / FucU transport protein family, score 2.8e-70 529507000543 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 529507000544 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 529507000545 TPP-binding site; other site 529507000546 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 529507000547 PYR/PP interface [polypeptide binding]; other site 529507000548 dimer interface [polypeptide binding]; other site 529507000549 TPP binding site [chemical binding]; other site 529507000550 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 529507000551 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 4.6e-41 529507000552 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 8.4e-63 529507000553 PS00802 Transketolase signature 2. 529507000554 PS00801 Transketolase signature 1. 529507000555 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 529507000556 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 529507000557 substrate binding pocket [chemical binding]; other site 529507000558 chain length determination region; other site 529507000559 substrate-Mg2+ binding site; other site 529507000560 catalytic residues [active] 529507000561 aspartate-rich region 1; other site 529507000562 active site lid residues [active] 529507000563 aspartate-rich region 2; other site 529507000564 HMMPfam hit to PF00348, Polyprenyl synthetase, score 1.7e-113 529507000565 PS00444 Polyprenyl synthetases signature 2. 529507000566 PS00723 Polyprenyl synthetases signature 1. 529507000567 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 529507000568 HMMPfam hit to PF02609, Exonuclease VII small subunit, score 1.1e-31 529507000569 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 529507000570 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 529507000571 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 529507000572 Ligand Binding Site [chemical binding]; other site 529507000573 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 529507000574 active site residue [active] 529507000575 HMMPfam hit to PF02926, THUMP domain, score 1.2e-20 529507000576 HMMPfam hit to PF02568, Thiamine biosynthesis protein (ThiI), score 3.2e-103 529507000577 conserved hypothetical protein (fragment);This CDS appears to be truncated at N-terminus relative to database matches. 529507000578 Signal peptide predicted for PMI0100 by SignalP 2.0 HMM (Signal peptide probability 0.871) with cleavage site probability 0.465 between residues 30 and 31 529507000579 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 529507000580 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 529507000581 conserved cys residue [active] 529507000582 HMMPfam hit to PF01965, DJ-1/PfpI family, score 2.4e-38 529507000583 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 529507000584 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 529507000585 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 529507000586 HMMPfam hit to PF02558, Ketopantoate reductase PanE/ApbA, score 3.6e-59 529507000587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 529507000588 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 529507000589 HMMPfam hit to PF04461, Protein of unknown function (DUF520), score 6.8e-111 529507000590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507000591 Major Facilitator Superfamily; Region: MFS_1; pfam07690 529507000592 putative substrate translocation pore; other site 529507000593 HMMPfam hit to PF00083, Sugar (and other) transporter, score 1.8e-05 529507000594 12 probable transmembrane helices predicted for PMI0104 by TMHMM2.0 at aa 13-35, 50-72, 79-98, 102-124, 137-159, 164-186, 217-239, 249-271, 280-302, 306-328, 340-362 and 367-389 529507000595 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.5e-55 529507000596 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 529507000597 UbiA prenyltransferase family; Region: UbiA; pfam01040 529507000598 HMMPfam hit to PF01040, UbiA prenyltransferase family, score 1.1e-80 529507000599 9 probable transmembrane helices predicted for PMI0105 by TMHMM2.0 at aa 86-108, 118-140, 160-182, 187-206, 213-235, 240-262, 289-311, 315-332 and 344-361 529507000600 PS00943 UbiA prenyltransferase family signature. 529507000601 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507000602 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 529507000603 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 529507000604 Subunit I/III interface [polypeptide binding]; other site 529507000605 Subunit III/IV interface [polypeptide binding]; other site 529507000606 HMMPfam hit to PF00510, Cytochrome c oxidase subunit III, score 8.8e-06 529507000607 5 probable transmembrane helices predicted for PMI0106 by TMHMM2.0 at aa 25-47, 62-84, 97-116, 136-158 and 179-201 529507000608 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 529507000609 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 529507000610 D-pathway; other site 529507000611 Putative ubiquinol binding site [chemical binding]; other site 529507000612 Low-spin heme (heme b) binding site [chemical binding]; other site 529507000613 Putative water exit pathway; other site 529507000614 Binuclear center (heme o3/CuB) [ion binding]; other site 529507000615 K-pathway; other site 529507000616 Putative proton exit pathway; other site 529507000617 14 probable transmembrane helices predicted for PMI0107 by TMHMM2.0 at aa 24-46, 65-87, 113-135, 148-170, 199-221, 241-263, 283-305, 318-340, 355-377, 390-412, 422-444, 465-487, 502-524 and 598-620 529507000618 HMMPfam hit to PF00115, Cytochrome C and Quinol oxidase polypeptide, score 2.5e-256 529507000619 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507000620 PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 529507000621 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 529507000622 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 529507000623 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 529507000624 HMMPfam hit to PF06481, COX Aromatic Rich Motif, score 8.5e-14 529507000625 HMMPfam hit to PF00116, Cytochrome C oxidase subunit II, periplasmic, score 1.1e-06 529507000626 3 probable transmembrane helices predicted for PMI0108 by TMHMM2.0 at aa 13-34, 49-71 and 92-112 529507000627 Signal peptide predicted for PMI0108 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.756 between residues 32 and 33 529507000628 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507000629 hypothetical protein; Provisional; Region: PRK11528 529507000630 HMMPfam hit to PF07135, Protein of unknown function (DUF1384), score 1.1e-145 529507000631 Signal peptide predicted for PMI0109 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.997 between residues 20 and 21 529507000632 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 529507000633 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 529507000634 ATP binding site [chemical binding]; other site 529507000635 Mg++ binding site [ion binding]; other site 529507000636 motif III; other site 529507000637 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 529507000638 nucleotide binding region [chemical binding]; other site 529507000639 ATP-binding site [chemical binding]; other site 529507000640 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 529507000641 putative RNA binding site [nucleotide binding]; other site 529507000642 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 2.4e-69 529507000643 PS00017 ATP/GTP-binding site motif A (P-loop). 529507000644 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 529507000645 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 2.1e-32 529507000646 HMMPfam hit to PF03880, DbpA RNA binding domain, score 2.5e-31 529507000647 muropeptide transporter; Reviewed; Region: ampG; PRK11902 529507000648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507000649 putative substrate translocation pore; other site 529507000650 14 probable transmembrane helices predicted for PMI0111 by TMHMM2.0 at aa 13-35, 50-69, 82-101, 106-123, 144-166, 176-193, 228-250, 260-282, 287-309, 319-341, 354-376, 380-402, 427-449 and 479-501 529507000651 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.9e-28 529507000652 Signal peptide predicted for PMI0111 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.563 between residues 32 and 33 529507000653 hypothetical protein; Provisional; Region: PRK11627 529507000654 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 529507000655 HMMPfam hit to PF03923, Uncharacterized lipoprotein, score 1.2e-05 529507000656 BolA-like protein; Region: BolA; cl00386 529507000657 HMMPfam hit to PF01722, BolA-like protein, score 5.2e-33 529507000658 trigger factor; Provisional; Region: tig; PRK01490 529507000659 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 529507000660 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 529507000661 HMMPfam hit to PF05697, Bacterial trigger factor protein (TF), score 5.7e-75 529507000662 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomera, score 2.3e-27 529507000663 HMMPfam hit to PF05698, Bacterial trigger factor protein (TF) C-ter, score 2e-55 529507000664 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 529507000665 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 529507000666 oligomer interface [polypeptide binding]; other site 529507000667 active site residues [active] 529507000668 HMMPfam hit to PF00574, Clp protease, score 3.5e-140 529507000669 PS00381 Endopeptidase Clp serine active site. 529507000670 PS00382 Endopeptidase Clp histidine active site. 529507000671 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 529507000672 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 529507000673 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 529507000674 Walker A motif; other site 529507000675 ATP binding site [chemical binding]; other site 529507000676 Walker B motif; other site 529507000677 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 529507000678 HMMPfam hit to PF06689, ClpX C4-type zinc finger, score 6.6e-26 529507000679 HMMPfam hit to PF07724, ATPase family associated with various cell, score 2.3e-79 529507000680 HMMPfam hit to PF00004, ATPase family associated with various cell, score 5.2e-23 529507000681 PS00017 ATP/GTP-binding site motif A (P-loop). 529507000682 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 529507000683 Found in ATP-dependent protease La (LON); Region: LON; smart00464 529507000684 Found in ATP-dependent protease La (LON); Region: LON; smart00464 529507000685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 529507000686 Walker A motif; other site 529507000687 ATP binding site [chemical binding]; other site 529507000688 Walker B motif; other site 529507000689 arginine finger; other site 529507000690 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 529507000691 HMMPfam hit to PF02190, ATP-dependent protease La (LON) domain, score 1.9e-71 529507000692 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 3.4e-43 529507000693 PS00017 ATP/GTP-binding site motif A (P-loop). 529507000694 HMMPfam hit to PF05362, Lon protease (S16) C-terminal proteolytic do, score 5.7e-151 529507000695 PS01046 ATP-dependent serine proteases, lon family, serine active site. 529507000696 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 529507000697 IHF dimer interface [polypeptide binding]; other site 529507000698 IHF - DNA interface [nucleotide binding]; other site 529507000699 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 5.7e-50 529507000700 PS00045 Bacterial histone-like DNA-binding proteins signature. 529507000701 periplasmic folding chaperone; Provisional; Region: PRK10788 529507000702 SurA N-terminal domain; Region: SurA_N_3; cl07813 529507000703 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 529507000704 Signal peptide predicted for PMI0119 by SignalP 2.0 HMM (Signal peptide probability 0.939) with cleavage site probability 0.556 between residues 42 and 43 529507000705 1 probable transmembrane helix predicted for PMI0119 by TMHMM2.0 at aa 13-35 529507000706 HMMPfam hit to PF00639, PPIC-type PPIASE domain, score 1.3e-11 529507000707 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 529507000708 Helix-hairpin-helix motif; Region: HHH; pfam00633 529507000709 Signal peptide predicted for PMI0120 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 30 and 31 529507000710 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 5.4e-06 529507000711 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 529507000712 active site 529507000713 HMMPfam hit to PF03061, Thioesterase superfamily, score 4.2e-12 529507000714 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 529507000715 Ligand Binding Site [chemical binding]; other site 529507000716 PS00190 Cytochrome c family heme-binding site signature. 529507000717 HMMPfam hit to PF06508, ExsB, score 2.1e-42 529507000718 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 529507000719 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 529507000720 putative DNA binding site [nucleotide binding]; other site 529507000721 putative Zn2+ binding site [ion binding]; other site 529507000722 AsnC family; Region: AsnC_trans_reg; pfam01037 529507000723 HMMPfam hit to PF01037, AsnC family, score 4.5e-47 529507000724 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 529507000725 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 529507000726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507000727 Walker A/P-loop; other site 529507000728 ATP binding site [chemical binding]; other site 529507000729 Q-loop/lid; other site 529507000730 ABC transporter signature motif; other site 529507000731 Walker B; other site 529507000732 D-loop; other site 529507000733 H-loop/switch region; other site 529507000734 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 5.3e-57 529507000735 6 probable transmembrane helices predicted for PMI0124 by TMHMM2.0 at aa 21-43, 58-77, 129-151, 156-175, 242-264 and 279-301 529507000736 HMMPfam hit to PF00005, ABC transporter, score 9.4e-50 529507000737 PS00017 ATP/GTP-binding site motif A (P-loop). 529507000738 PS00211 ABC transporters family signature. 529507000739 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 529507000740 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 529507000741 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 529507000742 Walker A/P-loop; other site 529507000743 ATP binding site [chemical binding]; other site 529507000744 Q-loop/lid; other site 529507000745 ABC transporter signature motif; other site 529507000746 Walker B; other site 529507000747 D-loop; other site 529507000748 H-loop/switch region; other site 529507000749 Signal peptide predicted for PMI0125 by SignalP 2.0 HMM (Signal peptide probability 0.910) with cleavage site probability 0.809 between residues 43 and 44 529507000750 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 8.7e-30 529507000751 6 probable transmembrane helices predicted for PMI0125 by TMHMM2.0 at aa 33-55, 70-89, 143-165, 170-189, 254-276 and 280-299 529507000752 HMMPfam hit to PF00005, ABC transporter, score 9.4e-53 529507000753 PS00017 ATP/GTP-binding site motif A (P-loop). 529507000754 PS00211 ABC transporters family signature. 529507000755 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 529507000756 Nitrogen regulatory protein P-II; Region: P-II; smart00938 529507000757 HMMPfam hit to PF00543, Nitrogen regulatory protein P-II, score 1.6e-63 529507000758 PS00496 P-II protein urydylation site. 529507000759 PS00638 P-II protein C-terminal region signature. 529507000760 ammonium transporter; Provisional; Region: PRK10666 529507000761 Signal peptide predicted for PMI0127 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.966 between residues 24 and 25 529507000762 12 probable transmembrane helices predicted for PMI0127 by TMHMM2.0 at aa 5-24, 39-61, 73-95, 123-145, 150-172, 187-209, 222-241, 251-273, 285-302, 306-328, 341-363 and 378-400 529507000763 HMMPfam hit to PF00909, Ammonium Transporter Family, score 2.8e-164 529507000764 PS01219 Ammonium transporters signature. 529507000765 acyl-CoA thioesterase II; Provisional; Region: PRK10526 529507000766 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 529507000767 active site 529507000768 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 529507000769 catalytic triad [active] 529507000770 dimer interface [polypeptide binding]; other site 529507000771 HMMPfam hit to PF02551, Acyl-CoA thioesterase, score 2.1e-53 529507000772 HMMPfam hit to PF02551, Acyl-CoA thioesterase, score 1.7e-39 529507000773 gene expression modulator; Provisional; Region: PRK10945 529507000774 HMMPfam hit to PF05321, Haemolysin expression modulating protein, score 4.9e-36 529507000775 Hha toxicity attenuator; Provisional; Region: PRK10667 529507000776 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 529507000777 Protein export membrane protein; Region: SecD_SecF; cl14618 529507000778 Protein export membrane protein; Region: SecD_SecF; cl14618 529507000779 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 529507000780 11 probable transmembrane helices predicted for PMI0131 by TMHMM2.0 at aa 10-32, 337-359, 369-391, 438-460, 470-492, 541-563, 608-630, 875-894, 898-920, 977-999 and 1009-1031 529507000781 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 529507000782 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 529507000783 HlyD family secretion protein; Region: HlyD_3; pfam13437 529507000784 HMMPfam hit to PF00529, HlyD family secretion protein, score 3.3e-74 529507000785 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507000786 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 529507000787 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 529507000788 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 529507000789 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 8e-21 529507000790 PS01081 Bacterial regulatory proteins, tetR family signature. 529507000791 Predicted helix-turn-helix motif with score 2108.000, SD 6.37 at aa 32-53, sequence TSLSDIATEAGVTRGAIYWHFK 529507000792 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 529507000793 HMMPfam hit to PF02635, DsrE/DsrF-like family, score 1.2e-34 529507000794 hypothetical protein; Provisional; Region: PRK11281 529507000795 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 529507000796 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 529507000797 Mechanosensitive ion channel; Region: MS_channel; pfam00924 529507000798 Signal peptide predicted for PMI0135 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.983 between residues 43 and 44 529507000799 12 probable transmembrane helices predicted for PMI0135 by TMHMM2.0 at aa 12-34, 527-544, 573-595, 605-624, 651-669, 679-701, 714-736, 746-768, 823-845, 865-887, 908-930 and 945-967 529507000800 PS00018 EF-hand calcium-binding domain. 529507000801 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 8.2e-78 529507000802 PS01246 Uncharacterized protein family UPF0003 signature. 529507000803 hypothetical protein; Provisional; Region: PRK11038 529507000804 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 529507000805 HMMPfam hit to PF07445, Primosomal replication protein priB and pri, score 1.6e-56 529507000806 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 529507000807 active site 529507000808 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 3e-46 529507000809 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 529507000810 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 529507000811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 529507000812 Walker A motif; other site 529507000813 ATP binding site [chemical binding]; other site 529507000814 Walker B motif; other site 529507000815 arginine finger; other site 529507000816 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 529507000817 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 529507000818 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 529507000819 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 1.2e-10 529507000820 PS00017 ATP/GTP-binding site motif A (P-loop). 529507000821 PS00215 Mitochondrial energy transfer proteins signature. 529507000822 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 529507000823 hypothetical protein; Validated; Region: PRK00153 529507000824 HMMPfam hit to PF02575, Uncharacterised BCR, YbaB family COG0718, score 5.2e-53 529507000825 recombination protein RecR; Reviewed; Region: recR; PRK00076 529507000826 RecR protein; Region: RecR; pfam02132 529507000827 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 529507000828 putative active site [active] 529507000829 putative metal-binding site [ion binding]; other site 529507000830 tetramer interface [polypeptide binding]; other site 529507000831 HMMPfam hit to PF02132, RecR protein, score 1.4e-17 529507000832 PS01300 RecR protein signature. 529507000833 HMMPfam hit to PF01751, Toprim domain, score 2.3e-19 529507000834 carbon starvation protein A; Provisional; Region: PRK15015 529507000835 Carbon starvation protein CstA; Region: CstA; pfam02554 529507000836 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 529507000837 Signal peptide predicted for PMI0142 by SignalP 2.0 HMM (Signal peptide probability 0.948) with cleavage site probability 0.744 between residues 27 and 28 529507000838 16 probable transmembrane helices predicted for PMI0142 by TMHMM2.0 at aa 12-29, 34-56, 89-111, 121-140, 161-183, 193-215, 220-242, 257-279, 286-305, 325-347, 364-386, 486-505, 532-551, 566-588, 595-617 and 663-685 529507000839 HMMPfam hit to PF02554, Carbon starvation protein CstA, score 8.6e-278 529507000840 Uncharacterized small protein [Function unknown]; Region: COG2879 529507000841 HMMPfam hit to PF04328, Protein of unknown function (DUF466), score 4.5e-43 529507000842 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 529507000843 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 529507000844 P-loop, Walker A motif; other site 529507000845 Base recognition motif; other site 529507000846 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 529507000847 HMMPfam hit to PF02492, CobW/HypB/UreG, nucleotide-binding domain, score 2.5e-68 529507000848 PS00017 ATP/GTP-binding site motif A (P-loop). 529507000849 HMMPfam hit to PF07683, Cobalamin synthesis protein cobW C-terminal, score 2.2e-35 529507000850 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 529507000851 HMMPfam hit to PF06354, Protein of unknown function (DUF1063), score 1.6e-215 529507000852 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 529507000853 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 529507000854 HMMPfam hit to PF03606, C4-dicarboxylate anaerobic carrier, score 2.3e-90 529507000855 11 probable transmembrane helices predicted for PMI0146 by TMHMM2.0 at aa 4-19, 26-48, 79-101, 114-136, 151-173, 194-216, 244-266, 273-292, 312-334, 346-368 and 435-454 529507000856 peptidase T; Region: peptidase-T; TIGR01882 529507000857 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 529507000858 metal binding site [ion binding]; metal-binding site 529507000859 dimer interface [polypeptide binding]; other site 529507000860 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 2.4e-10 529507000861 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 529507000862 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 529507000863 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 529507000864 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 529507000865 10 probable transmembrane helices predicted for PMI0149 by TMHMM2.0 at aa 12-34, 56-78, 91-113, 128-150, 162-184, 194-216, 237-259, 274-296, 317-334 and 384-406 529507000866 HMMPfam hit to PF01554, MatE, score 5.7e-29 529507000867 PS00267 Tachykinin family signature. 529507000868 HMMPfam hit to PF01554, MatE, score 1.5e-31 529507000869 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 529507000870 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 529507000871 HMMPfam hit to PF01408, Oxidoreductase family, NAD-binding Rossm, score 1.3e-05 529507000872 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 529507000873 hypothetical protein; Provisional; Region: PRK02399 529507000874 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 529507000875 HMMPfam hit to PF06792, Uncharacterised protein family (UPF0261), score 7e-226 529507000876 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 529507000877 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 529507000878 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 529507000879 DNA-binding interface [nucleotide binding]; DNA binding site 529507000880 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 3.5e-09 529507000881 Predicted helix-turn-helix motif with score 1737.000, SD 5.10 at aa 36-57, sequence PTVSELAAHAGVSRATAYRYFP 529507000882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 529507000883 YheO-like PAS domain; Region: PAS_6; pfam08348 529507000884 HTH domain; Region: HTH_22; pfam13309 529507000885 Predicted helix-turn-helix motif with score 1438.000, SD 4.08 at aa 188-209, sequence KAMEITAQYLGVSRATVYNDLK 529507000886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 529507000887 Coenzyme A binding pocket [chemical binding]; other site 529507000888 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.1e-17 529507000889 PS00213 Lipocalin signature. 529507000890 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 529507000891 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 529507000892 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 529507000893 Signal peptide predicted for PMI0157 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.654 between residues 28 and 29 529507000894 9 probable transmembrane helices predicted for PMI0157 by TMHMM2.0 at aa 10-41, 53-75, 80-102, 139-158, 173-195, 200-219, 232-254, 261-283 and 320-337 529507000895 HMMPfam hit to PF05145, ammonia monooxygenase, score 2.6e-31 529507000896 Signal peptide predicted for PMI0158 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.828 between residues 36 and 37 529507000897 multicopper oxidase; Provisional; Region: PRK10965 529507000898 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 529507000899 Multicopper oxidase; Region: Cu-oxidase; pfam00394 529507000900 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 529507000901 Signal peptide predicted for PMI0159 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.971 between residues 28 and 29 529507000902 HMMPfam hit to PF07732, Multicopper oxidase, score 1.7e-41 529507000903 PS00017 ATP/GTP-binding site motif A (P-loop). 529507000904 HMMPfam hit to PF07731, Multicopper oxidase, score 3.7e-17 529507000905 PS00080 Multicopper oxidases signature 2. 529507000906 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 529507000907 active site 529507000908 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 1.6e-37 529507000909 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 529507000910 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 529507000911 active site clefts [active] 529507000912 zinc binding site [ion binding]; other site 529507000913 dimer interface [polypeptide binding]; other site 529507000914 HMMPfam hit to PF00484, Carbonic anhydrase, score 1.6e-60 529507000915 PS00705 Prokaryotic-type carbonic anhydrases signature 2. 529507000916 PS00704 Prokaryotic-type carbonic anhydrases signature 1. 529507000917 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 529507000918 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 529507000919 Walker A/P-loop; other site 529507000920 ATP binding site [chemical binding]; other site 529507000921 Q-loop/lid; other site 529507000922 ABC transporter signature motif; other site 529507000923 Walker B; other site 529507000924 D-loop; other site 529507000925 H-loop/switch region; other site 529507000926 HMMPfam hit to PF00005, ABC transporter, score 6.7e-50 529507000927 PS00017 ATP/GTP-binding site motif A (P-loop). 529507000928 PS00211 ABC transporters family signature. 529507000929 inner membrane transport permease; Provisional; Region: PRK15066 529507000930 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 529507000931 HMMPfam hit to PF01061, ABC-2 type transporter, score 2.8e-46 529507000932 6 probable transmembrane helices predicted for PMI0163 by TMHMM2.0 at aa 20-42, 62-84, 104-126, 141-163, 176-198 and 226-248 529507000933 PS00890 ABC-2 type transport system integral membrane proteins signature. 529507000934 benzoate transport; Region: 2A0115; TIGR00895 529507000935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507000936 putative substrate translocation pore; other site 529507000937 HMMPfam hit to PF00083, Sugar (and other) transporter, score 5.1e-29 529507000938 12 probable transmembrane helices predicted for PMI0164 by TMHMM2.0 at aa 25-47, 57-79, 91-110, 115-137, 150-172, 177-194, 233-255, 265-287, 294-313, 318-340, 353-375 and 385-404 529507000939 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 7.4e-50 529507000940 HMMPfam hit to PF06779, Protein of unknown function (DUF1228), score 0.00043 529507000941 PS00217 Sugar transport proteins signature 2. 529507000942 PS00216 Sugar transport proteins signature 1. 529507000943 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 529507000944 heat shock protein HtpX; Provisional; Region: PRK02870 529507000945 HMMPfam hit to PF01435, Peptidase family M48, score 9.6e-30 529507000946 4 probable transmembrane helices predicted for PMI0166 by TMHMM2.0 at aa 16-38, 53-75, 182-204 and 219-241 529507000947 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 529507000948 Signal peptide predicted for PMI0166 by SignalP 2.0 HMM (Signal peptide probability 0.841) with cleavage site probability 0.343 between residues 34 and 35 529507000949 LemA family; Region: LemA; cl00742 529507000950 HMMPfam hit to PF04011, LemA family, score 5.9e-19 529507000951 2 probable transmembrane helices predicted for PMI0167 by TMHMM2.0 at aa 4-21 and 142-164 529507000952 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 529507000953 8 probable transmembrane helices predicted for PMI0168 by TMHMM2.0 at aa 5-27, 47-66, 81-103, 116-138, 148-170, 183-202, 212-231 and 238-260 529507000954 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 529507000955 4Fe-4S binding domain; Region: Fer4; cl02805 529507000956 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 4.5e-07 529507000957 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507000958 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507000959 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.0026 529507000960 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 529507000961 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 529507000962 molybdopterin cofactor binding site; other site 529507000963 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 529507000964 molybdopterin cofactor binding site; other site 529507000965 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 1.4e-18 529507000966 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 2.2e-62 529507000967 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 529507000968 Predicted helix-turn-helix motif with score 1249.000, SD 3.44 at aa 363-384, sequence WTIEKTSKETDIPQETIIRLAR 529507000969 Signal peptide predicted for PMI0170 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.562 between residues 32 and 33 529507000970 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 529507000971 Transcriptional regulator [Transcription]; Region: IclR; COG1414 529507000972 Bacterial transcriptional regulator; Region: IclR; pfam01614 529507000973 Predicted helix-turn-helix motif with score 1127.000, SD 3.03 at aa 27-48, sequence ARSSEIAKACSLSKSRLHKYLV 529507000974 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 529507000975 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 529507000976 HMMPfam hit to PF04261, Dyp-type peroxidase family, score 4.4e-125 529507000977 Signal peptide predicted for PMI0172 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 39 and 40 529507000978 Imelysin; Region: Peptidase_M75; cl09159 529507000979 Signal peptide predicted for PMI0173 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.957 between residues 27 and 28 529507000980 Iron permease FTR1 family; Region: FTR1; cl00475 529507000981 HMMPfam hit to PF03239, Iron permease FTR1 family, score 1.1e-14 529507000982 7 probable transmembrane helices predicted for PMI0174 by TMHMM2.0 at aa 4-26, 38-60, 70-92, 113-135, 150-172, 177-199 and 251-270 529507000983 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 529507000984 Signal peptide predicted for PMI0175 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.884 between residues 36 and 37 529507000985 Fe2+ transport protein; Region: Iron_transport; pfam10634 529507000986 Signal peptide predicted for PMI0176 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 21 and 22 529507000987 transposase (fragment) 529507000988 Predicted helix-turn-helix motif with score 1067.000, SD 2.82 at aa 1-22, sequence MKEEDICRENGISNACYYNWKS 529507000989 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 529507000990 HMMPfam hit to PF05638, Protein of unknown function (DUF796), score 5.6e-12 529507000991 2 probable transmembrane helices predicted for PMI0179 by TMHMM2.0 at aa 5-27 and 32-54 529507000992 Signal peptide predicted for PMI0179 by SignalP 2.0 HMM (Signal peptide probability 0.665) with cleavage site probability 0.510 between residues 34 and 35 529507000993 2 probable transmembrane helices predicted for PMI0180 by TMHMM2.0 at aa 38-60 and 80-102 529507000994 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 529507000995 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507000996 non-specific DNA binding site [nucleotide binding]; other site 529507000997 salt bridge; other site 529507000998 sequence-specific DNA binding site [nucleotide binding]; other site 529507000999 HMMPfam hit to PF01381, Helix-turn-helix, score 5.6e-13 529507001000 Predicted helix-turn-helix motif with score 2045.000, SD 6.15 at aa 32-53, sequence LSAKAVAERVGVSQQQFSRYEN 529507001001 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 529507001002 CHAP domain; Region: CHAP; pfam05257 529507001003 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 529507001004 HMMPfam hit to PF05257, CHAP domain, score 1.1e-26 529507001005 1 probable transmembrane helix predicted for PMI0183 by TMHMM2.0 at aa 66-85 529507001006 HMMPfam hit to PF03738, Glutathionylspermidine synthase, score 2.3e-15 529507001007 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 529507001008 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507001009 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 529507001010 dimerization interface [polypeptide binding]; other site 529507001011 substrate binding pocket [chemical binding]; other site 529507001012 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.8e-24 529507001013 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.6e-19 529507001014 PS00044 Bacterial regulatory proteins, lysR family signature. 529507001015 Predicted helix-turn-helix motif with score 1632.000, SD 4.75 at aa 32-53, sequence LSFALAAEELSLTPSAISHRIN 529507001016 permease DsdX; Provisional; Region: PRK09921 529507001017 gluconate transporter; Region: gntP; TIGR00791 529507001018 Signal peptide predicted for PMI0186 by SignalP 2.0 HMM (Signal peptide probability 0.709) with cleavage site probability 0.648 between residues 45 and 46 529507001019 12 probable transmembrane helices predicted for PMI0186 by TMHMM2.0 at aa 5-23, 27-44, 57-76, 104-126, 139-161, 176-198, 225-244, 259-281, 301-323, 343-365, 385-407 and 422-444 529507001020 HMMPfam hit to PF02447, GntP family permease, score 2e-215 529507001021 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 529507001022 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 529507001023 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 529507001024 catalytic residue [active] 529507001025 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 1.9e-47 529507001026 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 529507001027 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 529507001028 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 529507001029 Walker A/P-loop; other site 529507001030 ATP binding site [chemical binding]; other site 529507001031 Q-loop/lid; other site 529507001032 ABC transporter signature motif; other site 529507001033 Walker B; other site 529507001034 D-loop; other site 529507001035 H-loop/switch region; other site 529507001036 TOBE domain; Region: TOBE_2; pfam08402 529507001037 HMMPfam hit to PF00005, ABC transporter, score 3e-70 529507001038 PS00211 ABC transporters family signature. 529507001039 PS00017 ATP/GTP-binding site motif A (P-loop). 529507001040 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 529507001041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507001042 dimer interface [polypeptide binding]; other site 529507001043 conserved gate region; other site 529507001044 putative PBP binding loops; other site 529507001045 ABC-ATPase subunit interface; other site 529507001046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507001047 dimer interface [polypeptide binding]; other site 529507001048 conserved gate region; other site 529507001049 putative PBP binding loops; other site 529507001050 ABC-ATPase subunit interface; other site 529507001051 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 7.8e-08 529507001052 15 probable transmembrane helices predicted for PMI0189 by TMHMM2.0 at aa 23-42, 57-79, 91-113, 118-137, 149-171, 204-226, 239-261, 281-303, 330-352, 387-409, 430-452, 496-518, 530-552, 619-641 and 662-684 529507001053 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.2e-07 529507001054 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507001055 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 529507001056 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 529507001057 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 7.5e-12 529507001058 Signal peptide predicted for PMI0190 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.892 between residues 25 and 26 529507001059 regulatory protein UhpC; Provisional; Region: PRK11663 529507001060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507001061 putative substrate translocation pore; other site 529507001062 12 probable transmembrane helices predicted for PMI0191 by TMHMM2.0 at aa 19-41, 56-78, 85-107, 111-133, 145-167, 172-191, 235-257, 277-299, 311-330, 334-356, 368-390 and 400-422 529507001063 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.8e-54 529507001064 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 529507001065 MASE1; Region: MASE1; pfam05231 529507001066 Histidine kinase; Region: HisKA_3; pfam07730 529507001067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 529507001068 ATP binding site [chemical binding]; other site 529507001069 Mg2+ binding site [ion binding]; other site 529507001070 G-X-G motif; other site 529507001071 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 4.7e-14 529507001072 HMMPfam hit to PF07730, Histidine kinase, score 7.9e-16 529507001073 Predicted helix-turn-helix motif with score 1029.000, SD 2.69 at aa 355-376, sequence EQIERLAQQIHQSTRQLLRQLR 529507001074 HMMPfam hit to PF05231, MASE1, score 2.2e-52 529507001075 7 probable transmembrane helices predicted for PMI0192 by TMHMM2.0 at aa 7-29, 39-61, 82-104, 114-136, 143-165, 185-204 and 211-233 529507001076 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 529507001077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507001078 active site 529507001079 phosphorylation site [posttranslational modification] 529507001080 intermolecular recognition site; other site 529507001081 dimerization interface [polypeptide binding]; other site 529507001082 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 529507001083 DNA binding residues [nucleotide binding] 529507001084 dimerization interface [polypeptide binding]; other site 529507001085 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 3.4e-22 529507001086 PS00622 Bacterial regulatory proteins, luxR family signature. 529507001087 Predicted helix-turn-helix motif with score 1056.000, SD 2.78 at aa 161-182, sequence INVKAIAVQLNLSHKTVHVHRA 529507001088 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.4e-37 529507001089 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 529507001090 tetramerization interface [polypeptide binding]; other site 529507001091 active site 529507001092 HMMPfam hit to PF02261, Aspartate decarboxylase, score 1.6e-82 529507001093 Pantoate-beta-alanine ligase; Region: PanC; cd00560 529507001094 pantoate--beta-alanine ligase; Region: panC; TIGR00018 529507001095 active site 529507001096 ATP-binding site [chemical binding]; other site 529507001097 pantoate-binding site; other site 529507001098 HXXH motif; other site 529507001099 HMMPfam hit to PF02569, Pantoate-beta-alanine ligase, score 8.1e-137 529507001100 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 529507001101 oligomerization interface [polypeptide binding]; other site 529507001102 active site 529507001103 metal binding site [ion binding]; metal-binding site 529507001104 HMMPfam hit to PF02548, Ketopantoate hydroxymethyltransferase, score 4.9e-151 529507001105 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 529507001106 catalytic center binding site [active] 529507001107 ATP binding site [chemical binding]; other site 529507001108 HMMPfam hit to PF01288, 7,8-dihydro-6-hydroxymethylpterin-pyrophosph, score 8.8e-64 529507001109 PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. 529507001110 poly(A) polymerase; Region: pcnB; TIGR01942 529507001111 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 529507001112 active site 529507001113 NTP binding site [chemical binding]; other site 529507001114 metal binding triad [ion binding]; metal-binding site 529507001115 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 529507001116 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 529507001117 HMMPfam hit to PF01743, Poly A polymerase family, score 1.2e-67 529507001118 Signal peptide predicted for PMI0199 by SignalP 2.0 HMM (Signal peptide probability 0.746) with cleavage site probability 0.742 between residues 31 and 32 529507001119 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 529507001120 HMMPfam hit to PF01258, Prokaryotic dksA/traR C4-type zinc finge, score 4.6e-35 529507001121 PS01102 Prokaryotic dksA/traR C4-type zinc finger. 529507001122 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 529507001123 HMMPfam hit to PF03749, Sugar fermentation stimulation protein, score 6.2e-107 529507001124 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507001125 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 529507001126 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 529507001127 ATP binding site [chemical binding]; other site 529507001128 putative Mg++ binding site [ion binding]; other site 529507001129 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 529507001130 nucleotide binding region [chemical binding]; other site 529507001131 ATP-binding site [chemical binding]; other site 529507001132 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 529507001133 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 529507001134 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 2.6e-11 529507001135 PS00017 ATP/GTP-binding site motif A (P-loop). 529507001136 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 3.9e-11 529507001137 HMMPfam hit to PF04408, Helicase associated domain (HA2), score 0.00039 529507001138 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 529507001139 Transglycosylase; Region: Transgly; pfam00912 529507001140 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 529507001141 Signal peptide predicted for PMI0204 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.925 between residues 41 and 42 529507001142 1 probable transmembrane helix predicted for PMI0204 by TMHMM2.0 at aa 17-39 529507001143 HMMPfam hit to PF00912, Transglycosylase, score 3.6e-82 529507001144 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 1.2e-20 529507001145 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 529507001146 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 529507001147 inhibitor-cofactor binding pocket; inhibition site 529507001148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507001149 catalytic residue [active] 529507001150 HMMPfam hit to PF00202, Aminotransferase class-III, score 9.3e-119 529507001151 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 529507001152 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 529507001153 HMMPfam hit to PF01521, HesB-like domain, score 1.6e-56 529507001154 PS01152 Hypothetical hesB/yadR/yfhF family signature. 529507001155 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 529507001156 HMMPfam hit to PF05638, Protein of unknown function (DUF796), score 1.3e-82 529507001157 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 529507001158 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 529507001159 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 529507001160 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 529507001161 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 529507001162 HMMPfam hit to PF04524, Protein of unknown function, DUF586, score 1.2e-43 529507001163 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 529507001164 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 529507001165 active site flap/lid [active] 529507001166 nucleophilic elbow; other site 529507001167 catalytic triad [active] 529507001168 HMMPfam hit to PF01764, Lipase (class 3), score 4.7e-25 529507001169 Signal peptide predicted for PMI0211 by SignalP 2.0 HMM (Signal peptide probability 0.933) with cleavage site probability 0.596 between residues 28 and 29 529507001170 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507001171 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 529507001172 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 529507001173 cobalamin binding residues [chemical binding]; other site 529507001174 putative BtuC binding residues; other site 529507001175 dimer interface [polypeptide binding]; other site 529507001176 HMMPfam hit to PF01497, Periplasmic binding protein, score 2.2e-30 529507001177 1 probable transmembrane helix predicted for PMI0213 by TMHMM2.0 at aa 13-30 529507001178 Signal peptide predicted for PMI0213 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 29 and 30 529507001179 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 529507001180 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 529507001181 HMMPfam hit to PF01048, Phosphorylase family, score 1.4e-95 529507001182 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 529507001183 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 529507001184 Zn2+ binding site [ion binding]; other site 529507001185 Mg2+ binding site [ion binding]; other site 529507001186 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 529507001187 HMMPfam hit to PF01966, HD domain, score 0.00022 529507001188 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 529507001189 TRAM domain; Region: TRAM; pfam01938 529507001190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507001191 S-adenosylmethionine binding site [chemical binding]; other site 529507001192 HMMPfam hit to PF01938, TRAM domain, score 4e-10 529507001193 HMMPfam hit to PF05958, tRNA (Uracil-5-)-methyltransferase, score 1.1e-09 529507001194 PS01230 RNA methyltransferase trmA family signature 1. 529507001195 PS01231 RNA methyltransferase trmA family signature 2. 529507001196 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 529507001197 HD domain; Region: HD_4; pfam13328 529507001198 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 529507001199 synthetase active site [active] 529507001200 NTP binding site [chemical binding]; other site 529507001201 metal binding site [ion binding]; metal-binding site 529507001202 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 529507001203 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 529507001204 HMMPfam hit to PF04607, Region found in RelA / SpoT proteins, score 9.3e-49 529507001205 HMMPfam hit to PF02824, TGS domain, score 5.7e-32 529507001206 HMMPfam hit to PF01842, ACT domain, score 1e-13 529507001207 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 529507001208 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 529507001209 homodimer interface [polypeptide binding]; other site 529507001210 metal binding site [ion binding]; metal-binding site 529507001211 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 529507001212 homodimer interface [polypeptide binding]; other site 529507001213 active site 529507001214 putative chemical substrate binding site [chemical binding]; other site 529507001215 metal binding site [ion binding]; metal-binding site 529507001216 HMMPfam hit to PF03819, MazG nucleotide pyrophosphohydrolase domain, score 8.6e-42 529507001217 HMMPfam hit to PF03819, MazG nucleotide pyrophosphohydrolase domain, score 2.9e-06 529507001218 CTP synthetase; Validated; Region: pyrG; PRK05380 529507001219 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 529507001220 Catalytic site [active] 529507001221 active site 529507001222 UTP binding site [chemical binding]; other site 529507001223 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 529507001224 active site 529507001225 putative oxyanion hole; other site 529507001226 catalytic triad [active] 529507001227 Signal peptide predicted for PMI0220 by SignalP 2.0 HMM (Signal peptide probability 0.974) with cleavage site probability 0.942 between residues 26 and 27 529507001228 HMMPfam hit to PF06418, CTP synthase N-terminus, score 7.5e-216 529507001229 1 probable transmembrane helix predicted for PMI0220 by TMHMM2.0 at aa 7-29 529507001230 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 1.9e-76 529507001231 PS00442 Glutamine amidotransferases class-I active site. 529507001232 enolase; Provisional; Region: eno; PRK00077 529507001233 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 529507001234 dimer interface [polypeptide binding]; other site 529507001235 metal binding site [ion binding]; metal-binding site 529507001236 substrate binding pocket [chemical binding]; other site 529507001237 HMMPfam hit to PF03952, Enolase, N-terminal domain, score 2.9e-70 529507001238 HMMPfam hit to PF00113, Enolase, C-terminal TIM barrel domain, score 1.5e-180 529507001239 PS00164 Enolase signature. 529507001240 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 529507001241 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 529507001242 transmembrane helices; other site 529507001243 HMMPfam hit to PF00939, Sodium:sulfate symporter transmembrane, score 3.5e-15 529507001244 13 probable transmembrane helices predicted for PMI0222 by TMHMM2.0 at aa 20-39, 59-81, 94-113, 142-164, 176-198, 213-235, 264-286, 291-310, 317-339, 354-371, 378-400, 404-426 and 439-458 529507001245 PS01271 Sodium:sulfate symporter family signature. 529507001246 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 529507001247 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 529507001248 dimer interface [polypeptide binding]; other site 529507001249 PYR/PP interface [polypeptide binding]; other site 529507001250 TPP binding site [chemical binding]; other site 529507001251 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 529507001252 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 529507001253 TPP-binding site [chemical binding]; other site 529507001254 dimer interface [polypeptide binding]; other site 529507001255 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 1.3e-42 529507001256 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 0.00028 529507001257 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 529507001258 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 529507001259 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 529507001260 N-acetyl-D-glucosamine binding site [chemical binding]; other site 529507001261 catalytic residue [active] 529507001262 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 529507001263 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 529507001264 HMMPfam hit to PF01476, LysM domain, score 1.5e-09 529507001265 HMMPfam hit to PF01476, LysM domain, score 1.2e-16 529507001266 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 2.9e-33 529507001267 PS00922 Prokaryotic transglycosylases signature. 529507001268 HMMPfam hit to PF06474, MLTD_N, score 1.9e-10 529507001269 Signal peptide predicted for PMI0224 by SignalP 2.0 HMM (Signal peptide probability 0.974) with cleavage site probability 0.524 between residues 19 and 20 529507001270 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507001271 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 529507001272 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 4.6e-32 529507001273 PS00430 TonB-dependent receptor proteins signature 1. 529507001274 Methyltransferase domain; Region: Methyltransf_11; pfam08241 529507001275 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 529507001276 RNA/DNA hybrid binding site [nucleotide binding]; other site 529507001277 active site 529507001278 HMMPfam hit to PF00075, RNase H, score 5.7e-65 529507001279 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 529507001280 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 529507001281 active site 529507001282 catalytic site [active] 529507001283 substrate binding site [chemical binding]; other site 529507001284 HMMPfam hit to PF00929, Exonuclease, score 2.1e-48 529507001285 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 529507001286 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 529507001287 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 529507001288 ABC-ATPase subunit interface; other site 529507001289 dimer interface [polypeptide binding]; other site 529507001290 putative PBP binding regions; other site 529507001291 9 probable transmembrane helices predicted for PMI0229 by TMHMM2.0 at aa 31-53, 82-104, 116-138, 143-162, 175-197, 222-244, 269-291, 306-325 and 332-354 529507001292 HMMPfam hit to PF01032, FecCD transport family, score 4.6e-93 529507001293 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 529507001294 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 529507001295 Walker A/P-loop; other site 529507001296 ATP binding site [chemical binding]; other site 529507001297 Q-loop/lid; other site 529507001298 ABC transporter signature motif; other site 529507001299 Walker B; other site 529507001300 D-loop; other site 529507001301 H-loop/switch region; other site 529507001302 HMMPfam hit to PF00005, ABC transporter, score 1.6e-46 529507001303 PS00017 ATP/GTP-binding site motif A (P-loop). 529507001304 PS00211 ABC transporters family signature. 529507001305 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 529507001306 HMMPfam hit to PF03328, HpcH/HpaI aldolase/citrate lyase family, score 2.6e-13 529507001307 IucA / IucC family; Region: IucA_IucC; pfam04183 529507001308 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 529507001309 HMMPfam hit to PF04183, IucA / IucC family, score 1.2e-101 529507001310 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 529507001311 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 529507001312 N-terminal plug; other site 529507001313 ligand-binding site [chemical binding]; other site 529507001314 Signal peptide predicted for PMI0233 by SignalP 2.0 HMM (Signal peptide probability 0.966) with cleavage site probability 0.764 between residues 23 and 24 529507001315 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 4.5e-16 529507001316 HMMPfam hit to PF00593, TonB dependent receptor, score 1.5e-26 529507001317 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS01156 TonB-dependent receptor proteins signature 2. 529507001318 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 529507001319 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 529507001320 dimer interface [polypeptide binding]; other site 529507001321 active site 529507001322 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 529507001323 catalytic residues [active] 529507001324 substrate binding site [chemical binding]; other site 529507001325 HMMPfam hit to PF02784, Pyridoxal-dependent decarboxylase, pyri, score 7.1e-10 529507001326 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 529507001327 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 529507001328 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 529507001329 dimer interface [polypeptide binding]; other site 529507001330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507001331 catalytic residue [active] 529507001332 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 5.4e-68 529507001333 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 529507001334 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 529507001335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507001336 Major Facilitator Superfamily; Region: MFS_1; pfam07690 529507001337 putative substrate translocation pore; other site 529507001338 12 probable transmembrane helices predicted for PMI0237 by TMHMM2.0 at aa 7-26, 46-68, 81-103, 108-130, 137-159, 164-186, 211-233, 253-275, 282-304, 309-331, 343-365 and 369-391 529507001339 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 8.2e-36 529507001340 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 529507001341 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 529507001342 putative ligand binding residues [chemical binding]; other site 529507001343 Signal peptide predicted for PMI0238 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.942 between residues 19 and 20 529507001344 HMMPfam hit to PF01497, Periplasmic binding protein, score 3.9e-05 529507001345 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 529507001346 ParB-like nuclease domain; Region: ParBc; cl02129 529507001347 transketolase; Reviewed; Region: PRK12753 529507001348 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 529507001349 TPP-binding site [chemical binding]; other site 529507001350 dimer interface [polypeptide binding]; other site 529507001351 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 529507001352 PYR/PP interface [polypeptide binding]; other site 529507001353 dimer interface [polypeptide binding]; other site 529507001354 TPP binding site [chemical binding]; other site 529507001355 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 529507001356 HMMPfam hit to PF00456, Transketolase, thiamine diphosphate b, score 9.9e-244 529507001357 PS00801 Transketolase signature 1. 529507001358 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 1.7e-66 529507001359 PS00802 Transketolase signature 2. 529507001360 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 1.3e-13 529507001361 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 529507001362 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 529507001363 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 529507001364 HMMPfam hit to PF00044, Glyceraldehyde 3-phosphate dehydrogenase, NA, score 2e-74 529507001365 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 529507001366 HMMPfam hit to PF02800, Glyceraldehyde 3-phosphate dehydrogenase, C-, score 9.3e-73 529507001367 HMMPfam hit to PF00162, Phosphoglycerate kinase, score 1.1e-212 529507001368 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 529507001369 Phosphoglycerate kinase; Region: PGK; pfam00162 529507001370 substrate binding site [chemical binding]; other site 529507001371 hinge regions; other site 529507001372 ADP binding site [chemical binding]; other site 529507001373 catalytic site [active] 529507001374 PS00111 Phosphoglycerate kinase signature. 529507001375 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 529507001376 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 529507001377 active site 529507001378 intersubunit interface [polypeptide binding]; other site 529507001379 zinc binding site [ion binding]; other site 529507001380 Na+ binding site [ion binding]; other site 529507001381 HMMPfam hit to PF01116, Fructose-bisphosphate aldolase class-II, score 3.4e-204 529507001382 PS00602 Fructose-bisphosphate aldolase class-II signature 1. 529507001383 PS00806 Fructose-bisphosphate aldolase class-II signature 2. 529507001384 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 529507001385 2 probable transmembrane helices predicted for PMI0244 by TMHMM2.0 at aa 7-26 and 36-58 529507001386 HMMPfam hit to PF05154, TM2 domain, score 1.8e-16 529507001387 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 529507001388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507001389 putative substrate translocation pore; other site 529507001390 POT family; Region: PTR2; pfam00854 529507001391 14 probable transmembrane helices predicted for PMI0245 by TMHMM2.0 at aa 20-42, 52-74, 83-105, 109-131, 144-166, 171-193, 214-231, 235-257, 270-287, 315-337, 350-372, 387-409, 416-438 and 458-480 529507001392 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.3e-05 529507001393 HMMPfam hit to PF00854, POT family, score 5.2e-99 529507001394 PS01023 PTR2 family proton/oligopeptide symporters signature 2. 529507001395 PS01022 PTR2 family proton/oligopeptide symporters signature 1. 529507001396 Flavin Reductases; Region: FlaRed; cl00801 529507001397 HMMPfam hit to PF01613, Flavin reductase like domain, score 1.6e-54 529507001398 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 529507001399 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 529507001400 HMMPfam hit to PF01047, MarR family, score 4.2e-23 529507001401 BCCT family transporter; Region: BCCT; cl00569 529507001402 HMMPfam hit to PF02028, BCCT family transporter, score 2.1e-232 529507001403 12 probable transmembrane helices predicted for PMI0249 by TMHMM2.0 at aa 37-59, 74-93, 113-135, 168-190, 210-232, 252-271, 283-305, 336-358, 371-390, 422-444, 471-493 and 497-516 529507001404 PS01303 BCCT family of transporters signature. 529507001405 HMMPfam hit to PF05115, Cytochrome B6-F complex subunit VI (PetL), score 0.15 529507001406 Signal peptide predicted for PMI0249 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.975 between residues 59 and 60 529507001407 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 529507001408 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 529507001409 HMMPfam hit to PF02987, Late embryogenesis abundant protein, score 2.6e-05 529507001410 HMMPfam hit to PF02987, Late embryogenesis abundant protein, score 0.0004 529507001411 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507001412 Signal peptide predicted for PMI0250 by SignalP 2.0 HMM (Signal peptide probability 0.671) with cleavage site probability 0.639 between residues 36 and 37 529507001413 Predicted membrane protein [Function unknown]; Region: COG2323 529507001414 3 probable transmembrane helices predicted for PMI0251 by TMHMM2.0 at aa 4-26, 33-52 and 57-79 529507001415 HMMPfam hit to PF04239, Protein of unknown function (DUF421), score 6.4e-21 529507001416 ribonuclease Z; Region: RNase_Z; TIGR02651 529507001417 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 1e-09 529507001418 1 probable transmembrane helix predicted for PMI0253 by TMHMM2.0 at aa 10-27 529507001419 fimbrial operon 1 529507001420 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507001421 Signal peptide predicted for PMI0254 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24 529507001422 HMMPfam hit to PF00419, Fimbrial protein, score 3.5e-50 529507001423 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 529507001424 PapC N-terminal domain; Region: PapC_N; pfam13954 529507001425 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 529507001426 PapC C-terminal domain; Region: PapC_C; pfam13953 529507001427 Signal peptide predicted for PMI0255 by SignalP 2.0 HMM (Signal peptide probability 0.901) with cleavage site probability 0.595 between residues 44 and 45 529507001428 1 probable transmembrane helix predicted for PMI0255 by TMHMM2.0 at aa 23-45 529507001429 HMMPfam hit to PF00577, Fimbrial Usher protein, score 0 529507001430 fimbrial chaperone (pseudogene);This CDS appears to have an in-frame stop codon. 529507001431 Signal peptide predicted for PMI0256 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.538 between residues 26 and 27 529507001432 1 probable transmembrane helix predicted for PMI0256 by TMHMM2.0 at aa 7-29 529507001433 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 8.6e-47 529507001434 PS00635 Gram-negative pili assembly chaperone signature. 529507001435 Fimbrial protein; Region: Fimbrial; pfam00419 529507001436 Signal peptide predicted for PMI0257 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.973 between residues 27 and 28 529507001437 1 probable transmembrane helix predicted for PMI0257 by TMHMM2.0 at aa 9-31 529507001438 Fimbrial protein; Region: Fimbrial; cl01416 529507001439 Signal peptide predicted for PMI0258 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 21 and 22 529507001440 Signal peptide predicted for PMI0259 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.512 between residues 38 and 39 529507001441 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507001442 HMMPfam hit to PF00419, Fimbrial protein, score 1.1e-21 529507001443 PapG chaperone-binding domain; Region: PapG_C; pfam03628 529507001444 Signal peptide predicted for PMI0260 by SignalP 2.0 HMM (Signal peptide probability 0.980) with cleavage site probability 0.977 between residues 25 and 26 529507001445 1 probable transmembrane helix predicted for PMI0260 by TMHMM2.0 at aa 9-31 529507001446 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 529507001447 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507001448 non-specific DNA binding site [nucleotide binding]; other site 529507001449 salt bridge; other site 529507001450 sequence-specific DNA binding site [nucleotide binding]; other site 529507001451 HMMPfam hit to PF01381, Helix-turn-helix, score 2.9e-16 529507001452 Predicted helix-turn-helix motif with score 1977.000, SD 5.92 at aa 28-49, sequence YTGSQLAAKLGVSQQQFSRYER 529507001453 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 529507001454 Int/Topo IB signature motif; other site 529507001455 HMMPfam hit to PF00589, Phage integrase family, score 6.8e-44 529507001456 fimbrial operon 2 (MR/P fimbrial operon) 529507001457 Fimbrial protein; Region: Fimbrial; cl01416 529507001458 Signal peptide predicted for PMI0263 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24 529507001459 1 probable transmembrane helix predicted for PMI0263 by TMHMM2.0 at aa 35-53 529507001460 HMMPfam hit to PF00419, Fimbrial protein, score 1.2e-59 529507001461 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507001462 Signal peptide predicted for PMI0264 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.968 between residues 23 and 24 529507001463 HMMPfam hit to PF00419, Fimbrial protein, score 1.7e-13 529507001464 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 529507001465 PapC N-terminal domain; Region: PapC_N; pfam13954 529507001466 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 529507001467 PapC C-terminal domain; Region: PapC_C; pfam13953 529507001468 Signal peptide predicted for PMI0265 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.943 between residues 44 and 45 529507001469 1 probable transmembrane helix predicted for PMI0265 by TMHMM2.0 at aa 21-43 529507001470 HMMPfam hit to PF00577, Fimbrial Usher protein, score 0 529507001471 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 529507001472 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 529507001473 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 529507001474 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 529507001475 Signal peptide predicted for PMI0266 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.987 between residues 26 and 27 529507001476 1 probable transmembrane helix predicted for PMI0266 by TMHMM2.0 at aa 7-29 529507001477 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 3.8e-46 529507001478 PS00635 Gram-negative pili assembly chaperone signature. 529507001479 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 1.2e-09 529507001480 Fimbrial protein; Region: Fimbrial; pfam00419 529507001481 Signal peptide predicted for PMI0267 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.859 between residues 31 and 32 529507001482 1 probable transmembrane helix predicted for PMI0267 by TMHMM2.0 at aa 13-35 529507001483 HMMPfam hit to PF00419, Fimbrial protein, score 0.00019 529507001484 Fimbrial protein; Region: Fimbrial; cl01416 529507001485 Signal peptide predicted for PMI0268 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21 529507001486 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507001487 Signal peptide predicted for PMI0269 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 26 and 27 529507001488 1 probable transmembrane helix predicted for PMI0269 by TMHMM2.0 at aa 7-29 529507001489 HMMPfam hit to PF00419, Fimbrial protein, score 1e-17 529507001490 Signal peptide predicted for PMI0270 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 24 and 25 529507001491 1 probable transmembrane helix predicted for PMI0270 by TMHMM2.0 at aa 13-35 529507001492 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 529507001493 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507001494 non-specific DNA binding site [nucleotide binding]; other site 529507001495 salt bridge; other site 529507001496 sequence-specific DNA binding site [nucleotide binding]; other site 529507001497 HMMPfam hit to PF01381, Helix-turn-helix, score 3.4e-14 529507001498 Predicted helix-turn-helix motif with score 1835.000, SD 5.44 at aa 32-53, sequence YTGMQLAKKIGVSQQQFSRYER 529507001499 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 529507001500 AbgT putative transporter family; Region: ABG_transport; pfam03806 529507001501 HMMPfam hit to PF03806, AbgT transporter family, score 0 529507001502 11 probable transmembrane helices predicted for PMI0272 by TMHMM2.0 at aa 21-43, 92-114, 131-153, 218-235, 272-291, 311-333, 354-376, 391-413, 420-437, 447-469 and 490-512 529507001503 PS00019 Actinin-type actin-binding domain signature 1. 529507001504 hypothetical protein; Provisional; Region: PRK10203 529507001505 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 529507001506 HMMPfam hit to PF02627, Carboxymuconolactone decarboxylase family, score 1.3e-24 529507001507 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 529507001508 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 529507001509 HMMPfam hit to PF02366, Dolichyl-phosphate-mannose-protein mannosylt, score 3.2e-28 529507001510 12 probable transmembrane helices predicted for PMI0275 by TMHMM2.0 at aa 12-31, 84-103, 115-137, 141-158, 171-193, 208-230, 260-282, 292-309, 314-333, 348-370, 383-402 and 407-424 529507001511 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 529507001512 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.9e-58 529507001513 HMMPfam hit to PF02321, Outer membrane efflux protein, score 2.9e-44 529507001514 1 probable transmembrane helix predicted for PMI0276 by TMHMM2.0 at aa 7-29 529507001515 Signal peptide predicted for PMI0276 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 22 and 23 529507001516 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 529507001517 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 529507001518 HlyD family secretion protein; Region: HlyD_3; pfam13437 529507001519 PS00543 HlyD family secretion proteins signature. 529507001520 HMMPfam hit to PF00529, HlyD family secretion protein, score 2.3e-84 529507001521 1 probable transmembrane helix predicted for PMI0277 by TMHMM2.0 at aa 23-45 529507001522 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 529507001523 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 529507001524 Walker A/P-loop; other site 529507001525 ATP binding site [chemical binding]; other site 529507001526 Q-loop/lid; other site 529507001527 ABC transporter signature motif; other site 529507001528 Walker B; other site 529507001529 D-loop; other site 529507001530 H-loop/switch region; other site 529507001531 HMMPfam hit to PF00005, ABC transporter, score 6.2e-54 529507001532 PS00211 ABC transporters family signature. 529507001533 PS00017 ATP/GTP-binding site motif A (P-loop). 529507001534 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 0.015 529507001535 4 probable transmembrane helices predicted for PMI0278 by TMHMM2.0 at aa 22-44, 94-116, 122-144 and 221-243 529507001536 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 529507001537 active site 529507001538 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 529507001539 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.0034 529507001540 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 6.5e-05 529507001541 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.0043 529507001542 HMMPfam hit to PF00413, Matrixin, score 0.00032 529507001543 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 529507001544 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 529507001545 active site 529507001546 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 529507001547 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 529507001548 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.019 529507001549 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.059 529507001550 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.07 529507001551 PS00330 Hemolysin-type calcium-binding region signature. 529507001552 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 8.1e-05 529507001553 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.0012 529507001554 PS00330 Hemolysin-type calcium-binding region signature. 529507001555 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.0011 529507001556 PS00330 Hemolysin-type calcium-binding region signature. 529507001557 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.00056 529507001558 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.0087 529507001559 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 529507001560 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 529507001561 active site 529507001562 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 529507001563 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 4.2 529507001564 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.049 529507001565 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 4.7 529507001566 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 7.7e-06 529507001567 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.0016 529507001568 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.21 529507001569 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 529507001570 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 529507001571 active site 529507001572 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 529507001573 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 1.4 529507001574 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.049 529507001575 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 4.7 529507001576 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 7.7e-06 529507001577 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.0016 529507001578 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.21 529507001579 4 probable transmembrane helices predicted for PMI0284 by TMHMM2.0 at aa 20-42, 49-68, 72-94 and 115-137 529507001580 Domain of unknown function (DUF4200); Region: DUF4200; pfam13863 529507001581 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 529507001582 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 529507001583 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 529507001584 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 529507001585 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 1.4 529507001586 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.026 529507001587 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 4.7 529507001588 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 5.8e-06 529507001589 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.0016 529507001590 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.21 529507001591 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 529507001592 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 529507001593 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507001594 non-specific DNA binding site [nucleotide binding]; other site 529507001595 salt bridge; other site 529507001596 sequence-specific DNA binding site [nucleotide binding]; other site 529507001597 HMMPfam hit to PF01381, Helix-turn-helix, score 1.3e-11 529507001598 Predicted helix-turn-helix motif with score 1911.000, SD 5.70 at aa 27-48, sequence LKAEDVAESLGISRAAVYRLEK 529507001599 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 529507001600 allantoate amidohydrolase; Reviewed; Region: PRK09290 529507001601 active site 529507001602 metal binding site [ion binding]; metal-binding site 529507001603 dimer interface [polypeptide binding]; other site 529507001604 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 4.7e-29 529507001605 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 0.0036 529507001606 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 529507001607 Signal peptide predicted for PMI0288 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 22 and 23 529507001608 beta-phosphoglucomutase; Region: bPGM; TIGR01990 529507001609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 529507001610 motif II; other site 529507001611 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 4.3e-27 529507001612 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 529507001613 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 529507001614 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 529507001615 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 529507001616 HMMPfam hit to PF03632, Glycosyl hydrolase family, score 2.6e-140 529507001617 HMMPfam hit to PF03636, Glycosyl hydrolase family 65, N-termi, score 3.7e-37 529507001618 Predicted helix-turn-helix motif with score 1055.000, SD 2.78 at aa 241-262, sequence IHCTKFANMADMSHYAILYTFK 529507001619 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 529507001620 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 529507001621 active site turn [active] 529507001622 phosphorylation site [posttranslational modification] 529507001623 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 529507001624 10 probable transmembrane helices predicted for PMI0291 by TMHMM2.0 at aa 107-129, 149-171, 184-206, 226-245, 257-279, 304-326, 339-361, 371-393, 400-419 and 439-461 529507001625 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 5.9e-36 529507001626 HMMPfam hit to PF00367, phosphotransferase system, EIIB, score 1.2e-12 529507001627 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 529507001628 trehalose repressor; Provisional; Region: treR; PRK09492 529507001629 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 529507001630 DNA binding site [nucleotide binding] 529507001631 domain linker motif; other site 529507001632 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 529507001633 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 0.0015 529507001634 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 9.7e-09 529507001635 Predicted helix-turn-helix motif with score 2310.000, SD 7.05 at aa 9-30, sequence LTINDIAKLCGVGKSTVSRVLN 529507001636 Signal peptide predicted for PMI0294 by SignalP 2.0 HMM (Signal peptide probability 0.977) with cleavage site probability 0.618 between residues 25 and 26 529507001637 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 529507001638 1 probable transmembrane helix predicted for PMI0295 by TMHMM2.0 at aa 164-185 529507001639 fimbrial operon 3 529507001640 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507001641 non-specific DNA binding site [nucleotide binding]; other site 529507001642 salt bridge; other site 529507001643 sequence-specific DNA binding site [nucleotide binding]; other site 529507001644 HMMPfam hit to PF01381, Helix-turn-helix, score 2.8e-15 529507001645 Predicted helix-turn-helix motif with score 2289.000, SD 6.98 at aa 34-55, sequence LTGEDLAKKLNVSQQQVSRYET 529507001646 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507001647 Signal peptide predicted for PMI0297 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 23 and 24 529507001648 HMMPfam hit to PF00419, Fimbrial protein, score 5.6e-23 529507001649 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507001650 Signal peptide predicted for PMI0298 by SignalP 2.0 HMM (Signal peptide probability 0.839) with cleavage site probability 0.799 between residues 29 and 30 529507001651 HMMPfam hit to PF00419, Fimbrial protein, score 1.2e-06 529507001652 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 529507001653 PapC N-terminal domain; Region: PapC_N; pfam13954 529507001654 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 529507001655 PapC C-terminal domain; Region: PapC_C; pfam13953 529507001656 Signal peptide predicted for PMI0299 by SignalP 2.0 HMM (Signal peptide probability 0.950) with cleavage site probability 0.945 between residues 31 and 32 529507001657 HMMPfam hit to PF00577, Fimbrial Usher protein, score 5.7e-244 529507001658 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 529507001659 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 529507001660 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 529507001661 Signal peptide predicted for PMI0300 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.965 between residues 33 and 34 529507001662 1 probable transmembrane helix predicted for PMI0300 by TMHMM2.0 at aa 13-35 529507001663 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 6e-44 529507001664 PS00635 Gram-negative pili assembly chaperone signature. 529507001665 Signal peptide predicted for PMI0301 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.959 between residues 30 and 31 529507001666 1 probable transmembrane helix predicted for PMI0301 by TMHMM2.0 at aa 12-30 529507001667 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507001668 Signal peptide predicted for PMI0302 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.876 between residues 24 and 25 529507001669 HMMPfam hit to PF00419, Fimbrial protein, score 3.5e-06 529507001670 Fimbrial protein; Region: Fimbrial; pfam00419 529507001671 Signal peptide predicted for PMI0303 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 25 and 26 529507001672 1 probable transmembrane helix predicted for PMI0303 by TMHMM2.0 at aa 12-34 529507001673 HMMPfam hit to PF00419, Fimbrial protein, score 0.0028 529507001674 Signal peptide predicted for PMI0304 by SignalP 2.0 HMM (Signal peptide probability 0.884) with cleavage site probability 0.865 between residues 50 and 51 529507001675 1 probable transmembrane helix predicted for PMI0304 by TMHMM2.0 at aa 28-50 529507001676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 529507001677 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 529507001678 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 1.6e-07 529507001679 HMMPfam hit to PF02178, AT hook motif, score 0.025 529507001680 putrescine transporter; Provisional; Region: potE; PRK10655 529507001681 HMMPfam hit to PF00324, Amino acid permease, score 7.9e-07 529507001682 12 probable transmembrane helices predicted for PMI0306 by TMHMM2.0 at aa 2-24, 29-51, 80-102, 112-134, 141-163, 178-197, 218-240, 260-282, 317-334, 344-366, 379-397 and 402-421 529507001683 PS00017 ATP/GTP-binding site motif A (P-loop). 529507001684 ornithine decarboxylase; Provisional; Region: PRK13578 529507001685 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 529507001686 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 529507001687 homodimer interface [polypeptide binding]; other site 529507001688 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507001689 catalytic residue [active] 529507001690 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 529507001691 HMMPfam hit to PF03711, Orn/Lys/Arg decarboxylase, C-terminal doma, score 5.4e-82 529507001692 HMMPfam hit to PF01276, Orn/Lys/Arg decarboxylase, major domain, score 0 529507001693 PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site. 529507001694 HMMPfam hit to PF03709, Orn/Lys/Arg decarboxylase, N-terminal doma, score 1.6e-19 529507001695 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 529507001696 active site 529507001697 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 529507001698 resolvase/recombinase (pseudogene);This CDS appears to have a frameshift mutation following codon 126. 529507001699 HMMPfam hit to PF00239, Resolvase, N terminal domain, score 8.5e-49 529507001700 PS00397 Site-specific recombinases active site. 529507001701 PS00398 Site-specific recombinases signature 2. 529507001702 HMMPfam hit to PF02796, Helix-turn-helix domain of resolvase, score 1.9e-10 529507001703 Predicted helix-turn-helix motif with score 1736.000, SD 5.10 at aa 26-47, sequence WGGTAIAKEMKVARSTVYKILN 529507001704 2 probable transmembrane helices predicted for PMI0311 by TMHMM2.0 at aa 10-32 and 52-74 529507001705 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 529507001706 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 529507001707 active site 529507001708 phage-related protein (fragment) 529507001709 PS00017 ATP/GTP-binding site motif A (P-loop). 529507001710 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 529507001711 Signal peptide predicted for PMI0317 by SignalP 2.0 HMM (Signal peptide probability 0.673) with cleavage site probability 0.620 between residues 18 and 19 529507001712 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507001713 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 529507001714 Signal peptide predicted for PMI0318 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.973 between residues 28 and 29 529507001715 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 529507001716 2 probable transmembrane helices predicted for PMI0319 by TMHMM2.0 at aa 41-58 and 62-81 529507001717 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 529507001718 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 529507001719 Transposase; Region: HTH_Tnp_1; pfam01527 529507001720 HMMPfam hit to PF01527, Transposase, score 6e-18 529507001721 Predicted helix-turn-helix motif with score 1043.000, SD 2.74 at aa 26-47, sequence YSVSKAAASLGITDKLLYNWKA 529507001722 integrase (fragment) 529507001723 murein transglycosylase C; Provisional; Region: mltC; PRK11671 529507001724 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 529507001725 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 529507001726 N-acetyl-D-glucosamine binding site [chemical binding]; other site 529507001727 catalytic residue [active] 529507001728 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 1.2e-45 529507001729 PS00922 Prokaryotic transglycosylases signature. 529507001730 oxidative damage protection protein; Provisional; Region: PRK05408 529507001731 HMMPfam hit to PF04362, Protein of unknown function (DUF495), score 3.4e-66 529507001732 adenine DNA glycosylase; Provisional; Region: PRK10880 529507001733 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 529507001734 minor groove reading motif; other site 529507001735 helix-hairpin-helix signature motif; other site 529507001736 substrate binding pocket [chemical binding]; other site 529507001737 active site 529507001738 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 529507001739 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 529507001740 DNA binding and oxoG recognition site [nucleotide binding] 529507001741 PS00764 Endonuclease III iron-sulfur binding region signature. 529507001742 HMMPfam hit to PF00730, HhH-GPD superfamily base excision DNA repair, score 2.8e-23 529507001743 PS01155 Endonuclease III family signature. 529507001744 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 1.8e-05 529507001745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507001746 S-adenosylmethionine binding site [chemical binding]; other site 529507001747 HMMPfam hit to PF02390, methyltransferase, score 3.4e-96 529507001748 hypothetical protein; Provisional; Region: PRK11702 529507001749 HMMPfam hit to PF04320, Protein with unknown function (DUF469), score 3.6e-71 529507001750 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 529507001751 glutaminase; Provisional; Region: PRK00971 529507001752 HMMPfam hit to PF04960, Glutaminase, score 3.4e-174 529507001753 hypothetical protein; Provisional; Region: PRK10626 529507001754 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 529507001755 Signal peptide predicted for PMI0330 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.945 between residues 19 and 20 529507001756 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 529507001757 putative ligand binding residues [chemical binding]; other site 529507001758 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 529507001759 Signal peptide predicted for PMI0331 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.909 between residues 22 and 23 529507001760 HMMPfam hit to PF01497, Periplasmic binding protein, score 1.7e-39 529507001761 HemN family oxidoreductase; Provisional; Region: PRK05660 529507001762 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 529507001763 FeS/SAM binding site; other site 529507001764 HemN C-terminal domain; Region: HemN_C; pfam06969 529507001765 HMMPfam hit to PF06969, HemN C-terminal region, score 5.7e-20 529507001766 Predicted helix-turn-helix motif with score 1576.000, SD 4.55 at aa 326-347, sequence FPRQDFSDYTGLAQETIRRQID 529507001767 HMMPfam hit to PF04055, Radical SAM superfamily, score 8.4e-25 529507001768 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 529507001769 active site 529507001770 dimerization interface [polypeptide binding]; other site 529507001771 HMMPfam hit to PF01725, Ham1 family, score 1.8e-99 529507001772 YGGT family; Region: YGGT; pfam02325 529507001773 YGGT family; Region: YGGT; pfam02325 529507001774 HMMPfam hit to PF02325, YGGT family, score 9.3e-23 529507001775 4 probable transmembrane helices predicted for PMI0334 by TMHMM2.0 at aa 3-25, 66-88, 95-117 and 149-171 529507001776 HMMPfam hit to PF02325, YGGT family, score 1.2e-18 529507001777 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 529507001778 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 529507001779 HMMPfam hit to PF01089, Delta 1-pyrroline-5-carboxylate reductase, score 2.8e-93 529507001780 PS00107 Protein kinases ATP-binding region signature. 529507001781 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 529507001782 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 529507001783 catalytic residue [active] 529507001784 HMMPfam hit to PF01168, Alanine racemase, N-terminal domain, score 4.5e-41 529507001785 PS01211 Uncharacterized protein family UPF0001 signature. 529507001786 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 529507001787 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 529507001788 Walker A motif; other site 529507001789 ATP binding site [chemical binding]; other site 529507001790 Walker B motif; other site 529507001791 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 7e-12 529507001792 PS00017 ATP/GTP-binding site motif A (P-loop). 529507001793 PS00662 Bacterial type II secretion system protein E signature. 529507001794 Predicted helix-turn-helix motif with score 1060.000, SD 2.80 at aa 302-323, sequence TTLMQTGFEYGMQTFTLSRQQR 529507001795 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 529507001796 HMMPfam hit to PF03652, Uncharacterised protein family (UPF0081), score 8.4e-66 529507001797 hypothetical protein; Validated; Region: PRK00228 529507001798 HMMPfam hit to PF02622, Uncharacterized ACR, COG1678, score 7.6e-92 529507001799 glutathione synthetase; Provisional; Region: PRK05246 529507001800 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 529507001801 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 529507001802 HMMPfam hit to PF02955, Prokaryotic glutathione synthetase, ATP-gra, score 1.7e-127 529507001803 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 529507001804 HMMPfam hit to PF02951, Prokaryotic glutathione synthetase, N-termi, score 9e-66 529507001805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 529507001806 RNA methyltransferase, RsmE family; Region: TIGR00046 529507001807 HMMPfam hit to PF04452, Protein of unknown function (DUF558), score 4.5e-41 529507001808 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 529507001809 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 529507001810 Signal peptide predicted for PMI0342 by SignalP 2.0 HMM (Signal peptide probability 0.741) with cleavage site probability 0.739 between residues 30 and 31 529507001811 5 probable transmembrane helices predicted for PMI0342 by TMHMM2.0 at aa 45-67, 87-109, 116-138, 158-180 and 187-209 529507001812 HMMPfam hit to PF01478, Type IV leader peptidase family, score 4.1e-17 529507001813 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 529507001814 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 529507001815 catalytic residues [active] 529507001816 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 529507001817 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 1.1e-12 529507001818 1 probable transmembrane helix predicted for PMI0344 by TMHMM2.0 at aa 19-41 529507001819 Signal peptide predicted for PMI0344 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 36 and 37 529507001820 Transcriptional regulator [Transcription]; Region: LysR; COG0583 529507001821 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507001822 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 529507001823 putative effector binding pocket; other site 529507001824 dimerization interface [polypeptide binding]; other site 529507001825 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.1e-10 529507001826 Predicted helix-turn-helix motif with score 1757.000, SD 5.17 at aa 17-38, sequence GSMIKAADYLGMSRAMVTRYLN 529507001827 PS00044 Bacterial regulatory proteins, lysR family signature. 529507001828 HMMPfam hit to PF03466, LysR substrate binding domain, score 7e-45 529507001829 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 529507001830 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507001831 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 529507001832 dimerization interface [polypeptide binding]; other site 529507001833 HMMPfam hit to PF03466, LysR substrate binding domain, score 8.6e-39 529507001834 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.1e-16 529507001835 PS00044 Bacterial regulatory proteins, lysR family signature. 529507001836 Predicted helix-turn-helix motif with score 1850.000, SD 5.49 at aa 20-41, sequence QNLTEAADLLKTSQPTVSRELS 529507001837 diaminopimelate decarboxylase; Provisional; Region: PRK11165 529507001838 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 529507001839 active site 529507001840 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 529507001841 substrate binding site [chemical binding]; other site 529507001842 catalytic residues [active] 529507001843 dimer interface [polypeptide binding]; other site 529507001844 HMMPfam hit to PF02784, Pyridoxal-dependent decarboxylase, py, score 1.1e-64 529507001845 PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 529507001846 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 529507001847 HMMPfam hit to PF00278, Pyridoxal-dependent decarboxylase, C-, score 1.5e-50 529507001848 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 529507001849 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 529507001850 active site 529507001851 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 529507001852 HMMPfam hit to PF00441, Acyl-CoA dehydrogenase, C-terminal doma, score 1.1e-26 529507001853 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal doma, score 2.4e-05 529507001854 2 probable transmembrane helices predicted for PMI0348 by TMHMM2.0 at aa 4-18 and 25-47 529507001855 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 529507001856 dimer interface [polypeptide binding]; other site 529507001857 active site 529507001858 HMMPfam hit to PF01380, SIS domain, score 1.7e-23 529507001859 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 529507001860 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 529507001861 putative active site [active] 529507001862 putative dimer interface [polypeptide binding]; other site 529507001863 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 8.6e-23 529507001864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 529507001865 HMMPfam hit to PF06104, Bacterial protein of unknown function (DUF94, score 2.2e-107 529507001866 Signal peptide predicted for PMI0351 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.996 between residues 23 and 24 529507001867 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 529507001868 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 529507001869 HMMPfam hit to PF05896, Na(+)-translocating NADH-quinone reductase s, score 5.8e-286 529507001870 PS00191 Cytochrome b5 family, heme-binding domain signature. 529507001871 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 529507001872 HMMPfam hit to PF03116, NQR2, RnfD, RnfE family, score 1.7e-204 529507001873 8 probable transmembrane helices predicted for PMI0353 by TMHMM2.0 at aa 58-80, 125-147, 159-181, 268-290, 297-316, 326-345, 358-375 and 379-401 529507001874 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 529507001875 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 529507001876 Signal peptide predicted for PMI0354 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.871 between residues 29 and 30 529507001877 1 probable transmembrane helix predicted for PMI0354 by TMHMM2.0 at aa 13-35 529507001878 HMMPfam hit to PF04205, FMN-binding domain, score 6.8e-17 529507001879 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 529507001880 HMMPfam hit to PF02508, Rnf-Nqr subunit, membrane protein, score 1.4e-94 529507001881 5 probable transmembrane helices predicted for PMI0355 by TMHMM2.0 at aa 40-62, 72-94, 101-123, 138-156 and 177-199 529507001882 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 529507001883 HMMPfam hit to PF02508, Rnf-Nqr subunit, membrane protein, score 6.6e-115 529507001884 6 probable transmembrane helices predicted for PMI0356 by TMHMM2.0 at aa 12-31, 41-63, 76-98, 108-130, 139-161 and 176-196 529507001885 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 529507001886 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 529507001887 catalytic loop [active] 529507001888 iron binding site [ion binding]; other site 529507001889 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 529507001890 FAD binding pocket [chemical binding]; other site 529507001891 FAD binding motif [chemical binding]; other site 529507001892 phosphate binding motif [ion binding]; other site 529507001893 beta-alpha-beta structure motif; other site 529507001894 NAD binding pocket [chemical binding]; other site 529507001895 Signal peptide predicted for PMI0357 by SignalP 2.0 HMM (Signal peptide probability 0.980) with cleavage site probability 0.946 between residues 25 and 26 529507001896 1 probable transmembrane helix predicted for PMI0357 by TMHMM2.0 at aa 3-25 529507001897 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding doma, score 2.2e-13 529507001898 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507001899 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 3.5e-23 529507001900 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 529507001901 ApbE family; Region: ApbE; pfam02424 529507001902 Signal peptide predicted for PMI0358 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.700 between residues 23 and 24 529507001903 HMMPfam hit to PF02424, ApbE family, score 4.9e-113 529507001904 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507001905 Protein of unknown function (DUF539); Region: DUF539; cl01129 529507001906 Signal peptide predicted for PMI0359 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.819 between residues 22 and 23 529507001907 HMMPfam hit to PF04400, Protein of unknown function (DUF539), score 8.3e-24 529507001908 CsbD-like; Region: CsbD; cl17424 529507001909 HMMPfam hit to PF05532, CsbD-like, score 3.4e-14 529507001910 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 529507001911 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 529507001912 putative active site [active] 529507001913 catalytic site [active] 529507001914 putative metal binding site [ion binding]; other site 529507001915 HMMPfam hit to PF03009, Glycerophosphoryl diester phosphodiesterase, score 3e-20 529507001916 Signal peptide predicted for PMI0361 by SignalP 2.0 HMM (Signal peptide probability 0.917) with cleavage site probability 0.813 between residues 19 and 20 529507001917 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 529507001918 active site 529507001919 DNA polymerase IV; Validated; Region: PRK02406 529507001920 DNA binding site [nucleotide binding] 529507001921 HMMPfam hit to PF00817, impB/mucB/samB family, score 3.8e-114 529507001922 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 529507001923 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 529507001924 N-terminal plug; other site 529507001925 ligand-binding site [chemical binding]; other site 529507001926 HMMPfam hit to PF00593, TonB dependent receptor, score 1.3e-21 529507001927 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 1.4e-26 529507001928 Signal peptide predicted for PMI0363 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.792 between residues 25 and 26 529507001929 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 529507001930 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 529507001931 metal binding site [ion binding]; metal-binding site 529507001932 dimer interface [polypeptide binding]; other site 529507001933 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 1.9e-15 529507001934 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 529507001935 active site 529507001936 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 1.6e-19 529507001937 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 529507001938 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 529507001939 HMMPfam hit to PF06500, Protein of unknown function (DUF1100), score 6.5e-207 529507001940 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 529507001941 HMMPfam hit to PF07417, Transcriptional regulator Crl, score 2.7e-52 529507001942 gamma-glutamyl kinase; Provisional; Region: PRK05429 529507001943 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 529507001944 nucleotide binding site [chemical binding]; other site 529507001945 homotetrameric interface [polypeptide binding]; other site 529507001946 putative phosphate binding site [ion binding]; other site 529507001947 putative allosteric binding site; other site 529507001948 PUA domain; Region: PUA; pfam01472 529507001949 HMMPfam hit to PF00696, Amino acid kinase family, score 3.4e-59 529507001950 PS00902 Glutamate 5-kinase signature. 529507001951 HMMPfam hit to PF01472, PUA domain, score 5.7e-26 529507001952 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 529507001953 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 529507001954 putative catalytic cysteine [active] 529507001955 PS01223 Gamma-glutamyl phosphate reductase signature. 529507001956 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 529507001957 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 529507001958 ADP binding site [chemical binding]; other site 529507001959 magnesium binding site [ion binding]; other site 529507001960 putative shikimate binding site; other site 529507001961 PS00017 ATP/GTP-binding site motif A (P-loop). 529507001962 HMMPfam hit to PF01202, Shikimate kinase, score 1.6e-59 529507001963 PS01128 Shikimate kinase signature. 529507001964 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 529507001965 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 529507001966 putative acyl-acceptor binding pocket; other site 529507001967 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 529507001968 acyl-activating enzyme (AAE) consensus motif; other site 529507001969 putative AMP binding site [chemical binding]; other site 529507001970 HMMPfam hit to PF01553, Acyltransferase, score 7.2e-27 529507001971 HMMPfam hit to PF00501, AMP-binding enzyme, score 1.5e-67 529507001972 PS00455 AMP-binding domain signature. 529507001973 PS00215 Mitochondrial energy transfer proteins signature. 529507001974 lysophospholipid transporter LplT; Provisional; Region: PRK11195 529507001975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507001976 putative substrate translocation pore; other site 529507001977 10 probable transmembrane helices predicted for PMI0373 by TMHMM2.0 at aa 17-39, 52-71, 92-114, 161-183, 219-241, 256-278, 285-302, 307-329, 342-364 and 369-391 529507001978 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.7e-18 529507001979 hypothetical protein; Validated; Region: PRK03661 529507001980 HMMPfam hit to PF02464, Competence-damaged protein, score 1.1e-78 529507001981 recombinase A; Provisional; Region: recA; PRK09354 529507001982 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 529507001983 hexamer interface [polypeptide binding]; other site 529507001984 Walker A motif; other site 529507001985 ATP binding site [chemical binding]; other site 529507001986 Walker B motif; other site 529507001987 HMMPfam hit to PF00154, recA bacterial DNA recombination protein, score 5.9e-243 529507001988 PS00017 ATP/GTP-binding site motif A (P-loop). 529507001989 PS00321 recA signature. 529507001990 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 529507001991 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 529507001992 motif 1; other site 529507001993 active site 529507001994 motif 2; other site 529507001995 motif 3; other site 529507001996 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 529507001997 DHHA1 domain; Region: DHHA1; pfam02272 529507001998 HMMPfam hit to PF01411, tRNA synthetases class II (A), score 0 529507001999 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 529507002000 HMMPfam hit to PF02272, DHHA1 domain, score 8e-22 529507002001 carbon storage regulator; Provisional; Region: PRK01712 529507002002 HMMPfam hit to PF02599, Global regulator protein family, score 1.5e-34 529507002003 glutamate--cysteine ligase; Provisional; Region: PRK02107 529507002004 HMMPfam hit to PF04262, Glutamate-cysteine ligase, score 1.1e-247 529507002005 S-ribosylhomocysteinase; Provisional; Region: PRK02260 529507002006 HMMPfam hit to PF02664, S-Ribosylhomocysteinase (LuxS), score 2.5e-105 529507002007 hypothetical protein; Provisional; Region: PRK11573 529507002008 Domain of unknown function DUF21; Region: DUF21; pfam01595 529507002009 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 529507002010 Transporter associated domain; Region: CorC_HlyC; smart01091 529507002011 HMMPfam hit to PF03471, Transporter associated domain, score 4e-23 529507002012 HMMPfam hit to PF00571, CBS domain, score 1.4e-06 529507002013 HMMPfam hit to PF00571, CBS domain, score 0.071 529507002014 HMMPfam hit to PF01595, Domain of unknown function DUF21, score 3.9e-68 529507002015 4 probable transmembrane helices predicted for PMI0380 by TMHMM2.0 at aa 4-26, 62-84, 94-112 and 124-146 529507002016 Signal peptide predicted for PMI0380 by SignalP 2.0 HMM (Signal peptide probability 0.893) with cleavage site probability 0.652 between residues 24 and 25 529507002017 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 529507002018 HMMPfam hit to PF01578, Cytochrome C assembly protein, score 1.7e-61 529507002019 8 probable transmembrane helices predicted for PMI0381 by TMHMM2.0 at aa 24-46, 56-78, 85-107, 112-134, 147-169, 199-221, 233-250 and 260-282 529507002020 signal recognition particle protein; Provisional; Region: PRK10867 529507002021 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 529507002022 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 529507002023 P loop; other site 529507002024 GTP binding site [chemical binding]; other site 529507002025 Signal peptide binding domain; Region: SRP_SPB; pfam02978 529507002026 HMMPfam hit to PF02881, SRP54-type protein, helical bundle domain, score 1.4e-32 529507002027 HMMPfam hit to PF00448, SRP54-type protein, GTPase domain, score 4.5e-119 529507002028 PS00017 ATP/GTP-binding site motif A (P-loop). 529507002029 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 529507002030 PS00300 SRP54-type proteins GTP-binding domain signature. 529507002031 HMMPfam hit to PF02978, Signal peptide binding domain, score 2.1e-48 529507002032 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 529507002033 PS00732 Ribosomal protein S16 signature. 529507002034 HMMPfam hit to PF00886, Ribosomal protein S16, score 2.6e-33 529507002035 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 529507002036 RimM N-terminal domain; Region: RimM; pfam01782 529507002037 PRC-barrel domain; Region: PRC; pfam05239 529507002038 HMMPfam hit to PF01782, RimM N-terminal domain, score 1.5e-30 529507002039 HMMPfam hit to PF05239, PRC-barrel domain, score 4.2e-19 529507002040 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 529507002041 HMMPfam hit to PF01746, tRNA (Guanine-1)-methyltransferase, score 4.1e-136 529507002042 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 529507002043 HMMPfam hit to PF01245, Ribosomal protein L19, score 3.1e-78 529507002044 PS01015 Ribosomal protein L19 signature. 529507002045 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 529507002046 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 529507002047 HMMPfam hit to PF00793, DAHP synthetase I family, score 5.7e-150 529507002048 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 529507002049 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 529507002050 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 529507002051 prephenate dehydrogenase; Validated; Region: PRK08507 529507002052 HMMPfam hit to PF01817, Chorismate mutase type II, score 1.6e-33 529507002053 HMMPfam hit to PF02153, Prephenate dehydrogenase, score 5.1e-17 529507002054 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 529507002055 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 529507002056 10 probable transmembrane helices predicted for PMI0389 by TMHMM2.0 at aa 4-19, 24-43, 90-112, 143-165, 175-197, 237-256, 271-288, 301-318, 360-382 and 422-444 529507002057 HMMPfam hit to PF03605, Anaerobic c4-dicarboxylate membrane transpo, score 7.6e-243 529507002058 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 529507002059 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 529507002060 Prephenate dehydratase; Region: PDT; pfam00800 529507002061 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 529507002062 putative L-Phe binding site [chemical binding]; other site 529507002063 PS00858 Prephenate dehydratase signature 2. 529507002064 HMMPfam hit to PF00800, Prephenate dehydratase, score 4.7e-85 529507002065 PS00857 Prephenate dehydratase signature 1. 529507002066 HMMPfam hit to PF01817, Chorismate mutase type II, score 2.1e-23 529507002067 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 529507002068 30S subunit binding site; other site 529507002069 HMMPfam hit to PF02482, Sigma 54 modulation protein / S30EA r, score 9.9e-42 529507002070 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 529507002071 Signal peptide predicted for PMI0392 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.464 between residues 23 and 24 529507002072 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507002073 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 529507002074 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 529507002075 RNA binding surface [nucleotide binding]; other site 529507002076 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 529507002077 active site 529507002078 HMMPfam hit to PF01479, S4 domain, score 1.1e-10 529507002079 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 3.8e-68 529507002080 PS01129 Rlu family of pseudouridine synthase signature. 529507002081 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 529507002082 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 529507002083 HMMPfam hit to PF02578, Uncharacterised ACR, YfiH family COG1496, score 1e-76 529507002084 protein disaggregation chaperone; Provisional; Region: PRK10865 529507002085 Clp amino terminal domain; Region: Clp_N; pfam02861 529507002086 Clp amino terminal domain; Region: Clp_N; pfam02861 529507002087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 529507002088 Walker A motif; other site 529507002089 ATP binding site [chemical binding]; other site 529507002090 Walker B motif; other site 529507002091 arginine finger; other site 529507002092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 529507002093 Walker A motif; other site 529507002094 ATP binding site [chemical binding]; other site 529507002095 Walker B motif; other site 529507002096 arginine finger; other site 529507002097 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 529507002098 HMMPfam hit to PF02861, Clp amino terminal domain, score 5.6e-14 529507002099 HMMPfam hit to PF02861, Clp amino terminal domain, score 2.1e-13 529507002100 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 5.5e-15 529507002101 PS00017 ATP/GTP-binding site motif A (P-loop). 529507002102 PS00870 Chaperonins clpA/B signature 1. 529507002103 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 7.1e-111 529507002104 PS00017 ATP/GTP-binding site motif A (P-loop). 529507002105 PS00871 Chaperonins clpA/B signature 2. 529507002106 lipoprotein; Provisional; Region: PRK10759 529507002107 Signal peptide predicted for PMI0396 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.773 between residues 27 and 28 529507002108 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 529507002109 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 529507002110 domain interface [polypeptide binding]; other site 529507002111 putative active site [active] 529507002112 catalytic site [active] 529507002113 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 529507002114 domain interface [polypeptide binding]; other site 529507002115 putative active site [active] 529507002116 catalytic site [active] 529507002117 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 1e-07 529507002118 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 5.2e-05 529507002119 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 529507002120 CoA binding domain; Region: CoA_binding_2; pfam13380 529507002121 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 529507002122 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 529507002123 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 529507002124 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 529507002125 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 4.6e-12 529507002126 HMMPfam hit to PF02629, CoA binding domain, score 3.2e-07 529507002127 Uncharacterized conserved protein [Function unknown]; Region: COG3148 529507002128 HMMPfam hit to PF03942, DTW domain, score 1.5e-54 529507002129 deubiquitinase; Provisional; Region: PRK11836; cl08202 529507002130 putative methyltransferase; Provisional; Region: PRK10864 529507002131 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 529507002132 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 529507002133 HMMPfam hit to PF00588, SpoU rRNA Methylase family, score 4.2e-47 529507002134 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 529507002135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507002136 putative substrate translocation pore; other site 529507002137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507002138 13 probable transmembrane helices predicted for PMI0402 by TMHMM2.0 at aa 20-42, 57-79, 86-108, 112-134, 146-168, 173-195, 207-225, 240-259, 280-302, 312-334, 341-360, 375-397 and 481-503 529507002139 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.4e-57 529507002140 Signal peptide predicted for PMI0402 by SignalP 2.0 HMM (Signal peptide probability 0.864) with cleavage site probability 0.718 between residues 41 and 42 529507002141 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 529507002142 HlyD family secretion protein; Region: HlyD_3; pfam13437 529507002143 HMMPfam hit to PF00529, HlyD family secretion protein, score 3.4e-72 529507002144 1 probable transmembrane helix predicted for PMI0403 by TMHMM2.0 at aa 24-46 529507002145 Signal peptide predicted for PMI0403 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.617 between residues 38 and 39 529507002146 Transcriptional regulators [Transcription]; Region: GntR; COG1802 529507002147 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 529507002148 DNA-binding site [nucleotide binding]; DNA binding site 529507002149 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 529507002150 HMMPfam hit to PF07729, FCD domain, score 2.6e-16 529507002151 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 1.3e-12 529507002152 drug efflux system protein MdtG; Provisional; Region: PRK09874 529507002153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507002154 putative substrate translocation pore; other site 529507002155 12 probable transmembrane helices predicted for PMI0405 by TMHMM2.0 at aa 25-47, 62-84, 96-115, 120-142, 149-171, 181-203, 224-245, 265-287, 294-313, 323-345, 357-379 and 384-406 529507002156 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.6e-47 529507002157 Isochorismatase family; Region: Isochorismatase; pfam00857 529507002158 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 529507002159 catalytic triad [active] 529507002160 conserved cis-peptide bond; other site 529507002161 HMMPfam hit to PF00857, Isochorismatase family, score 4.3e-17 529507002162 transcriptional repressor MprA; Provisional; Region: PRK10870 529507002163 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 529507002164 HMMPfam hit to PF01047, MarR family, score 2.3e-34 529507002165 PS01117 Bacterial regulatory proteins, marR family signature. 529507002166 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 529507002167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507002168 11 probable transmembrane helices predicted for PMI0408 by TMHMM2.0 at aa 17-39, 54-76, 83-102, 106-128, 141-160, 170-192, 223-245, 255-277, 290-312, 348-370 and 375-397 529507002169 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.4e-44 529507002170 Signal peptide predicted for PMI0408 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.634 between residues 36 and 37 529507002171 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 529507002172 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 529507002173 N-terminal plug; other site 529507002174 ligand-binding site [chemical binding]; other site 529507002175 1 probable transmembrane helix predicted for PMI0409 by TMHMM2.0 at aa 2-24 529507002176 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 2.8e-15 529507002177 HMMPfam hit to PF00593, TonB dependent receptor, score 2.3e-19 529507002178 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 529507002179 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 529507002180 HMMPfam hit to PF04069, Substrate binding domain of ABC-type glycine, score 1.4e-76 529507002181 Signal peptide predicted for PMI0410 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 22 and 23 529507002182 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 529507002183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507002184 dimer interface [polypeptide binding]; other site 529507002185 conserved gate region; other site 529507002186 putative PBP binding loops; other site 529507002187 ABC-ATPase subunit interface; other site 529507002188 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.9e-33 529507002189 6 probable transmembrane helices predicted for PMI0411 by TMHMM2.0 at aa 144-166, 176-194, 201-223, 249-271, 324-346 and 350-372 529507002190 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 529507002191 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 529507002192 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 529507002193 Walker A/P-loop; other site 529507002194 ATP binding site [chemical binding]; other site 529507002195 Q-loop/lid; other site 529507002196 ABC transporter signature motif; other site 529507002197 Walker B; other site 529507002198 D-loop; other site 529507002199 H-loop/switch region; other site 529507002200 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 529507002201 HMMPfam hit to PF00571, CBS domain, score 4e-05 529507002202 HMMPfam hit to PF00005, ABC transporter, score 3.5e-68 529507002203 PS00211 ABC transporters family signature. 529507002204 PS00017 ATP/GTP-binding site motif A (P-loop). 529507002205 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 529507002206 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 529507002207 dimer interface [polypeptide binding]; other site 529507002208 putative radical transfer pathway; other site 529507002209 diiron center [ion binding]; other site 529507002210 tyrosyl radical; other site 529507002211 HMMPfam hit to PF00268, Ribonucleotide reductase, small chain, score 3.3e-93 529507002212 PS00368 Ribonucleotide reductase small subunit signature. 529507002213 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 529507002214 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 529507002215 Class I ribonucleotide reductase; Region: RNR_I; cd01679 529507002216 active site 529507002217 dimer interface [polypeptide binding]; other site 529507002218 catalytic residues [active] 529507002219 effector binding site; other site 529507002220 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 529507002221 HMMPfam hit to PF02867, Ribonucleotide reductase, barrel doma, score 1e-217 529507002222 PS00089 Ribonucleotide reductase large subunit signature. 529507002223 HMMPfam hit to PF00317, Ribonucleotide reductase, all-alpha d, score 5.5e-27 529507002224 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 529507002225 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 529507002226 catalytic residues [active] 529507002227 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 529507002228 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 529507002229 DNA binding site [nucleotide binding] 529507002230 active site 529507002231 HMMPfam hit to PF01035, 6-O-methylguanine DNA methyltransferas, score 4e-38 529507002232 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 529507002233 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 529507002234 DNA-binding site [nucleotide binding]; DNA binding site 529507002235 RNA-binding motif; other site 529507002236 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 3.5e-42 529507002237 PS00352 'Cold-shock' DNA-binding domain signature. 529507002238 chromosome condensation membrane protein; Provisional; Region: PRK14196 529507002239 4 probable transmembrane helices predicted for PMI0419 by TMHMM2.0 at aa 5-23, 33-55, 67-89 and 99-121 529507002240 HMMPfam hit to PF02537, CrcB-like protein, score 2.9e-39 529507002241 lipoyl synthase; Provisional; Region: PRK05481 529507002242 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 529507002243 FeS/SAM binding site; other site 529507002244 HMMPfam hit to PF04055, Radical SAM superfamily, score 5.2e-26 529507002245 lipoate-protein ligase B; Provisional; Region: PRK14342 529507002246 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase famil, score 8.3e-30 529507002247 PS01313 Lipoate-protein ligase B signature. 529507002248 hypothetical protein; Provisional; Region: PRK04998 529507002249 HMMPfam hit to PF04359, Protein of unknown function (DUF493), score 6.2e-55 529507002250 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 529507002251 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 529507002252 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 529507002253 HMMPfam hit to PF07943, Penicillin-binding protein 5, C-termina, score 8.2e-38 529507002254 HMMPfam hit to PF00768, D-alanyl-D-alanine carboxypeptidase, score 2.1e-141 529507002255 Signal peptide predicted for PMI0423 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 30 and 31 529507002256 1 probable transmembrane helix predicted for PMI0423 by TMHMM2.0 at aa 13-30 529507002257 rare lipoprotein A; Provisional; Region: PRK10672 529507002258 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 529507002259 Sporulation related domain; Region: SPOR; pfam05036 529507002260 HMMPfam hit to PF05036, Sporulation related repeat, score 6.6e-08 529507002261 HMMPfam hit to PF05036, Sporulation related repeat, score 0.0014 529507002262 HMMPfam hit to PF03330, Rare lipoprotein A (RlpA)-like double-psi be, score 4.2e-09 529507002263 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507002264 cell wall shape-determining protein; Provisional; Region: PRK10794 529507002265 HMMPfam hit to PF01098, Cell cycle protein, score 1.6e-165 529507002266 9 probable transmembrane helices predicted for PMI0425 by TMHMM2.0 at aa 15-37, 50-67, 77-99, 137-156, 160-179, 181-203, 272-294, 306-328 and 338-360 529507002267 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 529507002268 Signal peptide predicted for PMI0425 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.976 between residues 40 and 41 529507002269 penicillin-binding protein 2; Provisional; Region: PRK10795 529507002270 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 529507002271 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 529507002272 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 2.9e-94 529507002273 HMMPfam hit to PF03717, Penicillin-binding Protein dimerisatio, score 2.6e-65 529507002274 1 probable transmembrane helix predicted for PMI0426 by TMHMM2.0 at aa 29-51 529507002275 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 529507002276 HMMPfam hit to PF02590, Uncharacterized ACR, COG1576, score 4.4e-81 529507002277 ribosome-associated protein; Provisional; Region: PRK11538 529507002278 HMMPfam hit to PF02410, Domain of unknown function DUF143, score 1.9e-48 529507002279 PS00017 ATP/GTP-binding site motif A (P-loop). 529507002280 Uncharacterized conserved protein [Function unknown]; Region: COG3272 529507002281 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 529507002282 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 529507002283 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 529507002284 active site 529507002285 (T/H)XGH motif; other site 529507002286 HMMPfam hit to PF01467, Cytidylyltransferase, score 2.4e-55 529507002287 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 529507002288 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 529507002289 HMMPfam hit to PF06144, DNA polymerase III, delta subunit, score 2e-115 529507002290 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 529507002291 HMMPfam hit to PF04390, Rare lipoprotein B family, score 1.3e-57 529507002292 PS00017 ATP/GTP-binding site motif A (P-loop). 529507002293 Signal peptide predicted for PMI0432 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.889 between residues 25 and 26 529507002294 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507002295 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 529507002296 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 529507002297 HIGH motif; other site 529507002298 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 529507002299 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 529507002300 active site 529507002301 KMSKS motif; other site 529507002302 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 529507002303 tRNA binding surface [nucleotide binding]; other site 529507002304 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 529507002305 PS00216 Sugar transport proteins signature 1. 529507002306 HMMPfam hit to PF00133, tRNA synthetases class I (I, L, M and V), score 1.7e-271 529507002307 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 529507002308 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 529507002309 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 529507002310 Walker A/P-loop; other site 529507002311 ATP binding site [chemical binding]; other site 529507002312 Q-loop/lid; other site 529507002313 ABC transporter signature motif; other site 529507002314 Walker B; other site 529507002315 D-loop; other site 529507002316 H-loop/switch region; other site 529507002317 HMMPfam hit to PF00005, ABC transporter, score 1.3e-63 529507002318 PS00211 ABC transporters family signature. 529507002319 PS00017 ATP/GTP-binding site motif A (P-loop). 529507002320 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 529507002321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507002322 dimer interface [polypeptide binding]; other site 529507002323 conserved gate region; other site 529507002324 putative PBP binding loops; other site 529507002325 ABC-ATPase subunit interface; other site 529507002326 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 9.8e-26 529507002327 5 probable transmembrane helices predicted for PMI0435 by TMHMM2.0 at aa 20-42, 55-77, 97-116, 144-166 and 197-219 529507002328 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 529507002329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507002330 dimer interface [polypeptide binding]; other site 529507002331 conserved gate region; other site 529507002332 putative PBP binding loops; other site 529507002333 ABC-ATPase subunit interface; other site 529507002334 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.3e-32 529507002335 4 probable transmembrane helices predicted for PMI0436 by TMHMM2.0 at aa 49-71, 84-106, 126-145 and 229-251 529507002336 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 529507002337 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 529507002338 substrate binding pocket [chemical binding]; other site 529507002339 membrane-bound complex binding site; other site 529507002340 hinge residues; other site 529507002341 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 7.7e-54 529507002342 Signal peptide predicted for PMI0437 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 21 and 22 529507002343 Signal peptide predicted for PMI0438 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.342 between residues 32 and 33 529507002344 2 probable transmembrane helices predicted for PMI0438 by TMHMM2.0 at aa 13-32 and 84-106 529507002345 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 529507002346 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 529507002347 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 529507002348 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 529507002349 DsbD alpha interface [polypeptide binding]; other site 529507002350 catalytic residues [active] 529507002351 Signal peptide predicted for PMI0439 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 20 and 21 529507002352 8 probable transmembrane helices predicted for PMI0439 by TMHMM2.0 at aa 282-304, 325-347, 362-384, 411-433, 443-465, 478-496, 500-522 and 529-548 529507002353 HMMPfam hit to PF02683, Cytochrome C biogenesis protein transmembran, score 2.2e-05 529507002354 PS00194 Thioredoxin family active site. 529507002355 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 529507002356 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 529507002357 catalytic residues [active] 529507002358 Signal peptide predicted for PMI0440 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.953 between residues 21 and 22 529507002359 HMMPfam hit to PF01323, DSBA-like thioredoxin domain, score 1.1e-21 529507002360 PS00194 Thioredoxin family active site. 529507002361 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 529507002362 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 529507002363 catalytic residues [active] 529507002364 Signal peptide predicted for PMI0441 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.981 between residues 25 and 26 529507002365 1 probable transmembrane helix predicted for PMI0441 by TMHMM2.0 at aa 12-29 529507002366 1 probable transmembrane helix predicted for PMI0442 by TMHMM2.0 at aa 206-225 529507002367 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 529507002368 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 529507002369 putative active site [active] 529507002370 catalytic triad [active] 529507002371 putative dimer interface [polypeptide binding]; other site 529507002372 8 probable transmembrane helices predicted for PMI0443 by TMHMM2.0 at aa 17-34, 39-56, 63-85, 95-117, 130-149, 169-191, 198-220 and 492-509 529507002373 HMMPfam hit to PF00795, Carbon-nitrogen hydrolase, score 1e-34 529507002374 Signal peptide predicted for PMI0443 by SignalP 2.0 HMM (Signal peptide probability 0.897) with cleavage site probability 0.421 between residues 33 and 34 529507002375 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 529507002376 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 529507002377 Transporter associated domain; Region: CorC_HlyC; smart01091 529507002378 HMMPfam hit to PF03471, Transporter associated domain, score 1.3e-26 529507002379 HMMPfam hit to PF00571, CBS domain, score 9.9e-10 529507002380 HMMPfam hit to PF00571, CBS domain, score 6.9e-10 529507002381 metal-binding heat shock protein; Provisional; Region: PRK00016 529507002382 HMMPfam hit to PF02130, Uncharacterized protein family UPF0054, score 1.6e-53 529507002383 PS01306 Uncharacterized protein family UPF0054 signature. 529507002384 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 529507002385 PhoH-like protein; Region: PhoH; pfam02562 529507002386 HMMPfam hit to PF02562, PhoH-like protein, score 4.3e-152 529507002387 PS00017 ATP/GTP-binding site motif A (P-loop). 529507002388 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 529507002389 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 529507002390 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 529507002391 FeS/SAM binding site; other site 529507002392 TRAM domain; Region: TRAM; pfam01938 529507002393 HMMPfam hit to PF01938, TRAM domain, score 6.8e-22 529507002394 HMMPfam hit to PF04055, Radical SAM superfamily, score 1.3e-31 529507002395 PS01278 Uncharacterized protein family UPF0004 signature. 529507002396 HMMPfam hit to PF00919, Uncharacterized protein family UPF0004, score 3e-47 529507002397 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 529507002398 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 529507002399 HMMPfam hit to PF01360, Monooxygenase, score 1.8e-36 529507002400 S-formylglutathione hydrolase; Region: PLN02442 529507002401 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 529507002402 HMMPfam hit to PF00756, esterase, score 1.8e-100 529507002403 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 529507002404 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 529507002405 substrate binding site [chemical binding]; other site 529507002406 catalytic Zn binding site [ion binding]; other site 529507002407 NAD binding site [chemical binding]; other site 529507002408 structural Zn binding site [ion binding]; other site 529507002409 dimer interface [polypeptide binding]; other site 529507002410 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 7.4e-145 529507002411 PS00059 Zinc-containing alcohol dehydrogenases signature. 529507002412 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 529507002413 putative metal binding site [ion binding]; other site 529507002414 putative homodimer interface [polypeptide binding]; other site 529507002415 putative homotetramer interface [polypeptide binding]; other site 529507002416 putative homodimer-homodimer interface [polypeptide binding]; other site 529507002417 putative allosteric switch controlling residues; other site 529507002418 HMMPfam hit to PF02583, Uncharacterised BCR, COG1937, score 4.4e-16 529507002419 MarR family; Region: MarR; pfam01047 529507002420 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 529507002421 ROK family; Region: ROK; pfam00480 529507002422 HMMPfam hit to PF00480, ROK family, score 1.1e-73 529507002423 Predicted helix-turn-helix motif with score 1021.000, SD 2.66 at aa 36-57, sequence ISRIQIAEQSQLAPASVTKITR 529507002424 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 529507002425 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 529507002426 active site 529507002427 dimer interface [polypeptide binding]; other site 529507002428 HMMPfam hit to PF01979, Amidohydrolase family, score 3.9e-30 529507002429 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 529507002430 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 529507002431 active site 529507002432 trimer interface [polypeptide binding]; other site 529507002433 allosteric site; other site 529507002434 active site lid [active] 529507002435 hexamer (dimer of trimers) interface [polypeptide binding]; other site 529507002436 HMMPfam hit to PF01182, Glucosamine-6-phosphate isomerases/6-, score 6.6e-172 529507002437 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507002438 PS01161 Glucosamine/galactosamine-6-phosphate isomerases signature. 529507002439 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 529507002440 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 529507002441 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 529507002442 active site turn [active] 529507002443 phosphorylation site [posttranslational modification] 529507002444 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 529507002445 HPr interaction site; other site 529507002446 glycerol kinase (GK) interaction site [polypeptide binding]; other site 529507002447 active site 529507002448 phosphorylation site [posttranslational modification] 529507002449 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 5.2e-79 529507002450 9 probable transmembrane helices predicted for PMI0455 by TMHMM2.0 at aa 2-21, 31-53, 65-87, 145-167, 180-202, 242-264, 271-293, 308-330 and 343-365 529507002451 HMMPfam hit to PF00367, phosphotransferase system, EIIB, score 3.6e-16 529507002452 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 529507002453 HMMPfam hit to PF00358, phosphoenolpyruvate-dependent sugar phosph, score 1.3e-62 529507002454 PS00371 PTS EIIA domains phosphorylation site signature 1. 529507002455 prophage?? 529507002456 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 529507002457 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 529507002458 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 529507002459 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 529507002460 active site 529507002461 DNA binding site [nucleotide binding] 529507002462 Int/Topo IB signature motif; other site 529507002463 HMMPfam hit to PF00589, Phage integrase family, score 9.6e-09 529507002464 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00030 Eukaryotic RNA-binding region RNP-1 signature. 529507002465 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 0.14 529507002466 Excisionase-like protein; Region: Exc; pfam07825 529507002467 Protein of unknown function (DUF2591); Region: DUF2591; cl11584 529507002468 2 probable transmembrane helices predicted for PMI0460 by TMHMM2.0 at aa 26-48 and 63-85 529507002469 single-strand DNA-binding protein (pseudogene);This CDS contains an in-frame stop codon. 529507002470 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 529507002471 HMMPfam hit to PF03837, RecT family, score 1.4e-66 529507002472 exonuclease VIII; Reviewed; Region: PRK09709 529507002473 1 probable transmembrane helix predicted for PMI0471 by TMHMM2.0 at aa 31-50 529507002474 Signal peptide predicted for PMI0478 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.970 between residues 18 and 19 529507002475 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507002476 non-specific DNA binding site [nucleotide binding]; other site 529507002477 salt bridge; other site 529507002478 Predicted transcriptional regulator [Transcription]; Region: COG2932 529507002479 sequence-specific DNA binding site [nucleotide binding]; other site 529507002480 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 529507002481 Catalytic site [active] 529507002482 HMMPfam hit to PF00717, Peptidase S24-like, score 2.1e-16 529507002483 HMMPfam hit to PF01381, Helix-turn-helix, score 2.7e-16 529507002484 Predicted helix-turn-helix motif with score 2462.000, SD 7.57 at aa 22-43, sequence MTQAELAELVGVSPQSVQQWET 529507002485 MerR family regulatory protein; Region: MerR; pfam00376 529507002486 Predicted helix-turn-helix motif with score 1865.000, SD 5.54 at aa 12-33, sequence GGIPALAKKLKISDQAIRQWEQ 529507002487 Predicted helix-turn-helix motif with score 1523.000, SD 4.37 at aa 29-50, sequence KTQSAVARTLGVHDSTILRRTE 529507002488 Helix-turn-helix domain; Region: HTH_36; pfam13730 529507002489 Predicted helix-turn-helix motif with score 1053.000, SD 2.77 at aa 38-59, sequence PSYETIARHCEISRQSAINHIK 529507002490 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 529507002491 phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600 529507002492 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 529507002493 Walker A motif; other site 529507002494 ATP binding site [chemical binding]; other site 529507002495 Walker B motif; other site 529507002496 HMMPfam hit to PF00772, DnaB-like helicase N terminal domain, score 9.1e-35 529507002497 HMMPfam hit to PF03796, DnaB-like helicase C terminal domain, score 1.7e-75 529507002498 PS00017 ATP/GTP-binding site motif A (P-loop). 529507002499 hypothetical protein; Provisional; Region: PRK09741 529507002500 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 529507002501 HMMPfam hit to PF07102, Protein of unknown function (DUF1364), score 8.6e-63 529507002502 PS00190 Cytochrome c family heme-binding site signature. 529507002503 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 529507002504 HMMPfam hit to PF05866, Endodeoxyribonuclease RusA, score 1.5e-09 529507002505 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 529507002506 HMMPfam hit to PF06323, Phage antitermination protein Q, score 2.9e-25 529507002507 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 529507002508 4 probable transmembrane helices predicted for PMI0488 by TMHMM2.0 at aa 13-32, 78-100, 105-127 and 132-154 529507002509 HMMPfam hit to PF07274, Protein of unknown function (DUF1440), score 2e-33 529507002510 Oligosaccharyl transferase STT3 subunit; Region: STT3; pfam02516 529507002511 1 probable transmembrane helix predicted for PMI0490 by TMHMM2.0 at aa 27-49 529507002512 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 529507002513 catalytic residues [active] 529507002514 Signal peptide predicted for PMI0491 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.736 between residues 24 and 25 529507002515 1 probable transmembrane helix predicted for PMI0491 by TMHMM2.0 at aa 7-29 529507002516 HMMPfam hit to PF00959, Phage lysozyme, score 6.1e-34 529507002517 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 529507002518 HMMPfam hit to PF03245, Bacteriophage lysis protein, score 2.7e-13 529507002519 1 probable transmembrane helix predicted for PMI0492 by TMHMM2.0 at aa 6-25 529507002520 BRO family, N-terminal domain; Region: Bro-N; smart01040 529507002521 Predicted helix-turn-helix motif with score 1349.000, SD 3.78 at aa 21-42, sequence MSIREIASQYEITHQAISKRAK 529507002522 large terminase protein; Provisional; Region: 17; PHA02533 529507002523 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 529507002524 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 529507002525 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 529507002526 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 529507002527 Phage tail protein; Region: Phage_tail_3; pfam08813 529507002528 Domain of unknown function (DUF1789); Region: DUF1789; pfam08748 529507002529 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809 529507002530 2 probable transmembrane helices predicted for PMI0511 by TMHMM2.0 at aa 46-68 and 90-112 529507002531 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 529507002532 HicB family; Region: HicB; pfam05534 529507002533 Arc-like DNA binding domain; Region: Arc; pfam03869 529507002534 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 529507002535 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 529507002536 P-loop; other site 529507002537 Magnesium ion binding site [ion binding]; other site 529507002538 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 529507002539 Magnesium ion binding site [ion binding]; other site 529507002540 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 2.7e-20 529507002541 Signal peptide predicted for PMI0518 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 26 and 27 529507002542 1 probable transmembrane helix predicted for PMI0518 by TMHMM2.0 at aa 5-27 529507002543 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507002544 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 529507002545 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 529507002546 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 529507002547 HMMPfam hit to PF06791, Prophage tail length tape measure protein, score 3.8e-81 529507002548 Phage minor tail protein; Region: Phage_min_tail; pfam05939 529507002549 HMMPfam hit to PF05939, Phage minor tail protein, score 7.5e-41 529507002550 Phage-related protein [Function unknown]; Region: gp18; COG4672 529507002551 HMMPfam hit to PF05100, Phage minor tail protein L, score 1.4e-101 529507002552 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 529507002553 MPN+ (JAMM) motif; other site 529507002554 Zinc-binding site [ion binding]; other site 529507002555 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 529507002556 NlpC/P60 family; Region: NLPC_P60; cl17555 529507002557 HMMPfam hit to PF00877, NlpC/P60 family, score 2e-31 529507002558 Phage-related protein, tail component [Function unknown]; Region: COG4723 529507002559 HMMPfam hit to PF06805, Bacteriophage lambda tail assembly prot, score 3.1e-91 529507002560 2 probable transmembrane helices predicted for PMI0526 by TMHMM2.0 at aa 89-108 and 113-135 529507002561 Phage-related protein, tail component [Function unknown]; Region: COG4733 529507002562 Putative phage tail protein; Region: Phage-tail_3; pfam13550 529507002563 Fibronectin type 3 domain; Region: FN3; smart00060 529507002564 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 529507002565 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 529507002566 HMMPfam hit to PF00041, Fibronectin type III domain, score 0.037 529507002567 HMMPfam hit to PF00041, Fibronectin type III domain, score 0.034 529507002568 1 probable transmembrane helix predicted for PMI0530 by TMHMM2.0 at aa 4-26 529507002569 fimbrial operon 4 529507002570 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507002571 non-specific DNA binding site [nucleotide binding]; other site 529507002572 salt bridge; other site 529507002573 sequence-specific DNA binding site [nucleotide binding]; other site 529507002574 HMMPfam hit to PF01381, Helix-turn-helix, score 1.7e-13 529507002575 Predicted helix-turn-helix motif with score 1573.000, SD 4.54 at aa 24-45, sequence MTGREIAHSLEISQQHYSRIEN 529507002576 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507002577 HMMPfam hit to PF00419, Fimbrial protein, score 5.4e-05 529507002578 Signal peptide predicted for PMI0533 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.914 between residues 20 and 21 529507002579 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 529507002580 PapC N-terminal domain; Region: PapC_N; pfam13954 529507002581 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 529507002582 PapC C-terminal domain; Region: PapC_C; pfam13953 529507002583 HMMPfam hit to PF00577, Fimbrial Usher protein, score 0 529507002584 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 529507002585 1 probable transmembrane helix predicted for PMI0534 by TMHMM2.0 at aa 12-34 529507002586 Signal peptide predicted for PMI0534 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.936 between residues 33 and 34 529507002587 putative chaperone protein EcpD; Provisional; Region: PRK09926 529507002588 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 529507002589 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 529507002590 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 9.4e-18 529507002591 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 2.7e-65 529507002592 PS00635 Gram-negative pili assembly chaperone signature. 529507002593 1 probable transmembrane helix predicted for PMI0535 by TMHMM2.0 at aa 20-42 529507002594 Signal peptide predicted for PMI0535 by SignalP 2.0 HMM (Signal peptide probability 0.960) with cleavage site probability 0.953 between residues 37 and 38 529507002595 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507002596 HMMPfam hit to PF00419, Fimbrial protein, score 1.6e-42 529507002597 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 529507002598 1 probable transmembrane helix predicted for PMI0536 by TMHMM2.0 at aa 5-27 529507002599 Signal peptide predicted for PMI0536 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 529507002600 1 probable transmembrane helix predicted for PMI0537 by TMHMM2.0 at aa 15-37 529507002601 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; cl11635 529507002602 HMMPfam hit to PF06440, DNA polymerase III, theta subunit, score 3.9e-11 529507002603 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 529507002604 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 529507002605 active site 529507002606 HIGH motif; other site 529507002607 nucleotide binding site [chemical binding]; other site 529507002608 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 529507002609 KMSKS motif; other site 529507002610 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 529507002611 HMMPfam hit to PF00749, tRNA synthetases class I (E and Q), ca, score 4.1e-184 529507002612 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 529507002613 HMMPfam hit to PF03950, tRNA synthetases class I (E and Q), an, score 6.1e-104 529507002614 outer membrane porin, OprD family; Region: OprD; pfam03573 529507002615 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 529507002616 HMMPfam hit to PF05675, Protein of unknown function (DUF817), score 1.2e-156 529507002617 8 probable transmembrane helices predicted for PMI0542 by TMHMM2.0 at aa 27-49, 59-78, 90-112, 122-141, 154-176, 180-202, 209-231 and 251-268 529507002618 PS00340 Growth factor and cytokines receptors family signature 2. 529507002619 ferric uptake regulator; Provisional; Region: fur; PRK09462 529507002620 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 529507002621 metal binding site 2 [ion binding]; metal-binding site 529507002622 putative DNA binding helix; other site 529507002623 metal binding site 1 [ion binding]; metal-binding site 529507002624 dimer interface [polypeptide binding]; other site 529507002625 structural Zn2+ binding site [ion binding]; other site 529507002626 HMMPfam hit to PF01475, Ferric uptake regulator family, score 2.2e-68 529507002627 flavodoxin FldA; Validated; Region: PRK09267 529507002628 HMMPfam hit to PF00258, Flavodoxin, score 4.6e-53 529507002629 PS00201 Flavodoxin signature. 529507002630 LexA regulated protein; Provisional; Region: PRK11675 529507002631 HMMPfam hit to PF01402, Ribbon-helix-helix protein, copG family, score 8.9e-07 529507002632 acyl-CoA esterase; Provisional; Region: PRK10673 529507002633 PGAP1-like protein; Region: PGAP1; pfam07819 529507002634 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 4.7e-16 529507002635 replication initiation regulator SeqA; Provisional; Region: PRK11187 529507002636 HMMPfam hit to PF03925, SeqA protein, score 6.3e-95 529507002637 phosphoglucomutase; Validated; Region: PRK07564 529507002638 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 529507002639 active site 529507002640 substrate binding site [chemical binding]; other site 529507002641 metal binding site [ion binding]; metal-binding site 529507002642 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase, al, score 1.4e-42 529507002643 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 529507002644 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase, al, score 1.6e-17 529507002645 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase, al, score 3.3e-24 529507002646 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase, C-, score 5.8e-14 529507002647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 529507002648 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 529507002649 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 529507002650 HMMPfam hit to PF07308, Protein of unknown function (DUF1456), score 2.3e-32 529507002651 HMMPfam hit to PF07308, Protein of unknown function (DUF1456), score 1.2e-33 529507002652 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 529507002653 HMMPfam hit to PF03693, Uncharacterised protein family (UPF0156), score 9.3e-21 529507002654 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 529507002655 HMMPfam hit to PF05016, Plasmid stabilisation system protein, score 9.8e-20 529507002656 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 529507002657 HMMPfam hit to PF07308, Protein of unknown function (DUF1456), score 1.8e-06 529507002658 PS00017 ATP/GTP-binding site motif A (P-loop). 529507002659 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507002660 non-specific DNA binding site [nucleotide binding]; other site 529507002661 salt bridge; other site 529507002662 sequence-specific DNA binding site [nucleotide binding]; other site 529507002663 HMMPfam hit to PF01381, Helix-turn-helix, score 2e-05 529507002664 Predicted helix-turn-helix motif with score 1565.000, SD 4.52 at aa 48-69, sequence VSQSEFAHALGTSIDTVKSWEL 529507002665 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 529507002666 1 probable transmembrane helix predicted for PMI0555 by TMHMM2.0 at aa 17-39 529507002667 Uncharacterized conserved protein [Function unknown]; Region: COG0327 529507002668 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 529507002669 HMMPfam hit to PF01784, NIF3 (NGG1p interacting factor 3), score 1.4e-101 529507002670 SWIM zinc finger; Region: SWIM; pfam04434 529507002671 HMMPfam hit to PF04434, SWIM zinc finger, score 0.031 529507002672 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 529507002673 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 529507002674 metal ion-dependent adhesion site (MIDAS); other site 529507002675 HMMPfam hit to PF05762, VWA domain containing CoxE-like protein, score 5.1e-57 529507002676 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 529507002677 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 529507002678 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 1.1e-64 529507002679 HEAT repeats; Region: HEAT_2; pfam13646 529507002680 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 529507002681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507002682 Major Facilitator Superfamily; Region: MFS_1; pfam07690 529507002683 putative substrate translocation pore; other site 529507002684 12 probable transmembrane helices predicted for PMI0562 by TMHMM2.0 at aa 5-27, 42-64, 71-90, 95-117, 130-152, 157-179, 209-231, 241-263, 272-290, 294-316, 328-350 and 354-371 529507002685 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.1e-48 529507002686 Signal peptide predicted for PMI0562 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.985 between residues 20 and 21 529507002687 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 529507002688 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 529507002689 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.22 529507002690 Predicted helix-turn-helix motif with score 1422.000, SD 4.03 at aa 171-192, sequence PPLQELAQYIGASEKTITRLFY 529507002691 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 2.1e-05 529507002692 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 529507002693 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 529507002694 dimer interface [polypeptide binding]; other site 529507002695 active site 529507002696 citrylCoA binding site [chemical binding]; other site 529507002697 NADH binding [chemical binding]; other site 529507002698 cationic pore residues; other site 529507002699 oxalacetate/citrate binding site [chemical binding]; other site 529507002700 coenzyme A binding site [chemical binding]; other site 529507002701 catalytic triad [active] 529507002702 HMMPfam hit to PF00285, Citrate synthase, score 1.7e-232 529507002703 PS00480 Citrate synthase signature. 529507002704 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 529507002705 Iron-sulfur protein interface; other site 529507002706 proximal quinone binding site [chemical binding]; other site 529507002707 SdhD (CybS) interface [polypeptide binding]; other site 529507002708 proximal heme binding site [chemical binding]; other site 529507002709 HMMPfam hit to PF01127, Succinate dehydrogenase cytochrome b subunit, score 3.5e-35 529507002710 PS01000 Succinate dehydrogenase cytochrome b subunit signature 1. 529507002711 3 probable transmembrane helices predicted for PMI0565 by TMHMM2.0 at aa 23-45, 60-82 and 102-124 529507002712 PS01001 Succinate dehydrogenase cytochrome b subunit signature 2. 529507002713 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 529507002714 SdhC subunit interface [polypeptide binding]; other site 529507002715 proximal heme binding site [chemical binding]; other site 529507002716 cardiolipin binding site; other site 529507002717 Iron-sulfur protein interface; other site 529507002718 proximal quinone binding site [chemical binding]; other site 529507002719 3 probable transmembrane helices predicted for PMI0566 by TMHMM2.0 at aa 15-37, 58-80 and 90-112 529507002720 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 529507002721 L-aspartate oxidase; Provisional; Region: PRK06175 529507002722 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 529507002723 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507002724 PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. 529507002725 HMMPfam hit to PF00890, FAD binding domain, score 1.3e-216 529507002726 HMMPfam hit to PF02910, Fumarate reductase/succinate dehydroge, score 1.5e-67 529507002727 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 529507002728 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 529507002729 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 0.022 529507002730 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507002731 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 529507002732 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 529507002733 TPP-binding site [chemical binding]; other site 529507002734 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 529507002735 dimer interface [polypeptide binding]; other site 529507002736 PYR/PP interface [polypeptide binding]; other site 529507002737 TPP binding site [chemical binding]; other site 529507002738 HMMPfam hit to PF00676, Dehydrogenase E1 component, score 1.3e-26 529507002739 HMMPfam hit to PF02779, Transketolase, pyridine binding domain, score 3.7e-70 529507002740 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 529507002741 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 529507002742 E3 interaction surface; other site 529507002743 lipoyl attachment site [posttranslational modification]; other site 529507002744 e3 binding domain; Region: E3_binding; pfam02817 529507002745 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 529507002746 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 3.8e-24 529507002747 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 529507002748 HMMPfam hit to PF02817, e3 binding domain, score 1.9e-14 529507002749 HMMPfam hit to PF00198, 2-oxoacid dehydrogenases acyltransferas, score 7.9e-141 529507002750 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 529507002751 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 529507002752 CoA-ligase; Region: Ligase_CoA; pfam00549 529507002753 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507002754 HMMPfam hit to PF02222, ATP-grasp domain, score 2.7e-27 529507002755 HMMPfam hit to PF00549, CoA-ligase, score 9.2e-82 529507002756 PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3. 529507002757 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 529507002758 CoA binding domain; Region: CoA_binding; smart00881 529507002759 CoA-ligase; Region: Ligase_CoA; pfam00549 529507002760 HMMPfam hit to PF02629, CoA binding domain, score 1.7e-67 529507002761 HMMPfam hit to PF00549, CoA-ligase, score 4.2e-65 529507002762 PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1. 529507002763 PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site. 529507002764 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 529507002765 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 529507002766 HMMPfam hit to PF01654, Bacterial Cytochrome Ubiquinol Oxidase, score 0 529507002767 9 probable transmembrane helices predicted for PMI0573 by TMHMM2.0 at aa 20-42, 54-76, 96-118, 131-150, 185-207, 219-238, 387-409, 421-443 and 466-488 529507002768 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 529507002769 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 529507002770 HMMPfam hit to PF02322, Cytochrome oxidase subunit II, score 2.2e-192 529507002771 8 probable transmembrane helices predicted for PMI0574 by TMHMM2.0 at aa 7-24, 77-99, 123-145, 165-187, 215-237, 269-288, 295-317 and 344-366 529507002772 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507002773 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 529507002774 Signal peptide predicted for PMI0575 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.351 between residues 20 and 21 529507002775 1 probable transmembrane helix predicted for PMI0575 by TMHMM2.0 at aa 2-24 529507002776 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507002777 hypothetical protein; Provisional; Region: PRK10588 529507002778 Signal peptide predicted for PMI0576 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.754 between residues 37 and 38 529507002779 3 probable transmembrane helices predicted for PMI0576 by TMHMM2.0 at aa 13-33, 43-65 and 70-92 529507002780 Transcriptional regulator [Transcription]; Region: LysR; COG0583 529507002781 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507002782 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 529507002783 putative effector binding pocket; other site 529507002784 dimerization interface [polypeptide binding]; other site 529507002785 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.6e-32 529507002786 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.5e-19 529507002787 PS00044 Bacterial regulatory proteins, lysR family signature. 529507002788 Predicted helix-turn-helix motif with score 1665.000, SD 4.86 at aa 18-39, sequence GSFTQAAKYLRLSKSMVSIHIK 529507002789 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 529507002790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507002791 putative substrate translocation pore; other site 529507002792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507002793 putative substrate translocation pore; other site 529507002794 Signal peptide predicted for PMI0578 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 33 and 34 529507002795 14 probable transmembrane helices predicted for PMI0578 by TMHMM2.0 at aa 7-29, 39-61, 68-87, 97-119, 132-154, 159-181, 194-216, 221-238, 259-281, 296-318, 325-343, 353-375, 396-416 and 421-443 529507002796 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 9.8e-57 529507002797 PS00217 Sugar transport proteins signature 2. 529507002798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 529507002799 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 529507002800 active site 529507002801 PS01328 4-hydroxybenzoyl-CoA thioesterase family active site. 529507002802 HMMPfam hit to PF03061, Thioesterase superfamily, score 4.5e-19 529507002803 colicin uptake protein TolQ; Provisional; Region: PRK10801 529507002804 3 probable transmembrane helices predicted for PMI0581 by TMHMM2.0 at aa 13-35, 133-155 and 170-192 529507002805 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 2.3e-62 529507002806 colicin uptake protein TolR; Provisional; Region: PRK11024 529507002807 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 529507002808 Signal peptide predicted for PMI0582 by SignalP 2.0 HMM (Signal peptide probability 0.709) with cleavage site probability 0.264 between residues 41 and 42 529507002809 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 2.3e-15 529507002810 1 probable transmembrane helix predicted for PMI0582 by TMHMM2.0 at aa 17-39 529507002811 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 529507002812 TolA C-terminal; Region: TolA; pfam06519 529507002813 HMMPfam hit to PF06519, TolA protein, score 1.3e-108 529507002814 1 probable transmembrane helix predicted for PMI0583 by TMHMM2.0 at aa 16-38 529507002815 translocation protein TolB; Provisional; Region: tolB; PRK03629 529507002816 TolB amino-terminal domain; Region: TolB_N; pfam04052 529507002817 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 529507002818 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 529507002819 Signal peptide predicted for PMI0584 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.916 between residues 23 and 24 529507002820 HMMPfam hit to PF04052, TolB amino-terminal domain, score 5.5e-70 529507002821 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 0.65 529507002822 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 1.5e-06 529507002823 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 5.1e-09 529507002824 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 0.83 529507002825 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 0.12 529507002826 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 529507002827 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 529507002828 ligand binding site [chemical binding]; other site 529507002829 Signal peptide predicted for PMI0585 by SignalP 2.0 HMM (Signal peptide probability 0.805) with cleavage site probability 0.487 between residues 26 and 27 529507002830 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507002831 HMMPfam hit to PF00691, OmpA family, score 7.4e-50 529507002832 PS01068 OmpA-like domain. 529507002833 tol-pal system protein YbgF; Provisional; Region: PRK10803 529507002834 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 529507002835 TPR motif; other site 529507002836 Signal peptide predicted for PMI0586 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.856 between residues 27 and 28 529507002837 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.026; HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.35 529507002838 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.03; HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.00068 529507002839 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 529507002840 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 529507002841 HMMPfam hit to PF04973, Nicotinamide mononucleotide transport, score 4.8e-58 529507002842 7 probable transmembrane helices predicted for PMI0588 by TMHMM2.0 at aa 23-42, 49-71, 75-92, 113-142, 162-179, 184-203 and 207-229 529507002843 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 529507002844 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 529507002845 HMMPfam hit to PF00793, DAHP synthetase I family, score 3e-172 529507002846 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 529507002847 catalytic core [active] 529507002848 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 529507002849 HMMPfam hit to PF00300, Phosphoglycerate mutase family, score 1.4e-129 529507002850 PS00175 Phosphoglycerate mutase family phosphohistidine signature. 529507002851 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 529507002852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507002853 Walker A/P-loop; other site 529507002854 ATP binding site [chemical binding]; other site 529507002855 Q-loop/lid; other site 529507002856 ABC transporter signature motif; other site 529507002857 Walker B; other site 529507002858 D-loop; other site 529507002859 H-loop/switch region; other site 529507002860 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507002861 Walker A/P-loop; other site 529507002862 ATP binding site [chemical binding]; other site 529507002863 Q-loop/lid; other site 529507002864 ABC transporter signature motif; other site 529507002865 Walker B; other site 529507002866 D-loop; other site 529507002867 H-loop/switch region; other site 529507002868 HMMPfam hit to PF00005, ABC transporter, score 7e-43 529507002869 PS00017 ATP/GTP-binding site motif A (P-loop). 529507002870 HMMPfam hit to PF00005, ABC transporter, score 2.6e-16 529507002871 PS00017 ATP/GTP-binding site motif A (P-loop). 529507002872 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 529507002873 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 529507002874 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 529507002875 Signal peptide predicted for PMI0592 by SignalP 2.0 HMM (Signal peptide probability 0.924) with cleavage site probability 0.919 between residues 29 and 30 529507002876 HMMPfam hit to PF03865, Haemolysin secretion/activation protein ShlB, score 2.5e-12 529507002877 1 probable transmembrane helix predicted for PMI0592 by TMHMM2.0 at aa 9-31 529507002878 haemagglutination activity domain; Region: Haemagg_act; pfam05860 529507002879 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 529507002880 1 probable transmembrane helix predicted for PMI0593 by TMHMM2.0 at aa 12-34 529507002881 HMMPfam hit to PF05860, haemagglutination activity domain, score 2e-46 529507002882 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.0017 529507002883 HMMPfam hit to PF05594, Haemagluttinin repeat, score 5.1 529507002884 HMMPfam hit to PF05594, Haemagluttinin repeat, score 1.1 529507002885 HMMPfam hit to PF04830, Possible hemagglutinin (DUF637), score 1.9e-11 529507002886 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 529507002887 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 529507002888 molybdenum-pterin binding domain; Region: Mop; TIGR00638 529507002889 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 529507002890 HMMPfam hit to PF03459, TOBE domain, score 9.2e-06 529507002891 HMMPfam hit to PF03459, TOBE domain, score 6.4e-16 529507002892 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix protei, score 5.9e-14 529507002893 Predicted helix-turn-helix motif with score 986.000, SD 2.55 at aa 32-53, sequence GSISQGAKMAGISYKSAWDAIN 529507002894 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 529507002895 1 probable transmembrane helix predicted for PMI0596 by TMHMM2.0 at aa 23-45 529507002896 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 529507002897 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 529507002898 Signal peptide predicted for PMI0597 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.970 between residues 24 and 25 529507002899 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 0.00026 529507002900 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 529507002901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507002902 dimer interface [polypeptide binding]; other site 529507002903 conserved gate region; other site 529507002904 putative PBP binding loops; other site 529507002905 ABC-ATPase subunit interface; other site 529507002906 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.9e-26 529507002907 5 probable transmembrane helices predicted for PMI0598 by TMHMM2.0 at aa 20-38, 50-72, 92-114, 135-157 and 199-221 529507002908 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 529507002909 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 529507002910 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507002911 Walker A/P-loop; other site 529507002912 ATP binding site [chemical binding]; other site 529507002913 Q-loop/lid; other site 529507002914 ABC transporter signature motif; other site 529507002915 Walker B; other site 529507002916 D-loop; other site 529507002917 H-loop/switch region; other site 529507002918 TOBE domain; Region: TOBE; cl01440 529507002919 HMMPfam hit to PF00005, ABC transporter, score 3.1e-59 529507002920 PS00017 ATP/GTP-binding site motif A (P-loop). 529507002921 PS00211 ABC transporters family signature. 529507002922 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 529507002923 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 529507002924 active site 529507002925 motif I; other site 529507002926 motif II; other site 529507002927 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 529507002928 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 4.2e-11 529507002929 PS01229 Hypothetical cof family signature 2. 529507002930 6-phosphogluconolactonase; Provisional; Region: PRK11028 529507002931 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 529507002932 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 529507002933 inhibitor-cofactor binding pocket; inhibition site 529507002934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507002935 catalytic residue [active] 529507002936 HMMPfam hit to PF00202, Aminotransferase class-III, score 5.1e-170 529507002937 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 529507002938 biotin synthase; Provisional; Region: PRK15108 529507002939 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 529507002940 FeS/SAM binding site; other site 529507002941 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 529507002942 HMMPfam hit to PF04055, Radical SAM superfamily, score 2.2e-25 529507002943 HMMPfam hit to PF06968, Biotin and Thiamin Synthesis associated d, score 3.5e-53 529507002944 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507002945 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 529507002946 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 529507002947 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 529507002948 catalytic residue [active] 529507002949 PS00414 Profilin signature. 529507002950 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1.1e-34 529507002951 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 529507002952 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 529507002953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507002954 S-adenosylmethionine binding site [chemical binding]; other site 529507002955 AAA domain; Region: AAA_26; pfam13500 529507002956 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 529507002957 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 7.7e-16 529507002958 excinuclease ABC subunit B; Provisional; Region: PRK05298 529507002959 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 529507002960 ATP binding site [chemical binding]; other site 529507002961 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 529507002962 nucleotide binding region [chemical binding]; other site 529507002963 ATP-binding site [chemical binding]; other site 529507002964 Ultra-violet resistance protein B; Region: UvrB; pfam12344 529507002965 UvrB/uvrC motif; Region: UVR; pfam02151 529507002966 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 1.1e-05 529507002967 PS00017 ATP/GTP-binding site motif A (P-loop). 529507002968 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 4.3e-19 529507002969 HMMPfam hit to PF02151, UvrB/uvrC motif, score 5.1e-11 529507002970 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 529507002971 1 probable transmembrane helix predicted for PMI0608 by TMHMM2.0 at aa 4-26 529507002972 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 529507002973 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 529507002974 phosphate binding site [ion binding]; other site 529507002975 putative substrate binding pocket [chemical binding]; other site 529507002976 dimer interface [polypeptide binding]; other site 529507002977 HMMPfam hit to PF01933, Uncharacterised protein family UPF0052, score 9.6e-113 529507002978 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 529507002979 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 529507002980 FeS/SAM binding site; other site 529507002981 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 529507002982 HMMPfam hit to PF04055, Radical SAM superfamily, score 4.4e-39 529507002983 PS01305 moaA / nifB / pqqE family signature. 529507002984 HMMPfam hit to PF06463, Molybdenum Cofactor Synthesis C, score 4.6e-43 529507002985 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 529507002986 trimer interface [polypeptide binding]; other site 529507002987 dimer interface [polypeptide binding]; other site 529507002988 putative active site [active] 529507002989 HMMPfam hit to PF01967, MoaC family, score 3.1e-92 529507002990 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 529507002991 MoaE interaction surface [polypeptide binding]; other site 529507002992 MoeB interaction surface [polypeptide binding]; other site 529507002993 thiocarboxylated glycine; other site 529507002994 HMMPfam hit to PF02597, ThiS family, score 5.3e-24 529507002995 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 529507002996 MoaE homodimer interface [polypeptide binding]; other site 529507002997 MoaD interaction [polypeptide binding]; other site 529507002998 active site residues [active] 529507002999 HMMPfam hit to PF02391, MoaE protein, score 1.5e-55 529507003000 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 529507003001 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 529507003002 HMMPfam hit to PF01027, Uncharacterised protein family UPF0005, score 1.4e-43 529507003003 7 probable transmembrane helices predicted for PMI0614 by TMHMM2.0 at aa 25-47, 54-76, 86-108, 113-135, 140-162, 169-186 and 211-233 529507003004 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 529507003005 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 529507003006 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 529507003007 6 probable transmembrane helices predicted for PMI0615 by TMHMM2.0 at aa 24-43, 174-196, 224-246, 256-278, 285-304 and 343-365 529507003008 HMMPfam hit to PF01061, ABC-2 type transporter, score 1.9e-40 529507003009 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 529507003010 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 529507003011 6 probable transmembrane helices predicted for PMI0616 by TMHMM2.0 at aa 33-55, 189-211, 237-259, 269-291, 298-320 and 355-377 529507003012 HMMPfam hit to PF01061, ABC-2 type transporter, score 8.9e-18 529507003013 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 529507003014 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 529507003015 Walker A/P-loop; other site 529507003016 ATP binding site [chemical binding]; other site 529507003017 Q-loop/lid; other site 529507003018 ABC transporter signature motif; other site 529507003019 Walker B; other site 529507003020 D-loop; other site 529507003021 H-loop/switch region; other site 529507003022 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 529507003023 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 529507003024 Walker A/P-loop; other site 529507003025 ATP binding site [chemical binding]; other site 529507003026 Q-loop/lid; other site 529507003027 ABC transporter signature motif; other site 529507003028 Walker B; other site 529507003029 D-loop; other site 529507003030 H-loop/switch region; other site 529507003031 HMMPfam hit to PF00005, ABC transporter, score 5.2e-52 529507003032 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003033 HMMPfam hit to PF00005, ABC transporter, score 5.3e-48 529507003034 PS00211 ABC transporters family signature. 529507003035 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003036 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 529507003037 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 529507003038 HlyD family secretion protein; Region: HlyD_3; pfam13437 529507003039 HMMPfam hit to PF00529, HlyD family secretion protein, score 5e-18 529507003040 1 probable transmembrane helix predicted for PMI0618 by TMHMM2.0 at aa 7-25 529507003041 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 529507003042 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 529507003043 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 529507003044 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 6.4e-14 529507003045 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 529507003046 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 529507003047 ATP binding site [chemical binding]; other site 529507003048 Mg++ binding site [ion binding]; other site 529507003049 motif III; other site 529507003050 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 529507003051 nucleotide binding region [chemical binding]; other site 529507003052 ATP-binding site [chemical binding]; other site 529507003053 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 3.3e-06 529507003054 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 9.5e-68 529507003055 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003056 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 529507003057 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 7.1e-31 529507003058 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 529507003059 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 529507003060 FMN binding site [chemical binding]; other site 529507003061 active site 529507003062 catalytic residues [active] 529507003063 substrate binding site [chemical binding]; other site 529507003064 HMMPfam hit to PF01207, Dihydrouridine synthase (Dus), score 1.1e-111 529507003065 PS01136 Uncharacterized protein family UPF0034 signature. 529507003066 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 529507003067 3 probable transmembrane helices predicted for PMI0622 by TMHMM2.0 at aa 21-43, 58-80 and 87-109 529507003068 HMMPfam hit to PF04226, Transglycosylase associated protein, score 3.4e-14 529507003069 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 529507003070 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 529507003071 active site residue [active] 529507003072 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 529507003073 active site residue [active] 529507003074 HMMPfam hit to PF00581, Rhodanese-like domain, score 1.6e-24 529507003075 HMMPfam hit to PF00581, Rhodanese-like domain, score 5.5e-18 529507003076 PS00380 Rhodanese signature 1. 529507003077 1 probable transmembrane helix predicted for PMI0624 by TMHMM2.0 at aa 21-43 529507003078 Signal peptide predicted for PMI0624 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.588 between residues 22 and 23 529507003079 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 529507003080 HMMPfam hit to PF03606, C4-dicarboxylate anaerobic carrier, score 1e-65 529507003081 10 probable transmembrane helices predicted for PMI0625 by TMHMM2.0 at aa 36-58, 82-104, 161-183, 210-232, 242-259, 280-298, 313-335, 342-364, 374-396 and 403-422 529507003082 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 529507003083 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 529507003084 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 529507003085 catalytic residue [active] 529507003086 HMMPfam hit to PF01053, Cys/Met metabolism PLP-dependent enzy, score 7e-103 529507003087 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 529507003088 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 529507003089 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 529507003090 tetramer interface [polypeptide binding]; other site 529507003091 active site 529507003092 HMMPfam hit to PF00206, Lyase, score 1.4e-23 529507003093 PS00043 Bacterial regulatory proteins, gntR family signature. 529507003094 PS00163 Fumarate lyases signature. 529507003095 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 529507003096 HMMPfam hit to PF03972, MmgE/PrpD family, score 4.3e-80 529507003097 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 529507003098 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507003099 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 529507003100 putative dimerization interface [polypeptide binding]; other site 529507003101 HMMPfam hit to PF03466, LysR substrate binding domain, score 4.5e-26 529507003102 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.6e-15 529507003103 PS00044 Bacterial regulatory proteins, lysR family signature. 529507003104 Predicted helix-turn-helix motif with score 1340.000, SD 3.75 at aa 26-47, sequence STFAAAAESVCRTQSAVSQQMQ 529507003105 Signal peptide predicted for PMI0629 by SignalP 2.0 HMM (Signal peptide probability 0.625) with cleavage site probability 0.405 between residues 31 and 32 529507003106 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 529507003107 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 529507003108 DEAD_2; Region: DEAD_2; pfam06733 529507003109 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 529507003110 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003111 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 529507003112 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 529507003113 dimerization interface [polypeptide binding]; other site 529507003114 DPS ferroxidase diiron center [ion binding]; other site 529507003115 ion pore; other site 529507003116 HMMPfam hit to PF00210, Ferritin-like domain, score 4.7e-25 529507003117 PS00818 Dps protein family signature 1. 529507003118 threonine and homoserine efflux system; Provisional; Region: PRK10532 529507003119 EamA-like transporter family; Region: EamA; pfam00892 529507003120 10 probable transmembrane helices predicted for PMI0632 by TMHMM2.0 at aa 12-29, 39-61, 68-90, 95-117, 124-141, 151-168, 175-196, 206-228, 241-260 and 265-284 529507003121 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 3.7e-20 529507003122 Signal peptide predicted for PMI0632 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.981 between residues 33 and 34 529507003123 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 529507003124 Signal peptide predicted for PMI0633 by SignalP 2.0 HMM (Signal peptide probability 0.847) with cleavage site probability 0.747 between residues 22 and 23 529507003125 HMMPfam hit to PF03641, Possible lysine decarboxylase, score 7.6e-61 529507003126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 529507003127 Coenzyme A binding pocket [chemical binding]; other site 529507003128 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 7.2e-19 529507003129 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 529507003130 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 529507003131 active site 529507003132 HMMPfam hit to PF01979, Amidohydrolase family, score 0.0051 529507003133 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 529507003134 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 529507003135 ATP binding site [chemical binding]; other site 529507003136 substrate interface [chemical binding]; other site 529507003137 HMMPfam hit to PF05237, MoeZ/MoeB domain, score 1e-38 529507003138 HMMPfam hit to PF00899, ThiF family, score 9.7e-54 529507003139 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507003140 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 529507003141 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 529507003142 dimer interface [polypeptide binding]; other site 529507003143 putative functional site; other site 529507003144 putative MPT binding site; other site 529507003145 HMMPfam hit to PF03454, MoeA C-terminal region (domain IV), score 1.2e-14 529507003146 HMMPfam hit to PF00994, Probable molybdopterin binding domain, score 6.8e-57 529507003147 PS01079 Molybdenum cofactor biosynthesis proteins signature 2. 529507003148 HMMPfam hit to PF03453, MoeA N-terminal region (domain I and II, score 2.6e-72 529507003149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507003150 Major Facilitator Superfamily; Region: MFS_1; pfam07690 529507003151 putative substrate translocation pore; other site 529507003152 12 probable transmembrane helices predicted for PMI0638 by TMHMM2.0 at aa 13-35, 48-65, 78-100, 110-132, 139-161, 171-190, 215-237, 247-269, 276-295, 299-321, 333-355 and 365-382 529507003153 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.1e-17 529507003154 HMMPfam hit to PF06779, Protein of unknown function (DUF1228), score 8.3e-35 529507003155 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 529507003156 active site 529507003157 HMMPfam hit to PF01227, GTP cyclohydrolase I, score 3.6e-56 529507003158 PS00859 GTP cyclohydrolase I signature 1. 529507003159 PS00860 GTP cyclohydrolase I signature 2. 529507003160 hypothetical protein; Provisional; Region: PRK10835 529507003161 Predicted membrane protein [Function unknown]; Region: COG2311 529507003162 HMMPfam hit to PF04171, Protein of unknown function (DUF405), score 7.4e-37 529507003163 10 probable transmembrane helices predicted for PMI0640 by TMHMM2.0 at aa 17-39, 59-81, 88-107, 112-129, 136-158, 206-225, 232-254, 269-291, 304-326 and 341-363 529507003164 HMMPfam hit to PF04235, Protein of unknown function (DUF418), score 1.8e-27 529507003165 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 529507003166 putative active site [active] 529507003167 HMMPfam hit to PF02698, DUF218 domain, score 1.9e-37 529507003168 1 probable transmembrane helix predicted for PMI0641 by TMHMM2.0 at aa 7-29 529507003169 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507003170 Signal peptide predicted for PMI0641 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.908 between residues 22 and 23 529507003171 malate dehydrogenase; Provisional; Region: PRK13529 529507003172 Malic enzyme, N-terminal domain; Region: malic; pfam00390 529507003173 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 529507003174 NAD(P) binding site [chemical binding]; other site 529507003175 HMMPfam hit to PF03949, Malic enzyme, NAD binding domain, score 2.3e-129 529507003176 PS00331 Malic enzymes signature. 529507003177 HMMPfam hit to PF00390, Malic enzyme, N-terminal domain, score 1.9e-123 529507003178 cytidine deaminase; Provisional; Region: PRK09027 529507003179 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 529507003180 active site 529507003181 catalytic motif [active] 529507003182 Zn binding site [ion binding]; other site 529507003183 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 529507003184 active site 529507003185 catalytic motif [active] 529507003186 Zn binding site [ion binding]; other site 529507003187 HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminase, score 8.8e-22 529507003188 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 529507003189 hypothetical protein; Provisional; Region: PRK10711 529507003190 HMMPfam hit to PF04172, LrgB-like family, score 1.3e-115 529507003191 6 probable transmembrane helices predicted for PMI0644 by TMHMM2.0 at aa 4-21, 32-54, 58-80, 93-115, 142-164 and 203-225 529507003192 hypothetical protein; Provisional; Region: PRK01821 529507003193 HMMPfam hit to PF03788, LrgA family, score 3.6e-48 529507003194 4 probable transmembrane helices predicted for PMI0645 by TMHMM2.0 at aa 20-42, 52-74, 81-103 and 107-129 529507003195 Signal peptide predicted for PMI0645 by SignalP 2.0 HMM (Signal peptide probability 0.622) with cleavage site probability 0.305 between residues 43 and 44 529507003196 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 529507003197 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 529507003198 active site 529507003199 HIGH motif; other site 529507003200 KMSKS motif; other site 529507003201 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 529507003202 tRNA binding surface [nucleotide binding]; other site 529507003203 anticodon binding site; other site 529507003204 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 529507003205 dimer interface [polypeptide binding]; other site 529507003206 putative tRNA-binding site [nucleotide binding]; other site 529507003207 HMMPfam hit to PF01588, tRNA binding domain, score 9.1e-40 529507003208 HMMPfam hit to PF00133, tRNA synthetases class I (I, L, M and V), score 2.9e-05 529507003209 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 529507003210 antiporter inner membrane protein; Provisional; Region: PRK11670 529507003211 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 529507003212 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003213 PS01215 Mrp family signature. 529507003214 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 529507003215 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 529507003216 ATP-binding site [chemical binding]; other site 529507003217 Sugar specificity; other site 529507003218 Pyrimidine base specificity; other site 529507003219 HMMPfam hit to PF00485, Phosphoribulokinase / Uridine kinase family, score 2.8e-50 529507003220 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003221 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 529507003222 trimer interface [polypeptide binding]; other site 529507003223 active site 529507003224 HMMPfam hit to PF00692, dUTPase, score 3.6e-28 529507003225 putative assembly protein; Provisional; Region: PRK10833 529507003226 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 529507003227 HMMPfam hit to PF05170, AsmA family, score 8.4e-42 529507003228 Signal peptide predicted for PMI0651 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.329 between residues 25 and 26 529507003229 1 probable transmembrane helix predicted for PMI0651 by TMHMM2.0 at aa 7-26 529507003230 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 529507003231 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 529507003232 11 probable transmembrane helices predicted for PMI0652 by TMHMM2.0 at aa 21-38, 48-70, 91-113, 142-164, 177-199, 219-238, 262-280, 290-312, 333-355, 360-382 and 452-471 529507003233 HMMPfam hit to PF03606, C4-dicarboxylate anaerobic carrier, score 2.4e-196 529507003234 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 529507003235 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 529507003236 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 529507003237 Transporter associated domain; Region: CorC_HlyC; smart01091 529507003238 HMMPfam hit to PF03471, Transporter associated domain, score 5.9e-23 529507003239 HMMPfam hit to PF00571, CBS domain, score 5.4e-09 529507003240 HMMPfam hit to PF00571, CBS domain, score 1.6e-06 529507003241 7 probable transmembrane helices predicted for PMI0653 by TMHMM2.0 at aa 38-60, 73-95, 110-127, 148-170, 175-197, 210-232 and 237-256 529507003242 HMMPfam hit to PF03741, Integral membrane protein TerC family, score 1.3e-74 529507003243 transposase (fragment) 529507003244 HMMPfam hit to PF07282, transposase DNA-binding domai, score 4.7e-34 529507003245 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507003246 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 529507003247 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 529507003248 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 529507003249 HMMPfam hit to PF03446, NAD binding domain of 6-phosphogluconat, score 8.3e-122 529507003250 HMMPfam hit to PF00393, 6-phosphogluconate dehydrogenase, C-ter, score 3.6e-234 529507003251 PS00461 6-phosphogluconate dehydrogenase signature. 529507003252 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 529507003253 putative deacylase active site [active] 529507003254 HMMPfam hit to PF04073, YbaK / prolyl-tRNA synthetases associated do, score 8.6e-37 529507003255 putative alcohol dehydrogenase; Provisional; Region: PRK09860 529507003256 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 529507003257 dimer interface [polypeptide binding]; other site 529507003258 active site 529507003259 metal binding site [ion binding]; metal-binding site 529507003260 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 1.5e-207 529507003261 PS00913 Iron-containing alcohol dehydrogenases signature 1. 529507003262 PS00060 Iron-containing alcohol dehydrogenases signature 2. 529507003263 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 529507003264 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 529507003265 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 529507003266 metal binding site [ion binding]; metal-binding site 529507003267 HMMPfam hit to PF01503, Phosphoribosyl-ATP pyrophosphohydrolase, score 6.6e-46 529507003268 HMMPfam hit to PF01502, Phosphoribosyl-AMP cyclohydrolase, score 8.6e-42 529507003269 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 529507003270 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 529507003271 substrate binding site [chemical binding]; other site 529507003272 glutamase interaction surface [polypeptide binding]; other site 529507003273 HMMPfam hit to PF00977, Histidine biosynthesis protein, score 2.2e-113 529507003274 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 529507003275 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 529507003276 catalytic residues [active] 529507003277 HMMPfam hit to PF00977, Histidine biosynthesis protein, score 4.1e-108 529507003278 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 529507003279 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 529507003280 putative active site [active] 529507003281 oxyanion strand; other site 529507003282 catalytic triad [active] 529507003283 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 6.4e-42 529507003284 PS00442 Glutamine amidotransferases class-I active site. 529507003285 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 529507003286 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 529507003287 active site 529507003288 motif I; other site 529507003289 motif II; other site 529507003290 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 529507003291 putative active site pocket [active] 529507003292 4-fold oligomerization interface [polypeptide binding]; other site 529507003293 metal binding residues [ion binding]; metal-binding site 529507003294 3-fold/trimer interface [polypeptide binding]; other site 529507003295 HMMPfam hit to PF00475, Imidazoleglycerol-phosphate dehydratase, score 2.4e-103 529507003296 PS00955 Imidazoleglycerol-phosphate dehydratase signature 2. 529507003297 PS00954 Imidazoleglycerol-phosphate dehydratase signature 1. 529507003298 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 529507003299 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 529507003300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507003301 homodimer interface [polypeptide binding]; other site 529507003302 catalytic residue [active] 529507003303 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1.6e-58 529507003304 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 529507003305 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 529507003306 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 529507003307 NAD binding site [chemical binding]; other site 529507003308 dimerization interface [polypeptide binding]; other site 529507003309 product binding site; other site 529507003310 substrate binding site [chemical binding]; other site 529507003311 zinc binding site [ion binding]; other site 529507003312 catalytic residues [active] 529507003313 HMMPfam hit to PF00815, Histidinol dehydrogenase, score 9.6e-241 529507003314 PS00611 Histidinol dehydrogenase signature. 529507003315 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 529507003316 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 529507003317 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 529507003318 HMMPfam hit to PF01634, ATP phosphoribosyltransferase, score 4.6e-80 529507003319 PS01316 ATP phosphoribosyltransferase signature. 529507003320 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 529507003321 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 529507003322 putative NAD(P) binding site [chemical binding]; other site 529507003323 Signal peptide predicted for PMI0667 by SignalP 2.0 HMM (Signal peptide probability 0.783) with cleavage site probability 0.394 between residues 19 and 20 529507003324 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 529507003325 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 529507003326 putative C-terminal domain interface [polypeptide binding]; other site 529507003327 putative GSH binding site (G-site) [chemical binding]; other site 529507003328 putative dimer interface [polypeptide binding]; other site 529507003329 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 529507003330 putative N-terminal domain interface [polypeptide binding]; other site 529507003331 putative dimer interface [polypeptide binding]; other site 529507003332 putative substrate binding pocket (H-site) [chemical binding]; other site 529507003333 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal domain, score 3.2e-11 529507003334 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 1.1e-09 529507003335 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 529507003336 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 529507003337 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 529507003338 Signal peptide predicted for PMI0669 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.988 between residues 28 and 29 529507003339 1 probable transmembrane helix predicted for PMI0669 by TMHMM2.0 at aa 7-29 529507003340 HMMPfam hit to PF00768, D-alanyl-D-alanine carboxypeptidase, score 4.5e-135 529507003341 HMMPfam hit to PF07943, Penicillin-binding protein 5, C-termina, score 2.1e-36 529507003342 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 529507003343 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 529507003344 Potassium binding sites [ion binding]; other site 529507003345 Cesium cation binding sites [ion binding]; other site 529507003346 HMMPfam hit to PF01268, Formate--tetrahydrofolate ligase, score 0 529507003347 PS00721 Formate--tetrahydrofolate ligase signature 1. 529507003348 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003349 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 529507003350 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 529507003351 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 529507003352 HMMPfam hit to PF03313, Serine dehydratase alpha chain, score 6e-193 529507003353 HMMPfam hit to PF03315, Serine dehydratase beta chain, score 1.1e-95 529507003354 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 529507003355 serine transporter; Region: stp; TIGR00814 529507003356 11 probable transmembrane helices predicted for PMI0672 by TMHMM2.0 at aa 27-44, 48-70, 101-123, 138-160, 172-194, 214-236, 257-279, 305-327, 356-378, 382-399 and 411-433 529507003357 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 529507003358 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 529507003359 active site 529507003360 HMMPfam hit to PF01569, PAP2 superfamily, score 1.7e-23 529507003361 5 probable transmembrane helices predicted for PMI0673 by TMHMM2.0 at aa 26-48, 60-82, 102-124, 129-146 and 151-173 529507003362 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 529507003363 HMMPfam hit to PF01894, Uncharacterised protein family UPF0047, score 1.4e-46 529507003364 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 529507003365 GSH binding site [chemical binding]; other site 529507003366 catalytic residues [active] 529507003367 HMMPfam hit to PF00462, Glutaredoxin, score 4.5e-28 529507003368 Predicted helix-turn-helix motif with score 1188.000, SD 3.23 at aa 43-64, sequence ITKADLSKTVGKPVETVPQIFI 529507003369 PS00195 Glutaredoxin active site. 529507003370 hypothetical protein; Provisional; Region: PRK10591 529507003371 HMMPfam hit to PF07214, Protein of unknown function (DUF1418), score 5.5e-12 529507003372 2 probable transmembrane helices predicted for PMI0676 by TMHMM2.0 at aa 24-46 and 56-78 529507003373 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 529507003374 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 529507003375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507003376 S-adenosylmethionine binding site [chemical binding]; other site 529507003377 HMMPfam hit to PF05958, tRNA (Uracil-5-)-methyltransferase, score 2.5e-06 529507003378 PS01230 RNA methyltransferase trmA family signature 1. 529507003379 PS01231 RNA methyltransferase trmA family signature 2. 529507003380 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 529507003381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507003382 dimer interface [polypeptide binding]; other site 529507003383 conserved gate region; other site 529507003384 putative PBP binding loops; other site 529507003385 ABC-ATPase subunit interface; other site 529507003386 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 8.5e-16 529507003387 5 probable transmembrane helices predicted for PMI0679 by TMHMM2.0 at aa 15-37, 50-72, 87-109, 155-174 and 189-211 529507003388 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 529507003389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507003390 dimer interface [polypeptide binding]; other site 529507003391 conserved gate region; other site 529507003392 putative PBP binding loops; other site 529507003393 ABC-ATPase subunit interface; other site 529507003394 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.1e-09 529507003395 4 probable transmembrane helices predicted for PMI0680 by TMHMM2.0 at aa 10-32, 53-75, 95-114 and 197-219 529507003396 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 529507003397 Signal peptide predicted for PMI0680 by SignalP 2.0 HMM (Signal peptide probability 0.955) with cleavage site probability 0.859 between residues 29 and 30 529507003398 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 529507003399 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 529507003400 substrate binding pocket [chemical binding]; other site 529507003401 membrane-bound complex binding site; other site 529507003402 hinge residues; other site 529507003403 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 1.1e-95 529507003404 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 529507003405 Signal peptide predicted for PMI0681 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 19 and 20 529507003406 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 529507003407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507003408 Walker A/P-loop; other site 529507003409 ATP binding site [chemical binding]; other site 529507003410 Q-loop/lid; other site 529507003411 ABC transporter signature motif; other site 529507003412 Walker B; other site 529507003413 D-loop; other site 529507003414 H-loop/switch region; other site 529507003415 HMMPfam hit to PF00005, ABC transporter, score 4.9e-65 529507003416 PS00211 ABC transporters family signature. 529507003417 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003418 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 529507003419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 529507003420 NAD(P) binding site [chemical binding]; other site 529507003421 active site 529507003422 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 529507003423 1 probable transmembrane helix predicted for PMI0683 by TMHMM2.0 at aa 439-461 529507003424 Predicted membrane protein [Function unknown]; Region: COG2431 529507003425 HMMPfam hit to PF03956, Membrane protein of unknown function (DUF340, score 5.7e-72 529507003426 8 probable transmembrane helices predicted for PMI0684 by TMHMM2.0 at aa 5-22, 29-51, 61-83, 112-134, 139-156, 169-191, 206-228 and 273-295 529507003427 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 529507003428 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 529507003429 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 529507003430 putative active site [active] 529507003431 putative metal-binding site [ion binding]; other site 529507003432 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003433 macrolide transporter subunit MacA; Provisional; Region: PRK11578 529507003434 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 529507003435 HlyD family secretion protein; Region: HlyD_3; pfam13437 529507003436 1 probable transmembrane helix predicted for PMI0686 by TMHMM2.0 at aa 12-29 529507003437 HMMPfam hit to PF00529, HlyD family secretion protein, score 4.3e-07 529507003438 Predicted helix-turn-helix motif with score 1050.000, SD 2.76 at aa 309-330, sequence VPLSALGENVGINEYQVEVLVN 529507003439 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 529507003440 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 529507003441 Walker A/P-loop; other site 529507003442 ATP binding site [chemical binding]; other site 529507003443 Q-loop/lid; other site 529507003444 ABC transporter signature motif; other site 529507003445 Walker B; other site 529507003446 D-loop; other site 529507003447 H-loop/switch region; other site 529507003448 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 529507003449 FtsX-like permease family; Region: FtsX; pfam02687 529507003450 HMMPfam hit to PF00005, ABC transporter, score 4e-65 529507003451 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003452 PS00211 ABC transporters family signature. 529507003453 4 probable transmembrane helices predicted for PMI0687 by TMHMM2.0 at aa 269-291, 526-548, 571-593 and 608-630 529507003454 HMMPfam hit to PF02687, Predicted permease, score 1.4e-51 529507003455 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507003456 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 529507003457 DNA-binding site [nucleotide binding]; DNA binding site 529507003458 RNA-binding motif; other site 529507003459 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 3.8e-35 529507003460 PS00352 'Cold-shock' DNA-binding domain signature. 529507003461 Uncharacterized conserved protein [Function unknown]; Region: COG2127 529507003462 HMMPfam hit to PF02617, ATP-dependent Clp protease adaptor protein C, score 2.5e-49 529507003463 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 529507003464 Clp amino terminal domain; Region: Clp_N; pfam02861 529507003465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 529507003466 Walker A motif; other site 529507003467 ATP binding site [chemical binding]; other site 529507003468 Walker B motif; other site 529507003469 arginine finger; other site 529507003470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 529507003471 Walker A motif; other site 529507003472 ATP binding site [chemical binding]; other site 529507003473 Walker B motif; other site 529507003474 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 529507003475 HMMPfam hit to PF02861, Clp amino terminal domain, score 1e-14 529507003476 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 2.3e-18 529507003477 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003478 PS00870 Chaperonins clpA/B signature 1. 529507003479 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 1.3e-91 529507003480 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003481 PS00871 Chaperonins clpA/B signature 2. 529507003482 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 529507003483 rRNA binding site [nucleotide binding]; other site 529507003484 predicted 30S ribosome binding site; other site 529507003485 HMMPfam hit to PF00575, S1 RNA binding domain, score 6.6e-11 529507003486 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 529507003487 HMMPfam hit to PF03588, Leucyl/phenylalanyl-tRNA protein transf, score 7.2e-87 529507003488 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 529507003489 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 529507003490 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507003491 Walker A/P-loop; other site 529507003492 ATP binding site [chemical binding]; other site 529507003493 Q-loop/lid; other site 529507003494 ABC transporter signature motif; other site 529507003495 Walker B; other site 529507003496 D-loop; other site 529507003497 H-loop/switch region; other site 529507003498 HMMPfam hit to PF00005, ABC transporter, score 1e-55 529507003499 PS00211 ABC transporters family signature. 529507003500 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003501 6 probable transmembrane helices predicted for PMI0693 by TMHMM2.0 at aa 16-38, 48-70, 133-155, 165-184, 242-264 and 279-301 529507003502 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 0.00049 529507003503 Signal peptide predicted for PMI0693 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.492 between residues 49 and 50 529507003504 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 529507003505 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 529507003506 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507003507 Walker A/P-loop; other site 529507003508 ATP binding site [chemical binding]; other site 529507003509 Q-loop/lid; other site 529507003510 ABC transporter signature motif; other site 529507003511 Walker B; other site 529507003512 D-loop; other site 529507003513 H-loop/switch region; other site 529507003514 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00014 Endoplasmic reticulum targeting sequence. 529507003515 HMMPfam hit to PF00005, ABC transporter, score 1.4e-57 529507003516 PS00211 ABC transporters family signature. 529507003517 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003518 6 probable transmembrane helices predicted for PMI0694 by TMHMM2.0 at aa 42-64, 74-93, 148-170, 174-196, 256-278 and 293-315 529507003519 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 1.1e-29 529507003520 thioredoxin reductase; Provisional; Region: PRK10262 529507003521 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 529507003522 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 529507003523 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreducta, score 4.6e-79 529507003524 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 529507003525 Signal peptide predicted for PMI0695 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.942 between residues 25 and 26 529507003526 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 529507003527 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 529507003528 putative DNA binding site [nucleotide binding]; other site 529507003529 putative Zn2+ binding site [ion binding]; other site 529507003530 AsnC family; Region: AsnC_trans_reg; pfam01037 529507003531 PS00519 Bacterial regulatory proteins, asnC family signature. 529507003532 HMMPfam hit to PF01037, AsnC family, score 4.5e-55 529507003533 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 529507003534 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 529507003535 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 529507003536 5 probable transmembrane helices predicted for PMI0697 by TMHMM2.0 at aa 29-51, 83-105, 118-140, 160-182 and 187-209 529507003537 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507003538 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507003539 HMMPfam hit to PF01580, FtsK/SpoIIIE family, score 1.1e-99 529507003540 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003541 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 529507003542 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 529507003543 Signal peptide predicted for PMI0698 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.972 between residues 21 and 22 529507003544 HMMPfam hit to PF03548, Outer membrane lipoprotein carrier protein L, score 2.9e-88 529507003545 recombination factor protein RarA; Reviewed; Region: PRK13342 529507003546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 529507003547 Walker A motif; other site 529507003548 ATP binding site [chemical binding]; other site 529507003549 Walker B motif; other site 529507003550 arginine finger; other site 529507003551 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 529507003552 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 2.7e-18 529507003553 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003554 seryl-tRNA synthetase; Provisional; Region: PRK05431 529507003555 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 529507003556 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 529507003557 dimer interface [polypeptide binding]; other site 529507003558 active site 529507003559 motif 1; other site 529507003560 motif 2; other site 529507003561 motif 3; other site 529507003562 HMMPfam hit to PF02403, Seryl-tRNA synthetase N-terminal domain, score 2.6e-44 529507003563 HMMPfam hit to PF00587, tRNA synthetase class II core domain (G,, score 1.4e-59 529507003564 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 529507003565 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 529507003566 HMMPfam hit to PF02615, Malate/L-lactate dehydrogenase, score 7.6e-180 529507003567 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 529507003568 6 probable transmembrane helices predicted for PMI0703 by TMHMM2.0 at aa 43-65, 69-91, 120-142, 174-196, 216-235 and 239-261 529507003569 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 529507003570 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 529507003571 FeS/SAM binding site; other site 529507003572 HMMPfam hit to PF04055, Radical SAM superfamily, score 2.6e-28 529507003573 PS01087 Radical activating enzymes signature. 529507003574 PS00190 Cytochrome c family heme-binding site signature. 529507003575 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 529507003576 Pyruvate formate lyase 1; Region: PFL1; cd01678 529507003577 coenzyme A binding site [chemical binding]; other site 529507003578 active site 529507003579 catalytic residues [active] 529507003580 glycine loop; other site 529507003581 HMMPfam hit to PF01228, Glycine radical, score 5.4e-67 529507003582 PS00850 Glycine radical signature. 529507003583 HMMPfam hit to PF02901, Pyruvate formate lyase, score 0 529507003584 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 529507003585 HMMPfam hit to PF01226, Formate/nitrite transporter, score 3.4e-148 529507003586 6 probable transmembrane helices predicted for PMI0706 by TMHMM2.0 at aa 34-56, 76-98, 119-141, 161-183, 195-217 and 255-277 529507003587 PS01006 Formate and nitrite transporters signature 2. 529507003588 PS01005 Formate and nitrite transporters signature 1. 529507003589 uncharacterized domain; Region: TIGR00702 529507003590 YcaO-like family; Region: YcaO; pfam02624 529507003591 HMMPfam hit to PF02624, YcaO-like family, score 3.9e-149 529507003592 L-asparaginase II; Provisional; Region: ansB; PRK11096 529507003593 active site 529507003594 homodimer interface [polypeptide binding]; other site 529507003595 Signal peptide predicted for PMI0708 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 20 and 21 529507003596 1 probable transmembrane helix predicted for PMI0708 by TMHMM2.0 at aa 7-29 529507003597 PS00144 Asparaginase / glutaminase active site signature 1. 529507003598 HMMPfam hit to PF00710, Asparaginase, score 9e-147 529507003599 PS00917 Asparaginase / glutaminase active site signature 2. 529507003600 haemagglutination activity domain; Region: Haemagg_act; pfam05860 529507003601 HMMPfam hit to PF05860, haemagglutination activity domain, score 1.1e-22 529507003602 Signal peptide predicted for PMI0709 by SignalP 2.0 HMM (Signal peptide probability 0.846) with cleavage site probability 0.833 between residues 20 and 21 529507003603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507003604 Major Facilitator Superfamily; Region: MFS_1; pfam07690 529507003605 putative substrate translocation pore; other site 529507003606 14 probable transmembrane helices predicted for PMI0710 by TMHMM2.0 at aa 25-47, 62-84, 91-113, 118-140, 147-169, 179-198, 211-233, 237-256, 268-290, 300-322, 343-365, 370-392, 413-435 and 450-472 529507003607 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 5.2e-35 529507003608 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 529507003609 homodimer interface [polypeptide binding]; other site 529507003610 substrate-cofactor binding pocket; other site 529507003611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507003612 catalytic residue [active] 529507003613 HMMPfam hit to PF00266, Aminotransferase class-V, score 1e-97 529507003614 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 529507003615 1 probable transmembrane helix predicted for PMI0712 by TMHMM2.0 at aa 5-27 529507003616 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 529507003617 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 529507003618 hinge; other site 529507003619 active site 529507003620 HMMPfam hit to PF00275, EPSP synthase (3-phosphoshikimate 1-car, score 1.1e-215 529507003621 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003622 PS00104 EPSP synthase signature 1. 529507003623 PS00885 EPSP synthase signature 2. 529507003624 cytidylate kinase; Provisional; Region: cmk; PRK00023 529507003625 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 529507003626 CMP-binding site; other site 529507003627 The sites determining sugar specificity; other site 529507003628 HMMPfam hit to PF02224, Cytidylate kinase, score 1.5e-81 529507003629 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 529507003630 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 529507003631 RNA binding site [nucleotide binding]; other site 529507003632 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 529507003633 RNA binding site [nucleotide binding]; other site 529507003634 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 529507003635 RNA binding site [nucleotide binding]; other site 529507003636 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 529507003637 RNA binding site [nucleotide binding]; other site 529507003638 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 529507003639 RNA binding site [nucleotide binding]; other site 529507003640 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 529507003641 RNA binding site [nucleotide binding]; other site 529507003642 HMMPfam hit to PF00575, S1 RNA binding domain, score 7.1e-13 529507003643 HMMPfam hit to PF00575, S1 RNA binding domain, score 3.4e-17 529507003644 HMMPfam hit to PF00575, S1 RNA binding domain, score 7.1e-32 529507003645 HMMPfam hit to PF00575, S1 RNA binding domain, score 4e-30 529507003646 HMMPfam hit to PF00575, S1 RNA binding domain, score 4e-25 529507003647 HMMPfam hit to PF00575, S1 RNA binding domain, score 2.1e-21 529507003648 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 529507003649 IHF dimer interface [polypeptide binding]; other site 529507003650 IHF - DNA interface [nucleotide binding]; other site 529507003651 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 2e-47 529507003652 PS00045 Bacterial histone-like DNA-binding proteins signature. 529507003653 ComEC family competence protein; Provisional; Region: PRK11539 529507003654 Competence protein; Region: Competence; pfam03772 529507003655 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 529507003656 10 probable transmembrane helices predicted for PMI0717 by TMHMM2.0 at aa 36-55, 65-87, 257-279, 294-316, 321-343, 358-380, 393-415, 430-452, 469-491 and 506-528 529507003657 HMMPfam hit to PF03772, Competence protein, score 5e-41 529507003658 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 3e-13 529507003659 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 529507003660 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 529507003661 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 529507003662 Walker A/P-loop; other site 529507003663 ATP binding site [chemical binding]; other site 529507003664 Q-loop/lid; other site 529507003665 ABC transporter signature motif; other site 529507003666 Walker B; other site 529507003667 D-loop; other site 529507003668 H-loop/switch region; other site 529507003669 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 7.3e-64 529507003670 5 probable transmembrane helices predicted for PMI0718 by TMHMM2.0 at aa 28-50, 74-96, 142-164, 168-190 and 248-270 529507003671 HMMPfam hit to PF00005, ABC transporter, score 1.1e-65 529507003672 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003673 PS00211 ABC transporters family signature. 529507003674 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 529507003675 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 529507003676 1 probable transmembrane helix predicted for PMI0719 by TMHMM2.0 at aa 12-34 529507003677 HMMPfam hit to PF02606, Tetraacyldisaccharide-1-P 4'-kinase, score 7.6e-132 529507003678 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 529507003679 DNA-binding site [nucleotide binding]; DNA binding site 529507003680 RNA-binding motif; other site 529507003681 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 1.3e-14 529507003682 Trm112p-like protein; Region: Trm112p; cl01066 529507003683 HMMPfam hit to PF03966, Protein of unknown function (DUF343), score 4.5e-18 529507003684 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 529507003685 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 529507003686 Ligand binding site; other site 529507003687 oligomer interface; other site 529507003688 HMMPfam hit to PF02348, Cytidylyltransferase, score 1e-83 529507003689 Uncharacterized conserved protein [Function unknown]; Region: COG1434 529507003690 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 529507003691 putative active site [active] 529507003692 HMMPfam hit to PF02698, DUF218 domain, score 2.7e-33 529507003693 3 probable transmembrane helices predicted for PMI0723 by TMHMM2.0 at aa 9-31, 41-63 and 70-92 529507003694 Methyltransferase domain; Region: Methyltransf_31; pfam13847 529507003695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507003696 S-adenosylmethionine binding site [chemical binding]; other site 529507003697 condesin subunit F; Provisional; Region: PRK05260 529507003698 HMMPfam hit to PF03882, KicB killing factor, score 0 529507003699 PS00430 TonB-dependent receptor proteins signature 1. 529507003700 condesin subunit E; Provisional; Region: PRK05256 529507003701 HMMPfam hit to PF04288, MukE-like family, score 6e-137 529507003702 cell division protein MukB; Provisional; Region: mukB; PRK04863 529507003703 P-loop containing region of AAA domain; Region: AAA_29; cl17516 529507003704 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 529507003705 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 529507003706 HMMPfam hit to PF04310, MukB N-terminal, score 4.3e-170 529507003707 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003708 Predicted helix-turn-helix motif with score 1177.000, SD 3.20 at aa 328-349, sequence TDYQAASDRLNLVQNAVRQQEK 529507003709 chloramphenicol acetyltransferase; Provisional; Region: PRK13757 529507003710 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 529507003711 HMMPfam hit to PF00302, Chloramphenicol acetyltransferase, score 6.5e-154 529507003712 PS00100 Chloramphenicol acetyltransferase active site. 529507003713 acid phosphatase/phosphotransferase; Provisional; Region: aphA; PRK11009 529507003714 HMMPfam hit to PF03767, HAD superfamily, subfamily IIIB (Acid, score 3.4e-38 529507003715 Signal peptide predicted for PMI0729 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.785 between residues 23 and 24 529507003716 murein L,D-transpeptidase; Provisional; Region: PRK10594 529507003717 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 529507003718 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 529507003719 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 529507003720 PS00092 N-6 Adenine-specific DNA methylases signature. 529507003721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 529507003722 Peptidase M15; Region: Peptidase_M15_3; cl01194 529507003723 Signal peptide predicted for PMI0731 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.923 between residues 30 and 31 529507003724 HMMPfam hit to PF05951, Bacterial protein of unknown function (DUF88, score 2.9e-93 529507003725 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 529507003726 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 1.2e-32 529507003727 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 529507003728 HMMPfam hit to PF05638, Protein of unknown function (DUF796), score 5.3e-63 529507003729 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 529507003730 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 529507003731 HMMPfam hit to PF05947, Bacterial protein of unknown function (DUF87, score 3.8e-09 529507003732 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 529507003733 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 529507003734 ImpA domain protein; Region: DUF3702; pfam12486 529507003735 1 probable transmembrane helix predicted for PMI0735 by TMHMM2.0 at aa 235-257 529507003736 HMMPfam hit to PF06812, ImpA-related N-terminal, score 2.3e-21 529507003737 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 529507003738 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 529507003739 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 529507003740 HMMPfam hit to PF06744, Protein of unknown function (DUF1215), score 3e-52 529507003741 HMMPfam hit to PF06761, ImcF-related, score 9.4e-99 529507003742 3 probable transmembrane helices predicted for PMI0736 by TMHMM2.0 at aa 26-48, 63-85 and 459-481 529507003743 Signal peptide predicted for PMI0736 by SignalP 2.0 HMM (Signal peptide probability 0.976) with cleavage site probability 0.396 between residues 53 and 54 529507003744 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 529507003745 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 529507003746 HMMPfam hit to PF06812, ImpA-related N-terminal, score 6.6e-12 529507003747 Protein of unknown function (DUF3121); Region: DUF3121; pfam11319 529507003748 Signal peptide predicted for PMI0738 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.957 between residues 22 and 23 529507003749 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 529507003750 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 529507003751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 529507003752 Walker A motif; other site 529507003753 ATP binding site [chemical binding]; other site 529507003754 Walker B motif; other site 529507003755 arginine finger; other site 529507003756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 529507003757 Walker A motif; other site 529507003758 ATP binding site [chemical binding]; other site 529507003759 Walker B motif; other site 529507003760 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 529507003761 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 7.4e-79 529507003762 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003763 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 1.4e-05 529507003764 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003765 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 529507003766 1 probable transmembrane helix predicted for PMI0741 by TMHMM2.0 at aa 215-237 529507003767 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 529507003768 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 529507003769 HMMPfam hit to PF05936, Bacterial protein of unknown function (DUF87, score 4.5e-206 529507003770 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 529507003771 Signal peptide predicted for PMI0743 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.555 between residues 27 and 28 529507003772 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507003773 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 529507003774 FHA domain; Region: FHA; pfam00498 529507003775 HMMPfam hit to PF00498, FHA domain, score 4.6e-05 529507003776 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 529507003777 HMMPfam hit to PF06996, Protein of unknown function (DUF1305), score 1.4e-101 529507003778 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 529507003779 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 529507003780 HMMPfam hit to PF05947, Bacterial protein of unknown function (DUF87, score 3.7e-114 529507003781 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003782 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 529507003783 HMMPfam hit to PF07025, Protein of unknown function (DUF1316), score 5.3e-30 529507003784 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 529507003785 Protein of unknown function (DUF877); Region: DUF877; pfam05943 529507003786 HMMPfam hit to PF05943, Protein of unknown function (DUF877), score 1.6e-303 529507003787 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507003788 Protein of unknown function (DUF770); Region: DUF770; pfam05591 529507003789 HMMPfam hit to PF05591, Protein of unknown function (DUF770), score 1.1e-82 529507003790 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 529507003791 HMMPfam hit to PF05638, Protein of unknown function (DUF796), score 2.3e-87 529507003792 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 529507003793 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 529507003794 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 529507003795 HMMPfam hit to PF04524, Protein of unknown function, DUF586, score 1.2e-39 529507003796 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 529507003797 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 529507003798 Signal peptide predicted for PMI0754 by SignalP 2.0 HMM (Signal peptide probability 0.964) with cleavage site probability 0.422 between residues 20 and 21 529507003799 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 529507003800 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 529507003801 Transposase IS200 like; Region: Y1_Tnp; pfam01797 529507003802 HMMPfam hit to PF01797, Transposase IS200 like, score 2e-42 529507003803 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 529507003804 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 529507003805 Probable transposase; Region: OrfB_IS605; pfam01385 529507003806 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 529507003807 HMMPfam hit to PF01385, Probable transposase, score 2.7e-131 529507003808 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 529507003809 RHS Repeat; Region: RHS_repeat; pfam05593 529507003810 RHS Repeat; Region: RHS_repeat; pfam05593 529507003811 RHS Repeat; Region: RHS_repeat; cl11982 529507003812 RHS Repeat; Region: RHS_repeat; cl11982 529507003813 HMMPfam hit to PF05593, RHS Repeat, score 0.0036 529507003814 HMMPfam hit to PF05593, RHS Repeat, score 0.014 529507003815 HMMPfam hit to PF05593, RHS Repeat, score 0.00085 529507003816 HMMPfam hit to PF05593, RHS Repeat, score 0.12 529507003817 HMMPfam hit to PF05593, RHS Repeat, score 1.5e-05 529507003818 HMMPfam hit to PF05593, RHS Repeat, score 7.5e-06 529507003819 HMMPfam hit to PF05593, RHS Repeat, score 0.00047 529507003820 HMMPfam hit to PF05593, RHS Repeat, score 0.0001 529507003821 HMMPfam hit to PF05593, RHS Repeat, score 5.4 529507003822 HMMPfam hit to PF05593, RHS Repeat, score 9.5 529507003823 HMMPfam hit to PF05593, RHS Repeat, score 0.13 529507003824 HMMPfam hit to PF05593, RHS Repeat, score 1.2 529507003825 conserved hypothetical protein (fragment);This CDS appears to be truncated at N-terminus relative to database matches. 529507003826 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 529507003827 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 529507003828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507003829 homodimer interface [polypeptide binding]; other site 529507003830 catalytic residue [active] 529507003831 HMMPfam hit to PF00155, Aminotransferase class I and II, score 5.7e-108 529507003832 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 529507003833 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 529507003834 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 529507003835 trimer interface [polypeptide binding]; other site 529507003836 eyelet of channel; other site 529507003837 HMMPfam hit to PF00267, Gram-negative porin, score 2.9e-169 529507003838 Signal peptide predicted for PMI0765 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 22 and 23 529507003839 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 529507003840 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 529507003841 putative dimer interface [polypeptide binding]; other site 529507003842 putative anticodon binding site; other site 529507003843 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 529507003844 homodimer interface [polypeptide binding]; other site 529507003845 motif 1; other site 529507003846 motif 2; other site 529507003847 active site 529507003848 motif 3; other site 529507003849 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 5.2e-164 529507003850 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 529507003851 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 529507003852 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 1.3e-20 529507003853 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 529507003854 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 529507003855 active site 529507003856 HMMPfam hit to PF04095, Nicotinate phosphoribosyltransferase (NAPRTa, score 1.1e-179 529507003857 aminopeptidase N; Provisional; Region: pepN; PRK14015 529507003858 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 529507003859 active site 529507003860 Zn binding site [ion binding]; other site 529507003861 HMMPfam hit to PF01433, Peptidase family M1, score 4.7e-69 529507003862 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 529507003863 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 529507003864 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 529507003865 HMMPfam hit to PF06250, Protein of unknown function (DUF1016), score 2.8e-141 529507003866 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 529507003867 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 529507003868 quinone interaction residues [chemical binding]; other site 529507003869 active site 529507003870 catalytic residues [active] 529507003871 FMN binding site [chemical binding]; other site 529507003872 substrate binding site [chemical binding]; other site 529507003873 HMMPfam hit to PF01180, Dihydroorotate dehydrogenase, score 2.2e-154 529507003874 PS00911 Dihydroorotate dehydrogenase signature 1. 529507003875 PS00912 Dihydroorotate dehydrogenase signature 2. 529507003876 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 529507003877 HMMPfam hit to PF07126, Protein of unknown function (DUF1379), score 6.5e-71 529507003878 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 529507003879 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 529507003880 MOSC domain; Region: MOSC; pfam03473 529507003881 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 529507003882 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 529507003883 catalytic loop [active] 529507003884 iron binding site [ion binding]; other site 529507003885 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 4.2e-16 529507003886 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 529507003887 HMMPfam hit to PF03473, MOSC domain, score 1.3e-41 529507003888 HMMPfam hit to PF03476, MOSC N-terminal beta barrel domain, score 2.5e-34 529507003889 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 529507003890 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 529507003891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 529507003892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507003893 S-adenosylmethionine binding site [chemical binding]; other site 529507003894 HMMPfam hit to PF02926, THUMP domain, score 2e-13 529507003895 HMMPfam hit to PF01170, RNA methylase family UPF0020, score 7.5e-85 529507003896 PS01261 Uncharacterized protein family UPF0020 signature. 529507003897 PS00092 N-6 Adenine-specific DNA methylases signature. 529507003898 ABC transporter ATPase component; Reviewed; Region: PRK11147 529507003899 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507003900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507003901 Walker A/P-loop; other site 529507003902 Walker A/P-loop; other site 529507003903 ATP binding site [chemical binding]; other site 529507003904 ATP binding site [chemical binding]; other site 529507003905 Q-loop/lid; other site 529507003906 Q-loop/lid; other site 529507003907 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 529507003908 ABC transporter signature motif; other site 529507003909 Walker B; other site 529507003910 D-loop; other site 529507003911 ABC transporter; Region: ABC_tran_2; pfam12848 529507003912 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 529507003913 HMMPfam hit to PF00005, ABC transporter, score 1.3e-42 529507003914 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003915 PS00211 ABC transporters family signature. 529507003916 HMMPfam hit to PF00005, ABC transporter, score 1.2e-38 529507003917 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003918 PS00211 ABC transporters family signature. 529507003919 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 529507003920 Paraquat-inducible protein A; Region: PqiA; pfam04403 529507003921 Paraquat-inducible protein A; Region: PqiA; pfam04403 529507003922 HMMPfam hit to PF04403, Paraquat-inducible protein A, score 7.3e-64 529507003923 8 probable transmembrane helices predicted for PMI0776 by TMHMM2.0 at aa 62-81, 109-131, 148-170, 174-193, 264-286, 315-337, 360-382 and 387-409 529507003924 HMMPfam hit to PF04403, Paraquat-inducible protein A, score 2.2e-82 529507003925 paraquat-inducible protein B; Provisional; Region: PRK10807 529507003926 mce related protein; Region: MCE; pfam02470 529507003927 mce related protein; Region: MCE; pfam02470 529507003928 mce related protein; Region: MCE; pfam02470 529507003929 1 probable transmembrane helix predicted for PMI0777 by TMHMM2.0 at aa 20-42 529507003930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 529507003931 Protein of unknown function (DUF330); Region: DUF330; pfam03886 529507003932 Signal peptide predicted for PMI0778 by SignalP 2.0 HMM (Signal peptide probability 0.928) with cleavage site probability 0.827 between residues 22 and 23 529507003933 HMMPfam hit to PF03886, Protein of unknown function (DUF330), score 3.8e-40 529507003934 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507003935 conserved hypothetical protein (pseudogene);This CDS appears to have a frameshift mutation. 529507003936 Ribosome modulation factor; Region: RMF; pfam04957 529507003937 HMMPfam hit to PF04957, Ribosome modulation factor, score 7.1e-27 529507003938 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 529507003939 active site 1 [active] 529507003940 dimer interface [polypeptide binding]; other site 529507003941 active site 2 [active] 529507003942 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 529507003943 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 529507003944 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 529507003945 HMMPfam hit to PF06303, Protein of unknown function (DUF1047), score 1.4e-102 529507003946 outer membrane protein A; Reviewed; Region: PRK10808 529507003947 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 529507003948 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 529507003949 ligand binding site [chemical binding]; other site 529507003950 HMMPfam hit to PF00691, OmpA family, score 1e-39 529507003951 PS01068 OmpA-like domain. 529507003952 HMMPfam hit to PF01389, OmpA-like transmembrane domain, score 2e-100 529507003953 1 probable transmembrane helix predicted for PMI0785 by TMHMM2.0 at aa 12-29 529507003954 Signal peptide predicted for PMI0785 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 21 and 22 529507003955 SOS cell division inhibitor; Provisional; Region: PRK10595 529507003956 HMMPfam hit to PF03846, Cell division inhibitor SulA, score 3.4e-34 529507003957 TfoX N-terminal domain; Region: TfoX_N; pfam04993 529507003958 TfoX C-terminal domain; Region: TfoX_C; pfam04994 529507003959 HMMPfam hit to PF04993, TfoX N-terminal domain, score 4.9e-12 529507003960 HMMPfam hit to PF04994, TfoX C-terminal domain, score 1.7e-21 529507003961 TIGR01666 family membrane protein; Region: YCCS 529507003962 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 529507003963 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 529507003964 HMMPfam hit to PF05976, Bacterial membrane protein of unknown functi, score 0 529507003965 Predicted helix-turn-helix motif with score 987.000, SD 2.55 at aa 604-625, sequence TSQEEAFKLLCLNHTLLSYISA 529507003966 10 probable transmembrane helices predicted for PMI0788 by TMHMM2.0 at aa 15-37, 67-86, 90-112, 117-139, 144-166, 392-414, 419-436, 443-465, 485-505 and 512-534 529507003967 DNA helicase IV; Provisional; Region: helD; PRK11054 529507003968 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 529507003969 Part of AAA domain; Region: AAA_19; pfam13245 529507003970 Family description; Region: UvrD_C_2; pfam13538 529507003971 HMMPfam hit to PF00580, UvrD/REP helicase, score 1.3e-16 529507003972 PS00017 ATP/GTP-binding site motif A (P-loop). 529507003973 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 529507003974 active site 529507003975 dimer interfaces [polypeptide binding]; other site 529507003976 catalytic residues [active] 529507003977 HMMPfam hit to PF02142, MGS-like domain, score 3.4e-25 529507003978 PS01335 Methylglyoxal synthase active site. 529507003979 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 529507003980 HMMPfam hit to PF02629, CoA binding domain, score 7.7e-21 529507003981 heat shock protein HspQ; Provisional; Region: PRK14129 529507003982 Acylphosphatase; Region: Acylphosphatase; pfam00708 529507003983 HMMPfam hit to PF00708, Acylphosphatase, score 4.8e-07 529507003984 PS00150 Acylphosphatase signature 1. 529507003985 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 529507003986 DsrC like protein; Region: DsrC; pfam04358 529507003987 HMMPfam hit to PF04358, DsrC like protein, score 9.6e-73 529507003988 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 529507003989 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 529507003990 Coenzyme A binding pocket [chemical binding]; other site 529507003991 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 7.7e-15 529507003992 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 529507003993 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 529507003994 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 529507003995 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 529507003996 HSP70 interaction site [polypeptide binding]; other site 529507003997 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 529507003998 substrate binding site [polypeptide binding]; other site 529507003999 dimer interface [polypeptide binding]; other site 529507004000 HMMPfam hit to PF00226, DnaJ domain, score 1.7e-32 529507004001 PS00636 Nt-dnaJ domain signature. 529507004002 HMMPfam hit to PF01556, DnaJ C terminal region, score 4.2e-30 529507004003 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 529507004004 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 529507004005 Transcriptional regulator [Transcription]; Region: LysR; COG0583 529507004006 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507004007 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 529507004008 dimerization interface [polypeptide binding]; other site 529507004009 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 3.4e-19 529507004010 Predicted helix-turn-helix motif with score 1137.000, SD 3.06 at aa 18-39, sequence GSFTRAAEKLALANSAVSRTVK 529507004011 PS00044 Bacterial regulatory proteins, lysR family signature. 529507004012 HMMPfam hit to PF03466, LysR substrate binding domain, score 3.5e-43 529507004013 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 529507004014 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 529507004015 active site 529507004016 catalytic tetrad [active] 529507004017 HMMPfam hit to PF00248, Aldo/keto reductase family, score 9.9e-86 529507004018 PS00062 Aldo/keto reductase family signature 2. 529507004019 PS00798 Aldo/keto reductase family signature 1. 529507004020 Peptidase family C69; Region: Peptidase_C69; cl17793 529507004021 Signal peptide predicted for PMI0803 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.868 between residues 27 and 28 529507004022 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507004023 HMMPfam hit to PF03577, Peptidase family U34, score 7.6e-151 529507004024 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 529507004025 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 529507004026 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 529507004027 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 529507004028 HMMPfam hit to PF06445, Bacterial transcription activator, effect, score 2.2e-09 529507004029 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pro, score 2.4e-11 529507004030 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pro, score 9.2e-12 529507004031 Predicted helix-turn-helix motif with score 1036.000, SD 2.72 at aa 26-47, sequence LSLDIIAEKSGYTKWHFQRLFK 529507004032 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 529507004033 Signal peptide predicted for PMI0805 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.988 between residues 23 and 24 529507004034 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 529507004035 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 0.00011 529507004036 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 529507004037 DNA-binding site [nucleotide binding]; DNA binding site 529507004038 RNA-binding motif; other site 529507004039 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 7.2e-44 529507004040 PS00352 'Cold-shock' DNA-binding domain signature. 529507004041 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 529507004042 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 529507004043 putative acyl-acceptor binding pocket; other site 529507004044 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltr, score 1.4e-87 529507004045 1 probable transmembrane helix predicted for PMI0808 by TMHMM2.0 at aa 17-39 529507004046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507004047 S-adenosylmethionine binding site [chemical binding]; other site 529507004048 Signal peptide predicted for PMI0810 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 25 and 26 529507004049 Methyltransferase domain; Region: Methyltransf_31; pfam13847 529507004050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507004051 S-adenosylmethionine binding site [chemical binding]; other site 529507004052 2 probable transmembrane helices predicted for PMI0813 by TMHMM2.0 at aa 10-29 and 57-79 529507004053 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507004054 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 529507004055 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 529507004056 two-component response regulator (pseudogene);This CDS contains a frameshift mutation. 529507004057 1 probable transmembrane helix predicted for PMI0816 by TMHMM2.0 at aa 2-19 529507004058 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 529507004059 HMMPfam hit to PF03681, Uncharacterised protein family (UPF0150), score 7.4e-14 529507004060 YcfA-like protein; Region: YcfA; pfam07927 529507004061 HMMPfam hit to PF07927, YcfA-like protein, score 7.4e-22 529507004062 phage portal protein (pseudogene);This CDS contains a frameshift mutation. 529507004063 phage-related protein (pseudogene);This CDS contains a frameshift mutation. 529507004064 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 529507004065 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 529507004066 Sulfatase; Region: Sulfatase; cl17466 529507004067 HMMPfam hit to PF00884, Sulfatase, score 1.9e-09 529507004068 5 probable transmembrane helices predicted for PMI0823 by TMHMM2.0 at aa 21-40, 60-82, 89-111, 135-157 and 168-190 529507004069 hypothetical protein; Provisional; Region: PRK13689 529507004070 HMMPfam hit to PF07208, Protein of unknown function (DUF1414), score 1.4e-44 529507004071 Nucleoid-associated protein [General function prediction only]; Region: COG3081 529507004072 nucleoid-associated protein NdpA; Validated; Region: PRK00378 529507004073 HMMPfam hit to PF04245, 37-kD nucleoid-associated bacterial protein, score 5.7e-179 529507004074 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 529507004075 5S rRNA interface [nucleotide binding]; other site 529507004076 CTC domain interface [polypeptide binding]; other site 529507004077 L16 interface [polypeptide binding]; other site 529507004078 HMMPfam hit to PF01386, Ribosomal L25p family, score 8.3e-36 529507004079 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 529507004080 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 529507004081 ATP binding site [chemical binding]; other site 529507004082 putative Mg++ binding site [ion binding]; other site 529507004083 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 529507004084 nucleotide binding region [chemical binding]; other site 529507004085 ATP-binding site [chemical binding]; other site 529507004086 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.5e-09 529507004087 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 1.4e-13 529507004088 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 6.9e-35 529507004089 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 529507004090 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 529507004091 RNA binding surface [nucleotide binding]; other site 529507004092 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 529507004093 active site 529507004094 uracil binding [chemical binding]; other site 529507004095 HMMPfam hit to PF01479, S4 domain, score 2.1e-08 529507004096 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 2.4e-21 529507004097 PS01149 Rsu family of pseudouridine synthase signature. 529507004098 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 529507004099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507004100 putative substrate translocation pore; other site 529507004101 HMMPfam hit to PF00083, Sugar (and other) transporter, score 0.00016 529507004102 12 probable transmembrane helices predicted for PMI0829 by TMHMM2.0 at aa 13-35, 55-74, 81-100, 106-128, 141-163, 168-190, 224-246, 256-278, 285-307, 312-334, 347-369 and 373-395 529507004103 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.7e-55 529507004104 hypothetical protein; Provisional; Region: PRK11835 529507004105 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 529507004106 NlpC/P60 family; Region: NLPC_P60; pfam00877 529507004107 HMMPfam hit to PF00877, NlpC/P60 family, score 2.5e-46 529507004108 Signal peptide predicted for PMI0831 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.547 between residues 35 and 36 529507004109 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507004110 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 529507004111 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 529507004112 active site 529507004113 HMMPfam hit to PF01569, PAP2 superfamily, score 1e-06 529507004114 5 probable transmembrane helices predicted for PMI0832 by TMHMM2.0 at aa 12-31, 60-82, 95-114, 164-186 and 199-216 529507004115 Signal peptide predicted for PMI0832 by SignalP 2.0 HMM (Signal peptide probability 0.765) with cleavage site probability 0.298 between residues 31 and 32 529507004116 Signal peptide predicted for PMI0833 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 21 and 22 529507004117 Signal peptide predicted for PMI0834 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.638 between residues 22 and 23 529507004118 elongation factor P; Provisional; Region: PRK04542 529507004119 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 529507004120 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 529507004121 RNA binding site [nucleotide binding]; other site 529507004122 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 529507004123 RNA binding site [nucleotide binding]; other site 529507004124 HMMPfam hit to PF01132, Elongation factor P (EF-P), score 5.8e-95 529507004125 PS01275 Elongation factor P signature. 529507004126 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 529507004127 aromatic amino acid transport protein; Region: araaP; TIGR00837 529507004128 11 probable transmembrane helices predicted for PMI0836 by TMHMM2.0 at aa 13-35, 45-67, 87-109, 124-143, 150-172, 192-214, 227-246, 287-309, 322-339, 343-365 and 385-404 529507004129 HMMPfam hit to PF03222, Tryptophan/tyrosine permease family, score 5.8e-195 529507004130 Signal peptide predicted for PMI0836 by SignalP 2.0 HMM (Signal peptide probability 0.887) with cleavage site probability 0.613 between residues 26 and 27 529507004131 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 529507004132 nudix motif; other site 529507004133 HMMPfam hit to PF00293, NUDIX domain, score 5.5e-29 529507004134 PS00893 mutT domain signature. 529507004135 endonuclease IV; Provisional; Region: PRK01060 529507004136 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 529507004137 AP (apurinic/apyrimidinic) site pocket; other site 529507004138 DNA interaction; other site 529507004139 Metal-binding active site; metal-binding site 529507004140 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 2.6e-64 529507004141 PS00730 AP endonucleases family 2 signature 2. 529507004142 PS00729 AP endonucleases family 2 signature 1. 529507004143 Predicted membrane protein [Function unknown]; Region: COG2855 529507004144 9 probable transmembrane helices predicted for PMI0839 by TMHMM2.0 at aa 45-67, 77-99, 134-156, 166-185, 197-219, 269-286, 307-329, 334-356 and 363-385 529507004145 HMMPfam hit to PF03601, Conserved hypothetical protein, score 2.6e-151 529507004146 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 529507004147 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507004148 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 529507004149 putative dimerization interface [polypeptide binding]; other site 529507004150 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.5e-18 529507004151 Predicted helix-turn-helix motif with score 1175.000, SD 3.19 at aa 20-41, sequence GSTTQASQQLALSQSAVSASLT 529507004152 PS00044 Bacterial regulatory proteins, lysR family signature. 529507004153 HMMPfam hit to PF03466, LysR substrate binding domain, score 1e-56 529507004154 lysine transporter; Provisional; Region: PRK10836 529507004155 Signal peptide predicted for PMI0841 by SignalP 2.0 HMM (Signal peptide probability 0.707) with cleavage site probability 0.519 between residues 52 and 53 529507004156 HMMPfam hit to PF00324, Amino acid permease, score 6e-195 529507004157 12 probable transmembrane helices predicted for PMI0841 by TMHMM2.0 at aa 27-49, 59-81, 109-131, 136-158, 165-187, 202-224, 251-273, 297-319, 349-371, 375-397, 418-440 and 450-472 529507004158 PS00218 amino acid permeases signature. 529507004159 putative outer membrane receptor; Provisional; Region: PRK13513 529507004160 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 529507004161 N-terminal plug; other site 529507004162 ligand-binding site [chemical binding]; other site 529507004163 Signal peptide predicted for PMI0842 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.932 between residues 27 and 28 529507004164 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 8.1e-29 529507004165 Mutant D6_33 529507004166 HMMPfam hit to PF00593, TonB dependent receptor, score 8e-28 529507004167 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 529507004168 12 probable transmembrane helices predicted for PMI0843 by TMHMM2.0 at aa 26-44, 59-81, 102-124, 139-161, 166-188, 208-225, 246-268, 295-317, 345-364, 369-391, 403-420 and 430-447 529507004169 HMMPfam hit to PF00324, Amino acid permease, score 1.9e-13 529507004170 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 529507004171 active site 529507004172 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 529507004173 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 529507004174 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 529507004175 Autotransporter beta-domain; Region: Autotransporter; smart00869 529507004176 HMMPfam hit to PF03797, Autotransporter beta-domain, score 6.8e-32 529507004177 Signal peptide predicted for PMI0844 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.997 between residues 27 and 28 529507004178 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 529507004179 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 529507004180 dimer interface [polypeptide binding]; other site 529507004181 PYR/PP interface [polypeptide binding]; other site 529507004182 TPP binding site [chemical binding]; other site 529507004183 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 529507004184 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 529507004185 TPP-binding site [chemical binding]; other site 529507004186 dimer interface [polypeptide binding]; other site 529507004187 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 1.8e-11 529507004188 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 4.2e-53 529507004189 Transcriptional regulator [Transcription]; Region: LysR; COG0583 529507004190 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507004191 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 529507004192 dimerization interface [polypeptide binding]; other site 529507004193 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.7e-17 529507004194 Predicted helix-turn-helix motif with score 1426.000, SD 4.04 at aa 16-37, sequence NGFSRAADALFITQPAISRSIK 529507004195 PS00044 Bacterial regulatory proteins, lysR family signature. 529507004196 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.4e-41 529507004197 D-lactate dehydrogenase; Provisional; Region: PRK11183 529507004198 FAD binding domain; Region: FAD_binding_4; pfam01565 529507004199 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 529507004200 HMMPfam hit to PF01565, FAD binding domain, score 6.1e-12 529507004201 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 529507004202 exonuclease I; Provisional; Region: sbcB; PRK11779 529507004203 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 529507004204 active site 529507004205 catalytic site [active] 529507004206 substrate binding site [chemical binding]; other site 529507004207 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 529507004208 HMMPfam hit to PF00929, Exonuclease, score 3.5e-27 529507004209 galactoside permease; Reviewed; Region: lacY; PRK09528 529507004210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507004211 putative substrate translocation pore; other site 529507004212 Signal peptide predicted for PMI0850 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.557 between residues 28 and 29 529507004213 HMMPfam hit to PF01306, LacY proton/sugar symporter, score 4.5e-141 529507004214 10 probable transmembrane helices predicted for PMI0850 by TMHMM2.0 at aa 12-34, 44-66, 75-97, 102-124, 167-186, 219-236, 257-279, 308-330, 342-364 and 374-396 529507004215 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.5e-13 529507004216 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 529507004217 hypothetical protein; Provisional; Region: PRK05423 529507004218 HMMPfam hit to PF04363, Protein of unknown function (DUF496), score 1.8e-64 529507004219 ribonuclease E; Reviewed; Region: rne; PRK10811 529507004220 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 529507004221 homodimer interface [polypeptide binding]; other site 529507004222 oligonucleotide binding site [chemical binding]; other site 529507004223 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 529507004224 PS00152 ATP synthase alpha and beta subunits signature. 529507004225 HMMPfam hit to PF00575, S1 RNA binding domain, score 4.5e-20 529507004226 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 529507004227 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 529507004228 RNA binding surface [nucleotide binding]; other site 529507004229 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 529507004230 active site 529507004231 HMMPfam hit to PF01479, S4 domain, score 2.8e-10 529507004232 Predicted helix-turn-helix motif with score 982.000, SD 2.53 at aa 21-42, sequence IDNFLLARLKGVPKSMIYRIIR 529507004233 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 7.7e-56 529507004234 PS01129 Rlu family of pseudouridine synthase signature. 529507004235 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507004236 Signal peptide predicted for PMI0854 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.890 between residues 19 and 20 529507004237 Maf-like protein; Region: Maf; pfam02545 529507004238 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 529507004239 active site 529507004240 dimer interface [polypeptide binding]; other site 529507004241 HMMPfam hit to PF02545, Maf-like protein, score 8e-61 529507004242 hypothetical protein; Provisional; Region: PRK11193 529507004243 HMMPfam hit to PF02620, Uncharacterized ACR, COG1399, score 2.1e-49 529507004244 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 529507004245 HMMPfam hit to PF01783, Ribosomal L32p protein family, score 1.3e-23 529507004246 putative phosphate acyltransferase; Provisional; Region: PRK05331 529507004247 HMMPfam hit to PF02504, Fatty acid synthesis protein, score 1.6e-152 529507004248 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 529507004249 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 529507004250 dimer interface [polypeptide binding]; other site 529507004251 active site 529507004252 CoA binding pocket [chemical binding]; other site 529507004253 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 529507004254 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 529507004255 HMMPfam hit to PF00698, Acyl transferase domain, score 4.6e-14 529507004256 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 529507004257 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 529507004258 NAD(P) binding site [chemical binding]; other site 529507004259 homotetramer interface [polypeptide binding]; other site 529507004260 homodimer interface [polypeptide binding]; other site 529507004261 active site 529507004262 HMMPfam hit to PF00106, short chain dehydrogenase, score 6e-94 529507004263 PS00061 Short-chain dehydrogenases/reductases family signature. 529507004264 acyl carrier protein; Provisional; Region: acpP; PRK00982 529507004265 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 4.8e-22 529507004266 PS00012 Phosphopantetheine attachment site. 529507004267 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 529507004268 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 529507004269 dimer interface [polypeptide binding]; other site 529507004270 active site 529507004271 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 1.2e-70 529507004272 PS00606 Beta-ketoacyl synthases active site. 529507004273 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 1.1e-71 529507004274 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 529507004275 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 529507004276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507004277 catalytic residue [active] 529507004278 HMMPfam hit to PF01063, Aminotransferase class IV, score 2.3e-30 529507004279 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 529507004280 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 529507004281 dimerization interface [polypeptide binding]; other site 529507004282 Signal peptide predicted for PMI0865 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.844 between residues 20 and 21 529507004283 1 probable transmembrane helix predicted for PMI0865 by TMHMM2.0 at aa 7-29 529507004284 HMMPfam hit to PF02618, Aminodeoxychorismate lyase, score 2.2e-140 529507004285 thymidylate kinase; Validated; Region: tmk; PRK00698 529507004286 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 529507004287 TMP-binding site; other site 529507004288 ATP-binding site [chemical binding]; other site 529507004289 HMMPfam hit to PF02223, Thymidylate kinase, score 3.1e-82 529507004290 PS00017 ATP/GTP-binding site motif A (P-loop). 529507004291 PS01331 Thymidylate kinase signature. 529507004292 DNA polymerase III subunit delta'; Validated; Region: PRK07993 529507004293 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 529507004294 PS00190 Cytochrome c family heme-binding site signature. 529507004295 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 529507004296 active site 529507004297 HMMPfam hit to PF01026, TatD related DNase, score 1.4e-121 529507004298 PS01137 Uncharacterized protein family UPF0006 signature 1. 529507004299 PS01090 Uncharacterized protein family UPF0006 signature 2. 529507004300 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 529507004301 nucleotide binding site/active site [active] 529507004302 HIT family signature motif; other site 529507004303 catalytic residue [active] 529507004304 HMMPfam hit to PF01230, HIT domain, score 5.7e-54 529507004305 PS00892 HIT family signature. 529507004306 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 529507004307 putative dimer interface [polypeptide binding]; other site 529507004308 Signal peptide predicted for PMI0870 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 29 and 30 529507004309 1 probable transmembrane helix predicted for PMI0870 by TMHMM2.0 at aa 7-29 529507004310 HMMPfam hit to PF07233, Protein of unknown function (DUF1425), score 1e-23 529507004311 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507004312 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 529507004313 Signal peptide predicted for PMI0871 by SignalP 2.0 HMM (Signal peptide probability 0.918) with cleavage site probability 0.534 between residues 23 and 24 529507004314 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507004315 thiamine kinase; Region: ycfN_thiK; TIGR02721 529507004316 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 529507004317 active site 529507004318 substrate binding site [chemical binding]; other site 529507004319 ATP binding site [chemical binding]; other site 529507004320 HMMPfam hit to PF01636, Phosphotransferase enzyme family, score 5.7e-10 529507004321 HMMPfam hit to PF01633, Choline/ethanolamine kinase, score 5.3e-07 529507004322 beta-hexosaminidase; Provisional; Region: PRK05337 529507004323 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 529507004324 HMMPfam hit to PF00933, Glycosyl hydrolase family 3 N terminal, score 1.2e-80 529507004325 PS00775 Glycosyl hydrolases family 3 active site. 529507004326 hypothetical protein; Provisional; Region: PRK04940 529507004327 HMMPfam hit to PF05728, Uncharacterised protein family (UPF0227), score 7e-85 529507004328 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 529507004329 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 529507004330 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreducta, score 2.3e-47 529507004331 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 529507004332 Signal peptide predicted for PMI0876 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.523 between residues 35 and 36 529507004333 transcription-repair coupling factor; Provisional; Region: PRK10689 529507004334 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 529507004335 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 529507004336 ATP binding site [chemical binding]; other site 529507004337 putative Mg++ binding site [ion binding]; other site 529507004338 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 529507004339 nucleotide binding region [chemical binding]; other site 529507004340 ATP-binding site [chemical binding]; other site 529507004341 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 529507004342 HMMPfam hit to PF03461, TRCF domain, score 5.5e-46 529507004343 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 2e-19 529507004344 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 5.6e-39 529507004345 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 1.9e-07 529507004346 PS00017 ATP/GTP-binding site motif A (P-loop). 529507004347 HMMPfam hit to PF02559, CarD-like/TRCF domain, score 4e-50 529507004348 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 529507004349 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 529507004350 FtsX-like permease family; Region: FtsX; pfam02687 529507004351 4 probable transmembrane helices predicted for PMI0878 by TMHMM2.0 at aa 25-47, 268-290, 311-333 and 367-389 529507004352 HMMPfam hit to PF02687, Predicted permease, score 2.6e-37 529507004353 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 529507004354 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 529507004355 Walker A/P-loop; other site 529507004356 ATP binding site [chemical binding]; other site 529507004357 Q-loop/lid; other site 529507004358 ABC transporter signature motif; other site 529507004359 Walker B; other site 529507004360 D-loop; other site 529507004361 H-loop/switch region; other site 529507004362 HMMPfam hit to PF00005, ABC transporter, score 2.7e-56 529507004363 PS00017 ATP/GTP-binding site motif A (P-loop). 529507004364 PS00211 ABC transporters family signature. 529507004365 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 529507004366 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 529507004367 FtsX-like permease family; Region: FtsX; pfam02687 529507004368 4 probable transmembrane helices predicted for PMI0880 by TMHMM2.0 at aa 21-43, 271-293, 319-341 and 376-398 529507004369 HMMPfam hit to PF02687, Predicted permease, score 3.2e-46 529507004370 NAD-dependent deacetylase; Provisional; Region: PRK00481 529507004371 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 529507004372 NAD+ binding site [chemical binding]; other site 529507004373 substrate binding site [chemical binding]; other site 529507004374 Zn binding site [ion binding]; other site 529507004375 Signal peptide predicted for PMI0881 by SignalP 2.0 HMM (Signal peptide probability 0.746) with cleavage site probability 0.386 between residues 57 and 58 529507004376 HMMPfam hit to PF02146, Sir2 family, score 9.8e-77 529507004377 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 529507004378 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 529507004379 metal binding site [ion binding]; metal-binding site 529507004380 dimer interface [polypeptide binding]; other site 529507004381 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 529507004382 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 529507004383 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 2e-27 529507004384 Uncharacterized conserved protein [Function unknown]; Region: COG2850 529507004385 sensor protein PhoQ; Provisional; Region: PRK10815 529507004386 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 529507004387 HAMP domain; Region: HAMP; pfam00672 529507004388 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 529507004389 dimer interface [polypeptide binding]; other site 529507004390 phosphorylation site [posttranslational modification] 529507004391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 529507004392 ATP binding site [chemical binding]; other site 529507004393 Mg2+ binding site [ion binding]; other site 529507004394 G-X-G motif; other site 529507004395 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.3e-29 529507004396 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 0.00064 529507004397 HMMPfam hit to PF00672, HAMP domain, score 0.0017 529507004398 2 probable transmembrane helices predicted for PMI0884 by TMHMM2.0 at aa 20-42 and 193-215 529507004399 Signal peptide predicted for PMI0884 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.312 between residues 33 and 34 529507004400 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 529507004401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507004402 active site 529507004403 phosphorylation site [posttranslational modification] 529507004404 intermolecular recognition site; other site 529507004405 dimerization interface [polypeptide binding]; other site 529507004406 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 529507004407 DNA binding site [nucleotide binding] 529507004408 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 1.2e-20 529507004409 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.4e-35 529507004410 adenylosuccinate lyase; Provisional; Region: PRK09285 529507004411 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 529507004412 tetramer interface [polypeptide binding]; other site 529507004413 active site 529507004414 HMMPfam hit to PF00206, Lyase, score 8.8e-100 529507004415 PS00163 Fumarate lyases signature. 529507004416 putative lysogenization regulator; Reviewed; Region: PRK00218 529507004417 HMMPfam hit to PF04356, Protein of unknown function (DUF489), score 5.2e-68 529507004418 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 529507004419 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 529507004420 HMMPfam hit to PF03054, tRNA methyl transferase, score 1.6e-232 529507004421 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 529507004422 nudix motif; other site 529507004423 HMMPfam hit to PF00293, NUDIX domain, score 1.7e-21 529507004424 PS00893 mutT domain signature. 529507004425 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 529507004426 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 529507004427 active site 529507004428 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 1.2e-25 529507004429 PS01149 Rsu family of pseudouridine synthase signature. 529507004430 isocitrate dehydrogenase; Validated; Region: PRK07362 529507004431 isocitrate dehydrogenase; Reviewed; Region: PRK07006 529507004432 HMMPfam hit to PF00180, Isocitrate/isopropylmalate dehydrogenase, score 4.8e-160 529507004433 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 529507004434 prophage 529507004435 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 529507004436 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 529507004437 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 529507004438 dimer interface [polypeptide binding]; other site 529507004439 active site 529507004440 Int/Topo IB signature motif; other site 529507004441 HMMPfam hit to PF00589, Phage integrase family, score 4.9e-07 529507004442 Excisionase-like protein; Region: Exc; pfam07825 529507004443 Methyltransferase domain; Region: Methyltransf_25; pfam13649 529507004444 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 529507004445 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 529507004446 dimer interface [polypeptide binding]; other site 529507004447 ssDNA binding site [nucleotide binding]; other site 529507004448 tetramer (dimer of dimers) interface [polypeptide binding]; other site 529507004449 HMMPfam hit to PF00436, Single-strand binding protein family, score 2.2e-36 529507004450 PS00736 Single-strand binding protein family signature 2. 529507004451 PS00735 Single-strand binding protein family signature 1. 529507004452 Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065 529507004453 PS00044 Bacterial regulatory proteins, lysR family signature. 529507004454 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 529507004455 Predicted helix-turn-helix motif with score 1749.000, SD 5.14 at aa 25-46, sequence KSKTEIARHFNVKLPSIYDWIK 529507004456 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507004457 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 529507004458 sequence-specific DNA binding site [nucleotide binding]; other site 529507004459 salt bridge; other site 529507004460 Predicted helix-turn-helix motif with score 2527.000, SD 7.79 at aa 18-39, sequence GGQSEMAKRLGISPPTVNQWIN 529507004461 1 probable transmembrane helix predicted for PMI0905 by TMHMM2.0 at aa 154-176 529507004462 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 529507004463 HMMPfam hit to PF04492, Bacteriophage replication protein O, score 9.5e-07 529507004464 PS00017 ATP/GTP-binding site motif A (P-loop). 529507004465 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 529507004466 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 529507004467 Protein of unknown function (DUF968); Region: DUF968; pfam06147 529507004468 HMMPfam hit to PF06914, Protein of unknown function (DUF1277), score 7.4e-96 529507004469 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 529507004470 HMMPfam hit to PF06530, Phage antitermination protein Q, score 6.4e-51 529507004471 PS00340 Growth factor and cytokines receptors family signature 2. 529507004472 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 529507004473 DNA-binding site [nucleotide binding]; DNA binding site 529507004474 RNA-binding motif; other site 529507004475 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 3.4e-40 529507004476 PS00352 'Cold-shock' DNA-binding domain signature. 529507004477 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507004478 AAA domain; Region: AAA_13; pfam13166 529507004479 Walker A/P-loop; other site 529507004480 ATP binding site [chemical binding]; other site 529507004481 PS00017 ATP/GTP-binding site motif A (P-loop). 529507004482 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 529507004483 HMMPfam hit to PF02627, Carboxymuconolactone decarboxylase family, score 2.2e-23 529507004484 Cupin; Region: Cupin_6; pfam12852 529507004485 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 529507004486 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 529507004487 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.00018 529507004488 Predicted helix-turn-helix motif with score 1074.000, SD 2.84 at aa 220-241, sequence WTLDSLANVASMSRATFVRQFK 529507004489 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 2.1e-10 529507004490 Oligosaccharyl transferase STT3 subunit; Region: STT3; pfam02516 529507004491 1 probable transmembrane helix predicted for PMI0919 by TMHMM2.0 at aa 27-49 529507004492 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 529507004493 catalytic residues [active] 529507004494 Signal peptide predicted for PMI0920 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.736 between residues 24 and 25 529507004495 1 probable transmembrane helix predicted for PMI0920 by TMHMM2.0 at aa 7-29 529507004496 HMMPfam hit to PF00959, Phage lysozyme, score 6.1e-34 529507004497 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 529507004498 HMMPfam hit to PF03245, Bacteriophage lysis protein, score 1.7e-15 529507004499 1 probable transmembrane helix predicted for PMI0921 by TMHMM2.0 at aa 6-25 529507004500 Herpesvirus UL46 protein; Region: Herpes_UL46; cl17368 529507004501 Phage terminase, small subunit; Region: Terminase_4; pfam05119 529507004502 HMMPfam hit to PF05119, Phage terminase, small subunit, score 2.8e-27 529507004503 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 529507004504 HMMPfam hit to PF03354, Phage Terminase, score 1.1e-90 529507004505 Phage-related protein [Function unknown]; Region: COG4695 529507004506 Phage portal protein; Region: Phage_portal; pfam04860 529507004507 HMMPfam hit to PF04860, Phage portal protein, score 7.1e-113 529507004508 Predicted helix-turn-helix motif with score 995.000, SD 2.58 at aa 316-337, sequence IEQQNLGFLQYTLQPYISRWEN 529507004509 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 529507004510 HMMPfam hit to PF04586, Caudovirus prohead protease, score 2.7e-48 529507004511 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 529507004512 Phage capsid family; Region: Phage_capsid; pfam05065 529507004513 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 529507004514 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 529507004515 HMMPfam hit to PF06264, Protein of unknown function (DUF1026), score 2e-27 529507004516 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 529507004517 HMMPfam hit to PF07772, TP901-1 ORF40-like protein, score 2.8e-14 529507004518 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 529507004519 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 529507004520 1 probable transmembrane helix predicted for PMI0935 by TMHMM2.0 at aa 21-43 529507004521 tape measure domain; Region: tape_meas_nterm; TIGR02675 529507004522 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 529507004523 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 529507004524 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 529507004525 Predicted helix-turn-helix motif with score 1203.000, SD 3.28 at aa 136-567, sequence QRFADNADRLGLSQQKVAELTETVSKAVAISGASATAAQAALTQFGQALASGQLRGE ELNSVMEQTPALAKAIADGMGASVGELRKKAQDGEMTIEKVIQALERAADSVDKKFA TSVTTVSQGFTNLQSAMTKFIGEANQGTGATQLLTIGMATLADNLSLVAKVVEGIAV TALVAKLSQWTKATYLKNQATLNEAKATLQSAEANSVAATSAVRKAWADKEAATSAL NRAKMEYQVARGTNAEKIALDNLIATKSLARTASLNYTQALTAENVAQRALTTARRQ STVAGRALNSVMGFAGGPIGLVLTGVAALGMGLYEYSENVKQAKLESIEFANSLDTS TEALNKMSNATLVANLSKVSSGINAQLEKVEELKQQVISLQGLSKYSVESEKAFAEQ GVGDLYLKRVAEKQKELDAAMGIYAEQVNNLER 529507004526 Predicted helix-turn-helix motif with score 1203.000, SD 3.28 at aa 136-157, sequence QRFADNADRLGLSQQKVAELTE 529507004527 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 529507004528 Predicted helix-turn-helix motif with score 1203.000, SD 3.28 at aa 546-567, sequence EKQKELDAAMGIYAEQVNNLER 529507004529 2 probable transmembrane helices predicted for PMI0940 by TMHMM2.0 at aa 5-27 and 32-54 529507004530 Putative phage tail protein; Region: Phage-tail_3; pfam13550 529507004531 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 529507004532 Interdomain contacts; other site 529507004533 Cytokine receptor motif; other site 529507004534 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 529507004535 HMMPfam hit to PF00041, Fibronectin type III domain, score 0.011 529507004536 Cloacin immunity protein; Region: Cloacin_immun; pfam03513 529507004537 HMMPfam hit to PF03513, Cloacin immunity protein, score 6.4e-26 529507004538 2 probable transmembrane helices predicted for PMI0945 by TMHMM2.0 at aa 20-42 and 59-81 529507004539 phage integrase (fragment) 529507004540 isocitrate dehydrogenase (fragment);Similar to the C-terminus of Escherichia coli icd isocitrate dehydrogenase. The CDS encoding this protein lies at the left-end of the prophage. This partial CDS is part of a repeat sequence that was probably generated by the prophage insertion 529507004541 AAA domain; Region: AAA_21; pfam13304 529507004542 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507004543 ABC transporter signature motif; other site 529507004544 Walker B; other site 529507004545 D-loop; other site 529507004546 H-loop/switch region; other site 529507004547 PS00017 ATP/GTP-binding site motif A (P-loop). 529507004548 isocitrate dehydrogenase [NADP] (fragment);Similar to the N-terminus of Escherichia coli icd isocitrate dehydrogenase. This partial CDS is part of a repeat sequence that was probably generated by the prophage insertion 529507004549 prophage 529507004550 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 529507004551 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 529507004552 dimer interface [polypeptide binding]; other site 529507004553 active site 529507004554 Int/Topo IB signature motif; other site 529507004555 HMMPfam hit to PF00589, Phage integrase family, score 4.6e-07 529507004556 Excisionase-like protein; Region: Exc; pfam07825 529507004557 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507004558 non-specific DNA binding site [nucleotide binding]; other site 529507004559 salt bridge; other site 529507004560 sequence-specific DNA binding site [nucleotide binding]; other site 529507004561 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 529507004562 Catalytic site [active] 529507004563 HMMPfam hit to PF00717, Peptidase S24-like, score 0.00059 529507004564 HMMPfam hit to PF01381, Helix-turn-helix, score 5.5e-17 529507004565 Predicted helix-turn-helix motif with score 1997.000, SD 5.99 at aa 18-39, sequence LTQEALAKMLSVSRVSITKWET 529507004566 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752 529507004567 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 529507004568 HMMPfam hit to PF06530, Phage antitermination protein Q, score 1.2e-54 529507004569 PS00228 Tubulin-beta mRNA autoregulation signal. 529507004570 Predicted helix-turn-helix motif with score 1869.000, SD 5.55 at aa 80-101, sequence CSKRSIARRWKVSESRVRQIIQ 529507004571 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507004572 sequence-specific DNA binding site [nucleotide binding]; other site 529507004573 salt bridge; other site 529507004574 Predicted helix-turn-helix motif with score 999.000, SD 2.59 at aa 15-36, sequence LTQEELGILAGIDEESAKIRVC 529507004575 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507004576 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 529507004577 non-specific DNA binding site [nucleotide binding]; other site 529507004578 salt bridge; other site 529507004579 sequence-specific DNA binding site [nucleotide binding]; other site 529507004580 HMMPfam hit to PF01381, Helix-turn-helix, score 2.2e-09 529507004581 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 529507004582 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00014 Endoplasmic reticulum targeting sequence. 529507004583 Predicted helix-turn-helix motif with score 1866.000, SD 5.54 at aa 20-41, sequence TTLAEVSRAAGLSSSTLSNALS 529507004584 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 529507004585 DNA methylase; Region: N6_N4_Mtase; pfam01555 529507004586 DNA methylase; Region: N6_N4_Mtase; pfam01555 529507004587 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 529507004588 PS00092 N-6 Adenine-specific DNA methylases signature. 529507004589 HMMPfam hit to PF01555, DNA methylase, score 2.2e-31 529507004590 Signal peptide predicted for PMI0964 by SignalP 2.0 HMM (Signal peptide probability 0.689) with cleavage site probability 0.285 between residues 32 and 33 529507004591 4 probable transmembrane helices predicted for PMI0964 by TMHMM2.0 at aa 46-68, 83-105, 128-150 and 160-182 529507004592 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 529507004593 HMMPfam hit to PF03245, Bacteriophage lysis protein, score 8.4e-14 529507004594 1 probable transmembrane helix predicted for PMI0965 by TMHMM2.0 at aa 18-35 529507004595 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 529507004596 isocitrate dehydrogenase [NADP] (fragment);Similar to the C-terminus of Escherichia coli isocitrate dehydrogenase Icd . This partial CDS is part of a repeat sequence that was probably generated by the insertion of a prophage 529507004597 This region is deleted from the repeat at the left end of this prophage 529507004598 transposase (fragment) 529507004599 Signal peptide predicted for PMI0970 by SignalP 2.0 HMM (Signal peptide probability 0.980) with cleavage site probability 0.974 between residues 47 and 48 529507004600 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 529507004601 Secretory lipase; Region: LIP; pfam03583 529507004602 HMMPfam hit to PF03583, Secretory lipase, score 8.9e-06 529507004603 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 529507004604 DNA-binding site [nucleotide binding]; DNA binding site 529507004605 RNA-binding motif; other site 529507004606 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 4.4e-39 529507004607 PS00352 'Cold-shock' DNA-binding domain signature. 529507004608 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 529507004609 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 529507004610 HMMPfam hit to PF00011, Hsp20/alpha crystallin family, score 6.1e-13 529507004611 Signal peptide predicted for PMI0974 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.856 between residues 29 and 30 529507004612 4 probable transmembrane helices predicted for PMI0974 by TMHMM2.0 at aa 7-29, 49-71, 78-97 and 117-139 529507004613 Predicted transcriptional regulators [Transcription]; Region: COG1733 529507004614 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 529507004615 HMMPfam hit to PF01638, Transcriptional regulator, score 8.3e-45 529507004616 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 529507004617 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 529507004618 NADP binding site [chemical binding]; other site 529507004619 Signal peptide predicted for PMI0977 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.656 between residues 22 and 23 529507004620 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507004621 hypothetical protein; Provisional; Region: PRK08233 529507004622 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 529507004623 active site 529507004624 Signal peptide predicted for PMI0980 by SignalP 2.0 HMM (Signal peptide probability 0.943) with cleavage site probability 0.596 between residues 32 and 33 529507004625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507004626 non-specific DNA binding site [nucleotide binding]; other site 529507004627 salt bridge; other site 529507004628 sequence-specific DNA binding site [nucleotide binding]; other site 529507004629 HMMPfam hit to PF01381, Helix-turn-helix, score 3.2e-10 529507004630 Predicted helix-turn-helix motif with score 1361.000, SD 3.82 at aa 21-42, sequence LTGIEMGNRLGISQQHYSRIEN 529507004631 2 probable transmembrane helices predicted for PMI0983 by TMHMM2.0 at aa 7-29 and 64-81 529507004632 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 529507004633 ParB-like nuclease domain; Region: ParBc; pfam02195 529507004634 Predicted helix-turn-helix motif with score 1108.000, SD 2.96 at aa 174-195, sequence WNDQKIGDELGMSQDEVLRLKQ 529507004635 HMMPfam hit to PF02195, ParB-like nuclease domain, score 1.2e-05 529507004636 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 529507004637 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 529507004638 Active Sites [active] 529507004639 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 529507004640 Predicted helix-turn-helix motif with score 1077.000, SD 2.86 at aa 233-254, sequence NPIYDLMHQAGVSLSQMRICEP 529507004641 Methyltransferase domain; Region: Methyltransf_31; pfam13847 529507004642 Methyltransferase domain; Region: Methyltransf_12; pfam08242 529507004643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 529507004644 HMMPfam hit to PF04237, Protein of unknown function (DUF419), score 2.2e-25 529507004645 Protein of unknown function (DUF523); Region: DUF523; pfam04463 529507004646 Uncharacterized conserved protein [Function unknown]; Region: COG3272 529507004647 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 529507004648 HMMPfam hit to PF04463, Protein of unknown function (DUF523), score 1e-41 529507004649 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 529507004650 mobilization protein (fragment) 529507004651 Protein of unknown function (DUF465); Region: DUF465; cl01070 529507004652 HMMPfam hit to PF04325, Protein of unknown function (DUF465), score 3.5e-15 529507004653 Signal peptide predicted for PMI0992 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.841 between residues 19 and 20 529507004654 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507004655 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507004656 Predicted ATPase [General function prediction only]; Region: COG3911 529507004657 AAA domain; Region: AAA_28; pfam13521 529507004658 PS00017 ATP/GTP-binding site motif A (P-loop). 529507004659 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 529507004660 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 529507004661 active site 529507004662 HMMPfam hit to PF00557, metallopeptidase family M24, score 2.1e-84 529507004663 PS00680 Methionine aminopeptidase subfamily 1 signature. 529507004664 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 529507004665 HMMPfam hit to PF06530, Phage antitermination protein Q, score 7.3e-22 529507004666 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 529507004667 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 0.0021 529507004668 Predicted helix-turn-helix motif with score 1320.000, SD 3.68 at aa 93-114, sequence TKKADLARKMNLNSAQIERLLD 529507004669 Transposase IS200 like; Region: Y1_Tnp; pfam01797 529507004670 HMMPfam hit to PF01797, Transposase IS200 like, score 1.6e-44 529507004671 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507004672 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 529507004673 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 529507004674 Probable transposase; Region: OrfB_IS605; pfam01385 529507004675 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 529507004676 HMMPfam hit to PF01385, Probable transposase, score 2.7e-131 529507004677 HMMPfam hit to PF07282, transposase DNA-binding domai, score 5.8e-35 529507004678 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507004679 putative hydrolase; Validated; Region: PRK09248 529507004680 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 529507004681 active site 529507004682 HMMPfam hit to PF02231, PHP domain N-terminal region, score 2.6e-17 529507004683 HMMPfam hit to PF02811, PHP domain C-terminal region, score 0.00022 529507004684 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 529507004685 putative active site [active] 529507004686 putative metal binding residues [ion binding]; other site 529507004687 signature motif; other site 529507004688 putative triphosphate binding site [ion binding]; other site 529507004689 dimer interface [polypeptide binding]; other site 529507004690 HMMPfam hit to PF01928, CYTH domain, score 3.8e-17 529507004691 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 529507004692 3 probable transmembrane helices predicted for PMI1005 by TMHMM2.0 at aa 41-63, 70-89 and 93-115 529507004693 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 529507004694 Ligand Binding Site [chemical binding]; other site 529507004695 HMMPfam hit to PF00582, Universal stress protein family, score 1.8e-11 529507004696 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 529507004697 Ferritin-like domain; Region: Ferritin; pfam00210 529507004698 ferroxidase diiron center [ion binding]; other site 529507004699 HMMPfam hit to PF00210, Ferritin-like domain, score 6.5e-48 529507004700 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 529507004701 HMMPfam hit to PF04234, Copper resistance protein CopC, score 9.2e-32 529507004702 Signal peptide predicted for PMI1008 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.817 between residues 30 and 31 529507004703 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507004704 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 529507004705 HMMPfam hit to PF05425, Copper resistance protein D, score 3.5e-40 529507004706 8 probable transmembrane helices predicted for PMI1009 by TMHMM2.0 at aa 10-32, 44-66, 94-111, 118-140, 155-177, 198-220, 238-260 and 273-295 529507004707 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507004708 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 529507004709 Signal peptide predicted for PMI1010 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 19 and 20 529507004710 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 529507004711 HMMPfam hit to PF07351, Protein of unknown function (DUF1480), score 8.1e-23 529507004712 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 529507004713 mce related protein; Region: MCE; pfam02470 529507004714 mce related protein; Region: MCE; pfam02470 529507004715 mce related protein; Region: MCE; pfam02470 529507004716 mce related protein; Region: MCE; pfam02470 529507004717 mce related protein; Region: MCE; pfam02470 529507004718 1 probable transmembrane helix predicted for PMI1012 by TMHMM2.0 at aa 21-43 529507004719 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 529507004720 Paraquat-inducible protein A; Region: PqiA; pfam04403 529507004721 Paraquat-inducible protein A; Region: PqiA; pfam04403 529507004722 HMMPfam hit to PF04403, Paraquat-inducible protein A, score 1.1e-85 529507004723 8 probable transmembrane helices predicted for PMI1013 by TMHMM2.0 at aa 48-70, 101-123, 136-158, 168-190, 248-270, 295-317, 338-360 and 375-397 529507004724 HMMPfam hit to PF04403, Paraquat-inducible protein A, score 8.6e-61 529507004725 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 529507004726 GAF domain; Region: GAF_2; pfam13185 529507004727 PS01320 Uncharacterized protein family UPF0067 signature. 529507004728 ProP expression regulator; Provisional; Region: PRK04950 529507004729 ProQ/FINO family; Region: ProQ; pfam04352 529507004730 HMMPfam hit to PF04352, ProQ activator of osmoprotectant transporter, score 9.9e-78 529507004731 carboxy-terminal protease; Provisional; Region: PRK11186 529507004732 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 529507004733 protein binding site [polypeptide binding]; other site 529507004734 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 529507004735 Catalytic dyad [active] 529507004736 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 529507004737 Signal peptide predicted for PMI1016 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.700 between residues 23 and 24 529507004738 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 2e-16 529507004739 HMMPfam hit to PF03572, Peptidase family S41, score 7.3e-66 529507004740 outer membrane porin, OprD family; Region: OprD; pfam03573 529507004741 Signal peptide predicted for PMI1017 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.770 between residues 23 and 24 529507004742 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 529507004743 heat shock protein HtpX; Provisional; Region: PRK05457 529507004744 HMMPfam hit to PF06509, HtpX N-terminus, score 5.6e-48 529507004745 Signal peptide predicted for PMI1018 by SignalP 2.0 HMM (Signal peptide probability 0.925) with cleavage site probability 0.184 between residues 63 and 64 529507004746 4 probable transmembrane helices predicted for PMI1018 by TMHMM2.0 at aa 5-27, 32-54, 157-179 and 194-216 529507004747 HMMPfam hit to PF01435, Peptidase family M48, score 1.2e-43 529507004748 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 529507004749 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 529507004750 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 1.4e-110 529507004751 9 probable transmembrane helices predicted for PMI1019 by TMHMM2.0 at aa 5-22, 34-51, 71-93, 105-127, 179-201, 232-254, 264-286, 369-391 and 395-417 529507004752 Signal peptide predicted for PMI1019 by SignalP 2.0 HMM (Signal peptide probability 0.656) with cleavage site probability 0.234 between residues 25 and 26 529507004753 inner membrane protein; Provisional; Region: PRK11648 529507004754 3 probable transmembrane helices predicted for PMI1020 by TMHMM2.0 at aa 76-98, 108-130 and 150-172 529507004755 HMMPfam hit to PF04307, Predicted membrane-bound metal-dependent hyd, score 6.6e-27 529507004756 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 529507004757 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 529507004758 motif II; other site 529507004759 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 8.8e-34 529507004760 YniB-like protein; Region: YniB; pfam14002 529507004761 3 probable transmembrane helices predicted for PMI1022 by TMHMM2.0 at aa 24-46, 96-118 and 161-183 529507004762 Phosphotransferase enzyme family; Region: APH; pfam01636 529507004763 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 529507004764 active site 529507004765 substrate binding site [chemical binding]; other site 529507004766 ATP binding site [chemical binding]; other site 529507004767 HMMPfam hit to PF03881, Fructosamine kinase, score 2.5e-139 529507004768 HMMPfam hit to PF01636, Phosphotransferase enzyme family, score 1.1e-18 529507004769 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 529507004770 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 529507004771 ABC-ATPase subunit interface; other site 529507004772 dimer interface [polypeptide binding]; other site 529507004773 putative PBP binding regions; other site 529507004774 8 probable transmembrane helices predicted for PMI1024 by TMHMM2.0 at aa 21-40, 55-77, 97-116, 131-153, 170-192, 196-218, 225-244 and 254-271 529507004775 HMMPfam hit to PF00950, ABC 3 transport family, score 4.2e-127 529507004776 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507004777 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 529507004778 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 529507004779 ABC-ATPase subunit interface; other site 529507004780 dimer interface [polypeptide binding]; other site 529507004781 putative PBP binding regions; other site 529507004782 7 probable transmembrane helices predicted for PMI1025 by TMHMM2.0 at aa 15-37, 58-80, 95-117, 138-160, 178-200, 221-243 and 248-267 529507004783 HMMPfam hit to PF00950, ABC 3 transport family, score 9.7e-127 529507004784 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 529507004785 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 529507004786 HMMPfam hit to PF00005, ABC transporter, score 2e-46 529507004787 PS00211 ABC transporters family signature. 529507004788 PS00017 ATP/GTP-binding site motif A (P-loop). 529507004789 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 529507004790 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 529507004791 metal binding site [ion binding]; metal-binding site 529507004792 HMMPfam hit to PF01297, Periplasmic solute binding protein family, score 2.4e-143 529507004793 Signal peptide predicted for PMI1027 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 29 and 30 529507004794 1 probable transmembrane helix predicted for PMI1027 by TMHMM2.0 at aa 7-29 529507004795 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 529507004796 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 529507004797 N-acetyl-D-glucosamine binding site [chemical binding]; other site 529507004798 catalytic residue [active] 529507004799 Signal peptide predicted for PMI1028 by SignalP 2.0 HMM (Signal peptide probability 0.952) with cleavage site probability 0.608 between residues 25 and 26 529507004800 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507004801 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 3e-29 529507004802 PS00922 Prokaryotic transglycosylases signature. 529507004803 inner membrane protein; Provisional; Region: PRK10995 529507004804 5 probable transmembrane helices predicted for PMI1029 by TMHMM2.0 at aa 13-32, 37-59, 86-108, 118-140 and 161-183 529507004805 HMMPfam hit to PF01914, MarC family integral membrane protein, score 7.4e-49 529507004806 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 529507004807 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 529507004808 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 3.1e-06 529507004809 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 529507004810 dimer interface [polypeptide binding]; other site 529507004811 putative tRNA-binding site [nucleotide binding]; other site 529507004812 HMMPfam hit to PF01588, tRNA binding domain, score 4.2e-17 529507004813 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 529507004814 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 529507004815 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.00068 529507004816 Predicted helix-turn-helix motif with score 1618.000, SD 4.70 at aa 145-166, sequence LTASDIAGALNISISTLQRKVK 529507004817 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 8.2e-11 529507004818 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 529507004819 mannosyl binding site [chemical binding]; other site 529507004820 Fimbrial protein; Region: Fimbrial; pfam00419 529507004821 Signal peptide predicted for PMI1033 by SignalP 2.0 HMM (Signal peptide probability 0.908) with cleavage site probability 0.601 between residues 20 and 21 529507004822 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507004823 HMMPfam hit to PF00419, Fimbrial protein, score 0.0024 529507004824 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 529507004825 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 529507004826 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 529507004827 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 529507004828 active site 529507004829 dimer interface [polypeptide binding]; other site 529507004830 motif 1; other site 529507004831 motif 2; other site 529507004832 motif 3; other site 529507004833 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 529507004834 anticodon binding site; other site 529507004835 HMMPfam hit to PF02824, TGS domain, score 1.6e-11 529507004836 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 3.8e-58 529507004837 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 529507004838 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 529507004839 HMMPfam hit to PF03129, Anticodon binding domain, score 7.1e-33 529507004840 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 529507004841 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 529507004842 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 529507004843 HMMPfam hit to PF00707, Translation initiation factor IF-3, C-termin, score 6.7e-55 529507004844 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 529507004845 HMMPfam hit to PF01632, Ribosomal protein L35, score 1.7e-32 529507004846 PS00936 Ribosomal protein L35 signature. 529507004847 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 529507004848 23S rRNA binding site [nucleotide binding]; other site 529507004849 L21 binding site [polypeptide binding]; other site 529507004850 L13 binding site [polypeptide binding]; other site 529507004851 HMMPfam hit to PF00453, Ribosomal protein L20, score 6.2e-67 529507004852 PS00937 Ribosomal protein L20 signature. 529507004853 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 529507004854 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 529507004855 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 529507004856 dimer interface [polypeptide binding]; other site 529507004857 motif 1; other site 529507004858 active site 529507004859 motif 2; other site 529507004860 motif 3; other site 529507004861 HMMPfam hit to PF02912, Aminoacyl tRNA synthetase class II, N, score 5.8e-36 529507004862 HMMPfam hit to PF01409, tRNA synthetases class II core domain, score 7.5e-140 529507004863 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 529507004864 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 529507004865 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 529507004866 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 529507004867 putative tRNA-binding site [nucleotide binding]; other site 529507004868 B3/4 domain; Region: B3_4; pfam03483 529507004869 tRNA synthetase B5 domain; Region: B5; smart00874 529507004870 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 529507004871 dimer interface [polypeptide binding]; other site 529507004872 motif 1; other site 529507004873 motif 3; other site 529507004874 motif 2; other site 529507004875 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 529507004876 HMMPfam hit to PF01588, tRNA binding domain, score 5.1e-43 529507004877 HMMPfam hit to PF03483, B3/4 domain, score 1.2e-104 529507004878 HMMPfam hit to PF03484, tRNA synthetase B5 domain, score 4.8e-34 529507004879 HMMPfam hit to PF03147, Ferredoxin-fold anticodon binding domain, score 3.9e-43 529507004880 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 529507004881 IHF dimer interface [polypeptide binding]; other site 529507004882 IHF - DNA interface [nucleotide binding]; other site 529507004883 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 3.3e-45 529507004884 PS00045 Bacterial histone-like DNA-binding proteins signature. 529507004885 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 529507004886 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 529507004887 ABC-ATPase subunit interface; other site 529507004888 dimer interface [polypeptide binding]; other site 529507004889 putative PBP binding regions; other site 529507004890 9 probable transmembrane helices predicted for PMI1041 by TMHMM2.0 at aa 32-54, 74-96, 100-122, 127-149, 159-181, 207-229, 249-271, 283-305 and 315-337 529507004891 HMMPfam hit to PF01032, FecCD transport family, score 3.1e-94 529507004892 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 529507004893 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 529507004894 Walker A/P-loop; other site 529507004895 ATP binding site [chemical binding]; other site 529507004896 Q-loop/lid; other site 529507004897 ABC transporter signature motif; other site 529507004898 Walker B; other site 529507004899 D-loop; other site 529507004900 H-loop/switch region; other site 529507004901 HMMPfam hit to PF00005, ABC transporter, score 7.5e-36 529507004902 PS00017 ATP/GTP-binding site motif A (P-loop). 529507004903 PS00211 ABC transporters family signature. 529507004904 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 529507004905 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 529507004906 inhibitor-cofactor binding pocket; inhibition site 529507004907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507004908 catalytic residue [active] 529507004909 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 5.9e-170 529507004910 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 529507004911 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 529507004912 Ligand binding site; other site 529507004913 Putative Catalytic site; other site 529507004914 DXD motif; other site 529507004915 HMMPfam hit to PF00535, Glycosyl transferase, score 1.6e-37 529507004916 2 probable transmembrane helices predicted for PMI1044 by TMHMM2.0 at aa 238-260 and 270-292 529507004917 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 529507004918 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 529507004919 active site 529507004920 substrate binding site [chemical binding]; other site 529507004921 cosubstrate binding site; other site 529507004922 catalytic site [active] 529507004923 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 529507004924 active site 529507004925 hexamer interface [polypeptide binding]; other site 529507004926 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 529507004927 NAD binding site [chemical binding]; other site 529507004928 substrate binding site [chemical binding]; other site 529507004929 active site 529507004930 HMMPfam hit to PF00551, Formyl transferase, score 4.7e-19 529507004931 HMMPfam hit to PF02911, Formyl transferase, C-terminal domain, score 2.8e-24 529507004932 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 529507004933 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 529507004934 putative active site [active] 529507004935 putative catalytic site [active] 529507004936 putative Zn binding site [ion binding]; other site 529507004937 HMMPfam hit to PF01522, Polysaccharide deacetylase, score 2e-05 529507004938 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 529507004939 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 529507004940 Signal peptide predicted for PMI1047 by SignalP 2.0 HMM (Signal peptide probability 0.907) with cleavage site probability 0.409 between residues 28 and 29 529507004941 HMMPfam hit to PF02366, Dolichyl-phosphate-mannose-protein mannosylt, score 1.1e-47 529507004942 10 probable transmembrane helices predicted for PMI1047 by TMHMM2.0 at aa 9-26, 84-106, 115-137, 166-188, 209-231, 261-283, 296-313, 318-337, 350-372 and 387-406 529507004943 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 529507004944 Signal peptide predicted for PMI1048 by SignalP 2.0 HMM (Signal peptide probability 0.929) with cleavage site probability 0.417 between residues 21 and 22 529507004945 4 probable transmembrane helices predicted for PMI1048 by TMHMM2.0 at aa 4-26, 38-60, 65-87 and 94-111 529507004946 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 529507004947 Signal peptide predicted for PMI1049 by SignalP 2.0 HMM (Signal peptide probability 0.805) with cleavage site probability 0.607 between residues 18 and 19 529507004948 4 probable transmembrane helices predicted for PMI1049 by TMHMM2.0 at aa 5-22, 48-70, 83-101 and 105-124 529507004949 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 529507004950 NlpC/P60 family; Region: NLPC_P60; pfam00877 529507004951 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507004952 HMMPfam hit to PF00877, NlpC/P60 family, score 9.6e-50 529507004953 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 529507004954 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 529507004955 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 529507004956 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase famil, score 4.6e-30 529507004957 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 529507004958 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 529507004959 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 4.5e-12 529507004960 PS00041 Bacterial regulatory proteins, araC family signature. 529507004961 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.4e-06 529507004962 Predicted helix-turn-helix motif with score 990.000, SD 2.56 at aa 23-44, sequence IKIDTIANKSGYSKWHLQRIFK 529507004963 hydroxyglutarate oxidase; Provisional; Region: PRK11728 529507004964 Predicted dehydrogenase [General function prediction only]; Region: COG0579 529507004965 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 4e-65 529507004966 Signal peptide predicted for PMI1053 by SignalP 2.0 HMM (Signal peptide probability 0.617) with cleavage site probability 0.405 between residues 26 and 27 529507004967 Transcriptional regulators [Transcription]; Region: FadR; COG2186 529507004968 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 529507004969 DNA-binding site [nucleotide binding]; DNA binding site 529507004970 FCD domain; Region: FCD; pfam07729 529507004971 HMMPfam hit to PF07729, FCD domain, score 1.9e-29 529507004972 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 7e-22 529507004973 PS00043 Bacterial regulatory proteins, gntR family signature. 529507004974 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 529507004975 DctM-like transporters; Region: DctM; pfam06808 529507004976 16 probable transmembrane helices predicted for PMI1055 by TMHMM2.0 at aa 26-48, 60-77, 92-114, 145-167, 187-209, 284-306, 310-332, 358-375, 380-397, 425-447, 457-476, 481-503, 507-529, 542-564, 574-596 and 608-630 529507004977 PS00017 ATP/GTP-binding site motif A (P-loop). 529507004978 HMMPfam hit to PF06808, TRAP C4-dicarboxylate transport (Dct) system, score 3.3e-32 529507004979 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 529507004980 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 529507004981 1 probable transmembrane helix predicted for PMI1056 by TMHMM2.0 at aa 12-31 529507004982 Signal peptide predicted for PMI1056 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.970 between residues 22 and 23 529507004983 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 529507004984 HMMPfam hit to PF00597, DedA family, score 6e-05 529507004985 5 probable transmembrane helices predicted for PMI1057 by TMHMM2.0 at aa 10-29, 34-56, 60-82, 113-130 and 140-162 529507004986 acetolactate synthase; Reviewed; Region: PRK08617 529507004987 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 529507004988 PYR/PP interface [polypeptide binding]; other site 529507004989 dimer interface [polypeptide binding]; other site 529507004990 TPP binding site [chemical binding]; other site 529507004991 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 529507004992 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 529507004993 TPP-binding site [chemical binding]; other site 529507004994 dimer interface [polypeptide binding]; other site 529507004995 PS00187 Thiamine pyrophosphate enzymes signature. 529507004996 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 4.3e-34 529507004997 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 1.3e-65 529507004998 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 529507004999 HMMPfam hit to PF03306, Alpha-acetolactate decarboxylase, score 1e-112 529507005000 fimbrial operon 5 529507005001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507005002 non-specific DNA binding site [nucleotide binding]; other site 529507005003 salt bridge; other site 529507005004 sequence-specific DNA binding site [nucleotide binding]; other site 529507005005 HMMPfam hit to PF01381, Helix-turn-helix, score 5.8e-14 529507005006 Predicted helix-turn-helix motif with score 2317.000, SD 7.08 at aa 36-57, sequence LTGQDLAIILNVSQQQISRYEN 529507005007 fimbrial protein PefA; Provisional; Region: PRK15214 529507005008 Signal peptide predicted for PMI1061 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 21 and 22 529507005009 HMMPfam hit to PF00419, Fimbrial protein, score 0.00095 529507005010 fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213 529507005011 PapC N-terminal domain; Region: PapC_N; pfam13954 529507005012 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 529507005013 PapC C-terminal domain; Region: PapC_C; pfam13953 529507005014 Signal peptide predicted for PMI1062 by SignalP 2.0 HMM (Signal peptide probability 0.976) with cleavage site probability 0.776 between residues 22 and 23 529507005015 HMMPfam hit to PF00577, Fimbrial Usher protein, score 2.1e-168 529507005016 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005017 fimbrial chaperone protein PefD; Provisional; Region: PRK15211 529507005018 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 529507005019 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 529507005020 Signal peptide predicted for PMI1063 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.890 between residues 22 and 23 529507005021 1 probable transmembrane helix predicted for PMI1063 by TMHMM2.0 at aa 5-27 529507005022 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 3.8e-42 529507005023 PS00635 Gram-negative pili assembly chaperone signature. 529507005024 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 5.3e-09 529507005025 Fimbrial protein; Region: Fimbrial; pfam00419 529507005026 Fimbrial protein; Region: Fimbrial; pfam00419 529507005027 Signal peptide predicted for PMI1065 by SignalP 2.0 HMM (Signal peptide probability 0.936) with cleavage site probability 0.491 between residues 24 and 25 529507005028 1 probable transmembrane helix predicted for PMI1065 by TMHMM2.0 at aa 13-35 529507005029 Signal peptide predicted for PMI1066 by SignalP 2.0 HMM (Signal peptide probability 0.985) with cleavage site probability 0.959 between residues 20 and 21 529507005030 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 529507005031 Fimbrial protein; Region: Fimbrial; pfam00419 529507005032 Signal peptide predicted for PMI1067 by SignalP 2.0 HMM (Signal peptide probability 0.827) with cleavage site probability 0.826 between residues 27 and 28 529507005033 Rhs-family protein (fragment) 529507005034 Rhs-family protein (pseudogene) 529507005035 HMMPfam hit to PF01541, GIY-YIG catalytic domain, score 0.01 529507005036 HMMPfam hit to PF05593, RHS Repeat, score 0.03 529507005037 HMMPfam hit to PF05593, RHS Repeat, score 5.3 529507005038 HMMPfam hit to PF05593, RHS Repeat, score 4.7 529507005039 HMMPfam hit to PF05593, RHS Repeat, score 0.044 529507005040 HMMPfam hit to PF05593, RHS Repeat, score 0.86 529507005041 HMMPfam hit to PF05593, RHS Repeat, score 0.00039 529507005042 HMMPfam hit to PF05593, RHS Repeat, score 0.00066 529507005043 HMMPfam hit to PF05593, RHS Repeat, score 0.0063 529507005044 HMMPfam hit to PF05593, RHS Repeat, score 0.053 529507005045 HMMPfam hit to PF05593, RHS Repeat, score 0.3 529507005046 HMMPfam hit to PF05593, RHS Repeat, score 0.0016 529507005047 HMMPfam hit to PF05488, PAAR motif, score 8e-06 529507005048 HMMPfam hit to PF05488, PAAR motif, score 0.23 529507005049 2 probable transmembrane helices predicted for PMI1078 by TMHMM2.0 at aa 35-57 and 62-84 529507005050 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507005051 HMMPfam hit to PF05488, PAAR motif, score 13 529507005052 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 529507005053 GTP-binding protein YchF; Reviewed; Region: PRK09601 529507005054 YchF GTPase; Region: YchF; cd01900 529507005055 G1 box; other site 529507005056 GTP/Mg2+ binding site [chemical binding]; other site 529507005057 Switch I region; other site 529507005058 G2 box; other site 529507005059 Switch II region; other site 529507005060 G3 box; other site 529507005061 G4 box; other site 529507005062 G5 box; other site 529507005063 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 529507005064 HMMPfam hit to PF06071, Protein of unknown function (DUF933), score 9.1e-62 529507005065 HMMPfam hit to PF01926, GTPase of unknown function, score 6.2e-32 529507005066 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005067 PS00443 Glutamine amidotransferases class-II active site. 529507005068 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 529507005069 putative active site [active] 529507005070 catalytic residue [active] 529507005071 HMMPfam hit to PF01195, Peptidyl-tRNA hydrolase, score 6.9e-98 529507005072 PS01196 Peptidyl-tRNA hydrolase signature 2. 529507005073 Signal peptide predicted for PMI1081 by SignalP 2.0 HMM (Signal peptide probability 0.735) with cleavage site probability 0.721 between residues 18 and 19 529507005074 hypothetical protein; Provisional; Region: PRK10692 529507005075 Signal peptide predicted for PMI1082 by SignalP 2.0 HMM (Signal peptide probability 0.926) with cleavage site probability 0.809 between residues 26 and 27 529507005076 2 probable transmembrane helices predicted for PMI1082 by TMHMM2.0 at aa 7-26 and 41-63 529507005077 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 529507005078 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 529507005079 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 529507005080 active site 529507005081 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 4.7e-37 529507005082 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 529507005083 PS00114 Phosphoribosyl pyrophosphate synthetase signature. 529507005084 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 529507005085 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 529507005086 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 529507005087 HMMPfam hit to PF00288, GHMP kinases ATP-binding protei, score 7.7e-31 529507005088 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 529507005089 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 529507005090 HMMPfam hit to PF03550, Outer membrane lipoprotein LolB, score 9.1e-54 529507005091 Signal peptide predicted for PMI1085 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.271 between residues 29 and 30 529507005092 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507005093 PS00589 PTS HPR component serine phosphorylation site signature. 529507005094 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 529507005095 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 529507005096 tRNA; other site 529507005097 putative tRNA binding site [nucleotide binding]; other site 529507005098 putative NADP binding site [chemical binding]; other site 529507005099 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 529507005100 HMMPfam hit to PF05201, Glutamyl-tRNAGlu reductase, N-terminal, score 1.6e-85 529507005101 PS00747 Glutamyl-tRNA reductase signature. 529507005102 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507005103 HMMPfam hit to PF05200, Glutamyl-tRNAGlu reductase, NAD(P) bin, score 3.1e-84 529507005104 HMMPfam hit to PF00745, Glutamyl-tRNAGlu reductase, dimerisati, score 1.7e-27 529507005105 peptide chain release factor 1; Validated; Region: prfA; PRK00591 529507005106 This domain is found in peptide chain release factors; Region: PCRF; smart00937 529507005107 RF-1 domain; Region: RF-1; pfam00472 529507005108 HMMPfam hit to PF03462, PCRF domain, score 8.7e-70 529507005109 HMMPfam hit to PF00472, Peptidyl-tRNA hydrolase domain, score 2.1e-74 529507005110 PS00745 Prokaryotic-type class I peptide chain release factors signature. 529507005111 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 529507005112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507005113 PS00092 N-6 Adenine-specific DNA methylases signature. 529507005114 hypothetical protein; Provisional; Region: PRK10941 529507005115 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 529507005116 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 529507005117 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 529507005118 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 529507005119 HMMPfam hit to PF00793, DAHP synthetase I family, score 2.3e-116 529507005120 radical SAM protein, TIGR01212 family; Region: TIGR01212 529507005121 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 529507005122 FeS/SAM binding site; other site 529507005123 HMMPfam hit to PF04055, Radical SAM superfamily, score 1.6e-12 529507005124 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 529507005125 putative transporter; Provisional; Region: PRK11660 529507005126 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 529507005127 Sulfate transporter family; Region: Sulfate_transp; pfam00916 529507005128 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 529507005129 HMMPfam hit to PF01740, STAS domain, score 1.2e-12 529507005130 HMMPfam hit to PF00916, Sulfate transporter family, score 2.9e-92 529507005131 10 probable transmembrane helices predicted for PMI1093 by TMHMM2.0 at aa 33-55, 60-82, 102-124, 128-150, 171-193, 208-227, 279-301, 316-338, 359-390 and 410-441 529507005132 PS01130 Sulfate transporters signature. 529507005133 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 529507005134 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 529507005135 putative ligand binding site [chemical binding]; other site 529507005136 NAD binding site [chemical binding]; other site 529507005137 dimerization interface [polypeptide binding]; other site 529507005138 catalytic site [active] 529507005139 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 8.3e-14 529507005140 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 529507005141 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 529507005142 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 529507005143 PS00338 Somatotropin, prolactin and related hormones signature 2. 529507005144 HMMPfam hit to PF03171, 2OG-Fe(II) oxygenase superfamily, score 5.7e-10 529507005145 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 529507005146 HMMPfam hit to PF06192, Cytoplasmic chaperone TorD, score 4.4e-17 529507005147 lipoprotein; Provisional; Region: PRK10598 529507005148 HMMPfam hit to PF07273, Protein of unknown function (DUF1439), score 4.2e-60 529507005149 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507005150 Signal peptide predicted for PMI1098 by SignalP 2.0 HMM (Signal peptide probability 0.966) with cleavage site probability 0.963 between residues 18 and 19 529507005151 multidrug resistance protein MdtH; Provisional; Region: PRK11646 529507005152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507005153 putative substrate translocation pore; other site 529507005154 10 probable transmembrane helices predicted for PMI1099 by TMHMM2.0 at aa 13-35, 99-116, 136-158, 163-185, 213-235, 245-264, 276-293, 297-314, 335-357 and 367-384 529507005155 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.1e-47 529507005156 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 529507005157 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 529507005158 PS00050 Ribosomal protein L23 signature. 529507005159 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 2.8e-12 529507005160 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 529507005161 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 529507005162 Signal peptide predicted for PMI1101 by SignalP 2.0 HMM (Signal peptide probability 0.810) with cleavage site probability 0.445 between residues 21 and 22 529507005163 13 probable transmembrane helices predicted for PMI1101 by TMHMM2.0 at aa 26-45, 91-113, 133-152, 159-181, 186-203, 237-259, 274-296, 316-338, 353-375, 382-404, 408-430, 443-465 and 478-500 529507005164 HMMPfam hit to PF03023, MviN-like protein, score 1.5e-195 529507005165 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 529507005166 Signal peptide predicted for PMI1102 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.805 between residues 21 and 22 529507005167 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507005168 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 529507005169 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 529507005170 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 529507005171 active site 529507005172 HIGH motif; other site 529507005173 KMSK motif region; other site 529507005174 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 529507005175 tRNA binding surface [nucleotide binding]; other site 529507005176 anticodon binding site; other site 529507005177 HMMPfam hit to PF05746, DALR anticodon binding domain, score 3.8e-52 529507005178 HMMPfam hit to PF00750, tRNA synthetases class I (R), score 2.5e-193 529507005179 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 529507005180 HMMPfam hit to PF03485, Arginyl tRNA synthetase N terminal do, score 2.8e-29 529507005181 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 529507005182 putative metal binding site [ion binding]; other site 529507005183 HMMPfam hit to PF06185, Protein of unknown function (DUF991), score 7e-79 529507005184 copper homeostasis protein CutC; Provisional; Region: PRK11572 529507005185 HMMPfam hit to PF03932, CutC family, score 4.9e-94 529507005186 Signal peptide predicted for PMI1106 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.989 between residues 20 and 21 529507005187 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 529507005188 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 529507005189 ABC transporter; Region: ABC_tran_2; pfam12848 529507005190 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 529507005191 HMMPfam hit to PF00005, ABC transporter, score 7.7e-24 529507005192 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005193 HMMPfam hit to PF00005, ABC transporter, score 6.5e-23 529507005194 PS00211 ABC transporters family signature. 529507005195 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005196 Methyltransferase domain; Region: Methyltransf_23; pfam13489 529507005197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507005198 S-adenosylmethionine binding site [chemical binding]; other site 529507005199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507005200 S-adenosylmethionine binding site [chemical binding]; other site 529507005201 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 529507005202 4 probable transmembrane helices predicted for PMI1110 by TMHMM2.0 at aa 5-22, 43-65, 70-92 and 105-127 529507005203 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 529507005204 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 529507005205 dimer interface [polypeptide binding]; other site 529507005206 anticodon binding site; other site 529507005207 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 529507005208 homodimer interface [polypeptide binding]; other site 529507005209 motif 1; other site 529507005210 active site 529507005211 motif 2; other site 529507005212 GAD domain; Region: GAD; pfam02938 529507005213 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 529507005214 active site 529507005215 motif 3; other site 529507005216 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 5.8e-29 529507005217 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 1.4e-14 529507005218 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 529507005219 HMMPfam hit to PF02938, GAD domain, score 1.9e-40 529507005220 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 529507005221 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 529507005222 nudix motif; other site 529507005223 HMMPfam hit to PF00293, NUDIX domain, score 7.5e-22 529507005224 PS00893 mutT domain signature. 529507005225 hypothetical protein; Validated; Region: PRK00110 529507005226 HMMPfam hit to PF01709, Domain of unknown function DUF28, score 2e-153 529507005227 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 529507005228 active site 529507005229 putative DNA-binding cleft [nucleotide binding]; other site 529507005230 dimer interface [polypeptide binding]; other site 529507005231 HMMPfam hit to PF02075, Crossover junction endodeoxyribonuclease Ruv, score 1.8e-92 529507005232 PS01321 Crossover junction endodeoxyribonuclease ruvC signature. 529507005233 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 529507005234 RuvA N terminal domain; Region: RuvA_N; pfam01330 529507005235 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 529507005236 HMMPfam hit to PF01330, RuvA N terminal domain, score 1.1e-27 529507005237 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 0.053 529507005238 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 0.013 529507005239 HMMPfam hit to PF07499, RuvA, C-terminal domain, score 1.2e-15 529507005240 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 529507005241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 529507005242 Walker A motif; other site 529507005243 ATP binding site [chemical binding]; other site 529507005244 Walker B motif; other site 529507005245 arginine finger; other site 529507005246 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 529507005247 HMMPfam hit to PF05496, Holliday junction DNA helicase ruvB N-termin, score 1.4e-26 529507005248 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 2e-32 529507005249 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005250 HMMPfam hit to PF05491, Holliday junction DNA helicase ruvB C-termin, score 4.6e-54 529507005251 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 529507005252 HMMPfam hit to PF05638, Protein of unknown function (DUF796), score 1.2e-87 529507005253 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 529507005254 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 529507005255 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 529507005256 HMMPfam hit to PF04524, Protein of unknown function, DUF586, score 1.8e-39 529507005257 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 529507005258 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 529507005259 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 529507005260 RHS Repeat; Region: RHS_repeat; pfam05593 529507005261 RHS Repeat; Region: RHS_repeat; pfam05593 529507005262 RHS Repeat; Region: RHS_repeat; cl11982 529507005263 RHS Repeat; Region: RHS_repeat; pfam05593 529507005264 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 529507005265 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 529507005266 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005267 HMMPfam hit to PF05593, RHS Repeat, score 1.4 529507005268 HMMPfam hit to PF05593, RHS Repeat, score 9.2 529507005269 HMMPfam hit to PF05593, RHS Repeat, score 3 529507005270 HMMPfam hit to PF05593, RHS Repeat, score 0.00012 529507005271 HMMPfam hit to PF05593, RHS Repeat, score 0.011 529507005272 HMMPfam hit to PF05593, RHS Repeat, score 0.0088 529507005273 HMMPfam hit to PF05593, RHS Repeat, score 0.0083 529507005274 HMMPfam hit to PF05593, RHS Repeat, score 0.8 529507005275 HMMPfam hit to PF05593, RHS Repeat, score 0.17 529507005276 HMMPfam hit to PF05593, RHS Repeat, score 2.7 529507005277 HMMPfam hit to PF05593, RHS Repeat, score 6.3 529507005278 HMMPfam hit to PF05593, RHS Repeat, score 0.011 529507005279 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 529507005280 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 529507005281 HMMPfam hit to PF05593, RHS Repeat, score 6.7 529507005282 HMMPfam hit to PF05593, RHS Repeat, score 0.011 529507005283 transposase (pseudogene) 529507005284 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 529507005285 Also similar to parts of PMI1120, PMI1125, PMI1128, PMI1131, PMI1138, PMI1140, PMI1142, PMI1069, PMI1073 and PMI1077; Rhs-family protein (fragment) 529507005286 Also similar to parts of PMI1120, PMI1125, PMI1128, PMI1131, PMI1138, PMI1137, PMI1142, PMI1069, PMI1073 and PMI1077; Rhs-family protein (fragment) 529507005287 Also similar to parts of PMI1120, PMI1125, PMI1131, PMI1137, PMI1138, PMI1140, PMI1128, PMI1073 and PMI1077; Rhs-family protein (fragment) 529507005288 HMMPfam hit to PF05593, RHS Repeat, score 6.7 529507005289 HMMPfam hit to PF05593, RHS Repeat, score 0.011 529507005290 ribonuclease (fragment) 529507005291 Barstar (barnase inhibitor); Region: Barstar; pfam01337 529507005292 RNAase interaction site [polypeptide binding]; other site 529507005293 integrase (fragment) 529507005294 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 529507005295 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 529507005296 ABC-ATPase subunit interface; other site 529507005297 dimer interface [polypeptide binding]; other site 529507005298 putative PBP binding regions; other site 529507005299 HMMPfam hit to PF00950, ABC 3 transport family, score 7.1e-112 529507005300 7 probable transmembrane helices predicted for PMI1150 by TMHMM2.0 at aa 5-27, 48-70, 85-107, 120-142, 178-200, 213-235 and 239-258 529507005301 Signal peptide predicted for PMI1150 by SignalP 2.0 HMM (Signal peptide probability 0.981) with cleavage site probability 0.960 between residues 18 and 19 529507005302 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 529507005303 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 529507005304 HMMPfam hit to PF00005, ABC transporter, score 8.4e-47 529507005305 PS00211 ABC transporters family signature. 529507005306 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005307 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 529507005308 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 529507005309 metal binding site [ion binding]; metal-binding site 529507005310 Signal peptide predicted for PMI1152 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 32 and 33 529507005311 HMMPfam hit to PF01297, Periplasmic solute binding protein family, score 1.9e-37 529507005312 putative peptidase; Provisional; Region: PRK11649 529507005313 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 529507005314 Peptidase family M23; Region: Peptidase_M23; pfam01551 529507005315 HMMPfam hit to PF01476, LysM domain, score 1.1e-05 529507005316 HMMPfam hit to PF01551, Peptidase family M23, score 1.9e-52 529507005317 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 529507005318 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 529507005319 putative acyl-acceptor binding pocket; other site 529507005320 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltr, score 7.3e-117 529507005321 1 probable transmembrane helix predicted for PMI1154 by TMHMM2.0 at aa 27-44 529507005322 pyruvate kinase; Provisional; Region: PRK05826 529507005323 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 529507005324 domain interfaces; other site 529507005325 active site 529507005326 HMMPfam hit to PF02887, Pyruvate kinase, alpha/beta domain, score 5.9e-55 529507005327 HMMPfam hit to PF00224, Pyruvate kinase, barrel domain, score 2.2e-215 529507005328 PS00110 Pyruvate kinase active site signature. 529507005329 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 529507005330 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 529507005331 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 529507005332 putative active site [active] 529507005333 HMMPfam hit to PF01380, SIS domain, score 6.1e-27 529507005334 HMMPfam hit to PF01418, Helix-turn-helix domain, rpiR family, score 2.6e-42 529507005335 Predicted helix-turn-helix motif with score 1099.000, SD 2.93 at aa 35-56, sequence SSIALMAKTADVSEPTVNRFCR 529507005336 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 529507005337 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 529507005338 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 529507005339 HMMPfam hit to PF00479, Glucose-6-phosphate dehydrogenase, NAD bindi, score 1.1e-82 529507005340 PS00069 Glucose-6-phosphate dehydrogenase active site. 529507005341 HMMPfam hit to PF02781, Glucose-6-phosphate dehydrogenase, C-termina, score 1.3e-192 529507005342 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 529507005343 4 probable transmembrane helices predicted for PMI1158 by TMHMM2.0 at aa 2-19, 29-51, 56-78 and 88-105 529507005344 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 1e-26 529507005345 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 529507005346 4 probable transmembrane helices predicted for PMI1159 by TMHMM2.0 at aa 11-33, 38-60, 70-92 and 99-113 529507005347 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 2e-29 529507005348 1 probable transmembrane helix predicted for PMI1160 by TMHMM2.0 at aa 15-37 529507005349 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 529507005350 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 529507005351 NAD(P) binding site [chemical binding]; other site 529507005352 putative active site [active] 529507005353 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 529507005354 homotrimer interaction site [polypeptide binding]; other site 529507005355 putative active site [active] 529507005356 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 6.5e-29 529507005357 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 529507005358 DEAD/DEAH box helicase; Region: DEAD; pfam00270 529507005359 Alpha-helical domain of GINS complex proteins; Sld5, Psf1, Psf2 and Psf3; Region: GINS_A; cl17012 529507005360 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 529507005361 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005362 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 529507005363 Glycoprotease family; Region: Peptidase_M22; pfam00814 529507005364 HMMPfam hit to PF00814, Glycoprotease family, score 2e-23 529507005365 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 529507005366 Signal peptide predicted for PMI1165 by SignalP 2.0 HMM (Signal peptide probability 0.904) with cleavage site probability 0.373 between residues 27 and 28 529507005367 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507005368 HMMPfam hit to PF03843, Outer membrane lipoprotein Slp family, score 9.4e-50 529507005369 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 529507005370 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 529507005371 acyl-activating enzyme (AAE) consensus motif; other site 529507005372 putative AMP binding site [chemical binding]; other site 529507005373 putative active site [active] 529507005374 putative CoA binding site [chemical binding]; other site 529507005375 HMMPfam hit to PF00501, AMP-binding enzyme, score 2.9e-129 529507005376 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 529507005377 PS00455 AMP-binding domain signature. 529507005378 ribonuclease D; Provisional; Region: PRK10829 529507005379 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 529507005380 catalytic site [active] 529507005381 putative active site [active] 529507005382 putative substrate binding site [chemical binding]; other site 529507005383 HRDC domain; Region: HRDC; pfam00570 529507005384 HMMPfam hit to PF01612, 3'-5' exonuclease, score 9.1e-48 529507005385 HMMPfam hit to PF00570, HRDC domain, score 2.8e-20 529507005386 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 529507005387 HMMPfam hit to PF03776, Septum formation topological specificity fac, score 1.8e-46 529507005388 cell division inhibitor MinD; Provisional; Region: PRK10818 529507005389 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 529507005390 Switch I; other site 529507005391 Switch II; other site 529507005392 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 1.3e-26 529507005393 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005394 septum formation inhibitor; Reviewed; Region: minC; PRK03511 529507005395 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 529507005396 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 529507005397 HMMPfam hit to PF03775, Septum formation inhibitor MinC, C-terminal, score 1.9e-61 529507005398 HMMPfam hit to PF05209, Septum formation inhibitor MinC, N-terminal, score 7.2e-36 529507005399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 529507005400 HMMPfam hit to PF05166, Family of unknown function (DUF709), score 7e-49 529507005401 Transglycosylase SLT domain; Region: SLT_2; pfam13406 529507005402 Uncharacterized conserved protein (DUF2042); Region: DUF2042; cl10727 529507005403 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 529507005404 N-acetyl-D-glucosamine binding site [chemical binding]; other site 529507005405 catalytic residue [active] 529507005406 Signal peptide predicted for PMI1172 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.334 between residues 27 and 28 529507005407 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507005408 hypothetical protein; Provisional; Region: PRK10691 529507005409 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 529507005410 HMMPfam hit to PF01557, Fumarylacetoacetate (FAA) hydrolase fam, score 4.6e-69 529507005411 hypothetical protein; Provisional; Region: PRK05170 529507005412 HMMPfam hit to PF05779, Bacterial protein of unknown function (DUF83, score 1.1e-96 529507005413 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 529507005414 HMMPfam hit to PF03649, Uncharacterised protein family (UPF0014), score 1.9e-125 529507005415 7 probable transmembrane helices predicted for PMI1175 by TMHMM2.0 at aa 5-24, 36-58, 62-79, 91-113, 123-145, 192-209 and 219-241 529507005416 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 529507005417 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507005418 Walker A/P-loop; other site 529507005419 ATP binding site [chemical binding]; other site 529507005420 Q-loop/lid; other site 529507005421 ABC transporter signature motif; other site 529507005422 Walker B; other site 529507005423 D-loop; other site 529507005424 H-loop/switch region; other site 529507005425 HMMPfam hit to PF00005, ABC transporter, score 1.9e-44 529507005426 PS00211 ABC transporters family signature. 529507005427 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005428 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 529507005429 Signal peptide predicted for PMI1177 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 22 and 23 529507005430 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 529507005431 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 529507005432 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 529507005433 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 9.2e-13 529507005434 PS00041 Bacterial regulatory proteins, araC family signature. 529507005435 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 2.4e-08 529507005436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 529507005437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 529507005438 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 1.9e-11 529507005439 Predicted helix-turn-helix motif with score 1026.000, SD 2.68 at aa 41-62, sequence VSIDEISRYARVTKGAFYHHFS 529507005440 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 529507005441 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 529507005442 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 529507005443 dimer interface [polypeptide binding]; other site 529507005444 putative CheW interface [polypeptide binding]; other site 529507005445 Signal peptide predicted for PMI1180 by SignalP 2.0 HMM (Signal peptide probability 0.874) with cleavage site probability 0.616 between residues 29 and 30 529507005446 2 probable transmembrane helices predicted for PMI1180 by TMHMM2.0 at aa 13-30 and 183-205 529507005447 HMMPfam hit to PF00672, HAMP domain, score 1.1e-08 529507005448 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 6.3e-90 529507005449 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 529507005450 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 529507005451 putative ligand binding site [chemical binding]; other site 529507005452 putative NAD binding site [chemical binding]; other site 529507005453 catalytic site [active] 529507005454 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 1.8e-93 529507005455 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 529507005456 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 529507005457 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 529507005458 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrog, score 3.4e-19 529507005459 hypothetical protein; Provisional; Region: PRK10695 529507005460 Signal peptide predicted for PMI1182 by SignalP 2.0 HMM (Signal peptide probability 0.946) with cleavage site probability 0.547 between residues 36 and 37 529507005461 Signal peptide predicted for PMI1183 by SignalP 2.0 HMM (Signal peptide probability 0.708) with cleavage site probability 0.285 between residues 31 and 32 529507005462 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 529507005463 1 probable transmembrane helix predicted for PMI1183 by TMHMM2.0 at aa 9-31 529507005464 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507005465 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 529507005466 Signal peptide predicted for PMI1184 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 23 and 24 529507005467 HMMPfam hit to PF07027, Protein of unknown function (DUF1318), score 7.4e-46 529507005468 Fimbrial protein; Region: Fimbrial; pfam00419 529507005469 fimbrial operon 6 529507005470 HMMPfam hit to PF00419, Fimbrial protein, score 0.017 529507005471 Signal peptide predicted for PMI1185 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.945 between residues 23 and 24 529507005472 1 probable transmembrane helix predicted for PMI1185 by TMHMM2.0 at aa 5-22 529507005473 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 529507005474 PapC N-terminal domain; Region: PapC_N; pfam13954 529507005475 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 529507005476 PapC C-terminal domain; Region: PapC_C; pfam13953 529507005477 HMMPfam hit to PF00577, Fimbrial Usher protein, score 1e-99 529507005478 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 529507005479 Signal peptide predicted for PMI1186 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.977 between residues 25 and 26 529507005480 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 529507005481 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 529507005482 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 529507005483 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 4.2e-11 529507005484 1 probable transmembrane helix predicted for PMI1187 by TMHMM2.0 at aa 5-24 529507005485 Signal peptide predicted for PMI1187 by SignalP 2.0 HMM (Signal peptide probability 0.970) with cleavage site probability 0.969 between residues 20 and 21 529507005486 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507005487 Fimbrial protein; Region: Fimbrial; cl01416 529507005488 HMMPfam hit to PF00419, Fimbrial protein, score 0.015 529507005489 Signal peptide predicted for PMI1188 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.903 between residues 26 and 27 529507005490 Truncated at C-terminus relative to database matches. Highly similar (75.5 38d) to the nearby CDS PMI1191; acyl carrier protein phosphodiesterase (fragment) 529507005491 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507005492 HMMPfam hit to PF00419, Fimbrial protein, score 0.0078 529507005493 Signal peptide predicted for PMI1190 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.964 between residues 26 and 27 529507005494 azoreductase; Reviewed; Region: PRK00170 529507005495 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 529507005496 HMMPfam hit to PF02525, Flavodoxin-like fold, score 2e-36 529507005497 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 529507005498 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 529507005499 ATP binding site [chemical binding]; other site 529507005500 putative Mg++ binding site [ion binding]; other site 529507005501 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 529507005502 nucleotide binding region [chemical binding]; other site 529507005503 ATP-binding site [chemical binding]; other site 529507005504 Helicase associated domain (HA2); Region: HA2; pfam04408 529507005505 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 529507005506 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 529507005507 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 3.4e-08 529507005508 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005509 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 3.2e-12 529507005510 HMMPfam hit to PF04408, Helicase associated domain (HA2), score 1.5e-25 529507005511 HMMPfam hit to PF07717, Domain of unknown function (DUF1605), score 1e-19 529507005512 fimbrial operon 7 529507005513 Signal peptide predicted for PMI1193 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.877 between residues 22 and 23 529507005514 Fimbrial protein; Region: Fimbrial; cl01416 529507005515 HMMPfam hit to PF00419, Fimbrial protein, score 0.0079 529507005516 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 529507005517 PapC N-terminal domain; Region: PapC_N; pfam13954 529507005518 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 529507005519 PapC C-terminal domain; Region: PapC_C; pfam13953 529507005520 HMMPfam hit to PF00577, Fimbrial Usher protein, score 2.9e-88 529507005521 PS00284 Serpins signature. 529507005522 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 529507005523 Signal peptide predicted for PMI1195 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.988 between residues 19 and 20 529507005524 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 529507005525 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 529507005526 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 529507005527 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 2.8e-10 529507005528 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 1.7e-33 529507005529 1 probable transmembrane helix predicted for PMI1196 by TMHMM2.0 at aa 5-24 529507005530 Signal peptide predicted for PMI1196 by SignalP 2.0 HMM (Signal peptide probability 0.984) with cleavage site probability 0.916 between residues 21 and 22 529507005531 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507005532 HMMPfam hit to PF00419, Fimbrial protein, score 4.2e-07 529507005533 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507005534 Signal peptide predicted for PMI1197 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 24 and 25 529507005535 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 529507005536 13 probable transmembrane helices predicted for PMI1198 by TMHMM2.0 at aa 5-27, 37-59, 90-112, 127-149, 161-183, 203-222, 235-257, 272-294, 331-350, 360-382, 389-406, 410-429 and 441-463 529507005537 HMMPfam hit to PF00324, Amino acid permease, score 2.5e-05 529507005538 Signal peptide predicted for PMI1198 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.687 between residues 21 and 22 529507005539 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 529507005540 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 529507005541 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 529507005542 PS01067 Protein secE/sec61-gamma signature. 529507005543 HMMPfam hit to PF07338, Protein of unknown function (DUF1471), score 2.3e-08 529507005544 Signal peptide predicted for PMI1199 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.961 between residues 23 and 24 529507005545 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 529507005546 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 529507005547 ligand binding site [chemical binding]; other site 529507005548 homodimer interface [polypeptide binding]; other site 529507005549 NAD(P) binding site [chemical binding]; other site 529507005550 trimer interface B [polypeptide binding]; other site 529507005551 trimer interface A [polypeptide binding]; other site 529507005552 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 529507005553 HMMPfam hit to PF05222, Alanine dehydrogenase/PNT, N-terminal dom, score 8e-72 529507005554 PS00836 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1. 529507005555 HMMPfam hit to PF01262, Alanine dehydrogenase/PNT, C-terminal dom, score 9.8e-113 529507005556 5 probable transmembrane helices predicted for PMI1200 by TMHMM2.0 at aa 169-191, 402-419, 423-445, 452-471 and 476-498 529507005557 PS00837 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2. 529507005558 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507005559 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 529507005560 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 529507005561 Signal peptide predicted for PMI1201 by SignalP 2.0 HMM (Signal peptide probability 0.637) with cleavage site probability 0.372 between residues 22 and 23 529507005562 HMMPfam hit to PF02233, NAD(P) transhydrogenase beta subunit, score 0 529507005563 9 probable transmembrane helices predicted for PMI1201 by TMHMM2.0 at aa 5-24, 36-53, 57-74, 86-105, 120-142, 163-180, 185-207, 214-236 and 240-259 529507005564 universal stress protein UspE; Provisional; Region: PRK11175 529507005565 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 529507005566 Ligand Binding Site [chemical binding]; other site 529507005567 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 529507005568 Ligand Binding Site [chemical binding]; other site 529507005569 HMMPfam hit to PF00582, Universal stress protein family, score 5.6e-07 529507005570 HMMPfam hit to PF00582, Universal stress protein family, score 7.6e-15 529507005571 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 529507005572 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 529507005573 ligand binding site [chemical binding]; other site 529507005574 flexible hinge region; other site 529507005575 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 529507005576 putative switch regulator; other site 529507005577 non-specific DNA interactions [nucleotide binding]; other site 529507005578 DNA binding site [nucleotide binding] 529507005579 sequence specific DNA binding site [nucleotide binding]; other site 529507005580 putative cAMP binding site [chemical binding]; other site 529507005581 HMMPfam hit to PF00325, Bacterial regulatory proteins, crp famil, score 3.3e-15 529507005582 PS00042 Bacterial regulatory proteins, crp family signature. 529507005583 Predicted helix-turn-helix motif with score 1841.000, SD 5.46 at aa 199-220, sequence MTRGDIGNYLGLTVETISRLLG 529507005584 HMMPfam hit to PF00027, Cyclic nucleotide-binding domain, score 6.4e-21 529507005585 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 529507005586 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 529507005587 putative [Fe4-S4] binding site [ion binding]; other site 529507005588 putative molybdopterin cofactor binding site [chemical binding]; other site 529507005589 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 529507005590 putative molybdopterin cofactor binding site; other site 529507005591 Signal peptide predicted for PMI1204 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.623 between residues 42 and 43 529507005592 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 do, score 3.2e-05 529507005593 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 4e-79 529507005594 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 529507005595 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 1.3e-32 529507005596 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 529507005597 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 529507005598 4Fe-4S binding domain; Region: Fer4; pfam00037 529507005599 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.014 529507005600 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507005601 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 4.6e-08 529507005602 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507005603 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 529507005604 8 probable transmembrane helices predicted for PMI1206 by TMHMM2.0 at aa 10-30, 43-65, 87-106, 113-135, 148-170, 182-199, 232-254 and 259-281 529507005605 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507005606 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 529507005607 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 529507005608 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 529507005609 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.0013 529507005610 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 9.6e-07 529507005611 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507005612 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 4.6e-06 529507005613 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.00014 529507005614 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 529507005615 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 529507005616 NAD(P) binding site [chemical binding]; other site 529507005617 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 3.3e-84 529507005618 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 529507005619 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 529507005620 PS00190 Cytochrome c family heme-binding site signature. 529507005621 Predicted transcriptional regulators [Transcription]; Region: COG1695 529507005622 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 529507005623 HMMPfam hit to PF03551, Transcriptional regulator PadR-like family, score 5e-23 529507005624 Signal peptide predicted for PMI1212 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.996 between residues 56 and 57 529507005625 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 529507005626 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 529507005627 dimer interface [polypeptide binding]; other site 529507005628 decamer (pentamer of dimers) interface [polypeptide binding]; other site 529507005629 catalytic triad [active] 529507005630 peroxidatic and resolving cysteines [active] 529507005631 HMMPfam hit to PF00578, AhpC/TSA family, score 1.7e-63 529507005632 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 529507005633 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 529507005634 catalytic residue [active] 529507005635 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 529507005636 catalytic residues [active] 529507005637 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 529507005638 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreducta, score 1.7e-64 529507005639 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 529507005640 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 529507005641 Signal peptide predicted for PMI1215 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.979 between residues 29 and 30 529507005642 PS00120 Lipases, serine active site. 529507005643 4 probable transmembrane helices predicted for PMI1216 by TMHMM2.0 at aa 21-43, 63-85, 92-114 and 124-146 529507005644 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 529507005645 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 529507005646 Predicted permeases [General function prediction only]; Region: COG0679 529507005647 Signal peptide predicted for PMI1218 by SignalP 2.0 HMM (Signal peptide probability 0.859) with cleavage site probability 0.840 between residues 18 and 19 529507005648 HMMPfam hit to PF03547, Auxin Efflux Carrier, score 1.2e-05 529507005649 9 probable transmembrane helices predicted for PMI1218 by TMHMM2.0 at aa 4-21, 30-49, 64-83, 104-126, 130-152, 159-181, 191-213, 234-256 and 279-301 529507005650 AMP nucleosidase; Provisional; Region: PRK08292 529507005651 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 529507005652 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 529507005653 HMMPfam hit to PF01048, Phosphorylase family, score 4.7e-79 529507005654 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 529507005655 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 529507005656 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 529507005657 active site 529507005658 DNA binding site [nucleotide binding] 529507005659 Int/Topo IB signature motif; other site 529507005660 HMMPfam hit to PF00589, Phage integrase family, score 3.4e-22 529507005661 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 0.0037 529507005662 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 529507005663 catalytic nucleophile [active] 529507005664 HMMPfam hit to PF01112, Asparaginase, score 4.3e-111 529507005665 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005666 Signal peptide predicted for PMI1222 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 23 and 24 529507005667 HlyD family secretion protein; Region: HlyD; pfam00529 529507005668 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 529507005669 HlyD family secretion protein; Region: HlyD_3; pfam13437 529507005670 1 probable transmembrane helix predicted for PMI1223 by TMHMM2.0 at aa 9-27 529507005671 HMMPfam hit to PF00529, HlyD family secretion protein, score 8.8e-20 529507005672 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 529507005673 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 529507005674 Walker A/P-loop; other site 529507005675 ATP binding site [chemical binding]; other site 529507005676 Q-loop/lid; other site 529507005677 ABC transporter signature motif; other site 529507005678 Walker B; other site 529507005679 D-loop; other site 529507005680 H-loop/switch region; other site 529507005681 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 529507005682 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 529507005683 Walker A/P-loop; other site 529507005684 ATP binding site [chemical binding]; other site 529507005685 Q-loop/lid; other site 529507005686 ABC transporter signature motif; other site 529507005687 Walker B; other site 529507005688 D-loop; other site 529507005689 H-loop/switch region; other site 529507005690 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 529507005691 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 529507005692 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 529507005693 HMMPfam hit to PF00005, ABC transporter, score 3.7e-65 529507005694 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005695 PS00211 ABC transporters family signature. 529507005696 HMMPfam hit to PF00005, ABC transporter, score 2.4e-51 529507005697 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005698 5 probable transmembrane helices predicted for PMI1224 by TMHMM2.0 at aa 569-591, 725-747, 780-802, 809-831 and 895-917 529507005699 HMMPfam hit to PF01061, ABC-2 type transporter, score 1.9e-05 529507005700 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 529507005701 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 529507005702 Signal peptide predicted for PMI1225 by SignalP 2.0 HMM (Signal peptide probability 0.964) with cleavage site probability 0.717 between residues 41 and 42 529507005703 6 probable transmembrane helices predicted for PMI1225 by TMHMM2.0 at aa 26-48, 178-200, 231-253, 257-279, 286-308 and 344-366 529507005704 HMMPfam hit to PF01061, ABC-2 type transporter, score 3.9e-25 529507005705 PS00890 ABC-2 type transport system integral membrane proteins signature. 529507005706 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 529507005707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507005708 active site 529507005709 phosphorylation site [posttranslational modification] 529507005710 intermolecular recognition site; other site 529507005711 dimerization interface [polypeptide binding]; other site 529507005712 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 529507005713 DNA binding site [nucleotide binding] 529507005714 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 1.6e-17 529507005715 HMMPfam hit to PF00072, Response regulator receiver domain, score 5.7e-37 529507005716 sensor protein KdpD; Provisional; Region: PRK10490 529507005717 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 529507005718 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 529507005719 Ligand Binding Site [chemical binding]; other site 529507005720 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 529507005721 GAF domain; Region: GAF_3; pfam13492 529507005722 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 529507005723 dimer interface [polypeptide binding]; other site 529507005724 phosphorylation site [posttranslational modification] 529507005725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 529507005726 ATP binding site [chemical binding]; other site 529507005727 Mg2+ binding site [ion binding]; other site 529507005728 G-X-G motif; other site 529507005729 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 8.1e-35 529507005730 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 3.7e-16 529507005731 4 probable transmembrane helices predicted for PMI1227 by TMHMM2.0 at aa 407-426, 433-450, 454-476 and 483-505 529507005732 HMMPfam hit to PF00582, Universal stress protein family, score 0.00012 529507005733 HMMPfam hit to PF02702, Osmosensitive K+ channel His kinase sensor, score 1.6e-144 529507005734 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005735 exported protein (fragment);This CDS is truncated at N-terminus. 529507005736 HMMPfam hit to PF03401, Bordetella uptake gene (bug) product, score 0.0012 529507005737 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 529507005738 Signal peptide predicted for PMI1229 by SignalP 2.0 HMM (Signal peptide probability 0.965) with cleavage site probability 0.770 between residues 29 and 30 529507005739 4 probable transmembrane helices predicted for PMI1229 by TMHMM2.0 at aa 7-29, 34-53, 74-103 and 118-140 529507005740 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 529507005741 12 probable transmembrane helices predicted for PMI1230 by TMHMM2.0 at aa 7-29, 39-61, 106-128, 143-160, 165-184, 194-216, 261-283, 318-340, 360-382, 397-419, 432-449 and 464-486 529507005742 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507005743 HMMPfam hit to PF01970, Integral membrane protein DUF112, score 2.4e-118 529507005744 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 529507005745 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 529507005746 HMMPfam hit to PF02733, Dak1 domain, score 7.6e-100 529507005747 DAK2 domain; Region: Dak2; pfam02734 529507005748 HMMPfam hit to PF02734, DAK2 domain, score 4.8e-06 529507005749 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 529507005750 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 529507005751 inhibitor site; inhibition site 529507005752 active site 529507005753 dimer interface [polypeptide binding]; other site 529507005754 catalytic residue [active] 529507005755 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase family, score 2.3e-55 529507005756 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 529507005757 tetramer interface [polypeptide binding]; other site 529507005758 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 529507005759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507005760 catalytic residue [active] 529507005761 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 1.8e-83 529507005762 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 529507005763 homotrimer interaction site [polypeptide binding]; other site 529507005764 putative active site [active] 529507005765 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 1.8e-24 529507005766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 529507005767 Coenzyme A binding pocket [chemical binding]; other site 529507005768 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 7.7e-13 529507005769 leucine export protein LeuE; Provisional; Region: PRK10958 529507005770 6 probable transmembrane helices predicted for PMI1237 by TMHMM2.0 at aa 10-32, 45-67, 77-99, 120-142, 157-179 and 192-214 529507005771 HMMPfam hit to PF01810, LysE type translocator, score 9.1e-53 529507005772 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 529507005773 HMMPfam hit to PF01243, Pyridoxamine 5'-phosphate oxidase, score 3.4e-19 529507005774 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 529507005775 endonuclease III; Region: ENDO3c; smart00478 529507005776 minor groove reading motif; other site 529507005777 helix-hairpin-helix signature motif; other site 529507005778 substrate binding pocket [chemical binding]; other site 529507005779 active site 529507005780 HMMPfam hit to PF00730, HhH-GPD superfamily base excision DNA repair, score 1.6e-10 529507005781 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 529507005782 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 529507005783 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 529507005784 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 529507005785 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 529507005786 DNA binding site [nucleotide binding] 529507005787 active site 529507005788 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix, score 4.7e-13 529507005789 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix, score 0.22 529507005790 HMMPfam hit to PF02870, 6-O-methylguanine DNA methyltransfera, score 4.8e-05 529507005791 HMMPfam hit to PF01035, 6-O-methylguanine DNA methyltransfera, score 4.7e-45 529507005792 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 529507005793 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 529507005794 HMMPfam hit to PF06164, Bacterial protein of unknown function (DUF97, score 6.9e-50 529507005795 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 529507005796 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 529507005797 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 529507005798 HMMPfam hit to PF00005, ABC transporter, score 7.9e-34 529507005799 PS00211 ABC transporters family signature. 529507005800 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005801 HMMPfam hit to PF00005, ABC transporter, score 8e-40 529507005802 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005803 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 529507005804 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 529507005805 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 529507005806 HMMPfam hit to PF01820, D-ala D-ala ligase N-terminus, score 4.2e-54 529507005807 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005808 PS00843 D-alanine--D-alanine ligase signature 1. 529507005809 HMMPfam hit to PF07478, D-ala D-ala ligase C-terminus, score 2.9e-114 529507005810 PS00844 D-alanine--D-alanine ligase signature 2. 529507005811 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 529507005812 dimer interface [polypeptide binding]; other site 529507005813 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 529507005814 metal binding site [ion binding]; metal-binding site 529507005815 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 2.3e-12 529507005816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 529507005817 Signal peptide predicted for PMI1245 by SignalP 2.0 HMM (Signal peptide probability 0.725) with cleavage site probability 0.715 between residues 27 and 28 529507005818 HMMPfam hit to PF07007, Protein of unknown function (DUF1311), score 8.9e-20 529507005819 Signal peptide predicted for PMI1246 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.953 between residues 22 and 23 529507005820 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 529507005821 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 529507005822 Signal peptide predicted for PMI1247 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.822 between residues 22 and 23 529507005823 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507005824 HMMPfam hit to PF03180, NLPA lipoprotein, score 3.6e-84 529507005825 methionine gamma-lyase; Validated; Region: PRK07049 529507005826 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 529507005827 homodimer interface [polypeptide binding]; other site 529507005828 substrate-cofactor binding pocket; other site 529507005829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507005830 catalytic residue [active] 529507005831 HMMPfam hit to PF01053, Cys/Met metabolism PLP-dependent enzy, score 6.3e-103 529507005832 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 529507005833 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 529507005834 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 5e-09 529507005835 Helix-turn-helix domain; Region: HTH_18; pfam12833 529507005836 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 529507005837 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.6e-08 529507005838 putative transporter; Provisional; Region: PRK10054 529507005839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507005840 putative substrate translocation pore; other site 529507005841 12 probable transmembrane helices predicted for PMI1251 by TMHMM2.0 at aa 13-35, 45-67, 74-93, 98-120, 133-155, 165-187, 208-230, 245-264, 277-296, 300-317, 337-359 and 363-382 529507005842 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.5e-31 529507005843 Signal peptide predicted for PMI1251 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.416 between residues 24 and 25 529507005844 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 529507005845 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 529507005846 HMMPfam hit to PF03255, Acetyl co-enzyme A carboxylase carboxyltrans, score 3.8e-96 529507005847 Transcriptional regulator [Transcription]; Region: LysR; COG0583 529507005848 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507005849 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 529507005850 putative effector binding pocket; other site 529507005851 dimerization interface [polypeptide binding]; other site 529507005852 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 5.6e-20 529507005853 Predicted helix-turn-helix motif with score 1028.000, SD 2.69 at aa 18-39, sequence AQFASAARSLSMPTSNVSRAIK 529507005854 PS00044 Bacterial regulatory proteins, lysR family signature. 529507005855 HMMPfam hit to PF03466, LysR substrate binding domain, score 6e-31 529507005856 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 529507005857 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 529507005858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507005859 putative substrate translocation pore; other site 529507005860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507005861 putative substrate translocation pore; other site 529507005862 14 probable transmembrane helices predicted for PMI1254 by TMHMM2.0 at aa 7-29, 44-66, 75-94, 99-121, 134-156, 162-184, 193-215, 225-244, 266-288, 303-320, 329-348, 358-380, 401-423 and 465-487 529507005863 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.8e-61 529507005864 PS00216 Sugar transport proteins signature 1. 529507005865 Signal peptide predicted for PMI1254 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.463 between residues 29 and 30 529507005866 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 529507005867 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 529507005868 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 8.6e-18 529507005869 Predicted helix-turn-helix motif with score 1165.000, SD 3.15 at aa 39-60, sequence TTVSDIVKQAGVAKGTYYHYFT 529507005870 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 529507005871 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507005872 Walker A/P-loop; other site 529507005873 ATP binding site [chemical binding]; other site 529507005874 Q-loop/lid; other site 529507005875 ABC transporter signature motif; other site 529507005876 Walker B; other site 529507005877 D-loop; other site 529507005878 H-loop/switch region; other site 529507005879 ABC transporter; Region: ABC_tran_2; pfam12848 529507005880 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 529507005881 HMMPfam hit to PF00005, ABC transporter, score 2e-41 529507005882 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005883 PS00277 Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin signature 1. 529507005884 HMMPfam hit to PF00005, ABC transporter, score 1.3e-40 529507005885 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005886 hypothetical protein; Validated; Region: PRK00124 529507005887 HMMPfam hit to PF02639, Uncharacterized BCR, YaiI/YqxD family COG167, score 1.4e-73 529507005888 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 529507005889 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 529507005890 active site 529507005891 putative substrate binding pocket [chemical binding]; other site 529507005892 Signal peptide predicted for PMI1259 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 21 and 22 529507005893 HMMPfam hit to PF01979, Amidohydrolase family, score 9.2e-56 529507005894 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005895 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 529507005896 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507005897 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 529507005898 substrate binding pocket [chemical binding]; other site 529507005899 dimerization interface [polypeptide binding]; other site 529507005900 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix protei, score 9.2e-15 529507005901 PS00044 Bacterial regulatory proteins, lysR family signature. 529507005902 Predicted helix-turn-helix motif with score 1431.000, SD 4.06 at aa 24-45, sequence RSVTLAAKWLSISPSAVSKALA 529507005903 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 529507005904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507005905 putative substrate translocation pore; other site 529507005906 HMMPfam hit to PF00083, Sugar (and other) transporter, score 3.2e-05 529507005907 12 probable transmembrane helices predicted for PMI1261 by TMHMM2.0 at aa 13-35, 50-72, 79-98, 103-125, 138-160, 165-187, 222-244, 254-276, 283-302, 307-329, 342-364 and 369-391 529507005908 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.7e-46 529507005909 PS00216 Sugar transport proteins signature 1. 529507005910 Predicted helix-turn-helix motif with score 998.000, SD 2.59 at aa 33-54, sequence TGLTAIASDLNASEVTLHHAFS 529507005911 Signal peptide predicted for PMI1261 by SignalP 2.0 HMM (Signal peptide probability 0.703) with cleavage site probability 0.558 between residues 30 and 31 529507005912 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 529507005913 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 529507005914 active site residue [active] 529507005915 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005916 Signal peptide predicted for PMI1263 by SignalP 2.0 HMM (Signal peptide probability 0.969) with cleavage site probability 0.873 between residues 26 and 27 529507005917 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507005918 2 probable transmembrane helices predicted for PMI1263 by TMHMM2.0 at aa 38-60 and 70-92 529507005919 multidrug resistance protein MdtN; Provisional; Region: PRK10476 529507005920 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 529507005921 HlyD family secretion protein; Region: HlyD_3; pfam13437 529507005922 Signal peptide predicted for PMI1264 by SignalP 2.0 HMM (Signal peptide probability 0.861) with cleavage site probability 0.449 between residues 38 and 39 529507005923 1 probable transmembrane helix predicted for PMI1264 by TMHMM2.0 at aa 12-34 529507005924 HMMPfam hit to PF00529, HlyD family secretion protein, score 1.3e-26 529507005925 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 529507005926 10 probable transmembrane helices predicted for PMI1265 by TMHMM2.0 at aa 30-52, 67-89, 96-118, 150-172, 334-353, 357-374, 381-403, 408-427, 432-449 and 464-486 529507005927 HMMPfam hit to PF04632, Fusaric acid resistance protein conserved re, score 2.1e-13 529507005928 Signal peptide predicted for PMI1266 by SignalP 2.0 HMM (Signal peptide probability 0.646) with cleavage site probability 0.185 between residues 36 and 37 529507005929 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 529507005930 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507005931 HMMPfam hit to PF02321, Outer membrane efflux protein, score 3.3e-26 529507005932 HMMPfam hit to PF02321, Outer membrane efflux protein, score 5.5e-21 529507005933 2 probable transmembrane helices predicted for PMI1267 by TMHMM2.0 at aa 9-28 and 62-84 529507005934 putative chaperone; Provisional; Region: PRK11678 529507005935 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 529507005936 nucleotide binding site [chemical binding]; other site 529507005937 putative NEF/HSP70 interaction site [polypeptide binding]; other site 529507005938 SBD interface [polypeptide binding]; other site 529507005939 PS00329 Heat shock hsp70 proteins family signature 2. 529507005940 PS00017 ATP/GTP-binding site motif A (P-loop). 529507005941 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 529507005942 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 529507005943 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 529507005944 catalytic residue [active] 529507005945 HMMPfam hit to PF01212, Beta-eliminating lyase, score 1.1e-20 529507005946 YjbD family (DUF3811); Region: DUF3811; cl08125 529507005947 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 529507005948 5 probable transmembrane helices predicted for PMI1271 by TMHMM2.0 at aa 5-27, 42-64, 71-88, 143-165 and 178-197 529507005949 HMMPfam hit to PF01810, LysE type translocator, score 1.9e-10 529507005950 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 529507005951 xylulokinase; Provisional; Region: PRK15027 529507005952 N- and C-terminal domain interface [polypeptide binding]; other site 529507005953 active site 529507005954 MgATP binding site [chemical binding]; other site 529507005955 catalytic site [active] 529507005956 metal binding site [ion binding]; metal-binding site 529507005957 xylulose binding site [chemical binding]; other site 529507005958 homodimer interface [polypeptide binding]; other site 529507005959 HMMPfam hit to PF02782, FGGY family of carbohydrate kinases, C-termi, score 8.1e-79 529507005960 PS00445 FGGY family of carbohydrate kinases signature 2. 529507005961 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 529507005962 HMMPfam hit to PF00370, FGGY family of carbohydrate kinases, N-termi, score 3.5e-115 529507005963 PS00933 FGGY family of carbohydrate kinases signature 1. 529507005964 xylose isomerase; Provisional; Region: PRK05474 529507005965 xylose isomerase; Region: xylose_isom_A; TIGR02630 529507005966 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 1e-11 529507005967 PS00172 Xylose isomerase signature 1. 529507005968 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 529507005969 HMMPfam hit to PF03553, Na+/H+ antiporter family, score 2.6e-70 529507005970 11 probable transmembrane helices predicted for PMI1274 by TMHMM2.0 at aa 13-35, 40-59, 80-102, 112-134, 141-163, 196-218, 239-258, 263-285, 327-349, 364-386 and 438-460 529507005971 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 529507005972 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 529507005973 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507005974 homodimer interface [polypeptide binding]; other site 529507005975 catalytic residue [active] 529507005976 HMMPfam hit to PF00155, Aminotransferase class I and II, score 2.4e-10 529507005977 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 529507005978 putative dimerization interface [polypeptide binding]; other site 529507005979 Transcriptional regulators [Transcription]; Region: PurR; COG1609 529507005980 putative ligand binding site [chemical binding]; other site 529507005981 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 529507005982 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 529507005983 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 0.26 529507005984 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 0.0006 529507005985 Predicted helix-turn-helix motif with score 1273.000, SD 3.52 at aa 304-325, sequence IKTEQVLDAVNMSRSNLEQRFK 529507005986 PS00041 Bacterial regulatory proteins, araC family signature. 529507005987 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 2.2e-14 529507005988 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 529507005989 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 529507005990 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 529507005991 1 probable transmembrane helix predicted for PMI1278 by TMHMM2.0 at aa 7-29 529507005992 This region appears to be originated from a mobile element 529507005993 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 529507005994 HMMPfam hit to PF03992, Antibiotic biosynthesis monooxygenase, score 3.8e-05 529507005995 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 529507005996 HMMPfam hit to PF01022, Bacterial regulatory protein, arsR family, score 1.5e-10 529507005997 Predicted helix-turn-helix motif with score 1092.000, SD 2.91 at aa 43-64, sequence WTATELSIVADISASTTSSHLS 529507005998 4 probable transmembrane helices predicted for PMI1281 by TMHMM2.0 at aa 7-29, 49-68, 75-97 and 117-139 529507005999 Signal peptide predicted for PMI1281 by SignalP 2.0 HMM (Signal peptide probability 0.622) with cleavage site probability 0.253 between residues 40 and 41 529507006000 Signal peptide predicted for PMI1283 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.970 between residues 22 and 23 529507006001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 529507006002 Coenzyme A binding pocket [chemical binding]; other site 529507006003 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.4e-06 529507006004 2 probable transmembrane helices predicted for PMI1285 by TMHMM2.0 at aa 9-31 and 46-65 529507006005 lipoprotein; Provisional; Region: PRK10540 529507006006 Signal peptide predicted for PMI1286 by SignalP 2.0 HMM (Signal peptide probability 0.981) with cleavage site probability 0.244 between residues 28 and 29 529507006007 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507006008 2 probable transmembrane helices predicted for PMI1287 by TMHMM2.0 at aa 21-40 and 44-66 529507006009 malonic semialdehyde reductase; Provisional; Region: PRK10538 529507006010 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 529507006011 putative NAD(P) binding site [chemical binding]; other site 529507006012 homodimer interface [polypeptide binding]; other site 529507006013 homotetramer interface [polypeptide binding]; other site 529507006014 active site 529507006015 HMMPfam hit to PF00106, short chain dehydrogenase, score 4.3e-63 529507006016 PS00061 Short-chain dehydrogenases/reductases family signature. 529507006017 hypothetical protein; Provisional; Region: PRK13659 529507006018 Signal peptide predicted for PMI1289 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.941 between residues 31 and 32 529507006019 HMMPfam hit to PF06932, Protein of unknown function (DUF1283), score 1.3e-31 529507006020 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 529507006021 HMMPfam hit to PF06649, Protein of unknown function (DUF1161), score 2e-31 529507006022 Signal peptide predicted for PMI1290 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.547 between residues 19 and 20 529507006023 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 529507006024 AAA domain; Region: AAA_26; pfam13500 529507006025 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 9.9e-17 529507006026 MarR family; Region: MarR_2; cl17246 529507006027 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 529507006028 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 529507006029 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 529507006030 HMMPfam hit to PF00480, ROK family, score 2.8e-10 529507006031 PS00017 ATP/GTP-binding site motif A (P-loop). 529507006032 Transcriptional regulator [Transcription]; Region: LysR; COG0583 529507006033 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507006034 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 529507006035 dimerization interface [polypeptide binding]; other site 529507006036 substrate binding pocket [chemical binding]; other site 529507006037 HMMPfam hit to PF03466, LysR substrate binding domain, score 4e-43 529507006038 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 9.4e-23 529507006039 PS00044 Bacterial regulatory proteins, lysR family signature. 529507006040 Predicted helix-turn-helix motif with score 1801.000, SD 5.32 at aa 18-39, sequence LHFGKAAERLNISQPPLSQQIQ 529507006041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507006042 Major Facilitator Superfamily; Region: MFS_1; pfam07690 529507006043 putative substrate translocation pore; other site 529507006044 HMMPfam hit to PF00083, Sugar (and other) transporter, score 8e-05 529507006045 12 probable transmembrane helices predicted for PMI1294 by TMHMM2.0 at aa 38-60, 75-97, 110-129, 133-155, 162-184, 194-216, 245-267, 277-294, 306-328, 333-355, 368-390 and 394-416 529507006046 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.3e-44 529507006047 PS00216 Sugar transport proteins signature 1. 529507006048 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 529507006049 HMMPfam hit to PF05472, DNA replication terminus site-binding protei, score 9.6e-133 529507006050 fumarate hydratase; Reviewed; Region: fumC; PRK00485 529507006051 Class II fumarases; Region: Fumarase_classII; cd01362 529507006052 active site 529507006053 tetramer interface [polypeptide binding]; other site 529507006054 HMMPfam hit to PF00206, Lyase, score 3.2e-187 529507006055 PS00163 Fumarate lyases signature. 529507006056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 529507006057 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 529507006058 HMMPfam hit to PF06097, Bacterial protein of unknown function (DUF94, score 1.8e-28 529507006059 Signal peptide predicted for PMI1297 by SignalP 2.0 HMM (Signal peptide probability 0.959) with cleavage site probability 0.754 between residues 19 and 20 529507006060 von Willebrand factor type A domain; Region: VWA_2; pfam13519 529507006061 1 probable transmembrane helix predicted for PMI1299 by TMHMM2.0 at aa 10-28 529507006062 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 529507006063 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 529507006064 active site 529507006065 purine riboside binding site [chemical binding]; other site 529507006066 HMMPfam hit to PF00962, Adenosine/AMP deaminase, score 2.6e-111 529507006067 PS00485 Adenosine and AMP deaminase signature. 529507006068 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 529507006069 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 529507006070 9 probable transmembrane helices predicted for PMI1301 by TMHMM2.0 at aa 13-32, 38-60, 73-95, 105-127, 134-156, 171-190, 211-230, 235-257 and 289-311 529507006071 Signal peptide predicted for PMI1301 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.825 between residues 30 and 31 529507006072 putative oxidoreductase; Provisional; Region: PRK11579 529507006073 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 529507006074 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 529507006075 HMMPfam hit to PF02894, Oxidoreductase family, C-terminal alph, score 1.2e-13 529507006076 HMMPfam hit to PF01408, Oxidoreductase family, NAD-binding Ros, score 3.3e-38 529507006077 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 529507006078 4 probable transmembrane helices predicted for PMI1303 by TMHMM2.0 at aa 20-42, 62-84, 97-116 and 126-144 529507006079 electron transport complex protein RsxA; Provisional; Region: PRK05151 529507006080 HMMPfam hit to PF02508, Rnf-Nqr subunit, membrane protein, score 2.3e-109 529507006081 6 probable transmembrane helices predicted for PMI1304 by TMHMM2.0 at aa 5-27, 37-56, 69-88, 103-125, 132-154 and 169-191 529507006082 electron transport complex protein RnfB; Provisional; Region: PRK05113 529507006083 Putative Fe-S cluster; Region: FeS; cl17515 529507006084 4Fe-4S binding domain; Region: Fer4; pfam00037 529507006085 Signal peptide predicted for PMI1305 by SignalP 2.0 HMM (Signal peptide probability 0.743) with cleavage site probability 0.333 between residues 23 and 24 529507006086 1 probable transmembrane helix predicted for PMI1305 by TMHMM2.0 at aa 4-26 529507006087 HMMPfam hit to PF04060, Fe-S cluster, score 4.1e-15 529507006088 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 1.1e-07 529507006089 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507006090 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 6.3e-06 529507006091 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507006092 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 529507006093 SLBB domain; Region: SLBB; pfam10531 529507006094 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 529507006095 HMMPfam hit to PF01512, Respiratory-chain NADH dehydrogenase, score 2.2e-72 529507006096 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.00012 529507006097 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507006098 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.00019 529507006099 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507006100 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 529507006101 HMMPfam hit to PF03116, NQR2, RnfD, RnfE family, score 1.5e-148 529507006102 9 probable transmembrane helices predicted for PMI1307 by TMHMM2.0 at aa 30-49, 53-72, 79-101, 105-127, 134-156, 222-244, 249-271, 281-303 and 310-327 529507006103 electron transport complex protein RnfG; Validated; Region: PRK01908 529507006104 Signal peptide predicted for PMI1308 by SignalP 2.0 HMM (Signal peptide probability 0.754) with cleavage site probability 0.451 between residues 28 and 29 529507006105 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507006106 1 probable transmembrane helix predicted for PMI1308 by TMHMM2.0 at aa 13-35 529507006107 PS00606 Beta-ketoacyl synthases active site. 529507006108 HMMPfam hit to PF04205, FMN-binding domain, score 8.8e-17 529507006109 electron transport complex RsxE subunit; Provisional; Region: PRK12405 529507006110 HMMPfam hit to PF02508, Rnf-Nqr subunit, membrane protein, score 1.4e-110 529507006111 Signal peptide predicted for PMI1309 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.372 between residues 38 and 39 529507006112 4 probable transmembrane helices predicted for PMI1309 by TMHMM2.0 at aa 74-96, 101-123, 136-158 and 189-211 529507006113 PS00284 Serpins signature. 529507006114 endonuclease III; Provisional; Region: PRK10702 529507006115 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 529507006116 minor groove reading motif; other site 529507006117 helix-hairpin-helix signature motif; other site 529507006118 substrate binding pocket [chemical binding]; other site 529507006119 active site 529507006120 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 529507006121 HMMPfam hit to PF00730, HhH-GPD superfamily base excision DNA repair, score 4.5e-19 529507006122 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 4.5e-06 529507006123 PS01155 Endonuclease III family signature. 529507006124 PS00764 Endonuclease III iron-sulfur binding region signature. 529507006125 exoribonuclease II; Provisional; Region: PRK05054 529507006126 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 529507006127 RNB domain; Region: RNB; pfam00773 529507006128 S1 RNA binding domain; Region: S1; pfam00575 529507006129 HMMPfam hit to PF00773, RNB-like protein, score 1.6e-95 529507006130 PS01175 Ribonuclease II family signature. 529507006131 translation initiation factor Sui1; Validated; Region: PRK06824 529507006132 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 529507006133 putative rRNA binding site [nucleotide binding]; other site 529507006134 HMMPfam hit to PF01253, Translation initiation factor SUI1, score 2e-35 529507006135 PS01118 Translation initiation factor SUI1 signature. 529507006136 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 529507006137 active site 529507006138 dimer interface [polypeptide binding]; other site 529507006139 HMMPfam hit to PF00215, Orotidine 5'-phosphate decarboxylase / HUMP, score 1.1e-87 529507006140 PS00156 Orotidine 5'-phosphate decarboxylase active site. 529507006141 tetratricopeptide repeat protein; Provisional; Region: PRK11788 529507006142 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 529507006143 binding surface 529507006144 TPR motif; other site 529507006145 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 1.5 529507006146 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.69 529507006147 Predicted membrane protein [Function unknown]; Region: COG3771 529507006148 HMMPfam hit to PF06305, Protein of unknown function (DUF1049), score 7.1e-44 529507006149 2 probable transmembrane helices predicted for PMI1315 by TMHMM2.0 at aa 5-24 and 44-66 529507006150 Signal peptide predicted for PMI1315 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.374 between residues 20 and 21 529507006151 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 529507006152 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 529507006153 active site 529507006154 HMMPfam hit to PF01569, PAP2 superfamily, score 6.1e-16 529507006155 6 probable transmembrane helices predicted for PMI1316 by TMHMM2.0 at aa 7-29, 49-68, 75-97, 157-179, 186-205 and 209-231 529507006156 Signal peptide predicted for PMI1316 by SignalP 2.0 HMM (Signal peptide probability 0.798) with cleavage site probability 0.220 between residues 23 and 24 529507006157 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 529507006158 dimerization interface [polypeptide binding]; other site 529507006159 active site 529507006160 HMMPfam hit to PF00925, GTP cyclohydrolase II, score 1e-113 529507006161 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 529507006162 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 529507006163 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507006164 HMMPfam hit to PF03180, NLPA lipoprotein, score 7.5e-120 529507006165 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 529507006166 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 529507006167 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 529507006168 putative trimer interface [polypeptide binding]; other site 529507006169 putative CoA binding site [chemical binding]; other site 529507006170 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 67 529507006171 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.2 529507006172 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.052 529507006173 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 12 529507006174 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.3 529507006175 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 21 529507006176 aconitate hydratase; Validated; Region: PRK09277 529507006177 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 529507006178 substrate binding site [chemical binding]; other site 529507006179 ligand binding site [chemical binding]; other site 529507006180 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 529507006181 substrate binding site [chemical binding]; other site 529507006182 HMMPfam hit to PF00694, Aconitase C-terminal domain, score 1.1e-63 529507006183 HMMPfam hit to PF00330, Aconitase family (aconitate hydratase), score 3e-277 529507006184 PS01244 Aconitase family signature 2. 529507006185 PS00450 Aconitase family signature 1. 529507006186 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507006187 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 529507006188 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507006189 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 529507006190 substrate binding site [chemical binding]; other site 529507006191 dimerization interface [polypeptide binding]; other site 529507006192 HMMPfam hit to PF03466, LysR substrate binding domain, score 5.6e-43 529507006193 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.1e-15 529507006194 PS00044 Bacterial regulatory proteins, lysR family signature. 529507006195 Predicted helix-turn-helix motif with score 1124.000, SD 3.02 at aa 17-38, sequence LNVSTTAERLYTSQPGISKQIR 529507006196 This region carries 5 highly similar lipoproteins 529507006197 1 probable transmembrane helix predicted for PMI1324 by TMHMM2.0 at aa 15-37 529507006198 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507006199 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507006200 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507006201 1 probable transmembrane helix predicted for PMI1326 by TMHMM2.0 at aa 4-26 529507006202 1 probable transmembrane helix predicted for PMI1327 by TMHMM2.0 at aa 15-37 529507006203 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507006204 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507006205 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 529507006206 active site flap/lid [active] 529507006207 nucleophilic elbow; other site 529507006208 catalytic triad [active] 529507006209 HMMPfam hit to PF01764, Lipase (class 3), score 3.7e-21 529507006210 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 529507006211 PS00017 ATP/GTP-binding site motif A (P-loop). 529507006212 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 529507006213 Predicted helix-turn-helix motif with score 1024.000, SD 2.67 at aa 1-22, sequence MSLTWTSWLTNTIQSDVYFLIN 529507006214 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 529507006215 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 529507006216 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 529507006217 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 529507006218 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 529507006219 HMMPfam hit to PF04524, Protein of unknown function, DUF586, score 2.7e-38 529507006220 PAAR motif; Region: PAAR_motif; pfam05488 529507006221 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 529507006222 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 529507006223 E-class dimer interface [polypeptide binding]; other site 529507006224 P-class dimer interface [polypeptide binding]; other site 529507006225 active site 529507006226 Cu2+ binding site [ion binding]; other site 529507006227 Zn2+ binding site [ion binding]; other site 529507006228 HMMPfam hit to PF00080, Copper/zinc superoxide dismutase (SODC), score 3.7e-46 529507006229 PS00332 Copper/Zinc superoxide dismutase signature 2. 529507006230 PS00087 Copper/Zinc superoxide dismutase signature 1. 529507006231 Signal peptide predicted for PMI1333 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.970 between residues 19 and 20 529507006232 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 529507006233 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 529507006234 active site 529507006235 interdomain interaction site; other site 529507006236 putative metal-binding site [ion binding]; other site 529507006237 nucleotide binding site [chemical binding]; other site 529507006238 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 529507006239 domain I; other site 529507006240 DNA binding groove [nucleotide binding] 529507006241 phosphate binding site [ion binding]; other site 529507006242 domain II; other site 529507006243 domain III; other site 529507006244 nucleotide binding site [chemical binding]; other site 529507006245 catalytic site [active] 529507006246 domain IV; other site 529507006247 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 529507006248 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 529507006249 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 529507006250 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 529507006251 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 7.1e-16 529507006252 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 7.5e-10 529507006253 HMMPfam hit to PF01131, DNA topoisomerase, score 6e-178 529507006254 PS00396 Prokaryotic DNA topoisomerase I active site. 529507006255 HMMPfam hit to PF01751, Toprim domain, score 3.9e-35 529507006256 hypothetical protein; Provisional; Region: PRK11037 529507006257 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 529507006258 putative inner membrane peptidase; Provisional; Region: PRK11778 529507006259 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 529507006260 tandem repeat interface [polypeptide binding]; other site 529507006261 oligomer interface [polypeptide binding]; other site 529507006262 active site residues [active] 529507006263 HMMPfam hit to PF01343, Peptidase family S49, score 1.3e-54 529507006264 2 probable transmembrane helices predicted for PMI1336 by TMHMM2.0 at aa 10-32 and 189-206 529507006265 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 529507006266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 529507006267 NAD(P) binding site [chemical binding]; other site 529507006268 active site 529507006269 HMMPfam hit to PF00106, short chain dehydrogenase, score 5.7e-52 529507006270 PS00061 Short-chain dehydrogenases/reductases family signature. 529507006271 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 529507006272 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 529507006273 HMMPfam hit to PF02572, ATP:corrinoid adenosyltransferase BtuR, score 2.1e-105 529507006274 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507006275 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 529507006276 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 529507006277 RNA binding surface [nucleotide binding]; other site 529507006278 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 529507006279 probable active site [active] 529507006280 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 3e-14 529507006281 PS01149 Rsu family of pseudouridine synthase signature. 529507006282 HMMPfam hit to PF01479, S4 domain, score 0.00019 529507006283 hypothetical protein; Provisional; Region: PRK11630 529507006284 HMMPfam hit to PF01300, yrdC domain, score 9e-71 529507006285 PS01147 SUA5/yciO/yrdC family signature. 529507006286 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 529507006287 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 529507006288 active site 529507006289 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 529507006290 HMMPfam hit to PF02811, PHP domain C-terminal region, score 2.3e-15 529507006291 HMMPfam hit to PF02231, PHP domain N-terminal region, score 4.3e-22 529507006292 anthranilate synthase component I; Provisional; Region: PRK13564 529507006293 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 529507006294 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 529507006295 HMMPfam hit to PF04715, Anthranilate synthase component I, N, score 3.8e-21 529507006296 PS00012 Phosphopantetheine attachment site. 529507006297 HMMPfam hit to PF00425, chorismate binding enzyme, score 1.1e-147 529507006298 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 529507006299 Glutamine amidotransferase class-I; Region: GATase; pfam00117 529507006300 glutamine binding [chemical binding]; other site 529507006301 catalytic triad [active] 529507006302 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 3e-63 529507006303 PS00442 Glutamine amidotransferases class-I active site. 529507006304 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 529507006305 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 529507006306 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 529507006307 HMMPfam hit to PF02885, Glycosyl transferase family, helical, score 6.5e-24 529507006308 HMMPfam hit to PF00591, Glycosyl transferase family, a/b doma, score 3.1e-128 529507006309 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 529507006310 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 529507006311 active site 529507006312 ribulose/triose binding site [chemical binding]; other site 529507006313 phosphate binding site [ion binding]; other site 529507006314 substrate (anthranilate) binding pocket [chemical binding]; other site 529507006315 product (indole) binding pocket [chemical binding]; other site 529507006316 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 529507006317 active site 529507006318 HMMPfam hit to PF00218, Indole-3-glycerol phosphate synthase, score 3.1e-139 529507006319 PS00614 Indole-3-glycerol phosphate synthase signature. 529507006320 HMMPfam hit to PF00697, N-(5'phosphoribosyl)anthranilate (PRA) isome, score 6.4e-66 529507006321 PS00126 3'5'-cyclic nucleotide phosphodiesterases signature. 529507006322 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 529507006323 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 529507006324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507006325 catalytic residue [active] 529507006326 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 1.1e-117 529507006327 PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site. 529507006328 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507006329 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 529507006330 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 529507006331 substrate binding site [chemical binding]; other site 529507006332 active site 529507006333 catalytic residues [active] 529507006334 heterodimer interface [polypeptide binding]; other site 529507006335 HMMPfam hit to PF00290, Tryptophan synthase alpha chain, score 3.8e-129 529507006336 PS00167 Tryptophan synthase alpha chain signature. 529507006337 BON domain; Region: BON; pfam04972 529507006338 Signal peptide predicted for PMI1349 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.618 between residues 29 and 30 529507006339 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 529507006340 1 probable transmembrane helix predicted for PMI1349 by TMHMM2.0 at aa 7-29 529507006341 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507006342 HMMPfam hit to PF04972, phospholipid-binding domain, score 1.3e-13 529507006343 outer membrane protein W; Provisional; Region: PRK10959 529507006344 HMMPfam hit to PF03922, OmpW family, score 2.8e-84 529507006345 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00695 Enterobacterial virulence outer membrane protein signature 2. 529507006346 Signal peptide predicted for PMI1350 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.954 between residues 21 and 22 529507006347 Uncharacterized protein family (UPF0259); Region: UPF0259; cl11642 529507006348 HMMPfam hit to PF06790, Uncharacterised protein family (UPF0259), score 4.9e-12 529507006349 Signal peptide predicted for PMI1351 by SignalP 2.0 HMM (Signal peptide probability 0.609) with cleavage site probability 0.314 between residues 45 and 46 529507006350 5 probable transmembrane helices predicted for PMI1351 by TMHMM2.0 at aa 20-42, 85-107, 134-168, 189-208 and 223-245 529507006351 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 529507006352 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 529507006353 Sulfate transporter family; Region: Sulfate_transp; pfam00916 529507006354 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 529507006355 HMMPfam hit to PF01740, STAS domain, score 0.0016 529507006356 HMMPfam hit to PF00916, Sulfate transporter family, score 3e-61 529507006357 11 probable transmembrane helices predicted for PMI1352 by TMHMM2.0 at aa 23-45, 49-71, 76-98, 108-127, 140-162, 182-199, 211-233, 260-282, 326-348, 352-374 and 394-416 529507006358 intracellular septation protein A; Reviewed; Region: PRK00259 529507006359 HMMPfam hit to PF04279, Intracellular septation protein A, score 4.5e-76 529507006360 5 probable transmembrane helices predicted for PMI1353 by TMHMM2.0 at aa 27-49, 56-73, 83-102, 124-146 and 156-175 529507006361 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 529507006362 HMMPfam hit to PF03061, Thioesterase superfamily, score 3.7e-21 529507006363 transport protein TonB; Provisional; Region: PRK10819 529507006364 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 529507006365 HMMPfam hit to PF03544, Gram-negative bacterial tonB protein, score 8e-13 529507006366 PS00018 EF-hand calcium-binding domain. 529507006367 1 probable transmembrane helix predicted for PMI1355 by TMHMM2.0 at aa 5-27 529507006368 Signal peptide predicted for PMI1355 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.824 between residues 20 and 21 529507006369 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 529507006370 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 529507006371 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 529507006372 putative active site [active] 529507006373 catalytic site [active] 529507006374 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 529507006375 putative active site [active] 529507006376 catalytic site [active] 529507006377 2 probable transmembrane helices predicted for PMI1357 by TMHMM2.0 at aa 10-29 and 36-58 529507006378 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 2.4e-07 529507006379 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 2.7e-07 529507006380 dsDNA-mimic protein; Reviewed; Region: PRK05094 529507006381 HMMPfam hit to PF04269, Protein of unknown function, DUF440, score 2.3e-33 529507006382 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 529507006383 HMMPfam hit to PF06316, Enterobacterial Ail/Lom protein, score 1.3e-13 529507006384 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00695 Enterobacterial virulence outer membrane protein signature 2. 529507006385 Signal peptide predicted for PMI1359 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.915 between residues 23 and 24 529507006386 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 529507006387 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 529507006388 putative metal binding site [ion binding]; other site 529507006389 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 2.7e-21 529507006390 Uncharacterized conserved protein [Function unknown]; Region: COG1359 529507006391 HMMPfam hit to PF03992, Antibiotic biosynthesis monooxygenase, score 4e-18 529507006392 leucine export protein LeuE; Provisional; Region: PRK10958 529507006393 6 probable transmembrane helices predicted for PMI1362 by TMHMM2.0 at aa 20-42, 51-73, 88-110, 130-152, 172-194 and 201-220 529507006394 HMMPfam hit to PF01810, LysE type translocator, score 9.9e-51 529507006395 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 529507006396 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 529507006397 Ligand Binding Site [chemical binding]; other site 529507006398 HMMPfam hit to PF01171, PP-loop family, score 5.9e-13 529507006399 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 529507006400 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 529507006401 Cl binding site [ion binding]; other site 529507006402 oligomer interface [polypeptide binding]; other site 529507006403 HMMPfam hit to PF01544, CorA-like Mg2+ transporter protein, score 8.9e-06 529507006404 2 probable transmembrane helices predicted for PMI1364 by TMHMM2.0 at aa 267-289 and 299-321 529507006405 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 529507006406 Signal peptide predicted for PMI1365 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.698 between residues 21 and 22 529507006407 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507006408 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 529507006409 Signal peptide predicted for PMI1366 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.798 between residues 21 and 22 529507006410 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 529507006411 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 529507006412 peptide binding site [polypeptide binding]; other site 529507006413 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 6.4e-80 529507006414 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 529507006415 Signal peptide predicted for PMI1367 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 23 and 24 529507006416 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 529507006417 dimer interface [polypeptide binding]; other site 529507006418 catalytic triad [active] 529507006419 peroxidatic and resolving cysteines [active] 529507006420 HMMPfam hit to PF00578, AhpC/TSA family, score 2e-30 529507006421 PS01265 Tpx family signature. 529507006422 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 529507006423 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 529507006424 putative aromatic amino acid binding site; other site 529507006425 PAS domain; Region: PAS; smart00091 529507006426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 529507006427 Walker A motif; other site 529507006428 ATP binding site [chemical binding]; other site 529507006429 Walker B motif; other site 529507006430 arginine finger; other site 529507006431 Predicted helix-turn-helix motif with score 1652.000, SD 4.81 at aa 486-507, sequence PSTRKLAKRLGISHTAIANKLR 529507006432 PS00688 Sigma-54 interaction domain C-terminal part signature. 529507006433 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 3.7e-118 529507006434 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 529507006435 HMMPfam hit to PF01842, ACT domain, score 0.0004 529507006436 hypothetical protein; Provisional; Region: PRK05415 529507006437 Domain of unknown function (DUF697); Region: DUF697; cl12064 529507006438 HMMPfam hit to PF05128, Family of unknown function (DUF697), score 7e-168 529507006439 2 probable transmembrane helices predicted for PMI1371 by TMHMM2.0 at aa 69-88 and 98-120 529507006440 Predicted ATPase [General function prediction only]; Region: COG3106 529507006441 HMMPfam hit to PF04317, YcjX-like family, DUF463, score 4.2e-296 529507006442 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 529507006443 PS00017 ATP/GTP-binding site motif A (P-loop). 529507006444 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 529507006445 1 probable transmembrane helix predicted for PMI1373 by TMHMM2.0 at aa 22-44 529507006446 Signal peptide predicted for PMI1373 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.642 between residues 40 and 41 529507006447 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 529507006448 phage shock protein C; Region: phageshock_pspC; TIGR02978 529507006449 HMMPfam hit to PF04024, PspC domain, score 4.2e-28 529507006450 1 probable transmembrane helix predicted for PMI1374 by TMHMM2.0 at aa 37-59 529507006451 phage shock protein B; Provisional; Region: pspB; PRK09458 529507006452 HMMPfam hit to PF06667, Phage shock protein B, score 1.1e-42 529507006453 1 probable transmembrane helix predicted for PMI1375 by TMHMM2.0 at aa 4-26 529507006454 phage shock protein PspA; Provisional; Region: PRK10698 529507006455 HMMPfam hit to PF04012, PspA/IM30 family, score 4.8e-54 529507006456 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 529507006457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 529507006458 Walker A motif; other site 529507006459 ATP binding site [chemical binding]; other site 529507006460 Walker B motif; other site 529507006461 arginine finger; other site 529507006462 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 529507006463 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 2e-120 529507006464 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 529507006465 PS00688 Sigma-54 interaction domain C-terminal part signature. 529507006466 Predicted helix-turn-helix motif with score 1039.000, SD 2.73 at aa 305-326, sequence YNQKMAAEKLALSYDQLRGLIK 529507006467 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 529507006468 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 529507006469 peptide binding site [polypeptide binding]; other site 529507006470 Signal peptide predicted for PMI1378 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.980 between residues 21 and 22 529507006471 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 2.1e-78 529507006472 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 529507006473 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 529507006474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507006475 putative PBP binding loops; other site 529507006476 ABC-ATPase subunit interface; other site 529507006477 Signal peptide predicted for PMI1379 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.441 between residues 25 and 26 529507006478 5 probable transmembrane helices predicted for PMI1379 by TMHMM2.0 at aa 9-31, 80-102, 114-136, 251-273 and 286-308 529507006479 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.9e-53 529507006480 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 529507006481 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 529507006482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507006483 dimer interface [polypeptide binding]; other site 529507006484 conserved gate region; other site 529507006485 putative PBP binding loops; other site 529507006486 ABC-ATPase subunit interface; other site 529507006487 5 probable transmembrane helices predicted for PMI1380 by TMHMM2.0 at aa 28-50, 100-122, 149-171, 224-246 and 261-283 529507006488 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.7e-35 529507006489 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 529507006490 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 529507006491 Walker A/P-loop; other site 529507006492 ATP binding site [chemical binding]; other site 529507006493 Q-loop/lid; other site 529507006494 ABC transporter signature motif; other site 529507006495 Walker B; other site 529507006496 D-loop; other site 529507006497 H-loop/switch region; other site 529507006498 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 529507006499 HMMPfam hit to PF00005, ABC transporter, score 5.6e-56 529507006500 PS00017 ATP/GTP-binding site motif A (P-loop). 529507006501 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 529507006502 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 529507006503 Walker A/P-loop; other site 529507006504 ATP binding site [chemical binding]; other site 529507006505 Q-loop/lid; other site 529507006506 ABC transporter signature motif; other site 529507006507 Walker B; other site 529507006508 D-loop; other site 529507006509 H-loop/switch region; other site 529507006510 HMMPfam hit to PF00005, ABC transporter, score 3.8e-61 529507006511 PS00017 ATP/GTP-binding site motif A (P-loop). 529507006512 PS00211 ABC transporters family signature. 529507006513 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 529507006514 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 529507006515 NAD binding site [chemical binding]; other site 529507006516 homotetramer interface [polypeptide binding]; other site 529507006517 homodimer interface [polypeptide binding]; other site 529507006518 substrate binding site [chemical binding]; other site 529507006519 active site 529507006520 HMMPfam hit to PF00106, short chain dehydrogenase, score 1.3e-09 529507006521 glutathionine S-transferase; Provisional; Region: PRK10542 529507006522 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 529507006523 C-terminal domain interface [polypeptide binding]; other site 529507006524 GSH binding site (G-site) [chemical binding]; other site 529507006525 dimer interface [polypeptide binding]; other site 529507006526 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 529507006527 dimer interface [polypeptide binding]; other site 529507006528 N-terminal domain interface [polypeptide binding]; other site 529507006529 substrate binding pocket (H-site) [chemical binding]; other site 529507006530 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 3.4e-24 529507006531 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal domain, score 9.3e-20 529507006532 pyridoxamine kinase; Validated; Region: PRK05756 529507006533 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 529507006534 dimer interface [polypeptide binding]; other site 529507006535 pyridoxal binding site [chemical binding]; other site 529507006536 ATP binding site [chemical binding]; other site 529507006537 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 529507006538 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 529507006539 active site 529507006540 HIGH motif; other site 529507006541 dimer interface [polypeptide binding]; other site 529507006542 KMSKS motif; other site 529507006543 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 529507006544 RNA binding surface [nucleotide binding]; other site 529507006545 HMMPfam hit to PF01479, S4 domain, score 8.2e-06 529507006546 HMMPfam hit to PF00579, tRNA synthetases class I (W and Y), score 9.1e-126 529507006547 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 529507006548 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 529507006549 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 529507006550 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 529507006551 PS01064 Pyridoxamine 5'-phosphate oxidase signature. 529507006552 HMMPfam hit to PF01243, Pyridoxamine 5'-phosphate oxidase, score 5.8e-30 529507006553 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 529507006554 HMMPfam hit to PF03702, Uncharacterised protein family (UPF0075), score 6.1e-230 529507006555 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 529507006556 Signal peptide predicted for PMI1389 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.476 between residues 25 and 26 529507006557 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507006558 HMMPfam hit to PF05433, Rickettsia 17 kDa surface antigen, score 1e-11 529507006559 transcriptional regulator SlyA; Provisional; Region: PRK03573 529507006560 MarR family; Region: MarR; pfam01047 529507006561 HMMPfam hit to PF01047, MarR family, score 1.1e-25 529507006562 Predicted helix-turn-helix motif with score 1097.000, SD 2.92 at aa 47-68, sequence QSQIQLAKAIGIEQPSLVRTLD 529507006563 Predicted Fe-S protein [General function prediction only]; Region: COG3313 529507006564 HMMPfam hit to PF06945, Protein of unknown function (DUF1289), score 1.5e-21 529507006565 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 529507006566 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 529507006567 dimer interface [polypeptide binding]; other site 529507006568 active site 529507006569 metal binding site [ion binding]; metal-binding site 529507006570 glutathione binding site [chemical binding]; other site 529507006571 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 3.7e-44 529507006572 PS00934 Glyoxalase I signature 1. 529507006573 PS00935 Glyoxalase I signature 2. 529507006574 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 529507006575 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 529507006576 dimer interface [polypeptide binding]; other site 529507006577 catalytic site [active] 529507006578 putative active site [active] 529507006579 putative substrate binding site [chemical binding]; other site 529507006580 HMMPfam hit to PF00929, Exonuclease, score 7.1e-33 529507006581 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 529507006582 putative GSH binding site [chemical binding]; other site 529507006583 catalytic residues [active] 529507006584 HMMPfam hit to PF00462, Glutaredoxin, score 0.00013 529507006585 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507006586 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 529507006587 Predicted permeases [General function prediction only]; Region: COG0730 529507006588 Signal peptide predicted for PMI1396 by SignalP 2.0 HMM (Signal peptide probability 0.612) with cleavage site probability 0.264 between residues 18 and 19 529507006589 8 probable transmembrane helices predicted for PMI1396 by TMHMM2.0 at aa 5-36, 46-68, 75-97, 107-124, 145-167, 182-204, 216-238 and 248-270 529507006590 HMMPfam hit to PF01925, Domain of unknown function DUF81, score 1.8e-33 529507006591 PS00107 Protein kinases ATP-binding region signature. 529507006592 superoxide dismutase; Provisional; Region: PRK10543 529507006593 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 529507006594 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 529507006595 HMMPfam hit to PF00081, Iron/manganese superoxide dismutases, alpha-, score 4.4e-53 529507006596 HMMPfam hit to PF02777, Iron/manganese superoxide dismutases, C-term, score 9.5e-67 529507006597 PS00088 Manganese and iron superoxide dismutases signature. 529507006598 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 529507006599 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 529507006600 DNA binding site [nucleotide binding] 529507006601 domain linker motif; other site 529507006602 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 529507006603 dimerization interface [polypeptide binding]; other site 529507006604 ligand binding site [chemical binding]; other site 529507006605 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 3.6e-12 529507006606 Predicted helix-turn-helix motif with score 2093.000, SD 6.32 at aa 2-23, sequence ATIKDVAKRAGVSTTTVSHVIN 529507006607 PS00356 Bacterial regulatory proteins, lacI family signature. 529507006608 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 2.4e-27 529507006609 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 529507006610 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507006611 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 529507006612 dimerization interface [polypeptide binding]; other site 529507006613 HMMPfam hit to PF03466, LysR substrate binding domain, score 4.9e-28 529507006614 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.7e-18 529507006615 PS00044 Bacterial regulatory proteins, lysR family signature. 529507006616 Predicted helix-turn-helix motif with score 1104.000, SD 2.95 at aa 17-38, sequence GSFSSAAQELHRVPSAVSYTVR 529507006617 putative transporter; Provisional; Region: PRK11043 529507006618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507006619 putative substrate translocation pore; other site 529507006620 Signal peptide predicted for PMI1401 by SignalP 2.0 HMM (Signal peptide probability 0.862) with cleavage site probability 0.539 between residues 29 and 30 529507006621 12 probable transmembrane helices predicted for PMI1401 by TMHMM2.0 at aa 13-35, 50-72, 81-100, 105-127, 139-161, 166-188, 218-240, 250-272, 279-298, 308-330, 343-365 and 370-390 529507006622 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.9e-51 529507006623 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 529507006624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 529507006625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507006626 S-adenosylmethionine binding site [chemical binding]; other site 529507006627 HMMPfam hit to PF02353, Cyclopropane-fatty-acyl-phospholipid synthas, score 1.8e-77 529507006628 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 529507006629 Lumazine binding domain; Region: Lum_binding; pfam00677 529507006630 Lumazine binding domain; Region: Lum_binding; pfam00677 529507006631 HMMPfam hit to PF00677, Lumazine binding domain, score 4.5e-39 529507006632 PS00693 Riboflavin synthase alpha chain family signature. 529507006633 HMMPfam hit to PF00677, Lumazine binding domain, score 8e-35 529507006634 PS00693 Riboflavin synthase alpha chain family signature. 529507006635 multidrug efflux protein; Reviewed; Region: PRK01766 529507006636 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 529507006637 cation binding site [ion binding]; other site 529507006638 Signal peptide predicted for PMI1404 by SignalP 2.0 HMM (Signal peptide probability 0.729) with cleavage site probability 0.347 between residues 41 and 42 529507006639 12 probable transmembrane helices predicted for PMI1404 by TMHMM2.0 at aa 26-48, 63-85, 108-130, 145-164, 177-196, 200-222, 258-280, 295-317, 330-352, 367-384, 404-423 and 438-460 529507006640 HMMPfam hit to PF01554, MatE, score 9.9e-38 529507006641 HMMPfam hit to PF01554, MatE, score 7.7e-49 529507006642 pyruvate kinase; Provisional; Region: PRK09206 529507006643 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 529507006644 domain interfaces; other site 529507006645 active site 529507006646 HMMPfam hit to PF00224, Pyruvate kinase, barrel domain, score 6.1e-209 529507006647 PS00110 Pyruvate kinase active site signature. 529507006648 HMMPfam hit to PF02887, Pyruvate kinase, alpha/beta domain, score 7.4e-27 529507006649 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 529507006650 HMMPfam hit to PF00324, Amino acid permease, score 1.8e-05 529507006651 12 probable transmembrane helices predicted for PMI1406 by TMHMM2.0 at aa 43-60, 70-92, 125-147, 162-181, 188-210, 225-247, 268-290, 318-340, 365-387, 397-419, 440-462 and 477-499 529507006652 Signal peptide predicted for PMI1406 by SignalP 2.0 HMM (Signal peptide probability 0.881) with cleavage site probability 0.778 between residues 28 and 29 529507006653 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 529507006654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507006655 catalytic residue [active] 529507006656 HMMPfam hit to PF00282, Pyridoxal-dependent decarboxylase conse, score 6.7e-108 529507006657 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 529507006658 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 529507006659 active site 529507006660 HMMPfam hit to PF02275, Linear amide C-N hydrolases, choloylglycine, score 1.6e-13 529507006661 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539 529507006662 Signal peptide predicted for PMI1409 by SignalP 2.0 HMM (Signal peptide probability 0.879) with cleavage site probability 0.446 between residues 50 and 51 529507006663 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507006664 HMMPfam hit to PF04728, Repeated sequence found in lipoprotein LPP, score 0.026 529507006665 L,D-transpeptidase; Provisional; Region: PRK10190 529507006666 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 529507006667 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 529507006668 HMMPfam hit to PF03734, ErfK/YbiS/YcfS/YnhG, score 3.1e-63 529507006669 HMMPfam hit to PF01476, LysM domain, score 0.0012 529507006670 Signal peptide predicted for PMI1410 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 22 and 23 529507006671 Fe-S metabolism associated domain; Region: SufE; cl00951 529507006672 HMMPfam hit to PF02657, Fe-S metabolism associated domain, score 4.4e-39 529507006673 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 529507006674 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 529507006675 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 529507006676 catalytic residue [active] 529507006677 HMMPfam hit to PF00266, Aminotransferase class-V, score 2.2e-13 529507006678 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 529507006679 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 529507006680 FeS assembly protein SufD; Region: sufD; TIGR01981 529507006681 HMMPfam hit to PF01458, Uncharacterized protein family (UPF0051), score 9.9e-82 529507006682 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 529507006683 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 529507006684 Walker A/P-loop; other site 529507006685 ATP binding site [chemical binding]; other site 529507006686 Q-loop/lid; other site 529507006687 ABC transporter signature motif; other site 529507006688 Walker B; other site 529507006689 D-loop; other site 529507006690 H-loop/switch region; other site 529507006691 HMMPfam hit to PF00005, ABC transporter, score 5.3e-32 529507006692 PS00211 ABC transporters family signature. 529507006693 PS00017 ATP/GTP-binding site motif A (P-loop). 529507006694 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 529507006695 putative ABC transporter; Region: ycf24; CHL00085 529507006696 HMMPfam hit to PF01458, Uncharacterized protein family (UPF0051), score 3.1e-140 529507006697 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 529507006698 HMMPfam hit to PF01521, HesB-like domain, score 3.3e-39 529507006699 PS01152 Hypothetical hesB/yadR/yfhF family signature. 529507006700 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507006701 Signal peptide predicted for PMI1417 by SignalP 2.0 HMM (Signal peptide probability 0.830) with cleavage site probability 0.752 between residues 22 and 23 529507006702 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 529507006703 CoenzymeA binding site [chemical binding]; other site 529507006704 subunit interaction site [polypeptide binding]; other site 529507006705 PHB binding site; other site 529507006706 HMMPfam hit to PF03061, Thioesterase superfamily, score 1.6e-17 529507006707 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 529507006708 FAD binding domain; Region: FAD_binding_4; pfam01565 529507006709 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 529507006710 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507006711 HMMPfam hit to PF02913, FAD linked oxidases, C-terminal domain, score 4.3e-69 529507006712 HMMPfam hit to PF01565, FAD binding domain, score 1.1e-53 529507006713 PS00017 ATP/GTP-binding site motif A (P-loop). 529507006714 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 529507006715 Domain of unknown function DUF20; Region: UPF0118; pfam01594 529507006716 8 probable transmembrane helices predicted for PMI1420 by TMHMM2.0 at aa 13-30, 34-56, 63-85, 160-179, 213-235, 240-271, 278-300 and 315-337 529507006717 HMMPfam hit to PF01594, Domain of unknown function DUF20, score 1.6e-45 529507006718 phosphoenolpyruvate synthase; Validated; Region: PRK06464 529507006719 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 529507006720 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 529507006721 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 529507006722 HMMPfam hit to PF02896, PEP-utilising enzyme, TIM barrel doma, score 2.4e-51 529507006723 PS00742 PEP-utilizing enzymes signature 2. 529507006724 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile domain, score 2.8e-42 529507006725 PS00370 PEP-utilizing enzymes phosphorylation site signature. 529507006726 HMMPfam hit to PF01326, Pyruvate phosphate dikinase, PEP/pyru, score 5.9e-157 529507006727 PEP synthetase regulatory protein; Provisional; Region: PRK05339 529507006728 HMMPfam hit to PF03618, Domain of unknown function (DUF299), score 3.8e-137 529507006729 PS00017 ATP/GTP-binding site motif A (P-loop). 529507006730 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 529507006731 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 529507006732 Predicted helix-turn-helix motif with score 1114.000, SD 2.98 at aa 16-37, sequence VTPETLANELPISQEIISNITS 529507006733 HMMPfam hit to PF00793, DAHP synthetase I family, score 3.1e-152 529507006734 Hemin uptake protein hemP; Region: hemP; pfam10636 529507006735 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 529507006736 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 529507006737 N-terminal plug; other site 529507006738 ligand-binding site [chemical binding]; other site 529507006739 PS00430 TonB-dependent receptor proteins signature 1. 529507006740 Signal peptide predicted for PMI1425 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.995 between residues 32 and 33 529507006741 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 7.8e-17 529507006742 HMMPfam hit to PF00593, TonB dependent receptor, score 1.8e-17 529507006743 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 529507006744 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 529507006745 N-terminal plug; other site 529507006746 ligand-binding site [chemical binding]; other site 529507006747 Signal peptide predicted for PMI1426 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 24 and 25 529507006748 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 8.8e-24 529507006749 HMMPfam hit to PF00593, TonB dependent receptor, score 3.9e-24 529507006750 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 529507006751 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 529507006752 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 529507006753 HMMPfam hit to PF05171, Haemin-degrading family, score 1.2e-86 529507006754 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 529507006755 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 529507006756 putative hemin binding site; other site 529507006757 Signal peptide predicted for PMI1428 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 19 and 20 529507006758 HMMPfam hit to PF01497, Periplasmic binding protein, score 4.4e-43 529507006759 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 529507006760 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 529507006761 ABC-ATPase subunit interface; other site 529507006762 dimer interface [polypeptide binding]; other site 529507006763 putative PBP binding regions; other site 529507006764 Signal peptide predicted for PMI1429 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.312 between residues 28 and 29 529507006765 9 probable transmembrane helices predicted for PMI1429 by TMHMM2.0 at aa 10-32, 60-79, 89-111, 116-138, 148-170, 191-210, 237-259, 272-294 and 304-326 529507006766 HMMPfam hit to PF01032, FecCD transport family, score 8.5e-123 529507006767 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 529507006768 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 529507006769 Walker A/P-loop; other site 529507006770 ATP binding site [chemical binding]; other site 529507006771 Q-loop/lid; other site 529507006772 ABC transporter signature motif; other site 529507006773 Walker B; other site 529507006774 D-loop; other site 529507006775 H-loop/switch region; other site 529507006776 HMMPfam hit to PF00005, ABC transporter, score 7.9e-36 529507006777 PS00017 ATP/GTP-binding site motif A (P-loop). 529507006778 PS00211 ABC transporters family signature. 529507006779 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 529507006780 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 529507006781 dimerization interface [polypeptide binding]; other site 529507006782 putative DNA binding site [nucleotide binding]; other site 529507006783 putative Zn2+ binding site [ion binding]; other site 529507006784 AsnC family; Region: AsnC_trans_reg; pfam01037 529507006785 HMMPfam hit to PF01037, AsnC family, score 9.9e-39 529507006786 Predicted helix-turn-helix motif with score 1084.000, SD 2.88 at aa 23-44, sequence IQNIELAKEVGLSPSPCLRRVR 529507006787 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 529507006788 Signal peptide predicted for PMI1432 by SignalP 2.0 HMM (Signal peptide probability 0.817) with cleavage site probability 0.786 between residues 33 and 34 529507006789 5 probable transmembrane helices predicted for PMI1432 by TMHMM2.0 at aa 13-35, 45-67, 79-101, 121-143 and 156-178 529507006790 HMMPfam hit to PF01810, LysE type translocator, score 1.8e-27 529507006791 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 529507006792 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 529507006793 DNA-binding site [nucleotide binding]; DNA binding site 529507006794 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 529507006795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507006796 homodimer interface [polypeptide binding]; other site 529507006797 catalytic residue [active] 529507006798 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 4.6e-14 529507006799 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 529507006800 HMMPfam hit to PF01654, Bacterial Cytochrome Ubiquinol Oxidase, score 1.5e-218 529507006801 9 probable transmembrane helices predicted for PMI1434 by TMHMM2.0 at aa 25-47, 60-82, 102-124, 131-153, 190-212, 225-242, 327-349, 361-383 and 412-434 529507006802 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 529507006803 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 529507006804 HMMPfam hit to PF02322, Cytochrome oxidase subunit II, score 1.1e-148 529507006805 8 probable transmembrane helices predicted for PMI1435 by TMHMM2.0 at aa 7-26, 74-96, 117-139, 159-181, 194-216, 226-248, 260-282 and 302-324 529507006806 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 529507006807 Signal peptide predicted for PMI1436 by SignalP 2.0 HMM (Signal peptide probability 0.699) with cleavage site probability 0.233 between residues 46 and 47 529507006808 1 probable transmembrane helix predicted for PMI1436 by TMHMM2.0 at aa 22-44 529507006809 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 529507006810 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 529507006811 FAD binding pocket [chemical binding]; other site 529507006812 FAD binding motif [chemical binding]; other site 529507006813 phosphate binding motif [ion binding]; other site 529507006814 NAD binding pocket [chemical binding]; other site 529507006815 HMMPfam hit to PF04954, Siderophore-interacting protein, score 6.4e-44 529507006816 Protein of unknown function (DUF805); Region: DUF805; pfam05656 529507006817 HMMPfam hit to PF05656, Protein of unknown function (DUF805), score 8.9e-48 529507006818 3 probable transmembrane helices predicted for PMI1438 by TMHMM2.0 at aa 24-46, 56-78 and 90-112 529507006819 hypothetical protein; Provisional; Region: PRK10536 529507006820 HMMPfam hit to PF02562, PhoH-like protein, score 4.7e-129 529507006821 PS00017 ATP/GTP-binding site motif A (P-loop). 529507006822 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 529507006823 3 probable transmembrane helices predicted for PMI1440 by TMHMM2.0 at aa 6-28, 35-57 and 92-114 529507006824 DNA-specific endonuclease I; Provisional; Region: PRK15137 529507006825 Endonuclease I; Region: Endonuclease_1; pfam04231 529507006826 HMMPfam hit to PF04231, Endonuclease I, score 5.4e-91 529507006827 1 probable transmembrane helix predicted for PMI1441 by TMHMM2.0 at aa 7-26 529507006828 Signal peptide predicted for PMI1441 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.915 between residues 23 and 24 529507006829 hypothetical protein; Provisional; Region: PRK09917 529507006830 4 probable transmembrane helices predicted for PMI1443 by TMHMM2.0 at aa 7-29, 58-80, 92-114 and 134-156 529507006831 Uncharacterized conserved protein [Function unknown]; Region: COG2966 529507006832 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 529507006833 4 probable transmembrane helices predicted for PMI1444 by TMHMM2.0 at aa 125-147, 173-195, 202-224 and 239-261 529507006834 HMMPfam hit to PF06738, Protein of unknown function (DUF1212), score 1.1e-68 529507006835 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507006836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507006837 AAA domain; Region: AAA_21; pfam13304 529507006838 Walker A/P-loop; other site 529507006839 ATP binding site [chemical binding]; other site 529507006840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507006841 Q-loop/lid; other site 529507006842 ABC transporter signature motif; other site 529507006843 Walker B; other site 529507006844 D-loop; other site 529507006845 H-loop/switch region; other site 529507006846 PS00017 ATP/GTP-binding site motif A (P-loop). 529507006847 hypothetical protein; Provisional; Region: PRK10215 529507006848 Signal peptide predicted for PMI1448 by SignalP 2.0 HMM (Signal peptide probability 0.985) with cleavage site probability 0.400 between residues 34 and 35 529507006849 1 probable transmembrane helix predicted for PMI1448 by TMHMM2.0 at aa 10-32 529507006850 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507006851 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 529507006852 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 529507006853 Ligand Binding Site [chemical binding]; other site 529507006854 HMMPfam hit to PF00582, Universal stress protein family, score 4.4e-20 529507006855 2 probable transmembrane helices predicted for PMI1450 by TMHMM2.0 at aa 21-43 and 75-97 529507006856 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 529507006857 Ligand Binding Site [chemical binding]; other site 529507006858 HMMPfam hit to PF00582, Universal stress protein family, score 3.8e-20 529507006859 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 529507006860 putative substrate binding site [chemical binding]; other site 529507006861 putative ATP binding site [chemical binding]; other site 529507006862 HMMPfam hit to PF01256, Carbohydrate kinase, score 1.8e-52 529507006863 PS01050 Uncharacterized protein family UPF0031 signature 2. 529507006864 PS00017 ATP/GTP-binding site motif A (P-loop). 529507006865 hypothetical protein; Provisional; Region: PRK10613 529507006866 Signal peptide predicted for PMI1454 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.960 between residues 21 and 22 529507006867 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 529507006868 dimer interface [polypeptide binding]; other site 529507006869 active site 529507006870 Schiff base residues; other site 529507006871 HMMPfam hit to PF00490, Delta-aminolevulinic acid dehydratase, score 9.4e-204 529507006872 PS00169 Delta-aminolevulinic acid dehydratase active site. 529507006873 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 529507006874 nucleotide binding site/active site [active] 529507006875 catalytic residue [active] 529507006876 HMMPfam hit to PF01230, HIT domain, score 6e-14 529507006877 cytosine deaminase; Provisional; Region: PRK09230 529507006878 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 529507006879 active site 529507006880 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 529507006881 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 529507006882 Na binding site [ion binding]; other site 529507006883 putative substrate binding site [chemical binding]; other site 529507006884 12 probable transmembrane helices predicted for PMI1458 by TMHMM2.0 at aa 21-43, 53-75, 96-118, 128-150, 152-174, 194-216, 223-245, 255-277, 289-311, 321-340, 360-379 and 383-402 529507006885 HMMPfam hit to PF02133, Permease for cytosine/purines, uracil,, score 1.2e-96 529507006886 Signal peptide predicted for PMI1458 by SignalP 2.0 HMM (Signal peptide probability 0.695) with cleavage site probability 0.604 between residues 44 and 45 529507006887 choline dehydrogenase; Validated; Region: PRK02106 529507006888 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 529507006889 HMMPfam hit to PF05199, GMC oxidoreductase, score 2.2e-99 529507006890 HMMPfam hit to PF00732, GMC oxidoreductase, score 6.6e-157 529507006891 PS00624 GMC oxidoreductases signature 2. 529507006892 PS00623 GMC oxidoreductases signature 1. 529507006893 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 529507006894 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 529507006895 tetrameric interface [polypeptide binding]; other site 529507006896 NAD binding site [chemical binding]; other site 529507006897 catalytic residues [active] 529507006898 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 3.5e-239 529507006899 PS00070 Aldehyde dehydrogenases cysteine active site. 529507006900 PS00687 Aldehyde dehydrogenases glutamic acid active site. 529507006901 transcriptional regulator BetI; Validated; Region: PRK00767 529507006902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 529507006903 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 529507006904 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 529507006905 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 1.2e-13 529507006906 PS01081 Bacterial regulatory proteins, tetR family signature. 529507006907 Predicted helix-turn-helix motif with score 1464.000, SD 4.17 at aa 38-59, sequence ASIALIARKAGVSNGIISHYFR 529507006908 choline transport protein BetT; Provisional; Region: PRK09928 529507006909 Signal peptide predicted for PMI1462 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.572 between residues 46 and 47 529507006910 12 probable transmembrane helices predicted for PMI1462 by TMHMM2.0 at aa 23-45, 65-82, 103-125, 153-175, 204-226, 241-263, 270-289, 325-347, 360-379, 410-432, 459-478 and 488-507 529507006911 HMMPfam hit to PF02028, BCCT family transporter, score 5.7e-279 529507006912 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 529507006913 PS01303 BCCT family of transporters signature. 529507006914 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 529507006915 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 529507006916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507006917 homodimer interface [polypeptide binding]; other site 529507006918 catalytic residue [active] 529507006919 Signal peptide predicted for PMI1463 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.987 between residues 28 and 29 529507006920 1 probable transmembrane helix predicted for PMI1463 by TMHMM2.0 at aa 7-29 529507006921 HMMPfam hit to PF00155, Aminotransferase class I and II, score 4.3e-17 529507006922 fimbrial operon 8 529507006923 Fimbrial protein; Region: Fimbrial; cl01416 529507006924 HMMPfam hit to PF00419, Fimbrial protein, score 5.8e-31 529507006925 Signal peptide predicted for PMI1464 by SignalP 2.0 HMM (Signal peptide probability 0.856) with cleavage site probability 0.545 between residues 37 and 38 529507006926 1 probable transmembrane helix predicted for PMI1464 by TMHMM2.0 at aa 12-29 529507006927 Fimbrial protein; Region: Fimbrial; cl01416 529507006928 Fimbrial protein; Region: Fimbrial; cl01416 529507006929 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507006930 1 probable transmembrane helix predicted for PMI1465 by TMHMM2.0 at aa 12-34 529507006931 Signal peptide predicted for PMI1465 by SignalP 2.0 HMM (Signal peptide probability 0.948) with cleavage site probability 0.876 between residues 32 and 33 529507006932 outer membrane usher protein; Provisional; Region: PRK15193 529507006933 PapC N-terminal domain; Region: PapC_N; pfam13954 529507006934 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 529507006935 PapC C-terminal domain; Region: PapC_C; pfam13953 529507006936 HMMPfam hit to PF00577, Fimbrial Usher protein, score 0 529507006937 1 probable transmembrane helix predicted for PMI1466 by TMHMM2.0 at aa 7-29 529507006938 Signal peptide predicted for PMI1466 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.998 between residues 25 and 26 529507006939 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 529507006940 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 529507006941 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 529507006942 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 4.4e-16 529507006943 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 1.7e-47 529507006944 Signal peptide predicted for PMI1467 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.694 between residues 29 and 30 529507006945 1 probable transmembrane helix predicted for PMI1467 by TMHMM2.0 at aa 7-29 529507006946 Fimbrial protein; Region: Fimbrial; cl01416 529507006947 HMMPfam hit to PF00419, Fimbrial protein, score 5.1e-31 529507006948 Signal peptide predicted for PMI1468 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.898 between residues 21 and 22 529507006949 Fimbrial protein; Region: Fimbrial; cl01416 529507006950 HMMPfam hit to PF00419, Fimbrial protein, score 2e-54 529507006951 1 probable transmembrane helix predicted for PMI1469 by TMHMM2.0 at aa 7-29 529507006952 Signal peptide predicted for PMI1469 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 25 and 26 529507006953 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 529507006954 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507006955 salt bridge; other site 529507006956 non-specific DNA binding site [nucleotide binding]; other site 529507006957 sequence-specific DNA binding site [nucleotide binding]; other site 529507006958 HMMPfam hit to PF01381, Helix-turn-helix, score 1.2e-10 529507006959 Predicted helix-turn-helix motif with score 2244.000, SD 6.83 at aa 36-57, sequence MTGAELGKLLNISQQQISRYER 529507006960 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 529507006961 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 529507006962 Walker A/P-loop; other site 529507006963 ATP binding site [chemical binding]; other site 529507006964 Q-loop/lid; other site 529507006965 ABC transporter signature motif; other site 529507006966 Walker B; other site 529507006967 D-loop; other site 529507006968 H-loop/switch region; other site 529507006969 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 529507006970 HMMPfam hit to PF00005, ABC transporter, score 9.3e-64 529507006971 PS00211 ABC transporters family signature. 529507006972 PS00017 ATP/GTP-binding site motif A (P-loop). 529507006973 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 529507006974 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 529507006975 Walker A/P-loop; other site 529507006976 ATP binding site [chemical binding]; other site 529507006977 Q-loop/lid; other site 529507006978 ABC transporter signature motif; other site 529507006979 Walker B; other site 529507006980 D-loop; other site 529507006981 H-loop/switch region; other site 529507006982 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 529507006983 HMMPfam hit to PF00005, ABC transporter, score 1.3e-57 529507006984 PS00211 ABC transporters family signature. 529507006985 PS00017 ATP/GTP-binding site motif A (P-loop). 529507006986 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 529507006987 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 529507006988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507006989 dimer interface [polypeptide binding]; other site 529507006990 conserved gate region; other site 529507006991 ABC-ATPase subunit interface; other site 529507006992 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.2e-43 529507006993 6 probable transmembrane helices predicted for PMI1473 by TMHMM2.0 at aa 42-64, 109-131, 143-160, 164-183, 214-236 and 268-290 529507006994 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 529507006995 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 529507006996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507006997 dimer interface [polypeptide binding]; other site 529507006998 conserved gate region; other site 529507006999 putative PBP binding loops; other site 529507007000 ABC-ATPase subunit interface; other site 529507007001 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.4e-58 529507007002 6 probable transmembrane helices predicted for PMI1474 by TMHMM2.0 at aa 5-27, 100-122, 134-156, 171-189, 228-250 and 278-300 529507007003 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 529507007004 Signal peptide predicted for PMI1474 by SignalP 2.0 HMM (Signal peptide probability 0.889) with cleavage site probability 0.461 between residues 32 and 33 529507007005 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 529507007006 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 529507007007 peptide binding site [polypeptide binding]; other site 529507007008 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 5.5e-84 529507007009 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 529507007010 1 probable transmembrane helix predicted for PMI1475 by TMHMM2.0 at aa 9-31 529507007011 Signal peptide predicted for PMI1475 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.945 between residues 27 and 28 529507007012 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 529507007013 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 529507007014 peptide binding site [polypeptide binding]; other site 529507007015 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 1.4e-88 529507007016 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 529507007017 1 probable transmembrane helix predicted for PMI1476 by TMHMM2.0 at aa 26-45 529507007018 Signal peptide predicted for PMI1476 by SignalP 2.0 HMM (Signal peptide probability 0.621) with cleavage site probability 0.621 between residues 27 and 28 529507007019 siroheme synthase; Provisional; Region: cysG; PRK10637 529507007020 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 529507007021 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 529507007022 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 529507007023 active site 529507007024 SAM binding site [chemical binding]; other site 529507007025 homodimer interface [polypeptide binding]; other site 529507007026 HMMPfam hit to PF00590, Tetrapyrrole (Corrin/Porphyrin) Methylas, score 2.2e-83 529507007027 PS00840 Uroporphyrin-III C-methyltransferase signature 2. 529507007028 PS00839 Uroporphyrin-III C-methyltransferase signature 1. 529507007029 Predicted helix-turn-helix motif with score 1085.000, SD 2.88 at aa 149-170, sequence NSLGALAQLAGKLREQVKQRFA 529507007030 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 529507007031 nitrite reductase subunit NirD; Provisional; Region: PRK14989 529507007032 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 529507007033 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 529507007034 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 529507007035 HMMPfam hit to PF01077, Nitrite and sulphite reductase 4Fe-4S do, score 3e-43 529507007036 PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 529507007037 HMMPfam hit to PF03460, Nitrite/Sulfite reductase ferredoxin-lik, score 2.9e-19 529507007038 HMMPfam hit to PF04324, BFD-like [2Fe-2S] binding domain, score 5.2e-26 529507007039 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoredu, score 8.9e-76 529507007040 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 529507007041 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 529507007042 Signal peptide predicted for PMI1480 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 22 and 23 529507007043 1 probable transmembrane helix predicted for PMI1480 by TMHMM2.0 at aa 7-29 529507007044 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 9.3e-52 529507007045 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 529507007046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507007047 dimer interface [polypeptide binding]; other site 529507007048 conserved gate region; other site 529507007049 putative PBP binding loops; other site 529507007050 ABC-ATPase subunit interface; other site 529507007051 Signal peptide predicted for PMI1481 by SignalP 2.0 HMM (Signal peptide probability 0.878) with cleavage site probability 0.412 between residues 42 and 43 529507007052 6 probable transmembrane helices predicted for PMI1481 by TMHMM2.0 at aa 26-48, 126-148, 161-183, 220-242, 283-305 and 320-342 529507007053 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2e-41 529507007054 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 529507007055 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 529507007056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507007057 dimer interface [polypeptide binding]; other site 529507007058 conserved gate region; other site 529507007059 ABC-ATPase subunit interface; other site 529507007060 Signal peptide predicted for PMI1482 by SignalP 2.0 HMM (Signal peptide probability 0.967) with cleavage site probability 0.499 between residues 35 and 36 529507007061 6 probable transmembrane helices predicted for PMI1482 by TMHMM2.0 at aa 13-35, 81-103, 124-146, 171-193, 200-222 and 242-264 529507007062 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.2e-40 529507007063 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 529507007064 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 529507007065 Walker A/P-loop; other site 529507007066 ATP binding site [chemical binding]; other site 529507007067 Q-loop/lid; other site 529507007068 ABC transporter signature motif; other site 529507007069 Walker B; other site 529507007070 D-loop; other site 529507007071 H-loop/switch region; other site 529507007072 HMMPfam hit to PF00005, ABC transporter, score 5.6e-51 529507007073 PS00017 ATP/GTP-binding site motif A (P-loop). 529507007074 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 529507007075 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 529507007076 Walker A/P-loop; other site 529507007077 ATP binding site [chemical binding]; other site 529507007078 Q-loop/lid; other site 529507007079 ABC transporter signature motif; other site 529507007080 Walker B; other site 529507007081 D-loop; other site 529507007082 H-loop/switch region; other site 529507007083 HMMPfam hit to PF00005, ABC transporter, score 2.3e-60 529507007084 PS00017 ATP/GTP-binding site motif A (P-loop). 529507007085 PS00211 ABC transporters family signature. 529507007086 hypothetical protein; Provisional; Region: PRK11111 529507007087 6 probable transmembrane helices predicted for PMI1485 by TMHMM2.0 at aa 10-32, 53-75, 80-99, 119-141, 145-167 and 188-210 529507007088 HMMPfam hit to PF01914, MarC family integral membrane protein, score 5e-80 529507007089 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 529507007090 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 529507007091 putative catalytic cysteine [active] 529507007092 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 529507007093 putative active site [active] 529507007094 metal binding site [ion binding]; metal-binding site 529507007095 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 6.1e-229 529507007096 PS00913 Iron-containing alcohol dehydrogenases signature 1. 529507007097 PS00060 Iron-containing alcohol dehydrogenases signature 2. 529507007098 thymidine kinase; Provisional; Region: PRK04296 529507007099 HMMPfam hit to PF00265, Thymidine kinase, score 2.9e-86 529507007100 PS00603 Thymidine kinase cellular-type signature. 529507007101 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 529507007102 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 529507007103 HMMPfam hit to PF00816, H-NS histone family, score 2.5e-49 529507007104 PS00017 ATP/GTP-binding site motif A (P-loop). 529507007105 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 529507007106 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 529507007107 putative NAD(P) binding site [chemical binding]; other site 529507007108 active site 529507007109 putative substrate binding site [chemical binding]; other site 529507007110 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 1.9e-121 529507007111 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 529507007112 active site 529507007113 tetramer interface; other site 529507007114 HMMPfam hit to PF00483, Nucleotidyl transferase, score 3.4e-12 529507007115 PS00017 ATP/GTP-binding site motif A (P-loop). 529507007116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507007117 active site 529507007118 response regulator of RpoS; Provisional; Region: PRK10693 529507007119 phosphorylation site [posttranslational modification] 529507007120 intermolecular recognition site; other site 529507007121 dimerization interface [polypeptide binding]; other site 529507007122 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.1e-17 529507007123 hypothetical protein; Provisional; Region: PRK01617 529507007124 SEC-C motif; Region: SEC-C; pfam02810 529507007125 HMMPfam hit to PF02810, SEC-C motif, score 7.7e-09 529507007126 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 529507007127 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 529507007128 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 529507007129 putative active site [active] 529507007130 putative substrate binding site [chemical binding]; other site 529507007131 putative cosubstrate binding site; other site 529507007132 catalytic site [active] 529507007133 HMMPfam hit to PF01842, ACT domain, score 1e-05 529507007134 HMMPfam hit to PF00551, Formyl transferase, score 5.7e-69 529507007135 Transcriptional regulator [Transcription]; Region: LysR; COG0583 529507007136 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507007137 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix protei, score 3.4e-15 529507007138 PS00044 Bacterial regulatory proteins, lysR family signature. 529507007139 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 529507007140 putative catalytic site [active] 529507007141 putative phosphate binding site [ion binding]; other site 529507007142 active site 529507007143 metal binding site A [ion binding]; metal-binding site 529507007144 DNA binding site [nucleotide binding] 529507007145 putative AP binding site [nucleotide binding]; other site 529507007146 putative metal binding site B [ion binding]; other site 529507007147 HMMPfam hit to PF03372, Endonuclease/Exonuclease/phosphatase fa, score 3.4e-48 529507007148 PS00726 AP endonucleases family 1 signature 1. 529507007149 PS00728 AP endonucleases family 1 signature 3. 529507007150 DNA topoisomerase III; Provisional; Region: PRK07726 529507007151 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 529507007152 active site 529507007153 putative interdomain interaction site [polypeptide binding]; other site 529507007154 putative metal-binding site [ion binding]; other site 529507007155 putative nucleotide binding site [chemical binding]; other site 529507007156 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 529507007157 domain I; other site 529507007158 DNA binding groove [nucleotide binding] 529507007159 phosphate binding site [ion binding]; other site 529507007160 domain II; other site 529507007161 domain III; other site 529507007162 nucleotide binding site [chemical binding]; other site 529507007163 catalytic site [active] 529507007164 domain IV; other site 529507007165 HMMPfam hit to PF01131, DNA topoisomerase, score 2.2e-176 529507007166 PS00396 Prokaryotic DNA topoisomerase I active site. 529507007167 HMMPfam hit to PF01751, Toprim domain, score 1.2e-35 529507007168 selenophosphate synthetase; Provisional; Region: PRK00943 529507007169 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 529507007170 dimerization interface [polypeptide binding]; other site 529507007171 putative ATP binding site [chemical binding]; other site 529507007172 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 3.5e-22 529507007173 HMMPfam hit to PF00586, AIR synthase related protein, N-terminal dom, score 7.9e-27 529507007174 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507007175 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 529507007176 putative FMN binding site [chemical binding]; other site 529507007177 HMMPfam hit to PF00881, Nitroreductase family, score 2.8e-28 529507007178 protease 4; Provisional; Region: PRK10949 529507007179 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 529507007180 tandem repeat interface [polypeptide binding]; other site 529507007181 oligomer interface [polypeptide binding]; other site 529507007182 active site residues [active] 529507007183 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 529507007184 tandem repeat interface [polypeptide binding]; other site 529507007185 oligomer interface [polypeptide binding]; other site 529507007186 active site residues [active] 529507007187 1 probable transmembrane helix predicted for PMI1499 by TMHMM2.0 at aa 21-43 529507007188 HMMPfam hit to PF01343, Peptidase family S49, score 2.6e-36 529507007189 HMMPfam hit to PF01343, Peptidase family S49, score 5.3e-58 529507007190 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 529507007191 active site 529507007192 homodimer interface [polypeptide binding]; other site 529507007193 PS00144 Asparaginase / glutaminase active site signature 1. 529507007194 HMMPfam hit to PF00710, Asparaginase, score 1.9e-102 529507007195 PS00917 Asparaginase / glutaminase active site signature 2. 529507007196 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 529507007197 Isochorismatase family; Region: Isochorismatase; pfam00857 529507007198 catalytic triad [active] 529507007199 metal binding site [ion binding]; metal-binding site 529507007200 conserved cis-peptide bond; other site 529507007201 HMMPfam hit to PF00857, Isochorismatase family, score 4.2e-48 529507007202 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 529507007203 HMMPfam hit to PF07023, Protein of unknown function (DUF1315), score 6.9e-50 529507007204 SelR domain; Region: SelR; pfam01641 529507007205 methionine sulfoxide reductase B; Provisional; Region: PRK00222 529507007206 HMMPfam hit to PF01641, SelR domain, score 8.6e-73 529507007207 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 529507007208 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 529507007209 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 529507007210 HMMPfam hit to PF00044, Glyceraldehyde 3-phosphate dehydrogenase, NA, score 6.9e-100 529507007211 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 529507007212 HMMPfam hit to PF02800, Glyceraldehyde 3-phosphate dehydrogenase, C-, score 2.7e-122 529507007213 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 529507007214 active site 529507007215 phosphate binding residues; other site 529507007216 catalytic residues [active] 529507007217 HMMPfam hit to PF01263, Aldose 1-epimerase, score 4.7e-47 529507007218 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 529507007219 HMMPfam hit to PF06629, MltA-interacting protein MipA, score 7.7e-68 529507007220 Signal peptide predicted for PMI1506 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 44 and 45 529507007221 Acylphosphatase; Region: Acylphosphatase; pfam00708 529507007222 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 529507007223 HypF finger; Region: zf-HYPF; pfam07503 529507007224 HypF finger; Region: zf-HYPF; pfam07503 529507007225 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 529507007226 Fumble; Region: Fumble; cl17357 529507007227 HMMPfam hit to PF00814, Glycoprotease family, score 8.8e-11 529507007228 HMMPfam hit to PF01300, yrdC domain, score 2.6e-59 529507007229 HMMPfam hit to PF07503, HypF finger, score 8.8e-17 529507007230 HMMPfam hit to PF07503, HypF finger, score 7.6e-19 529507007231 HMMPfam hit to PF00708, Acylphosphatase, score 5e-08 529507007232 PS00150 Acylphosphatase signature 1. 529507007233 alanine racemase; Reviewed; Region: dadX; PRK03646 529507007234 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 529507007235 active site 529507007236 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 529507007237 substrate binding site [chemical binding]; other site 529507007238 catalytic residues [active] 529507007239 dimer interface [polypeptide binding]; other site 529507007240 HMMPfam hit to PF00842, Alanine racemase, C-terminal domain, score 2.9e-65 529507007241 HMMPfam hit to PF01168, Alanine racemase, N-terminal domain, score 2.6e-63 529507007242 PS00395 Alanine racemase pyridoxal-phosphate attachment site. 529507007243 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 529507007244 hydroxyglutarate oxidase; Provisional; Region: PRK11728 529507007245 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 2.8e-106 529507007246 fatty acid metabolism regulator; Provisional; Region: PRK04984 529507007247 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 529507007248 DNA-binding site [nucleotide binding]; DNA binding site 529507007249 FadR C-terminal domain; Region: FadR_C; pfam07840 529507007250 HMMPfam hit to PF07840, FadR C-terminal domain, score 7.8e-109 529507007251 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 3.3e-24 529507007252 PS00043 Bacterial regulatory proteins, gntR family signature. 529507007253 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 529507007254 HMMPfam hit to PF06450, Bacterial Na+/H+ antiporter B (NhaB), score 0 529507007255 11 probable transmembrane helices predicted for PMI1511 by TMHMM2.0 at aa 20-39, 43-65, 96-118, 144-166, 199-221, 239-261, 301-332, 347-369, 390-412, 454-473 and 480-499 529507007256 disulfide bond formation protein B; Provisional; Region: PRK01749 529507007257 HMMPfam hit to PF02600, Disulfide bond formation protein DsbB, score 2.4e-51 529507007258 3 probable transmembrane helices predicted for PMI1512 by TMHMM2.0 at aa 17-39, 49-66 and 150-172 529507007259 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 529507007260 Domain of unknown function (DUF333); Region: DUF333; pfam03891 529507007261 Signal peptide predicted for PMI1513 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.766 between residues 29 and 30 529507007262 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507007263 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 529507007264 4 probable transmembrane helices predicted for PMI1514 by TMHMM2.0 at aa 4-23, 30-47, 57-79 and 86-105 529507007265 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 3.6e-40 529507007266 putative arabinose transporter; Provisional; Region: PRK03545 529507007267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507007268 putative substrate translocation pore; other site 529507007269 12 probable transmembrane helices predicted for PMI1515 by TMHMM2.0 at aa 20-42, 57-79, 86-105, 110-132, 145-167, 172-194, 215-237, 252-274, 281-300, 305-327, 339-361 and 371-390 529507007270 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 7.5e-45 529507007271 1 probable transmembrane helix predicted for PMI1516 by TMHMM2.0 at aa 13-35 529507007272 Domain of unknown function (DUF305); Region: DUF305; cl17794 529507007273 Signal peptide predicted for PMI1517 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.865 between residues 22 and 23 529507007274 HMMPfam hit to PF03713, Domain of unknown function (DUF305), score 5.9e-23 529507007275 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 529507007276 HMMPfam hit to PF03824, High-affinity nickel-transport protein, score 6.8e-46 529507007277 7 probable transmembrane helices predicted for PMI1518 by TMHMM2.0 at aa 12-31, 62-84, 105-127, 147-166, 223-245, 255-277 and 298-320 529507007278 Signal peptide predicted for PMI1518 by SignalP 2.0 HMM (Signal peptide probability 0.868) with cleavage site probability 0.448 between residues 27 and 28 529507007279 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507007280 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 529507007281 HMMPfam hit to PF06226, Protein of unknown function (DUF1007), score 3.5e-47 529507007282 Signal peptide predicted for PMI1519 by SignalP 2.0 HMM (Signal peptide probability 0.971) with cleavage site probability 0.968 between residues 31 and 32 529507007283 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 529507007284 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 1.3e-42 529507007285 3 probable transmembrane helices predicted for PMI1520 by TMHMM2.0 at aa 5-27, 31-53 and 151-173 529507007286 PS00379 CDP-alcohol phosphatidyltransferases signature. 529507007287 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 529507007288 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 529507007289 GIY-YIG motif/motif A; other site 529507007290 active site 529507007291 catalytic site [active] 529507007292 putative DNA binding site [nucleotide binding]; other site 529507007293 metal binding site [ion binding]; metal-binding site 529507007294 UvrB/uvrC motif; Region: UVR; pfam02151 529507007295 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 529507007296 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 0.059 529507007297 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 0.00056 529507007298 HMMPfam hit to PF02151, UvrB/uvrC motif, score 2.1e-12 529507007299 HMMPfam hit to PF01541, GIY-YIG catalytic domain, score 4.5e-32 529507007300 response regulator; Provisional; Region: PRK09483 529507007301 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 529507007302 DNA binding residues [nucleotide binding] 529507007303 dimerization interface [polypeptide binding]; other site 529507007304 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 3.7e-21 529507007305 Predicted helix-turn-helix motif with score 1292.000, SD 3.59 at aa 165-186, sequence KKIAQIAQELNISTKTVNSYRY 529507007306 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.7e-05 529507007307 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 529507007308 dimer interface [polypeptide binding]; other site 529507007309 FMN binding site [chemical binding]; other site 529507007310 HMMPfam hit to PF00881, Nitroreductase family, score 5.7e-40 529507007311 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 529507007312 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 529507007313 putative active site [active] 529507007314 HMMPfam hit to PF03320, Bacterial fructose-1,6-bisphosphatase, gl, score 2.6e-156 529507007315 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 529507007316 active site 529507007317 substrate binding pocket [chemical binding]; other site 529507007318 homodimer interaction site [polypeptide binding]; other site 529507007319 HMMPfam hit to PF02126, Phosphotriesterase family, score 2.3e-43 529507007320 PS01322 Phosphotriesterase family signature 1. 529507007321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 529507007322 Protein of unknown function, DUF606; Region: DUF606; pfam04657 529507007323 10 probable transmembrane helices predicted for PMI1526 by TMHMM2.0 at aa 5-27, 42-59, 80-97, 102-124, 137-159, 164-186, 199-221, 231-253, 258-280 and 285-307 529507007324 HMMPfam hit to PF04657, Protein of unknown function, DUF606, score 2.4e-08 529507007325 Signal peptide predicted for PMI1526 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.717 between residues 27 and 28 529507007326 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 529507007327 HMMPfam hit to PF07090, Protein of unknown function (DUF1355), score 5.1e-169 529507007328 PS00017 ATP/GTP-binding site motif A (P-loop). 529507007329 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 529507007330 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 529507007331 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 529507007332 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 529507007333 substrate binding site [chemical binding]; other site 529507007334 dimer interface [polypeptide binding]; other site 529507007335 ATP binding site [chemical binding]; other site 529507007336 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 1.9e-72 529507007337 PS00584 pfkB family of carbohydrate kinases signature 2. 529507007338 Predicted helix-turn-helix motif with score 1194.000, SD 3.25 at aa 19-40, sequence VKVSVLAKELSVTKETIRSDLN 529507007339 Signal peptide predicted for PMI1529 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 20 and 21 529507007340 PS00017 ATP/GTP-binding site motif A (P-loop). 529507007341 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 529507007342 Zn2+ binding site [ion binding]; other site 529507007343 Mg2+ binding site [ion binding]; other site 529507007344 AAA domain; Region: AAA_33; pfam13671 529507007345 RNA ligase; Region: RNA_ligase; pfam09414 529507007346 glucose-1-dehydrogenase; Provisional; Region: PRK08936 529507007347 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 529507007348 NAD binding site [chemical binding]; other site 529507007349 homodimer interface [polypeptide binding]; other site 529507007350 active site 529507007351 HMMPfam hit to PF00106, short chain dehydrogenase, score 7.7e-88 529507007352 PS00061 Short-chain dehydrogenases/reductases family signature. 529507007353 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 529507007354 1 probable transmembrane helix predicted for PMI1533 by TMHMM2.0 at aa 5-24 529507007355 Signal peptide predicted for PMI1533 by SignalP 2.0 HMM (Signal peptide probability 0.981) with cleavage site probability 0.793 between residues 21 and 22 529507007356 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 529507007357 Signal peptide predicted for PMI1534 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.664 between residues 22 and 23 529507007358 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507007359 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507007360 non-specific DNA binding site [nucleotide binding]; other site 529507007361 salt bridge; other site 529507007362 Predicted transcriptional regulator [Transcription]; Region: COG2932 529507007363 sequence-specific DNA binding site [nucleotide binding]; other site 529507007364 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 529507007365 Catalytic site [active] 529507007366 HMMPfam hit to PF01381, Helix-turn-helix, score 6.7e-10 529507007367 Predicted helix-turn-helix motif with score 1711.000, SD 5.01 at aa 16-37, sequence LTQSELATLAGTTQQSIEQLES 529507007368 HMMPfam hit to PF00717, Peptidase S24-like, score 7.6e-12 529507007369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507007370 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 529507007371 Walker A/P-loop; other site 529507007372 ATP binding site [chemical binding]; other site 529507007373 Q-loop/lid; other site 529507007374 ABC transporter signature motif; other site 529507007375 Walker B; other site 529507007376 D-loop; other site 529507007377 H-loop/switch region; other site 529507007378 HMMPfam hit to PF00005, ABC transporter, score 2.8e-56 529507007379 PS00211 ABC transporters family signature. 529507007380 PS00017 ATP/GTP-binding site motif A (P-loop). 529507007381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507007382 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 529507007383 putative PBP binding loops; other site 529507007384 ABC-ATPase subunit interface; other site 529507007385 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.7e-15 529507007386 6 probable transmembrane helices predicted for PMI1538 by TMHMM2.0 at aa 7-29, 49-71, 83-105, 120-139, 169-191 and 226-248 529507007387 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 529507007388 Signal peptide predicted for PMI1538 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.592 between residues 22 and 23 529507007389 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 529507007390 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 529507007391 1 probable transmembrane helix predicted for PMI1539 by TMHMM2.0 at aa 5-27 529507007392 Signal peptide predicted for PMI1539 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 529507007393 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 529507007394 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 529507007395 DNA binding residues [nucleotide binding] 529507007396 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 529507007397 HMMPfam hit to PF04198, sugar-binding domain, score 7.4e-81 529507007398 Predicted helix-turn-helix motif with score 1687.000, SD 4.93 at aa 33-54, sequence LSQSEVANIMSVSRVTVVKYLH 529507007399 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091 529507007400 HMMPfam hit to PF03091, CutA1 divalent ion tolerance protein, score 1.4e-47 529507007401 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 529507007402 30S ribosomal protein subunit S22 family; Region: Ribosomal_S22; cl11579 529507007403 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 529507007404 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 529507007405 GMP synthase; Reviewed; Region: guaA; PRK00074 529507007406 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 529507007407 AMP/PPi binding site [chemical binding]; other site 529507007408 candidate oxyanion hole; other site 529507007409 catalytic triad [active] 529507007410 potential glutamine specificity residues [chemical binding]; other site 529507007411 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 529507007412 ATP Binding subdomain [chemical binding]; other site 529507007413 Ligand Binding sites [chemical binding]; other site 529507007414 Dimerization subdomain; other site 529507007415 HMMPfam hit to PF00958, GMP synthase C terminal domain, score 6.6e-73 529507007416 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 1.1e-49 529507007417 PS00442 Glutamine amidotransferases class-I active site. 529507007418 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 529507007419 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 529507007420 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 529507007421 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 529507007422 active site 529507007423 HMMPfam hit to PF00478, IMP dehydrogenase / GMP reductase domain, score 4.5e-203 529507007424 PS00487 IMP dehydrogenase / GMP reductase signature. 529507007425 HMMPfam hit to PF00571, CBS domain, score 3.2e-10 529507007426 HMMPfam hit to PF00571, CBS domain, score 4.7e-12 529507007427 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 529507007428 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 529507007429 generic binding surface II; other site 529507007430 generic binding surface I; other site 529507007431 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 1.6e-11 529507007432 HMMPfam hit to PF02601, Exonuclease VII, large subunit, score 4.3e-74 529507007433 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 529507007434 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 529507007435 HMMPfam hit to PF00593, TonB dependent receptor, score 1.2e-22 529507007436 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS01156 TonB-dependent receptor proteins signature 2. 529507007437 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 4.8e-12 529507007438 Signal peptide predicted for PMI1548 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.988 between residues 25 and 26 529507007439 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 529507007440 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 529507007441 HMMPfam hit to PF00326, Prolyl oligopeptidase family, score 1.1e-102 529507007442 PS00708 Prolyl endopeptidase family serine active site. 529507007443 HMMPfam hit to PF02897, Prolyl oligopeptidase, N-terminal beta, score 1.2e-111 529507007444 Signal peptide predicted for PMI1549 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 29 and 30 529507007445 1 probable transmembrane helix predicted for PMI1549 by TMHMM2.0 at aa 12-29 529507007446 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 529507007447 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 529507007448 1 probable transmembrane helix predicted for PMI1550 by TMHMM2.0 at aa 20-39 529507007449 Protein of unknown function, DUF399; Region: DUF399; cl01139 529507007450 HMMPfam hit to PF04187, Protein of unknown function, DUF399, score 1.2e-49 529507007451 Signal peptide predicted for PMI1551 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.629 between residues 26 and 27 529507007452 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507007453 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 529507007454 Malic enzyme, N-terminal domain; Region: malic; pfam00390 529507007455 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 529507007456 putative NAD(P) binding site [chemical binding]; other site 529507007457 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 529507007458 HMMPfam hit to PF01515, Phosphate acetyl/butaryl transferase, score 1.1e-117 529507007459 Predicted helix-turn-helix motif with score 1016.000, SD 2.65 at aa 514-535, sequence QEYYQIMKRRGVSQEQARRAVI 529507007460 HMMPfam hit to PF03949, Malic enzyme, NAD binding domain, score 1.7e-128 529507007461 HMMPfam hit to PF00390, Malic enzyme, N-terminal domain, score 1.2e-76 529507007462 transcriptional regulator NarP; Provisional; Region: PRK10403 529507007463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507007464 active site 529507007465 phosphorylation site [posttranslational modification] 529507007466 intermolecular recognition site; other site 529507007467 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 529507007468 DNA binding residues [nucleotide binding] 529507007469 dimerization interface [polypeptide binding]; other site 529507007470 HMMPfam hit to PF00072, Response regulator receiver domain, score 6.9e-31 529507007471 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 4e-24 529507007472 PS00622 Bacterial regulatory proteins, luxR family signature. 529507007473 Predicted helix-turn-helix motif with score 1585.000, SD 4.59 at aa 163-184, sequence MKNKQIAENLFISEETVKVHIR 529507007474 Signal peptide predicted for PMI1554 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 19 and 20 529507007475 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 529507007476 ArsC family; Region: ArsC; pfam03960 529507007477 putative catalytic residues [active] 529507007478 HMMPfam hit to PF03960, ArsC family, score 3.8e-42 529507007479 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 529507007480 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 529507007481 metal binding site [ion binding]; metal-binding site 529507007482 dimer interface [polypeptide binding]; other site 529507007483 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 529507007484 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 1e-39 529507007485 PS00092 N-6 Adenine-specific DNA methylases signature. 529507007486 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 1.9e-32 529507007487 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 529507007488 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 529507007489 HMMPfam hit to PF02557, D-alanyl-D-alanine carboxypeptidase, score 4.1e-08 529507007490 hypothetical protein; Provisional; Region: PRK10527 529507007491 HMMPfam hit to PF04304, Protein of unknown function (DUF454), score 7.7e-27 529507007492 3 probable transmembrane helices predicted for PMI1558 by TMHMM2.0 at aa 5-27, 78-97 and 99-118 529507007493 Signal peptide predicted for PMI1558 by SignalP 2.0 HMM (Signal peptide probability 0.968) with cleavage site probability 0.619 between residues 20 and 21 529507007494 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 529507007495 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 529507007496 Helicase; Region: Helicase_RecD; pfam05127 529507007497 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 529507007498 Coenzyme A binding pocket [chemical binding]; other site 529507007499 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 529507007500 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 6.8e-05 529507007501 HMMPfam hit to PF05127, ATPase (DUF699), score 3e-42 529507007502 PS00017 ATP/GTP-binding site motif A (P-loop). 529507007503 Protein of unknown function (DUF441); Region: DUF441; pfam04284 529507007504 HMMPfam hit to PF04284, Protein of unknown function (DUF441), score 1.2e-72 529507007505 4 probable transmembrane helices predicted for PMI1560 by TMHMM2.0 at aa 7-36, 51-73, 80-102 and 126-148 529507007506 Signal peptide predicted for PMI1560 by SignalP 2.0 HMM (Signal peptide probability 0.853) with cleavage site probability 0.542 between residues 29 and 30 529507007507 Predicted metalloprotease [General function prediction only]; Region: COG2321 529507007508 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 529507007509 HMMPfam hit to PF04228, neutral zinc metallopeptidase, score 3e-140 529507007510 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 529507007511 1 probable transmembrane helix predicted for PMI1561 by TMHMM2.0 at aa 41-63 529507007512 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 529507007513 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 529507007514 ATP binding site [chemical binding]; other site 529507007515 active site 529507007516 substrate binding site [chemical binding]; other site 529507007517 HMMPfam hit to PF01259, SAICAR synthetase, score 6.3e-110 529507007518 PS01058 SAICAR synthetase signature 2. 529507007519 PS01057 SAICAR synthetase signature 1. 529507007520 lipoprotein; Provisional; Region: PRK11679 529507007521 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 529507007522 HMMPfam hit to PF06804, NlpB/DapX lipoprotein, score 2e-131 529507007523 Signal peptide predicted for PMI1563 by SignalP 2.0 HMM (Signal peptide probability 0.973) with cleavage site probability 0.293 between residues 26 and 27 529507007524 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507007525 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 529507007526 dihydrodipicolinate synthase; Region: dapA; TIGR00674 529507007527 dimer interface [polypeptide binding]; other site 529507007528 active site 529507007529 catalytic residue [active] 529507007530 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase family, score 2.6e-153 529507007531 PS00666 Dihydrodipicolinate synthetase signature 2. 529507007532 PS00665 Dihydrodipicolinate synthetase signature 1. 529507007533 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 529507007534 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 529507007535 ACT domain; Region: ACT_5; pfam13710 529507007536 HMMPfam hit to PF01842, ACT domain, score 0.00026 529507007537 HMMPfam hit to PF01842, ACT domain, score 0.00061 529507007538 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 529507007539 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 529507007540 catalytic triad [active] 529507007541 HMMPfam hit to PF00578, AhpC/TSA family, score 8.9e-63 529507007542 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 529507007543 Domain of unknown function DUF20; Region: UPF0118; pfam01594 529507007544 HMMPfam hit to PF01594, Domain of unknown function DUF20, score 6e-87 529507007545 7 probable transmembrane helices predicted for PMI1567 by TMHMM2.0 at aa 21-52, 67-89, 153-175, 217-234, 241-263, 278-297 and 310-332 529507007546 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 529507007547 Peptidase family M48; Region: Peptidase_M48; pfam01435 529507007548 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 529507007549 TPR motif; other site 529507007550 binding surface 529507007551 Signal peptide predicted for PMI1568 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 27 and 28 529507007552 HMMPfam hit to PF01435, Peptidase family M48, score 2e-30 529507007553 HMMPfam hit to PF07719, no description, score 2.1 529507007554 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 529507007555 ArsC family; Region: ArsC; pfam03960 529507007556 catalytic residues [active] 529507007557 HMMPfam hit to PF03960, ArsC family, score 1.6e-40 529507007558 nucleoside transporter; Region: 2A0110; TIGR00889 529507007559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507007560 putative substrate translocation pore; other site 529507007561 HMMPfam hit to PF03825, Nucleoside H+ symporter, score 4.3e-131 529507007562 HMMPfam hit to PF01306, LacY proton/sugar symporter, score 3.2e-05 529507007563 12 probable transmembrane helices predicted for PMI1570 by TMHMM2.0 at aa 12-34, 49-71, 78-100, 105-127, 144-166, 171-190, 221-243, 263-285, 292-311, 321-343, 356-378 and 393-415 529507007564 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.3e-16 529507007565 DNA replication initiation factor; Provisional; Region: PRK08084 529507007566 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 529507007567 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 529507007568 Mechanosensitive ion channel; Region: MS_channel; pfam00924 529507007569 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 7.9e-24 529507007570 4 probable transmembrane helices predicted for PMI1572 by TMHMM2.0 at aa 15-37, 94-116, 131-153 and 158-180 529507007571 uracil transporter; Provisional; Region: PRK10720 529507007572 12 probable transmembrane helices predicted for PMI1573 by TMHMM2.0 at aa 20-39, 44-61, 68-85, 89-111, 116-138, 158-180, 185-207, 227-249, 304-326, 331-353, 365-387 and 392-411 529507007573 HMMPfam hit to PF00860, Permease family, score 1e-128 529507007574 PS01116 Xanthine/uracil permeases family signature. 529507007575 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 529507007576 active site 529507007577 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 1.3e-13 529507007578 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 529507007579 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 529507007580 dimerization interface [polypeptide binding]; other site 529507007581 putative ATP binding site [chemical binding]; other site 529507007582 HMMPfam hit to PF00586, AIR synthase related protein, N-terminal dom, score 6.1e-75 529507007583 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 1.7e-45 529507007584 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 529507007585 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 529507007586 active site 529507007587 substrate binding site [chemical binding]; other site 529507007588 cosubstrate binding site; other site 529507007589 catalytic site [active] 529507007590 HMMPfam hit to PF00551, Formyl transferase, score 4.2e-80 529507007591 PS00373 Phosphoribosylglycinamide formyltransferase active site. 529507007592 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 529507007593 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 529507007594 Coenzyme A binding pocket [chemical binding]; other site 529507007595 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 6.2e-20 529507007596 polyphosphate kinase; Provisional; Region: PRK05443 529507007597 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 529507007598 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 529507007599 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 529507007600 domain interface [polypeptide binding]; other site 529507007601 active site 529507007602 catalytic site [active] 529507007603 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 529507007604 domain interface [polypeptide binding]; other site 529507007605 active site 529507007606 catalytic site [active] 529507007607 HMMPfam hit to PF02503, Polyphosphate kinase, score 0 529507007608 exopolyphosphatase; Provisional; Region: PRK10854 529507007609 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 529507007610 HMMPfam hit to PF02541, Ppx/GppA phosphatase family, score 3.1e-114 529507007611 Predicted helix-turn-helix motif with score 1191.000, SD 3.24 at aa 320-341, sequence RTAKSLAEHYNIDREQAKRVLT 529507007612 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 529507007613 MgtE intracellular N domain; Region: MgtE_N; smart00924 529507007614 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 529507007615 Divalent cation transporter; Region: MgtE; cl00786 529507007616 HMMPfam hit to PF03448, MgtE intracellular domain, score 2.3e-33 529507007617 HMMPfam hit to PF00571, CBS domain, score 0.22 529507007618 HMMPfam hit to PF00571, CBS domain, score 8.4e-06 529507007619 HMMPfam hit to PF01769, Divalent cation transporter, score 4.4e-13 529507007620 3 probable transmembrane helices predicted for PMI1580 by TMHMM2.0 at aa 398-420, 427-449 and 464-486 529507007621 metabolite-proton symporter; Region: 2A0106; TIGR00883 529507007622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507007623 HMMPfam hit to PF00083, Sugar (and other) transporter, score 1.1e-19 529507007624 12 probable transmembrane helices predicted for PMI1581 by TMHMM2.0 at aa 26-48, 63-85, 98-120, 130-152, 164-186, 199-221, 253-275, 290-312, 319-338, 348-370, 383-405 and 415-437 529507007625 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.6e-12 529507007626 RES domain; Region: RES; pfam08808 529507007627 PS00017 ATP/GTP-binding site motif A (P-loop). 529507007628 Predicted helix-turn-helix motif with score 1534.000, SD 4.41 at aa 96-117, sequence CRASQAAAILGVKRQTINNRLK 529507007629 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 529507007630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507007631 putative substrate translocation pore; other site 529507007632 POT family; Region: PTR2; pfam00854 529507007633 13 probable transmembrane helices predicted for PMI1584 by TMHMM2.0 at aa 60-82, 91-108, 118-140, 153-175, 179-201, 222-241, 245-263, 276-293, 328-345, 352-374, 384-406, 419-441 and 461-483 529507007634 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 6.2e-13 529507007635 HMMPfam hit to PF00854, POT family, score 1.7e-104 529507007636 PS01023 PTR2 family proton/oligopeptide symporters signature 2. 529507007637 PS01022 PTR2 family proton/oligopeptide symporters signature 1. 529507007638 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 529507007639 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 529507007640 HlyD family secretion protein; Region: HlyD_3; pfam13437 529507007641 Signal peptide predicted for PMI1585 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.613 between residues 26 and 27 529507007642 1 probable transmembrane helix predicted for PMI1585 by TMHMM2.0 at aa 13-30 529507007643 HMMPfam hit to PF00529, HlyD family secretion protein, score 8.5e-20 529507007644 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 529507007645 Protein export membrane protein; Region: SecD_SecF; cl14618 529507007646 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 529507007647 11 probable transmembrane helices predicted for PMI1586 by TMHMM2.0 at aa 15-37, 343-362, 366-388, 395-417, 437-459, 472-494, 535-557, 867-889, 909-931, 968-990 and 1000-1022 529507007648 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 529507007649 Protein export membrane protein; Region: SecD_SecF; cl14618 529507007650 Signal peptide predicted for PMI1587 by SignalP 2.0 HMM (Signal peptide probability 0.917) with cleavage site probability 0.201 between residues 35 and 36 529507007651 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 529507007652 10 probable transmembrane helices predicted for PMI1587 by TMHMM2.0 at aa 12-34, 336-353, 360-382, 428-450, 463-485, 528-547, 853-875, 895-917, 949-971 and 986-1008 529507007653 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 529507007654 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 529507007655 dimerization interface [polypeptide binding]; other site 529507007656 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 529507007657 dimer interface [polypeptide binding]; other site 529507007658 phosphorylation site [posttranslational modification] 529507007659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 529507007660 ATP binding site [chemical binding]; other site 529507007661 Mg2+ binding site [ion binding]; other site 529507007662 G-X-G motif; other site 529507007663 Signal peptide predicted for PMI1588 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.806 between residues 31 and 32 529507007664 2 probable transmembrane helices predicted for PMI1588 by TMHMM2.0 at aa 7-26 and 160-182 529507007665 HMMPfam hit to PF00672, HAMP domain, score 7.6e-20 529507007666 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 3.5e-14 529507007667 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 3.8e-30 529507007668 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 529507007669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507007670 active site 529507007671 phosphorylation site [posttranslational modification] 529507007672 intermolecular recognition site; other site 529507007673 dimerization interface [polypeptide binding]; other site 529507007674 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 529507007675 DNA binding site [nucleotide binding] 529507007676 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.1e-33 529507007677 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 1.3e-21 529507007678 putative protease; Provisional; Region: PRK15452 529507007679 Peptidase family U32; Region: Peptidase_U32; pfam01136 529507007680 HMMPfam hit to PF01136, Peptidase family U32, score 5.8e-148 529507007681 PS01276 Peptidase family U32 signature. 529507007682 lipid kinase; Reviewed; Region: PRK13054 529507007683 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 529507007684 HMMPfam hit to PF00781, Diacylglycerol kinase catalytic domain (pres, score 1.1e-28 529507007685 PS00217 Sugar transport proteins signature 2. 529507007686 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 529507007687 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 529507007688 putative active site; other site 529507007689 catalytic residue [active] 529507007690 HMMPfam hit to PF01791, Deoxyribose-phosphate aldolase, score 3.3e-120 529507007691 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 529507007692 dimer interface [polypeptide binding]; other site 529507007693 substrate binding site [chemical binding]; other site 529507007694 ATP binding site [chemical binding]; other site 529507007695 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 529507007696 Signal peptide predicted for PMI1595 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 33 and 34 529507007697 HMMPfam hit to PF07017, Antimicrobial peptide resistance and lipid A, score 3.6e-93 529507007698 aromatic amino acid transporter; Provisional; Region: PRK10238 529507007699 HMMPfam hit to PF00324, Amino acid permease, score 1.6e-147 529507007700 12 probable transmembrane helices predicted for PMI1596 by TMHMM2.0 at aa 27-46, 50-72, 92-114, 129-151, 160-182, 202-224, 245-267, 287-309, 336-358, 362-384, 404-426 and 430-448 529507007701 PS00218 Amino acid permeases signature. 529507007702 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 529507007703 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 529507007704 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.7e-08 529507007705 Predicted helix-turn-helix motif with score 1080.000, SD 2.87 at aa 25-46, sequence IHLEELAAYSGYSLWHMQKIFK 529507007706 PS00041 Bacterial regulatory proteins, araC family signature. 529507007707 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 4.9e-12 529507007708 sugar phosphate phosphatase; Provisional; Region: PRK10513 529507007709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 529507007710 active site 529507007711 motif I; other site 529507007712 motif II; other site 529507007713 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 529507007714 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 2.6e-09 529507007715 PS01228 Hypothetical cof family signature 1. 529507007716 PS01229 Hypothetical cof family signature 2. 529507007717 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 529507007718 Signal peptide predicted for PMI1599 by SignalP 2.0 HMM (Signal peptide probability 0.928) with cleavage site probability 0.418 between residues 21 and 22 529507007719 HMMPfam hit to PF05525, Branched-chain amino acid transport p, score 3.7e-167 529507007720 12 probable transmembrane helices predicted for PMI1599 by TMHMM2.0 at aa 7-29, 39-61, 73-95, 117-136, 143-165, 191-213, 234-256, 282-304, 317-336, 340-362, 374-392 and 414-436 529507007721 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 529507007722 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 529507007723 amidase catalytic site [active] 529507007724 Zn binding residues [ion binding]; other site 529507007725 substrate binding site [chemical binding]; other site 529507007726 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 529507007727 HMMPfam hit to PF01510, N-acetylmuramoyl-L-alanine amidase, score 8.1e-31 529507007728 Signal peptide predicted for PMI1600 by SignalP 2.0 HMM (Signal peptide probability 0.804) with cleavage site probability 0.460 between residues 22 and 23 529507007729 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507007730 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 529507007731 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 529507007732 HMMPfam hit to PF01235, Sodium:alanine symporter family, score 2.9e-218 529507007733 10 probable transmembrane helices predicted for PMI1601 by TMHMM2.0 at aa 13-35, 80-102, 141-163, 178-200, 207-224, 234-256, 302-324, 344-366, 387-409 and 419-436 529507007734 PS00873 Sodium:alanine symporter family signature. 529507007735 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 529507007736 HMMPfam hit to PF06440, DNA polymerase III, theta subunit, score 9.3e-37 529507007737 YebF-like protein; Region: YebF; pfam13995 529507007738 Signal peptide predicted for PMI1603 by SignalP 2.0 HMM (Signal peptide probability 0.718) with cleavage site probability 0.708 between residues 27 and 28 529507007739 hypothetical protein; Provisional; Region: PRK05114 529507007740 HMMPfam hit to PF03701, Uncharacterised protein family (UPF0181), score 1.1e-29 529507007741 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 529507007742 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 529507007743 chorismate binding enzyme; Region: Chorismate_bind; cl10555 529507007744 HMMPfam hit to PF04715, Anthranilate synthase component I, N, score 1.1e-26 529507007745 HMMPfam hit to PF00425, chorismate binding enzyme, score 1e-124 529507007746 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 529507007747 putative active site [active] 529507007748 putative CoA binding site [chemical binding]; other site 529507007749 nudix motif; other site 529507007750 metal binding site [ion binding]; metal-binding site 529507007751 HMMPfam hit to PF00293, NUDIX domain, score 1.3e-13 529507007752 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 529507007753 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 529507007754 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 529507007755 HMMPfam hit to PF03315, Serine dehydratase beta chain, score 6.7e-94 529507007756 HMMPfam hit to PF03313, Serine dehydratase alpha chain, score 1.2e-194 529507007757 hypothetical protein; Provisional; Region: PRK11469 529507007758 Domain of unknown function DUF; Region: DUF204; pfam02659 529507007759 Domain of unknown function DUF; Region: DUF204; pfam02659 529507007760 6 probable transmembrane helices predicted for PMI1608 by TMHMM2.0 at aa 20-42, 55-77, 82-104, 125-147, 152-174 and 187-209 529507007761 HMMPfam hit to PF02659, Domain of unknown function DUF, score 2.8e-26 529507007762 HMMPfam hit to PF02659, Domain of unknown function DUF, score 1.7e-21 529507007763 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 529507007764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507007765 S-adenosylmethionine binding site [chemical binding]; other site 529507007766 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 529507007767 HMMPfam hit to PF06146, Phosphate-starvation-inducible E, score 2.3e-58 529507007768 4 probable transmembrane helices predicted for PMI1610 by TMHMM2.0 at aa 21-43, 66-88, 95-112 and 122-139 529507007769 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 529507007770 Ligand Binding Site [chemical binding]; other site 529507007771 HMMPfam hit to PF00582, Universal stress protein family, score 3e-12 529507007772 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 529507007773 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 4.6e-09 529507007774 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 529507007775 Ligand Binding Site [chemical binding]; other site 529507007776 HMMPfam hit to PF00582, Universal stress protein family, score 2.5e-11 529507007777 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 529507007778 HMMPfam hit to PF00324, Amino acid permease, score 5.3e-151 529507007779 12 probable transmembrane helices predicted for PMI1614 by TMHMM2.0 at aa 21-43, 47-69, 93-115, 135-157, 162-184, 213-235, 248-270, 285-307, 342-364, 374-396, 409-431 and 441-459 529507007780 PS00218 Amino acid permeases signature. 529507007781 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 529507007782 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 529507007783 Na binding site [ion binding]; other site 529507007784 12 probable transmembrane helices predicted for PMI1615 by TMHMM2.0 at aa 13-35, 77-99, 138-160, 175-197, 202-224, 244-266, 287-309, 324-346, 382-401, 411-433, 440-458 and 462-484 529507007785 PS00457 Sodium:solute symporter family signature 2. 529507007786 HMMPfam hit to PF00474, Sodium:solute symporter family, score 3.9e-183 529507007787 PS00456 Sodium:solute symporter family signature 1. 529507007788 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 529507007789 Predicted transcriptional regulator [Transcription]; Region: COG3905 529507007790 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 529507007791 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 529507007792 Glutamate binding site [chemical binding]; other site 529507007793 NAD binding site [chemical binding]; other site 529507007794 catalytic residues [active] 529507007795 HMMPfam hit to PF01619, Proline dehydrogenase, score 4.5e-186 529507007796 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 5e-75 529507007797 PS00687 Aldehyde dehydrogenases glutamic acid active site. 529507007798 PS00070 Aldehyde dehydrogenases cysteine active site. 529507007799 flagellar locus 529507007800 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 529507007801 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like d, score 0.023 529507007802 PS00190 Cytochrome c family heme-binding site signature. 529507007803 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 529507007804 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 529507007805 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 529507007806 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 529507007807 DNA binding residues [nucleotide binding] 529507007808 HMMPfam hit to PF04545, Sigma-70, region, score 1.1e-19 529507007809 PS00716 Sigma-70 factors family signature 2. 529507007810 Predicted helix-turn-helix motif with score 1451.000, SD 4.13 at aa 209-230, sequence LNLKEIGAVLNVGESRVSQLHS 529507007811 HMMPfam hit to PF04539, Sigma-70 region, score 1.3e-20 529507007812 HMMPfam hit to PF04542, Sigma-70 region, score 2.5e-18 529507007813 PS00715 Sigma-70 factors family signature 1. 529507007814 flagellin; Validated; Region: PRK06819 529507007815 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 529507007816 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 529507007817 HMMPfam hit to PF00700, Bacterial flagellin C-terminus, score 2.3e-39 529507007818 Predicted helix-turn-helix motif with score 1004.000, SD 2.61 at aa 323-344, sequence ESRSKLGAIQNRFQSTINNLNN 529507007819 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 1.4e-80 529507007820 flagellin; Validated; Region: PRK06819 529507007821 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 529507007822 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 529507007823 HMMPfam hit to PF00700, Bacterial flagellin C-terminus, score 1.1e-39 529507007824 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 6e-82 529507007825 flagellar capping protein; Reviewed; Region: fliD; PRK08032 529507007826 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 529507007827 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 529507007828 HMMPfam hit to PF02465, Flagellar hook-associated protein, score 4.5e-35 529507007829 HMMPfam hit to PF07196, Flagellin hook IN motif, score 1.4e-10 529507007830 HMMPfam hit to PF07195, Flagellar hook-associated protein, score 2.3e-73 529507007831 flagellar protein FliS; Validated; Region: fliS; PRK05685 529507007832 HMMPfam hit to PF02561, Flagellar protein FliS, score 6.8e-38 529507007833 Flagellar protein FliT; Region: FliT; cl05125 529507007834 HMMPfam hit to PF05400, Flagellar protein FliT, score 6.9e-26 529507007835 PS00120 Lipases, serine active site. 529507007836 Signal peptide predicted for PMI1627 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21 529507007837 PS00017 ATP/GTP-binding site motif A (P-loop). 529507007838 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 529507007839 HMMPfam hit to PF02049, Flagellar hook-basal body complex protein Fl, score 4.5e-27 529507007840 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 529507007841 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 529507007842 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 529507007843 HMMPfam hit to PF01514, Secretory protein of YscJ/FliF family, score 3.3e-89 529507007844 1 probable transmembrane helix predicted for PMI1630 by TMHMM2.0 at aa 28-50 529507007845 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 529507007846 FliG C-terminal domain; Region: FliG_C; pfam01706 529507007847 HMMPfam hit to PF01706, FliG C-terminal domain, score 6.9e-57 529507007848 flagellar assembly protein H; Validated; Region: fliH; PRK05687 529507007849 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 529507007850 Flagellar assembly protein FliH; Region: FliH; pfam02108 529507007851 HMMPfam hit to PF02108, Flagellar assembly protein FliH, score 7.8e-40 529507007852 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 529507007853 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 529507007854 Walker A motif/ATP binding site; other site 529507007855 Walker B motif; other site 529507007856 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleotid, score 3.3e-110 529507007857 PS00017 ATP/GTP-binding site motif A (P-loop). 529507007858 PS00152 ATP synthase alpha and beta subunits signature. 529507007859 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 529507007860 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 529507007861 HMMPfam hit to PF02050, Flagellar FliJ protein, score 3e-38 529507007862 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 529507007863 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 529507007864 HMMPfam hit to PF02120, Flagellar hook-length control protein, score 1.9e-25 529507007865 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 529507007866 Signal peptide predicted for PMI1636 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.622 between residues 30 and 31 529507007867 HMMPfam hit to PF03748, Flagellar basal body-associated protein FliL, score 2.9e-25 529507007868 1 probable transmembrane helix predicted for PMI1636 by TMHMM2.0 at aa 13-35 529507007869 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 529507007870 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 529507007871 HMMPfam hit to PF02154, Flagellar motor switch protein FliM, score 7.1e-108 529507007872 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 529507007873 flagellar motor switch protein; Validated; Region: fliN; PRK05698 529507007874 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) prot, score 2.4e-34 529507007875 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 529507007876 1 probable transmembrane helix predicted for PMI1639 by TMHMM2.0 at aa 36-58 529507007877 HMMPfam hit to PF04347, Flagellar biosynthesis protein, FliO, score 2.3e-24 529507007878 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 529507007879 Signal peptide predicted for PMI1640 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.972 between residues 32 and 33 529507007880 5 probable transmembrane helices predicted for PMI1640 by TMHMM2.0 at aa 13-32, 56-78, 99-116, 196-218 and 225-247 529507007881 HMMPfam hit to PF00813, FliP family, score 3.5e-119 529507007882 PS01060 Flagella transport protein fliP family signature 1. 529507007883 PS01061 Flagella transport protein fliP family signature 2. 529507007884 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 529507007885 Signal peptide predicted for PMI1641 by SignalP 2.0 HMM (Signal peptide probability 0.876) with cleavage site probability 0.862 between residues 40 and 41 529507007886 HMMPfam hit to PF01313, Bacterial export proteins, family, score 1.5e-36 529507007887 2 probable transmembrane helices predicted for PMI1641 by TMHMM2.0 at aa 20-42 and 55-77 529507007888 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 529507007889 HMMPfam hit to PF01311, Bacterial export proteins, family, score 2.3e-76 529507007890 6 probable transmembrane helices predicted for PMI1642 by TMHMM2.0 at aa 15-34, 41-58, 68-87, 135-157, 177-199 and 211-233 529507007891 Signal peptide predicted for PMI1643 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.988 between residues 20 and 21 529507007892 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 529507007893 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 529507007894 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 3.3e-09 529507007895 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 529507007896 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 529507007897 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 529507007898 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 6.5e-14 529507007899 HMMPfam hit to PF00460, Flagella basal body rod protein, score 8.3e-06 529507007900 Signal peptide predicted for PMI1645 by SignalP 2.0 HMM (Signal peptide probability 0.923) with cleavage site probability 0.589 between residues 18 and 19 529507007901 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 529507007902 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 529507007903 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 529507007904 HMMPfam hit to PF01832, Mannosyl-glycoprotein endo-beta-N-ace, score 4.4e-43 529507007905 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 529507007906 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 529507007907 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 529507007908 HMMPfam hit to PF02119, Flagellar P-ring protein, score 3.2e-204 529507007909 Signal peptide predicted for PMI1647 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 22 and 23 529507007910 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 529507007911 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 529507007912 HMMPfam hit to PF02107, Flagellar L-ring protein, score 2.1e-85 529507007913 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507007914 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 529507007915 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 529507007916 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 529507007917 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 2e-21 529507007918 HMMPfam hit to PF00460, Flagella basal body rod protein, score 4.5e-15 529507007919 PS00588 Flagella basal body rod proteins signature. 529507007920 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 529507007921 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 529507007922 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 0.00056 529507007923 HMMPfam hit to PF00460, Flagella basal body rod protein, score 6.4e-10 529507007924 PS00588 Flagella basal body rod proteins signature. 529507007925 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 529507007926 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 529507007927 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 529507007928 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 529507007929 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 2.5e-18 529507007930 HMMPfam hit to PF07559, Flagellar basal body protein FlaE, score 3.2e-28 529507007931 HMMPfam hit to PF00460, Flagella basal body rod protein, score 3.3e-11 529507007932 PS00588 Flagella basal body rod proteins signature. 529507007933 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 529507007934 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 529507007935 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 529507007936 HMMPfam hit to PF03963, Flagellar hook capping protein, score 6.1e-20 529507007937 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 529507007938 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 529507007939 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 529507007940 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 3.5e-08 529507007941 HMMPfam hit to PF00460, Flagella basal body rod protein, score 4.5e-09 529507007942 PS00588 Flagella basal body rod proteins signature. 529507007943 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 529507007944 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 529507007945 HMMPfam hit to PF00460, Flagella basal body rod protein, score 6.9e-10 529507007946 PS00588 Flagella basal body rod proteins signature. 529507007947 SAF-like; Region: SAF_2; pfam13144 529507007948 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 529507007949 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 529507007950 Signal peptide predicted for PMI1655 by SignalP 2.0 HMM (Signal peptide probability 0.707) with cleavage site probability 0.673 between residues 21 and 22 529507007951 HMMPfam hit to PF03240, FlgA family, score 8.4e-77 529507007952 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 529507007953 HMMPfam hit to PF04316, Anti-sigma-28 factor, FlgM, score 8.7e-34 529507007954 FlgN protein; Region: FlgN; cl09176 529507007955 HMMPfam hit to PF05130, FlgN protein, score 1.8e-19 529507007956 haemagglutination activity domain; Region: Haemagg_act; pfam05860 529507007957 HMMPfam hit to PF05860, haemagglutination activity domain, score 8.2e-40 529507007958 1 probable transmembrane helix predicted for PMI1658 by TMHMM2.0 at aa 7-29 529507007959 Signal peptide predicted for PMI1658 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.975 between residues 24 and 25 529507007960 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507007961 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 529507007962 FHIPEP family; Region: FHIPEP; pfam00771 529507007963 HMMPfam hit to PF00771, FHIPEP family, score 0 529507007964 7 probable transmembrane helices predicted for PMI1659 by TMHMM2.0 at aa 21-38, 42-64, 76-98, 118-140, 209-231, 251-273 and 294-316 529507007965 PS00994 Bacterial export FHIPEP family signature. 529507007966 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 529507007967 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 529507007968 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 529507007969 HMMPfam hit to PF01312, FlhB HrpN YscU SpaS Family, score 5.4e-149 529507007970 4 probable transmembrane helices predicted for PMI1660 by TMHMM2.0 at aa 33-55, 90-112, 143-165 and 189-211 529507007971 chemotaxis regulator CheZ; Provisional; Region: PRK11166 529507007972 HMMPfam hit to PF04344, Chemotaxis phosphatase, CheZ, score 1.9e-102 529507007973 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 529507007974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507007975 active site 529507007976 phosphorylation site [posttranslational modification] 529507007977 intermolecular recognition site; other site 529507007978 dimerization interface [polypeptide binding]; other site 529507007979 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.4e-39 529507007980 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 529507007981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507007982 active site 529507007983 phosphorylation site [posttranslational modification] 529507007984 intermolecular recognition site; other site 529507007985 dimerization interface [polypeptide binding]; other site 529507007986 CheB methylesterase; Region: CheB_methylest; pfam01339 529507007987 HMMPfam hit to PF01339, CheB methylesterase, score 1.6e-115 529507007988 HMMPfam hit to PF00072, Response regulator receiver domain, score 5.7e-32 529507007989 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 529507007990 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 529507007991 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 529507007992 HMMPfam hit to PF01739, CheR methyltransferase, SAM binding domain, score 9.3e-80 529507007993 HMMPfam hit to PF03705, CheR methyltransferase, all-alpha domain, score 2.2e-12 529507007994 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 529507007995 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 529507007996 dimer interface [polypeptide binding]; other site 529507007997 ligand binding site [chemical binding]; other site 529507007998 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 529507007999 dimerization interface [polypeptide binding]; other site 529507008000 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 529507008001 dimer interface [polypeptide binding]; other site 529507008002 putative CheW interface [polypeptide binding]; other site 529507008003 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 4.8e-103 529507008004 PS00538 Bacterial chemotaxis sensory transducers signature. 529507008005 HMMPfam hit to PF00672, HAMP domain, score 1.1e-09 529507008006 2 probable transmembrane helices predicted for PMI1665 by TMHMM2.0 at aa 15-37 and 189-211 529507008007 HMMPfam hit to PF02203, Tar ligand binding domain homologue, score 5.6e-09 529507008008 Signal peptide predicted for PMI1665 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.468 between residues 27 and 28 529507008009 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 529507008010 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 529507008011 dimer interface [polypeptide binding]; other site 529507008012 ligand binding site [chemical binding]; other site 529507008013 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 529507008014 dimerization interface [polypeptide binding]; other site 529507008015 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 529507008016 dimer interface [polypeptide binding]; other site 529507008017 putative CheW interface [polypeptide binding]; other site 529507008018 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 9.4e-114 529507008019 PS00538 Bacterial chemotaxis sensory transducers signature. 529507008020 HMMPfam hit to PF00672, HAMP domain, score 3.2e-13 529507008021 2 probable transmembrane helices predicted for PMI1666 by TMHMM2.0 at aa 10-32 and 196-218 529507008022 HMMPfam hit to PF02203, Tar ligand binding domain homologue, score 4.9e-09 529507008023 Signal peptide predicted for PMI1666 by SignalP 2.0 HMM (Signal peptide probability 0.962) with cleavage site probability 0.298 between residues 33 and 34 529507008024 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 529507008025 putative CheA interaction surface; other site 529507008026 HMMPfam hit to PF01584, CheW-like domain, score 9.4e-32 529507008027 chemotaxis protein CheA; Provisional; Region: PRK10547 529507008028 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 529507008029 putative binding surface; other site 529507008030 active site 529507008031 CheY binding; Region: CheY-binding; pfam09078 529507008032 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 529507008033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 529507008034 ATP binding site [chemical binding]; other site 529507008035 Mg2+ binding site [ion binding]; other site 529507008036 G-X-G motif; other site 529507008037 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 529507008038 HMMPfam hit to PF01584, CheW-like domain, score 4.4e-28 529507008039 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 7.8e-26 529507008040 HMMPfam hit to PF02895, Signal transducing histidine kinase, hom, score 7.1e-25 529507008041 HMMPfam hit to PF01627, Hpt domain, score 8.4e-17 529507008042 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 529507008043 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 529507008044 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 529507008045 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 529507008046 ligand binding site [chemical binding]; other site 529507008047 HMMPfam hit to PF00691, OmpA family, score 1.4e-20 529507008048 Signal peptide predicted for PMI1669 by SignalP 2.0 HMM (Signal peptide probability 0.842) with cleavage site probability 0.800 between residues 49 and 50 529507008049 1 probable transmembrane helix predicted for PMI1669 by TMHMM2.0 at aa 23-45 529507008050 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 529507008051 flagellar motor protein MotA; Validated; Region: PRK09110 529507008052 4 probable transmembrane helices predicted for PMI1670 by TMHMM2.0 at aa 2-24, 34-56, 172-191 and 201-223 529507008053 PS01307 Flagellar motor protein motA family signature. 529507008054 transcriptional activator FlhC; Provisional; Region: PRK12722 529507008055 HMMPfam hit to PF05280, Flagellar transcriptional activator (FlhC), score 4.2e-163 529507008056 transcriptional activator FlhD; Provisional; Region: PRK02909 529507008057 HMMPfam hit to PF05247, Flagellar transcriptional activator (FlhD), score 3.6e-67 529507008058 magnesium transport protein MgtC; Provisional; Region: PRK15385 529507008059 MgtC family; Region: MgtC; pfam02308 529507008060 HMMPfam hit to PF02308, MgtC family, score 4.8e-73 529507008061 4 probable transmembrane helices predicted for PMI1674 by TMHMM2.0 at aa 10-27, 39-58, 68-85 and 98-120 529507008062 hypothetical protein; Provisional; Region: PRK10708 529507008063 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 529507008064 DNA-binding site [nucleotide binding]; DNA binding site 529507008065 RNA-binding motif; other site 529507008066 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 5.5e-44 529507008067 PS00352 'Cold-shock' DNA-binding domain signature. 529507008068 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 529507008069 2 probable transmembrane helices predicted for PMI1677 by TMHMM2.0 at aa 36-54 and 58-80 529507008070 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 529507008071 active site 529507008072 substrate binding pocket [chemical binding]; other site 529507008073 dimer interface [polypeptide binding]; other site 529507008074 HMMPfam hit to PF01979, Amidohydrolase family, score 2.1e-64 529507008075 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507008076 PS00483 Dihydroorotase signature 2. 529507008077 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 529507008078 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 529507008079 cheY-homologous receiver domain; Region: REC; smart00448 529507008080 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 529507008081 DNA binding residues [nucleotide binding] 529507008082 dimerization interface [polypeptide binding]; other site 529507008083 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR family, score 1.6e-08 529507008084 Predicted helix-turn-helix motif with score 1801.000, SD 5.32 at aa 152-173, sequence LPNYQIAKKLKISNSTVYSHKR 529507008085 tetrathionate reductase subunit A; Provisional; Region: PRK14991 529507008086 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 529507008087 putative [Fe4-S4] binding site [ion binding]; other site 529507008088 putative molybdopterin cofactor binding site [chemical binding]; other site 529507008089 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 529507008090 putative molybdopterin cofactor binding site; other site 529507008091 Predicted helix-turn-helix motif with score 1094.000, SD 2.91 at aa 473-494, sequence MSLAEYSERCKVPESTIIALAR 529507008092 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 dom, score 6.9e-05 529507008093 Signal peptide predicted for PMI1681 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.946 between residues 23 and 24 529507008094 tetrathionate reductase subunit C; Provisional; Region: PRK14992 529507008095 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 529507008096 9 probable transmembrane helices predicted for PMI1682 by TMHMM2.0 at aa 20-42, 54-76, 96-118, 130-149, 164-186, 198-220, 235-257, 264-286 and 306-328 529507008097 HMMPfam hit to PF03916, Polysulphide reductase, NrfD, score 1.2e-21 529507008098 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507008099 tetrathionate reductase subunit B; Provisional; Region: PRK14993 529507008100 4Fe-4S binding domain; Region: Fer4; pfam00037 529507008101 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 7.5e-08 529507008102 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507008103 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.0096 529507008104 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 529507008105 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 529507008106 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 529507008107 dimer interface [polypeptide binding]; other site 529507008108 phosphorylation site [posttranslational modification] 529507008109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 529507008110 ATP binding site [chemical binding]; other site 529507008111 Mg2+ binding site [ion binding]; other site 529507008112 G-X-G motif; other site 529507008113 Signal peptide predicted for PMI1684 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 30 and 31 529507008114 2 probable transmembrane helices predicted for PMI1684 by TMHMM2.0 at aa 12-30 and 311-333 529507008115 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 5.8e-06 529507008116 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.3e-20 529507008117 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 529507008118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507008119 active site 529507008120 phosphorylation site [posttranslational modification] 529507008121 intermolecular recognition site; other site 529507008122 dimerization interface [polypeptide binding]; other site 529507008123 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 529507008124 DNA binding residues [nucleotide binding] 529507008125 dimerization interface [polypeptide binding]; other site 529507008126 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.3e-24 529507008127 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 7e-17 529507008128 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 529507008129 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 529507008130 putative acyl-acceptor binding pocket; other site 529507008131 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltr, score 1.8e-130 529507008132 1 probable transmembrane helix predicted for PMI1686 by TMHMM2.0 at aa 20-42 529507008133 drug efflux system protein MdtG; Provisional; Region: PRK09874 529507008134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507008135 putative substrate translocation pore; other site 529507008136 Signal peptide predicted for PMI1687 by SignalP 2.0 HMM (Signal peptide probability 0.856) with cleavage site probability 0.793 between residues 39 and 40 529507008137 HMMPfam hit to PF00083, Sugar (and other) transporter, score 0.00014 529507008138 10 probable transmembrane helices predicted for PMI1687 by TMHMM2.0 at aa 13-35, 50-72, 84-106, 140-162, 169-191, 222-244, 251-273, 288-310, 317-339 and 372-394 529507008139 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.6e-51 529507008140 POT family; Region: PTR2; cl17359 529507008141 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 7.9e-16 529507008142 14 probable transmembrane helices predicted for PMI1688 by TMHMM2.0 at aa 31-49, 59-81, 90-112, 117-139, 152-174, 179-201, 233-255, 259-281, 293-310, 336-358, 374-391, 406-428, 441-463 and 478-500 529507008143 PS01022 PTR2 family proton/oligopeptide symporters signature 1. 529507008144 HMMPfam hit to PF00854, POT family, score 1.5e-44 529507008145 PS01023 PTR2 family proton/oligopeptide symporters signature 2. 529507008146 2 probable transmembrane helices predicted for PMI1689 by TMHMM2.0 at aa 30-52 and 57-76 529507008147 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 529507008148 HMMPfam hit to PF02567, Phenazine biosynthesis-like protein, score 3.2e-50 529507008149 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 529507008150 HMMPfam hit to PF03061, Thioesterase superfamily, score 8.6e-13 529507008151 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 529507008152 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 529507008153 trimer interface [polypeptide binding]; other site 529507008154 active site 529507008155 substrate binding site [chemical binding]; other site 529507008156 CoA binding site [chemical binding]; other site 529507008157 PS00101 Hexapeptide-repeat containing-transferases signature. 529507008158 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.00018 529507008159 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 35 529507008160 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 529507008161 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 529507008162 active site 529507008163 FMN binding site [chemical binding]; other site 529507008164 substrate binding site [chemical binding]; other site 529507008165 homotetramer interface [polypeptide binding]; other site 529507008166 catalytic residue [active] 529507008167 HMMPfam hit to PF00724, NADH:flavin oxidoreductase / NADH oxidas, score 2e-80 529507008168 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 529507008169 3 probable transmembrane helices predicted for PMI1695 by TMHMM2.0 at aa 5-27, 42-64 and 77-99 529507008170 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 529507008171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507008172 active site 529507008173 phosphorylation site [posttranslational modification] 529507008174 intermolecular recognition site; other site 529507008175 dimerization interface [polypeptide binding]; other site 529507008176 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 529507008177 DNA binding site [nucleotide binding] 529507008178 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.3e-23 529507008179 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 2.2e-19 529507008180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 529507008181 dimer interface [polypeptide binding]; other site 529507008182 phosphorylation site [posttranslational modification] 529507008183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 529507008184 ATP binding site [chemical binding]; other site 529507008185 Mg2+ binding site [ion binding]; other site 529507008186 G-X-G motif; other site 529507008187 2 probable transmembrane helices predicted for PMI1697 by TMHMM2.0 at aa 7-29 and 168-190 529507008188 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 6.2e-12 529507008189 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 5.8e-29 529507008190 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 529507008191 4 probable transmembrane helices predicted for PMI1698 by TMHMM2.0 at aa 6-28, 41-60, 65-82 and 87-106 529507008192 Signal peptide predicted for PMI1698 by SignalP 2.0 HMM (Signal peptide probability 0.951) with cleavage site probability 0.527 between residues 20 and 21 529507008193 AzlC protein; Region: AzlC; cl00570 529507008194 5 probable transmembrane helices predicted for PMI1699 by TMHMM2.0 at aa 16-38, 58-80, 126-148, 158-177 and 186-208 529507008195 HMMPfam hit to PF03591, AzlC protein, score 5.4e-13 529507008196 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 529507008197 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507008198 non-specific DNA binding site [nucleotide binding]; other site 529507008199 salt bridge; other site 529507008200 sequence-specific DNA binding site [nucleotide binding]; other site 529507008201 Cupin domain; Region: Cupin_2; cl17218 529507008202 HMMPfam hit to PF01381, Helix-turn-helix, score 7.6e-17 529507008203 Predicted helix-turn-helix motif with score 2052.000, SD 6.18 at aa 24-45, sequence LSLAEIARRAGIAKSTLSQLEA 529507008204 HMMPfam hit to PF07883, Cupin domain, score 0.001 529507008205 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 529507008206 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 529507008207 homodimer interface [polypeptide binding]; other site 529507008208 substrate-cofactor binding pocket; other site 529507008209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507008210 catalytic residue [active] 529507008211 HMMPfam hit to PF01063, Aminotransferase class IV, score 4.4e-74 529507008212 PS00770 Aminotransferases class-IV signature. 529507008213 acid-resistance membrane protein; Provisional; Region: PRK10209 529507008214 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 529507008215 Signal peptide predicted for PMI1702 by SignalP 2.0 HMM (Signal peptide probability 0.843) with cleavage site probability 0.300 between residues 61 and 62 529507008216 6 probable transmembrane helices predicted for PMI1702 by TMHMM2.0 at aa 21-43, 47-69, 76-98, 104-126, 133-155 and 165-187 529507008217 PS00211 ABC transporters family signature. 529507008218 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 529507008219 Mechanosensitive ion channel; Region: MS_channel; pfam00924 529507008220 5 probable transmembrane helices predicted for PMI1704 by TMHMM2.0 at aa 21-40, 68-90, 103-125, 138-160 and 165-182 529507008221 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 1.2e-41 529507008222 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 529507008223 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 529507008224 putative [Fe4-S4] binding site [ion binding]; other site 529507008225 putative molybdopterin cofactor binding site [chemical binding]; other site 529507008226 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 529507008227 putative molybdopterin cofactor binding site; other site 529507008228 Signal peptide predicted for PMI1705 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.988 between residues 45 and 46 529507008229 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 do, score 8.8e-06 529507008230 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 529507008231 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 5.5e-108 529507008232 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 1.5e-29 529507008233 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 529507008234 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 529507008235 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507008236 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 1.7e-06 529507008237 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507008238 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 529507008239 8 probable transmembrane helices predicted for PMI1707 by TMHMM2.0 at aa 4-26, 39-61, 81-100, 109-131, 141-160, 167-186, 201-223 and 230-251 529507008240 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 529507008241 HMMPfam hit to PF06041, Bacterial protein of unknown function (DUF92, score 2.2e-76 529507008242 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 529507008243 2 probable transmembrane helices predicted for PMI1709 by TMHMM2.0 at aa 4-26 and 35-57 529507008244 prophage 529507008245 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 529507008246 Baseplate J-like protein; Region: Baseplate_J; cl01294 529507008247 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 529507008248 Phage Connector (GP10); Region: Phage_connector; cl11526 529507008249 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 529507008250 Signal peptide predicted for PMI1714 by SignalP 2.0 HMM (Signal peptide probability 0.700) with cleavage site probability 0.300 between residues 23 and 24 529507008251 PS00559 Eukaryotic molybdopterin oxidoreductases signature. 529507008252 PS00678 Trp-Asp (WD) repeats signature. 529507008253 2 probable transmembrane helices predicted for PMI1718 by TMHMM2.0 at aa 460-479 and 486-508 529507008254 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 529507008255 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 529507008256 HMMPfam hit to PF03245, Bacteriophage lysis protein, score 9e-11 529507008257 1 probable transmembrane helix predicted for PMI1723 by TMHMM2.0 at aa 4-23 529507008258 virion protein; Provisional; Region: V; PHA02564 529507008259 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 529507008260 HMMPfam hit to PF05106, Phage holin family (Lysis protein S), score 1.2e-29 529507008261 2 probable transmembrane helices predicted for PMI1725 by TMHMM2.0 at aa 21-43 and 63-85 529507008262 Antitermination protein; Region: Antiterm; pfam03589 529507008263 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 529507008264 HMMPfam hit to PF03589, Antitermination protein, score 2.4e-07 529507008265 Predicted transcriptional regulator [Transcription]; Region: COG2932 529507008266 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507008267 non-specific DNA binding site [nucleotide binding]; other site 529507008268 salt bridge; other site 529507008269 sequence-specific DNA binding site [nucleotide binding]; other site 529507008270 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 529507008271 Catalytic site [active] 529507008272 HMMPfam hit to PF00717, Peptidase S24-like, score 1.3e-07 529507008273 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 529507008274 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 529507008275 active site 529507008276 HIGH motif; other site 529507008277 dimer interface [polypeptide binding]; other site 529507008278 KMSKS motif; other site 529507008279 HMMPfam hit to PF00579, tRNA synthetases class I (W and Y), score 3.1e-73 529507008280 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 529507008281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 529507008282 ATP binding site [chemical binding]; other site 529507008283 Mg2+ binding site [ion binding]; other site 529507008284 G-X-G motif; other site 529507008285 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 529507008286 putative binding surface; other site 529507008287 active site 529507008288 Signal peptide predicted for PMI1729 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.872 between residues 31 and 32 529507008289 2 probable transmembrane helices predicted for PMI1729 by TMHMM2.0 at aa 15-34 and 298-320 529507008290 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 5.2e-14 529507008291 HMMPfam hit to PF01627, Hpt domain, score 1.9e-13 529507008292 transcriptional regulator RcsB; Provisional; Region: PRK10840 529507008293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507008294 active site 529507008295 phosphorylation site [posttranslational modification] 529507008296 intermolecular recognition site; other site 529507008297 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 529507008298 DNA binding residues [nucleotide binding] 529507008299 dimerization interface [polypeptide binding]; other site 529507008300 HMMPfam hit to PF00072, Response regulator receiver domain, score 9.9e-31 529507008301 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 4.2e-21 529507008302 PS00622 Bacterial regulatory proteins, luxR family signature. 529507008303 Predicted helix-turn-helix motif with score 1130.000, SD 3.04 at aa 166-187, sequence FLVTEIAKKLNRSIKTISSQKK 529507008304 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 529507008305 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 529507008306 dimer interface [polypeptide binding]; other site 529507008307 phosphorylation site [posttranslational modification] 529507008308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 529507008309 ATP binding site [chemical binding]; other site 529507008310 Mg2+ binding site [ion binding]; other site 529507008311 G-X-G motif; other site 529507008312 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 529507008313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507008314 active site 529507008315 phosphorylation site [posttranslational modification] 529507008316 intermolecular recognition site; other site 529507008317 dimerization interface [polypeptide binding]; other site 529507008318 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.5e-36 529507008319 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 1.6e-41 529507008320 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 8.5e-24 529507008321 2 probable transmembrane helices predicted for PMI1731 by TMHMM2.0 at aa 20-42 and 314-336 529507008322 Signal peptide predicted for PMI1731 by SignalP 2.0 HMM (Signal peptide probability 0.920) with cleavage site probability 0.357 between residues 29 and 30 529507008323 DNA gyrase subunit A; Validated; Region: PRK05560 529507008324 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 529507008325 CAP-like domain; other site 529507008326 active site 529507008327 primary dimer interface [polypeptide binding]; other site 529507008328 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 529507008329 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 529507008330 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 529507008331 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 529507008332 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 529507008333 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 529507008334 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 2.4e-15 529507008335 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 1.2e-15 529507008336 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 1.8e-13 529507008337 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 8e-12 529507008338 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 6.1e-16 529507008339 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 2.1e-12 529507008340 HMMPfam hit to PF00521, DNA gyrase/topoisomerase IV, subunit A, score 0 529507008341 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 529507008342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507008343 S-adenosylmethionine binding site [chemical binding]; other site 529507008344 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 529507008345 ATP cone domain; Region: ATP-cone; pfam03477 529507008346 Class I ribonucleotide reductase; Region: RNR_I; cd01679 529507008347 active site 529507008348 dimer interface [polypeptide binding]; other site 529507008349 catalytic residues [active] 529507008350 effector binding site; other site 529507008351 R2 peptide binding site; other site 529507008352 HMMPfam hit to PF03477, ATP cone domain, score 2.8e-21 529507008353 HMMPfam hit to PF00317, Ribonucleotide reductase, all-alpha d, score 4.3e-23 529507008354 HMMPfam hit to PF02867, Ribonucleotide reductase, barrel doma, score 2e-257 529507008355 PS00089 Ribonucleotide reductase large subunit signature. 529507008356 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 529507008357 dimer interface [polypeptide binding]; other site 529507008358 putative radical transfer pathway; other site 529507008359 diiron center [ion binding]; other site 529507008360 tyrosyl radical; other site 529507008361 HMMPfam hit to PF00268, Ribonucleotide reductase, small chain, score 7.6e-156 529507008362 PS00368 Ribonucleotide reductase small subunit signature. 529507008363 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 529507008364 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 529507008365 catalytic loop [active] 529507008366 iron binding site [ion binding]; other site 529507008367 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 1.5e-09 529507008368 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 529507008369 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 529507008370 Signal peptide predicted for PMI1737 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.484 between residues 27 and 28 529507008371 HMMPfam hit to PF06004, Bacterial protein of unknown function (DUF90, score 1.5e-23 529507008372 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507008373 tyrosine transporter TyrP; Provisional; Region: PRK15132 529507008374 aromatic amino acid transport protein; Region: araaP; TIGR00837 529507008375 Signal peptide predicted for PMI1738 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.453 between residues 28 and 29 529507008376 HMMPfam hit to PF03222, Tryptophan/tyrosine permease family, score 1.3e-161 529507008377 11 probable transmembrane helices predicted for PMI1738 by TMHMM2.0 at aa 7-29, 33-55, 76-98, 118-137, 144-166, 181-203, 216-238, 273-295, 308-330, 334-356 and 377-399 529507008378 YfaZ precursor; Region: YfaZ; pfam07437 529507008379 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 529507008380 HMMPfam hit to PF07437, YfaZ precursor, score 6.4e-63 529507008381 Signal peptide predicted for PMI1739 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.903 between residues 21 and 22 529507008382 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 529507008383 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 529507008384 tetramer interface [polypeptide binding]; other site 529507008385 heme binding pocket [chemical binding]; other site 529507008386 NADPH binding site [chemical binding]; other site 529507008387 HMMPfam hit to PF00199, Catalase, score 2.9e-296 529507008388 PS00438 Catalase proximal active site signature. 529507008389 PS00437 Catalase proximal heme-ligand signature. 529507008390 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 529507008391 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 529507008392 acyl-activating enzyme (AAE) consensus motif; other site 529507008393 putative AMP binding site [chemical binding]; other site 529507008394 putative active site [active] 529507008395 putative CoA binding site [chemical binding]; other site 529507008396 HMMPfam hit to PF00501, AMP-binding enzyme, score 1.7e-59 529507008397 PS00455 AMP-binding domain signature. 529507008398 O-succinylbenzoate synthase; Provisional; Region: PRK05105 529507008399 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 529507008400 active site 529507008401 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 529507008402 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 529507008403 substrate binding site [chemical binding]; other site 529507008404 oxyanion hole (OAH) forming residues; other site 529507008405 trimer interface [polypeptide binding]; other site 529507008406 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 7.7e-74 529507008407 PS00166 Enoyl-CoA hydratase/isomerase signature. 529507008408 PS00018 EF-hand calcium-binding domain. 529507008409 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 529507008410 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 0.0015 529507008411 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 529507008412 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 529507008413 dimer interface [polypeptide binding]; other site 529507008414 tetramer interface [polypeptide binding]; other site 529507008415 PYR/PP interface [polypeptide binding]; other site 529507008416 TPP binding site [chemical binding]; other site 529507008417 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 529507008418 TPP-binding site; other site 529507008419 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 529507008420 chorismate binding enzyme; Region: Chorismate_bind; cl10555 529507008421 HMMPfam hit to PF00425, chorismate binding enzyme, score 3.7e-72 529507008422 1 probable transmembrane helix predicted for PMI1747 by TMHMM2.0 at aa 257-279 529507008423 transposase (fragment) 529507008424 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 529507008425 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 529507008426 14 probable transmembrane helices predicted for PMI1750 by TMHMM2.0 at aa 10-29, 36-58, 73-95, 104-121, 125-147, 159-181, 201-223, 236-258, 268-290, 297-319, 329-351, 372-394, 409-431 and 452-471 529507008427 HMMPfam hit to PF00361, NADH-Ubiquinone/plastoquinone (complex I), score 1.8e-74 529507008428 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 529507008429 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 529507008430 12 probable transmembrane helices predicted for PMI1751 by TMHMM2.0 at aa 4-18, 30-49, 85-107, 120-142, 174-196, 216-235, 286-308, 317-339, 343-365, 385-407, 422-439 and 459-481 529507008431 HMMPfam hit to PF00361, NADH-Ubiquinone/plastoquinone (complex I), score 3.2e-74 529507008432 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 529507008433 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 529507008434 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 529507008435 17 probable transmembrane helices predicted for PMI1752 by TMHMM2.0 at aa 4-21, 28-50, 77-99, 112-131, 136-158, 171-193, 208-227, 248-267, 282-300, 307-328, 332-354, 375-397, 412-434, 455-475, 490-512, 532-549 and 588-610 529507008436 HMMPfam hit to PF00361, NADH-Ubiquinone/plastoquinone (complex, score 3e-112 529507008437 HMMPfam hit to PF00662, NADH-Ubiquinone oxidoreductase (complex, score 1.2e-25 529507008438 Signal peptide predicted for PMI1752 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.958 between residues 26 and 27 529507008439 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 529507008440 HMMPfam hit to PF00420, NADH-ubiquinone/plastoquinone oxidoreduct, score 1.9e-30 529507008441 3 probable transmembrane helices predicted for PMI1753 by TMHMM2.0 at aa 4-23, 28-50 and 60-82 529507008442 Signal peptide predicted for PMI1753 by SignalP 2.0 HMM (Signal peptide probability 0.650) with cleavage site probability 0.275 between residues 25 and 26 529507008443 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 529507008444 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 529507008445 HMMPfam hit to PF00499, NADH-ubiquinone/plastoquinone oxidoreduct, score 7.8e-11 529507008446 5 probable transmembrane helices predicted for PMI1754 by TMHMM2.0 at aa 4-21, 28-50, 55-77, 90-112 and 132-154 529507008447 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 529507008448 4Fe-4S binding domain; Region: Fer4; pfam00037 529507008449 4Fe-4S binding domain; Region: Fer4; pfam00037 529507008450 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 9.4e-08 529507008451 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507008452 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 8.6e-05 529507008453 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507008454 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 529507008455 8 probable transmembrane helices predicted for PMI1756 by TMHMM2.0 at aa 10-32, 81-103, 113-135, 155-174, 184-206, 236-258, 268-290 and 299-321 529507008456 HMMPfam hit to PF00146, NADH dehydrogenase, score 3.5e-169 529507008457 PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. 529507008458 PS00667 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. 529507008459 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 529507008460 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 529507008461 catalytic loop [active] 529507008462 iron binding site [ion binding]; other site 529507008463 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 529507008464 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 529507008465 [4Fe-4S] binding site [ion binding]; other site 529507008466 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 529507008467 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 1.3e-06 529507008468 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 dom, score 1.3e-16 529507008469 PS00643 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. 529507008470 PS00642 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. 529507008471 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding dom, score 3e-13 529507008472 PS00641 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. 529507008473 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507008474 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 529507008475 SLBB domain; Region: SLBB; pfam10531 529507008476 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 529507008477 PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. 529507008478 HMMPfam hit to PF01512, Respiratory-chain NADH dehydrogenase, score 9.7e-168 529507008479 PS00644 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. 529507008480 NADH dehydrogenase subunit E; Validated; Region: PRK07539 529507008481 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 529507008482 putative dimer interface [polypeptide binding]; other site 529507008483 [2Fe-2S] cluster binding site [ion binding]; other site 529507008484 HMMPfam hit to PF01257, Respiratory-chain NADH dehydrogenase, score 3e-85 529507008485 PS01099 Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. 529507008486 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 529507008487 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 529507008488 NADH dehydrogenase subunit D; Validated; Region: PRK06075 529507008489 HMMPfam hit to PF00346, Respiratory-chain NADH dehydrogenase,, score 6.7e-176 529507008490 PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. 529507008491 HMMPfam hit to PF00329, Respiratory-chain NADH dehydrogenase,, score 5.7e-40 529507008492 PS00542 Respiratory chain NADH dehydrogenase 30 Kd subunit signature. 529507008493 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 529507008494 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 Kd sub, score 8.1e-56 529507008495 PS01150 Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. 529507008496 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 529507008497 HMMPfam hit to PF00507, NADH-ubiquinone/plastoquinone oxidoreduct, score 5e-40 529507008498 3 probable transmembrane helices predicted for PMI1762 by TMHMM2.0 at aa 10-32, 68-90 and 100-122 529507008499 PS00012 Phosphopantetheine attachment site. 529507008500 Signal peptide predicted for PMI1762 by SignalP 2.0 HMM (Signal peptide probability 0.621) with cleavage site probability 0.484 between residues 33 and 34 529507008501 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 529507008502 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507008503 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 529507008504 putative dimerization interface [polypeptide binding]; other site 529507008505 HMMPfam hit to PF03466, LysR substrate binding domain, score 3.2e-24 529507008506 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 529507008507 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.9e-16 529507008508 PS00044 Bacterial regulatory proteins, lysR family signature. 529507008509 Predicted helix-turn-helix motif with score 1312.000, SD 3.66 at aa 26-47, sequence NTFAAAAAAVCRTQSAVSQQMQ 529507008510 aminotransferase AlaT; Validated; Region: PRK09265 529507008511 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 529507008512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507008513 homodimer interface [polypeptide binding]; other site 529507008514 catalytic residue [active] 529507008515 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1.1e-33 529507008516 5'-nucleotidase; Provisional; Region: PRK03826 529507008517 HMMPfam hit to PF01966, HD domain, score 3.3e-10 529507008518 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 529507008519 transmembrane helices; other site 529507008520 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 529507008521 TrkA-C domain; Region: TrkA_C; pfam02080 529507008522 TrkA-C domain; Region: TrkA_C; pfam02080 529507008523 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 529507008524 11 probable transmembrane helices predicted for PMI1767 by TMHMM2.0 at aa 5-27, 34-53, 63-82, 103-125, 145-167, 179-201, 434-456, 469-488, 508-530, 549-571 and 591-613 529507008525 HMMPfam hit to PF02080, TrkA-C domain, score 3.6e-11 529507008526 HMMPfam hit to PF02080, TrkA-C domain, score 4.7e-13 529507008527 putative phosphatase; Provisional; Region: PRK11587 529507008528 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 529507008529 motif II; other site 529507008530 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1e-29 529507008531 hypothetical protein; Validated; Region: PRK05445 529507008532 HMMPfam hit to PF03887, YfbU domain, score 1.4e-94 529507008533 hypothetical protein; Provisional; Region: PRK01816 529507008534 HMMPfam hit to PF04217, Protein of unknown function, DUF412, score 2e-80 529507008535 2 probable transmembrane helices predicted for PMI1770 by TMHMM2.0 at aa 46-65 and 69-91 529507008536 propionate/acetate kinase; Provisional; Region: PRK12379 529507008537 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 529507008538 Signal peptide predicted for PMI1771 by SignalP 2.0 HMM (Signal peptide probability 0.658) with cleavage site probability 0.605 between residues 19 and 20 529507008539 HMMPfam hit to PF00871, Acetokinase family, score 3.6e-245 529507008540 PS01075 Acetate and butyrate kinases family signature 1. 529507008541 PS01076 Acetate and butyrate kinases family signature 2. 529507008542 phosphate acetyltransferase; Reviewed; Region: PRK05632 529507008543 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 529507008544 DRTGG domain; Region: DRTGG; pfam07085 529507008545 phosphate acetyltransferase; Region: pta; TIGR00651 529507008546 HMMPfam hit to PF07085, DRTGG domain, score 2.4e-56 529507008547 HMMPfam hit to PF01515, Phosphate acetyl/butaryl transferase, score 4.4e-188 529507008548 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 529507008549 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 529507008550 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 529507008551 Trp docking motif [polypeptide binding]; other site 529507008552 putative active site [active] 529507008553 Signal peptide predicted for PMI1773 by SignalP 2.0 HMM (Signal peptide probability 0.952) with cleavage site probability 0.659 between residues 33 and 34 529507008554 5 probable transmembrane helices predicted for PMI1773 by TMHMM2.0 at aa 7-29, 34-53, 60-76, 91-109 and 116-135 529507008555 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507008556 PS00364 Bacterial quinoprotein dehydrogenases signature 2. 529507008557 HMMPfam hit to PF01011, PQQ enzyme repeat, score 3.7e-09 529507008558 alanine racemase; Reviewed; Region: PRK13340 529507008559 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme, Alanine Racemase 2; Region: PLPDE_III_AR2; cd06826 529507008560 active site 529507008561 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 529507008562 dimer interface [polypeptide binding]; other site 529507008563 substrate binding site [chemical binding]; other site 529507008564 catalytic residues [active] 529507008565 HMMPfam hit to PF00842, Alanine racemase, C-terminal domain, score 1.1e-35 529507008566 HMMPfam hit to PF01168, Alanine racemase, N-terminal domain, score 5.8e-37 529507008567 Signal peptide predicted for PMI1774 by SignalP 2.0 HMM (Signal peptide probability 0.738) with cleavage site probability 0.502 between residues 35 and 36 529507008568 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507008569 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 529507008570 12 probable transmembrane helices predicted for PMI1775 by TMHMM2.0 at aa 7-29, 44-63, 98-117, 121-143, 148-170, 180-202, 223-245, 255-274, 314-336, 340-362, 369-391 and 395-417 529507008571 HMMPfam hit to PF04215, sugar-specific permease, SgaT/UlaA, score 9.6e-121 529507008572 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 529507008573 active site 529507008574 P-loop; other site 529507008575 phosphorylation site [posttranslational modification] 529507008576 HMMPfam hit to PF02302, PTS system, Lactose/Cellobiose specific IIB, score 2.6e-28 529507008577 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 529507008578 active site 529507008579 phosphorylation site [posttranslational modification] 529507008580 HMMPfam hit to PF00359, Phosphoenolpyruvate-dependent sugar phosph, score 9.2e-50 529507008581 PS00372 PTS EIIA domains phosphorylation site signature 2. 529507008582 Transcriptional regulators [Transcription]; Region: PurR; COG1609 529507008583 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 529507008584 DNA binding site [nucleotide binding] 529507008585 domain linker motif; other site 529507008586 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 529507008587 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 5.6e-07 529507008588 Predicted helix-turn-helix motif with score 1930.000, SD 5.76 at aa 13-34, sequence VTLQEVAKHAGVGSMTVSRALR 529507008589 PS00356 Bacterial regulatory proteins, lacI family signature. 529507008590 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 0.00013 529507008591 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 529507008592 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 529507008593 nudix motif; other site 529507008594 HMMPfam hit to PF00293, NUDIX domain, score 4.8e-23 529507008595 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 529507008596 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 529507008597 C-terminal domain interface [polypeptide binding]; other site 529507008598 GSH binding site (G-site) [chemical binding]; other site 529507008599 dimer interface [polypeptide binding]; other site 529507008600 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 529507008601 N-terminal domain interface [polypeptide binding]; other site 529507008602 putative dimer interface [polypeptide binding]; other site 529507008603 active site 529507008604 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 9.8e-09 529507008605 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal domain, score 4.3e-10 529507008606 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 529507008607 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 529507008608 putative NAD(P) binding site [chemical binding]; other site 529507008609 putative active site [active] 529507008610 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 529507008611 Flavoprotein; Region: Flavoprotein; pfam02441 529507008612 HMMPfam hit to PF02441, Flavoprotein, score 1.1e-44 529507008613 amidophosphoribosyltransferase; Provisional; Region: PRK09246 529507008614 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 529507008615 active site 529507008616 tetramer interface [polypeptide binding]; other site 529507008617 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 529507008618 active site 529507008619 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 2.1e-11 529507008620 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 529507008621 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 9.8e-57 529507008622 PS00443 Glutamine amidotransferases class-II active site. 529507008623 colicin V production protein; Provisional; Region: PRK10845 529507008624 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 529507008625 HMMPfam hit to PF02674, Colicin V production protein, score 2.9e-59 529507008626 4 probable transmembrane helices predicted for PMI1784 by TMHMM2.0 at aa 4-21, 28-50, 65-87 and 100-122 529507008627 cell division protein DedD; Provisional; Region: PRK11633 529507008628 Sporulation related domain; Region: SPOR; pfam05036 529507008629 HMMPfam hit to PF05036, Sporulation related repeat, score 0.14 529507008630 HMMPfam hit to PF05036, Sporulation related repeat, score 0.0023 529507008631 1 probable transmembrane helix predicted for PMI1785 by TMHMM2.0 at aa 7-29 529507008632 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 529507008633 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 529507008634 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 529507008635 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 0.0051 529507008636 PS01012 Folylpolyglutamate synthase signature 2. 529507008637 PS01011 Folylpolyglutamate synthase signature 1. 529507008638 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 529507008639 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 529507008640 hypothetical protein; Provisional; Region: PRK10847 529507008641 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 529507008642 4 probable transmembrane helices predicted for PMI1788 by TMHMM2.0 at aa 36-58, 78-100, 163-185 and 195-217 529507008643 HMMPfam hit to PF00597, DedA family, score 1.2e-60 529507008644 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 529507008645 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 529507008646 dimerization interface 3.5A [polypeptide binding]; other site 529507008647 active site 529507008648 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 3e-27 529507008649 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 6.6e-38 529507008650 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 529507008651 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 529507008652 HMMPfam hit to PF02774, Semialdehyde dehydrogenase, dimerisat, score 7.7e-34 529507008653 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD bindi, score 9.8e-27 529507008654 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 529507008655 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 529507008656 ligand binding site [chemical binding]; other site 529507008657 NAD binding site [chemical binding]; other site 529507008658 catalytic site [active] 529507008659 homodimer interface [polypeptide binding]; other site 529507008660 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 8.7e-51 529507008661 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 529507008662 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 529507008663 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrog, score 4e-18 529507008664 Cupin domain; Region: Cupin_2; pfam07883 529507008665 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 529507008666 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 529507008667 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.3e-08 529507008668 PS00041 Bacterial regulatory proteins, araC family signature. 529507008669 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.037 529507008670 Predicted helix-turn-helix motif with score 1169.000, SD 3.17 at aa 175-196, sequence TSLELWAKKRYTSERTLSRRCQ 529507008671 HMMPfam hit to PF07883, Cupin domain, score 0.0013 529507008672 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 529507008673 EamA-like transporter family; Region: EamA; pfam00892 529507008674 EamA-like transporter family; Region: EamA; pfam00892 529507008675 Signal peptide predicted for PMI1794 by SignalP 2.0 HMM (Signal peptide probability 0.950) with cleavage site probability 0.424 between residues 22 and 23 529507008676 10 probable transmembrane helices predicted for PMI1794 by TMHMM2.0 at aa 3-20, 35-54, 67-86, 91-113, 115-137, 152-169, 182-201, 211-233, 242-261 and 265-282 529507008677 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.3e-24 529507008678 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.8e-18 529507008679 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 529507008680 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 529507008681 dimer interface [polypeptide binding]; other site 529507008682 active site 529507008683 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 4.6e-61 529507008684 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 529507008685 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 3.8e-58 529507008686 PS00606 Beta-ketoacyl synthases active site. 529507008687 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 529507008688 Uncharacterized conserved protein [Function unknown]; Region: COG4121 529507008689 hydroxyglutarate oxidase; Provisional; Region: PRK11728 529507008690 HMMPfam hit to PF05430, Protein of unknown function (DUF752), score 5.6e-130 529507008691 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 4.4e-49 529507008692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 529507008693 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 529507008694 Coenzyme A binding pocket [chemical binding]; other site 529507008695 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 5.7e-16 529507008696 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507008697 Signal peptide predicted for PMI1798 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.944 between residues 19 and 20 529507008698 YfcL protein; Region: YfcL; pfam08891 529507008699 Protein of unknown function, DUF462; Region: DUF462; pfam04315 529507008700 HMMPfam hit to PF04315, Protein of unknown function, DUF462, score 1.3e-114 529507008701 hypothetical protein; Provisional; Region: PRK10621 529507008702 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 529507008703 7 probable transmembrane helices predicted for PMI1801 by TMHMM2.0 at aa 10-32, 80-99, 109-127, 134-153, 157-174, 195-217 and 232-249 529507008704 HMMPfam hit to PF01925, Domain of unknown function DUF81, score 5.4e-47 529507008705 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 529507008706 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 529507008707 Tetramer interface [polypeptide binding]; other site 529507008708 active site 529507008709 FMN-binding site [chemical binding]; other site 529507008710 HMMPfam hit to PF01264, Chorismate synthase, score 1.2e-227 529507008711 PS00789 Chorismate synthase signature 3. 529507008712 PS00788 Chorismate synthase signature 2. 529507008713 PS00787 Chorismate synthase signature 1. 529507008714 HemK family putative methylases; Region: hemK_fam; TIGR00536 529507008715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507008716 S-adenosylmethionine binding site [chemical binding]; other site 529507008717 PS00092 N-6 Adenine-specific DNA methylases signature. 529507008718 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 529507008719 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 529507008720 dimerization interface [polypeptide binding]; other site 529507008721 DPS ferroxidase diiron center [ion binding]; other site 529507008722 ion pore; other site 529507008723 HMMPfam hit to PF00210, Ferritin-like domain, score 1.2e-22 529507008724 hypothetical protein; Provisional; Region: PRK04946 529507008725 Smr domain; Region: Smr; pfam01713 529507008726 HMMPfam hit to PF01713, Smr domain, score 2e-28 529507008727 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 529507008728 catalytic core [active] 529507008729 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 529507008730 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 529507008731 substrate binding site [chemical binding]; other site 529507008732 oxyanion hole (OAH) forming residues; other site 529507008733 trimer interface [polypeptide binding]; other site 529507008734 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 529507008735 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 529507008736 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 3e-35 529507008737 PS00067 3-hydroxyacyl-CoA dehydrogenase signature. 529507008738 HMMPfam hit to PF02737, 3-hydroxyacyl-CoA dehydrogenase, NAD binding, score 9.9e-69 529507008739 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 7.8e-69 529507008740 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 529507008741 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 529507008742 dimer interface [polypeptide binding]; other site 529507008743 active site 529507008744 HMMPfam hit to PF02803, Thiolase, C-terminal domain, score 1.8e-51 529507008745 PS00099 Thiolases active site. 529507008746 PS00737 Thiolases signature 2. 529507008747 HMMPfam hit to PF00108, Thiolase, N-terminal domain, score 4.1e-64 529507008748 PS00098 Thiolases acyl-enzyme intermediate signature. 529507008749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 529507008750 HMMPfam hit to PF04175, Protein of unknown function (DUF406), score 4.6e-50 529507008751 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 529507008752 Signal peptide predicted for PMI1810 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 25 and 26 529507008753 HMMPfam hit to PF03349, Outer membrane protein transport protein (O, score 3.2e-165 529507008754 PS00017 ATP/GTP-binding site motif A (P-loop). 529507008755 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 529507008756 HMMPfam hit to PF04333, VacJ like lipoprotein, score 3.4e-107 529507008757 Signal peptide predicted for PMI1811 by SignalP 2.0 HMM (Signal peptide probability 0.639) with cleavage site probability 0.320 between residues 40 and 41 529507008758 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507008759 Signal peptide predicted for PMI1812 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.989 between residues 20 and 21 529507008760 1 probable transmembrane helix predicted for PMI1812 by TMHMM2.0 at aa 5-27 529507008761 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 529507008762 Signal peptide predicted for PMI1813 by SignalP 2.0 HMM (Signal peptide probability 0.623) with cleavage site probability 0.467 between residues 40 and 41 529507008763 HMMPfam hit to PF01925, Domain of unknown function DUF81, score 9.2e-15 529507008764 8 probable transmembrane helices predicted for PMI1813 by TMHMM2.0 at aa 13-35, 48-70, 82-104, 108-126, 146-168, 183-205, 212-234 and 249-266 529507008765 thiosulfate reductase PhsA; Provisional; Region: PRK15488 529507008766 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 529507008767 putative [Fe4-S4] binding site [ion binding]; other site 529507008768 putative molybdopterin cofactor binding site [chemical binding]; other site 529507008769 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 529507008770 putative molybdopterin cofactor binding site; other site 529507008771 Signal peptide predicted for PMI1814 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.985 between residues 30 and 31 529507008772 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 do, score 3.4e-15 529507008773 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 2.7e-111 529507008774 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 529507008775 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 2.1e-21 529507008776 This CDS appears to have a frame shift mutation following codon 49; thiosulfate reductase electron transport protein (pseudogene) 529507008777 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 1.1e-05 529507008778 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507008779 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.017 529507008780 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 529507008781 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 529507008782 5 probable transmembrane helices predicted for PMI1816 by TMHMM2.0 at aa 15-37, 66-85, 95-117, 170-192 and 202-224 529507008783 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 529507008784 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507008785 non-specific DNA binding site [nucleotide binding]; other site 529507008786 salt bridge; other site 529507008787 sequence-specific DNA binding site [nucleotide binding]; other site 529507008788 HMMPfam hit to PF01381, Helix-turn-helix, score 8.4e-10 529507008789 Predicted helix-turn-helix motif with score 1376.000, SD 3.87 at aa 24-45, sequence YTVFQLAKEIDISEQQLFRYER 529507008790 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 529507008791 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 529507008792 HIGH motif; other site 529507008793 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 529507008794 active site 529507008795 KMSKS motif; other site 529507008796 HMMPfam hit to PF00749, tRNA synthetases class I (E and Q), cata, score 5.2e-172 529507008797 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 529507008798 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 529507008799 classical (c) SDRs; Region: SDR_c; cd05233 529507008800 NAD(P) binding site [chemical binding]; other site 529507008801 active site 529507008802 HMMPfam hit to PF00106, short chain dehydrogenase, score 1.7e-81 529507008803 PS00061 Short-chain dehydrogenases/reductases family signature. 529507008804 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 529507008805 MarR family; Region: MarR_2; pfam12802 529507008806 HMMPfam hit to PF01047, MarR family, score 1.2e-19 529507008807 Predicted helix-turn-helix motif with score 1078.000, SD 2.86 at aa 46-67, sequence LTPSQLCEILAISRQNLSKFMR 529507008808 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 529507008809 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 529507008810 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 529507008811 Nucleoside recognition; Region: Gate; pfam07670 529507008812 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 529507008813 HMMPfam hit to PF07662, Na+ dependent nucleoside transporter C, score 4.7e-99 529507008814 9 probable transmembrane helices predicted for PMI1822 by TMHMM2.0 at aa 4-23, 30-48, 86-108, 167-189, 193-215, 241-263, 273-295, 334-356 and 371-393 529507008815 HMMPfam hit to PF07670, Nucleoside recognition, score 3.5e-14 529507008816 HMMPfam hit to PF01773, Na+ dependent nucleoside transporter N, score 5.6e-30 529507008817 Signal peptide predicted for PMI1822 by SignalP 2.0 HMM (Signal peptide probability 0.976) with cleavage site probability 0.402 between residues 21 and 22 529507008818 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 529507008819 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 529507008820 nucleotide binding pocket [chemical binding]; other site 529507008821 K-X-D-G motif; other site 529507008822 catalytic site [active] 529507008823 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 529507008824 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 529507008825 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 529507008826 Dimer interface [polypeptide binding]; other site 529507008827 BRCT sequence motif; other site 529507008828 HMMPfam hit to PF00533, BRCA1 C Terminus (BRCT) domain, score 1.6e-19 529507008829 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 0.00017 529507008830 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 3.9 529507008831 HMMPfam hit to PF03119, NAD-dependent DNA ligase C4 zinc fing, score 1.4e-11 529507008832 HMMPfam hit to PF03120, NAD-dependent DNA ligase OB-fold doma, score 2.6e-52 529507008833 PS01056 NAD-dependent DNA ligase signature 2. 529507008834 HMMPfam hit to PF01653, NAD-dependent DNA ligase adenylation, score 1e-205 529507008835 PS01055 NAD-dependent DNA ligase signature 1. 529507008836 cell division protein ZipA; Provisional; Region: PRK03427 529507008837 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 529507008838 FtsZ protein binding site [polypeptide binding]; other site 529507008839 HMMPfam hit to PF04354, ZipA, C-terminal FtsZ-binding domain, score 1.6e-71 529507008840 putative sulfate transport protein CysZ; Validated; Region: PRK04949 529507008841 4 probable transmembrane helices predicted for PMI1826 by TMHMM2.0 at aa 32-54, 69-91, 153-175 and 215-237 529507008842 HMMPfam hit to PF04401, Protein of unknown function (DUF540), score 3e-93 529507008843 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 529507008844 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 529507008845 dimer interface [polypeptide binding]; other site 529507008846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507008847 catalytic residue [active] 529507008848 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 3.1e-130 529507008849 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 529507008850 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 529507008851 dimerization domain swap beta strand [polypeptide binding]; other site 529507008852 regulatory protein interface [polypeptide binding]; other site 529507008853 active site 529507008854 regulatory phosphorylation site [posttranslational modification]; other site 529507008855 HMMPfam hit to PF00381, PTS HPr component phosphorylation site, score 3.6e-44 529507008856 PS00369 PTS HPR component histidine phosphorylation site signature. 529507008857 PS00589 PTS HPR component serine phosphorylation site signature. 529507008858 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 529507008859 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 529507008860 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 529507008861 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 529507008862 HMMPfam hit to PF05524, PEP-utilising enzyme, N-terminal, score 4.9e-54 529507008863 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile domain, score 2.5e-34 529507008864 PS00370 PEP-utilizing enzymes phosphorylation site signature. 529507008865 HMMPfam hit to PF02896, PEP-utilising enzyme, TIM barrel doma, score 6.4e-188 529507008866 PS00742 PEP-utilizing enzymes signature 2. 529507008867 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 529507008868 HPr interaction site; other site 529507008869 glycerol kinase (GK) interaction site [polypeptide binding]; other site 529507008870 active site 529507008871 phosphorylation site [posttranslational modification] 529507008872 HMMPfam hit to PF00358, phosphoenolpyruvate-dependent sugar phosph, score 5.1e-63 529507008873 PS00371 PTS EIIA domains phosphorylation site signature 1. 529507008874 cysteine synthase B; Region: cysM; TIGR01138 529507008875 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 529507008876 dimer interface [polypeptide binding]; other site 529507008877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507008878 catalytic residue [active] 529507008879 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 2.9e-107 529507008880 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 529507008881 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 529507008882 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 529507008883 Walker A/P-loop; other site 529507008884 ATP binding site [chemical binding]; other site 529507008885 Q-loop/lid; other site 529507008886 ABC transporter signature motif; other site 529507008887 Walker B; other site 529507008888 D-loop; other site 529507008889 H-loop/switch region; other site 529507008890 HMMPfam hit to PF00005, ABC transporter, score 2.8e-68 529507008891 PS00211 ABC transporters family signature. 529507008892 PS00017 ATP/GTP-binding site motif A (P-loop). 529507008893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507008894 dimer interface [polypeptide binding]; other site 529507008895 conserved gate region; other site 529507008896 putative PBP binding loops; other site 529507008897 ABC-ATPase subunit interface; other site 529507008898 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 8e-17 529507008899 5 probable transmembrane helices predicted for PMI1833 by TMHMM2.0 at aa 21-43, 63-85, 106-125, 140-162 and 246-268 529507008900 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 529507008901 sulfate transport protein; Provisional; Region: cysT; CHL00187 529507008902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507008903 dimer interface [polypeptide binding]; other site 529507008904 conserved gate region; other site 529507008905 putative PBP binding loops; other site 529507008906 ABC-ATPase subunit interface; other site 529507008907 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.7e-42 529507008908 6 probable transmembrane helices predicted for PMI1834 by TMHMM2.0 at aa 13-35, 62-84, 104-126, 136-155, 212-234 and 244-266 529507008909 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 529507008910 Signal peptide predicted for PMI1834 by SignalP 2.0 HMM (Signal peptide probability 0.862) with cleavage site probability 0.689 between residues 36 and 37 529507008911 thiosulfate transporter subunit; Provisional; Region: PRK10852 529507008912 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 529507008913 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 4.2e-08 529507008914 1 probable transmembrane helix predicted for PMI1835 by TMHMM2.0 at aa 13-35 529507008915 Signal peptide predicted for PMI1835 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 31 and 32 529507008916 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 529507008917 HMMPfam hit to PF04261, Dyp-type peroxidase family, score 4.4e-119 529507008918 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 529507008919 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 529507008920 HMMPfam hit to PF06572, Protein of unknown function (DUF1131), score 7.3e-63 529507008921 PS00430 TonB-dependent receptor proteins signature 1. 529507008922 Signal peptide predicted for PMI1837 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.578 between residues 29 and 30 529507008923 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507008924 putative acetyltransferase; Provisional; Region: PRK03624 529507008925 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 529507008926 Coenzyme A binding pocket [chemical binding]; other site 529507008927 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 7.5e-14 529507008928 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 529507008929 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 529507008930 HMMPfam hit to PF01218, Coproporphyrinogen III oxidase, score 7.9e-207 529507008931 PS01021 Coproporphyrinogen III oxidase signature. 529507008932 Signal peptide predicted for PMI1840 by SignalP 2.0 HMM (Signal peptide probability 0.681) with cleavage site probability 0.330 between residues 17 and 18 529507008933 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507008934 GTP-binding protein Der; Reviewed; Region: PRK00093 529507008935 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 529507008936 G1 box; other site 529507008937 GTP/Mg2+ binding site [chemical binding]; other site 529507008938 Switch I region; other site 529507008939 G2 box; other site 529507008940 Switch II region; other site 529507008941 G3 box; other site 529507008942 G4 box; other site 529507008943 G5 box; other site 529507008944 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 529507008945 G1 box; other site 529507008946 GTP/Mg2+ binding site [chemical binding]; other site 529507008947 Switch I region; other site 529507008948 G2 box; other site 529507008949 G3 box; other site 529507008950 Switch II region; other site 529507008951 G4 box; other site 529507008952 G5 box; other site 529507008953 HMMPfam hit to PF01926, GTPase of unknown function, score 1.8e-45 529507008954 PS00017 ATP/GTP-binding site motif A (P-loop). 529507008955 HMMPfam hit to PF01926, GTPase of unknown function, score 2.3e-45 529507008956 PS00017 ATP/GTP-binding site motif A (P-loop). 529507008957 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 529507008958 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 529507008959 Trp docking motif [polypeptide binding]; other site 529507008960 Signal peptide predicted for PMI1842 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.512 between residues 23 and 24 529507008961 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507008962 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 529507008963 1 probable transmembrane helix predicted for PMI1843 by TMHMM2.0 at aa 20-39 529507008964 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 529507008965 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 529507008966 dimer interface [polypeptide binding]; other site 529507008967 motif 1; other site 529507008968 active site 529507008969 motif 2; other site 529507008970 motif 3; other site 529507008971 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 529507008972 anticodon binding site; other site 529507008973 HMMPfam hit to PF03129, Anticodon binding domain, score 1.1e-14 529507008974 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 529507008975 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 1.9e-50 529507008976 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 529507008977 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 529507008978 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 529507008979 HMMPfam hit to PF04551, GcpE protein, score 1.6e-250 529507008980 cytoskeletal protein RodZ; Provisional; Region: PRK10856 529507008981 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507008982 non-specific DNA binding site [nucleotide binding]; other site 529507008983 salt bridge; other site 529507008984 sequence-specific DNA binding site [nucleotide binding]; other site 529507008985 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 529507008986 1 probable transmembrane helix predicted for PMI1846 by TMHMM2.0 at aa 126-148 529507008987 Predicted helix-turn-helix motif with score 1148.000, SD 3.10 at aa 43-64, sequence LTQQTVADRLCLKLTTVCEIEA 529507008988 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 529507008989 binding surface 529507008990 Tetratricopeptide repeat; Region: TPR_16; pfam13432 529507008991 TPR motif; other site 529507008992 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 1.9 529507008993 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.0051 529507008994 Signal peptide predicted for PMI1847 by SignalP 2.0 HMM (Signal peptide probability 0.985) with cleavage site probability 0.705 between residues 24 and 25 529507008995 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507008996 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 529507008997 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 529507008998 FeS/SAM binding site; other site 529507008999 HMMPfam hit to PF04055, Radical SAM superfamily, score 5.9e-19 529507009000 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 529507009001 active site 529507009002 multimer interface [polypeptide binding]; other site 529507009003 HMMPfam hit to PF00334, Nucleoside diphosphate kinase, score 4.9e-73 529507009004 PS00469 Nucleoside diphosphate kinases active site. 529507009005 penicillin-binding protein 1C; Provisional; Region: PRK11240 529507009006 Transglycosylase; Region: Transgly; pfam00912 529507009007 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cl00322 529507009008 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 529507009009 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 529507009010 HMMPfam hit to PF06832, Penicillin-Binding Protein C-terminus, score 9.6e-16 529507009011 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 3.8e-13 529507009012 PS00017 ATP/GTP-binding site motif A (P-loop). 529507009013 HMMPfam hit to PF00912, Transglycosylase, score 9.6e-82 529507009014 1 probable transmembrane helix predicted for PMI1850 by TMHMM2.0 at aa 7-26 529507009015 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 529507009016 MG2 domain; Region: A2M_N; pfam01835 529507009017 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 529507009018 surface patch; other site 529507009019 thioester region; other site 529507009020 specificity defining residues; other site 529507009021 HMMPfam hit to PF07703, Alpha-2-macroglobulin family N-terminal regi, score 1.8e-31 529507009022 PS00215 Mitochondrial energy transfer proteins signature. 529507009023 HMMPfam hit to PF01835, Alpha-2-macroglobulin family N-terminal regi, score 1.2e-78 529507009024 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507009025 SseB protein; Region: SseB; cl06279 529507009026 aminopeptidase B; Provisional; Region: PRK05015 529507009027 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 529507009028 interface (dimer of trimers) [polypeptide binding]; other site 529507009029 Substrate-binding/catalytic site; other site 529507009030 Zn-binding sites [ion binding]; other site 529507009031 HMMPfam hit to PF00883, Cytosol aminopeptidase family, catalyti, score 6.3e-155 529507009032 PS00631 Cytosol aminopeptidase signature. 529507009033 Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123 529507009034 HMMPfam hit to PF04384, Protein of unknown function (DUF528), score 1.9e-44 529507009035 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 529507009036 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 529507009037 catalytic loop [active] 529507009038 iron binding site [ion binding]; other site 529507009039 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 5.7e-25 529507009040 PS00814 Adrenodoxin family, iron-sulfur binding region signature. 529507009041 chaperone protein HscA; Provisional; Region: hscA; PRK05183 529507009042 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 529507009043 nucleotide binding site [chemical binding]; other site 529507009044 putative NEF/HSP70 interaction site [polypeptide binding]; other site 529507009045 SBD interface [polypeptide binding]; other site 529507009046 HMMPfam hit to PF00012, Hsp70 protein, score 1.1e-242 529507009047 PS01036 Heat shock hsp70 proteins family signature 3. 529507009048 PS00329 Heat shock hsp70 proteins family signature 2. 529507009049 PS00297 Heat shock hsp70 proteins family signature 1. 529507009050 co-chaperone HscB; Provisional; Region: hscB; PRK05014 529507009051 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 529507009052 HSP70 interaction site [polypeptide binding]; other site 529507009053 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 529507009054 HMMPfam hit to PF07743, HSCB C-terminal oligomerisation domain, score 4.9e-31 529507009055 HMMPfam hit to PF00226, DnaJ domain, score 1.1e-11 529507009056 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 529507009057 HMMPfam hit to PF01521, HesB-like domain, score 4.6e-56 529507009058 PS01152 Hypothetical hesB/yadR/yfhF family signature. 529507009059 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 529507009060 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 529507009061 trimerization site [polypeptide binding]; other site 529507009062 active site 529507009063 HMMPfam hit to PF01592, NifU-like N terminal domain, score 1.3e-82 529507009064 cysteine desulfurase; Provisional; Region: PRK14012 529507009065 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 529507009066 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 529507009067 catalytic residue [active] 529507009068 HMMPfam hit to PF00266, Aminotransferase class-V, score 2.3e-121 529507009069 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 529507009070 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 529507009071 Rrf2 family protein; Region: rrf2_super; TIGR00738 529507009072 HMMPfam hit to PF02082, Transcriptional regulator, score 6.8e-49 529507009073 Predicted helix-turn-helix motif with score 1222.000, SD 3.35 at aa 36-57, sequence VPLADISERQGISLSYLEQLFS 529507009074 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 529507009075 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 529507009076 HMMPfam hit to PF00588, SpoU rRNA Methylase family, score 3.4e-24 529507009077 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 529507009078 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 529507009079 active site 529507009080 dimerization interface [polypeptide binding]; other site 529507009081 HMMPfam hit to PF00459, Inositol monophosphatase family, score 7e-110 529507009082 PS00629 Inositol monophosphatase family signature 1. 529507009083 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 529507009084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 529507009085 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 529507009086 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 3.4e-07 529507009087 Predicted helix-turn-helix motif with score 1619.000, SD 4.70 at aa 34-55, sequence LRTRQLAQDAGVNQSAIPYHFG 529507009088 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 529507009089 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 529507009090 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 529507009091 active site 529507009092 HMMPfam hit to PF00557, metallopeptidase family M24, score 5.2e-05 529507009093 PS00017 ATP/GTP-binding site motif A (P-loop). 529507009094 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 529507009095 MFS_1 like family; Region: MFS_1_like; pfam12832 529507009096 12 probable transmembrane helices predicted for PMI1866 by TMHMM2.0 at aa 13-35, 45-67, 80-102, 106-128, 141-158, 163-185, 215-237, 247-269, 276-298, 302-324, 337-356 and 366-383 529507009097 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.4e-17 529507009098 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 529507009099 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 529507009100 dimer interface [polypeptide binding]; other site 529507009101 active site 529507009102 glycine-pyridoxal phosphate binding site [chemical binding]; other site 529507009103 folate binding site [chemical binding]; other site 529507009104 HMMPfam hit to PF00464, Serine hydroxymethyltransferase, score 3.2e-280 529507009105 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 529507009106 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 529507009107 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 529507009108 heme-binding site [chemical binding]; other site 529507009109 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 529507009110 FAD binding pocket [chemical binding]; other site 529507009111 FAD binding motif [chemical binding]; other site 529507009112 phosphate binding motif [ion binding]; other site 529507009113 beta-alpha-beta structure motif; other site 529507009114 NAD binding pocket [chemical binding]; other site 529507009115 Heme binding pocket [chemical binding]; other site 529507009116 HMMPfam hit to PF00042, Globin, score 4.4e-22 529507009117 HMMPfam hit to PF00970, Oxidoreductase FAD-binding domain, score 1.2e-06 529507009118 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 1.1e-13 529507009119 6 probable transmembrane helices predicted for PMI1869 by TMHMM2.0 at aa 13-35, 50-67, 74-91, 101-119, 139-161 and 183-200 529507009120 Signal peptide predicted for PMI1869 by SignalP 2.0 HMM (Signal peptide probability 0.718) with cleavage site probability 0.235 between residues 32 and 33 529507009121 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 529507009122 Nitrogen regulatory protein P-II; Region: P-II; smart00938 529507009123 HMMPfam hit to PF00543, Nitrogen regulatory protein P-II, score 6.5e-70 529507009124 PS00638 P-II protein C-terminal region signature. 529507009125 PS00496 P-II protein urydylation site. 529507009126 NAD synthetase; Provisional; Region: PRK13981 529507009127 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 529507009128 multimer interface [polypeptide binding]; other site 529507009129 active site 529507009130 catalytic triad [active] 529507009131 protein interface 1 [polypeptide binding]; other site 529507009132 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 529507009133 homodimer interface [polypeptide binding]; other site 529507009134 NAD binding pocket [chemical binding]; other site 529507009135 ATP binding pocket [chemical binding]; other site 529507009136 Mg binding site [ion binding]; other site 529507009137 active-site loop [active] 529507009138 HMMPfam hit to PF02540, NAD synthase, score 7.7e-74 529507009139 PS00307 Legume lectins beta-chain signature. 529507009140 HMMPfam hit to PF00795, Carbon-nitrogen hydrolase, score 3.4e-10 529507009141 response regulator GlrR; Provisional; Region: PRK15115 529507009142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507009143 active site 529507009144 phosphorylation site [posttranslational modification] 529507009145 intermolecular recognition site; other site 529507009146 dimerization interface [polypeptide binding]; other site 529507009147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 529507009148 Walker A motif; other site 529507009149 ATP binding site [chemical binding]; other site 529507009150 Walker B motif; other site 529507009151 arginine finger; other site 529507009152 PS00688 Sigma-54 interaction domain C-terminal part signature. 529507009153 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 2.3e-149 529507009154 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 529507009155 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 529507009156 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.7e-44 529507009157 hypothetical protein; Provisional; Region: PRK10722 529507009158 Signal peptide predicted for PMI1873 by SignalP 2.0 HMM (Signal peptide probability 0.653) with cleavage site probability 0.541 between residues 35 and 36 529507009159 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507009160 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 529507009161 HAMP domain; Region: HAMP; pfam00672 529507009162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 529507009163 dimer interface [polypeptide binding]; other site 529507009164 phosphorylation site [posttranslational modification] 529507009165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 529507009166 ATP binding site [chemical binding]; other site 529507009167 Mg2+ binding site [ion binding]; other site 529507009168 G-X-G motif; other site 529507009169 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 5.2e-22 529507009170 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 5.2e-18 529507009171 HMMPfam hit to PF00672, HAMP domain, score 4.5e-08 529507009172 2 probable transmembrane helices predicted for PMI1874 by TMHMM2.0 at aa 15-37 and 181-203 529507009173 Signal peptide predicted for PMI1874 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.848 between residues 33 and 34 529507009174 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 529507009175 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 529507009176 dimerization interface [polypeptide binding]; other site 529507009177 ATP binding site [chemical binding]; other site 529507009178 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 529507009179 dimerization interface [polypeptide binding]; other site 529507009180 ATP binding site [chemical binding]; other site 529507009181 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 529507009182 putative active site [active] 529507009183 catalytic triad [active] 529507009184 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 1.5e-23 529507009185 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 4.8e-35 529507009186 HMMPfam hit to PF00586, AIR synthase related protein, N-terminal dom, score 1.7e-37 529507009187 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 529507009188 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 529507009189 substrate binding pocket [chemical binding]; other site 529507009190 membrane-bound complex binding site; other site 529507009191 hinge residues; other site 529507009192 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 529507009193 N-acetyl-D-glucosamine binding site [chemical binding]; other site 529507009194 catalytic residue [active] 529507009195 Signal peptide predicted for PMI1876 by SignalP 2.0 HMM (Signal peptide probability 0.975) with cleavage site probability 0.759 between residues 23 and 24 529507009196 1 probable transmembrane helix predicted for PMI1876 by TMHMM2.0 at aa 7-29 529507009197 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 7.3e-17 529507009198 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 5.6e-43 529507009199 PS00922 Prokaryotic transglycosylases signature. 529507009200 fimbrial operon 9 (pmf fimbrial operon) 529507009201 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507009202 Signal peptide predicted for PMI1877 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.956 between residues 22 and 23 529507009203 HMMPfam hit to PF00419, Fimbrial protein, score 6.5e-58 529507009204 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 529507009205 PapC N-terminal domain; Region: PapC_N; pfam13954 529507009206 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 529507009207 PapC C-terminal domain; Region: PapC_C; pfam13953 529507009208 Signal peptide predicted for PMI1878 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.939 between residues 28 and 29 529507009209 HMMPfam hit to PF00577, Fimbrial Usher protein, score 0 529507009210 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 529507009211 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 529507009212 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 529507009213 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 529507009214 Signal peptide predicted for PMI1879 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.937 between residues 26 and 27 529507009215 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 4.1e-46 529507009216 PS00635 Gram-negative pili assembly chaperone signature. 529507009217 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 7.5e-08 529507009218 Fimbrial protein; Region: Fimbrial; pfam00419 529507009219 Signal peptide predicted for PMI1880 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.895 between residues 30 and 31 529507009220 1 probable transmembrane helix predicted for PMI1880 by TMHMM2.0 at aa 12-34 529507009221 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507009222 Signal peptide predicted for PMI1881 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 22 and 23 529507009223 HMMPfam hit to PF00419, Fimbrial protein, score 6.5e-28 529507009224 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 529507009225 nucleoside/Zn binding site; other site 529507009226 dimer interface [polypeptide binding]; other site 529507009227 catalytic motif [active] 529507009228 HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminase, score 3.5e-41 529507009229 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 529507009230 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 529507009231 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 1.3e-05 529507009232 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507009233 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 529507009234 HMMPfam hit to PF01648, 4'-phosphopantetheinyl transferase superfami, score 1.5e-21 529507009235 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 529507009236 active site 529507009237 hydrophilic channel; other site 529507009238 dimerization interface [polypeptide binding]; other site 529507009239 catalytic residues [active] 529507009240 active site lid [active] 529507009241 HMMPfam hit to PF03740, Pyridoxal phosphate biosynthesis protein Pdx, score 4.3e-148 529507009242 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 529507009243 Recombination protein O N terminal; Region: RecO_N; pfam11967 529507009244 Recombination protein O C terminal; Region: RecO_C; pfam02565 529507009245 HMMPfam hit to PF02565, Recombination protein O, score 1.2e-74 529507009246 GTPase Era; Reviewed; Region: era; PRK00089 529507009247 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 529507009248 G1 box; other site 529507009249 GTP/Mg2+ binding site [chemical binding]; other site 529507009250 Switch I region; other site 529507009251 G2 box; other site 529507009252 Switch II region; other site 529507009253 G3 box; other site 529507009254 G4 box; other site 529507009255 G5 box; other site 529507009256 KH domain; Region: KH_2; pfam07650 529507009257 HMMPfam hit to PF07650, KH domain, score 2.1e-25 529507009258 HMMPfam hit to PF01926, GTPase of unknown function, score 6.5e-38 529507009259 PS00017 ATP/GTP-binding site motif A (P-loop). 529507009260 ribonuclease III; Reviewed; Region: rnc; PRK00102 529507009261 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 529507009262 dimerization interface [polypeptide binding]; other site 529507009263 active site 529507009264 metal binding site [ion binding]; metal-binding site 529507009265 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 529507009266 dsRNA binding site [nucleotide binding]; other site 529507009267 HMMPfam hit to PF00035, Double-stranded RNA binding motif, score 6.2e-23 529507009268 HMMPfam hit to PF00636, RNase3 domain, score 4.4e-44 529507009269 PS00517 Ribonuclease III family signature. 529507009270 signal peptidase I; Provisional; Region: PRK10861 529507009271 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 529507009272 Catalytic site [active] 529507009273 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 529507009274 PS00761 Signal peptidases I signature 3. 529507009275 HMMPfam hit to PF00717, Peptidase S24-like, score 1e-24 529507009276 PS00760 Signal peptidases I lysine active site. 529507009277 PS00501 Signal peptidases I serine active site. 529507009278 2 probable transmembrane helices predicted for PMI1889 by TMHMM2.0 at aa 5-22 and 60-82 529507009279 GTP-binding protein LepA; Provisional; Region: PRK05433 529507009280 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 529507009281 G1 box; other site 529507009282 putative GEF interaction site [polypeptide binding]; other site 529507009283 GTP/Mg2+ binding site [chemical binding]; other site 529507009284 Switch I region; other site 529507009285 G2 box; other site 529507009286 G3 box; other site 529507009287 Switch II region; other site 529507009288 G4 box; other site 529507009289 G5 box; other site 529507009290 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 529507009291 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 529507009292 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 529507009293 HMMPfam hit to PF06421, GTP-binding protein LepA C-terminus, score 2.7e-80 529507009294 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 2.6e-31 529507009295 HMMPfam hit to PF03144, Elongation factor Tu domain, score 8e-08 529507009296 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 1.9e-71 529507009297 PS00301 GTP-binding elongation factors signature. 529507009298 PS00017 ATP/GTP-binding site motif A (P-loop). 529507009299 SoxR reducing system protein RseC; Provisional; Region: PRK10862 529507009300 HMMPfam hit to PF04246, Positive regulator of sigma(E), RseC/MucC, score 7.1e-41 529507009301 2 probable transmembrane helices predicted for PMI1891 by TMHMM2.0 at aa 78-100 and 104-121 529507009302 anti-sigma E factor; Provisional; Region: rseB; PRK09455 529507009303 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 529507009304 HMMPfam hit to PF03888, MucB/RseB family, score 2.1e-93 529507009305 1 probable transmembrane helix predicted for PMI1892 by TMHMM2.0 at aa 20-42 529507009306 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 529507009307 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 529507009308 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 529507009309 HMMPfam hit to PF03873, Anti sigma-E protein RseA, C-terminal domain, score 0.00032 529507009310 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507009311 HMMPfam hit to PF03872, Anti sigma-E protein RseA, N-terminal domain, score 5.5e-34 529507009312 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 529507009313 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 529507009314 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 529507009315 DNA binding residues [nucleotide binding] 529507009316 HMMPfam hit to PF04545, Sigma-70, region, score 4.1e-14 529507009317 Predicted helix-turn-helix motif with score 1031.000, SD 2.70 at aa 154-175, sequence LSYEEIAVIMDCPVGTVRSRIF 529507009318 HMMPfam hit to PF04542, Sigma-70 region, score 2.3e-20 529507009319 PS01063 Sigma-70 factors ECF subfamily signature. 529507009320 2 probable transmembrane helices predicted for PMI1895 by TMHMM2.0 at aa 5-27 and 50-72 529507009321 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 529507009322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507009323 S-adenosylmethionine binding site [chemical binding]; other site 529507009324 PS00092 N-6 Adenine-specific DNA methylases signature. 529507009325 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 529507009326 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 529507009327 ATP binding site [chemical binding]; other site 529507009328 Mg++ binding site [ion binding]; other site 529507009329 motif III; other site 529507009330 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 529507009331 nucleotide binding region [chemical binding]; other site 529507009332 ATP-binding site [chemical binding]; other site 529507009333 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 1.8e-68 529507009334 PS00017 ATP/GTP-binding site motif A (P-loop). 529507009335 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 529507009336 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 9.9e-31 529507009337 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 529507009338 HMMPfam hit to PF01228, Glycine radical, score 3.4e-40 529507009339 PS00850 Glycine radical signature. 529507009340 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 529507009341 ligand binding site [chemical binding]; other site 529507009342 active site 529507009343 UGI interface [polypeptide binding]; other site 529507009344 catalytic site [active] 529507009345 HMMPfam hit to PF03167, Uracil DNA glycosylase superfamily, score 4e-83 529507009346 GrpE; Region: GrpE; pfam01025 529507009347 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 529507009348 dimer interface [polypeptide binding]; other site 529507009349 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 529507009350 HMMPfam hit to PF01025, GrpE, score 3.3e-67 529507009351 PS01071 grpE protein signature. 529507009352 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 529507009353 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 529507009354 HMMPfam hit to PF01513, ATP-NAD kinase, score 3.5e-101 529507009355 recombination and repair protein; Provisional; Region: PRK10869 529507009356 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 529507009357 Walker A/P-loop; other site 529507009358 ATP binding site [chemical binding]; other site 529507009359 Q-loop/lid; other site 529507009360 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 529507009361 ABC transporter signature motif; other site 529507009362 Walker B; other site 529507009363 D-loop; other site 529507009364 H-loop/switch region; other site 529507009365 PS00017 ATP/GTP-binding site motif A (P-loop). 529507009366 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 529507009367 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 529507009368 Signal peptide predicted for PMI1903 by SignalP 2.0 HMM (Signal peptide probability 0.819) with cleavage site probability 0.521 between residues 22 and 23 529507009369 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507009370 HMMPfam hit to PF04355, SmpA / OmlA family, score 5e-35 529507009371 PS00018 EF-hand calcium-binding domain. 529507009372 hypothetical protein; Validated; Region: PRK01777 529507009373 HMMPfam hit to PF03658, Uncharacterised protein family (UPF0125), score 3e-48 529507009374 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 529507009375 putative coenzyme Q binding site [chemical binding]; other site 529507009376 HMMPfam hit to PF03364, Streptomyces cyclase/dehydrase, score 1.7e-36 529507009377 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 529507009378 SmpB-tmRNA interface; other site 529507009379 HMMPfam hit to PF01668, SmpB protein, score 1.5e-42 529507009380 PS01317 Protein smpB signature. 529507009381 S-type Pyocin; Region: Pyocin_S; pfam06958 529507009382 Colicin pore forming domain; Region: Colicin; pfam01024 529507009383 HMMPfam hit to PF01024, Colicin pore forming domain, score 1.8e-78 529507009384 2 probable transmembrane helices predicted for PMI1908 by TMHMM2.0 at aa 504-526 and 528-550 529507009385 PS00017 ATP/GTP-binding site motif A (P-loop). 529507009386 HMMPfam hit to PF06958, S-type Pyocin, score 0.00027 529507009387 PS00387 Inorganic pyrophosphatase signature. 529507009388 Colicin-E5 Imm protein; Region: ImmE5; pfam11480 529507009389 S-type Pyocin; Region: Pyocin_S; pfam06958 529507009390 Colicin C terminal ribonuclease domain; Region: Colicin_C; pfam12106 529507009391 PS00017 ATP/GTP-binding site motif A (P-loop). 529507009392 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 529507009393 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 529507009394 HMMPfam hit to PF01580, FtsK/SpoIIIE family, score 5.3e-34 529507009395 PS00017 ATP/GTP-binding site motif A (P-loop). 529507009396 Partial CDS. Similar to the C-terminal region of HsdR.; type I restriction-modification system, specificity determinant subunit (fragment) 529507009397 Partial CDS. Similar to the N-terminal region of HsdM.; type I restriction-modification system, DNA methyltransferase (fragment) 529507009398 HMMPfam hit to PF02506, Type I restriction modification system, M, score 3.8e-07 529507009399 3 probable transmembrane helices predicted for PMI1915 by TMHMM2.0 at aa 20-39, 52-73 and 83-105 529507009400 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 529507009401 This CDS appears to have a frameshift mutation following codon 87; conserved hypothetical protein (pseudogene) 529507009402 PS00017 ATP/GTP-binding site motif A (P-loop). 529507009403 Signal peptide predicted for PMI1920 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 20 and 21 529507009404 Signal peptide predicted for PMI1921 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.720 between residues 23 and 24 529507009405 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 529507009406 Signal peptide predicted for PMI1922 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21 529507009407 Signal peptide predicted for PMI1923 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.722 between residues 23 and 24 529507009408 Signal peptide predicted for PMI1924 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21 529507009409 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 529507009410 Sel1-like repeats; Region: SEL1; smart00671 529507009411 Signal peptide predicted for PMI1926 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.704 between residues 32 and 33 529507009412 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507009413 Signal peptide predicted for PMI1929 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21 529507009414 Cupin domain; Region: Cupin_2; pfam07883 529507009415 malate:quinone oxidoreductase; Validated; Region: PRK05257 529507009416 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 529507009417 HMMPfam hit to PF06039, Malate:quinone oxidoreductase (Mqo), score 4.7e-303 529507009418 Membrane transport protein; Region: Mem_trans; cl09117 529507009419 10 probable transmembrane helices predicted for PMI1932 by TMHMM2.0 at aa 5-24, 36-58, 68-90, 102-121, 126-148, 160-182, 197-216, 223-245, 255-274 and 281-303 529507009420 HMMPfam hit to PF03547, Auxin Efflux Carrier, score 6.8e-12 529507009421 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 529507009422 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 529507009423 catalytic core [active] 529507009424 1 probable transmembrane helix predicted for PMI1933 by TMHMM2.0 at aa 13-32 529507009425 Signal peptide predicted for PMI1933 by SignalP 2.0 HMM (Signal peptide probability 0.971) with cleavage site probability 0.618 between residues 19 and 20 529507009426 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 529507009427 HMMPfam hit to PF02525, Flavodoxin-like fold, score 6.7e-62 529507009428 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 529507009429 L-lactate permease; Region: Lactate_perm; cl00701 529507009430 13 probable transmembrane helices predicted for PMI1935 by TMHMM2.0 at aa 5-22, 27-49, 56-78, 118-140, 147-169, 184-206, 213-235, 239-256, 277-299, 334-356, 369-391, 395-417 and 488-507 529507009431 HMMPfam hit to PF02652, L-lactate permease, score 1.2e-131 529507009432 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 529507009433 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 529507009434 Cysteine-rich domain; Region: CCG; pfam02754 529507009435 Cysteine-rich domain; Region: CCG; pfam02754 529507009436 HMMPfam hit to PF02754, Cysteine-rich domain, score 1.7e-13 529507009437 HMMPfam hit to PF02754, Cysteine-rich domain, score 4.2e-14 529507009438 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 529507009439 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 529507009440 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 529507009441 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 529507009442 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507009443 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.0097 529507009444 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507009445 Uncharacterized conserved protein [Function unknown]; Region: COG1556 529507009446 HMMPfam hit to PF02589, Uncharacterized ACR, YkgG family COG1556, score 9.5e-64 529507009447 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 529507009448 1 probable transmembrane helix predicted for PMI1939 by TMHMM2.0 at aa 7-29 529507009449 Signal peptide predicted for PMI1939 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.996 between residues 24 and 25 529507009450 Protein of unknown function, DUF486; Region: DUF486; cl01236 529507009451 HMMPfam hit to PF04342, Protein of unknown function, DUF486, score 1.1e-47 529507009452 4 probable transmembrane helices predicted for PMI1940 by TMHMM2.0 at aa 10-29, 36-57, 72-91 and 96-113 529507009453 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 529507009454 HMMPfam hit to PF03692, Uncharacterised protein family (UPF0153), score 1.1e-19 529507009455 Domain of unknown function (DUF1287); Region: DUF1287; pfam06940 529507009456 HMMPfam hit to PF06940, Protein of unknown function (DUF1287), score 6.5e-89 529507009457 Signal peptide predicted for PMI1942 by SignalP 2.0 HMM (Signal peptide probability 0.958) with cleavage site probability 0.909 between residues 29 and 30 529507009458 putative MFS family transporter protein; Provisional; Region: PRK03633 529507009459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507009460 putative substrate translocation pore; other site 529507009461 12 probable transmembrane helices predicted for PMI1943 by TMHMM2.0 at aa 21-43, 53-72, 85-107, 111-133, 145-167, 172-191, 212-234, 249-271, 276-295, 299-321, 328-350 and 365-387 529507009462 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1e-25 529507009463 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 529507009464 Putative esterase; Region: Esterase; pfam00756 529507009465 Signal peptide predicted for PMI1944 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 18 and 19 529507009466 putative iron-regulated outer membrane virulence protein; Provisional; Region: PRK13484 529507009467 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 529507009468 N-terminal plug; other site 529507009469 ligand-binding site [chemical binding]; other site 529507009470 HMMPfam hit to PF00593, TonB dependent receptor, score 2.3e-29 529507009471 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 7.8e-27 529507009472 Signal peptide predicted for PMI1945 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 21 and 22 529507009473 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 529507009474 putative transporter; Provisional; Region: PRK10484 529507009475 Na binding site [ion binding]; other site 529507009476 substrate binding site [chemical binding]; other site 529507009477 14 probable transmembrane helices predicted for PMI1946 by TMHMM2.0 at aa 10-32, 45-67, 77-99, 131-153, 163-185, 192-214, 245-267, 288-310, 356-378, 399-421, 431-449, 456-478, 483-502 and 523-542 529507009478 HMMPfam hit to PF00474, Sodium:solute symporter family, score 3.8e-60 529507009479 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 529507009480 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 529507009481 DNA binding site [nucleotide binding] 529507009482 domain linker motif; other site 529507009483 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 529507009484 dimerization interface (closed form) [polypeptide binding]; other site 529507009485 ligand binding site [chemical binding]; other site 529507009486 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 7.2e-15 529507009487 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 5.2e-14 529507009488 Predicted helix-turn-helix motif with score 2188.000, SD 6.64 at aa 4-25, sequence ATIKDVAKEAGVSVATVSRVIN 529507009489 PS00356 Bacterial regulatory proteins, lacI family signature. 529507009490 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 529507009491 active site 529507009492 catalytic residues [active] 529507009493 HMMPfam hit to PF01263, Aldose 1-epimerase, score 1e-114 529507009494 PS00545 Aldose 1-epimerase active site. 529507009495 galactokinase; Provisional; Region: PRK05101 529507009496 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 529507009497 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 529507009498 HMMPfam hit to PF00288, GHMP kinases ATP-binding protei, score 3.5e-51 529507009499 PS00627 GHMP kinases ATP-binding domain. 529507009500 PS00106 Galactokinase signature. 529507009501 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 529507009502 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 529507009503 dimer interface [polypeptide binding]; other site 529507009504 active site 529507009505 HMMPfam hit to PF02744, Galactose-1-phosphate uridyl transfer, score 3.2e-85 529507009506 HMMPfam hit to PF01087, Galactose-1-phosphate uridyl transfer, score 5e-88 529507009507 PS00117 Galactose-1-phosphate uridyl transferase family 1 active site signature. 529507009508 UDP-glucose 4-epimerase; Region: PLN02240 529507009509 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 529507009510 NAD binding site [chemical binding]; other site 529507009511 homodimer interface [polypeptide binding]; other site 529507009512 active site 529507009513 substrate binding site [chemical binding]; other site 529507009514 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 3.9e-157 529507009515 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 529507009516 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 529507009517 dimerization interface [polypeptide binding]; other site 529507009518 ligand binding site [chemical binding]; other site 529507009519 NADP binding site [chemical binding]; other site 529507009520 catalytic site [active] 529507009521 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrog, score 5e-14 529507009522 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 1.3e-74 529507009523 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 529507009524 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 529507009525 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 529507009526 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 529507009527 HMMPfam hit to PF01545, Cation efflux family, score 1.9e-76 529507009528 4 probable transmembrane helices predicted for PMI1953 by TMHMM2.0 at aa 30-49, 97-119, 132-154 and 185-207 529507009529 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 529507009530 Ligand Binding Site [chemical binding]; other site 529507009531 HMMPfam hit to PF00582, Universal stress protein family, score 1.6e-14 529507009532 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cl00178 529507009533 secondary substrate binding site; other site 529507009534 primary substrate binding site; other site 529507009535 inhibition loop; other site 529507009536 dimerization interface [polypeptide binding]; other site 529507009537 HMMPfam hit to PF03974, Ecotin, score 2.8e-60 529507009538 Signal peptide predicted for PMI1955 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.663 between residues 21 and 22 529507009539 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507009540 Protein of unknown function (DUF465); Region: DUF465; cl01070 529507009541 HMMPfam hit to PF04325, Protein of unknown function (DUF465), score 9.7e-12 529507009542 probable metal-binding protein; Region: matur_matur; TIGR03853 529507009543 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 529507009544 DinI-like family; Region: DinI; cl11630 529507009545 HMMPfam hit to PF06183, DinI-like family, score 3.1e-10 529507009546 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 529507009547 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 529507009548 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 529507009549 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.9e-12 529507009550 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 529507009551 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 529507009552 HMMPfam hit to PF04519, Protein of unknown function, DUF583, score 3.3e-49 529507009553 2 probable transmembrane helices predicted for PMI1961 by TMHMM2.0 at aa 12-31 and 35-52 529507009554 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 529507009555 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 529507009556 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.0021 529507009557 Predicted helix-turn-helix motif with score 1183.000, SD 3.22 at aa 190-211, sequence WKLKQFAREFGMGLTTFKELFN 529507009558 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 3e-11 529507009559 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 529507009560 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 0.0015 529507009561 Signal peptide predicted for PMI1964 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.959 between residues 20 and 21 529507009562 Signal peptide predicted for PMI1965 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.572 between residues 31 and 32 529507009563 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507009564 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 529507009565 Predicted flavoprotein [General function prediction only]; Region: COG0431 529507009566 HMMPfam hit to PF03358, NADPH-dependent FMN reductase, score 6e-18 529507009567 2 probable transmembrane helices predicted for PMI1969 by TMHMM2.0 at aa 5-24 and 37-56 529507009568 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 529507009569 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 529507009570 HMMPfam hit to PF04606, Phage transcriptional activator, Ogr/Delta, score 1.9e-32 529507009571 prophage 529507009572 tail protein; Provisional; Region: D; PHA02561 529507009573 HMMPfam hit to PF05954, Phage late control gene D protein (GPD), score 2e-167 529507009574 Phage protein U [General function prediction only]; Region: COG3499 529507009575 HMMPfam hit to PF06995, Phage P2 GpU, score 7.6e-65 529507009576 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 529507009577 HMMPfam hit to PF05017, TMP repeat, score 98 529507009578 HMMPfam hit to PF05017, TMP repeat, score 4.1 529507009579 HMMPfam hit to PF05017, TMP repeat, score 30 529507009580 HMMPfam hit to PF05017, TMP repeat, score 6 529507009581 HMMPfam hit to PF05017, TMP repeat, score 1.6e+02 529507009582 HMMPfam hit to PF05017, TMP repeat, score 35 529507009583 HMMPfam hit to PF05017, TMP repeat, score 27 529507009584 3 probable transmembrane helices predicted for PMI1973 by TMHMM2.0 at aa 535-557, 564-586 and 601-623 529507009585 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 529507009586 HMMPfam hit to PF06158, Phage tail protein E, score 1.6e-38 529507009587 major tail tube protein; Provisional; Region: FII; PHA02600 529507009588 HMMPfam hit to PF04985, Phage tail tube protein FII, score 4.3e-103 529507009589 major tail sheath protein; Provisional; Region: FI; PHA02560 529507009590 HMMPfam hit to PF04984, Phage tail sheath protein, score 3.3e-167 529507009591 PS00017 ATP/GTP-binding site motif A (P-loop). 529507009592 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 529507009593 Signal peptide predicted for PMI1977 by SignalP 2.0 HMM (Signal peptide probability 0.832) with cleavage site probability 0.272 between residues 18 and 19 529507009594 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 529507009595 baseplate assembly protein; Provisional; Region: J; PHA02568 529507009596 HMMPfam hit to PF04865, Baseplate J-like protein, score 5.5e-100 529507009597 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 529507009598 HMMPfam hit to PF04965, GPW / gp25 family, score 1.9e-36 529507009599 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 529507009600 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 529507009601 HMMPfam hit to PF04717, Phage-related baseplate assembly protein, score 1.6e-41 529507009602 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 529507009603 HMMPfam hit to PF05069, Phage virion morphogenesis family, score 6.9e-15 529507009604 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 529507009605 HMMPfam hit to PF06891, P2 phage tail completion protein R (GpR), score 1.7e-49 529507009606 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 529507009607 HMMPfam hit to PF03245, Bacteriophage lysis protein, score 1.1e-08 529507009608 1 probable transmembrane helix predicted for PMI1984 by TMHMM2.0 at aa 5-27 529507009609 Signal peptide predicted for PMI1984 by SignalP 2.0 HMM (Signal peptide probability 0.737) with cleavage site probability 0.343 between residues 24 and 25 529507009610 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 529507009611 3 probable transmembrane helices predicted for PMI1986 by TMHMM2.0 at aa 15-37, 42-64 and 74-93 529507009612 Signal peptide predicted for PMI1986 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.572 between residues 33 and 34 529507009613 Phage Tail Protein X; Region: Phage_tail_X; cl02088 529507009614 HMMPfam hit to PF05489, Phage Tail Protein X, score 1.3e-27 529507009615 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 529507009616 HMMPfam hit to PF05926, Phage head completion protein (GPL), score 1.6e-64 529507009617 terminase endonuclease subunit; Provisional; Region: M; PHA02537 529507009618 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 529507009619 HMMPfam hit to PF05944, Phage small terminase subunit, score 1.4e-62 529507009620 capsid protein; Provisional; Region: N; PHA02538 529507009621 HMMPfam hit to PF05125, Phage major capsid protein, P2 family, score 1.1e-183 529507009622 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 529507009623 HMMPfam hit to PF05929, Phage capsid scaffolding protein (GPO), score 2.5e-119 529507009624 terminase ATPase subunit; Provisional; Region: P; PHA02535 529507009625 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 529507009626 HMMPfam hit to PF06056, ATPase subunit of terminase (gpP, score 0 529507009627 Predicted helix-turn-helix motif with score 1344.000, SD 3.76 at aa 21-42, sequence YRIARIAESLGEKASTIHSWKR 529507009628 portal vertex protein; Provisional; Region: Q; PHA02536 529507009629 Phage portal protein; Region: Phage_portal; pfam04860 529507009630 HMMPfam hit to PF04860, Phage portal protein, score 9e-81 529507009631 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 529507009632 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507009633 non-specific DNA binding site [nucleotide binding]; other site 529507009634 salt bridge; other site 529507009635 sequence-specific DNA binding site [nucleotide binding]; other site 529507009636 Domain of unknown function (DUF955); Region: DUF955; cl01076 529507009637 HMMPfam hit to PF06114, Domain of unknown function (DUF955), score 3.4e-14 529507009638 HMMPfam hit to PF01381, Helix-turn-helix, score 1.9e-08 529507009639 Predicted helix-turn-helix motif with score 1744.000, SD 5.13 at aa 16-37, sequence LSLEQVAERVGKTRQYIQRLES 529507009640 2 probable transmembrane helices predicted for PMI1996 by TMHMM2.0 at aa 5-22 and 37-56 529507009641 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 529507009642 HMMPfam hit to PF05840, Bacteriophage replication gene A protein (G, score 7.1e-189 529507009643 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 529507009644 HMMPfam hit to PF02086, D12 class N6 adenine-specific DNA met, score 9.7e-65 529507009645 PS00092 N-6 Adenine-specific DNA methylases signature. 529507009646 DksA-like zinc finger domain containing protein; Region: PHA00080 529507009647 HMMPfam hit to PF01258, Prokaryotic dksA/traR C4-type zinc finge, score 1.6e-16 529507009648 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 529507009649 1 probable transmembrane helix predicted for PMI2003 by TMHMM2.0 at aa 31-48 529507009650 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 529507009651 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507009652 non-specific DNA binding site [nucleotide binding]; other site 529507009653 salt bridge; other site 529507009654 sequence-specific DNA binding site [nucleotide binding]; other site 529507009655 integrase; Provisional; Region: int; PHA02601 529507009656 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 529507009657 active site 529507009658 DNA binding site [nucleotide binding] 529507009659 Int/Topo IB signature motif; other site 529507009660 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 0.068 529507009661 HMMPfam hit to PF00589, Phage integrase family, score 8.2e-35 529507009662 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 529507009663 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 529507009664 dimer interface [polypeptide binding]; other site 529507009665 putative anticodon binding site; other site 529507009666 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 529507009667 motif 1; other site 529507009668 active site 529507009669 motif 2; other site 529507009670 motif 3; other site 529507009671 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 2.9e-203 529507009672 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 529507009673 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 529507009674 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 8.2e-18 529507009675 peptide chain release factor 2; Validated; Region: prfB; PRK00578 529507009676 This domain is found in peptide chain release factors; Region: PCRF; smart00937 529507009677 RF-1 domain; Region: RF-1; pfam00472 529507009678 HMMPfam hit to PF00472, Peptidyl-tRNA hydrolase domain, score 8.2e-68 529507009679 PS00745 Prokaryotic-type class I peptide chain release factors signature. 529507009680 HMMPfam hit to PF03462, PCRF domain, score 5.7e-60 529507009681 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 529507009682 DHH family; Region: DHH; pfam01368 529507009683 DHHA1 domain; Region: DHHA1; pfam02272 529507009684 HMMPfam hit to PF02272, DHHA1 domain, score 5e-14 529507009685 HMMPfam hit to PF01368, DHH family, score 8.1e-51 529507009686 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 529507009687 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 529507009688 dimerization domain [polypeptide binding]; other site 529507009689 dimer interface [polypeptide binding]; other site 529507009690 catalytic residues [active] 529507009691 Signal peptide predicted for PMI2011 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 21 and 22 529507009692 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 529507009693 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 529507009694 active site 529507009695 Int/Topo IB signature motif; other site 529507009696 HMMPfam hit to PF00589, Phage integrase family, score 7.8e-66 529507009697 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 1.2e-32 529507009698 flavodoxin FldB; Provisional; Region: PRK12359 529507009699 HMMPfam hit to PF00258, Flavodoxin, score 1.3e-33 529507009700 PS00201 Flavodoxin signature. 529507009701 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 529507009702 HMMPfam hit to PF07254, Protein of unknown function (DUF1434), score 7.7e-28 529507009703 2 probable transmembrane helices predicted for PMI2014 by TMHMM2.0 at aa 12-34 and 38-55 529507009704 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 529507009705 HMMPfam hit to PF03937, TPR repeat region, score 5e-32 529507009706 putative global regulator; Reviewed; Region: PRK09559 529507009707 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 529507009708 HMMPfam hit to PF01571, Glycine cleavage T-protein (aminomethyl tran, score 1.3e-05 529507009709 HD domain; Region: HD_3; pfam13023 529507009710 HMMPfam hit to PF01966, HD domain, score 7.9e-05 529507009711 glycine dehydrogenase; Provisional; Region: PRK05367 529507009712 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 529507009713 tetramer interface [polypeptide binding]; other site 529507009714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507009715 catalytic residue [active] 529507009716 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 529507009717 tetramer interface [polypeptide binding]; other site 529507009718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507009719 catalytic residue [active] 529507009720 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507009721 HMMPfam hit to PF02347, Glycine cleavage system P-protein, score 6.3e-264 529507009722 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507009723 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 529507009724 lipoyl attachment site [posttranslational modification]; other site 529507009725 HMMPfam hit to PF01597, Glycine cleavage H-protein, score 5.2e-68 529507009726 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 529507009727 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 529507009728 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 529507009729 HMMPfam hit to PF01571, Glycine cleavage T-protein (aminomethyl tran, score 7.6e-122 529507009730 oxidoreductase; Provisional; Region: PRK08013 529507009731 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 529507009732 HMMPfam hit to PF01360, Monooxygenase, score 2.9e-34 529507009733 PS01304 ubiH/COQ6 monooxygenase family signature. 529507009734 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507009735 Signal peptide predicted for PMI2022 by SignalP 2.0 HMM (Signal peptide probability 0.762) with cleavage site probability 0.488 between residues 19 and 20 529507009736 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 529507009737 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 529507009738 HMMPfam hit to PF01360, Monooxygenase, score 4.8e-21 529507009739 PS01304 ubiH/COQ6 monooxygenase family signature. 529507009740 Signal peptide predicted for PMI2023 by SignalP 2.0 HMM (Signal peptide probability 0.982) with cleavage site probability 0.664 between residues 23 and 24 529507009741 proline aminopeptidase P II; Provisional; Region: PRK10879 529507009742 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 529507009743 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 529507009744 active site 529507009745 HMMPfam hit to PF00557, metallopeptidase family M24, score 2.7e-110 529507009746 PS00491 Aminopeptidase P and proline dipeptidase signature. 529507009747 HMMPfam hit to PF05195, Aminopeptidase P, N-terminal domain, score 3.5e-59 529507009748 hypothetical protein; Reviewed; Region: PRK01736 529507009749 HMMPfam hit to PF03695, Uncharacterised protein family (UPF0149), score 9.5e-69 529507009750 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 529507009751 Z-ring-associated protein; Provisional; Region: PRK10972 529507009752 HMMPfam hit to PF05164, Family of unknown function (DUF710), score 8.3e-29 529507009753 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 529507009754 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 529507009755 HMMPfam hit to PF01812, 5-formyltetrahydrofolate cyclo-ligase, score 1e-56 529507009756 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 529507009757 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 529507009758 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507009759 Walker A/P-loop; other site 529507009760 ATP binding site [chemical binding]; other site 529507009761 Q-loop/lid; other site 529507009762 ABC transporter signature motif; other site 529507009763 Walker B; other site 529507009764 D-loop; other site 529507009765 H-loop/switch region; other site 529507009766 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 9.8e-42 529507009767 5 probable transmembrane helices predicted for PMI2028 by TMHMM2.0 at aa 141-163, 167-189, 254-276, 280-297 and 376-398 529507009768 HMMPfam hit to PF00005, ABC transporter, score 1.3e-60 529507009769 PS00017 ATP/GTP-binding site motif A (P-loop). 529507009770 PS00211 ABC transporters family signature. 529507009771 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 529507009772 HlyD family secretion protein; Region: HlyD_3; pfam13437 529507009773 1 probable transmembrane helix predicted for PMI2029 by TMHMM2.0 at aa 40-62 529507009774 HMMPfam hit to PF00529, HlyD family secretion protein, score 3.4e-14 529507009775 PS00543 HlyD family secretion proteins signature. 529507009776 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 529507009777 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 529507009778 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 529507009779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507009780 Walker A/P-loop; other site 529507009781 ATP binding site [chemical binding]; other site 529507009782 Q-loop/lid; other site 529507009783 ABC transporter signature motif; other site 529507009784 Walker B; other site 529507009785 D-loop; other site 529507009786 H-loop/switch region; other site 529507009787 5 probable transmembrane helices predicted for PMI2030 by TMHMM2.0 at aa 152-174, 189-211, 263-285, 290-312 and 374-396 529507009788 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 6.8e-45 529507009789 HMMPfam hit to PF00005, ABC transporter, score 1.2e-62 529507009790 PS00017 ATP/GTP-binding site motif A (P-loop). 529507009791 PS00211 ABC transporters family signature. 529507009792 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 529507009793 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 529507009794 ligand binding site [chemical binding]; other site 529507009795 NAD binding site [chemical binding]; other site 529507009796 tetramer interface [polypeptide binding]; other site 529507009797 catalytic site [active] 529507009798 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 529507009799 L-serine binding site [chemical binding]; other site 529507009800 ACT domain interface; other site 529507009801 HMMPfam hit to PF01842, ACT domain, score 5.2e-07 529507009802 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 5.1e-92 529507009803 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 529507009804 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 529507009805 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 529507009806 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrog, score 3e-23 529507009807 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 529507009808 tetramer (dimer of dimers) interface [polypeptide binding]; other site 529507009809 active site 529507009810 dimer interface [polypeptide binding]; other site 529507009811 HMMPfam hit to PF06026, Ribose 5-phosphate isomerase A (phosph, score 4.2e-103 529507009812 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 529507009813 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507009814 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 529507009815 putative dimerization interface [polypeptide binding]; other site 529507009816 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2e-17 529507009817 Predicted helix-turn-helix motif with score 1987.000, SD 5.95 at aa 19-40, sequence RGFERAAQKLCITQSAVSQRIK 529507009818 PS00044 Bacterial regulatory proteins, lysR family signature. 529507009819 HMMPfam hit to PF03466, LysR substrate binding domain, score 3.9e-11 529507009820 Uncharacterized conserved protein [Function unknown]; Region: COG2968 529507009821 oxidative stress defense protein; Provisional; Region: PRK11087 529507009822 HMMPfam hit to PF04402, Protein of unknown function (DUF541), score 2.5e-69 529507009823 Signal peptide predicted for PMI2036 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 22 and 23 529507009824 arginine exporter protein; Provisional; Region: PRK09304 529507009825 HMMPfam hit to PF01810, LysE type translocator, score 4.6e-50 529507009826 6 probable transmembrane helices predicted for PMI2037 by TMHMM2.0 at aa 5-27, 40-62, 67-86, 111-133, 148-170 and 182-201 529507009827 Signal peptide predicted for PMI2037 by SignalP 2.0 HMM (Signal peptide probability 0.985) with cleavage site probability 0.670 between residues 26 and 27 529507009828 mechanosensitive channel MscS; Provisional; Region: PRK10334 529507009829 Conserved TM helix; Region: TM_helix; pfam05552 529507009830 Mechanosensitive ion channel; Region: MS_channel; pfam00924 529507009831 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 3.1e-79 529507009832 PS01246 Uncharacterized protein family UPF0003 signature. 529507009833 3 probable transmembrane helices predicted for PMI2038 by TMHMM2.0 at aa 20-42, 62-84 and 94-125 529507009834 HMMPfam hit to PF05552, Conserved TM helix, score 1.4e-14 529507009835 hypothetical protein; Provisional; Region: PRK05248 529507009836 HMMPfam hit to PF06062, Uncharacterised protein family (UPF0231), score 2.9e-62 529507009837 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 529507009838 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 529507009839 substrate binding site [chemical binding]; other site 529507009840 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 529507009841 substrate binding site [chemical binding]; other site 529507009842 ligand binding site [chemical binding]; other site 529507009843 HMMPfam hit to PF00330, Aconitase family (aconitate hydratase), score 2.5e-09 529507009844 PS01244 Aconitase family signature 2. 529507009845 PS00450 Aconitase family signature 1. 529507009846 HMMPfam hit to PF06434, Aconitate hydratase, score 3.4e-286 529507009847 This CDS appears to have an in-frame stop codon.; conserved hypothetical protein (pseudogene) 529507009848 C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647 529507009849 C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647 529507009850 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 529507009851 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 529507009852 Peptidase C80 family; Region: Peptidase_C80; pfam11713 529507009853 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 529507009854 HMMPfam hit to PF07634, no description, score 0.067 529507009855 HMMPfam hit to PF07634, no description, score 0.0045 529507009856 HMMPfam hit to PF07634, no description, score 1.9 529507009857 HMMPfam hit to PF07634, no description, score 1 529507009858 HMMPfam hit to PF07634, no description, score 6.6 529507009859 HMMPfam hit to PF07634, no description, score 3.3 529507009860 HMMPfam hit to PF07634, no description, score 0.029 529507009861 HMMPfam hit to PF07634, no description, score 0.045 529507009862 HMMPfam hit to PF07634, no description, score 0.4 529507009863 HMMPfam hit to PF07634, no description, score 8.9e-05 529507009864 HMMPfam hit to PF07634, no description, score 0.88 529507009865 HMMPfam hit to PF07634, no description, score 2 529507009866 HMMPfam hit to PF07634, no description, score 0.78 529507009867 HMMPfam hit to PF07634, no description, score 0.79 529507009868 HMMPfam hit to PF07634, no description, score 0.21 529507009869 HMMPfam hit to PF07634, no description, score 1.9 529507009870 HMMPfam hit to PF07634, no description, score 0.47 529507009871 HMMPfam hit to PF07634, no description, score 0.0038 529507009872 HMMPfam hit to PF07634, no description, score 0.0076 529507009873 HMMPfam hit to PF07634, no description, score 0.51 529507009874 HMMPfam hit to PF07634, no description, score 0.092 529507009875 HMMPfam hit to PF07634, no description, score 0.038 529507009876 HMMPfam hit to PF07634, no description, score 0.0085 529507009877 HMMPfam hit to PF07634, no description, score 0.28 529507009878 HMMPfam hit to PF07634, no description, score 0.41 529507009879 HMMPfam hit to PF07634, no description, score 0.0052 529507009880 HMMPfam hit to PF07634, no description, score 0.045 529507009881 HMMPfam hit to PF07634, no description, score 0.41 529507009882 HMMPfam hit to PF07634, no description, score 0.16 529507009883 HMMPfam hit to PF07634, no description, score 0.51 529507009884 HMMPfam hit to PF07634, no description, score 1.1 529507009885 HMMPfam hit to PF07634, no description, score 0.27 529507009886 HMMPfam hit to PF07634, no description, score 11 529507009887 HMMPfam hit to PF07634, no description, score 0.52 529507009888 HMMPfam hit to PF07634, no description, score 0.0086 529507009889 HMMPfam hit to PF07634, no description, score 0.0028 529507009890 HMMPfam hit to PF07634, no description, score 3.4 529507009891 HMMPfam hit to PF07634, no description, score 0.16 529507009892 HMMPfam hit to PF07634, no description, score 14 529507009893 HMMPfam hit to PF07634, no description, score 0.82 529507009894 HMMPfam hit to PF07634, no description, score 0.14 529507009895 HMMPfam hit to PF07634, no description, score 2.3 529507009896 HMMPfam hit to PF07634, no description, score 0.002 529507009897 HMMPfam hit to PF07634, no description, score 3.1 529507009898 HMMPfam hit to PF07634, no description, score 14 529507009899 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 0.0015 529507009900 HMMPfam hit to PF07634, no description, score 9.5 529507009901 HMMPfam hit to PF00353, no description, score 6.2 529507009902 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 529507009903 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 529507009904 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 529507009905 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 529507009906 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidored, score 4.1e-51 529507009907 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidored, score 2.6e-92 529507009908 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 529507009909 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 529507009910 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 529507009911 E3 interaction surface; other site 529507009912 lipoyl attachment site [posttranslational modification]; other site 529507009913 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 529507009914 E3 interaction surface; other site 529507009915 lipoyl attachment site [posttranslational modification]; other site 529507009916 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 529507009917 E3 interaction surface; other site 529507009918 lipoyl attachment site [posttranslational modification]; other site 529507009919 e3 binding domain; Region: E3_binding; pfam02817 529507009920 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 529507009921 HMMPfam hit to PF00198, 2-oxoacid dehydrogenases acyltransferas, score 1.1e-113 529507009922 HMMPfam hit to PF02817, e3 binding domain, score 7.8e-18 529507009923 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 1.4e-27 529507009924 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 529507009925 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 6.4e-27 529507009926 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 529507009927 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 5.9e-27 529507009928 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 529507009929 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 529507009930 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 529507009931 dimer interface [polypeptide binding]; other site 529507009932 TPP-binding site [chemical binding]; other site 529507009933 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 529507009934 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 529507009935 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 529507009936 DNA-binding site [nucleotide binding]; DNA binding site 529507009937 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 529507009938 HMMPfam hit to PF07729, FCD domain, score 3.5e-33 529507009939 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 5.2e-27 529507009940 PS00043 Bacterial regulatory proteins, gntR family signature. 529507009941 Predicted helix-turn-helix motif with score 1517.000, SD 4.35 at aa 40-61, sequence LPERELAKQFDVSRPSLREAIQ 529507009942 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 529507009943 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 529507009944 amidase catalytic site [active] 529507009945 substrate binding site [chemical binding]; other site 529507009946 Zn binding residues [ion binding]; other site 529507009947 HMMPfam hit to PF01510, N-acetylmuramoyl-L-alanine amidase, score 3.2e-58 529507009948 putative major pilin subunit; Provisional; Region: PRK10574 529507009949 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 4.9e-08 529507009950 1 probable transmembrane helix predicted for PMI2049 by TMHMM2.0 at aa 15-37 529507009951 Type II/IV secretion system protein; Region: T2SE; pfam00437 529507009952 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 529507009953 Walker A motif; other site 529507009954 ATP binding site [chemical binding]; other site 529507009955 Walker B motif; other site 529507009956 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 5.4e-101 529507009957 PS00017 ATP/GTP-binding site motif A (P-loop). 529507009958 Predicted helix-turn-helix motif with score 1182.000, SD 3.21 at aa 186-207, sequence INQTQITEKAGITFATILRALL 529507009959 PS00662 Bacterial type II secretion system protein E signature. 529507009960 type IV pilin biogenesis protein; Provisional; Region: PRK10573 529507009961 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 529507009962 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 529507009963 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 2.4e-14 529507009964 3 probable transmembrane helices predicted for PMI2051 by TMHMM2.0 at aa 164-186, 213-235 and 370-392 529507009965 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 3.7e-15 529507009966 PS00017 ATP/GTP-binding site motif A (P-loop). 529507009967 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 529507009968 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 529507009969 CoA-binding site [chemical binding]; other site 529507009970 ATP-binding [chemical binding]; other site 529507009971 HMMPfam hit to PF01121, Dephospho-CoA kinase, score 1.3e-97 529507009972 PS00017 ATP/GTP-binding site motif A (P-loop). 529507009973 PS01294 Uncharacterized protein family UPF0038 signature. 529507009974 hypothetical protein; Provisional; Region: PRK05287 529507009975 HMMPfam hit to PF07072, Protein of unknown function (DUF1342), score 7.6e-110 529507009976 DNA gyrase inhibitor; Reviewed; Region: PRK00418 529507009977 HMMPfam hit to PF03884, Domain of unknown function (DUF329), score 1e-31 529507009978 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 529507009979 active site 529507009980 8-oxo-dGMP binding site [chemical binding]; other site 529507009981 nudix motif; other site 529507009982 metal binding site [ion binding]; metal-binding site 529507009983 HMMPfam hit to PF00293, NUDIX domain, score 9.1e-25 529507009984 PS00893 mutT domain signature. 529507009985 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 529507009986 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 529507009987 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 529507009988 HMMPfam hit to PF03865, Haemolysin secretion/activation protein ShlB, score 0 529507009989 Signal peptide predicted for PMI2056 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.613 between residues 20 and 21 529507009990 PS00079 Multicopper oxidases signature 1. 529507009991 haemagglutination activity domain; Region: Haemagg_act; pfam05860 529507009992 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 529507009993 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 529507009994 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 529507009995 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 529507009996 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 529507009997 Signal peptide predicted for PMI2057 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.909 between residues 29 and 30 529507009998 HMMPfam hit to PF05860, haemagglutination activity domain, score 3.6e-60 529507009999 HMMPfam hit to PF05594, Haemagluttinin repeat, score 1.6 529507010000 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.42 529507010001 HMMPfam hit to PF05594, Haemagluttinin repeat, score 2.4 529507010002 HMMPfam hit to PF05594, Haemagluttinin repeat, score 1.1 529507010003 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.022 529507010004 This CDS appears to have a frameshift mutation following codon 187.; Also similar to PMI2173 (45.5 38d); copper-transporting P-type ATPase (pseudogene) 529507010005 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 3.8e-13 529507010006 PS01047 Heavy-metal-associated domain. 529507010007 Predicted helix-turn-helix motif with score 973.000, SD 2.50 at aa 77-98, sequence EEITELAIEEMTCASCVGRVEK 529507010008 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 1.8e-11 529507010009 PS01047 Heavy-metal-associated domain. 529507010010 1 probable transmembrane helix predicted for PMI2058 by TMHMM2.0 at aa 171-193 529507010011 5 probable transmembrane helices predicted for PMI2059 by TMHMM2.0 at aa 48-70, 208-230, 235-257, 551-573 and 577-599 529507010012 HMMPfam hit to PF00122, E1-E2 ATPase, score 2e-105 529507010013 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.6e-42 529507010014 PS00154 E1-E2 ATPases phosphorylation site. 529507010015 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 529507010016 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 529507010017 DNA binding residues [nucleotide binding] 529507010018 dimer interface [polypeptide binding]; other site 529507010019 copper binding site [ion binding]; other site 529507010020 Predicted helix-turn-helix motif with score 1457.000, SD 4.15 at aa 1-22, sequence MNIGQAAKKSGISSKMIRYYEQ 529507010021 HMMPfam hit to PF00376, MerR family regulatory protein, score 4.9e-14 529507010022 PS00552 Bacterial regulatory proteins, merR family signature. 529507010023 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 529507010024 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 529507010025 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 529507010026 nucleotide binding region [chemical binding]; other site 529507010027 ATP-binding site [chemical binding]; other site 529507010028 SEC-C motif; Region: SEC-C; pfam02810 529507010029 HMMPfam hit to PF02810, SEC-C motif, score 2.7e-10 529507010030 HMMPfam hit to PF07516, SecA Wing and Scaffold domain, score 4.9e-119 529507010031 Predicted helix-turn-helix motif with score 1028.000, SD 2.69 at aa 518-539, sequence SWQTEVAKLENPTEEQIEEIKA 529507010032 PS01312 Protein secA signatures. 529507010033 HMMPfam hit to PF07517, SecA DEAD-like domain, score 2.5e-161 529507010034 HMMPfam hit to PF01043, SecA preprotein cross-linking domain, score 3.6e-82 529507010035 SecA regulator SecM; Provisional; Region: PRK02943 529507010036 HMMPfam hit to PF06558, Secretion monitor precursor protein (SecM), score 3e-23 529507010037 Signal peptide predicted for PMI2062 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.879 between residues 38 and 39 529507010038 Protein of unknown function (DUF721); Region: DUF721; cl02324 529507010039 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 529507010040 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 529507010041 HMMPfam hit to PF03331, UDP-3-O-acyl N-acetylglycosamine deacetylase, score 6.5e-188 529507010042 cell division protein FtsZ; Validated; Region: PRK09330 529507010043 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 529507010044 nucleotide binding site [chemical binding]; other site 529507010045 SulA interaction site; other site 529507010046 HMMPfam hit to PF03953, Tubulin/FtsZ family, C-terminal domain, score 1.6e-45 529507010047 HMMPfam hit to PF00091, Tubulin/FtsZ family, GTPase domain, score 3.2e-89 529507010048 PS01135 FtsZ protein signature 2. 529507010049 PS01134 FtsZ protein signature 1. 529507010050 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 529507010051 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 529507010052 Cell division protein FtsA; Region: FtsA; pfam14450 529507010053 HMMPfam hit to PF02491, Cell division protein FtsA, score 1.1e-68 529507010054 HMMPfam hit to PF02491, Cell division protein FtsA, score 3e-72 529507010055 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507010056 cell division protein FtsQ; Provisional; Region: PRK10775 529507010057 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 529507010058 Cell division protein FtsQ; Region: FtsQ; pfam03799 529507010059 HMMPfam hit to PF03799, Cell division protein FtsQ, score 4.1e-58 529507010060 1 probable transmembrane helix predicted for PMI2067 by TMHMM2.0 at aa 30-52 529507010061 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 529507010062 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 529507010063 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 529507010064 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 529507010065 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 1.3e-24 529507010066 HMMPfam hit to PF01225, Mur ligase family, catalytic domain, score 3.4e-63 529507010067 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 529507010068 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 529507010069 active site 529507010070 homodimer interface [polypeptide binding]; other site 529507010071 HMMPfam hit to PF04101, Glycosyltransferase family, score 4.5e-50 529507010072 HMMPfam hit to PF03033, Glycosyltransferase family, score 1.7e-52 529507010073 Signal peptide predicted for PMI2070 by SignalP 2.0 HMM (Signal peptide probability 0.847) with cleavage site probability 0.690 between residues 26 and 27 529507010074 cell division protein FtsW; Provisional; Region: PRK10774 529507010075 HMMPfam hit to PF01098, Cell cycle protein, score 1.4e-173 529507010076 8 probable transmembrane helices predicted for PMI2071 by TMHMM2.0 at aa 32-54, 69-88, 95-117, 167-189, 202-224, 290-312, 324-346 and 356-378 529507010077 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 529507010078 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 529507010079 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 529507010080 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 529507010081 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 1.4e-14 529507010082 HMMPfam hit to PF01225, Mur ligase family, catalytic domain, score 3e-54 529507010083 PS00012 Phosphopantetheine attachment site. 529507010084 1 probable transmembrane helix predicted for PMI2072 by TMHMM2.0 at aa 9-26 529507010085 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507010086 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 529507010087 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 529507010088 Mg++ binding site [ion binding]; other site 529507010089 putative catalytic motif [active] 529507010090 putative substrate binding site [chemical binding]; other site 529507010091 10 probable transmembrane helices predicted for PMI2073 by TMHMM2.0 at aa 26-48, 69-91, 95-114, 134-151, 171-193, 200-219, 234-256, 263-285, 289-311 and 338-357 529507010092 HMMPfam hit to PF00953, Glycosyl transferase, score 1.2e-83 529507010093 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 529507010094 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 529507010095 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 529507010096 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 529507010097 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 8.5e-15 529507010098 HMMPfam hit to PF01225, Mur ligase family, catalytic domain, score 2.2e-61 529507010099 Predicted helix-turn-helix motif with score 1054.000, SD 2.78 at aa 20-41, sequence ITQSQANQLMIKSISTDSRKID 529507010100 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 529507010101 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 529507010102 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 529507010103 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 529507010104 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 4.4e-40 529507010105 HMMPfam hit to PF01225, Mur ligase family, catalytic domain, score 1.1e-73 529507010106 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 529507010107 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 529507010108 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 529507010109 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 8.8e-114 529507010110 HMMPfam hit to PF03717, Penicillin-binding Protein dimerisatio, score 1.2e-50 529507010111 Predicted helix-turn-helix motif with score 1116.000, SD 2.99 at aa 117-138, sequence SRWLALADALKLPVNQISQKIS 529507010112 1 probable transmembrane helix predicted for PMI2076 by TMHMM2.0 at aa 27-49 529507010113 Signal peptide predicted for PMI2076 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.902 between residues 45 and 46 529507010114 cell division protein FtsL; Provisional; Region: PRK10772 529507010115 HMMPfam hit to PF04999, Cell division protein FtsL, score 2.1e-49 529507010116 1 probable transmembrane helix predicted for PMI2077 by TMHMM2.0 at aa 22-39 529507010117 MraW methylase family; Region: Methyltransf_5; pfam01795 529507010118 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 529507010119 HMMPfam hit to PF01795, MraW methylase family, score 3.1e-174 529507010120 cell division protein MraZ; Reviewed; Region: PRK00326 529507010121 MraZ protein; Region: MraZ; pfam02381 529507010122 MraZ protein; Region: MraZ; pfam02381 529507010123 HMMPfam hit to PF02381, Domain of unknown function UPF0040 family, score 1.2e-22 529507010124 HMMPfam hit to PF02381, Domain of unknown function UPF0040 family, score 3.1e-26 529507010125 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 529507010126 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 529507010127 DNA binding site [nucleotide binding] 529507010128 domain linker motif; other site 529507010129 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 529507010130 dimerization interface [polypeptide binding]; other site 529507010131 ligand binding site [chemical binding]; other site 529507010132 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 7.9e-05 529507010133 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 5.8e-09 529507010134 Predicted helix-turn-helix motif with score 1821.000, SD 5.39 at aa 1-22, sequence MKLDEIARLAGVSRTTASYVIN 529507010135 PS00356 Bacterial regulatory proteins, lacI family signature. 529507010136 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 529507010137 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 529507010138 acyl-activating enzyme (AAE) consensus motif; other site 529507010139 putative AMP binding site [chemical binding]; other site 529507010140 putative active site [active] 529507010141 putative CoA binding site [chemical binding]; other site 529507010142 HMMPfam hit to PF00501, AMP-binding enzyme, score 3.5e-87 529507010143 PS00455 AMP-binding domain signature. 529507010144 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 529507010145 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507010146 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 529507010147 putative substrate binding pocket [chemical binding]; other site 529507010148 putative dimerization interface [polypeptide binding]; other site 529507010149 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.1e-12 529507010150 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 8.5e-18 529507010151 PS00044 Bacterial regulatory proteins, lysR family signature. 529507010152 Predicted helix-turn-helix motif with score 1484.000, SD 4.24 at aa 37-58, sequence QNVTRAAQVLGMSQPAVSNAVS 529507010153 2 probable transmembrane helices predicted for PMI2083 by TMHMM2.0 at aa 10-27 and 48-70 529507010154 2-isopropylmalate synthase; Validated; Region: PRK00915 529507010155 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 529507010156 active site 529507010157 catalytic residues [active] 529507010158 metal binding site [ion binding]; metal-binding site 529507010159 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 529507010160 PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1. 529507010161 HMMPfam hit to PF00682, HMGL-like, score 3.4e-145 529507010162 PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2. 529507010163 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 529507010164 tartrate dehydrogenase; Region: TTC; TIGR02089 529507010165 HMMPfam hit to PF00180, Isocitrate/isopropylmalate dehydrogenase, score 2.3e-211 529507010166 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507010167 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 529507010168 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 529507010169 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 529507010170 substrate binding site [chemical binding]; other site 529507010171 ligand binding site [chemical binding]; other site 529507010172 HMMPfam hit to PF00330, Aconitase family (aconitate hydratase), score 2.1e-271 529507010173 PS00450 Aconitase family signature 1. 529507010174 PS01244 Aconitase family signature 2. 529507010175 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 529507010176 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 529507010177 substrate binding site [chemical binding]; other site 529507010178 HMMPfam hit to PF00694, Aconitase C-terminal domain, score 1e-64 529507010179 transcriptional regulator SgrR; Provisional; Region: PRK13626 529507010180 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 529507010181 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 529507010182 Predicted helix-turn-helix motif with score 1801.000, SD 5.32 at aa 24-45, sequence TTLQELAETLHCTRRHVRSLLN 529507010183 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 3.7e-33 529507010184 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 529507010185 putative DNA-binding cleft [nucleotide binding]; other site 529507010186 putative DNA clevage site; other site 529507010187 molecular lever; other site 529507010188 HMMPfam hit to PF02976, DNA mismatch repair enzyme MutH, score 8.3e-50 529507010189 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 529507010190 Predicted helix-turn-helix motif with score 1357.000, SD 3.81 at aa 66-87, sequence GGVGVIAKKSGLSRQHIYRALS 529507010191 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 529507010192 HMMPfam hit to PF05973, Phage derived protein Gp49-like (DUF891), score 3.6e-17 529507010193 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 529507010194 acetoin reductases; Region: 23BDH; TIGR02415 529507010195 NAD binding site [chemical binding]; other site 529507010196 homotetramer interface [polypeptide binding]; other site 529507010197 homodimer interface [polypeptide binding]; other site 529507010198 active site 529507010199 substrate binding site [chemical binding]; other site 529507010200 HMMPfam hit to PF00106, short chain dehydrogenase, score 2.4e-86 529507010201 PS00061 Short-chain dehydrogenases/reductases family signature. 529507010202 PS00216 Sugar transport proteins signature 1. 529507010203 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 529507010204 agmatinase; Region: agmatinase; TIGR01230 529507010205 oligomer interface [polypeptide binding]; other site 529507010206 putative active site [active] 529507010207 Mn binding site [ion binding]; other site 529507010208 HMMPfam hit to PF00491, Arginase family, score 9.7e-118 529507010209 PS01053 Arginase family signature 3. 529507010210 PS00148 Arginase family signature 2. 529507010211 PS00147 Arginase family signature 1. 529507010212 arginine decarboxylase; Provisional; Region: PRK05354 529507010213 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 529507010214 dimer interface [polypeptide binding]; other site 529507010215 active site 529507010216 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 529507010217 catalytic residues [active] 529507010218 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 529507010219 HMMPfam hit to PF00278, Pyridoxal-dependent decarboxylase, C-, score 4.2e-43 529507010220 HMMPfam hit to PF02784, Pyridoxal-dependent decarboxylase, py, score 7.4e-107 529507010221 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 529507010222 PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 529507010223 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 529507010224 S-adenosylmethionine synthetase; Validated; Region: PRK05250 529507010225 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 529507010226 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 529507010227 HMMPfam hit to PF00438, S-adenosylmethionine synthetase, N-te, score 2.9e-63 529507010228 HMMPfam hit to PF02772, S-adenosylmethionine synthetase, cent, score 1.6e-84 529507010229 PS00376 S-adenosylmethionine synthetase signature 1. 529507010230 HMMPfam hit to PF02773, S-adenosylmethionine synthetase, C-te, score 2.2e-90 529507010231 PS00377 S-adenosylmethionine synthetase signature 2. 529507010232 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 529507010233 5 probable transmembrane helices predicted for PMI2096 by TMHMM2.0 at aa 12-34, 39-56, 63-82, 106-128 and 135-157 529507010234 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 529507010235 YhjQ protein; Region: YhjQ; pfam06564 529507010236 HMMPfam hit to PF06564, YhjQ protein, score 4.7e-16 529507010237 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 529507010238 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 529507010239 DXD motif; other site 529507010240 PilZ domain; Region: PilZ; pfam07238 529507010241 11 probable transmembrane helices predicted for PMI2099 by TMHMM2.0 at aa 35-57, 96-118, 146-168, 173-190, 197-216, 229-251, 528-550, 554-576, 639-658, 668-690 and 832-854 529507010242 HMMPfam hit to PF00535, Glycosyl transferase, score 3.6e-27 529507010243 cellulose synthase regulator protein; Provisional; Region: PRK11114 529507010244 Signal peptide predicted for PMI2100 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 19 and 20 529507010245 HMMPfam hit to PF03170, Bacterial cellulose synthase subunit, score 5e-149 529507010246 1 probable transmembrane helix predicted for PMI2100 by TMHMM2.0 at aa 729-748 529507010247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 529507010248 TPR motif; other site 529507010249 binding surface 529507010250 Tetratricopeptide repeat; Region: TPR_16; pfam13432 529507010251 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 529507010252 binding surface 529507010253 TPR motif; other site 529507010254 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 529507010255 Signal peptide predicted for PMI2101 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.821 between residues 28 and 29 529507010256 1 probable transmembrane helix predicted for PMI2101 by TMHMM2.0 at aa 12-29 529507010257 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.022; HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.17 529507010258 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 1.5 529507010259 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 8.3e-07; HMMPfam hit to PF07719, Tetratricopeptide repeat, score 9.3e-07 529507010260 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 2.5 529507010261 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.12; HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.0021 529507010262 HMMPfam hit to PF05420, Cellulose synthase operon protein C C-termin, score 1.9e-107 529507010263 Predicted transporter component [General function prediction only]; Region: COG2391 529507010264 Sulphur transport; Region: Sulf_transp; pfam04143 529507010265 HMMPfam hit to PF04143, YeeE/YedE family (DUF395), score 4e-11 529507010266 4 probable transmembrane helices predicted for PMI2102 by TMHMM2.0 at aa 7-29, 49-67, 91-113 and 118-140 529507010267 Signal peptide predicted for PMI2102 by SignalP 2.0 HMM (Signal peptide probability 0.675) with cleavage site probability 0.245 between residues 23 and 24 529507010268 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 529507010269 Predicted transporter component [General function prediction only]; Region: COG2391 529507010270 Sulphur transport; Region: Sulf_transp; pfam04143 529507010271 4 probable transmembrane helices predicted for PMI2103 by TMHMM2.0 at aa 10-32, 53-72, 82-101 and 121-143 529507010272 HMMPfam hit to PF04143, YeeE/YedE family (DUF395), score 7.9e-24 529507010273 Signal peptide predicted for PMI2103 by SignalP 2.0 HMM (Signal peptide probability 0.648) with cleavage site probability 0.346 between residues 35 and 36 529507010274 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 529507010275 dimerization interface [polypeptide binding]; other site 529507010276 putative DNA binding site [nucleotide binding]; other site 529507010277 putative Zn2+ binding site [ion binding]; other site 529507010278 HMMPfam hit to PF01022, Bacterial regulatory protein, arsR family, score 4.1e-22 529507010279 Predicted helix-turn-helix motif with score 1198.000, SD 3.27 at aa 48-69, sequence KSVSELEESLGIRQPTLSQQLT 529507010280 hypothetical protein; Provisional; Region: PRK04860 529507010281 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 529507010282 HMMPfam hit to PF03926, metallopeptidase (SprT family), score 5.6e-67 529507010283 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 529507010284 Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; pfam13957 529507010285 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 529507010286 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 529507010287 Divalent cation transporter; Region: MgtE; pfam01769 529507010288 5 probable transmembrane helices predicted for PMI2109 by TMHMM2.0 at aa 191-210, 215-237, 265-287, 292-314 and 327-349 529507010289 HMMPfam hit to PF01769, Divalent cation transporter, score 4.5e-51 529507010290 HMMPfam hit to PF00571, CBS domain, score 1.2e-08 529507010291 HMMPfam hit to PF00571, CBS domain, score 0.14 529507010292 Signal peptide predicted for PMI2110 by SignalP 2.0 HMM (Signal peptide probability 0.769) with cleavage site probability 0.370 between residues 20 and 21 529507010293 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507010294 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 529507010295 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 529507010296 FAD binding pocket [chemical binding]; other site 529507010297 FAD binding motif [chemical binding]; other site 529507010298 phosphate binding motif [ion binding]; other site 529507010299 beta-alpha-beta structure motif; other site 529507010300 NAD binding pocket [chemical binding]; other site 529507010301 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 529507010302 catalytic loop [active] 529507010303 iron binding site [ion binding]; other site 529507010304 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding doma, score 8.5e-19 529507010305 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507010306 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 529507010307 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 2.6e-06 529507010308 HMMPfam hit to PF00970, Oxidoreductase FAD-binding domain, score 9.1e-08 529507010309 hybrid cluster protein; Provisional; Region: PRK05290 529507010310 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 529507010311 ACS interaction site; other site 529507010312 CODH interaction site; other site 529507010313 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 529507010314 hybrid metal cluster; other site 529507010315 HMMPfam hit to PF03063, Prismane/CO dehydrogenase family, score 9.5e-244 529507010316 PS00017 ATP/GTP-binding site motif A (P-loop). 529507010317 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 529507010318 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 529507010319 NAD(P) binding site [chemical binding]; other site 529507010320 catalytic residues [active] 529507010321 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 1.9e-227 529507010322 PS00687 Aldehyde dehydrogenases glutamic acid active site. 529507010323 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 529507010324 amino acid carrier protein; Region: agcS; TIGR00835 529507010325 HMMPfam hit to PF01235, Sodium:alanine symporter family, score 4.6e-154 529507010326 10 probable transmembrane helices predicted for PMI2114 by TMHMM2.0 at aa 7-29, 78-100, 145-167, 180-202, 214-236, 251-270, 302-324, 350-372, 385-404 and 414-436 529507010327 PS00873 Sodium:alanine symporter family signature. 529507010328 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 529507010329 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 529507010330 Cl- selectivity filter; other site 529507010331 Cl- binding residues [ion binding]; other site 529507010332 pore gating glutamate residue; other site 529507010333 dimer interface [polypeptide binding]; other site 529507010334 H+/Cl- coupling transport residue; other site 529507010335 Signal peptide predicted for PMI2115 by SignalP 2.0 HMM (Signal peptide probability 0.761) with cleavage site probability 0.379 between residues 51 and 52 529507010336 11 probable transmembrane helices predicted for PMI2115 by TMHMM2.0 at aa 27-49, 72-94, 121-143, 176-198, 207-229, 249-271, 288-310, 314-336, 349-371, 381-403 and 416-438 529507010337 HMMPfam hit to PF00654, Voltage gated chloride channel, score 1.7e-105 529507010338 tellurite resistance protein TehB; Provisional; Region: PRK12335 529507010339 Domain of unknown function (DUF1971); Region: DUF1971; pfam09313 529507010340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507010341 S-adenosylmethionine binding site [chemical binding]; other site 529507010342 HMMPfam hit to PF03848, Tellurite resistance protein TehB, score 1.2e-75 529507010343 Ion channel; Region: Ion_trans_2; pfam07885 529507010344 TrkA-N domain; Region: TrkA_N; pfam02254 529507010345 HMMPfam hit to PF02254, TrkA-N domain, score 5.1e-07 529507010346 HMMPfam hit to PF07885, Ion channel, score 1.5e-17 529507010347 7 probable transmembrane helices predicted for PMI2117 by TMHMM2.0 at aa 21-43, 58-80, 87-106, 110-127, 139-161, 176-198 and 203-225 529507010348 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 529507010349 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 529507010350 HMMPfam hit to PF02275, Linear amide C-N hydrolases, choloylglycine, score 3.4e-37 529507010351 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507010352 Signal peptide predicted for PMI2118 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.748 between residues 28 and 29 529507010353 hypothetical protein; Provisional; Region: PRK03757 529507010354 HMMPfam hit to PF04264, YceI like family, score 3.2e-73 529507010355 Signal peptide predicted for PMI2119 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24 529507010356 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 529507010357 HMMPfam hit to PF01292, Cytochrome b561 family, score 6.5e-60 529507010358 4 probable transmembrane helices predicted for PMI2120 by TMHMM2.0 at aa 24-46, 61-79, 100-122 and 157-179 529507010359 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 529507010360 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 529507010361 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 529507010362 putative active site [active] 529507010363 Predicted helix-turn-helix motif with score 1198.000, SD 3.27 at aa 57-78, sequence DTIAILADKANVPPSTLIRFAN 529507010364 HMMPfam hit to PF01380, SIS domain, score 7.5e-15 529507010365 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 529507010366 trimer interface [polypeptide binding]; other site 529507010367 YadA-like C-terminal region; Region: YadA; pfam03895 529507010368 HMMPfam hit to PF05658, Hep_Hag, score 0.74 529507010369 HMMPfam hit to PF05658, Hep_Hag, score 4.8e-05 529507010370 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 529507010371 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 529507010372 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 529507010373 Sulfatase; Region: Sulfatase; cl17466 529507010374 Signal peptide predicted for PMI2124 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.968 between residues 27 and 28 529507010375 HMMPfam hit to PF00884, Sulfatase, score 2e-26 529507010376 Signal peptide predicted for PMI2125 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 24 and 25 529507010377 Autotransporter beta-domain; Region: Autotransporter; pfam03797 529507010378 Signal peptide predicted for PMI2126 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.983 between residues 23 and 24 529507010379 PS00017 ATP/GTP-binding site motif A (P-loop). 529507010380 HMMPfam hit to PF03797, Autotransporter beta-domain, score 1.1e-16 529507010381 Lyase, N terminal; Region: Lyase_N; pfam09092 529507010382 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 529507010383 substrate binding site [chemical binding]; other site 529507010384 catalytic residues [active] 529507010385 Signal peptide predicted for PMI2127 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.641 between residues 24 and 25 529507010386 HMMPfam hit to PF02278, Polysaccharide lyase family 8, super-sandwic, score 3.4e-07 529507010387 Lyase, N terminal; Region: Lyase_N; pfam09092 529507010388 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl17706 529507010389 substrate binding site [chemical binding]; other site 529507010390 catalytic residues [active] 529507010391 Signal peptide predicted for PMI2128 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 23 and 24 529507010392 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 529507010393 HMMPfam hit to PF07470, Glycosyl Hydrolase Family, score 1.5e-125 529507010394 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK12481 529507010395 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 529507010396 NADP binding site [chemical binding]; other site 529507010397 homodimer interface [polypeptide binding]; other site 529507010398 active site 529507010399 HMMPfam hit to PF00106, short chain dehydrogenase, score 1.4e-82 529507010400 PS00061 Short-chain dehydrogenases/reductases family signature. 529507010401 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 529507010402 HMMPfam hit to PF04962, 5-keto 4-deoxyuronate isomerase, score 3e-187 529507010403 PS00108 Serine/Threonine protein kinases active-site signature. 529507010404 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 529507010405 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 529507010406 active site 529507010407 dimer interface [polypeptide binding]; other site 529507010408 HMMPfam hit to PF01979, Amidohydrolase family, score 4e-06 529507010409 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 529507010410 active pocket/dimerization site; other site 529507010411 active site 529507010412 phosphorylation site [posttranslational modification] 529507010413 HMMPfam hit to PF03610, PTS system fructose IIA component, score 7.5e-31 529507010414 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 529507010415 HMMPfam hit to PF03613, PTS system mannose/fructose/sorbose family I, score 4.2e-78 529507010416 4 probable transmembrane helices predicted for PMI2136 by TMHMM2.0 at aa 162-184, 205-227, 242-264 and 271-293 529507010417 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 529507010418 4 probable transmembrane helices predicted for PMI2137 by TMHMM2.0 at aa 94-116, 136-158, 173-194 and 215-237 529507010419 HMMPfam hit to PF03609, PTS system sorbose-specific iic component, score 5.6e-72 529507010420 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 529507010421 active site 529507010422 phosphorylation site [posttranslational modification] 529507010423 HMMPfam hit to PF03830, PTS system sorbose subfamily IIB componen, score 9.2e-60 529507010424 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 529507010425 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 529507010426 dimer interface [polypeptide binding]; other site 529507010427 active site 529507010428 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 529507010429 putative active site [active] 529507010430 HMMPfam hit to PF01380, SIS domain, score 0.0046 529507010431 HMMPfam hit to PF01380, SIS domain, score 5.3e-05 529507010432 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 529507010433 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 529507010434 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 529507010435 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 529507010436 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 3.1e-78 529507010437 Predicted helix-turn-helix motif with score 1130.000, SD 3.04 at aa 21-42, sequence TRVEDLAELFKVSSVTIRSDLS 529507010438 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 529507010439 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 529507010440 FeS/SAM binding site; other site 529507010441 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 529507010442 HMMPfam hit to PF04055, Radical SAM superfamily, score 1.2e-15 529507010443 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 529507010444 Sulfatase; Region: Sulfatase; pfam00884 529507010445 Signal peptide predicted for PMI2143 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 28 and 29 529507010446 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507010447 HMMPfam hit to PF00884, Sulfatase, score 5.6e-44 529507010448 PS00149 Sulfatases signature 2. 529507010449 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 529507010450 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 529507010451 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 529507010452 intersubunit interface [polypeptide binding]; other site 529507010453 active site 529507010454 zinc binding site [ion binding]; other site 529507010455 Na+ binding site [ion binding]; other site 529507010456 HMMPfam hit to PF01116, Fructose-bisphosphate aldolase class-II, score 7.7e-131 529507010457 PS00602 Fructose-bisphosphate aldolase class-II signature 1. 529507010458 PS00806 Fructose-bisphosphate aldolase class-II signature 2. 529507010459 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 529507010460 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 529507010461 substrate binding site [chemical binding]; other site 529507010462 ATP binding site [chemical binding]; other site 529507010463 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 7.4e-62 529507010464 PS00584 pfkB family of carbohydrate kinases signature 2. 529507010465 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 529507010466 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 529507010467 active site 529507010468 intersubunit interface [polypeptide binding]; other site 529507010469 catalytic residue [active] 529507010470 HMMPfam hit to PF01081, KDPG and KHG aldolase, score 2.3e-83 529507010471 PS00160 KDPG and KHG aldolases Schiff-base forming residue. 529507010472 DJ-1 family protein; Region: not_thiJ; TIGR01383 529507010473 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 529507010474 conserved cys residue [active] 529507010475 HMMPfam hit to PF01965, DJ-1/PfpI family, score 2e-15 529507010476 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 529507010477 hydroxyglutarate oxidase; Provisional; Region: PRK11728 529507010478 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 2.2e-72 529507010479 Signal peptide predicted for PMI2149 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.712 between residues 21 and 22 529507010480 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 529507010481 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 529507010482 HMMPfam hit to PF02567, Phenazine biosynthesis-like protein, score 7e-49 529507010483 arsenical pump membrane protein; Provisional; Region: PRK15445 529507010484 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 529507010485 transmembrane helices; other site 529507010486 10 probable transmembrane helices predicted for PMI2152 by TMHMM2.0 at aa 7-26, 30-49, 56-78, 105-139, 146-168, 183-205, 236-270, 285-304, 324-343 and 414-436 529507010487 HMMPfam hit to PF02040, Arsenical pump membrane protein, score 0 529507010488 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 529507010489 dimerization interface [polypeptide binding]; other site 529507010490 putative DNA binding site [nucleotide binding]; other site 529507010491 putative Zn2+ binding site [ion binding]; other site 529507010492 HMMPfam hit to PF01022, Bacterial regulatory protein, arsR family, score 4.3e-24 529507010493 PS00846 Bacterial regulatory proteins, arsR family signature. 529507010494 Signal peptide predicted for PMI2154 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21 529507010495 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 529507010496 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 529507010497 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 529507010498 homodimer interface [polypeptide binding]; other site 529507010499 NADP binding site [chemical binding]; other site 529507010500 substrate binding site [chemical binding]; other site 529507010501 PS00017 ATP/GTP-binding site motif A (P-loop). 529507010502 HMMPfam hit to PF00763, Tetrahydrofolate dehydrogenase/cyclohyd, score 4.8e-68 529507010503 HMMPfam hit to PF02882, Tetrahydrofolate dehydrogenase/cyclohyd, score 2.7e-104 529507010504 PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. 529507010505 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507010506 ribosome-associated protein; Provisional; Region: PRK11507 529507010507 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 529507010508 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 529507010509 putative substrate binding site [chemical binding]; other site 529507010510 putative ATP binding site [chemical binding]; other site 529507010511 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 3.1e-55 529507010512 PS00583 pfkB family of carbohydrate kinases signature 1. 529507010513 PS00584 pfkB family of carbohydrate kinases signature 2. 529507010514 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 529507010515 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 529507010516 active site 529507010517 HIGH motif; other site 529507010518 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 529507010519 KMSKS motif; other site 529507010520 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 529507010521 tRNA binding surface [nucleotide binding]; other site 529507010522 anticodon binding site; other site 529507010523 HMMPfam hit to PF01406, tRNA synthetases class I (C) catalytic d, score 9.4e-208 529507010524 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 529507010525 substrate binding site [chemical binding]; other site 529507010526 HMMPfam hit to PF00160, Cyclophilin type peptidyl-prolyl cis-tr, score 2.1e-51 529507010527 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 529507010528 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 529507010529 putative active site [active] 529507010530 putative metal binding site [ion binding]; other site 529507010531 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 1.7e-11 529507010532 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 529507010533 HMMPfam hit to PF00731, AIR carboxylase, score 1.5e-98 529507010534 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 529507010535 ATP-grasp domain; Region: ATP-grasp; pfam02222 529507010536 HMMPfam hit to PF02222, ATP-grasp domain, score 8.5e-16 529507010537 Major Facilitator Superfamily; Region: MFS_1; pfam07690 529507010538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507010539 putative substrate translocation pore; other site 529507010540 Signal peptide predicted for PMI2163 by SignalP 2.0 HMM (Signal peptide probability 0.618) with cleavage site probability 0.409 between residues 29 and 30 529507010541 12 probable transmembrane helices predicted for PMI2163 by TMHMM2.0 at aa 16-38, 53-75, 82-99, 109-131, 138-160, 170-192, 231-253, 263-285, 297-319, 324-346, 353-375 and 380-402 529507010542 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 9.1e-25 529507010543 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 529507010544 Mechanosensitive ion channel; Region: MS_channel; pfam00924 529507010545 Signal peptide predicted for PMI2164 by SignalP 2.0 HMM (Signal peptide probability 0.279) with cleavage site probability 0.173 between residues 29 and 30 529507010546 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507010547 4 probable transmembrane helices predicted for PMI2164 by TMHMM2.0 at aa 5-22, 34-53, 68-90 and 111-133 529507010548 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 3.6e-72 529507010549 PS01246 Uncharacterized protein family UPF0003 signature. 529507010550 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 529507010551 FtsX-like permease family; Region: FtsX; pfam02687 529507010552 HMMPfam hit to PF02687, Predicted permease, score 4.1e-09 529507010553 10 probable transmembrane helices predicted for PMI2165 by TMHMM2.0 at aa 13-35, 245-264, 293-315, 335-355, 383-405, 409-431, 452-474, 691-713, 740-762 and 777-799 529507010554 HMMPfam hit to PF02687, Predicted permease, score 1.5e-16 529507010555 HMMPfam hit to PF03929, no description, score 2.8 529507010556 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507010557 Signal peptide predicted for PMI2165 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.437 between residues 27 and 28 529507010558 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 529507010559 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 529507010560 Walker A/P-loop; other site 529507010561 ATP binding site [chemical binding]; other site 529507010562 Q-loop/lid; other site 529507010563 ABC transporter signature motif; other site 529507010564 Walker B; other site 529507010565 D-loop; other site 529507010566 H-loop/switch region; other site 529507010567 HMMPfam hit to PF00005, ABC transporter, score 3.8e-51 529507010568 PS00211 ABC transporters family signature. 529507010569 PS00017 ATP/GTP-binding site motif A (P-loop). 529507010570 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 529507010571 active site 529507010572 catalytic triad [active] 529507010573 oxyanion hole [active] 529507010574 switch loop; other site 529507010575 Signal peptide predicted for PMI2167 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 26 and 27 529507010576 1 probable transmembrane helix predicted for PMI2167 by TMHMM2.0 at aa 12-34 529507010577 HMMPfam hit to PF00657, GDSL-like Lipase/Acylhydrolase, score 5.3e-30 529507010578 PS01098 Lipolytic enzymes G-D-S-L family, serine active site. 529507010579 oxidoreductase; Provisional; Region: PRK08017 529507010580 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 529507010581 NADP binding site [chemical binding]; other site 529507010582 active site 529507010583 steroid binding site; other site 529507010584 Signal peptide predicted for PMI2168 by SignalP 2.0 HMM (Signal peptide probability 0.852) with cleavage site probability 0.769 between residues 19 and 20 529507010585 HMMPfam hit to PF00106, short chain dehydrogenase, score 5.9e-46 529507010586 PS00061 Short-chain dehydrogenases/reductases family signature. 529507010587 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 529507010588 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 529507010589 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 529507010590 TPR motif; other site 529507010591 binding surface 529507010592 HMMPfam hit to PF00085, Thioredoxin, score 9.3e-12 529507010593 HMMPfam hit to PF07719, no description, score 0.022 529507010594 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 529507010595 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 529507010596 1 probable transmembrane helix predicted for PMI2170 by TMHMM2.0 at aa 7-29 529507010597 HMMPfam hit to PF01145, SPFH domain / Band, score 1.1e-74 529507010598 PS01270 Band 7 protein family signature. 529507010599 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 529507010600 3 probable transmembrane helices predicted for PMI2171 by TMHMM2.0 at aa 4-23, 30-49 and 53-75 529507010601 HMMPfam hit to PF01957, Nodulation efficiency protein D (NfeD), score 1.6e-36 529507010602 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 529507010603 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 529507010604 DNA binding residues [nucleotide binding] 529507010605 dimer interface [polypeptide binding]; other site 529507010606 copper binding site [ion binding]; other site 529507010607 HMMPfam hit to PF00376, MerR family regulatory protein, score 8.2e-12 529507010608 PS00552 Bacterial regulatory proteins, merR family signature. 529507010609 Predicted helix-turn-helix motif with score 1498.000, SD 4.29 at aa 1-22, sequence MNISEIATKTGLTTKAIRFYEE 529507010610 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 529507010611 metal-binding site [ion binding] 529507010612 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 529507010613 metal-binding site [ion binding] 529507010614 copper exporting ATPase; Provisional; Region: copA; PRK10671 529507010615 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 529507010616 metal-binding site [ion binding] 529507010617 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 529507010618 metal-binding site [ion binding] 529507010619 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 529507010620 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 529507010621 motif II; other site 529507010622 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 0.00057 529507010623 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 7.1e-07 529507010624 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 5.6e-11 529507010625 PS01047 Heavy-metal-associated domain. 529507010626 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 1e-14 529507010627 PS01047 Heavy-metal-associated domain. 529507010628 8 probable transmembrane helices predicted for PMI2173 by TMHMM2.0 at aa 339-356, 366-388, 401-423, 433-452, 586-608, 613-635, 928-947 and 952-974 529507010629 HMMPfam hit to PF00122, E1-E2 ATPase, score 5.8e-89 529507010630 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 7e-38 529507010631 PS00154 E1-E2 ATPases phosphorylation site. 529507010632 PS01229 Hypothetical cof family signature 2. 529507010633 Predicted helix-turn-helix motif with score 1358.000, SD 3.81 at aa 905-926, sequence HSLHGVADAVEISKGTLRNMKQ 529507010634 YadA-like C-terminal region; Region: YadA; pfam03895 529507010635 Signal peptide predicted for PMI2174 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.990 between residues 21 and 22 529507010636 HMMPfam hit to PF03895, YadA-like C-terminal region, score 6.4e-07 529507010637 TraB family; Region: TraB; cl12050 529507010638 HMMPfam hit to PF07446, GumN protein, score 9.5e-07 529507010639 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 529507010640 putative deacylase active site [active] 529507010641 HMMPfam hit to PF04073, YbaK / prolyl-tRNA synthetases associated do, score 1.1e-67 529507010642 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 529507010643 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 529507010644 active site 529507010645 metal binding site [ion binding]; metal-binding site 529507010646 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 529507010647 HMMPfam hit to PF02872, 5'-nucleotidase, C-terminal domain, score 7.7e-45 529507010648 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 2.1e-21 529507010649 PS00786 5'-nucleotidase signature 2. 529507010650 PS00785 5'-nucleotidase signature 1. 529507010651 Signal peptide predicted for PMI2177 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.585 between residues 25 and 26 529507010652 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 529507010653 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 529507010654 Probable transposase; Region: OrfB_IS605; pfam01385 529507010655 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 529507010656 HMMPfam hit to PF01385, Probable transposase, score 1.4e-129 529507010657 Transposase IS200 like; Region: Y1_Tnp; pfam01797 529507010658 HMMPfam hit to PF01797, Transposase IS200 like, score 5.3e-25 529507010659 putative cation:proton antiport protein; Provisional; Region: PRK10669 529507010660 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 529507010661 TrkA-N domain; Region: TrkA_N; pfam02254 529507010662 11 probable transmembrane helices predicted for PMI2180 by TMHMM2.0 at aa 4-23, 30-52, 56-78, 87-109, 114-136, 149-171, 186-208, 228-247, 303-325, 337-359 and 369-388 529507010663 PS00017 ATP/GTP-binding site motif A (P-loop). 529507010664 HMMPfam hit to PF02254, TrkA-N domain, score 1.3e-25 529507010665 inosine/guanosine kinase; Provisional; Region: PRK15074 529507010666 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 529507010667 substrate binding site [chemical binding]; other site 529507010668 ATP binding site [chemical binding]; other site 529507010669 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 9.5e-26 529507010670 PS00584 pfkB family of carbohydrate kinases signature 2. 529507010671 LPS O-antigen length regulator; Provisional; Region: PRK10381 529507010672 Chain length determinant protein; Region: Wzz; pfam02706 529507010673 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 529507010674 3 probable transmembrane helices predicted for PMI2182 by TMHMM2.0 at aa 10-27, 86-108 and 384-406 529507010675 HMMPfam hit to PF02706, Chain length determinant protein, score 1.2e-17 529507010676 PS00141 Eukaryotic and viral aspartyl proteases active site. 529507010677 ferrochelatase; Reviewed; Region: hemH; PRK00035 529507010678 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 529507010679 C-terminal domain interface [polypeptide binding]; other site 529507010680 active site 529507010681 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 529507010682 active site 529507010683 N-terminal domain interface [polypeptide binding]; other site 529507010684 HMMPfam hit to PF00762, Ferrochelatase, score 3.8e-127 529507010685 PS00534 Ferrochelatase signature. 529507010686 adenylate kinase; Reviewed; Region: adk; PRK00279 529507010687 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 529507010688 AMP-binding site [chemical binding]; other site 529507010689 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 529507010690 HMMPfam hit to PF00406, Adenylate kinase, score 1.8e-93 529507010691 HMMPfam hit to PF05191, Adenylate kinase, active site lid, score 1.2e-19 529507010692 PS00113 Adenylate kinase signature. 529507010693 heat shock protein 90; Provisional; Region: PRK05218 529507010694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 529507010695 ATP binding site [chemical binding]; other site 529507010696 Mg2+ binding site [ion binding]; other site 529507010697 G-X-G motif; other site 529507010698 HMMPfam hit to PF00183, Hsp90 protein, score 2.3e-91 529507010699 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 5.7e-18 529507010700 PS00298 Heat shock hsp90 proteins family signature. 529507010701 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 529507010702 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 529507010703 ATP-grasp domain; Region: ATP-grasp; pfam02222 529507010704 HMMPfam hit to PF02222, ATP-grasp domain, score 5.4e-26 529507010705 EamA-like transporter family; Region: EamA; cl17759 529507010706 Predicted permeases [General function prediction only]; Region: RarD; COG2962 529507010707 9 probable transmembrane helices predicted for PMI2188 by TMHMM2.0 at aa 30-52, 59-78, 93-115, 120-142, 166-188, 197-219, 234-253, 260-282 and 292-309 529507010708 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1e-08 529507010709 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 529507010710 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 529507010711 putative substrate binding site [chemical binding]; other site 529507010712 putative ATP binding site [chemical binding]; other site 529507010713 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 3.4e-77 529507010714 PS00584 pfkB family of carbohydrate kinases signature 2. 529507010715 PS00583 pfkB family of carbohydrate kinases signature 1. 529507010716 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 529507010717 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 529507010718 substrate binding [chemical binding]; other site 529507010719 active site 529507010720 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 529507010721 HMMPfam hit to PF00251, Glycosyl hydrolases family, score 4.5e-166 529507010722 Transcriptional regulators [Transcription]; Region: PurR; COG1609 529507010723 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 529507010724 DNA binding site [nucleotide binding] 529507010725 domain linker motif; other site 529507010726 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 529507010727 putative ligand binding site [chemical binding]; other site 529507010728 putative dimerization interface [polypeptide binding]; other site 529507010729 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 5.1e-47 529507010730 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 7e-11 529507010731 Predicted helix-turn-helix motif with score 1737.000, SD 5.10 at aa 2-23, sequence ASLKDVARLASVSLMTVSRAIN 529507010732 PS00356 Bacterial regulatory proteins, lacI family signature. 529507010733 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 529507010734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507010735 active site 529507010736 dimerization interface [polypeptide binding]; other site 529507010737 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 529507010738 DNA binding residues [nucleotide binding] 529507010739 dimerization interface [polypeptide binding]; other site 529507010740 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR family, score 3.9e-23 529507010741 Predicted helix-turn-helix motif with score 1237.000, SD 3.40 at aa 161-182, sequence NTSKEAAEKLSLSPRTVEVHRS 529507010742 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 529507010743 Signal peptide predicted for PMI2193 by SignalP 2.0 HMM (Signal peptide probability 0.931) with cleavage site probability 0.802 between residues 58 and 59 529507010744 4 probable transmembrane helices predicted for PMI2193 by TMHMM2.0 at aa 34-56, 60-79, 112-134 and 185-207 529507010745 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 0.00093 529507010746 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 529507010747 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 529507010748 putative acyl-acceptor binding pocket; other site 529507010749 HMMPfam hit to PF01553, Acyltransferase, score 1.2e-09 529507010750 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 529507010751 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 529507010752 Signal peptide predicted for PMI2195 by SignalP 2.0 HMM (Signal peptide probability 0.844) with cleavage site probability 0.567 between residues 30 and 31 529507010753 8 probable transmembrane helices predicted for PMI2195 by TMHMM2.0 at aa 10-32, 52-74, 94-111, 118-136, 151-173, 180-202, 222-240 and 247-269 529507010754 HMMPfam hit to PF01148, Cytidylyltransferase family, score 6e-78 529507010755 CAAX protease self-immunity; Region: Abi; pfam02517 529507010756 Signal peptide predicted for PMI2196 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.593 between residues 21 and 22 529507010757 7 probable transmembrane helices predicted for PMI2196 by TMHMM2.0 at aa 20-52, 65-87, 107-129, 142-164, 168-185, 206-238 and 248-270 529507010758 HMMPfam hit to PF02517, CAAX amino terminal protease family, score 4.1e-14 529507010759 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 529507010760 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507010761 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 529507010762 dimerization interface [polypeptide binding]; other site 529507010763 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.8e-21 529507010764 Predicted helix-turn-helix motif with score 1405.000, SD 3.97 at aa 46-67, sequence QSFTKAAEMLHKTSAAISYRIK 529507010765 HMMPfam hit to PF03466, LysR substrate binding domain, score 3.9e-10 529507010766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507010767 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 529507010768 putative substrate translocation pore; other site 529507010769 HMMPfam hit to PF00083, Sugar (and other) transporter, score 1.4e-05 529507010770 11 probable transmembrane helices predicted for PMI2198 by TMHMM2.0 at aa 20-42, 55-77, 97-119, 140-162, 177-195, 227-249, 264-286, 293-310, 320-342, 355-377 and 387-404 529507010771 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.7e-58 529507010772 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 529507010773 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 529507010774 putative substrate binding site [chemical binding]; other site 529507010775 nucleotide binding site [chemical binding]; other site 529507010776 nucleotide binding site [chemical binding]; other site 529507010777 homodimer interface [polypeptide binding]; other site 529507010778 HMMPfam hit to PF00696, Amino acid kinase family, score 9.4e-78 529507010779 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 529507010780 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 529507010781 HMMPfam hit to PF06545, Protein of unknown function (DUF1116), score 1.9e-280 529507010782 membrane protein FdrA; Validated; Region: PRK06091 529507010783 CoA binding domain; Region: CoA_binding; pfam02629 529507010784 CoA-ligase; Region: Ligase_CoA; pfam00549 529507010785 HMMPfam hit to PF06263, Bacterial FdrA protein, score 9.6e-277 529507010786 PS00213 Lipocalin signature. 529507010787 Isochorismatase family; Region: Isochorismatase; pfam00857 529507010788 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 529507010789 catalytic triad [active] 529507010790 dimer interface [polypeptide binding]; other site 529507010791 conserved cis-peptide bond; other site 529507010792 HMMPfam hit to PF00857, Isochorismatase family, score 1.6e-17 529507010793 Pirin-related protein [General function prediction only]; Region: COG1741 529507010794 Pirin; Region: Pirin; pfam02678 529507010795 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 529507010796 HMMPfam hit to PF02678, Pirin, score 4.6e-49 529507010797 HMMPfam hit to PF05726, Pirin C-terminal region, score 1.6e-36 529507010798 LysR family transcriptional regulator; Provisional; Region: PRK14997 529507010799 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507010800 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 529507010801 putative effector binding pocket; other site 529507010802 putative dimerization interface [polypeptide binding]; other site 529507010803 HMMPfam hit to PF03466, LysR substrate binding domain, score 6.1e-39 529507010804 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.7e-15 529507010805 Predicted helix-turn-helix motif with score 1396.000, SD 3.94 at aa 18-39, sequence GGFSQAAETLGIPKSKLSRRIA 529507010806 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 529507010807 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 529507010808 transmembrane helices; other site 529507010809 HMMPfam hit to PF00939, Sodium:sulfate symporter transmembrane, score 7.1e-182 529507010810 12 probable transmembrane helices predicted for PMI2206 by TMHMM2.0 at aa 13-32, 47-69, 90-107, 117-139, 193-215, 230-252, 273-295, 310-329, 342-361, 376-398, 410-432 and 465-487 529507010811 fimbrial operon 10 529507010812 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 529507010813 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507010814 non-specific DNA binding site [nucleotide binding]; other site 529507010815 salt bridge; other site 529507010816 sequence-specific DNA binding site [nucleotide binding]; other site 529507010817 HMMPfam hit to PF01381, Helix-turn-helix, score 1.1e-08 529507010818 Predicted helix-turn-helix motif with score 1545.000, SD 4.45 at aa 39-60, sequence MTGSELGALLGVSQQHQSRFEN 529507010819 putative major fimbrial protein SthE; Provisional; Region: PRK15292 529507010820 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507010821 HMMPfam hit to PF00419, Fimbrial protein, score 7.5e-09 529507010822 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507010823 Signal peptide predicted for PMI2208 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.951 between residues 24 and 25 529507010824 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 529507010825 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507010826 non-specific DNA binding site [nucleotide binding]; other site 529507010827 salt bridge; other site 529507010828 sequence-specific DNA binding site [nucleotide binding]; other site 529507010829 HMMPfam hit to PF01381, Helix-turn-helix, score 5.7e-13 529507010830 Predicted helix-turn-helix motif with score 2304.000, SD 7.03 at aa 40-61, sequence LTLSELAKKIGISQQQQSRYER 529507010831 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507010832 HMMPfam hit to PF00419, Fimbrial protein, score 3.1e-07 529507010833 Signal peptide predicted for PMI2210 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.992 between residues 19 and 20 529507010834 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507010835 HMMPfam hit to PF00419, Fimbrial protein, score 2.3e-16 529507010836 1 probable transmembrane helix predicted for PMI2211 by TMHMM2.0 at aa 7-29 529507010837 Signal peptide predicted for PMI2211 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.784 between residues 22 and 23 529507010838 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 529507010839 PapC N-terminal domain; Region: PapC_N; pfam13954 529507010840 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 529507010841 PapC C-terminal domain; Region: PapC_C; pfam13953 529507010842 HMMPfam hit to PF00577, Fimbrial Usher protein, score 0 529507010843 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 529507010844 Signal peptide predicted for PMI2212 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.955 between residues 22 and 23 529507010845 putative chaperone protein EcpD; Provisional; Region: PRK09926 529507010846 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 529507010847 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 529507010848 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 2.7e-13 529507010849 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 8.6e-54 529507010850 PS00635 Gram-negative pili assembly chaperone signature. 529507010851 1 probable transmembrane helix predicted for PMI2213 by TMHMM2.0 at aa 4-26 529507010852 Signal peptide predicted for PMI2213 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.972 between residues 19 and 20 529507010853 Fimbrial protein; Region: Fimbrial; cl01416 529507010854 HMMPfam hit to PF00419, Fimbrial protein, score 3.1e-42 529507010855 Signal peptide predicted for PMI2214 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 23 and 24 529507010856 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 529507010857 HMMPfam hit to PF04261, Dyp-type peroxidase family, score 8.7e-92 529507010858 fimbrial operon 11 529507010859 Signal peptide predicted for PMI2216 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.770 between residues 20 and 21 529507010860 Fimbrial protein; Region: Fimbrial; pfam00419 529507010861 Signal peptide predicted for PMI2217 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.999 between residues 22 and 23 529507010862 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507010863 HMMPfam hit to PF00419, Fimbrial protein, score 8.4e-11 529507010864 1 probable transmembrane helix predicted for PMI2218 by TMHMM2.0 at aa 12-31 529507010865 Signal peptide predicted for PMI2218 by SignalP 2.0 HMM (Signal peptide probability 0.964) with cleavage site probability 0.872 between residues 25 and 26 529507010866 1 probable transmembrane helix predicted for PMI2219 by TMHMM2.0 at aa 7-29 529507010867 Signal peptide predicted for PMI2219 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.995 between residues 25 and 26 529507010868 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 529507010869 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 529507010870 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 529507010871 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 3.8e-12 529507010872 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 4.3e-44 529507010873 PS00635 Gram-negative pili assembly chaperone signature. 529507010874 Signal peptide predicted for PMI2220 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 19 and 20 529507010875 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 529507010876 PapC N-terminal domain; Region: PapC_N; pfam13954 529507010877 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 529507010878 PapC C-terminal domain; Region: PapC_C; pfam13953 529507010879 HMMPfam hit to PF00577, Fimbrial Usher protein, score 5.2e-285 529507010880 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 529507010881 Signal peptide predicted for PMI2221 by SignalP 2.0 HMM (Signal peptide probability 0.957) with cleavage site probability 0.955 between residues 23 and 24 529507010882 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507010883 HMMPfam hit to PF00419, Fimbrial protein, score 2.1e-11 529507010884 Signal peptide predicted for PMI2222 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.844 between residues 21 and 22 529507010885 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507010886 HMMPfam hit to PF00419, Fimbrial protein, score 3.7e-37 529507010887 Signal peptide predicted for PMI2223 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.979 between residues 23 and 24 529507010888 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507010889 non-specific DNA binding site [nucleotide binding]; other site 529507010890 salt bridge; other site 529507010891 sequence-specific DNA binding site [nucleotide binding]; other site 529507010892 HMMPfam hit to PF01381, Helix-turn-helix, score 1.5e-12 529507010893 Predicted helix-turn-helix motif with score 2046.000, SD 6.16 at aa 31-52, sequence LTGAQLGELLDVSQQQISRYEN 529507010894 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 529507010895 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 529507010896 active site 529507010897 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 529507010898 HMMPfam hit to PF02231, PHP domain N-terminal region, score 1.2e-15 529507010899 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 529507010900 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 529507010901 active site turn [active] 529507010902 phosphorylation site [posttranslational modification] 529507010903 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 529507010904 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 529507010905 HPr interaction site; other site 529507010906 glycerol kinase (GK) interaction site [polypeptide binding]; other site 529507010907 active site 529507010908 phosphorylation site [posttranslational modification] 529507010909 HMMPfam hit to PF00358, phosphoenolpyruvate-dependent sugar phosph, score 2.9e-49 529507010910 8 probable transmembrane helices predicted for PMI2226 by TMHMM2.0 at aa 114-136, 143-165, 210-232, 239-261, 276-298, 353-375, 390-412 and 425-447 529507010911 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 4.8e-39 529507010912 HMMPfam hit to PF00367, phosphotransferase system, EIIB, score 1e-14 529507010913 transcriptional antiterminator BglG; Provisional; Region: PRK09772 529507010914 CAT RNA binding domain; Region: CAT_RBD; smart01061 529507010915 PRD domain; Region: PRD; pfam00874 529507010916 PRD domain; Region: PRD; pfam00874 529507010917 HMMPfam hit to PF00874, PRD domain, score 9.4e-12 529507010918 HMMPfam hit to PF00874, PRD domain, score 6.1e-13 529507010919 HMMPfam hit to PF03123, CAT RNA binding domain, score 1.1e-17 529507010920 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 529507010921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 529507010922 Coenzyme A binding pocket [chemical binding]; other site 529507010923 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 4.2e-14 529507010924 Fic/DOC family; Region: Fic; pfam02661 529507010925 HMMPfam hit to PF02661, Fic protein family, score 4.6e-27 529507010926 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 529507010927 10 probable transmembrane helices predicted for PMI2231 by TMHMM2.0 at aa 7-29, 34-56, 69-91, 95-114, 127-144, 154-176, 189-211, 221-243, 250-269 and 279-301 529507010928 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.9e-18 529507010929 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 6.1e-07 529507010930 Signal peptide predicted for PMI2231 by SignalP 2.0 HMM (Signal peptide probability 0.950) with cleavage site probability 0.732 between residues 27 and 28 529507010931 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 529507010932 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 529507010933 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 1.8e-15 529507010934 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 529507010935 MutS domain I; Region: MutS_I; pfam01624 529507010936 MutS domain II; Region: MutS_II; pfam05188 529507010937 MutS domain III; Region: MutS_III; pfam05192 529507010938 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 529507010939 Walker A/P-loop; other site 529507010940 ATP binding site [chemical binding]; other site 529507010941 Q-loop/lid; other site 529507010942 ABC transporter signature motif; other site 529507010943 Walker B; other site 529507010944 D-loop; other site 529507010945 H-loop/switch region; other site 529507010946 HMMPfam hit to PF01624, MutS domain I, score 1.4e-73 529507010947 HMMPfam hit to PF05188, MutS domain II, score 1.9e-43 529507010948 HMMPfam hit to PF05192, MutS domain III, score 1.6e-92 529507010949 HMMPfam hit to PF05190, MutS family domain IV, score 6.6e-41 529507010950 HMMPfam hit to PF00488, MutS domain V, score 7e-168 529507010951 PS00017 ATP/GTP-binding site motif A (P-loop). 529507010952 PS00486 DNA mismatch repair proteins mutS family signature. 529507010953 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 529507010954 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 529507010955 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 529507010956 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 529507010957 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 529507010958 DNA binding residues [nucleotide binding] 529507010959 HMMPfam hit to PF04545, Sigma-70, region, score 4.7e-19 529507010960 PS00716 Sigma-70 factors family signature 2. 529507010961 Predicted helix-turn-helix motif with score 1415.000, SD 4.01 at aa 284-305, sequence ETLEDVGREIGLTRERVRQIQV 529507010962 HMMPfam hit to PF04539, Sigma-70 region, score 2.1e-27 529507010963 HMMPfam hit to PF04542, Sigma-70 region, score 4.3e-26 529507010964 PS00715 Sigma-70 factors family signature 1. 529507010965 HMMPfam hit to PF00140, Sigma-70 factor, region, score 9.2e-10 529507010966 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 529507010967 Peptidase family M23; Region: Peptidase_M23; pfam01551 529507010968 HMMPfam hit to PF01551, Peptidase family M23, score 8.8e-44 529507010969 HMMPfam hit to PF01476, LysM domain, score 5e-14 529507010970 Signal peptide predicted for PMI2237 by SignalP 2.0 HMM (Signal peptide probability 0.647) with cleavage site probability 0.632 between residues 27 and 28 529507010971 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507010972 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 529507010973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507010974 S-adenosylmethionine binding site [chemical binding]; other site 529507010975 HMMPfam hit to PF01135, Protein-L-isoaspartate(D-aspartate) O-methyl, score 5e-90 529507010976 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507010977 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 529507010978 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 529507010979 HMMPfam hit to PF01975, Survival protein SurE, score 5.8e-89 529507010980 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 529507010981 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 529507010982 Permutation of conserved domain; other site 529507010983 active site 529507010984 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 529507010985 HMMPfam hit to PF01142, tRNA pseudouridine synthase D (TruD), score 1.4e-139 529507010986 PS01268 Uncharacterized protein family UPF0024 signature. 529507010987 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 529507010988 homotrimer interaction site [polypeptide binding]; other site 529507010989 zinc binding site [ion binding]; other site 529507010990 CDP-binding sites; other site 529507010991 HMMPfam hit to PF02542, YgbB family, score 1.5e-96 529507010992 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 529507010993 substrate binding site; other site 529507010994 dimer interface; other site 529507010995 HMMPfam hit to PF01128, Uncharacterized protein family UPF0007, score 2.3e-84 529507010996 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 529507010997 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 529507010998 HMMPfam hit to PF04977, Septum formation initiator, score 2e-31 529507010999 1 probable transmembrane helix predicted for PMI2243 by TMHMM2.0 at aa 5-27 529507011000 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 529507011001 ligand-binding site [chemical binding]; other site 529507011002 HMMPfam hit to PF01583, Adenylylsulphate kinase, score 3.8e-104 529507011003 PS00017 ATP/GTP-binding site motif A (P-loop). 529507011004 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 529507011005 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 529507011006 CysD dimerization site [polypeptide binding]; other site 529507011007 G1 box; other site 529507011008 putative GEF interaction site [polypeptide binding]; other site 529507011009 GTP/Mg2+ binding site [chemical binding]; other site 529507011010 Switch I region; other site 529507011011 G2 box; other site 529507011012 G3 box; other site 529507011013 Switch II region; other site 529507011014 G4 box; other site 529507011015 G5 box; other site 529507011016 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 529507011017 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 529507011018 HMMPfam hit to PF03144, Elongation factor Tu domain, score 1.7e-09 529507011019 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 1.1e-66 529507011020 PS00301 GTP-binding elongation factors signature. 529507011021 PS00017 ATP/GTP-binding site motif A (P-loop). 529507011022 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 529507011023 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 529507011024 Active Sites [active] 529507011025 HMMPfam hit to PF01507, Phosphoadenosine phosphosulfate reductase, score 1.3e-91 529507011026 siroheme synthase; Provisional; Region: cysG; PRK10637 529507011027 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 529507011028 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 529507011029 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 529507011030 active site 529507011031 SAM binding site [chemical binding]; other site 529507011032 homodimer interface [polypeptide binding]; other site 529507011033 HMMPfam hit to PF00590, Tetrapyrrole (Corrin/Porphyrin) Methylas, score 2.7e-81 529507011034 PS00839 Uroporphyrin-III C-methyltransferase signature 1. 529507011035 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 529507011036 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 529507011037 Active Sites [active] 529507011038 HMMPfam hit to PF01507, Phosphoadenosine phosphosulfate reductase, score 4.3e-76 529507011039 sulfite reductase subunit beta; Provisional; Region: PRK13504 529507011040 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 529507011041 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 529507011042 PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 529507011043 HMMPfam hit to PF03460, Nitrite/Sulfite reductase ferredoxin-lik, score 3.8e-19 529507011044 HMMPfam hit to PF01077, Nitrite and sulphite reductase 4Fe-4S do, score 2.6e-58 529507011045 HMMPfam hit to PF03460, Nitrite/Sulfite reductase ferredoxin-lik, score 6.3e-19 529507011046 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 529507011047 Flavodoxin; Region: Flavodoxin_1; pfam00258 529507011048 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 529507011049 FAD binding pocket [chemical binding]; other site 529507011050 FAD binding motif [chemical binding]; other site 529507011051 catalytic residues [active] 529507011052 NAD binding pocket [chemical binding]; other site 529507011053 phosphate binding motif [ion binding]; other site 529507011054 beta-alpha-beta structure motif; other site 529507011055 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 2.9e-40 529507011056 HMMPfam hit to PF00667, FAD binding domain, score 1.8e-53 529507011057 HMMPfam hit to PF00258, Flavodoxin, score 3.7e-33 529507011058 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 529507011059 active site 529507011060 HMMPfam hit to PF01242, 6-pyruvoyl tetrahydropterin synthase, score 3.2e-64 529507011061 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 529507011062 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 529507011063 HMMPfam hit to PF04055, Radical SAM superfamily, score 0.0025 529507011064 putative proline-specific permease; Provisional; Region: proY; PRK10580 529507011065 Signal peptide predicted for PMI2253 by SignalP 2.0 HMM (Signal peptide probability 0.985) with cleavage site probability 0.877 between residues 36 and 37 529507011066 12 probable transmembrane helices predicted for PMI2253 by TMHMM2.0 at aa 13-35, 40-62, 92-114, 124-146, 153-175, 199-221, 242-264, 279-301, 331-353, 357-379, 399-421 and 426-448 529507011067 HMMPfam hit to PF00324, Amino acid permease, score 3.2e-129 529507011068 PS00218 Amino acid permeases signature. 529507011069 methionine gamma-lyase; Provisional; Region: PRK07503 529507011070 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 529507011071 homodimer interface [polypeptide binding]; other site 529507011072 substrate-cofactor binding pocket; other site 529507011073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507011074 catalytic residue [active] 529507011075 HMMPfam hit to PF01053, Cys/Met metabolism PLP-dependent enzy, score 4.2e-218 529507011076 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 529507011077 hypothetical protein; Provisional; Region: PRK05421 529507011078 putative phosphate binding site [ion binding]; other site 529507011079 putative catalytic site [active] 529507011080 putative phosphate binding site [ion binding]; other site 529507011081 putative metal binding site [ion binding]; other site 529507011082 HMMPfam hit to PF03372, Endonuclease/Exonuclease/phosphatase fa, score 5.6e-23 529507011083 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 529507011084 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 529507011085 active site 529507011086 motif I; other site 529507011087 motif II; other site 529507011088 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 529507011089 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 529507011090 Walker A/P-loop; other site 529507011091 ATP binding site [chemical binding]; other site 529507011092 Q-loop/lid; other site 529507011093 ABC transporter signature motif; other site 529507011094 Walker B; other site 529507011095 D-loop; other site 529507011096 H-loop/switch region; other site 529507011097 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 529507011098 HMMPfam hit to PF00005, ABC transporter, score 6e-74 529507011099 PS00017 ATP/GTP-binding site motif A (P-loop). 529507011100 PS00211 ABC transporters family signature. 529507011101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507011102 dimer interface [polypeptide binding]; other site 529507011103 conserved gate region; other site 529507011104 ABC-ATPase subunit interface; other site 529507011105 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.7e-23 529507011106 5 probable transmembrane helices predicted for PMI2260 by TMHMM2.0 at aa 21-40, 55-77, 82-104, 146-168 and 181-203 529507011107 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 529507011108 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 529507011109 lipoprotein, YaeC family; Region: TIGR00363 529507011110 Signal peptide predicted for PMI2261 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.584 between residues 21 and 22 529507011111 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507011112 HMMPfam hit to PF03180, NLPA lipoprotein, score 1.4e-133 529507011113 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 529507011114 Signal peptide predicted for PMI2262 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.691 between residues 21 and 22 529507011115 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507011116 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 529507011117 homodimer interaction site [polypeptide binding]; other site 529507011118 cofactor binding site; other site 529507011119 HMMPfam hit to PF01980, Uncharacterised protein family UPF0066, score 7.2e-51 529507011120 PS01318 Uncharacterized protein family UPF0066 signature. 529507011121 prolyl-tRNA synthetase; Provisional; Region: PRK09194 529507011122 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 529507011123 dimer interface [polypeptide binding]; other site 529507011124 motif 1; other site 529507011125 active site 529507011126 motif 2; other site 529507011127 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 529507011128 putative deacylase active site [active] 529507011129 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 529507011130 active site 529507011131 motif 3; other site 529507011132 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 529507011133 anticodon binding site; other site 529507011134 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 2.5e-60 529507011135 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 529507011136 HMMPfam hit to PF04073, YbaK / prolyl-tRNA synthetases associa, score 5.3e-07 529507011137 HMMPfam hit to PF03129, Anticodon binding domain, score 1.7e-26 529507011138 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 529507011139 NlpE N-terminal domain; Region: NlpE; pfam04170 529507011140 HMMPfam hit to PF04170, Uncharacterized lipoprotein NlpE involved in, score 3.3e-23 529507011141 PS00283 Soybean trypsin inhibitor (Kunitz) protease inhibitors family signature. 529507011142 Signal peptide predicted for PMI2265 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.746 between residues 23 and 24 529507011143 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507011144 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 529507011145 HMMPfam hit to PF07073, Modulator of Rho-dependent transcription ter, score 3.7e-28 529507011146 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 529507011147 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 529507011148 Ligand Binding Site [chemical binding]; other site 529507011149 TilS substrate binding domain; Region: TilS; pfam09179 529507011150 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 529507011151 HMMPfam hit to PF01171, PP-loop family, score 2.7e-87 529507011152 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 529507011153 classical (c) SDRs; Region: SDR_c; cd05233 529507011154 NAD(P) binding site [chemical binding]; other site 529507011155 active site 529507011156 HMMPfam hit to PF00106, short chain dehydrogenase, score 1.9e-76 529507011157 PS00061 Short-chain dehydrogenases/reductases family signature. 529507011158 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 529507011159 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 529507011160 HMMPfam hit to PF03255, Acetyl co-enzyme A carboxylase carboxyltrans, score 1.5e-98 529507011161 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 529507011162 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 529507011163 putative active site [active] 529507011164 putative PHP Thumb interface [polypeptide binding]; other site 529507011165 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 529507011166 generic binding surface II; other site 529507011167 generic binding surface I; other site 529507011168 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 2.3e-13 529507011169 HMMPfam hit to PF07733, Bacterial DNA polymerase III alpha sub, score 2.5e-304 529507011170 HMMPfam hit to PF02811, PHP domain C-terminal region, score 3.5e-29 529507011171 HMMPfam hit to PF02231, PHP domain N-terminal region, score 4.6e-28 529507011172 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 529507011173 RNA/DNA hybrid binding site [nucleotide binding]; other site 529507011174 active site 529507011175 HMMPfam hit to PF01351, Ribonuclease HII, score 1.5e-85 529507011176 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 529507011177 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 529507011178 HMMPfam hit to PF02684, Lipid-A-disaccharide synthetase, score 2.9e-194 529507011179 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 529507011180 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 529507011181 active site 529507011182 PS00101 Hexapeptide-repeat containing-transferases signature. 529507011183 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 21 529507011184 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507011185 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 15 529507011186 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.42 529507011187 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 21 529507011188 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 2.7 529507011189 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1 529507011190 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.22 529507011191 PS00101 Hexapeptide-repeat containing-transferases signature. 529507011192 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.00017 529507011193 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 529507011194 HMMPfam hit to PF03061, Thioesterase superfamily, score 3.4e-21 529507011195 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 529507011196 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 529507011197 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 529507011198 trimer interface [polypeptide binding]; other site 529507011199 active site 529507011200 UDP-GlcNAc binding site [chemical binding]; other site 529507011201 lipid binding site [chemical binding]; lipid-binding site 529507011202 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 14 529507011203 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.98 529507011204 PS00101 Hexapeptide-repeat containing-transferases signature. 529507011205 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.014 529507011206 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.21 529507011207 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.092 529507011208 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.24 529507011209 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.0032 529507011210 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507011211 PS00101 Hexapeptide-repeat containing-transferases signature. 529507011212 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.017 529507011213 HMMPfam hit to PF04613, UDP-3-O-[3-hydroxymyristoyl] glucosamine N-a, score 7.4e-45 529507011214 periplasmic chaperone; Provisional; Region: PRK10780 529507011215 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 529507011216 HMMPfam hit to PF03938, Outer membrane protein (OmpH-like), score 1.4e-30 529507011217 Signal peptide predicted for PMI2276 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 47 and 48 529507011218 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 529507011219 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 529507011220 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 529507011221 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 529507011222 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 529507011223 Surface antigen; Region: Bac_surface_Ag; pfam01103 529507011224 HMMPfam hit to PF01103, Surface antigen, score 4.4e-77 529507011225 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 7.8e-08 529507011226 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 1.8e-08 529507011227 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 1e-08 529507011228 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 4.3e-08 529507011229 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 6.2e-09 529507011230 Signal peptide predicted for PMI2277 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.934 between residues 20 and 21 529507011231 zinc metallopeptidase RseP; Provisional; Region: PRK10779 529507011232 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 529507011233 active site 529507011234 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 529507011235 protein binding site [polypeptide binding]; other site 529507011236 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 529507011237 protein binding site [polypeptide binding]; other site 529507011238 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 529507011239 putative substrate binding region [chemical binding]; other site 529507011240 HMMPfam hit to PF02163, Peptidase family M50, score 3.8e-72 529507011241 4 probable transmembrane helices predicted for PMI2278 by TMHMM2.0 at aa 7-29, 97-119, 376-398 and 426-445 529507011242 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 0.0002 529507011243 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 529507011244 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 529507011245 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 529507011246 8 probable transmembrane helices predicted for PMI2279 by TMHMM2.0 at aa 7-41, 56-74, 87-106, 121-143, 150-172, 192-213, 220-237 and 266-285 529507011247 HMMPfam hit to PF01148, Cytidylyltransferase family, score 2.9e-73 529507011248 PS01315 Phosphatidate cytidylyltransferase signature. 529507011249 Signal peptide predicted for PMI2279 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.461 between residues 29 and 30 529507011250 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 529507011251 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 529507011252 catalytic residue [active] 529507011253 putative FPP diphosphate binding site; other site 529507011254 putative FPP binding hydrophobic cleft; other site 529507011255 dimer interface [polypeptide binding]; other site 529507011256 putative IPP diphosphate binding site; other site 529507011257 HMMPfam hit to PF01255, undecaprenyl diphosphate syntha, score 4.2e-133 529507011258 PS01066 Undecaprenyl pyrophosphate synthetase family signature. 529507011259 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 529507011260 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 529507011261 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 529507011262 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 529507011263 HMMPfam hit to PF02670, 1-deoxy-D-xylulose 5-phosphate reduct, score 2.3e-224 529507011264 ribosome recycling factor; Reviewed; Region: frr; PRK00083 529507011265 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 529507011266 hinge region; other site 529507011267 HMMPfam hit to PF01765, Ribosome recycling factor, score 2.6e-94 529507011268 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 529507011269 putative nucleotide binding site [chemical binding]; other site 529507011270 uridine monophosphate binding site [chemical binding]; other site 529507011271 homohexameric interface [polypeptide binding]; other site 529507011272 HMMPfam hit to PF00696, Amino acid kinase family, score 1.6e-65 529507011273 elongation factor Ts; Provisional; Region: tsf; PRK09377 529507011274 UBA/TS-N domain; Region: UBA; pfam00627 529507011275 Elongation factor TS; Region: EF_TS; pfam00889 529507011276 Elongation factor TS; Region: EF_TS; pfam00889 529507011277 HMMPfam hit to PF00889, Elongation factor TS, score 4.3e-106 529507011278 PS01127 Elongation factor Ts signature 2. 529507011279 HMMPfam hit to PF00627, UBA/TS-N domain, score 1.9e-11 529507011280 PS01126 Elongation factor Ts signature 1. 529507011281 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 529507011282 rRNA interaction site [nucleotide binding]; other site 529507011283 S8 interaction site; other site 529507011284 putative laminin-1 binding site; other site 529507011285 HMMPfam hit to PF00318, Ribosomal protein S2, score 1.3e-126 529507011286 PS00963 Ribosomal protein S2 signature 2. 529507011287 PS00962 Ribosomal protein S2 signature 1. 529507011288 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 529507011289 active site 529507011290 HMMPfam hit to PF00557, metallopeptidase family M24, score 3e-101 529507011291 PS00680 Methionine aminopeptidase subfamily 1 signature. 529507011292 PII uridylyl-transferase; Provisional; Region: PRK05007 529507011293 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 529507011294 metal binding triad; other site 529507011295 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 529507011296 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 529507011297 Zn2+ binding site [ion binding]; other site 529507011298 Mg2+ binding site [ion binding]; other site 529507011299 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 529507011300 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 529507011301 HMMPfam hit to PF01909, Nucleotidyltransferase domain, score 2.1e-07 529507011302 HMMPfam hit to PF01966, HD domain, score 4.3e-19 529507011303 HMMPfam hit to PF01842, ACT domain, score 7.6e-06 529507011304 HMMPfam hit to PF01842, ACT domain, score 3.2e-08 529507011305 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 529507011306 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 529507011307 trimer interface [polypeptide binding]; other site 529507011308 active site 529507011309 substrate binding site [chemical binding]; other site 529507011310 CoA binding site [chemical binding]; other site 529507011311 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 34 529507011312 PS00101 Hexapeptide-repeat containing-transferases signature. 529507011313 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.77 529507011314 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 3 529507011315 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.34 529507011316 hypothetical protein; Provisional; Region: PRK13677 529507011317 flavodoxin; Provisional; Region: PRK08105 529507011318 HMMPfam hit to PF00258, Flavodoxin, score 1.2e-20 529507011319 Signal peptide predicted for PMI2290 by SignalP 2.0 HMM (Signal peptide probability 0.696) with cleavage site probability 0.617 between residues 19 and 20 529507011320 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 529507011321 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 529507011322 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 529507011323 active site turn [active] 529507011324 phosphorylation site [posttranslational modification] 529507011325 10 probable transmembrane helices predicted for PMI2292 by TMHMM2.0 at aa 20-42, 49-71, 81-103, 116-138, 153-172, 248-270, 280-302, 309-331, 354-376 and 443-460 529507011326 HMMPfam hit to PF00367, phosphotransferase system, EIIB, score 1.6e-13 529507011327 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 2.9e-98 529507011328 Signal peptide predicted for PMI2292 by SignalP 2.0 HMM (Signal peptide probability 0.943) with cleavage site probability 0.717 between residues 49 and 50 529507011329 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 529507011330 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 529507011331 probable active site [active] 529507011332 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 1.9e-49 529507011333 PS01129 Rlu family of pseudouridine synthase signature. 529507011334 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 529507011335 HMMPfam hit to PF04287, Domain of unknown function, DUF446, score 1e-41 529507011336 SecY interacting protein Syd; Provisional; Region: PRK04968 529507011337 HMMPfam hit to PF07348, Syd protein, score 2.6e-86 529507011338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 529507011339 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 529507011340 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 529507011341 HMMPfam hit to PF01227, GTP cyclohydrolase I, score 5.2e-08 529507011342 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 529507011343 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 529507011344 HMMPfam hit to PF03641, Possible lysine decarboxylase, score 7.5e-54 529507011345 flap endonuclease-like protein; Provisional; Region: PRK09482 529507011346 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 529507011347 active site 529507011348 metal binding site 1 [ion binding]; metal-binding site 529507011349 putative 5' ssDNA interaction site; other site 529507011350 metal binding site 3; metal-binding site 529507011351 metal binding site 2 [ion binding]; metal-binding site 529507011352 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 529507011353 putative DNA binding site [nucleotide binding]; other site 529507011354 putative metal binding site [ion binding]; other site 529507011355 HMMPfam hit to PF02739, 5'-3' exonuclease, N-terminal resolvase-, score 3.4e-21 529507011356 HMMPfam hit to PF01367, 5'-3' exonuclease, C-terminal SAM fold, score 1.7e-18 529507011357 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 529507011358 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 529507011359 Protein of unknown function (DUF423); Region: DUF423; cl01008 529507011360 4 probable transmembrane helices predicted for PMI2300 by TMHMM2.0 at aa 5-24, 39-61, 66-88 and 98-120 529507011361 HMMPfam hit to PF04241, Protein of unknown function (DUF423), score 9.2e-31 529507011362 Signal peptide predicted for PMI2300 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.649 between residues 24 and 25 529507011363 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 529507011364 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507011365 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 529507011366 dimerization interface [polypeptide binding]; other site 529507011367 substrate binding pocket [chemical binding]; other site 529507011368 HMMPfam hit to PF03466, LysR substrate binding domain, score 4.3e-46 529507011369 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.9e-21 529507011370 PS00044 Bacterial regulatory proteins, lysR family signature. 529507011371 Predicted helix-turn-helix motif with score 1894.000, SD 5.64 at aa 21-42, sequence LSFTKAAEELFVTQAAVSHQIK 529507011372 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 529507011373 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 529507011374 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 529507011375 catalytic residue [active] 529507011376 HMMPfam hit to PF00266, Aminotransferase class-V, score 2.1e-10 529507011377 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 529507011378 Fe-S metabolism associated domain; Region: SufE; cl00951 529507011379 HMMPfam hit to PF02657, Fe-S metabolism associated domain, score 3.4e-49 529507011380 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 529507011381 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 529507011382 putative ATP binding site [chemical binding]; other site 529507011383 putative substrate interface [chemical binding]; other site 529507011384 1 probable transmembrane helix predicted for PMI2304 by TMHMM2.0 at aa 235-257 529507011385 HMMPfam hit to PF00899, ThiF family, score 9.6e-53 529507011386 murein transglycosylase A; Provisional; Region: mltA; PRK11162 529507011387 MltA specific insert domain; Region: MltA; pfam03562 529507011388 3D domain; Region: 3D; pfam06725 529507011389 HMMPfam hit to PF06725, 3D domain, score 2.3e-33 529507011390 HMMPfam hit to PF03562, MltA N-terminal domain, score 3.5e-99 529507011391 Signal peptide predicted for PMI2305 by SignalP 2.0 HMM (Signal peptide probability 0.951) with cleavage site probability 0.560 between residues 27 and 28 529507011392 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507011393 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 529507011394 AMIN domain; Region: AMIN; pfam11741 529507011395 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 529507011396 active site 529507011397 metal binding site [ion binding]; metal-binding site 529507011398 HMMPfam hit to PF01520, N-acetylmuramoyl-L-alanine amidase, score 4e-69 529507011399 1 probable transmembrane helix predicted for PMI2306 by TMHMM2.0 at aa 20-42 529507011400 Signal peptide predicted for PMI2306 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.958 between residues 31 and 32 529507011401 N-acetylglutamate synthase; Validated; Region: PRK05279 529507011402 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 529507011403 putative feedback inhibition sensing region; other site 529507011404 putative nucleotide binding site [chemical binding]; other site 529507011405 putative substrate binding site [chemical binding]; other site 529507011406 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 529507011407 Coenzyme A binding pocket [chemical binding]; other site 529507011408 HMMPfam hit to PF00696, Amino acid kinase family, score 9e-27 529507011409 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 5.5e-07 529507011410 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 529507011411 AAA domain; Region: AAA_30; pfam13604 529507011412 Family description; Region: UvrD_C_2; pfam13538 529507011413 PS00017 ATP/GTP-binding site motif A (P-loop). 529507011414 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 529507011415 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 529507011416 HMMPfam hit to PF00580, UvrD/REP helicase, score 2.1e-86 529507011417 PS00017 ATP/GTP-binding site motif A (P-loop). 529507011418 protease3; Provisional; Region: PRK15101 529507011419 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 529507011420 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 529507011421 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 529507011422 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 1.7e-14 529507011423 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 4.4e-26 529507011424 HMMPfam hit to PF00675, Insulinase (Peptidase family M16), score 2.6e-44 529507011425 PS00143 Insulinase family, zinc-binding region signature. 529507011426 Signal peptide predicted for PMI2310 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 23 and 24 529507011427 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 529507011428 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 529507011429 HMMPfam hit to PF04257, Exodeoxyribonuclease V, gamma subunit, score 0 529507011430 Signal peptide predicted for PMI2312 by SignalP 2.0 HMM (Signal peptide probability 0.893) with cleavage site probability 0.777 between residues 25 and 26 529507011431 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 529507011432 1 probable transmembrane helix predicted for PMI2313 by TMHMM2.0 at aa 13-35 529507011433 hypothetical protein; Provisional; Region: PRK10557 529507011434 1 probable transmembrane helix predicted for PMI2314 by TMHMM2.0 at aa 13-35 529507011435 hypothetical protein; Provisional; Region: PRK10506 529507011436 1 probable transmembrane helix predicted for PMI2315 by TMHMM2.0 at aa 15-37 529507011437 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 529507011438 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 529507011439 thymidylate synthase; Reviewed; Region: thyA; PRK01827 529507011440 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 529507011441 dimerization interface [polypeptide binding]; other site 529507011442 active site 529507011443 HMMPfam hit to PF00303, Thymidylate synthase, score 6.6e-130 529507011444 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 529507011445 HMMPfam hit to PF01790, Prolipoprotein diacylglyceryl transferase, score 1.4e-142 529507011446 7 probable transmembrane helices predicted for PMI2319 by TMHMM2.0 at aa 20-42, 62-84, 99-116, 123-145, 200-219, 226-243 and 258-280 529507011447 PS01311 Prolipoprotein diacylglyceryl transferase signature. 529507011448 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 529507011449 GAF domain; Region: GAF; pfam01590 529507011450 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 529507011451 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 529507011452 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 529507011453 HMMPfam hit to PF02896, PEP-utilising enzyme, TIM barrel doma, score 1.3e-124 529507011454 PS00742 PEP-utilizing enzymes signature 2. 529507011455 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile domain, score 1.4e-16 529507011456 HMMPfam hit to PF05524, PEP-utilising enzyme, N-terminal, score 3.9e-32 529507011457 HMMPfam hit to PF01590, GAF domain, score 6.9e-28 529507011458 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 529507011459 putative active site [active] 529507011460 Ap4A binding site [chemical binding]; other site 529507011461 nudix motif; other site 529507011462 putative metal binding site [ion binding]; other site 529507011463 HMMPfam hit to PF00293, NUDIX domain, score 5.5e-31 529507011464 PS00893 mutT domain signature. 529507011465 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 529507011466 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 529507011467 Signal peptide predicted for PMI2322 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.700 between residues 25 and 26 529507011468 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 0.0017 529507011469 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 529507011470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507011471 dimer interface [polypeptide binding]; other site 529507011472 conserved gate region; other site 529507011473 putative PBP binding loops; other site 529507011474 ABC-ATPase subunit interface; other site 529507011475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507011476 dimer interface [polypeptide binding]; other site 529507011477 conserved gate region; other site 529507011478 putative PBP binding loops; other site 529507011479 ABC-ATPase subunit interface; other site 529507011480 Signal peptide predicted for PMI2323 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.380 between residues 24 and 25 529507011481 12 probable transmembrane helices predicted for PMI2323 by TMHMM2.0 at aa 5-27, 47-69, 82-104, 119-141, 193-215, 235-252, 285-302, 322-344, 365-387, 397-416, 458-480 and 500-517 529507011482 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.7e-06 529507011483 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 0.0021 529507011484 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 529507011485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507011486 Walker A/P-loop; other site 529507011487 ATP binding site [chemical binding]; other site 529507011488 Q-loop/lid; other site 529507011489 ABC transporter signature motif; other site 529507011490 Walker B; other site 529507011491 D-loop; other site 529507011492 H-loop/switch region; other site 529507011493 HMMPfam hit to PF00005, ABC transporter, score 7.7e-67 529507011494 PS00017 ATP/GTP-binding site motif A (P-loop). 529507011495 PS00211 ABC transporters family signature. 529507011496 Helix-turn-helix domain; Region: HTH_17; pfam12728 529507011497 Predicted helix-turn-helix motif with score 1557.000, SD 4.49 at aa 121-142, sequence LTTQEAADILNMSRPTFVKLLD 529507011498 PIN domain; Region: PIN_3; pfam13470 529507011499 DNA polymerase II; Reviewed; Region: PRK05762 529507011500 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 529507011501 active site 529507011502 catalytic site [active] 529507011503 substrate binding site [chemical binding]; other site 529507011504 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 529507011505 active site 529507011506 metal-binding site 529507011507 HMMPfam hit to PF03104, DNA polymerase family B, exonuclease do, score 6.5e-26 529507011508 HMMPfam hit to PF00136, DNA polymerase family B, score 5e-65 529507011509 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507011510 PS00116 DNA polymerase family B signature. 529507011511 ATP-dependent helicase HepA; Validated; Region: PRK04914 529507011512 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 529507011513 ATP binding site [chemical binding]; other site 529507011514 putative Mg++ binding site [ion binding]; other site 529507011515 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 529507011516 nucleotide binding region [chemical binding]; other site 529507011517 ATP-binding site [chemical binding]; other site 529507011518 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 1.4e-06 529507011519 HMMPfam hit to PF00176, SNF2 family N-terminal domain, score 1.4e-59 529507011520 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 7.2e-18 529507011521 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 529507011522 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 529507011523 active site 529507011524 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 1.6e-59 529507011525 PS01129 Rlu family of pseudouridine synthase signature. 529507011526 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 529507011527 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 529507011528 putative metal binding site [ion binding]; other site 529507011529 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 529507011530 HMMPfam hit to PF00226, DnaJ domain, score 2.4e-12 529507011531 1 probable transmembrane helix predicted for PMI2330 by TMHMM2.0 at aa 7-29 529507011532 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 529507011533 OstA-like protein; Region: OstA; pfam03968 529507011534 Organic solvent tolerance protein; Region: OstA_C; pfam04453 529507011535 Signal peptide predicted for PMI2331 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 24 and 25 529507011536 HMMPfam hit to PF04453, Organic solvent tolerance protein, score 5.8e-116 529507011537 Predicted helix-turn-helix motif with score 1017.000, SD 2.65 at aa 568-589, sequence FYDSELVERFNISVGQIYFFER 529507011538 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 529507011539 SurA N-terminal domain; Region: SurA_N; pfam09312 529507011540 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 529507011541 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 529507011542 Signal peptide predicted for PMI2332 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.985 between residues 25 and 26 529507011543 1 probable transmembrane helix predicted for PMI2332 by TMHMM2.0 at aa 20-42 529507011544 HMMPfam hit to PF00639, PPIC-type PPIASE domain, score 1.7e-31 529507011545 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 529507011546 HMMPfam hit to PF00639, PPIC-type PPIASE domain, score 1.4e-41 529507011547 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 529507011548 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 529507011549 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 529507011550 HMMPfam hit to PF04166, Pyridoxal phosphate biosynthetic protein Pdx, score 7e-167 529507011551 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 529507011552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507011553 S-adenosylmethionine binding site [chemical binding]; other site 529507011554 HMMPfam hit to PF00398, Ribosomal RNA adenine dimethylase, score 6.2e-88 529507011555 PS01131 Ribosomal RNA adenine dimethylases signature. 529507011556 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 529507011557 HMMPfam hit to PF04379, Protein of unknown function (DUF525), score 1.4e-68 529507011558 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 529507011559 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 529507011560 active site 529507011561 metal binding site [ion binding]; metal-binding site 529507011562 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 1.4e-18 529507011563 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 529507011564 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 529507011565 folate binding site [chemical binding]; other site 529507011566 NADP+ binding site [chemical binding]; other site 529507011567 HMMPfam hit to PF00186, Dihydrofolate reductase, score 2e-48 529507011568 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 529507011569 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 529507011570 Probable transposase; Region: OrfB_IS605; pfam01385 529507011571 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 529507011572 HMMPfam hit to PF07282, transposase DNA-binding domai, score 2.5e-33 529507011573 HMMPfam hit to PF01385, Probable transposase, score 1.1e-132 529507011574 Transposase IS200 like; Region: Y1_Tnp; pfam01797 529507011575 1 probable transmembrane helix predicted for PMI2339 by TMHMM2.0 at aa 7-24 529507011576 HMMPfam hit to PF01797, Transposase IS200 like, score 2.7e-28 529507011577 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 529507011578 catalytic triad [active] 529507011579 putative active site [active] 529507011580 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 529507011581 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 529507011582 Autotransporter beta-domain; Region: Autotransporter; pfam03797 529507011583 HMMPfam hit to PF03797, Autotransporter beta-domain, score 3e-11 529507011584 PS00017 ATP/GTP-binding site motif A (P-loop). 529507011585 HMMPfam hit to PF00082, Subtilase family, score 3.1e-28 529507011586 PS00138 Serine proteases, subtilase family, serine active site. 529507011587 PS00137 Serine proteases, subtilase family, histidine active site. 529507011588 Signal peptide predicted for PMI2341 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 40 and 41 529507011589 1 probable transmembrane helix predicted for PMI2341 by TMHMM2.0 at aa 21-40 529507011590 FtsI repressor; Provisional; Region: PRK10883 529507011591 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 529507011592 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 529507011593 HMMPfam hit to PF07731, Multicopper oxidase, score 2.2e-06 529507011594 HMMPfam hit to PF07732, Multicopper oxidase, score 4.1e-39 529507011595 Signal peptide predicted for PMI2342 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.964 between residues 27 and 28 529507011596 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 529507011597 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 529507011598 putative acyl-acceptor binding pocket; other site 529507011599 HMMPfam hit to PF01553, Acyltransferase, score 8e-47 529507011600 1 probable transmembrane helix predicted for PMI2343 by TMHMM2.0 at aa 2-24 529507011601 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 529507011602 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 529507011603 CAP-like domain; other site 529507011604 active site 529507011605 primary dimer interface [polypeptide binding]; other site 529507011606 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 3.8e-05 529507011607 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 0.0021 529507011608 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 0.028 529507011609 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 0.24 529507011610 HMMPfam hit to PF00521, DNA gyrase/topoisomerase IV, subunit A, score 3e-247 529507011611 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 529507011612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 529507011613 ATP binding site [chemical binding]; other site 529507011614 Mg2+ binding site [ion binding]; other site 529507011615 G-X-G motif; other site 529507011616 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 529507011617 anchoring element; other site 529507011618 dimer interface [polypeptide binding]; other site 529507011619 ATP binding site [chemical binding]; other site 529507011620 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 529507011621 active site 529507011622 metal binding site [ion binding]; metal-binding site 529507011623 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 529507011624 HMMPfam hit to PF00986, DNA gyrase B subunit, carboxyl terminus, score 1.7e-29 529507011625 PS00177 DNA topoisomerase II signature. 529507011626 HMMPfam hit to PF00204, DNA gyrase B, score 8.1e-55 529507011627 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and H, score 6.7e-28 529507011628 esterase YqiA; Provisional; Region: PRK11071 529507011629 HMMPfam hit to PF05728, Uncharacterised protein family (UPF0227), score 2.3e-90 529507011630 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 529507011631 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 529507011632 active site 529507011633 metal binding site [ion binding]; metal-binding site 529507011634 hexamer interface [polypeptide binding]; other site 529507011635 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 3.1e-17 529507011636 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 529507011637 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 529507011638 dimer interface [polypeptide binding]; other site 529507011639 ADP-ribose binding site [chemical binding]; other site 529507011640 active site 529507011641 nudix motif; other site 529507011642 metal binding site [ion binding]; metal-binding site 529507011643 HMMPfam hit to PF00293, NUDIX domain, score 1.2e-20 529507011644 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 529507011645 Signal peptide predicted for PMI2349 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.989 between residues 22 and 23 529507011646 HMMPfam hit to PF02321, Outer membrane efflux protein, score 7.1e-37 529507011647 HMMPfam hit to PF02321, Outer membrane efflux protein, score 3.8e-49 529507011648 hypothetical protein; Provisional; Region: PRK11653 529507011649 Signal peptide predicted for PMI2350 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.560 between residues 38 and 39 529507011650 1 probable transmembrane helix predicted for PMI2350 by TMHMM2.0 at aa 21-38 529507011651 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507011652 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 529507011653 HMMPfam hit to PF03738, Glutathionylspermidine synthase, score 7.5e-229 529507011654 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 529507011655 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 529507011656 putative active site [active] 529507011657 metal binding site [ion binding]; metal-binding site 529507011658 HMMPfam hit to PF02900, Catalytic LigB subunit of aromatic ring-open, score 2.8e-63 529507011659 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 529507011660 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 529507011661 HMMPfam hit to PF00926, 3,4-dihydroxy-2-butanone 4-phosphate sy, score 3.3e-129 529507011662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 529507011663 HMMPfam hit to PF04380, Protein of unknown function (DUF526), score 2.2e-38 529507011664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507011665 AAA domain; Region: AAA_21; pfam13304 529507011666 Walker A/P-loop; other site 529507011667 ATP binding site [chemical binding]; other site 529507011668 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507011669 Walker B; other site 529507011670 D-loop; other site 529507011671 H-loop/switch region; other site 529507011672 PS00017 ATP/GTP-binding site motif A (P-loop). 529507011673 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 529507011674 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 529507011675 putative active site [active] 529507011676 putative NTP binding site [chemical binding]; other site 529507011677 putative nucleic acid binding site [nucleotide binding]; other site 529507011678 HMMPfam hit to PF00078, Reverse transcriptase (RNA-dependent DNA pol, score 1.3e-07 529507011679 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 529507011680 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 529507011681 putative ribose interaction site [chemical binding]; other site 529507011682 putative ADP binding site [chemical binding]; other site 529507011683 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 529507011684 active site 529507011685 nucleotide binding site [chemical binding]; other site 529507011686 HIGH motif; other site 529507011687 KMSKS motif; other site 529507011688 HMMPfam hit to PF01467, Cytidylyltransferase, score 1.2e-25 529507011689 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 4.8e-56 529507011690 PS00583 pfkB family of carbohydrate kinases signature 1. 529507011691 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 529507011692 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 529507011693 metal binding triad; other site 529507011694 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 529507011695 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 529507011696 metal binding triad; other site 529507011697 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 529507011698 HMMPfam hit to PF03710, Glutamate-ammonia ligase adenylyltransferase, score 1.8e-123 529507011699 HMMPfam hit to PF03710, Glutamate-ammonia ligase adenylyltransferase, score 1.3e-121 529507011700 Uncharacterized conserved protein [Function unknown]; Region: COG3025 529507011701 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 529507011702 putative active site [active] 529507011703 putative metal binding residues [ion binding]; other site 529507011704 signature motif; other site 529507011705 putative triphosphate binding site [ion binding]; other site 529507011706 HMMPfam hit to PF01928, CYTH domain, score 3.1e-42 529507011707 Bacterial SH3 domain homologues; Region: SH3b; smart00287 529507011708 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 529507011709 Signal peptide predicted for PMI2361 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 529507011710 1 probable transmembrane helix predicted for PMI2361 by TMHMM2.0 at aa 218-240 529507011711 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 529507011712 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 529507011713 active site 529507011714 NTP binding site [chemical binding]; other site 529507011715 metal binding triad [ion binding]; metal-binding site 529507011716 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 529507011717 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 529507011718 Zn2+ binding site [ion binding]; other site 529507011719 Mg2+ binding site [ion binding]; other site 529507011720 HMMPfam hit to PF01743, Poly A polymerase family, score 7.1e-62 529507011721 HMMPfam hit to PF01966, HD domain, score 8.4e-13 529507011722 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 529507011723 homooctamer interface [polypeptide binding]; other site 529507011724 active site 529507011725 HMMPfam hit to PF02152, Dihydroneopterin aldolase, score 6.3e-45 529507011726 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 529507011727 Signal peptide predicted for PMI2364 by SignalP 2.0 HMM (Signal peptide probability 0.750) with cleavage site probability 0.673 between residues 20 and 21 529507011728 5 probable transmembrane helices predicted for PMI2364 by TMHMM2.0 at aa 5-27, 53-75, 80-102, 109-131 and 136-158 529507011729 HMMPfam hit to PF02660, Domain of unknown function DUF, score 9.1e-100 529507011730 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 529507011731 Prephenate dehydratase; Region: PDT; pfam00800 529507011732 Cupin domain; Region: Cupin_2; pfam07883 529507011733 HMMPfam hit to PF07883, Cupin domain, score 5.8e-14 529507011734 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 529507011735 HMMPfam hit to PF01474, Class-II DAHP synthetase family, score 8.9e-184 529507011736 UGMP family protein; Validated; Region: PRK09604 529507011737 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 529507011738 HMMPfam hit to PF00814, Glycoprotease family, score 9.9e-25 529507011739 PS01016 Glycoprotease family signature. 529507011740 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 529507011741 HMMPfam hit to PF01165, Ribosomal protein S21, score 2.5e-35 529507011742 PS01181 Ribosomal protein S21 signature. 529507011743 DNA primase; Validated; Region: dnaG; PRK05667 529507011744 CHC2 zinc finger; Region: zf-CHC2; pfam01807 529507011745 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 529507011746 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 529507011747 active site 529507011748 metal binding site [ion binding]; metal-binding site 529507011749 interdomain interaction site; other site 529507011750 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 529507011751 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 529507011752 HMMPfam hit to PF01807, CHC2 zinc finger, score 3.5e-63 529507011753 HMMPfam hit to PF01751, Toprim domain, score 6.5e-24 529507011754 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 529507011755 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 529507011756 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 529507011757 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 529507011758 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 529507011759 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 529507011760 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 529507011761 DNA binding residues [nucleotide binding] 529507011762 HMMPfam hit to PF03979, Sigma-70 factor, region, score 3.9e-43 529507011763 HMMPfam hit to PF00140, Sigma-70 factor, region, score 2.5e-15 529507011764 HMMPfam hit to PF04546, Sigma-70, non-essential region, score 5.4e-114 529507011765 HMMPfam hit to PF04542, Sigma-70 region, score 1.8e-28 529507011766 PS00715 Sigma-70 factors family signature 1. 529507011767 HMMPfam hit to PF04539, Sigma-70 region, score 5.5e-41 529507011768 HMMPfam hit to PF04545, Sigma-70, region, score 2.1e-21 529507011769 Predicted helix-turn-helix motif with score 1917.000, SD 5.72 at aa 583-604, sequence HTLEEVGKQFDVTRERIRQIEA 529507011770 PS00716 Sigma-70 factors family signature 2. 529507011771 1 probable transmembrane helix predicted for PMI2373 by TMHMM2.0 at aa 4-26 529507011772 Predicted helix-turn-helix motif with score 983.000, SD 2.53 at aa 200-221, sequence GSQIFDNEVYSVTEEQLRQWLD 529507011773 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 529507011774 HMMPfam hit to PF05249, Uncharacterised protein family (UPF0187), score 6.7e-127 529507011775 3 probable transmembrane helices predicted for PMI2374 by TMHMM2.0 at aa 20-42, 47-69 and 219-241 529507011776 1 probable transmembrane helix predicted for PMI2375 by TMHMM2.0 at aa 25-47 529507011777 Signal peptide predicted for PMI2375 by SignalP 2.0 HMM (Signal peptide probability 0.793) with cleavage site probability 0.283 between residues 44 and 45 529507011778 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 529507011779 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 529507011780 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 529507011781 HMMPfam hit to PF02322, Cytochrome oxidase subunit II, score 1.4e-138 529507011782 8 probable transmembrane helices predicted for PMI2376 by TMHMM2.0 at aa 5-23, 74-96, 117-139, 159-181, 194-216, 231-253, 260-282 and 302-324 529507011783 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 529507011784 HMMPfam hit to PF01654, Bacterial Cytochrome Ubiquinol Oxidase, score 3.6e-213 529507011785 9 probable transmembrane helices predicted for PMI2377 by TMHMM2.0 at aa 15-37, 56-78, 98-120, 127-149, 186-208, 221-238, 323-345, 357-379 and 410-432 529507011786 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 529507011787 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 529507011788 putative molybdopterin cofactor binding site [chemical binding]; other site 529507011789 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 529507011790 putative molybdopterin cofactor binding site; other site 529507011791 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 4.7e-09 529507011792 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 6.8e-08 529507011793 Transcriptional regulator [Transcription]; Region: LysR; COG0583 529507011794 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507011795 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 529507011796 dimerization interface [polypeptide binding]; other site 529507011797 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.1e-20 529507011798 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.1e-05 529507011799 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 529507011800 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 529507011801 dimer interface [polypeptide binding]; other site 529507011802 putative CheW interface [polypeptide binding]; other site 529507011803 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 3.9e-64 529507011804 HMMPfam hit to PF00672, HAMP domain, score 4.6e-05 529507011805 2 probable transmembrane helices predicted for PMI2380 by TMHMM2.0 at aa 15-34 and 182-204 529507011806 Signal peptide predicted for PMI2380 by SignalP 2.0 HMM (Signal peptide probability 0.622) with cleavage site probability 0.237 between residues 29 and 30 529507011807 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 529507011808 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 529507011809 dimer interface [polypeptide binding]; other site 529507011810 putative CheW interface [polypeptide binding]; other site 529507011811 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 4e-63 529507011812 HMMPfam hit to PF00672, HAMP domain, score 2.4e-05 529507011813 2 probable transmembrane helices predicted for PMI2381 by TMHMM2.0 at aa 26-47 and 195-217 529507011814 Signal peptide predicted for PMI2381 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.364 between residues 25 and 26 529507011815 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 529507011816 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 529507011817 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 529507011818 putative metal binding site [ion binding]; other site 529507011819 HMMPfam hit to PF02342, Bacterial stress protein, score 2.1e-70 529507011820 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 529507011821 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 529507011822 putative metal binding site [ion binding]; other site 529507011823 HMMPfam hit to PF02342, Bacterial stress protein, score 3.4e-70 529507011824 Integral membrane protein TerC family; Region: TerC; cl10468 529507011825 9 probable transmembrane helices predicted for PMI2385 by TMHMM2.0 at aa 10-29, 42-61, 81-100, 107-129, 133-155, 215-237, 252-272, 285-302 and 312-334 529507011826 HMMPfam hit to PF03741, Integral membrane protein TerC family, score 8.8e-86 529507011827 tellurite resistance protein terB; Region: terB; cd07176 529507011828 putative metal binding site [ion binding]; other site 529507011829 HMMPfam hit to PF05099, Tellurite resistance protein TerB, score 3.3e-83 529507011830 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 529507011831 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 529507011832 putative metal binding site [ion binding]; other site 529507011833 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 529507011834 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 529507011835 putative metal binding site [ion binding]; other site 529507011836 HMMPfam hit to PF02342, Bacterial stress protein, score 1.1e-15 529507011837 HMMPfam hit to PF02342, Bacterial stress protein, score 3.1e-28 529507011838 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 529507011839 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 529507011840 putative metal binding site [ion binding]; other site 529507011841 HMMPfam hit to PF02342, Bacterial stress protein, score 1.3e-48 529507011842 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 529507011843 active site 529507011844 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 529507011845 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 529507011846 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 529507011847 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 529507011848 PS00017 ATP/GTP-binding site motif A (P-loop). 529507011849 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 529507011850 HMMPfam hit to PF03544, Gram-negative bacterial tonB protein, score 9.8e-09 529507011851 Signal peptide predicted for PMI2394 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 24 and 25 529507011852 1 probable transmembrane helix predicted for PMI2394 by TMHMM2.0 at aa 5-24 529507011853 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 529507011854 nudix motif; other site 529507011855 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 529507011856 HMMPfam hit to PF00293, NUDIX domain, score 3.5e-13 529507011857 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 529507011858 NADH kinase; Region: PLN02929 529507011859 tetracycline repressor protein TetR; Provisional; Region: PRK13756 529507011860 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 529507011861 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 529507011862 HMMPfam hit to PF02909, Tetracyclin repressor, C-terminal all-alpha, score 2.5e-66 529507011863 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 1.4e-14 529507011864 PS01081 Bacterial regulatory proteins, tetR family signature. 529507011865 Predicted helix-turn-helix motif with score 2218.000, SD 6.74 at aa 25-46, sequence LTTRKLAQKLGVEQPTLYWHVK 529507011866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507011867 Major Facilitator Superfamily; Region: MFS_1; pfam07690 529507011868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507011869 HMMPfam hit to PF00083, Sugar (and other) transporter, score 0.00012 529507011870 11 probable transmembrane helices predicted for PMI2399 by TMHMM2.0 at aa 7-29, 39-61, 73-95, 99-118, 130-152, 157-179, 211-233, 248-270, 291-313, 338-360 and 367-386 529507011871 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 7.8e-55 529507011872 PS00216 Sugar transport proteins signature 1. 529507011873 Phage holin family 2; Region: Phage_holin_2; pfam04550 529507011874 HMMPfam hit to PF04550, Phage holin family, score 7.3e-24 529507011875 3 probable transmembrane helices predicted for PMI2400 by TMHMM2.0 at aa 25-44, 51-73 and 78-100 529507011876 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 529507011877 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 529507011878 Dak1 domain; Region: Dak1; pfam02733 529507011879 HMMPfam hit to PF02733, Dak1 domain, score 3.8e-180 529507011880 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507011881 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 529507011882 HMMPfam hit to PF02734, DAK2 domain, score 4.4e-79 529507011883 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 529507011884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 529507011885 active site 529507011886 active pocket/dimerization site; other site 529507011887 phosphorylation site [posttranslational modification] 529507011888 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 529507011889 dimerization domain swap beta strand [polypeptide binding]; other site 529507011890 regulatory protein interface [polypeptide binding]; other site 529507011891 active site 529507011892 regulatory phosphorylation site [posttranslational modification]; other site 529507011893 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 529507011894 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 529507011895 HMMPfam hit to PF03610, PTS system fructose IIA component, score 2e-32 529507011896 HMMPfam hit to PF00381, PTS HPr component phosphorylation sit, score 2e-12 529507011897 HMMPfam hit to PF05524, PEP-utilising enzyme, N-terminal, score 2.2e-20 529507011898 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile domain, score 4.6e-07 529507011899 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 529507011900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507011901 active site 529507011902 phosphorylation site [posttranslational modification] 529507011903 intermolecular recognition site; other site 529507011904 dimerization interface [polypeptide binding]; other site 529507011905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 529507011906 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 529507011907 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 1.7e-12 529507011908 PS00688 Sigma-54 interaction domain C-terminal part signature. 529507011909 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 7.5e-14 529507011910 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.6e-33 529507011911 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 529507011912 HAMP domain; Region: HAMP; pfam00672 529507011913 dimerization interface [polypeptide binding]; other site 529507011914 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 529507011915 dimer interface [polypeptide binding]; other site 529507011916 phosphorylation site [posttranslational modification] 529507011917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 529507011918 ATP binding site [chemical binding]; other site 529507011919 Mg2+ binding site [ion binding]; other site 529507011920 G-X-G motif; other site 529507011921 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 4.3e-25 529507011922 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 0.00076 529507011923 HMMPfam hit to PF00672, HAMP domain, score 1.8e-06 529507011924 2 probable transmembrane helices predicted for PMI2406 by TMHMM2.0 at aa 15-37 and 325-347 529507011925 Signal peptide predicted for PMI2406 by SignalP 2.0 HMM (Signal peptide probability 0.962) with cleavage site probability 0.792 between residues 43 and 44 529507011926 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 529507011927 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 529507011928 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 9.4e-05 529507011929 Signal peptide predicted for PMI2407 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 23 and 24 529507011930 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 529507011931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507011932 putative substrate translocation pore; other site 529507011933 10 probable transmembrane helices predicted for PMI2408 by TMHMM2.0 at aa 28-50, 60-82, 103-125, 181-203, 248-267, 282-304, 317-336, 346-368, 375-397 and 417-439 529507011934 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 6.5e-44 529507011935 pyruvate kinase; Provisional; Region: PRK05826 529507011936 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 529507011937 domain interfaces; other site 529507011938 active site 529507011939 HMMPfam hit to PF00224, Pyruvate kinase, barrel domain, score 1.8e-173 529507011940 HMMPfam hit to PF02887, Pyruvate kinase, alpha/beta domain, score 6e-05 529507011941 hypothetical protein; Provisional; Region: PRK11019 529507011942 HMMPfam hit to PF01258, Prokaryotic dksA/traR C4-type zinc finge, score 2e-18 529507011943 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 529507011944 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 529507011945 catalytic residue [active] 529507011946 HMMPfam hit to PF00282, Pyridoxal-dependent decarboxylase conse, score 8e-11 529507011947 Predicted helix-turn-helix motif with score 1071.000, SD 2.83 at aa 153-174, sequence VTIKKVAKLVGYDPEVASGVFT 529507011948 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 529507011949 Citrate transporter; Region: CitMHS; pfam03600 529507011950 10 probable transmembrane helices predicted for PMI2412 by TMHMM2.0 at aa 20-39, 46-68, 78-95, 108-130, 134-151, 158-180, 200-219, 264-295, 310-332 and 438-457 529507011951 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 529507011952 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 529507011953 HMMPfam hit to PF01048, Phosphorylase family, score 9.1e-114 529507011954 PS01232 Purine and other phosphorylases family 1 signature. 529507011955 phosphopentomutase; Provisional; Region: PRK05362 529507011956 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 529507011957 HMMPfam hit to PF01676, Metalloenzyme superfamily, score 5.9e-47 529507011958 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 529507011959 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 529507011960 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 529507011961 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 529507011962 HMMPfam hit to PF07831, Pyrimidine nucleoside phosphorylase C, score 5.9e-30 529507011963 HMMPfam hit to PF00591, Glycosyl transferase family, a/b doma, score 2e-78 529507011964 PS00647 Thymidine and pyrimidine-nucleoside phosphorylases signature. 529507011965 HMMPfam hit to PF02885, Glycosyl transferase family, helical, score 2e-21 529507011966 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 529507011967 intersubunit interface [polypeptide binding]; other site 529507011968 active site 529507011969 catalytic residue [active] 529507011970 HMMPfam hit to PF01791, Deoxyribose-phosphate aldolase, score 2e-79 529507011971 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 529507011972 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 529507011973 Nucleoside recognition; Region: Gate; pfam07670 529507011974 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 529507011975 8 probable transmembrane helices predicted for PMI2418 by TMHMM2.0 at aa 5-27, 32-54, 102-124, 179-201, 275-297, 304-326, 371-393 and 414-436 529507011976 HMMPfam hit to PF07662, Na+ dependent nucleoside transporter C, score 2.1e-108 529507011977 HMMPfam hit to PF07670, Nucleoside recognition, score 4.5e-18 529507011978 HMMPfam hit to PF01773, Na+ dependent nucleoside transporter N, score 6.2e-30 529507011979 Signal peptide predicted for PMI2418 by SignalP 2.0 HMM (Signal peptide probability 0.816) with cleavage site probability 0.639 between residues 26 and 27 529507011980 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 529507011981 active site 529507011982 HMMPfam hit to PF01026, TatD related DNase, score 5.5e-94 529507011983 PS01091 Uncharacterized protein family UPF0006 signature 3. 529507011984 PS01090 Uncharacterized protein family UPF0006 signature 2. 529507011985 PS01137 Uncharacterized protein family UPF0006 signature 1. 529507011986 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 529507011987 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 529507011988 active site 529507011989 nucleophile elbow; other site 529507011990 HMMPfam hit to PF01734, Patatin-like phospholipase, score 1.2e-17 529507011991 periplasmic protein; Provisional; Region: PRK10568 529507011992 HMMPfam hit to PF04972, phospholipid-binding domain, score 2.8e-07 529507011993 Signal peptide predicted for PMI2421 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 27 and 28 529507011994 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 529507011995 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 529507011996 G1 box; other site 529507011997 putative GEF interaction site [polypeptide binding]; other site 529507011998 GTP/Mg2+ binding site [chemical binding]; other site 529507011999 Switch I region; other site 529507012000 G2 box; other site 529507012001 G3 box; other site 529507012002 Switch II region; other site 529507012003 G4 box; other site 529507012004 G5 box; other site 529507012005 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 529507012006 HMMPfam hit to PF03144, Elongation factor Tu domain, score 1.6e-09 529507012007 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 1.5e-59 529507012008 PS00301 GTP-binding elongation factors signature. 529507012009 Conjugative-transposon-like mobile genetic element (high GC region). 529507012010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507012011 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 529507012012 non-specific DNA binding site [nucleotide binding]; other site 529507012013 salt bridge; other site 529507012014 sequence-specific DNA binding site [nucleotide binding]; other site 529507012015 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 529507012016 Catalytic site [active] 529507012017 HMMPfam hit to PF00717, Peptidase S24-like, score 1.9e-19 529507012018 HMMPfam hit to PF01381, Helix-turn-helix, score 2.6e-08 529507012019 Predicted helix-turn-helix motif with score 1944.000, SD 5.81 at aa 17-38, sequence VTQSELARRIGIKQQSISQICS 529507012020 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 529507012021 Predicted helix-turn-helix motif with score 1310.000, SD 3.65 at aa 19-40, sequence GGQSALARAINSKQQNVWFWLN 529507012022 PS00017 ATP/GTP-binding site motif A (P-loop). 529507012023 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 529507012024 N-acetyl-D-glucosamine binding site [chemical binding]; other site 529507012025 catalytic residue [active] 529507012026 Signal peptide predicted for PMI2427 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.797 between residues 23 and 24 529507012027 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 1.1e-06 529507012028 Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012 529507012029 Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036 529507012030 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 529507012031 Signal peptide predicted for PMI2430 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.439 between residues 39 and 40 529507012032 4 probable transmembrane helices predicted for PMI2430 by TMHMM2.0 at aa 20-39, 49-67, 74-91 and 95-114 529507012033 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 529507012034 HMMPfam hit to PF07916, TraG-like protein, N-terminal region, score 1.2e-229 529507012035 2 probable transmembrane helices predicted for PMI2431 by TMHMM2.0 at aa 333-355 and 362-384 529507012036 Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122 529507012037 HMMPfam hit to PF06122, TraH protein, score 5.2e-240 529507012038 Signal peptide predicted for PMI2432 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.877 between residues 22 and 23 529507012039 TraF-like protein; Region: TraF-like; TIGR02740 529507012040 F plasmid transfer operon protein; Region: TraF; pfam13728 529507012041 Signal peptide predicted for PMI2433 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.999 between residues 29 and 30 529507012042 1 probable transmembrane helix predicted for PMI2433 by TMHMM2.0 at aa 5-27 529507012043 Part of AAA domain; Region: AAA_19; pfam13245 529507012044 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 529507012045 Family description; Region: UvrD_C_2; pfam13538 529507012046 HMMPfam hit to PF00580, UvrD/REP helicase, score 5.8e-11 529507012047 PS00017 ATP/GTP-binding site motif A (P-loop). 529507012048 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 529507012049 AAA domain; Region: AAA_21; pfam13304 529507012050 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507012051 ABC transporter signature motif; other site 529507012052 Walker B; other site 529507012053 D-loop; other site 529507012054 H-loop/switch region; other site 529507012055 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 529507012056 putative active site [active] 529507012057 putative metal-binding site [ion binding]; other site 529507012058 PS00017 ATP/GTP-binding site motif A (P-loop). 529507012059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 529507012060 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; pfam08273 529507012061 Toprim domain; Region: Toprim_3; pfam13362 529507012062 hypothetical protein; Reviewed; Region: PRK00024 529507012063 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 529507012064 MPN+ (JAMM) motif; other site 529507012065 Zinc-binding site [ion binding]; other site 529507012066 HMMPfam hit to PF04002, RadC, DNA repair protein, score 2.4e-67 529507012067 PS01302 DNA repair protein radC family signature. 529507012068 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 529507012069 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 529507012070 metal ion-dependent adhesion site (MIDAS); other site 529507012071 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 529507012072 WGR domain; Region: WGR; cl01581 529507012073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 529507012074 Walker A motif; other site 529507012075 ATP binding site [chemical binding]; other site 529507012076 Walker B motif; other site 529507012077 arginine finger; other site 529507012078 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 529507012079 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 4.8e-15 529507012080 PS00017 ATP/GTP-binding site motif A (P-loop). 529507012081 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 529507012082 1 probable transmembrane helix predicted for PMI2447 by TMHMM2.0 at aa 7-24 529507012083 Signal peptide predicted for PMI2447 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.696 between residues 23 and 24 529507012084 RecT family; Region: RecT; cl04285 529507012085 HMMPfam hit to PF03837, RecT family, score 3.3e-15 529507012086 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 529507012087 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 529507012088 dimer interface [polypeptide binding]; other site 529507012089 ssDNA binding site [nucleotide binding]; other site 529507012090 tetramer (dimer of dimers) interface [polypeptide binding]; other site 529507012091 HMMPfam hit to PF00436, Single-strand binding protein family, score 1.2e-12 529507012092 1 probable transmembrane helix predicted for PMI2450 by TMHMM2.0 at aa 4-26 529507012093 Endonuclease I; Region: Endonuclease_1; pfam04231 529507012094 Signal peptide predicted for PMI2452 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 21 and 22 529507012095 1 probable transmembrane helix predicted for PMI2452 by TMHMM2.0 at aa 5-27 529507012096 HMMPfam hit to PF04231, Endonuclease I, score 3.2e-87 529507012097 PS00041 Bacterial regulatory proteins, araC family signature. 529507012098 Dynamin family; Region: Dynamin_N; pfam00350 529507012099 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 529507012100 G1 box; other site 529507012101 GTP/Mg2+ binding site [chemical binding]; other site 529507012102 G2 box; other site 529507012103 Switch I region; other site 529507012104 3 probable transmembrane helices predicted for PMI2454 by TMHMM2.0 at aa 588-610, 617-639 and 643-665 529507012105 PS00017 ATP/GTP-binding site motif A (P-loop). 529507012106 2 probable transmembrane helices predicted for PMI2455 by TMHMM2.0 at aa 13-35 and 55-77 529507012107 conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14876 529507012108 conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14876 529507012109 HMMPfam hit to PF06986, Mating pair stabilisation protein TraN, score 1.6e-19 529507012110 HMMPfam hit to PF06986, Mating pair stabilisation protein TraN, score 4.5e-17 529507012111 Signal peptide predicted for PMI2456 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.779 between residues 27 and 28 529507012112 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507012113 TraU protein; Region: TraU; pfam06834 529507012114 HMMPfam hit to PF06834, TraU protein, score 4.6e-228 529507012115 Signal peptide predicted for PMI2457 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.846 between residues 28 and 29 529507012116 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 529507012117 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 529507012118 Signal peptide predicted for PMI2458 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 23 and 24 529507012119 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 529507012120 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 529507012121 Predicted helix-turn-helix motif with score 1108.000, SD 2.96 at aa 112-133, sequence STGMALAQRLGVAESQFSRSLT 529507012122 PS00760 Signal peptidases I lysine active site. 529507012123 1 probable transmembrane helix predicted for PMI2459 by TMHMM2.0 at aa 13-32 529507012124 Signal peptide predicted for PMI2459 by SignalP 2.0 HMM (Signal peptide probability 0.981) with cleavage site probability 0.660 between residues 31 and 32 529507012125 1 probable transmembrane helix predicted for PMI2460 by TMHMM2.0 at aa 7-29 529507012126 Signal peptide predicted for PMI2460 by SignalP 2.0 HMM (Signal peptide probability 0.938) with cleavage site probability 0.257 between residues 24 and 25 529507012127 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 529507012128 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 529507012129 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 529507012130 PS00017 ATP/GTP-binding site motif A (P-loop). 529507012131 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 529507012132 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 529507012133 dimerization domain [polypeptide binding]; other site 529507012134 dimer interface [polypeptide binding]; other site 529507012135 catalytic residues [active] 529507012136 Signal peptide predicted for PMI2462 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 19 and 20 529507012137 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 529507012138 1 probable transmembrane helix predicted for PMI2463 by TMHMM2.0 at aa 13-35 529507012139 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 529507012140 2 probable transmembrane helices predicted for PMI2465 by TMHMM2.0 at aa 13-35 and 50-72 529507012141 Signal peptide predicted for PMI2465 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.988 between residues 32 and 33 529507012142 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 529507012143 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507012144 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 529507012145 HMMPfam hit to PF06447, TraB pilus assembly protein, score 1.7e-223 529507012146 1 probable transmembrane helix predicted for PMI2467 by TMHMM2.0 at aa 16-33 529507012147 conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878 529507012148 TraK protein; Region: TraK; pfam06586 529507012149 Signal peptide predicted for PMI2468 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 30 and 31 529507012150 TraE protein; Region: TraE; cl05060 529507012151 Signal peptide predicted for PMI2469 by SignalP 2.0 HMM (Signal peptide probability 0.934) with cleavage site probability 0.437 between residues 40 and 41 529507012152 1 probable transmembrane helix predicted for PMI2469 by TMHMM2.0 at aa 21-40 529507012153 TraL protein; Region: TraL; cl06278 529507012154 1 probable transmembrane helix predicted for PMI2470 by TMHMM2.0 at aa 29-51 529507012155 replicative DNA helicase; Provisional; Region: PRK05973 529507012156 Domain of unknown function (DUF4400); Region: DUF4400; pfam14348 529507012157 4 probable transmembrane helices predicted for PMI2473 by TMHMM2.0 at aa 9-28, 123-145, 165-187 and 191-210 529507012158 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 529507012159 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 529507012160 PS00017 ATP/GTP-binding site motif A (P-loop). 529507012161 Signal peptide predicted for PMI2475 by SignalP 2.0 HMM (Signal peptide probability 0.839) with cleavage site probability 0.828 between residues 31 and 32 529507012162 Putative helicase; Region: TraI_2; pfam07514 529507012163 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 529507012164 HMMPfam hit to PF07514, helicase, score 9.4e-189 529507012165 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 529507012166 Part of AAA domain; Region: AAA_19; pfam13245 529507012167 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 529507012168 Family description; Region: UvrD_C_2; pfam13538 529507012169 HMMPfam hit to PF00580, UvrD/REP helicase, score 7.1e-09 529507012170 PS00017 ATP/GTP-binding site motif A (P-loop). 529507012171 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 529507012172 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 529507012173 ATP binding site [chemical binding]; other site 529507012174 putative Mg++ binding site [ion binding]; other site 529507012175 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 529507012176 ATP-binding site [chemical binding]; other site 529507012177 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 529507012178 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.4e-13 529507012179 PS00190 Cytochrome c family heme-binding site signature. 529507012180 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 1.5e-16 529507012181 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 529507012182 PS00092 N-6 Adenine-specific DNA methylases signature. 529507012183 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 529507012184 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 529507012185 ATP binding site [chemical binding]; other site 529507012186 putative Mg++ binding site [ion binding]; other site 529507012187 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 529507012188 nucleotide binding region [chemical binding]; other site 529507012189 ATP-binding site [chemical binding]; other site 529507012190 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.6e-12 529507012191 HMMPfam hit to PF00176, SNF2 family N-terminal domain, score 1.8e-07 529507012192 PS00108 Serine/Threonine protein kinases active-site signature. 529507012193 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 6.6e-07 529507012194 Predicted transcriptional regulator [Transcription]; Region: COG2378 529507012195 WYL domain; Region: WYL; pfam13280 529507012196 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 529507012197 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 529507012198 active site 529507012199 catalytic site [active] 529507012200 substrate binding site [chemical binding]; other site 529507012201 HMMPfam hit to PF00929, Exonuclease, score 1.8e-08 529507012202 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 529507012203 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 529507012204 Catalytic site [active] 529507012205 HMMPfam hit to PF00717, Peptidase S24-like, score 1.6e-19 529507012206 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 529507012207 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 529507012208 active site 529507012209 DNA binding site [nucleotide binding] 529507012210 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 529507012211 HMMPfam hit to PF00817, impB/mucB/samB family, score 8.7e-166 529507012212 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 529507012213 PRTRC system protein D; Region: PRTRC_D; TIGR03739 529507012214 Mg binding site [ion binding]; other site 529507012215 nucleotide binding site [chemical binding]; other site 529507012216 putative protofilament interface [polypeptide binding]; other site 529507012217 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 529507012218 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 529507012219 active site 529507012220 Int/Topo IB signature motif; other site 529507012221 HMMPfam hit to PF00589, Phage integrase family, score 2.7e-07 529507012222 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 529507012223 N-terminus of peptide chain release factor 3 generated by the insertion of the conjugative element; N-terminus of peptide chain release factor 3 (fragment) 529507012224 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 529507012225 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 529507012226 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 529507012227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 529507012228 Coenzyme A binding pocket [chemical binding]; other site 529507012229 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 2.9e-17 529507012230 DNA polymerase III subunit psi; Validated; Region: PRK06856 529507012231 HMMPfam hit to PF03603, DNA polymerase III psi subunit, score 4.4e-11 529507012232 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 529507012233 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 529507012234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507012235 S-adenosylmethionine binding site [chemical binding]; other site 529507012236 HMMPfam hit to PF05175, Methyltransferase small domain, score 1.7e-05 529507012237 PS00092 N-6 Adenine-specific DNA methylases signature. 529507012238 HMMPfam hit to PF05175, Methyltransferase small domain, score 1.5e-17 529507012239 2 probable transmembrane helices predicted for PMI2497 by TMHMM2.0 at aa 30-52 and 67-89 529507012240 Signal peptide predicted for PMI2497 by SignalP 2.0 HMM (Signal peptide probability 0.852) with cleavage site probability 0.565 between residues 41 and 42 529507012241 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 529507012242 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 529507012243 Coenzyme A binding pocket [chemical binding]; other site 529507012244 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.8e-11 529507012245 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 529507012246 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 529507012247 PhoU domain; Region: PhoU; pfam01895 529507012248 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 529507012249 8 probable transmembrane helices predicted for PMI2499 by TMHMM2.0 at aa 4-26, 67-89, 99-121, 134-156, 171-193, 206-228, 238-260 and 273-295 529507012250 HMMPfam hit to PF02690, Na+/Pi-cotransporter, score 7e-55 529507012251 alkaline phosphatase; Provisional; Region: PRK10518 529507012252 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 529507012253 dimer interface [polypeptide binding]; other site 529507012254 active site 529507012255 HMMPfam hit to PF00245, Alkaline phosphatase, score 1.1e-120 529507012256 PS00017 ATP/GTP-binding site motif A (P-loop). 529507012257 PS00123 Alkaline phosphatase active site. 529507012258 1 probable transmembrane helix predicted for PMI2500 by TMHMM2.0 at aa 9-31 529507012259 Signal peptide predicted for PMI2500 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.867 between residues 27 and 28 529507012260 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 529507012261 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 529507012262 Probable transposase; Region: OrfB_IS605; pfam01385 529507012263 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 529507012264 HMMPfam hit to PF07282, transposase DNA-binding domai, score 2.8e-34 529507012265 HMMPfam hit to PF01385, Probable transposase, score 7.8e-130 529507012266 Transposase IS200 like; Region: Y1_Tnp; pfam01797 529507012267 HMMPfam hit to PF01797, Transposase IS200 like, score 2.3e-41 529507012268 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507012269 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 529507012270 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 529507012271 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 529507012272 HMMPfam hit to PF00756, esterase, score 7.4e-29 529507012273 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 529507012274 TPR motif; other site 529507012275 binding surface 529507012276 Uncharacterized conserved protein [Function unknown]; Region: COG1434 529507012277 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 529507012278 putative active site [active] 529507012279 HMMPfam hit to PF02698, DUF218 domain, score 3.8e-38 529507012280 Signal peptide predicted for PMI2504 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.980 between residues 33 and 34 529507012281 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507012282 non-specific DNA binding site [nucleotide binding]; other site 529507012283 salt bridge; other site 529507012284 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 529507012285 sequence-specific DNA binding site [nucleotide binding]; other site 529507012286 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 529507012287 active site 529507012288 nucleotide binding site [chemical binding]; other site 529507012289 HIGH motif; other site 529507012290 KMSKS motif; other site 529507012291 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 529507012292 PS00687 Aldehyde dehydrogenases glutamic acid active site. 529507012293 PS00017 ATP/GTP-binding site motif A (P-loop). 529507012294 HMMPfam hit to PF01381, Helix-turn-helix, score 6.7e-09 529507012295 Predicted helix-turn-helix motif with score 1538.000, SD 4.43 at aa 16-37, sequence YTLQQVADESQMTKGYLSQLIN 529507012296 DNA repair protein RadA; Provisional; Region: PRK11823 529507012297 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 529507012298 Walker A motif/ATP binding site; other site 529507012299 ATP binding site [chemical binding]; other site 529507012300 Walker B motif; other site 529507012301 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 529507012302 PS00017 ATP/GTP-binding site motif A (P-loop). 529507012303 PS00190 Cytochrome c family heme-binding site signature. 529507012304 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 529507012305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 529507012306 motif II; other site 529507012307 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.6e-26 529507012308 hypothetical protein; Provisional; Region: PRK11246 529507012309 Signal peptide predicted for PMI2508 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.451 between residues 40 and 41 529507012310 2 probable transmembrane helices predicted for PMI2508 by TMHMM2.0 at aa 15-34 and 169-191 529507012311 hypothetical protein; Provisional; Region: PRK10977 529507012312 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 529507012313 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 529507012314 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 529507012315 FeS/SAM binding site; other site 529507012316 PS01087 Radical activating enzymes signature. 529507012317 HMMPfam hit to PF04055, Radical SAM superfamily, score 7.7e-12 529507012318 PS00190 Cytochrome c family heme-binding site signature. 529507012319 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.00099 529507012320 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507012321 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507012322 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 529507012323 Autotransporter beta-domain; Region: Autotransporter; pfam03797 529507012324 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 529507012325 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 529507012326 Walker A/P-loop; other site 529507012327 ATP binding site [chemical binding]; other site 529507012328 Q-loop/lid; other site 529507012329 ABC transporter signature motif; other site 529507012330 Walker B; other site 529507012331 D-loop; other site 529507012332 H-loop/switch region; other site 529507012333 HMMPfam hit to PF00005, ABC transporter, score 5.9e-22 529507012334 PS00211 ABC transporters family signature. 529507012335 PS00017 ATP/GTP-binding site motif A (P-loop). 529507012336 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 529507012337 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 529507012338 Walker A/P-loop; other site 529507012339 ATP binding site [chemical binding]; other site 529507012340 Q-loop/lid; other site 529507012341 ABC transporter signature motif; other site 529507012342 Walker B; other site 529507012343 D-loop; other site 529507012344 H-loop/switch region; other site 529507012345 HMMPfam hit to PF00005, ABC transporter, score 1.7e-28 529507012346 PS00017 ATP/GTP-binding site motif A (P-loop). 529507012347 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 529507012348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507012349 dimer interface [polypeptide binding]; other site 529507012350 conserved gate region; other site 529507012351 ABC-ATPase subunit interface; other site 529507012352 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 9.4e-24 529507012353 5 probable transmembrane helices predicted for PMI2514 by TMHMM2.0 at aa 10-29, 69-91, 106-128, 189-211 and 231-253 529507012354 PS00215 Mitochondrial energy transfer proteins signature. 529507012355 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 529507012356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507012357 dimer interface [polypeptide binding]; other site 529507012358 conserved gate region; other site 529507012359 putative PBP binding loops; other site 529507012360 ABC-ATPase subunit interface; other site 529507012361 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 5.2e-47 529507012362 6 probable transmembrane helices predicted for PMI2515 by TMHMM2.0 at aa 12-34, 72-94, 106-128, 148-170, 190-212 and 294-316 529507012363 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 529507012364 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 529507012365 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 4.1e-75 529507012366 Signal peptide predicted for PMI2516 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.873 between residues 28 and 29 529507012367 putative glycosyl transferase; Provisional; Region: PRK10073 529507012368 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 529507012369 active site 529507012370 HMMPfam hit to PF00535, Glycosyl transferase, score 4.4e-37 529507012371 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 529507012372 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 529507012373 nickel binding site [ion binding]; other site 529507012374 HMMPfam hit to PF01750, Hydrogenase maturation protease, score 9.8e-27 529507012375 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 529507012376 HMMPfam hit to PF07450, Formate hydrogenlyase maturation protein Hyc, score 2e-65 529507012377 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 529507012378 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 Kd sub, score 1.1e-46 529507012379 hydrogenase 4 subunit H; Validated; Region: PRK08222 529507012380 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 529507012381 PS00190 Cytochrome c family heme-binding site signature. 529507012382 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 2.2e-06 529507012383 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507012384 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 5.6e-07 529507012385 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507012386 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 529507012387 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 529507012388 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 529507012389 HMMPfam hit to PF00346, Respiratory-chain NADH dehydrogenase,, score 3.2e-14 529507012390 PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. 529507012391 HMMPfam hit to PF00329, Respiratory-chain NADH dehydrogenase,, score 7.4e-26 529507012392 hydrogenase 4 subunit F; Validated; Region: PRK06458 529507012393 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 529507012394 12 probable transmembrane helices predicted for PMI2523 by TMHMM2.0 at aa 4-26, 33-55, 75-97, 118-140, 164-186, 216-238, 253-275, 288-307, 322-344, 382-404, 419-437 and 457-479 529507012395 HMMPfam hit to PF00361, NADH-Ubiquinone/plastoquinone (complex I), score 2.4e-59 529507012396 Signal peptide predicted for PMI2523 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.576 between residues 29 and 30 529507012397 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 529507012398 HMMPfam hit to PF00420, NADH-ubiquinone/plastoquinone oxidoreduct, score 1.2e-08 529507012399 6 probable transmembrane helices predicted for PMI2524 by TMHMM2.0 at aa 5-24, 28-50, 57-79, 92-114, 127-149 and 176-195 529507012400 hydrogenase 4 subunit D; Validated; Region: PRK06525 529507012401 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 529507012402 14 probable transmembrane helices predicted for PMI2525 by TMHMM2.0 at aa 6-25, 32-54, 83-105, 118-138, 142-159, 172-191, 211-233, 246-268, 273-295, 302-324, 334-353, 374-396, 416-438 and 459-481 529507012403 HMMPfam hit to PF00361, NADH-Ubiquinone/plastoquinone (complex I), score 3.7e-55 529507012404 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 529507012405 Signal peptide predicted for PMI2525 by SignalP 2.0 HMM (Signal peptide probability 0.744) with cleavage site probability 0.248 between residues 30 and 31 529507012406 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 529507012407 NADH dehydrogenase; Region: NADHdh; cl00469 529507012408 HMMPfam hit to PF00146, NADH dehydrogenase, score 1.1e-41 529507012409 8 probable transmembrane helices predicted for PMI2526 by TMHMM2.0 at aa 10-32, 72-94, 99-121, 141-163, 178-197, 233-252, 257-279 and 292-314 529507012410 PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. 529507012411 hydrogenase 4 subunit B; Validated; Region: PRK06521 529507012412 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 529507012413 16 probable transmembrane helices predicted for PMI2527 by TMHMM2.0 at aa 5-24, 31-53, 79-101, 108-130, 134-153, 165-187, 202-224, 237-259, 272-294, 301-323, 338-360, 373-395, 429-451, 472-494, 529-551 and 651-670 529507012414 HMMPfam hit to PF00361, NADH-Ubiquinone/plastoquinone (complex I), score 4.4e-50 529507012415 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 529507012416 4Fe-4S binding domain; Region: Fer4; pfam00037 529507012417 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 5.9e-08 529507012418 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507012419 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 529507012420 HMMPfam hit to PF02502, Ribose/Galactose Isomerase, score 1.5e-12 529507012421 elongation factor P; Validated; Region: PRK00529 529507012422 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 529507012423 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 529507012424 RNA binding site [nucleotide binding]; other site 529507012425 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 529507012426 RNA binding site [nucleotide binding]; other site 529507012427 HMMPfam hit to PF01132, Elongation factor P (EF-P), score 1e-112 529507012428 PS01275 Elongation factor P signature. 529507012429 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 529507012430 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 529507012431 FeS/SAM binding site; other site 529507012432 HMMPfam hit to PF04055, Radical SAM superfamily, score 4.4e-13 529507012433 fimbrial operon 12 529507012434 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 529507012435 PapC N-terminal domain; Region: PapC_N; pfam13954 529507012436 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 529507012437 PapC C-terminal domain; Region: PapC_C; pfam13953 529507012438 HMMPfam hit to PF00577, Fimbrial Usher protein, score 1.3e-273 529507012439 Signal peptide predicted for PMI2533 by SignalP 2.0 HMM (Signal peptide probability 0.794) with cleavage site probability 0.490 between residues 26 and 27 529507012440 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 529507012441 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 529507012442 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 529507012443 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 4.2e-16 529507012444 Signal peptide predicted for PMI2534 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.897 between residues 31 and 32 529507012445 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 529507012446 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 529507012447 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 529507012448 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 1.4e-22 529507012449 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 4.6e-19 529507012450 1 probable transmembrane helix predicted for PMI2535 by TMHMM2.0 at aa 7-24 529507012451 Signal peptide predicted for PMI2535 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.957 between residues 23 and 24 529507012452 Fimbrial protein; Region: Fimbrial; pfam00419 529507012453 Signal peptide predicted for PMI2536 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.746 between residues 24 and 25 529507012454 1 probable transmembrane helix predicted for PMI2536 by TMHMM2.0 at aa 7-24 529507012455 Signal peptide predicted for PMI2537 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.500 between residues 27 and 28 529507012456 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 529507012457 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 529507012458 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 529507012459 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 2e-19 529507012460 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 1.2e-19 529507012461 1 probable transmembrane helix predicted for PMI2538 by TMHMM2.0 at aa 7-29 529507012462 Signal peptide predicted for PMI2538 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 27 and 28 529507012463 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507012464 HMMPfam hit to PF00419, Fimbrial protein, score 1.8e-05 529507012465 Signal peptide predicted for PMI2539 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 25 and 26 529507012466 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 529507012467 NADH(P)-binding; Region: NAD_binding_10; pfam13460 529507012468 NAD(P) binding site [chemical binding]; other site 529507012469 putative active site [active] 529507012470 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 529507012471 Signal peptide predicted for PMI2541 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.209 between residues 27 and 28 529507012472 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507012473 3 probable transmembrane helices predicted for PMI2542 by TMHMM2.0 at aa 10-29, 89-106 and 129-151 529507012474 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 529507012475 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 529507012476 ring oligomerisation interface [polypeptide binding]; other site 529507012477 ATP/Mg binding site [chemical binding]; other site 529507012478 stacking interactions; other site 529507012479 hinge regions; other site 529507012480 HMMPfam hit to PF00118, TCP-1/cpn60 chaperonin family, score 4e-191 529507012481 PS00296 Chaperonins cpn60 signature. 529507012482 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 529507012483 oligomerisation interface [polypeptide binding]; other site 529507012484 mobile loop; other site 529507012485 roof hairpin; other site 529507012486 HMMPfam hit to PF00166, Chaperonin 10 Kd subunit, score 4.3e-50 529507012487 PS00681 Chaperonins cpn10 signature. 529507012488 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 529507012489 HMMPfam hit to PF04186, FxsA cytoplasmic membrane protein, score 2e-42 529507012490 3 probable transmembrane helices predicted for PMI2545 by TMHMM2.0 at aa 2-24, 28-47 and 78-100 529507012491 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507012492 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 529507012493 Aspartase; Region: Aspartase; cd01357 529507012494 active sites [active] 529507012495 tetramer interface [polypeptide binding]; other site 529507012496 HMMPfam hit to PF00206, Lyase, score 9.9e-167 529507012497 PS00163 Fumarate lyases signature. 529507012498 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 529507012499 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 529507012500 HMMPfam hit to PF03605, Anaerobic c4-dicarboxylate membrane transpo, score 3.8e-217 529507012501 11 probable transmembrane helices predicted for PMI2547 by TMHMM2.0 at aa 15-37, 50-72, 87-109, 130-152, 172-194, 229-251, 266-285, 292-314, 334-353, 366-388 and 418-440 529507012502 putative transcriptional regulator; Provisional; Region: PRK11640 529507012503 mobile element 529507012504 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 529507012505 active site 529507012506 catalytic residues [active] 529507012507 DNA binding site [nucleotide binding] 529507012508 Int/Topo IB signature motif; other site 529507012509 HMMPfam hit to PF00589, Phage integrase family, score 6.8e-10 529507012510 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 0.36 529507012511 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 529507012512 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 529507012513 HMMPfam hit to PF07515, Protein of unknown function (DUF1528), score 6.2e-08 529507012514 HMMPfam hit to PF07514, helicase, score 1.2e-12 529507012515 1 probable transmembrane helix predicted for PMI2551 by TMHMM2.0 at aa 42-64 529507012516 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 529507012517 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 529507012518 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 529507012519 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 529507012520 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 529507012521 1 probable transmembrane helix predicted for PMI2556 by TMHMM2.0 at aa 114-133 529507012522 1 probable transmembrane helix predicted for PMI2559 by TMHMM2.0 at aa 20-42 529507012523 Signal peptide predicted for PMI2562 by SignalP 2.0 HMM (Signal peptide probability 0.682) with cleavage site probability 0.566 between residues 28 and 29 529507012524 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 529507012525 active site 529507012526 catalytic triad [active] 529507012527 oxyanion hole [active] 529507012528 Signal peptide predicted for PMI2563 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.992 between residues 20 and 21 529507012529 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 529507012530 Integrase; Region: Integrase_1; pfam12835 529507012531 1 probable transmembrane helix predicted for PMI2568 by TMHMM2.0 at aa 4-23 529507012532 1 probable transmembrane helix predicted for PMI2569 by TMHMM2.0 at aa 51-73 529507012533 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 529507012534 5 probable transmembrane helices predicted for PMI2570 by TMHMM2.0 at aa 13-35, 69-91, 362-384, 389-408 and 445-467 529507012535 2 probable transmembrane helices predicted for PMI2571 by TMHMM2.0 at aa 13-35 and 55-74 529507012536 Signal peptide predicted for PMI2571 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.898 between residues 31 and 32 529507012537 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 529507012538 Signal peptide predicted for PMI2572 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.668 between residues 25 and 26 529507012539 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 529507012540 HMMPfam hit to PF07513, Protein of unknown function (DUF1527), score 4.2e-186 529507012541 Signal peptide predicted for PMI2573 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.753 between residues 37 and 38 529507012542 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 529507012543 HMMPfam hit to PF07511, Protein of unknown function (DUF1525), score 2.6e-23 529507012544 1 probable transmembrane helix predicted for PMI2574 by TMHMM2.0 at aa 30-52 529507012545 Signal peptide predicted for PMI2574 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.803 between residues 25 and 26 529507012546 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507012547 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 529507012548 trimer interface [polypeptide binding]; other site 529507012549 YadA-like C-terminal region; Region: YadA; pfam03895 529507012550 HMMPfam hit to PF03895, YadA-like C-terminal region, score 2.5e-06 529507012551 HMMPfam hit to PF05658, Hep_Hag, score 3.6e-05 529507012552 HMMPfam hit to PF05658, Hep_Hag, score 2.6e-05 529507012553 HMMPfam hit to PF05658, Hep_Hag, score 0.023 529507012554 Signal peptide predicted for PMI2575 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.966 between residues 23 and 24 529507012555 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507012556 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 529507012557 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 529507012558 PS00017 ATP/GTP-binding site motif A (P-loop). 529507012559 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 529507012560 Signal peptide predicted for PMI2577 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.873 between residues 26 and 27 529507012561 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507012562 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 529507012563 PS00215 Mitochondrial energy transfer proteins signature. 529507012564 Signal peptide predicted for PMI2579 by SignalP 2.0 HMM (Signal peptide probability 0.807) with cleavage site probability 0.260 between residues 20 and 21 529507012565 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 529507012566 Signal peptide predicted for PMI2580 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.882 between residues 29 and 30 529507012567 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 529507012568 Signal peptide predicted for PMI2581 by SignalP 2.0 HMM (Signal peptide probability 0.973) with cleavage site probability 0.820 between residues 34 and 35 529507012569 conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750 529507012570 2 probable transmembrane helices predicted for PMI2582 by TMHMM2.0 at aa 26-45 and 50-72 529507012571 Protein of unknown function (DUF2976); Region: DUF2976; cl12739 529507012572 3 probable transmembrane helices predicted for PMI2583 by TMHMM2.0 at aa 25-47, 74-96 and 108-130 529507012573 Signal peptide predicted for PMI2583 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.986 between residues 47 and 48 529507012574 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 529507012575 2 probable transmembrane helices predicted for PMI2584 by TMHMM2.0 at aa 20-42 and 62-78 529507012576 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 529507012577 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 529507012578 Signal peptide predicted for PMI2585 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 25 and 26 529507012579 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 529507012580 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 529507012581 3 probable transmembrane helices predicted for PMI2587 by TMHMM2.0 at aa 32-54, 153-175 and 221-243 529507012582 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 529507012583 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 529507012584 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 529507012585 PS00017 ATP/GTP-binding site motif A (P-loop). 529507012586 1 probable transmembrane helix predicted for PMI2589 by TMHMM2.0 at aa 15-34 529507012587 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 529507012588 Signal peptide predicted for PMI2590 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.950 between residues 32 and 33 529507012589 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 529507012590 N-acetyl-D-glucosamine binding site [chemical binding]; other site 529507012591 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 8e-05 529507012592 Signal peptide predicted for PMI2591 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.709 between residues 20 and 21 529507012593 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 529507012594 Signal peptide predicted for PMI2592 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.890 between residues 22 and 23 529507012595 Mitotic checkpoint protein; Region: MAD; pfam05557 529507012596 1 probable transmembrane helix predicted for PMI2593 by TMHMM2.0 at aa 21-43 529507012597 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 529507012598 Signal peptide predicted for PMI2594 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.669 between residues 30 and 31 529507012599 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507012600 IS1004 transposase (pseudogene);This CDS contains an inframe stop codon 529507012601 Predicted helix-turn-helix motif with score 1026.000, SD 2.68 at aa 78-99, sequence WARGYFADTVGVNEVIIRRYVR 529507012602 HMMPfam hit to PF01797, Transposase IS200 like, score 2.4e-37 529507012603 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 529507012604 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 529507012605 N-terminal plug; other site 529507012606 ligand-binding site [chemical binding]; other site 529507012607 HMMPfam hit to PF00593, TonB dependent receptor, score 7.7e-25 529507012608 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 1.8e-11 529507012609 PS00430 TonB-dependent receptor proteins signature 1. 529507012610 Signal peptide predicted for PMI2596 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.864 between residues 25 and 26 529507012611 muropeptide transporter; Validated; Region: ampG; cl17669 529507012612 12 probable transmembrane helices predicted for PMI2597 by TMHMM2.0 at aa 2-24, 29-51, 71-90, 100-122, 143-165, 170-187, 217-239, 249-271, 276-298, 308-330, 343-365 and 370-392 529507012613 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.8e-07 529507012614 Methyltransferase domain; Region: Methyltransf_12; pfam08242 529507012615 Phosphopantetheine attachment site; Region: PP-binding; cl09936 529507012616 Condensation domain; Region: Condensation; pfam00668 529507012617 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 529507012618 Nonribosomal peptide synthase; Region: NRPS; pfam08415 529507012619 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 529507012620 acyl-activating enzyme (AAE) consensus motif; other site 529507012621 AMP binding site [chemical binding]; other site 529507012622 Methyltransferase domain; Region: Methyltransf_12; pfam08242 529507012623 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 529507012624 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 529507012625 Condensation domain; Region: Condensation; pfam00668 529507012626 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 529507012627 Nonribosomal peptide synthase; Region: NRPS; pfam08415 529507012628 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 529507012629 HMMPfam hit to PF00668, Condensation domain, score 3.7e-37 529507012630 HMMPfam hit to PF00501, AMP-binding enzyme, score 2.1e-130 529507012631 PS00455 AMP-binding domain signature. 529507012632 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 5.9e-09 529507012633 HMMPfam hit to PF00668, Condensation domain, score 5.3e-46 529507012634 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 3.1e-05 529507012635 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 529507012636 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 529507012637 active site 529507012638 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 529507012639 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 529507012640 Methyltransferase domain; Region: Methyltransf_12; pfam08242 529507012641 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 529507012642 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 529507012643 NADP binding site [chemical binding]; other site 529507012644 active site 529507012645 Condensation domain; Region: Condensation; pfam00668 529507012646 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 529507012647 Nonribosomal peptide synthase; Region: NRPS; pfam08415 529507012648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507012649 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 529507012650 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 529507012651 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 1.8e-73 529507012652 PS00606 Beta-ketoacyl synthases active site. 529507012653 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 529507012654 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 2.5e-70 529507012655 HMMPfam hit to PF00698, Acyl transferase domain, score 1.2e-32 529507012656 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 2.9e-10 529507012657 PS00012 Phosphopantetheine attachment site. 529507012658 HMMPfam hit to PF00668, Condensation domain, score 6.9e-38 529507012659 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 3.3e-10 529507012660 PS00012 Phosphopantetheine attachment site. 529507012661 HMMPfam hit to PF00975, Thioesterase domain, score 4.7e-06 529507012662 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 529507012663 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 529507012664 HMMPfam hit to PF07414, Yersiniabactin synthetase thiazolinyl reduct, score 2.1e-250 529507012665 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 529507012666 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 529507012667 nucleophilic elbow; other site 529507012668 catalytic triad; other site 529507012669 HMMPfam hit to PF00975, Thioesterase domain, score 1.2e-37 529507012670 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 529507012671 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 529507012672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507012673 Walker A/P-loop; other site 529507012674 ATP binding site [chemical binding]; other site 529507012675 Q-loop/lid; other site 529507012676 ABC transporter signature motif; other site 529507012677 Walker B; other site 529507012678 D-loop; other site 529507012679 H-loop/switch region; other site 529507012680 Signal peptide predicted for PMI2603 by SignalP 2.0 HMM (Signal peptide probability 0.778) with cleavage site probability 0.408 between residues 38 and 39 529507012681 5 probable transmembrane helices predicted for PMI2603 by TMHMM2.0 at aa 22-44, 64-86, 147-169, 249-271 and 281-303 529507012682 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 4.4e-16 529507012683 HMMPfam hit to PF00005, ABC transporter, score 6.7e-63 529507012684 PS00017 ATP/GTP-binding site motif A (P-loop). 529507012685 PS00211 ABC transporters family signature. 529507012686 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 529507012687 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 529507012688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507012689 Walker A/P-loop; other site 529507012690 ATP binding site [chemical binding]; other site 529507012691 Q-loop/lid; other site 529507012692 ABC transporter signature motif; other site 529507012693 Walker B; other site 529507012694 D-loop; other site 529507012695 H-loop/switch region; other site 529507012696 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 2.2e-20 529507012697 6 probable transmembrane helices predicted for PMI2604 by TMHMM2.0 at aa 21-43, 53-75, 132-154, 159-178, 243-265 and 280-302 529507012698 HMMPfam hit to PF00005, ABC transporter, score 5.2e-53 529507012699 PS00017 ATP/GTP-binding site motif A (P-loop). 529507012700 PS00211 ABC transporters family signature. 529507012701 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 529507012702 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 529507012703 HMMPfam hit to PF01648, 4'-phosphopantetheinyl transferase superfami, score 3.3e-20 529507012704 Pseudogene. This CDS contains an in frame stop codon.; conserved hypothetical protein (pseudogene) 529507012705 This CDS is truncated at N-terminus relative to database matches; conserved hypothetical protein (fragment) 529507012706 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 529507012707 HMMPfam hit to PF05930, Prophage CP4-57 regulatory protein (AlpA), score 4.2e-24 529507012708 Predicted helix-turn-helix motif with score 1303.000, SD 3.62 at aa 30-51, sequence LRLKQVEEKTGLKRSQIYLYMK 529507012709 conserved hypothetical protein (fragment) 529507012710 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 529507012711 Transposase; Region: HTH_Tnp_1; cl17663 529507012712 HMMPfam hit to PF01527, Transposase, score 8e-14 529507012713 Predicted helix-turn-helix motif with score 1350.000, SD 3.78 at aa 23-44, sequence YTVADAANAMDVGLSTMTRWVK 529507012714 This CDS is disrupted by the insertion of an IS element.; transposase (pseudogene) 529507012715 Transposase; Region: DEDD_Tnp_IS110; pfam01548 529507012716 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 529507012717 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 529507012718 HMMPfam hit to PF02371, Transposase IS116/IS110/IS902 family, score 2.9e-18 529507012719 This CDS is truncated at the N-terminus relative to database matches.; Almost identical to the C-terminus of PMI2633 (92.5 38d); conserved hypothetical protein (fragment) 529507012720 antirestriction protein (pseudogene);This CDS contains several frameshift mutations. 529507012721 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 529507012722 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 529507012723 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 529507012724 HMMPfam hit to PF00593, TonB dependent receptor, score 1e-17 529507012725 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 1.1e-12 529507012726 Signal peptide predicted for PMI2618 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 20 and 21 529507012727 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 529507012728 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 529507012729 HMMPfam hit to PF00593, TonB dependent receptor, score 3.2e-20 529507012730 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 2.4e-23 529507012731 Signal peptide predicted for PMI2619 by SignalP 2.0 HMM (Signal peptide probability 0.982) with cleavage site probability 0.885 between residues 27 and 28 529507012732 membrane protein (fragment) 529507012733 1 probable transmembrane helix predicted for PMI2621 by TMHMM2.0 at aa 20-42 529507012734 degenerate fimbrial operon 529507012735 fimbrial usher protein (fragment) 529507012736 This CDS contains a frameshift mutation and two in frame stop codons; fimbrial chaperone chaperone (pseudogene) 529507012737 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 1.9e-07 529507012738 fimbrial subunit (fragment) 529507012739 HMMPfam hit to PF00419, Fimbrial protein, score 2.2e-07 529507012740 Signal peptide predicted for PMI2624 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24 529507012741 Also similar to the N-terminus of PMI0307 (75.5 id).; ornithine decarboxylase (fragment) 529507012742 Also highly similar to the N-terminal region of PMI2592 (94.5 38d).; exported protein (fragment) 529507012743 putative transposase; Provisional; Region: PRK09857 529507012744 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 529507012745 HMMPfam hit to PF04754, transposase, YhgA-like, score 5.8e-138 529507012746 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 529507012747 DNA topoisomerase III; Provisional; Region: PRK07726 529507012748 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 529507012749 active site 529507012750 putative interdomain interaction site [polypeptide binding]; other site 529507012751 putative metal-binding site [ion binding]; other site 529507012752 putative nucleotide binding site [chemical binding]; other site 529507012753 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 529507012754 domain I; other site 529507012755 DNA binding groove [nucleotide binding] 529507012756 phosphate binding site [ion binding]; other site 529507012757 domain II; other site 529507012758 domain III; other site 529507012759 nucleotide binding site [chemical binding]; other site 529507012760 catalytic site [active] 529507012761 domain IV; other site 529507012762 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 529507012763 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 3.1e-10 529507012764 HMMPfam hit to PF01131, DNA topoisomerase, score 9e-111 529507012765 HMMPfam hit to PF01751, Toprim domain, score 2.5e-24 529507012766 Signal peptide predicted for PMI2631 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.662 between residues 21 and 22 529507012767 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507012768 Domain of unknown function (DUF1845); Region: DUF1845; cl07481 529507012769 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 529507012770 Helix-turn-helix domain; Region: HTH_36; pfam13730 529507012771 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 529507012772 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 529507012773 ParB-like nuclease domain; Region: ParBc; pfam02195 529507012774 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 529507012775 replicative DNA helicase; Region: DnaB; TIGR00665 529507012776 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 529507012777 Walker A motif; other site 529507012778 ATP binding site [chemical binding]; other site 529507012779 Walker B motif; other site 529507012780 DNA binding loops [nucleotide binding] 529507012781 HMMPfam hit to PF03796, DnaB-like helicase C terminal domain, score 5.1e-107 529507012782 Predicted helix-turn-helix motif with score 1470.000, SD 4.19 at aa 347-368, sequence RSLKALAKELGCPVVALSQLNR 529507012783 PS00017 ATP/GTP-binding site motif A (P-loop). 529507012784 HMMPfam hit to PF00772, DnaB-like helicase N terminal domain, score 9.1e-43 529507012785 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 529507012786 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 529507012787 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 529507012788 P-loop; other site 529507012789 Magnesium ion binding site [ion binding]; other site 529507012790 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 529507012791 integrase (fragment) 529507012792 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 529507012793 Repair protein; Region: Repair_PSII; pfam04536 529507012794 4 probable transmembrane helices predicted for PMI2644 by TMHMM2.0 at aa 5-24, 181-203, 248-270 and 285-307 529507012795 HMMPfam hit to PF04536, Domain of unknown function (DUF477), score 2.6e-41 529507012796 Signal peptide predicted for PMI2644 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.766 between residues 24 and 25 529507012797 PS00430 TonB-dependent receptor proteins signature 1. 529507012798 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 529507012799 HMMPfam hit to PF04011, LemA family, score 3.8e-75 529507012800 PS00017 ATP/GTP-binding site motif A (P-loop). 529507012801 1 probable transmembrane helix predicted for PMI2645 by TMHMM2.0 at aa 4-23 529507012802 Signal peptide predicted for PMI2645 by SignalP 2.0 HMM (Signal peptide probability 0.824) with cleavage site probability 0.548 between residues 22 and 23 529507012803 Signal peptide predicted for PMI2646 by SignalP 2.0 HMM (Signal peptide probability 0.716) with cleavage site probability 0.483 between residues 33 and 34 529507012804 3 probable transmembrane helices predicted for PMI2646 by TMHMM2.0 at aa 13-35, 62-84 and 97-119 529507012805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 529507012806 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 529507012807 1 probable transmembrane helix predicted for PMI2647 by TMHMM2.0 at aa 5-27 529507012808 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507012809 ATPase involved in DNA repair; Region: DUF3686; pfam12458 529507012810 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 529507012811 putative YPXnL-motif binding site; other site 529507012812 AAA domain; Region: AAA_22; pfam13401 529507012813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 529507012814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507012815 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 529507012816 putative substrate translocation pore; other site 529507012817 HMMPfam hit to PF00083, Sugar (and other) transporter, score 1e-41 529507012818 12 probable transmembrane helices predicted for PMI2649 by TMHMM2.0 at aa 21-43, 53-75, 84-103, 108-130, 143-165, 170-192, 243-265, 280-302, 309-331, 335-357, 370-392 and 397-419 529507012819 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.4e-30 529507012820 ferredoxin-like protein FixX; Provisional; Region: PRK15449 529507012821 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 529507012822 putative oxidoreductase FixC; Provisional; Region: PRK10157 529507012823 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 9.9e-15 529507012824 1 probable transmembrane helix predicted for PMI2651 by TMHMM2.0 at aa 7-26 529507012825 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 529507012826 Electron transfer flavoprotein domain; Region: ETF; smart00893 529507012827 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 529507012828 PS00696 Electron transfer flavoprotein alpha-subunit signature. 529507012829 HMMPfam hit to PF00766, Electron transfer flavoprotein alpha subuni, score 8.9e-84 529507012830 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 529507012831 Ligand binding site [chemical binding]; other site 529507012832 Electron transfer flavoprotein domain; Region: ETF; pfam01012 529507012833 HMMPfam hit to PF01012, Electron transfer flavoprotein beta subunit, score 1.3e-90 529507012834 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 529507012835 12 probable transmembrane helices predicted for PMI2654 by TMHMM2.0 at aa 13-30, 50-72, 92-114, 144-163, 184-206, 229-251, 264-286, 312-334, 347-366, 410-432, 445-467 and 472-494 529507012836 HMMPfam hit to PF02028, BCCT family transporter, score 1e-277 529507012837 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 529507012838 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 529507012839 active site 529507012840 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal doma, score 1.6e-47 529507012841 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase, middle domain, score 1.3e-51 529507012842 PS00072 Acyl-CoA dehydrogenases signature 1. 529507012843 HMMPfam hit to PF00441, Acyl-CoA dehydrogenase, C-terminal doma, score 5.9e-61 529507012844 PS00073 Acyl-CoA dehydrogenases signature 2. 529507012845 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 529507012846 CoA-transferase family III; Region: CoA_transf_3; pfam02515 529507012847 HMMPfam hit to PF02515, CoA-transferase family III, score 1.7e-92 529507012848 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 529507012849 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 529507012850 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 529507012851 acyl-activating enzyme (AAE) consensus motif; other site 529507012852 putative AMP binding site [chemical binding]; other site 529507012853 putative active site [active] 529507012854 putative CoA binding site [chemical binding]; other site 529507012855 HMMPfam hit to PF00501, AMP-binding enzyme, score 3.6e-124 529507012856 PS00455 AMP-binding domain signature. 529507012857 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 529507012858 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 529507012859 substrate binding site [chemical binding]; other site 529507012860 oxyanion hole (OAH) forming residues; other site 529507012861 trimer interface [polypeptide binding]; other site 529507012862 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 8e-83 529507012863 PS00166 Enoyl-CoA hydratase/isomerase signature. 529507012864 carnitine operon protein CaiE; Provisional; Region: PRK13627 529507012865 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 529507012866 putative trimer interface [polypeptide binding]; other site 529507012867 putative metal binding site [ion binding]; other site 529507012868 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.25 529507012869 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 55 529507012870 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.081 529507012871 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 529507012872 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 529507012873 active site 529507012874 intersubunit interactions; other site 529507012875 catalytic residue [active] 529507012876 HMMPfam hit to PF00923, Transaldolase, score 7.7e-62 529507012877 PS01054 Transaldolase signature 1. 529507012878 Chitin binding domain; Region: Chitin_bind_3; pfam03067 529507012879 HMMPfam hit to PF03067, Chitin binding domain, score 2.5e-53 529507012880 Signal peptide predicted for PMI2662 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.971 between residues 26 and 27 529507012881 recombination regulator RecX; Reviewed; Region: recX; PRK00117 529507012882 HMMPfam hit to PF02631, RecX family, score 2.8e-13 529507012883 Signal peptide predicted for PMI2664 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 23 and 24 529507012884 Surface antigen; Region: Bac_surface_Ag; pfam01103 529507012885 Signal peptide predicted for PMI2665 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 23 and 24 529507012886 Protein of unknown function (DUF4056); Region: DUF4056; pfam13265 529507012887 Signal peptide predicted for PMI2666 by SignalP 2.0 HMM (Signal peptide probability 0.977) with cleavage site probability 0.770 between residues 25 and 26 529507012888 1 probable transmembrane helix predicted for PMI2666 by TMHMM2.0 at aa 5-24 529507012889 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507012890 hypothetical protein; Provisional; Region: PRK10356 529507012891 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 529507012892 Signal peptide predicted for PMI2667 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.925 between residues 26 and 27 529507012893 1 probable transmembrane helix predicted for PMI2667 by TMHMM2.0 at aa 9-31 529507012894 HMMPfam hit to PF01832, Mannosyl-glycoprotein endo-beta-N-ace, score 1.6e-16 529507012895 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 529507012896 12 probable transmembrane helices predicted for PMI2668 by TMHMM2.0 at aa 4-22, 29-46, 50-67, 74-96, 116-138, 151-168, 188-207, 238-260, 321-343, 364-382, 411-433 and 440-459 529507012897 HMMPfam hit to PF03062, MBOAT family, score 1.4e-49 529507012898 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 529507012899 active site 529507012900 catalytic triad [active] 529507012901 oxyanion hole [active] 529507012902 1 probable transmembrane helix predicted for PMI2669 by TMHMM2.0 at aa 13-30 529507012903 HMMPfam hit to PF04311, Protein of unknown function (DUF459), score 2e-41 529507012904 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 529507012905 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 529507012906 active site 529507012907 oxyanion hole [active] 529507012908 catalytic triad [active] 529507012909 Signal peptide predicted for PMI2670 by SignalP 2.0 HMM (Signal peptide probability 0.961) with cleavage site probability 0.574 between residues 28 and 29 529507012910 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507012911 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 529507012912 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 529507012913 dimer interface [polypeptide binding]; other site 529507012914 putative CheW interface [polypeptide binding]; other site 529507012915 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 529507012916 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 0.002 529507012917 low affinity gluconate transporter; Provisional; Region: PRK10472 529507012918 gluconate transporter; Region: gntP; TIGR00791 529507012919 HMMPfam hit to PF02447, GntP family permease, score 1.5e-215 529507012920 13 probable transmembrane helices predicted for PMI2672 by TMHMM2.0 at aa 4-21, 28-47, 57-79, 109-131, 146-168, 175-197, 228-250, 262-284, 299-316, 329-351, 356-378, 385-407 and 422-444 529507012921 Signal peptide predicted for PMI2672 by SignalP 2.0 HMM (Signal peptide probability 0.982) with cleavage site probability 0.422 between residues 28 and 29 529507012922 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 529507012923 AAA domain; Region: AAA_33; pfam13671 529507012924 ATP-binding site [chemical binding]; other site 529507012925 Gluconate-6-phosphate binding site [chemical binding]; other site 529507012926 HMMPfam hit to PF01202, Shikimate kinase, score 1.7e-06 529507012927 PS00017 ATP/GTP-binding site motif A (P-loop). 529507012928 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 529507012929 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 529507012930 DNA binding site [nucleotide binding] 529507012931 domain linker motif; other site 529507012932 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 529507012933 putative ligand binding site [chemical binding]; other site 529507012934 putative dimerization interface [polypeptide binding]; other site 529507012935 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 6.8e-26 529507012936 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 2e-09 529507012937 Predicted helix-turn-helix motif with score 2043.000, SD 6.15 at aa 6-27, sequence PSLQDVADRVGVTKMTVSRFLR 529507012938 PS00356 Bacterial regulatory proteins, lacI family signature. 529507012939 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 529507012940 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 529507012941 putative metal binding site [ion binding]; other site 529507012942 Signal peptide predicted for PMI2675 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.925 between residues 27 and 28 529507012943 HMMPfam hit to PF01497, Periplasmic binding protein, score 2.9e-06 529507012944 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 529507012945 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 529507012946 ABC-ATPase subunit interface; other site 529507012947 dimer interface [polypeptide binding]; other site 529507012948 putative PBP binding regions; other site 529507012949 Signal peptide predicted for PMI2676 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.659 between residues 21 and 22 529507012950 9 probable transmembrane helices predicted for PMI2676 by TMHMM2.0 at aa 7-29, 58-80, 93-110, 114-136, 148-170, 190-212, 240-262, 272-294 and 307-326 529507012951 HMMPfam hit to PF01032, FecCD transport family, score 1.1e-109 529507012952 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 529507012953 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 529507012954 Walker A/P-loop; other site 529507012955 ATP binding site [chemical binding]; other site 529507012956 Q-loop/lid; other site 529507012957 ABC transporter signature motif; other site 529507012958 Walker B; other site 529507012959 D-loop; other site 529507012960 H-loop/switch region; other site 529507012961 HMMPfam hit to PF00005, ABC transporter, score 6.3e-51 529507012962 PS00017 ATP/GTP-binding site motif A (P-loop). 529507012963 PS00634 Ribosomal protein L30 signature. 529507012964 PS00211 ABC transporters family signature. 529507012965 Predicted helix-turn-helix motif with score 1040.000, SD 2.73 at aa 227-248, sequence LTPEHLAQLYNVKPTDIQAHFY 529507012966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507012967 S-adenosylmethionine binding site [chemical binding]; other site 529507012968 molybdenum transport protein ModD; Provisional; Region: PRK06096 529507012969 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 529507012970 dimerization interface [polypeptide binding]; other site 529507012971 active site 529507012972 HMMPfam hit to PF02749, Quinolinate phosphoribosyl transferase, N-t, score 4.1e-26 529507012973 HMMPfam hit to PF01729, Quinolinate phosphoribosyl transferase, C-t, score 2.2e-53 529507012974 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 529507012975 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 529507012976 N-terminal plug; other site 529507012977 ligand-binding site [chemical binding]; other site 529507012978 Signal peptide predicted for PMI2680 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.991 between residues 20 and 21 529507012979 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 8.5e-16 529507012980 HMMPfam hit to PF00593, TonB dependent receptor, score 4.2e-21 529507012981 low 4096C region region. type III secretion system. 529507012982 Invasion plasmid antigen IpaD; Region: IpaD; cl05827 529507012983 1 probable transmembrane helix predicted for PMI2682 by TMHMM2.0 at aa 150-172 529507012984 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 529507012985 3 probable transmembrane helices predicted for PMI2683 by TMHMM2.0 at aa 421-443, 450-472 and 537-559 529507012986 chaperone protein SicA; Provisional; Region: PRK15331 529507012987 Tetratricopeptide repeat; Region: TPR_3; pfam07720 529507012988 Tetratricopeptide repeat; Region: TPR_3; pfam07720 529507012989 HMMPfam hit to PF07720, Tetratricopeptide repeat, score 4.1e-07 529507012990 HMMPfam hit to PF07720, Tetratricopeptide repeat, score 2.1e-10 529507012991 type III secretion system protein SpaS; Validated; Region: PRK08156 529507012992 HMMPfam hit to PF01312, FlhB HrpN YscU SpaS Family, score 1.5e-89 529507012993 4 probable transmembrane helices predicted for PMI2685 by TMHMM2.0 at aa 28-45, 76-98, 140-162 and 177-199 529507012994 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 529507012995 HMMPfam hit to PF01311, Bacterial export proteins, family, score 2.2e-43 529507012996 6 probable transmembrane helices predicted for PMI2686 by TMHMM2.0 at aa 7-29, 44-64, 71-93, 123-145, 179-201 and 211-233 529507012997 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 529507012998 HMMPfam hit to PF01313, Bacterial export proteins, family, score 1.6e-29 529507012999 2 probable transmembrane helices predicted for PMI2687 by TMHMM2.0 at aa 10-32 and 45-67 529507013000 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 529507013001 HMMPfam hit to PF00813, FliP family, score 1.9e-100 529507013002 4 probable transmembrane helices predicted for PMI2688 by TMHMM2.0 at aa 7-36, 51-73, 156-178 and 183-205 529507013003 PS01061 Flagella transport protein fliP family signature 2. 529507013004 Signal peptide predicted for PMI2688 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.516 between residues 22 and 23 529507013005 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 529507013006 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 529507013007 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) prot, score 2.8e-07 529507013008 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 529507013009 ATP synthase SpaL; Validated; Region: PRK08149 529507013010 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 529507013011 Walker A motif; other site 529507013012 ATP binding site [chemical binding]; other site 529507013013 Walker B motif; other site 529507013014 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleot, score 6.3e-103 529507013015 PS00152 ATP synthase alpha and beta subunits signature. 529507013016 PS00017 ATP/GTP-binding site motif A (P-loop). 529507013017 HMMPfam hit to PF02874, ATP synthase alpha/beta family, beta-ba, score 0.0035 529507013018 Invasion protein B family; Region: Invas_SpaK; cl04129 529507013019 HMMPfam hit to PF03519, Invasion protein B family, score 2.1e-07 529507013020 type III secretion system protein InvA; Provisional; Region: PRK15337 529507013021 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 529507013022 HMMPfam hit to PF00771, FHIPEP family, score 8.5e-294 529507013023 7 probable transmembrane helices predicted for PMI2694 by TMHMM2.0 at aa 13-30, 35-57, 69-91, 106-128, 197-219, 239-261 and 282-304 529507013024 PS00994 Bacterial export FHIPEP family signature. 529507013025 Signal peptide predicted for PMI2694 by SignalP 2.0 HMM (Signal peptide probability 0.686) with cleavage site probability 0.678 between residues 36 and 37 529507013026 type III secretion system regulator InvE; Provisional; Region: PRK15338 529507013027 HrpJ-like domain; Region: HrpJ; cl15454 529507013028 HMMPfam hit to PF02523, InvE invasion protein, score 3.7e-10 529507013029 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 529507013030 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 529507013031 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 529507013032 HMMPfam hit to PF00263, Bacterial type II and III secretion system, score 1.1e-58 529507013033 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 5.6e-10 529507013034 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 1e-05 529507013035 1 probable transmembrane helix predicted for PMI2696 by TMHMM2.0 at aa 7-26 529507013036 Signal peptide predicted for PMI2696 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.996 between residues 25 and 26 529507013037 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 529507013038 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 529507013039 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1e-08 529507013040 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.023 529507013041 Predicted helix-turn-helix motif with score 1151.000, SD 3.11 at aa 158-179, sequence SNIAQIGERYGVSGTHFRRLCK 529507013042 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 529507013043 1 probable transmembrane helix predicted for PMI2698 by TMHMM2.0 at aa 129-146 529507013044 Type III secretion needle MxiH like; Region: MxiH; cl09641 529507013045 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 529507013046 HMMPfam hit to PF01514, Secretory protein of YscJ/FliF family, score 8.7e-37 529507013047 Signal peptide predicted for PMI2701 by SignalP 2.0 HMM (Signal peptide probability 0.975) with cleavage site probability 0.481 between residues 20 and 21 529507013048 1 probable transmembrane helix predicted for PMI2701 by TMHMM2.0 at aa 215-237 529507013049 Bacterial type III secretion apparatus protein (OrgA_MxiK); Region: OrgA_MxiK; cl09716 529507013050 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 529507013051 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 529507013052 DNA binding residues [nucleotide binding] 529507013053 dimer interface [polypeptide binding]; other site 529507013054 [2Fe-2S] cluster binding site [ion binding]; other site 529507013055 HMMPfam hit to PF00376, MerR family regulatory protein, score 1.5e-12 529507013056 PS00552 Bacterial regulatory proteins, merR family signature. 529507013057 Predicted helix-turn-helix motif with score 1192.000, SD 3.25 at aa 12-33, sequence LTVGEVAKRSGVAISTLHFYEE 529507013058 Predicted membrane protein [Function unknown]; Region: COG2259 529507013059 Signal peptide predicted for PMI2706 by SignalP 2.0 HMM (Signal peptide probability 0.819) with cleavage site probability 0.762 between residues 32 and 33 529507013060 HMMPfam hit to PF07681, DoxX, score 2.4e-16 529507013061 4 probable transmembrane helices predicted for PMI2706 by TMHMM2.0 at aa 15-32, 53-72, 76-98 and 105-127 529507013062 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 529507013063 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 529507013064 HlyD family secretion protein; Region: HlyD_3; pfam13437 529507013065 Signal peptide predicted for PMI2707 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.530 between residues 24 and 25 529507013066 1 probable transmembrane helix predicted for PMI2707 by TMHMM2.0 at aa 5-27 529507013067 HMMPfam hit to PF00529, HlyD family secretion protein, score 0.00024 529507013068 multidrug efflux protein; Reviewed; Region: PRK09579 529507013069 Signal peptide predicted for PMI2708 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.554 between residues 30 and 31 529507013070 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 529507013071 10 probable transmembrane helices predicted for PMI2708 by TMHMM2.0 at aa 7-29, 333-352, 359-381, 433-455, 462-484, 521-543, 847-869, 873-895, 944-966 and 981-1003 529507013072 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 529507013073 active site 529507013074 HMMPfam hit to PF00102, Protein-tyrosine phosphatase, score 3.2e-09 529507013075 PS00383 Tyrosine specific protein phosphatases active site. 529507013076 This region is similar to a region witin E.coli PAI_II536 (Dobrindt et al. 2002 I&I 70, 6365-6372) 529507013077 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 529507013078 3 probable transmembrane helices predicted for PMI2710 by TMHMM2.0 at aa 31-53, 57-79 and 86-105 529507013079 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 2.8e-31 529507013080 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 529507013081 3 probable transmembrane helices predicted for PMI2711 by TMHMM2.0 at aa 33-55, 62-84 and 94-111 529507013082 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 2.1e-19 529507013083 Signal peptide predicted for PMI2711 by SignalP 2.0 HMM (Signal peptide probability 0.703) with cleavage site probability 0.409 between residues 21 and 22 529507013084 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 529507013085 Propanediol utilisation protein PduL; Region: PduL; pfam06130 529507013086 Propanediol utilisation protein PduL; Region: PduL; pfam06130 529507013087 HMMPfam hit to PF06130, Propanediol utilisation protein PduL, score 3.7e-119 529507013088 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 529507013089 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 529507013090 Hexamer interface [polypeptide binding]; other site 529507013091 Hexagonal pore residue; other site 529507013092 HMMPfam hit to PF00936, Bacterial microcompartments protein fam, score 1.2e-22 529507013093 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 529507013094 HMMPfam hit to PF04055, Radical SAM superfamily, score 2.2e-14 529507013095 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.0027 529507013096 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 2e-05 529507013097 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507013098 PS01087 Radical activating enzymes signature. 529507013099 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 529507013100 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 529507013101 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 529507013102 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 529507013103 dimer interface [polypeptide binding]; other site 529507013104 active site 529507013105 glycine loop; other site 529507013106 HMMPfam hit to PF01228, Glycine radical, score 1.7e-05 529507013107 PS00850 Glycine radical signature. 529507013108 HMMPfam hit to PF02901, Pyruvate formate lyase, score 6.1e-64 529507013109 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 529507013110 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 529507013111 putative active site [active] 529507013112 metal binding site [ion binding]; metal-binding site 529507013113 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 5.3e-114 529507013114 PS00060 Iron-containing alcohol dehydrogenases signature 2. 529507013115 PS00913 Iron-containing alcohol dehydrogenases signature 1. 529507013116 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 529507013117 Hexamer/Pentamer interface [polypeptide binding]; other site 529507013118 central pore; other site 529507013119 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 529507013120 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 529507013121 putative catalytic cysteine [active] 529507013122 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 529507013123 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 529507013124 Hexamer interface [polypeptide binding]; other site 529507013125 Hexagonal pore residue; other site 529507013126 HMMPfam hit to PF00936, Bacterial microcompartments protein fam, score 3.5e-42 529507013127 PS01139 Bacterial microcompartiments proteins signature. 529507013128 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 529507013129 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 529507013130 Hexamer interface [polypeptide binding]; other site 529507013131 Hexagonal pore residue; other site 529507013132 HMMPfam hit to PF00936, Bacterial microcompartments protein fam, score 2.1e-44 529507013133 PS01139 Bacterial microcompartiments proteins signature. 529507013134 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 529507013135 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 529507013136 Hexamer interface [polypeptide binding]; other site 529507013137 Hexagonal pore residue; other site 529507013138 HMMPfam hit to PF00936, Bacterial microcompartments protein fam, score 2.2e-42 529507013139 PS01139 Bacterial microcompartiments proteins signature. 529507013140 Signal peptide predicted for PMI2723 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.838 between residues 23 and 24 529507013141 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 529507013142 DNA binding site [nucleotide binding] 529507013143 1 probable transmembrane helix predicted for PMI2724 by TMHMM2.0 at aa 175-197 529507013144 HMMPfam hit to PF00486, Transcriptional regulatory protein, C ter, score 0.0002 529507013145 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 529507013146 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 529507013147 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 4.6e-12 529507013148 Predicted helix-turn-helix motif with score 1173.000, SD 3.18 at aa 35-56, sequence LSLNAVAKEAGVSKGGLLHHFP 529507013149 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 529507013150 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 529507013151 homodimer interface [polypeptide binding]; other site 529507013152 substrate-cofactor binding pocket; other site 529507013153 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507013154 catalytic residue [active] 529507013155 HMMPfam hit to PF01053, Cys/Met metabolism PLP-dependent enzy, score 1.8e-216 529507013156 aromatic amino acid exporter; Provisional; Region: PRK11689 529507013157 10 probable transmembrane helices predicted for PMI2727 by TMHMM2.0 at aa 7-26, 32-54, 66-88, 93-115, 120-139, 159-177, 184-206, 211-233, 240-262 and 272-291 529507013158 fimbrial operon 13 529507013159 Fimbrial protein; Region: Fimbrial; cl01416 529507013160 Signal peptide predicted for PMI2728 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24 529507013161 HMMPfam hit to PF00419, Fimbrial protein, score 1.1e-43 529507013162 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 529507013163 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 529507013164 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 529507013165 Signal peptide predicted for PMI2729 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.429 between residues 24 and 25 529507013166 1 probable transmembrane helix predicted for PMI2729 by TMHMM2.0 at aa 7-29 529507013167 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 1.2e-58 529507013168 PS00635 Gram-negative pili assembly chaperone signature. 529507013169 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 4.8e-13 529507013170 outer membrane usher protein; Provisional; Region: PRK15193 529507013171 PapC N-terminal domain; Region: PapC_N; pfam13954 529507013172 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 529507013173 PapC C-terminal domain; Region: PapC_C; pfam13953 529507013174 Signal peptide predicted for PMI2730 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.748 between residues 31 and 32 529507013175 1 probable transmembrane helix predicted for PMI2730 by TMHMM2.0 at aa 12-31 529507013176 HMMPfam hit to PF00577, Fimbrial Usher protein, score 0 529507013177 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507013178 Signal peptide predicted for PMI2731 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.998 between residues 20 and 21 529507013179 HMMPfam hit to PF00419, Fimbrial protein, score 7.4e-31 529507013180 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507013181 Signal peptide predicted for PMI2732 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.950 between residues 24 and 25 529507013182 HMMPfam hit to PF00419, Fimbrial protein, score 0.0016 529507013183 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 529507013184 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507013185 non-specific DNA binding site [nucleotide binding]; other site 529507013186 salt bridge; other site 529507013187 sequence-specific DNA binding site [nucleotide binding]; other site 529507013188 HMMPfam hit to PF01381, Helix-turn-helix, score 4.3e-14 529507013189 Predicted helix-turn-helix motif with score 1821.000, SD 5.39 at aa 25-46, sequence YSGKLFAKELGISQQQLSRYER 529507013190 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 529507013191 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 529507013192 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 1.7e-12 529507013193 PS00017 ATP/GTP-binding site motif A (P-loop). 529507013194 Signal peptide predicted for PMI2734 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 22 and 23 529507013195 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 529507013196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507013197 dimer interface [polypeptide binding]; other site 529507013198 conserved gate region; other site 529507013199 putative PBP binding loops; other site 529507013200 ABC-ATPase subunit interface; other site 529507013201 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.3e-11 529507013202 6 probable transmembrane helices predicted for PMI2735 by TMHMM2.0 at aa 5-27, 64-86, 99-121, 126-148, 176-195 and 230-252 529507013203 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 529507013204 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 529507013205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507013206 dimer interface [polypeptide binding]; other site 529507013207 conserved gate region; other site 529507013208 putative PBP binding loops; other site 529507013209 ABC-ATPase subunit interface; other site 529507013210 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 5.1e-17 529507013211 6 probable transmembrane helices predicted for PMI2736 by TMHMM2.0 at aa 12-34, 70-92, 99-121, 152-174, 195-217 and 251-273 529507013212 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 529507013213 Signal peptide predicted for PMI2736 by SignalP 2.0 HMM (Signal peptide probability 0.785) with cleavage site probability 0.371 between residues 38 and 39 529507013214 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 529507013215 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 529507013216 Walker A/P-loop; other site 529507013217 ATP binding site [chemical binding]; other site 529507013218 Q-loop/lid; other site 529507013219 ABC transporter signature motif; other site 529507013220 Walker B; other site 529507013221 D-loop; other site 529507013222 H-loop/switch region; other site 529507013223 TOBE domain; Region: TOBE_2; pfam08402 529507013224 HMMPfam hit to PF00005, ABC transporter, score 4.5e-70 529507013225 PS00211 ABC transporters family signature. 529507013226 PS00017 ATP/GTP-binding site motif A (P-loop). 529507013227 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 529507013228 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 529507013229 putative active site [active] 529507013230 putative catalytic triad [active] 529507013231 HMMPfam hit to PF00082, Subtilase family, score 6.3e-09 529507013232 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 529507013233 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 529507013234 FMN binding site [chemical binding]; other site 529507013235 active site 529507013236 catalytic residues [active] 529507013237 substrate binding site [chemical binding]; other site 529507013238 HMMPfam hit to PF01207, Dihydrouridine synthase (Dus), score 3e-134 529507013239 PS01136 Uncharacterized protein family UPF0034 signature. 529507013240 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 529507013241 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 529507013242 NADP binding site [chemical binding]; other site 529507013243 dimer interface [polypeptide binding]; other site 529507013244 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 1.4e-76 529507013245 PS01162 Quinone oxidoreductase / zeta-crystallin signature. 529507013246 replicative DNA helicase; Provisional; Region: PRK08006 529507013247 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 529507013248 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 529507013249 Walker A motif; other site 529507013250 ATP binding site [chemical binding]; other site 529507013251 Walker B motif; other site 529507013252 DNA binding loops [nucleotide binding] 529507013253 HMMPfam hit to PF00772, DnaB-like helicase N terminal domain, score 7.5e-56 529507013254 HMMPfam hit to PF03796, DnaB-like helicase C terminal domain, score 4.1e-137 529507013255 PS00017 ATP/GTP-binding site motif A (P-loop). 529507013256 Predicted helix-turn-helix motif with score 1279.000, SD 3.54 at aa 374-395, sequence RSLKALAKELQVPVVALSQLNR 529507013257 alanine racemase; Reviewed; Region: alr; PRK00053 529507013258 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 529507013259 active site 529507013260 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 529507013261 substrate binding site [chemical binding]; other site 529507013262 catalytic residues [active] 529507013263 dimer interface [polypeptide binding]; other site 529507013264 HMMPfam hit to PF01168, Alanine racemase, N-terminal domain, score 2.4e-84 529507013265 PS00395 Alanine racemase pyridoxal-phosphate attachment site. 529507013266 HMMPfam hit to PF00842, Alanine racemase, C-terminal domain, score 2.7e-67 529507013267 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 529507013268 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 529507013269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507013270 homodimer interface [polypeptide binding]; other site 529507013271 catalytic residue [active] 529507013272 HMMPfam hit to PF00155, Aminotransferase class I and II, score 2.4e-90 529507013273 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 529507013274 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 529507013275 HMMPfam hit to PF06354, Protein of unknown function (DUF1063), score 8.3e-199 529507013276 serine transporter; Region: stp; TIGR00814 529507013277 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 529507013278 11 probable transmembrane helices predicted for PMI2745 by TMHMM2.0 at aa 41-63, 68-90, 116-138, 153-172, 192-209, 224-246, 267-289, 317-339, 364-383, 388-410 and 423-442 529507013279 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 529507013280 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 529507013281 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 529507013282 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 529507013283 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 529507013284 HMMPfam hit to PF00005, ABC transporter, score 4.5e-36 529507013285 PS00211 ABC transporters family signature. 529507013286 PS00017 ATP/GTP-binding site motif A (P-loop). 529507013287 HMMPfam hit to PF00005, ABC transporter, score 2.4e-07 529507013288 PS00211 ABC transporters family signature. 529507013289 PS00017 ATP/GTP-binding site motif A (P-loop). 529507013290 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 529507013291 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 529507013292 dimer interface [polypeptide binding]; other site 529507013293 ssDNA binding site [nucleotide binding]; other site 529507013294 tetramer (dimer of dimers) interface [polypeptide binding]; other site 529507013295 HMMPfam hit to PF00436, Single-strand binding protein family, score 7.3e-39 529507013296 PS00735 Single-strand binding protein family signature 1. 529507013297 PS00736 Single-strand binding protein family signature 2. 529507013298 ferric uptake regulator; Provisional; Region: fur; PRK09462 529507013299 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 529507013300 metal binding site 2 [ion binding]; metal-binding site 529507013301 putative DNA binding helix; other site 529507013302 metal binding site 1 [ion binding]; metal-binding site 529507013303 dimer interface [polypeptide binding]; other site 529507013304 structural Zn2+ binding site [ion binding]; other site 529507013305 HMMPfam hit to PF01475, Ferric uptake regulator family, score 8.3e-07 529507013306 PS00190 Cytochrome c family heme-binding site signature. 529507013307 LexA repressor; Validated; Region: PRK00215 529507013308 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 529507013309 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 529507013310 Catalytic site [active] 529507013311 HMMPfam hit to PF00717, Peptidase S24-like, score 2.7e-21 529507013312 HMMPfam hit to PF01726, LexA DNA binding domain, score 9.5e-37 529507013313 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 529507013314 3 probable transmembrane helices predicted for PMI2750 by TMHMM2.0 at aa 36-53, 57-79 and 100-122 529507013315 HMMPfam hit to PF01219, Prokaryotic diacylglycerol kinase, score 6.8e-54 529507013316 PS01069 Prokaryotic diacylglycerol kinase signature. 529507013317 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 529507013318 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 529507013319 putative acyl-acceptor binding pocket; other site 529507013320 HMMPfam hit to PF01553, Acyltransferase, score 3e-41 529507013321 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 529507013322 UbiA prenyltransferase family; Region: UbiA; pfam01040 529507013323 7 probable transmembrane helices predicted for PMI2752 by TMHMM2.0 at aa 19-36, 94-127, 134-156, 160-179, 209-228, 233-248 and 261-283 529507013324 HMMPfam hit to PF01040, UbiA prenyltransferase family, score 1.4e-81 529507013325 PS00041 Bacterial regulatory proteins, araC family signature. 529507013326 PS00943 UbiA prenyltransferase family signature. 529507013327 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 529507013328 HMMPfam hit to PF04345, Chorismate lyase, score 1.1e-20 529507013329 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 529507013330 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 529507013331 active site 529507013332 dimer interface [polypeptide binding]; other site 529507013333 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 529507013334 dimer interface [polypeptide binding]; other site 529507013335 active site 529507013336 HMMPfam hit to PF00342, Phosphoglucose isomerase, score 0 529507013337 PS00174 Phosphoglucose isomerase signature 2. 529507013338 PS00765 Phosphoglucose isomerase signature 1. 529507013339 aspartate kinase III; Validated; Region: PRK09084 529507013340 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 529507013341 nucleotide binding site [chemical binding]; other site 529507013342 substrate binding site [chemical binding]; other site 529507013343 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 529507013344 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 529507013345 dimer interface [polypeptide binding]; other site 529507013346 HMMPfam hit to PF00696, Amino acid kinase family, score 3.6e-51 529507013347 PS00324 Aspartokinase signature. 529507013348 PS00017 ATP/GTP-binding site motif A (P-loop). 529507013349 HMMPfam hit to PF01842, ACT domain, score 0.00026 529507013350 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 529507013351 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 529507013352 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 529507013353 substrate binding pocket [chemical binding]; other site 529507013354 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 529507013355 B12 binding site [chemical binding]; other site 529507013356 cobalt ligand [ion binding]; other site 529507013357 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 529507013358 HMMPfam hit to PF02965, Vitamin B12 dependent methionine synth, score 2.9e-163 529507013359 HMMPfam hit to PF02310, B12 binding domain, score 9.1e-26 529507013360 HMMPfam hit to PF02607, B12 binding domain, score 4e-44 529507013361 HMMPfam hit to PF00809, Pterin binding enzyme, score 2e-77 529507013362 HMMPfam hit to PF02574, Homocysteine S-methyltransferase, score 4.3e-148 529507013363 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507013364 transcriptional repressor IclR; Provisional; Region: PRK11569 529507013365 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 529507013366 Bacterial transcriptional regulator; Region: IclR; pfam01614 529507013367 Predicted helix-turn-helix motif with score 999.000, SD 2.59 at aa 47-68, sequence IALTDLAFQAGLPNSTTHRLLT 529507013368 HMMPfam hit to PF01614, Bacterial transcriptional regulator, score 9.1e-69 529507013369 phosphogluconate dehydratase; Validated; Region: PRK09054 529507013370 6-phosphogluconate dehydratase; Region: edd; TIGR01196 529507013371 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507013372 HMMPfam hit to PF00920, Dehydratase family, score 1.6e-263 529507013373 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 529507013374 PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 529507013375 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 529507013376 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 529507013377 active site 529507013378 intersubunit interface [polypeptide binding]; other site 529507013379 catalytic residue [active] 529507013380 HMMPfam hit to PF01081, KDPG and KHG aldolase, score 4.2e-129 529507013381 PS00159 KDPG and KHG aldolases active site. 529507013382 PS00160 KDPG and KHG aldolases Schiff-base forming residue. 529507013383 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 529507013384 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 529507013385 HMMPfam hit to PF06315, Isocitrate dehydrogenase kinase/phosphatase, score 0 529507013386 PS00017 ATP/GTP-binding site motif A (P-loop). 529507013387 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 529507013388 isocitrate lyase; Provisional; Region: PRK15063 529507013389 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 529507013390 tetramer interface [polypeptide binding]; other site 529507013391 active site 529507013392 Mg2+/Mn2+ binding site [ion binding]; other site 529507013393 HMMPfam hit to PF00463, Isocitrate lyase family, score 9.5e-267 529507013394 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 529507013395 PS00161 Isocitrate lyase signature. 529507013396 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 529507013397 malate synthase A; Region: malate_syn_A; TIGR01344 529507013398 active site 529507013399 HMMPfam hit to PF01274, Malate synthase, score 1.8e-294 529507013400 Predicted helix-turn-helix motif with score 1150.000, SD 3.10 at aa 439-460, sequence YGLMEDAATAEISRTSIWQWIR 529507013401 PS00510 Malate synthase signature. 529507013402 homoserine O-succinyltransferase; Provisional; Region: PRK05368 529507013403 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 529507013404 proposed active site lysine [active] 529507013405 conserved cys residue [active] 529507013406 HMMPfam hit to PF04204, Homoserine O-succinyltransferase, score 1.9e-213 529507013407 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 529507013408 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 529507013409 dimer interface [polypeptide binding]; other site 529507013410 active site 529507013411 metal binding site [ion binding]; metal-binding site 529507013412 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 9.7e-49 529507013413 PS00435 Peroxidases proximal heme-ligand signature. 529507013414 PS00687 Aldehyde dehydrogenases glutamic acid active site. 529507013415 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 529507013416 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 529507013417 active site 529507013418 metal binding site [ion binding]; metal-binding site 529507013419 nudix motif; other site 529507013420 HMMPfam hit to PF00293, NUDIX domain, score 8.8e-16 529507013421 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 529507013422 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 529507013423 purine monophosphate binding site [chemical binding]; other site 529507013424 dimer interface [polypeptide binding]; other site 529507013425 putative catalytic residues [active] 529507013426 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 529507013427 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 529507013428 HMMPfam hit to PF02142, MGS-like domain, score 4e-62 529507013429 HMMPfam hit to PF01808, AICARFT/IMPCHase bienzyme, score 1.8e-199 529507013430 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 529507013431 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 529507013432 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 529507013433 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 529507013434 HMMPfam hit to PF02844, Phosphoribosylglycinamide synthetase, N doma, score 1.5e-64 529507013435 HMMPfam hit to PF02842, Phosphoribosylglycinamide synthetase, B doma, score 8.2e-48 529507013436 HMMPfam hit to PF01071, Phosphoribosylglycinamide synthetase, ATP-gr, score 1.3e-91 529507013437 PS00184 Phosphoribosylglycinamide synthetase signature. 529507013438 HMMPfam hit to PF02843, Phosphoribosylglycinamide synthetase, C doma, score 9e-45 529507013439 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 529507013440 HMMPfam hit to PF07356, Protein of unknown function (DUF1481), score 1.7e-73 529507013441 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507013442 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 529507013443 IHF dimer interface [polypeptide binding]; other site 529507013444 IHF - DNA interface [nucleotide binding]; other site 529507013445 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 6.5e-52 529507013446 PS00045 Bacterial histone-like DNA-binding proteins signature. 529507013447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 529507013448 HMMPfam hit to PF04222, Protein of unknown function, DUF, score 3.4e-144 529507013449 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 529507013450 Active_site [active] 529507013451 HMMPfam hit to PF04493, Endonuclease V, score 2.9e-88 529507013452 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 529507013453 substrate binding site [chemical binding]; other site 529507013454 active site 529507013455 HMMPfam hit to PF01208, Uroporphyrinogen decarboxylase (URO-D), score 3.8e-203 529507013456 PS00907 Uroporphyrinogen decarboxylase signature 2. 529507013457 PS00906 Uroporphyrinogen decarboxylase signature 1. 529507013458 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 529507013459 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 529507013460 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 529507013461 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 529507013462 putative NADH binding site [chemical binding]; other site 529507013463 putative active site [active] 529507013464 nudix motif; other site 529507013465 putative metal binding site [ion binding]; other site 529507013466 HMMPfam hit to PF00293, NUDIX domain, score 1.9e-21 529507013467 PS00893 mutT domain signature. 529507013468 PS00190 Cytochrome c family heme-binding site signature. 529507013469 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 529507013470 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 529507013471 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 529507013472 ThiC-associated domain; Region: ThiC-associated; pfam13667 529507013473 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 529507013474 HMMPfam hit to PF01964, ThiC family, score 0 529507013475 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 529507013476 thiamine phosphate binding site [chemical binding]; other site 529507013477 active site 529507013478 pyrophosphate binding site [ion binding]; other site 529507013479 HMMPfam hit to PF02581, Thiamine monophosphate synthase/TENI, score 9e-75 529507013480 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 529507013481 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 529507013482 ATP binding site [chemical binding]; other site 529507013483 substrate interface [chemical binding]; other site 529507013484 HMMPfam hit to PF00899, ThiF family, score 3.6e-53 529507013485 1 probable transmembrane helix predicted for PMI2779 by TMHMM2.0 at aa 32-54 529507013486 HMMPfam hit to PF05237, MoeZ/MoeB domain, score 2.4e-31 529507013487 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 529507013488 thiS-thiF/thiG interaction site; other site 529507013489 HMMPfam hit to PF02597, ThiS family, score 6.9e-14 529507013490 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 529507013491 ThiS interaction site; other site 529507013492 putative active site [active] 529507013493 tetramer interface [polypeptide binding]; other site 529507013494 HMMPfam hit to PF05690, Thiazole biosynthesis protein ThiG, score 7.9e-161 529507013495 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 529507013496 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 529507013497 FeS/SAM binding site; other site 529507013498 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 529507013499 HMMPfam hit to PF04055, Radical SAM superfamily, score 3.3e-05 529507013500 HMMPfam hit to PF06968, Biotin and Thiamin Synthesis associated d, score 8.9e-40 529507013501 putative transposase; Provisional; Region: PRK09857 529507013502 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 529507013503 HMMPfam hit to PF04754, transposase, YhgA-like, score 4.8e-88 529507013504 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 529507013505 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 529507013506 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 529507013507 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 529507013508 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 529507013509 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 529507013510 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 529507013511 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 529507013512 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 529507013513 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 529507013514 DNA binding site [nucleotide binding] 529507013515 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 529507013516 HMMPfam hit to PF04998, RNA polymerase Rpb1, domain, score 7.1e-77 529507013517 HMMPfam hit to PF05000, RNA polymerase Rpb1, domain, score 2.3e-31 529507013518 HMMPfam hit to PF04983, RNA polymerase Rpb1, domain, score 7.3e-47 529507013519 HMMPfam hit to PF00623, RNA polymerase Rpb1, domain, score 6.1e-82 529507013520 HMMPfam hit to PF04997, RNA polymerase Rpb1, domain, score 4.9e-159 529507013521 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 529507013522 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 529507013523 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 529507013524 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 529507013525 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 529507013526 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 529507013527 RPB3 interaction site [polypeptide binding]; other site 529507013528 RPB1 interaction site [polypeptide binding]; other site 529507013529 RPB11 interaction site [polypeptide binding]; other site 529507013530 RPB10 interaction site [polypeptide binding]; other site 529507013531 HMMPfam hit to PF04560, RNA polymerase Rpb2, domain, score 5.7e-52 529507013532 HMMPfam hit to PF00562, RNA polymerase Rpb2, domain, score 4.5e-183 529507013533 PS01166 RNA polymerases beta chain signature. 529507013534 PS00223 Annexins repeated domain signature. 529507013535 HMMPfam hit to PF04565, RNA polymerase Rpb2, domain, score 9.4e-45 529507013536 HMMPfam hit to PF04563, RNA polymerase beta subunit, score 1.3e-07 529507013537 HMMPfam hit to PF04561, RNA polymerase Rpb2, domain, score 4.1e-09 529507013538 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 529507013539 core dimer interface [polypeptide binding]; other site 529507013540 peripheral dimer interface [polypeptide binding]; other site 529507013541 L10 interface [polypeptide binding]; other site 529507013542 L11 interface [polypeptide binding]; other site 529507013543 putative EF-Tu interaction site [polypeptide binding]; other site 529507013544 putative EF-G interaction site [polypeptide binding]; other site 529507013545 HMMPfam hit to PF00542, Ribosomal protein L7/L12 C-terminal dom, score 2.2e-36 529507013546 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 529507013547 23S rRNA interface [nucleotide binding]; other site 529507013548 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 529507013549 HMMPfam hit to PF00466, Ribosomal protein L10, score 4.3e-39 529507013550 PS01109 Ribosomal protein L10 signature. 529507013551 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 529507013552 mRNA/rRNA interface [nucleotide binding]; other site 529507013553 HMMPfam hit to PF00687, Ribosomal protein L1p/L10e family, score 2.7e-124 529507013554 PS01199 Ribosomal protein L1 signature. 529507013555 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 529507013556 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 529507013557 23S rRNA interface [nucleotide binding]; other site 529507013558 L7/L12 interface [polypeptide binding]; other site 529507013559 putative thiostrepton binding site; other site 529507013560 L25 interface [polypeptide binding]; other site 529507013561 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00359 Ribosomal protein L11 signature. 529507013562 HMMPfam hit to PF00298, Ribosomal protein L11, RNA binding do, score 3e-38 529507013563 HMMPfam hit to PF03946, Ribosomal protein L11, N-terminal dom, score 1.7e-38 529507013564 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 529507013565 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 529507013566 putative homodimer interface [polypeptide binding]; other site 529507013567 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 529507013568 heterodimer interface [polypeptide binding]; other site 529507013569 homodimer interface [polypeptide binding]; other site 529507013570 PS01014 Transcription termination factor nusG signature. 529507013571 HMMPfam hit to PF00467, KOW motif, score 1.9e-11 529507013572 HMMPfam hit to PF02357, Transcription termination factor nusG, score 5.3e-21 529507013573 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 529507013574 HMMPfam hit to PF00584, SecE/Sec61-gamma subunits of protein translo, score 1.4e-23 529507013575 3 probable transmembrane helices predicted for PMI2791 by TMHMM2.0 at aa 15-34, 41-63 and 94-116 529507013576 PS01067 Protein secE/sec61-gamma signature. 529507013577 elongation factor Tu; Reviewed; Region: PRK00049 529507013578 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 529507013579 G1 box; other site 529507013580 GEF interaction site [polypeptide binding]; other site 529507013581 GTP/Mg2+ binding site [chemical binding]; other site 529507013582 Switch I region; other site 529507013583 G2 box; other site 529507013584 G3 box; other site 529507013585 Switch II region; other site 529507013586 G4 box; other site 529507013587 G5 box; other site 529507013588 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 529507013589 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 529507013590 Antibiotic Binding Site [chemical binding]; other site 529507013591 HMMPfam hit to PF03143, Elongation factor Tu C-terminal domain, score 9.6e-62 529507013592 HMMPfam hit to PF03144, Elongation factor Tu domain, score 9.4e-26 529507013593 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 5.4e-98 529507013594 PS00301 GTP-binding elongation factors signature. 529507013595 PS00017 ATP/GTP-binding site motif A (P-loop). 529507013596 elongation factor G; Reviewed; Region: PRK00007 529507013597 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 529507013598 G1 box; other site 529507013599 putative GEF interaction site [polypeptide binding]; other site 529507013600 GTP/Mg2+ binding site [chemical binding]; other site 529507013601 Switch I region; other site 529507013602 G2 box; other site 529507013603 G3 box; other site 529507013604 Switch II region; other site 529507013605 G4 box; other site 529507013606 G5 box; other site 529507013607 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 529507013608 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 529507013609 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 529507013610 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 1.2e-49 529507013611 HMMPfam hit to PF03764, Elongation factor G, domain IV, score 5.3e-72 529507013612 HMMPfam hit to PF03144, Elongation factor Tu domain, score 1e-21 529507013613 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 3.8e-109 529507013614 PS00301 GTP-binding elongation factors signature. 529507013615 PS00017 ATP/GTP-binding site motif A (P-loop). 529507013616 30S ribosomal protein S7; Validated; Region: PRK05302 529507013617 HMMPfam hit to PF00177, Ribosomal protein S7p/S5e, score 1.4e-86 529507013618 PS00052 Ribosomal protein S7 signature. 529507013619 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 529507013620 S17 interaction site [polypeptide binding]; other site 529507013621 S8 interaction site; other site 529507013622 16S rRNA interaction site [nucleotide binding]; other site 529507013623 streptomycin interaction site [chemical binding]; other site 529507013624 23S rRNA interaction site [nucleotide binding]; other site 529507013625 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 529507013626 HMMPfam hit to PF00164, Ribosomal protein S12, score 3e-75 529507013627 PS00055 Ribosomal protein S12 signature. 529507013628 DsrH like protein; Region: DsrH; cl17347 529507013629 HMMPfam hit to PF04077, DsrH like protein, score 3.4e-23 529507013630 sulfur relay protein TusC; Validated; Region: PRK00211 529507013631 HMMPfam hit to PF02635, DsrE/DsrF-like family, score 1.4e-34 529507013632 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 529507013633 HMMPfam hit to PF02635, DsrE/DsrF-like family, score 1.9e-46 529507013634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 529507013635 YheO-like PAS domain; Region: PAS_6; pfam08348 529507013636 HTH domain; Region: HTH_22; pfam13309 529507013637 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 529507013638 10 probable transmembrane helices predicted for PMI2800 by TMHMM2.0 at aa 7-29, 39-56, 69-91, 95-114, 123-142, 147-166, 173-195, 205-227, 234-256 and 261-280 529507013639 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1e-09 529507013640 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.7e-15 529507013641 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 529507013642 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 529507013643 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 529507013644 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 1.9e-43 529507013645 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 529507013646 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 529507013647 HMMPfam hit to PF01346, Domain amino terminal to FKBP-type peptidyl-, score 2.6e-39 529507013648 Signal peptide predicted for PMI2801 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 25 and 26 529507013649 SlyX; Region: SlyX; pfam04102 529507013650 HMMPfam hit to PF04102, SlyX, score 2.4e-24 529507013651 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 529507013652 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 529507013653 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 0.00064 529507013654 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 529507013655 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 529507013656 Signal peptide predicted for PMI2804 by SignalP 2.0 HMM (Signal peptide probability 0.953) with cleavage site probability 0.952 between residues 19 and 20 529507013657 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 529507013658 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 529507013659 TrkA-N domain; Region: TrkA_N; pfam02254 529507013660 HMMPfam hit to PF02254, TrkA-N domain, score 2e-18 529507013661 12 probable transmembrane helices predicted for PMI2805 by TMHMM2.0 at aa 5-24, 31-50, 55-74, 87-109, 114-136, 149-171, 181-201, 222-244, 269-291, 296-318, 328-350 and 357-379 529507013662 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 529507013663 HMMPfam hit to PF02525, Flavodoxin-like fold, score 7.7e-51 529507013664 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 529507013665 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 529507013666 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 529507013667 ABC transporter; Region: ABC_tran_2; pfam12848 529507013668 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 529507013669 HMMPfam hit to PF00005, ABC transporter, score 1.3e-41 529507013670 PS00017 ATP/GTP-binding site motif A (P-loop). 529507013671 PS00211 ABC transporters family signature. 529507013672 HMMPfam hit to PF00005, ABC transporter, score 1.2e-38 529507013673 PS00017 ATP/GTP-binding site motif A (P-loop). 529507013674 PS00211 ABC transporters family signature. 529507013675 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 529507013676 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 529507013677 dimerization interface [polypeptide binding]; other site 529507013678 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 529507013679 dimer interface [polypeptide binding]; other site 529507013680 putative CheW interface [polypeptide binding]; other site 529507013681 Signal peptide predicted for PMI2808 by SignalP 2.0 HMM (Signal peptide probability 0.933) with cleavage site probability 0.604 between residues 25 and 26 529507013682 2 probable transmembrane helices predicted for PMI2808 by TMHMM2.0 at aa 7-29 and 191-213 529507013683 HMMPfam hit to PF00672, HAMP domain, score 3.7e-09 529507013684 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 1.8e-91 529507013685 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 529507013686 HAMP domain; Region: HAMP; pfam00672 529507013687 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 529507013688 dimer interface [polypeptide binding]; other site 529507013689 putative CheW interface [polypeptide binding]; other site 529507013690 Signal peptide predicted for PMI2809 by SignalP 2.0 HMM (Signal peptide probability 0.734) with cleavage site probability 0.368 between residues 25 and 26 529507013691 2 probable transmembrane helices predicted for PMI2809 by TMHMM2.0 at aa 27-49 and 210-232 529507013692 HMMPfam hit to PF00672, HAMP domain, score 5.6e-09 529507013693 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 1.1e-82 529507013694 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 529507013695 HMMPfam hit to PF05638, Protein of unknown function (DUF796), score 1.3e-60 529507013696 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 529507013697 PAS domain; Region: PAS_9; pfam13426 529507013698 putative active site [active] 529507013699 heme pocket [chemical binding]; other site 529507013700 HAMP domain; Region: HAMP; pfam00672 529507013701 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 529507013702 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 529507013703 dimer interface [polypeptide binding]; other site 529507013704 putative CheW interface [polypeptide binding]; other site 529507013705 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 9e-73 529507013706 HMMPfam hit to PF00672, HAMP domain, score 0.00092 529507013707 1 probable transmembrane helix predicted for PMI2813 by TMHMM2.0 at aa 171-193 529507013708 HMMPfam hit to PF00785, PAC motif, score 0.00092 529507013709 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 529507013710 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 529507013711 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 529507013712 putative active site [active] 529507013713 HMMPfam hit to PF01380, SIS domain, score 2e-25 529507013714 HMMPfam hit to PF01418, Helix-turn-helix domain, rpiR family, score 2.2e-31 529507013715 PS00430 TonB-dependent receptor proteins signature 1. 529507013716 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 529507013717 HMMPfam hit to PF01810, LysE type translocator, score 6.4e-06 529507013718 6 probable transmembrane helices predicted for PMI2815 by TMHMM2.0 at aa 5-27, 40-62, 66-88, 108-130, 145-167 and 180-200 529507013719 Signal peptide predicted for PMI2815 by SignalP 2.0 HMM (Signal peptide probability 0.856) with cleavage site probability 0.341 between residues 16 and 17 529507013720 putative hydrolase; Provisional; Region: PRK10985 529507013721 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 1.9e-17 529507013722 hypothetical protein; Provisional; Region: PRK04966 529507013723 HMMPfam hit to PF06794, Uncharacterised protein family (UPF0270), score 8.1e-44 529507013724 phosphoribulokinase; Provisional; Region: PRK15453 529507013725 active site 529507013726 Signal peptide predicted for PMI2818 by SignalP 2.0 HMM (Signal peptide probability 0.930) with cleavage site probability 0.340 between residues 36 and 37 529507013727 HMMPfam hit to PF00485, Phosphoribulokinase / Uridine kinase family, score 1.2e-111 529507013728 PS00567 Phosphoribulokinase signature. 529507013729 hypothetical protein; Provisional; Region: PRK10738 529507013730 HMMPfam hit to PF02566, OsmC-like protein, score 3.1e-46 529507013731 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 529507013732 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 529507013733 ligand binding site [chemical binding]; other site 529507013734 flexible hinge region; other site 529507013735 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 529507013736 putative switch regulator; other site 529507013737 non-specific DNA interactions [nucleotide binding]; other site 529507013738 DNA binding site [nucleotide binding] 529507013739 sequence specific DNA binding site [nucleotide binding]; other site 529507013740 putative cAMP binding site [chemical binding]; other site 529507013741 HMMPfam hit to PF00027, Cyclic nucleotide-binding domain, score 7.6e-32 529507013742 PS00888 Cyclic nucleotide-binding domain signature 1. 529507013743 PS00889 Cyclic nucleotide-binding domain signature 2. 529507013744 HMMPfam hit to PF00325, Bacterial regulatory proteins, crp famil, score 1.3e-15 529507013745 PS00042 Bacterial regulatory proteins, crp family signature. 529507013746 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 529507013747 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 529507013748 inhibitor-cofactor binding pocket; inhibition site 529507013749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507013750 catalytic residue [active] 529507013751 HMMPfam hit to PF00202, Aminotransferase class-III, score 1.9e-178 529507013752 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 529507013753 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 529507013754 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 529507013755 glutamine binding [chemical binding]; other site 529507013756 catalytic triad [active] 529507013757 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 9.3e-86 529507013758 PS00442 Glutamine amidotransferases class-I active site. 529507013759 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 529507013760 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 529507013761 active site 529507013762 HMMPfam hit to PF00160, Cyclophilin type peptidyl-prolyl cis-tr, score 1.3e-61 529507013763 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 529507013764 Signal peptide predicted for PMI2823 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.970 between residues 23 and 24 529507013765 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 529507013766 G1 box; other site 529507013767 GTP/Mg2+ binding site [chemical binding]; other site 529507013768 Switch I region; other site 529507013769 G2 box; other site 529507013770 G3 box; other site 529507013771 Switch II region; other site 529507013772 G4 box; other site 529507013773 G5 box; other site 529507013774 HMMPfam hit to PF01926, GTPase of unknown function, score 2.2e-28 529507013775 PS00017 ATP/GTP-binding site motif A (P-loop). 529507013776 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 529507013777 active site 529507013778 catalytic residues [active] 529507013779 metal binding site [ion binding]; metal-binding site 529507013780 HMMPfam hit to PF01327, Polypeptide deformylase, score 6.4e-75 529507013781 DNA polymerase I; Provisional; Region: PRK05755 529507013782 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 529507013783 active site 529507013784 metal binding site 1 [ion binding]; metal-binding site 529507013785 putative 5' ssDNA interaction site; other site 529507013786 metal binding site 3; metal-binding site 529507013787 metal binding site 2 [ion binding]; metal-binding site 529507013788 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 529507013789 putative DNA binding site [nucleotide binding]; other site 529507013790 putative metal binding site [ion binding]; other site 529507013791 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 529507013792 active site 529507013793 catalytic site [active] 529507013794 substrate binding site [chemical binding]; other site 529507013795 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 529507013796 active site 529507013797 DNA binding site [nucleotide binding] 529507013798 catalytic site [active] 529507013799 HMMPfam hit to PF00476, DNA polymerase family A, score 8.7e-206 529507013800 PS00447 DNA polymerase family A signature. 529507013801 HMMPfam hit to PF01612, 3'-5' exonuclease, score 9.8e-58 529507013802 HMMPfam hit to PF01367, 5'-3' exonuclease, C-terminal SAM fold, score 8.3e-51 529507013803 HMMPfam hit to PF02739, 5'-3' exonuclease, N-terminal resolvase-, score 1.2e-94 529507013804 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 529507013805 3 probable transmembrane helices predicted for PMI2827 by TMHMM2.0 at aa 51-73, 88-105 and 112-131 529507013806 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507013807 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 529507013808 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 529507013809 catalytic residues [active] 529507013810 hinge region; other site 529507013811 alpha helical domain; other site 529507013812 HMMPfam hit to PF01323, DSBA-like thioredoxin domain, score 9.7e-40 529507013813 PS00194 Thioredoxin family active site. 529507013814 Signal peptide predicted for PMI2828 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.949 between residues 19 and 20 529507013815 serine/threonine protein kinase; Provisional; Region: PRK11768 529507013816 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 529507013817 HMMPfam hit to PF01636, Phosphotransferase enzyme family, score 3e-34 529507013818 Protein of unknown function (DUF1040); Region: DUF1040; cl01176 529507013819 HMMPfam hit to PF06288, Protein of unknown function (DUF1040), score 2.3e-58 529507013820 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 529507013821 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 529507013822 GTP binding site; other site 529507013823 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 529507013824 Walker A motif; other site 529507013825 HMMPfam hit to PF03205, Molybdopterin guanine dinucleotide synthesis, score 2.2e-56 529507013826 PS00017 ATP/GTP-binding site motif A (P-loop). 529507013827 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 529507013828 homotrimer interaction site [polypeptide binding]; other site 529507013829 putative active site [active] 529507013830 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 3.3e-17 529507013831 PS01094 Uncharacterized protein family UPF0076 signature. 529507013832 Signal peptide predicted for PMI2833 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.979 between residues 21 and 22 529507013833 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 529507013834 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 529507013835 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 4.7e-71 529507013836 1 probable transmembrane helix predicted for PMI2834 by TMHMM2.0 at aa 7-29 529507013837 Signal peptide predicted for PMI2834 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.408 between residues 19 and 20 529507013838 glutathione reductase; Validated; Region: PRK06116 529507013839 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 529507013840 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 529507013841 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 529507013842 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidored, score 4e-50 529507013843 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidored, score 1.4e-90 529507013844 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 529507013845 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 529507013846 HMMPfam hit to PF04378, Protein of unknown function (DUF519), score 1.6e-153 529507013847 PS00092 N-6 Adenine-specific DNA methylases signature. 529507013848 PS00092 N-6 Adenine-specific DNA methylases signature. 529507013849 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 529507013850 Signal peptide predicted for PMI2837 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 20 and 21 529507013851 HMMPfam hit to PF06476, Protein of unknown function (DUF1090), score 9.2e-35 529507013852 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 529507013853 HMMPfam hit to PF03631, Ribonuclease BN-like family, score 3.6e-22 529507013854 6 probable transmembrane helices predicted for PMI2838 by TMHMM2.0 at aa 75-97, 136-155, 186-208, 228-250, 262-284 and 299-321 529507013855 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507013856 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 529507013857 active site 1 [active] 529507013858 dimer interface [polypeptide binding]; other site 529507013859 hexamer interface [polypeptide binding]; other site 529507013860 active site 2 [active] 529507013861 HMMPfam hit to PF01361, Tautomerase enzyme, score 5.9e-25 529507013862 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 529507013863 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 529507013864 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 9e-09 529507013865 HMMPfam hit to PF00675, Insulinase (Peptidase family M16), score 0.16 529507013866 Signal peptide predicted for PMI2840 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.895 between residues 24 and 25 529507013867 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 529507013868 HMMPfam hit to PF00672, HAMP domain, score 0.036 529507013869 2 probable transmembrane helices predicted for PMI2841 by TMHMM2.0 at aa 15-37 and 160-182 529507013870 Signal peptide predicted for PMI2841 by SignalP 2.0 HMM (Signal peptide probability 0.709) with cleavage site probability 0.288 between residues 36 and 37 529507013871 haemagglutination activity domain; Region: Haemagg_act; pfam05860 529507013872 HMMPfam hit to PF05860, haemagglutination activity domain, score 6.9e-22 529507013873 Signal peptide predicted for PMI2842 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.810 between residues 27 and 28 529507013874 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 529507013875 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 529507013876 Walker A/P-loop; other site 529507013877 ATP binding site [chemical binding]; other site 529507013878 Q-loop/lid; other site 529507013879 ABC transporter signature motif; other site 529507013880 Walker B; other site 529507013881 D-loop; other site 529507013882 H-loop/switch region; other site 529507013883 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 529507013884 HMMPfam hit to PF00005, ABC transporter, score 4.3e-60 529507013885 PS00211 ABC transporters family signature. 529507013886 PS00017 ATP/GTP-binding site motif A (P-loop). 529507013887 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 529507013888 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 529507013889 Walker A/P-loop; other site 529507013890 ATP binding site [chemical binding]; other site 529507013891 Q-loop/lid; other site 529507013892 ABC transporter signature motif; other site 529507013893 Walker B; other site 529507013894 D-loop; other site 529507013895 H-loop/switch region; other site 529507013896 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 529507013897 HMMPfam hit to PF00005, ABC transporter, score 8.1e-58 529507013898 PS00211 ABC transporters family signature. 529507013899 PS00017 ATP/GTP-binding site motif A (P-loop). 529507013900 dipeptide transporter; Provisional; Region: PRK10913 529507013901 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 529507013902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507013903 dimer interface [polypeptide binding]; other site 529507013904 conserved gate region; other site 529507013905 putative PBP binding loops; other site 529507013906 ABC-ATPase subunit interface; other site 529507013907 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.7e-47 529507013908 5 probable transmembrane helices predicted for PMI2845 by TMHMM2.0 at aa 31-53, 103-125, 140-162, 215-237 and 265-287 529507013909 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 529507013910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507013911 dimer interface [polypeptide binding]; other site 529507013912 conserved gate region; other site 529507013913 putative PBP binding loops; other site 529507013914 ABC-ATPase subunit interface; other site 529507013915 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.1e-55 529507013916 6 probable transmembrane helices predicted for PMI2846 by TMHMM2.0 at aa 9-31, 99-121, 134-156, 199-221, 259-281 and 309-331 529507013917 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 529507013918 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 529507013919 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 529507013920 peptide binding site [polypeptide binding]; other site 529507013921 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 9.7e-97 529507013922 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 529507013923 Signal peptide predicted for PMI2847 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 28 and 29 529507013924 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 529507013925 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 529507013926 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 529507013927 Signal peptide predicted for PMI2848 by SignalP 2.0 HMM (Signal peptide probability 0.985) with cleavage site probability 0.974 between residues 22 and 23 529507013928 Signal peptide predicted for PMI2849 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.976 between residues 21 and 22 529507013929 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 529507013930 HMMPfam hit to PF07119, Protein of unknown function (DUF1375), score 7.3e-33 529507013931 Signal peptide predicted for PMI2850 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.912 between residues 28 and 29 529507013932 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507013933 putative transporter; Validated; Region: PRK03818 529507013934 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 529507013935 TrkA-C domain; Region: TrkA_C; pfam02080 529507013936 TrkA-C domain; Region: TrkA_C; pfam02080 529507013937 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 529507013938 11 probable transmembrane helices predicted for PMI2851 by TMHMM2.0 at aa 4-23, 30-52, 67-86, 93-115, 160-182, 371-393, 403-425, 438-460, 465-484, 491-513 and 528-550 529507013939 HMMPfam hit to PF06826, Predicted Permease Membrane Region, score 5.6e-62 529507013940 HMMPfam hit to PF02080, TrkA-C domain, score 7.1e-14 529507013941 HMMPfam hit to PF02080, TrkA-C domain, score 3.2e-11 529507013942 HMMPfam hit to PF06826, Predicted Permease Membrane Region, score 4.9e-62 529507013943 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 529507013944 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 529507013945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507013946 homodimer interface [polypeptide binding]; other site 529507013947 catalytic residue [active] 529507013948 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 529507013949 HMMPfam hit to PF03352, Methyladenine glycosylase, score 5.2e-113 529507013950 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 529507013951 dimer interface [polypeptide binding]; other site 529507013952 motif 1; other site 529507013953 active site 529507013954 motif 2; other site 529507013955 motif 3; other site 529507013956 HMMPfam hit to PF02091, Glycyl-tRNA synthetase alpha subunit, score 1.2e-245 529507013957 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 529507013958 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 529507013959 DALR anticodon binding domain; Region: DALR_1; pfam05746 529507013960 HMMPfam hit to PF02092, Glycyl-tRNA synthetase beta subunit, score 0 529507013961 HMMPfam hit to PF05746, DALR anticodon binding domain, score 1.8e-05 529507013962 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 529507013963 HMMPfam hit to PF06296, Protein of unknown function (DUF1044), score 3.8e-42 529507013964 Predicted transcriptional regulator [Transcription]; Region: COG2944 529507013965 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507013966 non-specific DNA binding site [nucleotide binding]; other site 529507013967 salt bridge; other site 529507013968 sequence-specific DNA binding site [nucleotide binding]; other site 529507013969 HMMPfam hit to PF01381, Helix-turn-helix, score 7.6e-07 529507013970 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 529507013971 putative catalytic site [active] 529507013972 putative metal binding site [ion binding]; other site 529507013973 putative phosphate binding site [ion binding]; other site 529507013974 HMMPfam hit to PF03372, Endonuclease/Exonuclease/phosphatase fa, score 0.00023 529507013975 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 529507013976 Predicted membrane protein [Function unknown]; Region: COG2860 529507013977 UPF0126 domain; Region: UPF0126; pfam03458 529507013978 UPF0126 domain; Region: UPF0126; pfam03458 529507013979 HMMPfam hit to PF03458, UPF0126 domain, score 1.3e-36 529507013980 7 probable transmembrane helices predicted for PMI2861 by TMHMM2.0 at aa 5-22, 29-51, 61-80, 87-109, 113-132, 148-169 and 173-190 529507013981 HMMPfam hit to PF03458, UPF0126 domain, score 2.3e-31 529507013982 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 529507013983 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 529507013984 catalytic site [active] 529507013985 G-X2-G-X-G-K; other site 529507013986 PS00017 ATP/GTP-binding site motif A (P-loop). 529507013987 PS00856 Guanylate kinase signature. 529507013988 HMMPfam hit to PF00625, Guanylate kinase, score 2.8e-56 529507013989 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 529507013990 HMMPfam hit to PF01192, RNA polymerase Rpb6, score 1.2e-21 529507013991 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 529507013992 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 529507013993 Zn2+ binding site [ion binding]; other site 529507013994 Mg2+ binding site [ion binding]; other site 529507013995 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 529507013996 synthetase active site [active] 529507013997 NTP binding site [chemical binding]; other site 529507013998 metal binding site [ion binding]; metal-binding site 529507013999 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 529507014000 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 529507014001 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507014002 HMMPfam hit to PF01966, HD domain, score 6.5e-16 529507014003 HMMPfam hit to PF04607, Region found in RelA / SpoT proteins, score 2.4e-47 529507014004 HMMPfam hit to PF02824, TGS domain, score 6.2e-29 529507014005 HMMPfam hit to PF01842, ACT domain, score 0.00091 529507014006 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 529507014007 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 529507014008 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 529507014009 HMMPfam hit to PF00588, SpoU rRNA Methylase family, score 2.4e-45 529507014010 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 529507014011 Y-family of DNA polymerases; Region: PolY; cl12025 529507014012 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 529507014013 generic binding surface II; other site 529507014014 ssDNA binding site; other site 529507014015 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 529507014016 ATP binding site [chemical binding]; other site 529507014017 putative Mg++ binding site [ion binding]; other site 529507014018 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 529507014019 nucleotide binding region [chemical binding]; other site 529507014020 ATP-binding site [chemical binding]; other site 529507014021 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 7.7e-12 529507014022 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 6.5e-06 529507014023 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 4.5e-38 529507014024 PS00017 ATP/GTP-binding site motif A (P-loop). 529507014025 PS00435 Peroxidases proximal heme-ligand signature. 529507014026 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.8e-22 529507014027 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 529507014028 11 probable transmembrane helices predicted for PMI2867 by TMHMM2.0 at aa 4-21, 33-55, 70-87, 94-116, 154-176, 213-235, 245-267, 274-292, 302-324, 336-358 and 368-390 529507014029 HMMPfam hit to PF03616, Sodium/glutamate symporter, score 3.9e-237 529507014030 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 529507014031 HMMPfam hit to PF00860, Permease family, score 1.2e-152 529507014032 11 probable transmembrane helices predicted for PMI2868 by TMHMM2.0 at aa 44-66, 96-118, 128-150, 157-179, 194-213, 220-242, 262-284, 347-369, 379-401, 408-430 and 440-459 529507014033 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 529507014034 PS01116 Xanthine/uracil permeases family signature. 529507014035 AsmA family; Region: AsmA; pfam05170 529507014036 HMMPfam hit to PF07089, Protein of unknown function (DUF1354), score 8.8e-36 529507014037 Signal peptide predicted for PMI2870 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.582 between residues 26 and 27 529507014038 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 529507014039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 529507014040 RNA binding surface [nucleotide binding]; other site 529507014041 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 529507014042 probable active site [active] 529507014043 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 2.1e-24 529507014044 PS01149 Rsu family of pseudouridine synthase signature. 529507014045 HMMPfam hit to PF01479, S4 domain, score 6.6e-14 529507014046 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 529507014047 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 529507014048 Coenzyme A binding pocket [chemical binding]; other site 529507014049 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 529507014050 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 3.3e-17 529507014051 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 529507014052 putative active site [active] 529507014053 dimerization interface [polypeptide binding]; other site 529507014054 putative tRNAtyr binding site [nucleotide binding]; other site 529507014055 HMMPfam hit to PF02580, D-Tyr-tRNA(Tyr) deacylase, score 2.1e-74 529507014056 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 529507014057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 529507014058 motif II; other site 529507014059 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 3.5e-15 529507014060 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 529507014061 non-specific DNA binding site [nucleotide binding]; other site 529507014062 salt bridge; other site 529507014063 sequence-specific DNA binding site [nucleotide binding]; other site 529507014064 HMMPfam hit to PF01381, Helix-turn-helix, score 5.3e-09 529507014065 Signal peptide predicted for PMI2877 by SignalP 2.0 HMM (Signal peptide probability 0.727) with cleavage site probability 0.206 between residues 23 and 24 529507014066 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 529507014067 oligomeric interface; other site 529507014068 putative active site [active] 529507014069 homodimer interface [polypeptide binding]; other site 529507014070 HMMPfam hit to PF01850, PIN domain, score 4.9e-11 529507014071 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 529507014072 HMMPfam hit to PF04014, SpoVT / AbrB like domain, score 2.1e-11 529507014073 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 529507014074 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 529507014075 G1 box; other site 529507014076 putative GEF interaction site [polypeptide binding]; other site 529507014077 GTP/Mg2+ binding site [chemical binding]; other site 529507014078 Switch I region; other site 529507014079 G2 box; other site 529507014080 G3 box; other site 529507014081 Switch II region; other site 529507014082 G4 box; other site 529507014083 G5 box; other site 529507014084 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 529507014085 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 529507014086 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 5.4e-32 529507014087 HMMPfam hit to PF03144, Elongation factor Tu domain, score 5e-13 529507014088 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 1.7e-73 529507014089 PS00301 GTP-binding elongation factors signature. 529507014090 PS00017 ATP/GTP-binding site motif A (P-loop). 529507014091 glutamine synthetase; Provisional; Region: glnA; PRK09469 529507014092 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 529507014093 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 529507014094 HMMPfam hit to PF03951, Glutamine synthetase, beta-Grasp domain, score 4.7e-46 529507014095 PS00180 Glutamine synthetase signature 1. 529507014096 HMMPfam hit to PF00120, Glutamine synthetase, catalytic domain, score 7.6e-164 529507014097 PS00181 Glutamine synthetase ATP-binding region signature. 529507014098 PS00182 Glutamine synthetase class-I adenylation site. 529507014099 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 529507014100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 529507014101 putative active site [active] 529507014102 heme pocket [chemical binding]; other site 529507014103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 529507014104 ATP binding site [chemical binding]; other site 529507014105 Mg2+ binding site [ion binding]; other site 529507014106 G-X-G motif; other site 529507014107 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 3.4e-15 529507014108 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 7.2e-27 529507014109 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 529507014110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507014111 active site 529507014112 phosphorylation site [posttranslational modification] 529507014113 intermolecular recognition site; other site 529507014114 dimerization interface [polypeptide binding]; other site 529507014115 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 529507014116 Walker A motif; other site 529507014117 ATP binding site [chemical binding]; other site 529507014118 Walker B motif; other site 529507014119 arginine finger; other site 529507014120 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 529507014121 HMMPfam hit to PF00072, Response regulator receiver domain, score 9.8e-36 529507014122 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 1.4e-145 529507014123 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 529507014124 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 529507014125 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 2.7e-15 529507014126 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 529507014127 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 529507014128 FeS/SAM binding site; other site 529507014129 HemN C-terminal domain; Region: HemN_C; pfam06969 529507014130 HMMPfam hit to PF06969, HemN C-terminal region, score 8e-51 529507014131 HMMPfam hit to PF04055, Radical SAM superfamily, score 1.3e-25 529507014132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 529507014133 HMMPfam hit to PF05643, bacterial lipoprotein (DUF799), score 1e-69 529507014134 Signal peptide predicted for PMI2886 by SignalP 2.0 HMM (Signal peptide probability 0.980) with cleavage site probability 0.748 between residues 20 and 21 529507014135 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507014136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 529507014137 Signal peptide predicted for PMI2887 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.536 between residues 20 and 21 529507014138 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507014139 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 529507014140 HMMPfam hit to PF03783, Curli production assembly/transport componen, score 1.9e-77 529507014141 PS00017 ATP/GTP-binding site motif A (P-loop). 529507014142 1 probable transmembrane helix predicted for PMI2888 by TMHMM2.0 at aa 20-42 529507014143 Signal peptide predicted for PMI2888 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.213 between residues 24 and 25 529507014144 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507014145 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 529507014146 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 529507014147 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 529507014148 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 529507014149 RNA binding site [nucleotide binding]; other site 529507014150 HMMPfam hit to PF00575, S1 RNA binding domain, score 8.2e-28 529507014151 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 529507014152 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 529507014153 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 529507014154 HMMPfam hit to PF03449, Prokaryotic transcription elongation fact, score 8.5e-39 529507014155 PS00829 Prokaryotic transcription elongation factors signature 1. 529507014156 HMMPfam hit to PF01272, Prokaryotic transcription elongation fact, score 1e-37 529507014157 PS00830 Prokaryotic transcription elongation factors signature 2. 529507014158 osmolarity response regulator; Provisional; Region: ompR; PRK09468 529507014159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507014160 active site 529507014161 phosphorylation site [posttranslational modification] 529507014162 intermolecular recognition site; other site 529507014163 dimerization interface [polypeptide binding]; other site 529507014164 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 529507014165 DNA binding site [nucleotide binding] 529507014166 HMMPfam hit to PF00072, Response regulator receiver domain, score 7e-45 529507014167 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 2.4e-18 529507014168 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 529507014169 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 529507014170 dimerization interface [polypeptide binding]; other site 529507014171 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 529507014172 dimer interface [polypeptide binding]; other site 529507014173 phosphorylation site [posttranslational modification] 529507014174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 529507014175 ATP binding site [chemical binding]; other site 529507014176 Mg2+ binding site [ion binding]; other site 529507014177 G-X-G motif; other site 529507014178 Signal peptide predicted for PMI2892 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.468 between residues 34 and 35 529507014179 2 probable transmembrane helices predicted for PMI2892 by TMHMM2.0 at aa 17-39 and 156-178 529507014180 HMMPfam hit to PF00672, HAMP domain, score 1.7e-10 529507014181 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 2e-12 529507014182 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 2.5e-30 529507014183 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 529507014184 Signal peptide predicted for PMI2893 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.788 between residues 25 and 26 529507014185 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 3.4e-33 529507014186 1 probable transmembrane helix predicted for PMI2893 by TMHMM2.0 at aa 21-43 529507014187 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 529507014188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507014189 dimer interface [polypeptide binding]; other site 529507014190 conserved gate region; other site 529507014191 putative PBP binding loops; other site 529507014192 ABC-ATPase subunit interface; other site 529507014193 6 probable transmembrane helices predicted for PMI2894 by TMHMM2.0 at aa 21-43, 78-100, 112-134, 166-188, 227-249 and 282-304 529507014194 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.5e-12 529507014195 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 529507014196 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 529507014197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507014198 dimer interface [polypeptide binding]; other site 529507014199 conserved gate region; other site 529507014200 putative PBP binding loops; other site 529507014201 ABC-ATPase subunit interface; other site 529507014202 Signal peptide predicted for PMI2895 by SignalP 2.0 HMM (Signal peptide probability 0.817) with cleavage site probability 0.398 between residues 58 and 59 529507014203 6 probable transmembrane helices predicted for PMI2895 by TMHMM2.0 at aa 33-55, 92-114, 127-149, 154-173, 205-227 and 272-294 529507014204 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.8e-38 529507014205 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 529507014206 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 529507014207 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 529507014208 Walker A/P-loop; other site 529507014209 ATP binding site [chemical binding]; other site 529507014210 Q-loop/lid; other site 529507014211 ABC transporter signature motif; other site 529507014212 Walker B; other site 529507014213 D-loop; other site 529507014214 H-loop/switch region; other site 529507014215 HMMPfam hit to PF00005, ABC transporter, score 3.2e-72 529507014216 PS00017 ATP/GTP-binding site motif A (P-loop). 529507014217 PS00211 ABC transporters family signature. 529507014218 transcriptional regulator PhoU; Provisional; Region: PRK11115 529507014219 PhoU domain; Region: PhoU; pfam01895 529507014220 PhoU domain; Region: PhoU; pfam01895 529507014221 HMMPfam hit to PF01895, PhoU family, score 3.7e-32 529507014222 HMMPfam hit to PF01895, PhoU family, score 1.4e-31 529507014223 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 529507014224 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 529507014225 substrate binding pocket [chemical binding]; other site 529507014226 membrane-bound complex binding site; other site 529507014227 hinge residues; other site 529507014228 Signal peptide predicted for PMI2898 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.981 between residues 23 and 24 529507014229 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 3e-65 529507014230 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 529507014231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507014232 dimer interface [polypeptide binding]; other site 529507014233 conserved gate region; other site 529507014234 putative PBP binding loops; other site 529507014235 ABC-ATPase subunit interface; other site 529507014236 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.7e-15 529507014237 4 probable transmembrane helices predicted for PMI2899 by TMHMM2.0 at aa 22-44, 64-86, 106-128 and 211-233 529507014238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507014239 dimer interface [polypeptide binding]; other site 529507014240 conserved gate region; other site 529507014241 putative PBP binding loops; other site 529507014242 ABC-ATPase subunit interface; other site 529507014243 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.4e-20 529507014244 5 probable transmembrane helices predicted for PMI2900 by TMHMM2.0 at aa 27-49, 61-83, 93-115, 161-183 and 198-220 529507014245 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 529507014246 8 probable transmembrane helices predicted for PMI2901 by TMHMM2.0 at aa 13-35, 40-59, 93-115, 125-147, 171-193, 208-230, 265-287 and 291-308 529507014247 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 529507014248 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 529507014249 HMMPfam hit to PF00698, Acyl transferase domain, score 7.1e-07 529507014250 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 529507014251 5 probable transmembrane helices predicted for PMI2903 by TMHMM2.0 at aa 4-26, 39-61, 299-321, 341-363 and 402-424 529507014252 Signal peptide predicted for PMI2904 by SignalP 2.0 HMM (Signal peptide probability 0.722) with cleavage site probability 0.220 between residues 21 and 22 529507014253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507014254 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 529507014255 Walker A/P-loop; other site 529507014256 ATP binding site [chemical binding]; other site 529507014257 Q-loop/lid; other site 529507014258 ABC transporter signature motif; other site 529507014259 Walker B; other site 529507014260 D-loop; other site 529507014261 H-loop/switch region; other site 529507014262 PS00017 ATP/GTP-binding site motif A (P-loop). 529507014263 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 529507014264 Beta-ketoacyl synthase, C-terminal domain; Region: Ketoacyl-synt_C; pfam02801 529507014265 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 7.6e-05 529507014266 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 0.0062 529507014267 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 529507014268 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 529507014269 dimer interface [polypeptide binding]; other site 529507014270 active site 529507014271 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 529507014272 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 529507014273 active site 529507014274 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 1.7e-49 529507014275 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 1.3e-12 529507014276 PS00606 Beta-ketoacyl synthases active site. 529507014277 Signal peptide predicted for PMI2908 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.987 between residues 20 and 21 529507014278 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 529507014279 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 529507014280 HMMPfam hit to PF01571, Glycine cleavage T-protein (aminomethyl tran, score 3.3e-10 529507014281 Phosphopantetheine attachment site; Region: PP-binding; cl09936 529507014282 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 529507014283 active site 2 [active] 529507014284 active site 1 [active] 529507014285 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 529507014286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 529507014287 NAD(P) binding site [chemical binding]; other site 529507014288 active site 529507014289 HMMPfam hit to PF00106, short chain dehydrogenase, score 2.6e-68 529507014290 PS00061 Short-chain dehydrogenases/reductases family signature. 529507014291 PS00108 Serine/Threonine protein kinases active-site signature. 529507014292 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 529507014293 HMMPfam hit to PF01648, 4'-phosphopantetheinyl transferase superfami, score 1.1e-10 529507014294 haemagglutination activity domain; Region: Haemagg_act; pfam05860 529507014295 HMMPfam hit to PF05594, Haemagluttinin repeat, score 0.0043 529507014296 HMMPfam hit to PF05594, Haemagluttinin repeat, score 2 529507014297 HMMPfam hit to PF05594, Haemagluttinin repeat, score 1 529507014298 HMMPfam hit to PF05594, Haemagluttinin repeat, score 1.3 529507014299 HMMPfam hit to PF05594, Haemagluttinin repeat, score 2.2 529507014300 PS00018 EF-hand calcium-binding domain. 529507014301 HMMPfam hit to PF05860, haemagglutination activity domain, score 3.7e-28 529507014302 Signal peptide predicted for PMI2914 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.933 between residues 30 and 31 529507014303 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 529507014304 13 probable transmembrane helices predicted for PMI2915 by TMHMM2.0 at aa 22-44, 59-81, 83-105, 110-132, 139-158, 178-197, 204-226, 241-263, 292-314, 324-346, 351-373, 388-410 and 422-444 529507014305 HMMPfam hit to PF00860, Permease family, score 3.5e-28 529507014306 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 529507014307 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 529507014308 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.9e-14 529507014309 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 529507014310 9 probable transmembrane helices predicted for PMI2917 by TMHMM2.0 at aa 12-34, 75-97, 104-126, 162-184, 196-218, 238-260, 273-290, 300-319 and 326-348 529507014311 Der GTPase activator; Provisional; Region: PRK05244 529507014312 HMMPfam hit to PF04220, Protein of unknown function, DUF414, score 2.9e-41 529507014313 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 529507014314 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 529507014315 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 529507014316 HMMPfam hit to PF04023, FeoA domain, score 1.9e-11 529507014317 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 529507014318 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 529507014319 G1 box; other site 529507014320 GTP/Mg2+ binding site [chemical binding]; other site 529507014321 Switch I region; other site 529507014322 G2 box; other site 529507014323 G3 box; other site 529507014324 Switch II region; other site 529507014325 G4 box; other site 529507014326 G5 box; other site 529507014327 Nucleoside recognition; Region: Gate; pfam07670 529507014328 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 529507014329 Nucleoside recognition; Region: Gate; pfam07670 529507014330 HMMPfam hit to PF01926, GTPase of unknown function, score 3e-40 529507014331 PS00017 ATP/GTP-binding site motif A (P-loop). 529507014332 HMMPfam hit to PF02421, Ferrous iron transport protein B, score 5.5e-46 529507014333 10 probable transmembrane helices predicted for PMI2921 by TMHMM2.0 at aa 289-311, 321-343, 350-372, 387-409, 430-452, 456-478, 515-537, 667-689, 696-718 and 728-747 529507014334 HMMPfam hit to PF07670, Nucleoside recognition, score 3.3e-15 529507014335 PS00017 ATP/GTP-binding site motif A (P-loop). 529507014336 HMMPfam hit to PF07664, Ferrous iron transport protein B C terminus, score 7.8e-25 529507014337 HMMPfam hit to PF07670, Nucleoside recognition, score 1.2e-15 529507014338 FeoC like transcriptional regulator; Region: FeoC; cl17677 529507014339 OsmC-like protein; Region: OsmC; pfam02566 529507014340 carboxylesterase BioH; Provisional; Region: PRK10349 529507014341 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 529507014342 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 1.6e-27 529507014343 DNA utilization protein GntX; Provisional; Region: PRK11595 529507014344 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 529507014345 active site 529507014346 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 529507014347 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 529507014348 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 529507014349 HMMPfam hit to PF01521, HesB-like domain, score 2.8e-39 529507014350 HMMPfam hit to PF01106, NifU-like domain, score 2.2e-07 529507014351 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 529507014352 active site residue [active] 529507014353 HMMPfam hit to PF00581, Rhodanese-like domain, score 3.6e-17 529507014354 intramembrane serine protease GlpG; Provisional; Region: PRK10907 529507014355 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 529507014356 Rhomboid family; Region: Rhomboid; pfam01694 529507014357 6 probable transmembrane helices predicted for PMI2928 by TMHMM2.0 at aa 99-121, 145-167, 180-199, 203-222, 229-251 and 256-273 529507014358 HMMPfam hit to PF01694, Rhomboid family, score 1.5e-29 529507014359 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 529507014360 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 529507014361 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 529507014362 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 3.2e-113 529507014363 PS00894 Bacterial regulatory proteins, deoR family signature. 529507014364 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 529507014365 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 3.8e-68 529507014366 PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1. 529507014367 Uncharacterized conserved protein [Function unknown]; Region: COG3189 529507014368 HMMPfam hit to PF04343, Protein of unknown function, DUF488, score 1.4e-41 529507014369 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 529507014370 FAD binding site [chemical binding]; other site 529507014371 HMMPfam hit to PF02219, Methylenetetrahydrofolate reductase, score 1.8e-158 529507014372 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 529507014373 Transcriptional regulators [Transcription]; Region: PurR; COG1609 529507014374 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 529507014375 DNA binding site [nucleotide binding] 529507014376 domain linker motif; other site 529507014377 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 529507014378 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 0.0017 529507014379 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 529507014380 11 probable transmembrane helices predicted for PMI2935 by TMHMM2.0 at aa 7-29, 39-61, 68-90, 105-127, 134-156, 197-219, 323-345, 360-379, 391-413, 423-445 and 466-488 529507014381 HMMPfam hit to PF01970, Integral membrane protein DUF112, score 2.5e-173 529507014382 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 529507014383 4 probable transmembrane helices predicted for PMI2936 by TMHMM2.0 at aa 7-24, 39-61, 82-115 and 120-142 529507014384 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 529507014385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 529507014386 HMMPfam hit to PF03401, Bordetella uptake gene (bug) product, score 2.7e-32 529507014387 Signal peptide predicted for PMI2937 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 28 and 29 529507014388 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 529507014389 BNR repeat-like domain; Region: BNR_2; pfam13088 529507014390 HMMPfam hit to PF02012, BNR/Asp-box repeat, score 1.7 529507014391 HMMPfam hit to PF02012, BNR/Asp-box repeat, score 8.9 529507014392 HMMPfam hit to PF02012, BNR/Asp-box repeat, score 0.53 529507014393 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 529507014394 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 529507014395 inhibitor site; inhibition site 529507014396 active site 529507014397 dimer interface [polypeptide binding]; other site 529507014398 catalytic residue [active] 529507014399 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase family, score 4.2e-09 529507014400 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 529507014401 hexamer (dimer of trimers) interface [polypeptide binding]; other site 529507014402 substrate binding site [chemical binding]; other site 529507014403 trimer interface [polypeptide binding]; other site 529507014404 Mn binding site [ion binding]; other site 529507014405 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 529507014406 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 529507014407 N- and C-terminal domain interface [polypeptide binding]; other site 529507014408 active site 529507014409 MgATP binding site [chemical binding]; other site 529507014410 catalytic site [active] 529507014411 metal binding site [ion binding]; metal-binding site 529507014412 carbohydrate binding site [chemical binding]; other site 529507014413 putative homodimer interface [polypeptide binding]; other site 529507014414 HMMPfam hit to PF02782, FGGY family of carbohydrate kinases, C-termi, score 6.5e-10 529507014415 HMMPfam hit to PF00370, FGGY family of carbohydrate kinases, N-termi, score 2.9e-11 529507014416 Signal peptide predicted for PMI2942 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 20 and 21 529507014417 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 529507014418 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 529507014419 Walker A/P-loop; other site 529507014420 ATP binding site [chemical binding]; other site 529507014421 Q-loop/lid; other site 529507014422 ABC transporter signature motif; other site 529507014423 Walker B; other site 529507014424 D-loop; other site 529507014425 H-loop/switch region; other site 529507014426 HMMPfam hit to PF00005, ABC transporter, score 2.1e-48 529507014427 PS00211 ABC transporters family signature. 529507014428 PS00017 ATP/GTP-binding site motif A (P-loop). 529507014429 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 529507014430 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 529507014431 Walker A/P-loop; other site 529507014432 ATP binding site [chemical binding]; other site 529507014433 Q-loop/lid; other site 529507014434 ABC transporter signature motif; other site 529507014435 Walker B; other site 529507014436 D-loop; other site 529507014437 H-loop/switch region; other site 529507014438 HMMPfam hit to PF00005, ABC transporter, score 2.9e-47 529507014439 PS00211 ABC transporters family signature. 529507014440 PS00017 ATP/GTP-binding site motif A (P-loop). 529507014441 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 529507014442 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 529507014443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507014444 dimer interface [polypeptide binding]; other site 529507014445 conserved gate region; other site 529507014446 putative PBP binding loops; other site 529507014447 ABC-ATPase subunit interface; other site 529507014448 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.1e-37 529507014449 5 probable transmembrane helices predicted for PMI2945 by TMHMM2.0 at aa 15-37, 80-102, 126-148, 197-219 and 245-267 529507014450 PS00017 ATP/GTP-binding site motif A (P-loop). 529507014451 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 529507014452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507014453 dimer interface [polypeptide binding]; other site 529507014454 conserved gate region; other site 529507014455 putative PBP binding loops; other site 529507014456 ABC-ATPase subunit interface; other site 529507014457 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.2e-51 529507014458 6 probable transmembrane helices predicted for PMI2946 by TMHMM2.0 at aa 12-34, 110-132, 145-167, 177-199, 237-259 and 283-305 529507014459 Signal peptide predicted for PMI2946 by SignalP 2.0 HMM (Signal peptide probability 0.930) with cleavage site probability 0.384 between residues 25 and 26 529507014460 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 529507014461 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 529507014462 substrate binding site [chemical binding]; other site 529507014463 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 1.4e-72 529507014464 Signal peptide predicted for PMI2947 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.981 between residues 23 and 24 529507014465 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507014466 Methyltransferase domain; Region: Methyltransf_31; pfam13847 529507014467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507014468 S-adenosylmethionine binding site [chemical binding]; other site 529507014469 HMMPfam hit to PF01209, ubiE/COQ5 methyltransferase family, score 2.8e-06 529507014470 1 probable transmembrane helix predicted for PMI2949 by TMHMM2.0 at aa 168-190 529507014471 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 529507014472 HMMPfam hit to PF06316, Enterobacterial Ail/Lom protein, score 2.1e-08 529507014473 Signal peptide predicted for PMI2950 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 22 and 23 529507014474 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 529507014475 putative active site [active] 529507014476 YdjC motif; other site 529507014477 Mg binding site [ion binding]; other site 529507014478 putative homodimer interface [polypeptide binding]; other site 529507014479 HMMPfam hit to PF04794, YdjC-like protein, score 9.1e-104 529507014480 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 529507014481 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 529507014482 NAD binding site [chemical binding]; other site 529507014483 sugar binding site [chemical binding]; other site 529507014484 divalent metal binding site [ion binding]; other site 529507014485 tetramer (dimer of dimers) interface [polypeptide binding]; other site 529507014486 dimer interface [polypeptide binding]; other site 529507014487 HMMPfam hit to PF02056, Family 4 glycosyl hydrolase, score 1.6e-211 529507014488 PS01324 Glycosyl hydrolases family 4 signature. 529507014489 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 529507014490 Cupin domain; Region: Cupin_2; pfam07883 529507014491 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 529507014492 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 9e-13 529507014493 PS00041 Bacterial regulatory proteins, araC family signature. 529507014494 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.41 529507014495 HMMPfam hit to PF07883, Cupin domain, score 3e-07 529507014496 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 529507014497 active site 529507014498 methionine cluster; other site 529507014499 phosphorylation site [posttranslational modification] 529507014500 metal binding site [ion binding]; metal-binding site 529507014501 HMMPfam hit to PF02255, PTS system, Lactose/Cellobiose specific IIA, score 7.3e-48 529507014502 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 529507014503 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 529507014504 9 probable transmembrane helices predicted for PMI2955 by TMHMM2.0 at aa 40-62, 83-105, 115-137, 144-166, 186-208, 229-251, 297-319, 359-381 and 406-428 529507014505 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 2.3e-80 529507014506 PS00017 ATP/GTP-binding site motif A (P-loop). 529507014507 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 529507014508 active site 529507014509 P-loop; other site 529507014510 phosphorylation site [posttranslational modification] 529507014511 HMMPfam hit to PF02302, PTS system, Lactose/Cellobiose specific IIB, score 3.6e-27 529507014512 Signal peptide predicted for PMI2956 by SignalP 2.0 HMM (Signal peptide probability 0.832) with cleavage site probability 0.411 between residues 27 and 28 529507014513 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 529507014514 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 529507014515 putative ligand binding residues [chemical binding]; other site 529507014516 Signal peptide predicted for PMI2957 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.982 between residues 24 and 25 529507014517 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507014518 HMMPfam hit to PF01497, Periplasmic binding protein, score 1.1e-48 529507014519 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 529507014520 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 529507014521 ABC-ATPase subunit interface; other site 529507014522 dimer interface [polypeptide binding]; other site 529507014523 putative PBP binding regions; other site 529507014524 Signal peptide predicted for PMI2958 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.915 between residues 25 and 26 529507014525 9 probable transmembrane helices predicted for PMI2958 by TMHMM2.0 at aa 7-29, 49-71, 83-105, 109-131, 136-158, 185-207, 228-250, 265-287 and 294-312 529507014526 HMMPfam hit to PF01032, FecCD transport family, score 1.3e-37 529507014527 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 529507014528 ABC-ATPase subunit interface; other site 529507014529 dimer interface [polypeptide binding]; other site 529507014530 putative PBP binding regions; other site 529507014531 Signal peptide predicted for PMI2959 by SignalP 2.0 HMM (Signal peptide probability 0.785) with cleavage site probability 0.334 between residues 50 and 51 529507014532 9 probable transmembrane helices predicted for PMI2959 by TMHMM2.0 at aa 29-46, 61-83, 88-110, 125-144, 151-173, 193-215, 244-266, 286-308 and 315-332 529507014533 HMMPfam hit to PF01032, FecCD transport family, score 5.8e-14 529507014534 PS00211 ABC transporters family signature. 529507014535 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 529507014536 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 529507014537 Walker A/P-loop; other site 529507014538 ATP binding site [chemical binding]; other site 529507014539 Q-loop/lid; other site 529507014540 ABC transporter signature motif; other site 529507014541 Walker B; other site 529507014542 D-loop; other site 529507014543 H-loop/switch region; other site 529507014544 HMMPfam hit to PF00005, ABC transporter, score 2.7e-50 529507014545 PS00017 ATP/GTP-binding site motif A (P-loop). 529507014546 PS00017 ATP/GTP-binding site motif A (P-loop). 529507014547 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 529507014548 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 529507014549 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 3.8e-08 529507014550 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 529507014551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507014552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507014553 Signal peptide predicted for PMI2962 by SignalP 2.0 HMM (Signal peptide probability 0.853) with cleavage site probability 0.363 between residues 30 and 31 529507014554 14 probable transmembrane helices predicted for PMI2962 by TMHMM2.0 at aa 9-31, 46-68, 75-97, 101-123, 136-158, 163-185, 198-215, 225-242, 263-285, 300-322, 327-349, 359-381, 394-416 and 466-488 529507014555 PS00043 Bacterial regulatory proteins, gntR family signature. 529507014556 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.1e-51 529507014557 Cupin domain; Region: Cupin_2; cl17218 529507014558 Helix-turn-helix domain; Region: HTH_18; pfam12833 529507014559 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 529507014560 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 3.7e-07 529507014561 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.38 529507014562 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 529507014563 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 529507014564 putative [Fe4-S4] binding site [ion binding]; other site 529507014565 putative molybdopterin cofactor binding site [chemical binding]; other site 529507014566 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 529507014567 putative molybdopterin cofactor binding site; other site 529507014568 Signal peptide predicted for PMI2964 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.997 between residues 41 and 42 529507014569 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 do, score 2.7e-08 529507014570 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 2.8e-84 529507014571 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 529507014572 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 2.1e-29 529507014573 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 529507014574 4Fe-4S binding domain; Region: Fer4; pfam00037 529507014575 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.012 529507014576 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507014577 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 7.5e-09 529507014578 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507014579 PS00215 Mitochondrial energy transfer proteins signature. 529507014580 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 529507014581 7 probable transmembrane helices predicted for PMI2966 by TMHMM2.0 at aa 5-27, 40-62, 82-104, 111-133, 148-166, 244-266 and 276-298 529507014582 Transcriptional regulators [Transcription]; Region: PurR; COG1609 529507014583 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 529507014584 DNA binding site [nucleotide binding] 529507014585 domain linker motif; other site 529507014586 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 529507014587 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI family, score 4.9e-10 529507014588 PS00356 Bacterial regulatory proteins, lacI family signature. 529507014589 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 529507014590 putative hydrolase; Provisional; Region: PRK02113 529507014591 nucleoside transporter; Region: 2A0110; TIGR00889 529507014592 Signal peptide predicted for PMI2969 by SignalP 2.0 HMM (Signal peptide probability 0.722) with cleavage site probability 0.419 between residues 45 and 46 529507014593 HMMPfam hit to PF03825, Nucleoside H+ symporter, score 7.2e-66 529507014594 12 probable transmembrane helices predicted for PMI2969 by TMHMM2.0 at aa 7-29, 39-61, 73-92, 97-119, 126-148, 158-177, 207-229, 244-263, 270-292, 296-313, 334-356 and 371-393 529507014595 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 0.00019 529507014596 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 529507014597 MgtC family; Region: MgtC; pfam02308 529507014598 4 probable transmembrane helices predicted for PMI2970 by TMHMM2.0 at aa 10-32, 44-66, 81-100 and 113-135 529507014599 HMMPfam hit to PF02308, MgtC family, score 4e-57 529507014600 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 529507014601 11 probable transmembrane helices predicted for PMI2971 by TMHMM2.0 at aa 9-25, 35-57, 77-94, 134-156, 169-186, 196-218, 223-240, 244-266, 279-301, 316-333 and 346-365 529507014602 HMMPfam hit to PF01757, Acyltransferase family, score 1.9e-53 529507014603 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 529507014604 Class I aldolases; Region: Aldolase_Class_I; cl17187 529507014605 catalytic residue [active] 529507014606 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase family, score 1.7e-17 529507014607 Signal peptide predicted for PMI2973 by SignalP 2.0 HMM (Signal peptide probability 0.794) with cleavage site probability 0.733 between residues 16 and 17 529507014608 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 529507014609 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 529507014610 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 529507014611 putative active site [active] 529507014612 HMMPfam hit to PF01380, SIS domain, score 1.4e-24 529507014613 HMMPfam hit to PF01418, Helix-turn-helix domain, rpiR family, score 1.1e-31 529507014614 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 529507014615 HMMPfam hit to PF04074, Domain of unknown function (DUF386), score 2.6e-58 529507014616 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 529507014617 Na binding site [ion binding]; other site 529507014618 13 probable transmembrane helices predicted for PMI2976 by TMHMM2.0 at aa 6-28, 41-63, 78-100, 121-143, 158-180, 187-209, 229-248, 278-300, 315-337, 379-396, 406-428, 435-454 and 458-480 529507014619 HMMPfam hit to PF00474, Sodium:solute symporter family, score 4.4e-10 529507014620 N-acetylmannosamine kinase; Provisional; Region: PRK05082 529507014621 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 529507014622 nucleotide binding site [chemical binding]; other site 529507014623 HMMPfam hit to PF00480, ROK family, score 8.1e-65 529507014624 PS01125 ROK family signature. 529507014625 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 529507014626 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 529507014627 putative active site cavity [active] 529507014628 HMMPfam hit to PF04131, N-acetylmannosamine-6-phosphate epi, score 1.8e-120 529507014629 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 529507014630 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 529507014631 [4Fe-4S] binding site [ion binding]; other site 529507014632 molybdopterin cofactor binding site; other site 529507014633 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 529507014634 molybdopterin cofactor binding site; other site 529507014635 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 6.6e-24 529507014636 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 5.1e-135 529507014637 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 529507014638 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 do, score 3.8e-15 529507014639 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 529507014640 Na2 binding site [ion binding]; other site 529507014641 putative substrate binding site 1 [chemical binding]; other site 529507014642 Na binding site 1 [ion binding]; other site 529507014643 putative substrate binding site 2 [chemical binding]; other site 529507014644 Signal peptide predicted for PMI2980 by SignalP 2.0 HMM (Signal peptide probability 0.620) with cleavage site probability 0.445 between residues 33 and 34 529507014645 HMMPfam hit to PF00209, Sodium:neurotransmitter symporter family, score 2.4e-12 529507014646 11 probable transmembrane helices predicted for PMI2980 by TMHMM2.0 at aa 7-26, 36-58, 82-104, 138-160, 167-189, 215-237, 250-272, 287-309, 338-360, 375-397 and 418-437 529507014647 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 529507014648 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 529507014649 tetramer interface [polypeptide binding]; other site 529507014650 active site 529507014651 HMMPfam hit to PF00206, Lyase, score 3.5e-09 529507014652 PS00163 Fumarate lyases signature. 529507014653 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 529507014654 PTS system, maltose and glucose-specific IIBC component; Region: PTS-IIBC-malX; TIGR02004 529507014655 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 529507014656 active site turn [active] 529507014657 phosphorylation site [posttranslational modification] 529507014658 HMMPfam hit to PF00367, phosphotransferase system, EIIB, score 7.6e-10 529507014659 10 probable transmembrane helices predicted for PMI2982 by TMHMM2.0 at aa 15-37, 58-80, 90-112, 132-154, 176-198, 205-227, 286-308, 321-343, 348-370 and 391-413 529507014660 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 6.1e-43 529507014661 Signal peptide predicted for PMI2982 by SignalP 2.0 HMM (Signal peptide probability 0.893) with cleavage site probability 0.370 between residues 38 and 39 529507014662 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 529507014663 transcriptional regulator MurR; Provisional; Region: PRK15482 529507014664 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 529507014665 putative active site [active] 529507014666 HMMPfam hit to PF01380, SIS domain, score 7.2e-15 529507014667 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 529507014668 DNA-binding site [nucleotide binding]; DNA binding site 529507014669 RNA-binding motif; other site 529507014670 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 3.4e-05 529507014671 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 529507014672 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 529507014673 active site 529507014674 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 1.2e-40 529507014675 PS01129 Rlu family of pseudouridine synthase signature. 529507014676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 529507014677 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 529507014678 active site 529507014679 HMMPfam hit to PF01844, HNH endonuclease, score 9.7e-07 529507014680 PS00190 Cytochrome c family heme-binding site signature. 529507014681 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 529507014682 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 529507014683 Probable transposase; Region: OrfB_IS605; pfam01385 529507014684 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 529507014685 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507014686 HMMPfam hit to PF07282, transposase DNA-binding domai, score 5.8e-35 529507014687 HMMPfam hit to PF01385, Probable transposase, score 1.7e-117 529507014688 Transposase IS200 like; Region: Y1_Tnp; pfam01797 529507014689 HMMPfam hit to PF01797, Transposase IS200 like, score 4.4e-43 529507014690 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 529507014691 HMMPfam hit to PF05638, Protein of unknown function (DUF796), score 1.9e-87 529507014692 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 529507014693 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 529507014694 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 529507014695 HMMPfam hit to PF04524, Protein of unknown function, DUF586, score 1.1e-38 529507014696 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 529507014697 2 probable transmembrane helices predicted for PMI2993 by TMHMM2.0 at aa 693-710 and 781-803 529507014698 2 probable transmembrane helices predicted for PMI2994 by TMHMM2.0 at aa 58-80 and 153-175 529507014699 PS00017 ATP/GTP-binding site motif A (P-loop). 529507014700 PAAR motif; Region: PAAR_motif; pfam05488 529507014701 HMMPfam hit to PF05488, PAAR motif, score 0.99 529507014702 HMMPfam hit to PF05488, PAAR motif, score 7.4e-05 529507014703 Signal peptide predicted for PMI2996 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.963 between residues 32 and 33 529507014704 fimbrial operon 14 529507014705 1 probable transmembrane helix predicted for PMI2997 by TMHMM2.0 at aa 5-27 529507014706 Signal peptide predicted for PMI2997 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.730 between residues 24 and 25 529507014707 Signal peptide predicted for PMI2998 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 25 and 26 529507014708 This CDS appears to have a frameshift mutation around codon 106. The frameshift occurs within a (A)7 polymeric tract; fimbrial outer membrane usher protein (pseudogene) 529507014709 PS00163 Fumarate lyases signature. 529507014710 Signal peptide predicted for PMI3000 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.980 between residues 21 and 22 529507014711 Signal peptide predicted for PMI3001 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.642 between residues 21 and 22 529507014712 Signal peptide predicted for PMI3002 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.708 between residues 25 and 26 529507014713 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 529507014714 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507014715 non-specific DNA binding site [nucleotide binding]; other site 529507014716 salt bridge; other site 529507014717 sequence-specific DNA binding site [nucleotide binding]; other site 529507014718 HMMPfam hit to PF01381, Helix-turn-helix, score 2.1e-11 529507014719 Virulence protein [General function prediction only]; Region: COG3943 529507014720 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 529507014721 oligopeptidase A; Provisional; Region: PRK10911 529507014722 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 529507014723 active site 529507014724 Zn binding site [ion binding]; other site 529507014725 HMMPfam hit to PF01432, Peptidase family M3, score 9.7e-229 529507014726 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 529507014727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507014728 S-adenosylmethionine binding site [chemical binding]; other site 529507014729 HMMPfam hit to PF04445, Protein of unknown function (DUF548), score 2.5e-162 529507014730 short chain dehydrogenase; Provisional; Region: PRK06841 529507014731 classical (c) SDRs; Region: SDR_c; cd05233 529507014732 NAD(P) binding site [chemical binding]; other site 529507014733 active site 529507014734 HMMPfam hit to PF00106, short chain dehydrogenase, score 7.5e-78 529507014735 PS00061 Short-chain dehydrogenases/reductases family signature. 529507014736 1 probable transmembrane helix predicted for PMI3007 by TMHMM2.0 at aa 13-32 529507014737 glutamate dehydrogenase; Provisional; Region: PRK09414 529507014738 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 529507014739 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 529507014740 NAD(P) binding site [chemical binding]; other site 529507014741 HMMPfam hit to PF00208, Glutamate/Leucine/Phenylalanine/Valin, score 1.4e-134 529507014742 HMMPfam hit to PF02812, Glu/Leu/Phe/Val dehydrogenase, dimeri, score 1.9e-83 529507014743 PS00074 Glu / Leu / Phe / Val dehydrogenases active site. 529507014744 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 529507014745 Ligand Binding Site [chemical binding]; other site 529507014746 HMMPfam hit to PF00582, Universal stress protein family, score 5.6e-17 529507014747 universal stress protein UspB; Provisional; Region: PRK04960 529507014748 2 probable transmembrane helices predicted for PMI3010 by TMHMM2.0 at aa 5-24 and 90-109 529507014749 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 529507014750 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 529507014751 10 probable transmembrane helices predicted for PMI3011 by TMHMM2.0 at aa 23-45, 65-87, 107-129, 136-158, 168-190, 220-237, 247-269, 393-412, 427-449 and 483-505 529507014752 HMMPfam hit to PF01384, Phosphate transporter family, score 1.4e-105 529507014753 Predicted flavoproteins [General function prediction only]; Region: COG2081 529507014754 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 529507014755 Signal peptide predicted for PMI3012 by SignalP 2.0 HMM (Signal peptide probability 0.969) with cleavage site probability 0.500 between residues 25 and 26 529507014756 1 probable transmembrane helix predicted for PMI3012 by TMHMM2.0 at aa 10-32 529507014757 HMMPfam hit to PF03486, HI0933-like protein, score 7e-180 529507014758 2 probable transmembrane helices predicted for PMI3013 by TMHMM2.0 at aa 21-41 and 56-78 529507014759 Pirin-related protein [General function prediction only]; Region: COG1741 529507014760 Pirin; Region: Pirin; pfam02678 529507014761 HMMPfam hit to PF02678, Pirin, score 3.1e-61 529507014762 HMMPfam hit to PF07883, Cupin domain, score 0.0021 529507014763 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 529507014764 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 529507014765 active site 529507014766 substrate-binding site [chemical binding]; other site 529507014767 metal-binding site [ion binding] 529507014768 ATP binding site [chemical binding]; other site 529507014769 HMMPfam hit to PF01293, Phosphoenolpyruvate carboxykinase, score 0 529507014770 PS00532 Phosphoenolpyruvate carboxykinase (ATP) signature. 529507014771 PS00017 ATP/GTP-binding site motif A (P-loop). 529507014772 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 529507014773 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 529507014774 dimerization interface [polypeptide binding]; other site 529507014775 domain crossover interface; other site 529507014776 redox-dependent activation switch; other site 529507014777 HMMPfam hit to PF01430, Hsp33 protein, score 3.2e-119 529507014778 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 529507014779 RNA binding surface [nucleotide binding]; other site 529507014780 HMMPfam hit to PF01479, S4 domain, score 1.3e-12 529507014781 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 529507014782 HMMPfam hit to PF07095, Intracellular growth attenuator protein IgaA, score 0 529507014783 5 probable transmembrane helices predicted for PMI3018 by TMHMM2.0 at aa 5-24, 203-222, 226-248, 342-364 and 654-676 529507014784 Signal peptide predicted for PMI3018 by SignalP 2.0 HMM (Signal peptide probability 0.977) with cleavage site probability 0.776 between residues 19 and 20 529507014785 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 529507014786 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 529507014787 ADP-ribose binding site [chemical binding]; other site 529507014788 dimer interface [polypeptide binding]; other site 529507014789 active site 529507014790 nudix motif; other site 529507014791 metal binding site [ion binding]; metal-binding site 529507014792 HMMPfam hit to PF00293, NUDIX domain, score 6.2e-12 529507014793 PS00893 mutT domain signature. 529507014794 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 529507014795 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 529507014796 HMMPfam hit to PF03180, NLPA lipoprotein, score 2.2e-109 529507014797 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507014798 Signal peptide predicted for PMI3020 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.971 between residues 19 and 20 529507014799 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 529507014800 Transglycosylase; Region: Transgly; pfam00912 529507014801 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 529507014802 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 4.3e-25 529507014803 HMMPfam hit to PF00912, Transglycosylase, score 1.5e-89 529507014804 PS00017 ATP/GTP-binding site motif A (P-loop). 529507014805 1 probable transmembrane helix predicted for PMI3021 by TMHMM2.0 at aa 7-26 529507014806 Signal peptide predicted for PMI3021 by SignalP 2.0 HMM (Signal peptide probability 0.929) with cleavage site probability 0.328 between residues 24 and 25 529507014807 HMMPfam hit to PF05137, Fimbrial assembly protein (PilN), score 0.0024 529507014808 1 probable transmembrane helix predicted for PMI3023 by TMHMM2.0 at aa 21-43 529507014809 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507014810 Signal peptide predicted for PMI3024 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.953 between residues 43 and 44 529507014811 1 probable transmembrane helix predicted for PMI3024 by TMHMM2.0 at aa 7-29 529507014812 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 529507014813 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 529507014814 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 529507014815 Signal peptide predicted for PMI3025 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.771 between residues 23 and 24 529507014816 HMMPfam hit to PF00263, Bacterial type II and III secretion system p, score 3.4e-54 529507014817 PS00875 Bacterial type II secretion system protein D signature. 529507014818 shikimate kinase; Reviewed; Region: aroK; PRK00131 529507014819 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 529507014820 ADP binding site [chemical binding]; other site 529507014821 magnesium binding site [ion binding]; other site 529507014822 putative shikimate binding site; other site 529507014823 PS00017 ATP/GTP-binding site motif A (P-loop). 529507014824 HMMPfam hit to PF01202, Shikimate kinase, score 8.2e-79 529507014825 PS01128 Shikimate kinase signature. 529507014826 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 529507014827 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 529507014828 active site 529507014829 dimer interface [polypeptide binding]; other site 529507014830 metal binding site [ion binding]; metal-binding site 529507014831 HMMPfam hit to PF01761, 3-dehydroquinate synthase, score 4e-182 529507014832 hypothetical protein; Reviewed; Region: PRK11901 529507014833 cell division protein DamX; Validated; Region: PRK10905 529507014834 1 probable transmembrane helix predicted for PMI3028 by TMHMM2.0 at aa 50-69 529507014835 DNA adenine methylase; Provisional; Region: PRK10904 529507014836 HMMPfam hit to PF02086, D12 class N6 adenine-specific DNA met, score 5.2e-93 529507014837 PS00092 N-6 Adenine-specific DNA methylases signature. 529507014838 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 529507014839 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 529507014840 substrate binding site [chemical binding]; other site 529507014841 hexamer interface [polypeptide binding]; other site 529507014842 metal binding site [ion binding]; metal-binding site 529507014843 HMMPfam hit to PF00834, Ribulose-phosphate 3 epimerase family, score 2.3e-139 529507014844 PS01085 Ribulose-phosphate 3-epimerase family signature 1. 529507014845 PS01086 Ribulose-phosphate 3-epimerase family signature 2. 529507014846 phosphoglycolate phosphatase; Provisional; Region: PRK13222 529507014847 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 529507014848 motif II; other site 529507014849 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 3e-34 529507014850 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 529507014851 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 529507014852 active site 529507014853 HIGH motif; other site 529507014854 dimer interface [polypeptide binding]; other site 529507014855 KMSKS motif; other site 529507014856 HMMPfam hit to PF00579, tRNA synthetases class I (W and Y), score 1.6e-119 529507014857 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 529507014858 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 529507014859 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 529507014860 Probable transposase; Region: OrfB_IS605; pfam01385 529507014861 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 529507014862 HMMPfam hit to PF07282, transposase DNA-binding domai, score 2.8e-34 529507014863 HMMPfam hit to PF01385, Probable transposase, score 1.7e-131 529507014864 Transposase IS200 like; Region: Y1_Tnp; pfam01797 529507014865 HMMPfam hit to PF01797, Transposase IS200 like, score 4.4e-43 529507014866 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 529507014867 MOSC domain; Region: MOSC; pfam03473 529507014868 3-alpha domain; Region: 3-alpha; pfam03475 529507014869 HMMPfam hit to PF03475, 3-alpha domain, score 3.4e-10 529507014870 HMMPfam hit to PF03473, MOSC domain, score 8e-42 529507014871 superoxide dismutase; Provisional; Region: PRK10925 529507014872 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 529507014873 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 529507014874 HMMPfam hit to PF02777, Iron/manganese superoxide dismutases, C-term, score 2e-69 529507014875 PS00088 Manganese and iron superoxide dismutases signature. 529507014876 HMMPfam hit to PF00081, Iron/manganese superoxide dismutases, alpha-, score 4.2e-49 529507014877 acetyl-CoA synthetase; Provisional; Region: PRK00174 529507014878 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 529507014879 active site 529507014880 CoA binding site [chemical binding]; other site 529507014881 acyl-activating enzyme (AAE) consensus motif; other site 529507014882 AMP binding site [chemical binding]; other site 529507014883 acetate binding site [chemical binding]; other site 529507014884 HMMPfam hit to PF00501, AMP-binding enzyme, score 1.7e-138 529507014885 PS00455 AMP-binding domain signature. 529507014886 Predicted membrane protein [Function unknown]; Region: COG3162 529507014887 HMMPfam hit to PF04341, Protein of unknown function, DUF485, score 2.2e-47 529507014888 2 probable transmembrane helices predicted for PMI3038 by TMHMM2.0 at aa 25-47 and 62-84 529507014889 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 529507014890 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 529507014891 Na binding site [ion binding]; other site 529507014892 Signal peptide predicted for PMI3039 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.975 between residues 20 and 21 529507014893 14 probable transmembrane helices predicted for PMI3039 by TMHMM2.0 at aa 7-24, 34-56, 77-99, 104-126, 147-169, 179-201, 206-228, 265-287, 300-322, 363-385, 406-425, 430-452, 464-486 and 496-518 529507014894 HMMPfam hit to PF00474, Sodium:solute symporter family, score 2.4e-169 529507014895 PS00456 Sodium:solute symporter family signature 1. 529507014896 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 529507014897 Sulfatase; Region: Sulfatase; pfam00884 529507014898 5 probable transmembrane helices predicted for PMI3040 by TMHMM2.0 at aa 21-43, 47-64, 71-90, 124-141 and 154-173 529507014899 HMMPfam hit to PF00884, Sulfatase, score 7.5e-53 529507014900 This CDS appears to have an internal deletion and a frameshift mutation; transposase (pseudogene) 529507014901 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507014902 HMMPfam hit to PF07282, transposase DNA-binding domai, score 1.2e-19 529507014903 HMMPfam hit to PF01385, Probable transposase, score 1.9e-15 529507014904 Transposase IS200 like; Region: Y1_Tnp; pfam01797 529507014905 HMMPfam hit to PF01797, Transposase IS200 like, score 9e-42 529507014906 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507014907 Uncharacterized conserved protein [Function unknown]; Region: COG1556 529507014908 HMMPfam hit to PF02589, Uncharacterized ACR, YkgG family COG1556, score 1.8e-54 529507014909 iron-sulfur cluster-binding protein; Region: TIGR00273 529507014910 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 529507014911 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 529507014912 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 529507014913 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507014914 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.016 529507014915 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507014916 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 529507014917 Cysteine-rich domain; Region: CCG; pfam02754 529507014918 Cysteine-rich domain; Region: CCG; pfam02754 529507014919 HMMPfam hit to PF02754, Cysteine-rich domain, score 2.6e-16 529507014920 HMMPfam hit to PF02754, Cysteine-rich domain, score 1.3e-13 529507014921 Transcriptional regulators [Transcription]; Region: FadR; COG2186 529507014922 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 529507014923 DNA-binding site [nucleotide binding]; DNA binding site 529507014924 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 529507014925 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 4.1e-18 529507014926 PS00043 Bacterial regulatory proteins, gntR family signature. 529507014927 HMMPfam hit to PF07729, FCD domain, score 9.7e-23 529507014928 putative transporter; Provisional; Region: PRK10504 529507014929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507014930 putative substrate translocation pore; other site 529507014931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507014932 Signal peptide predicted for PMI3048 by SignalP 2.0 HMM (Signal peptide probability 0.957) with cleavage site probability 0.688 between residues 26 and 27 529507014933 14 probable transmembrane helices predicted for PMI3048 by TMHMM2.0 at aa 9-31, 46-68, 81-103, 107-124, 136-158, 163-182, 195-217, 221-243, 263-285, 290-312, 324-346, 356-378, 391-413 and 428-450 529507014934 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.4e-49 529507014935 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 529507014936 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 529507014937 substrate binding site [chemical binding]; other site 529507014938 dimer interface [polypeptide binding]; other site 529507014939 ATP binding site [chemical binding]; other site 529507014940 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 5.1e-85 529507014941 PS00584 pfkB family of carbohydrate kinases signature 2. 529507014942 PS00583 pfkB family of carbohydrate kinases signature 1. 529507014943 regulatory ATPase RavA; Provisional; Region: PRK13531 529507014944 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 529507014945 Walker A motif; other site 529507014946 ATP binding site [chemical binding]; other site 529507014947 Walker B motif; other site 529507014948 arginine finger; other site 529507014949 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 529507014950 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 8.8e-55 529507014951 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 529507014952 hypothetical protein; Provisional; Region: yieM; PRK10997 529507014953 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 529507014954 metal ion-dependent adhesion site (MIDAS); other site 529507014955 asparagine synthetase AsnA; Provisional; Region: PRK05425 529507014956 motif 1; other site 529507014957 dimer interface [polypeptide binding]; other site 529507014958 active site 529507014959 motif 2; other site 529507014960 motif 3; other site 529507014961 HMMPfam hit to PF03590, Aspartate-ammonia ligase, score 5.3e-170 529507014962 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 529507014963 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 529507014964 putative DNA binding site [nucleotide binding]; other site 529507014965 putative Zn2+ binding site [ion binding]; other site 529507014966 AsnC family; Region: AsnC_trans_reg; pfam01037 529507014967 PS00519 Bacterial regulatory proteins, asnC family signature. 529507014968 HMMPfam hit to PF01037, AsnC family, score 1.2e-19 529507014969 origin of replication ttatccaca 529507014970 FMN-binding protein MioC; Provisional; Region: PRK09004 529507014971 HMMPfam hit to PF00258, Flavodoxin, score 9e-38 529507014972 origin of replication ttatccaca 529507014973 origin of replication ttatccaca 529507014974 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 529507014975 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 529507014976 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 529507014977 HMMPfam hit to PF01134, Glucose inhibited division protein A, score 4.6e-270 529507014978 PS01280 Glucose inhibited division protein A family signature 1. 529507014979 PS01281 Glucose inhibited division protein A family signature 2. 529507014980 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 529507014981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507014982 S-adenosylmethionine binding site [chemical binding]; other site 529507014983 HMMPfam hit to PF02527, Glucose inhibited division protein, score 2.1e-76 529507014984 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 529507014985 HMMPfam hit to PF03899, ATP synthase I chain, score 4.3e-16 529507014986 4 probable transmembrane helices predicted for PMI3057 by TMHMM2.0 at aa 12-31, 36-58, 75-97 and 101-123 529507014987 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 529507014988 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 529507014989 5 probable transmembrane helices predicted for PMI3058 by TMHMM2.0 at aa 41-63, 103-125, 145-167, 214-236 and 246-268 529507014990 HMMPfam hit to PF00119, ATP synthase A chain, score 2e-67 529507014991 PS00449 ATP synthase a subunit signature. 529507014992 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 529507014993 Signal peptide predicted for PMI3059 by SignalP 2.0 HMM (Signal peptide probability 0.758) with cleavage site probability 0.534 between residues 23 and 24 529507014994 HMMPfam hit to PF00137, ATP synthase subunit C, score 5.9e-25 529507014995 2 probable transmembrane helices predicted for PMI3059 by TMHMM2.0 at aa 10-32 and 53-75 529507014996 PS00605 ATP synthase c subunit signature. 529507014997 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 529507014998 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 529507014999 Signal peptide predicted for PMI3060 by SignalP 2.0 HMM (Signal peptide probability 0.722) with cleavage site probability 0.625 between residues 31 and 32 529507015000 1 probable transmembrane helix predicted for PMI3060 by TMHMM2.0 at aa 5-27 529507015001 HMMPfam hit to PF00430, ATP synthase B/B' CF(0), score 9.7e-38 529507015002 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 529507015003 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 529507015004 HMMPfam hit to PF00213, ATP synthase delta (OSCP) subunit, score 3.8e-66 529507015005 PS00389 ATP synthase delta (OSCP) subunit signature. 529507015006 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 529507015007 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 529507015008 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 529507015009 beta subunit interaction interface [polypeptide binding]; other site 529507015010 Walker A motif; other site 529507015011 ATP binding site [chemical binding]; other site 529507015012 Walker B motif; other site 529507015013 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 529507015014 HMMPfam hit to PF02874, ATP synthase alpha/beta family, beta-ba, score 2.3e-16 529507015015 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleot, score 8.4e-112 529507015016 PS00017 ATP/GTP-binding site motif A (P-loop). 529507015017 PS00152 ATP synthase alpha and beta subunits signature. 529507015018 HMMPfam hit to PF00306, ATP synthase alpha/beta chain, C termin, score 2.5e-27 529507015019 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 529507015020 core domain interface [polypeptide binding]; other site 529507015021 delta subunit interface [polypeptide binding]; other site 529507015022 epsilon subunit interface [polypeptide binding]; other site 529507015023 HMMPfam hit to PF00231, ATP synthase, score 4.7e-167 529507015024 PS00041 Bacterial regulatory proteins, araC family signature. 529507015025 PS00153 ATP synthase gamma subunit signature. 529507015026 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 529507015027 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 529507015028 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 529507015029 alpha subunit interaction interface [polypeptide binding]; other site 529507015030 Walker A motif; other site 529507015031 ATP binding site [chemical binding]; other site 529507015032 Walker B motif; other site 529507015033 inhibitor binding site; inhibition site 529507015034 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 529507015035 HMMPfam hit to PF02874, ATP synthase alpha/beta family, beta-ba, score 8.8e-26 529507015036 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleot, score 3.8e-89 529507015037 PS00017 ATP/GTP-binding site motif A (P-loop). 529507015038 PS00152 ATP synthase alpha and beta subunits signature. 529507015039 HMMPfam hit to PF00306, ATP synthase alpha/beta chain, C termin, score 1.7e-51 529507015040 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 529507015041 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 529507015042 gamma subunit interface [polypeptide binding]; other site 529507015043 epsilon subunit interface [polypeptide binding]; other site 529507015044 LBP interface [polypeptide binding]; other site 529507015045 HMMPfam hit to PF02823, ATP synthase, Delta/Epsilon chain, beta, score 1.1e-32 529507015046 HMMPfam hit to PF00401, ATP synthase, Delta/Epsilon chain, long, score 3.3e-11 529507015047 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 529507015048 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 529507015049 Substrate binding site; other site 529507015050 Mg++ binding site; other site 529507015051 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 529507015052 active site 529507015053 substrate binding site [chemical binding]; other site 529507015054 CoA binding site [chemical binding]; other site 529507015055 HMMPfam hit to PF00483, Nucleotidyl transferase, score 1.4e-07 529507015056 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 0.26 529507015057 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 0.0048 529507015058 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 29 529507015059 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 12 529507015060 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 7 529507015061 PS00101 Hexapeptide-repeat containing-transferases signature. 529507015062 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 23 529507015063 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 529507015064 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 529507015065 glutaminase active site [active] 529507015066 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 529507015067 dimer interface [polypeptide binding]; other site 529507015068 active site 529507015069 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 529507015070 dimer interface [polypeptide binding]; other site 529507015071 active site 529507015072 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 6.8e-51 529507015073 HMMPfam hit to PF01380, SIS domain, score 6.8e-37 529507015074 HMMPfam hit to PF01380, SIS domain, score 2.4e-33 529507015075 This CDS contains an in-frame stop codon; ABC transporter, ATP-binding protein (pseudogene) 529507015076 PS00017 ATP/GTP-binding site motif A (P-loop). 529507015077 HMMPfam hit to PF00005, ABC transporter, score 8.6e-07 529507015078 PS00211 ABC transporters family signature. 529507015079 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 529507015080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507015081 dimer interface [polypeptide binding]; other site 529507015082 conserved gate region; other site 529507015083 putative PBP binding loops; other site 529507015084 ABC-ATPase subunit interface; other site 529507015085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507015086 dimer interface [polypeptide binding]; other site 529507015087 conserved gate region; other site 529507015088 putative PBP binding loops; other site 529507015089 ABC-ATPase subunit interface; other site 529507015090 12 probable transmembrane helices predicted for PMI3070 by TMHMM2.0 at aa 20-42, 74-96, 109-131, 146-168, 204-226, 246-268, 296-318, 350-372, 385-407, 417-439, 486-508 and 523-545 529507015091 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.3e-08 529507015092 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 9.7e-06 529507015093 putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261 529507015094 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 529507015095 Signal peptide predicted for PMI3071 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22 529507015096 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 5.3e-12 529507015097 hydroxyglutarate oxidase; Provisional; Region: PRK11728 529507015098 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 529507015099 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 8.2e-30 529507015100 Transposase IS200 like; Region: Y1_Tnp; pfam01797 529507015101 HMMPfam hit to PF01797, Transposase IS200 like, score 4.4e-43 529507015102 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507015103 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 529507015104 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 529507015105 Probable transposase; Region: OrfB_IS605; pfam01385 529507015106 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 529507015107 HMMPfam hit to PF01385, Probable transposase, score 6.5e-129 529507015108 HMMPfam hit to PF07282, transposase DNA-binding domai, score 3e-34 529507015109 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 529507015110 HMMPfam hit to PF06836, Protein of unknown function (DUF1240), score 1.7e-28 529507015111 3 probable transmembrane helices predicted for PMI3075 by TMHMM2.0 at aa 9-31, 46-68 and 80-102 529507015112 Signal peptide predicted for PMI3075 by SignalP 2.0 HMM (Signal peptide probability 0.666) with cleavage site probability 0.651 between residues 53 and 54 529507015113 Also similar to the upstream CDS PMI3078; truncated at N-tertminus relative to database matches; membrane protein (fragment) 529507015114 membrane protein (pseudogene);This CDS contains a frameshift mutation; Also similar to the downstream CDS PMI3075 529507015115 PS00327 Bacterial rhodopsins retinal binding site. 529507015116 Signal peptide predicted for PMI3076 by SignalP 2.0 HMM (Signal peptide probability 0.906) with cleavage site probability 0.418 between residues 28 and 29 529507015117 1 probable transmembrane helix predicted for PMI3076 by TMHMM2.0 at aa 5-27 529507015118 2 probable transmembrane helices predicted for PMI3077 by TMHMM2.0 at aa 13-35 and 45-67 529507015119 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 529507015120 3 probable transmembrane helices predicted for PMI3078 by TMHMM2.0 at aa 7-26, 49-66 and 73-90 529507015121 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 529507015122 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 529507015123 motif II; other site 529507015124 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 4.3e-18 529507015125 glutamate carboxypeptidase; Reviewed; Region: PRK06133 529507015126 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 529507015127 metal binding site [ion binding]; metal-binding site 529507015128 dimer interface [polypeptide binding]; other site 529507015129 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 6.3e-25 529507015130 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 2.6e-25 529507015131 Predicted membrane protein [Function unknown]; Region: COG1288 529507015132 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 529507015133 Signal peptide predicted for PMI3081 by SignalP 2.0 HMM (Signal peptide probability 0.693) with cleavage site probability 0.250 between residues 25 and 26 529507015134 HMMPfam hit to PF03606, C4-dicarboxylate anaerobic carrier, score 1e-61 529507015135 10 probable transmembrane helices predicted for PMI3081 by TMHMM2.0 at aa 15-37, 72-94, 117-139, 160-182, 197-219, 259-276, 281-303, 363-385, 412-434 and 441-463 529507015136 tetracycline repressor protein TetR; Provisional; Region: PRK13756 529507015137 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 529507015138 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 529507015139 HMMPfam hit to PF02909, Tetracyclin repressor, C-terminal all-alpha, score 3.7e-19 529507015140 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 1.9e-13 529507015141 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 529507015142 HlyD family secretion protein; Region: HlyD_3; pfam13437 529507015143 1 probable transmembrane helix predicted for PMI3083 by TMHMM2.0 at aa 13-35 529507015144 HMMPfam hit to PF00529, HlyD family secretion protein, score 3.2e-19 529507015145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507015146 putative substrate translocation pore; other site 529507015147 Signal peptide predicted for PMI3084 by SignalP 2.0 HMM (Signal peptide probability 0.802) with cleavage site probability 0.655 between residues 39 and 40 529507015148 14 probable transmembrane helices predicted for PMI3084 by TMHMM2.0 at aa 13-35, 55-77, 84-106, 110-132, 139-158, 173-195, 208-227, 237-259, 279-301, 311-333, 340-359, 369-391, 403-425 and 469-491 529507015149 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.3e-15 529507015150 Protein of unknown function, DUF; Region: DUF411; cl01142 529507015151 HMMPfam hit to PF04214, Protein of unknown function, DUF, score 3.6e-09 529507015152 Signal peptide predicted for PMI3085 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 22 and 23 529507015153 fimbrial operon 15 529507015154 putative fimbrial chaperone protein; Provisional; Region: PRK09918 529507015155 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 529507015156 Signal peptide predicted for PMI3086 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.962 between residues 20 and 21 529507015157 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 529507015158 This CDS appears to have a frameshift mutation around codon 102. The frameshift occurs within a (A)9 polymeric tract; outer membrane fimbrial usher protein (pseudogene) 529507015159 HMMPfam hit to PF00577, Fimbrial Usher protein, score 2e-10 529507015160 Signal peptide predicted for PMI3088 by SignalP 2.0 HMM (Signal peptide probability 0.985) with cleavage site probability 0.960 between residues 28 and 29 529507015161 Signal peptide predicted for PMI3089 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 25 and 26 529507015162 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 529507015163 Signal peptide predicted for PMI3090 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22 529507015164 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 529507015165 Signal peptide predicted for PMI3091 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22 529507015166 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 529507015167 HMMPfam hit to PF06551, Protein of unknown function (DUF1120), score 1.4e-09 529507015168 PS00017 ATP/GTP-binding site motif A (P-loop). 529507015169 Signal peptide predicted for PMI3092 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 21 and 22 529507015170 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 529507015171 HMMPfam hit to PF04076, Domain unknown function (DUF388), score 5.1e-44 529507015172 Signal peptide predicted for PMI3093 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.503 between residues 19 and 20 529507015173 Rhomboid family; Region: Rhomboid; cl11446 529507015174 HMMPfam hit to PF01694, Rhomboid family, score 5.6e-14 529507015175 6 probable transmembrane helices predicted for PMI3094 by TMHMM2.0 at aa 13-35, 55-77, 84-103, 107-129, 136-158 and 162-179 529507015176 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 529507015177 fructokinase; Reviewed; Region: PRK09557 529507015178 nucleotide binding site [chemical binding]; other site 529507015179 HMMPfam hit to PF00480, ROK family, score 3.6e-53 529507015180 PS01125 ROK family signature. 529507015181 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 529507015182 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 529507015183 DXD motif; other site 529507015184 PilZ domain; Region: PilZ; pfam07238 529507015185 Signal peptide predicted for PMI3097 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.496 between residues 45 and 46 529507015186 9 probable transmembrane helices predicted for PMI3097 by TMHMM2.0 at aa 21-43, 48-63, 70-87, 102-124, 404-421, 425-447, 459-481, 504-526 and 539-561 529507015187 HMMPfam hit to PF00535, Glycosyl transferase, score 1.2e-25 529507015188 cellulose synthase regulator protein; Provisional; Region: PRK11114 529507015189 Signal peptide predicted for PMI3098 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.972 between residues 24 and 25 529507015190 2 probable transmembrane helices predicted for PMI3098 by TMHMM2.0 at aa 7-29 and 742-764 529507015191 HMMPfam hit to PF03170, Bacterial cellulose synthase subunit, score 3.5e-48 529507015192 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 529507015193 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 529507015194 Signal peptide predicted for PMI3099 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.655 between residues 29 and 30 529507015195 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 3.3 529507015196 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 2.5 529507015197 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 2 529507015198 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 1.5 529507015199 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 1.9 529507015200 HMMPfam hit to PF05420, Cellulose synthase operon protein C C-termin, score 2.7e-66 529507015201 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 529507015202 PAS domain; Region: PAS_9; pfam13426 529507015203 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 529507015204 putative active site [active] 529507015205 heme pocket [chemical binding]; other site 529507015206 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 529507015207 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 529507015208 metal binding site [ion binding]; metal-binding site 529507015209 active site 529507015210 I-site; other site 529507015211 HMMPfam hit to PF00990, GGDEF domain, score 1.9e-44 529507015212 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 529507015213 active site 529507015214 tetramer interface; other site 529507015215 HMMPfam hit to PF00483, Nucleotidyl transferase, score 1.4e-10 529507015216 PS00017 ATP/GTP-binding site motif A (P-loop). 529507015217 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 529507015218 Signal peptide predicted for PMI3103 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 31 and 32 529507015219 HMMPfam hit to PF01270, Glycosyl hydrolases family, score 9e-104 529507015220 1 probable transmembrane helix predicted for PMI3103 by TMHMM2.0 at aa 13-32 529507015221 PS00812 Glycosyl hydrolases family 8 signature. 529507015222 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 529507015223 Sulfatase; Region: Sulfatase; cl17466 529507015224 5 probable transmembrane helices predicted for PMI3104 by TMHMM2.0 at aa 5-22, 26-48, 53-72, 101-123 and 135-152 529507015225 Signal peptide predicted for PMI3104 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.783 between residues 55 and 56 529507015226 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 529507015227 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 529507015228 G1 box; other site 529507015229 putative GEF interaction site [polypeptide binding]; other site 529507015230 GTP/Mg2+ binding site [chemical binding]; other site 529507015231 Switch I region; other site 529507015232 G2 box; other site 529507015233 G3 box; other site 529507015234 Switch II region; other site 529507015235 G4 box; other site 529507015236 G5 box; other site 529507015237 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 529507015238 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 529507015239 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 529507015240 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 529507015241 HMMPfam hit to PF03144, Elongation factor Tu domain, score 5.6e-09 529507015242 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 3.2e-32 529507015243 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507015244 PS00017 ATP/GTP-binding site motif A (P-loop). 529507015245 selenocysteine synthase; Provisional; Region: PRK04311 529507015246 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 529507015247 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 529507015248 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 529507015249 catalytic residue [active] 529507015250 HMMPfam hit to PF03841, L-seryl-tRNA selenium transferase, score 1e-224 529507015251 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 529507015252 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 529507015253 HMMPfam hit to PF04216, Protein involved in formate dehydrogenase fo, score 9.4e-155 529507015254 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 529507015255 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 529507015256 4 probable transmembrane helices predicted for PMI3108 by TMHMM2.0 at aa 20-42, 57-75, 116-138 and 153-175 529507015257 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 529507015258 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 529507015259 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 2.3e-05 529507015260 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507015261 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 529507015262 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 529507015263 [4Fe-4S] binding site [ion binding]; other site 529507015264 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 529507015265 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 529507015266 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 529507015267 molybdopterin cofactor binding site; other site 529507015268 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 9.5e-41 529507015269 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 529507015270 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 9e-07 529507015271 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 dom, score 1.9e-22 529507015272 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 529507015273 Signal peptide predicted for PMI3111 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.708 between residues 33 and 34 529507015274 1 probable transmembrane helix predicted for PMI3111 by TMHMM2.0 at aa 17-39 529507015275 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 529507015276 HMMPfam hit to PF02634, FdhD/NarQ family, score 1.1e-108 529507015277 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 529507015278 Coenzyme A binding pocket [chemical binding]; other site 529507015279 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 529507015280 Signal peptide predicted for PMI3115 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.994 between residues 23 and 24 529507015281 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507015282 Predicted amidohydrolase [General function prediction only]; Region: COG0388 529507015283 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585 529507015284 putative active site [active] 529507015285 catalytic triad [active] 529507015286 putative dimer interface [polypeptide binding]; other site 529507015287 HMMPfam hit to PF00795, Carbon-nitrogen hydrolase, score 1.2e-34 529507015288 Transcriptional regulator [Transcription]; Region: LysR; COG0583 529507015289 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507015290 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 529507015291 dimerization interface [polypeptide binding]; other site 529507015292 substrate binding pocket [chemical binding]; other site 529507015293 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.6e-19 529507015294 PS00044 Bacterial regulatory proteins, lysR family signature. 529507015295 HMMPfam hit to PF03466, LysR substrate binding domain, score 4e-17 529507015296 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 529507015297 Signal peptide predicted for PMI3118 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.751 between residues 20 and 21 529507015298 Protein of unknown function (DUF560); Region: DUF560; pfam04575 529507015299 Signal peptide predicted for PMI3119 by SignalP 2.0 HMM (Signal peptide probability 0.933) with cleavage site probability 0.457 between residues 24 and 25 529507015300 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 529507015301 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 529507015302 Signal peptide predicted for PMI3120 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.976 between residues 27 and 28 529507015303 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 1.2e-07 529507015304 HMMPfam hit to PF00593, TonB dependent receptor, score 1.1e-24 529507015305 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS01156 TonB-dependent receptor proteins signature 2. 529507015306 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 529507015307 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 529507015308 1 probable transmembrane helix predicted for PMI3121 by TMHMM2.0 at aa 12-31 529507015309 HMMPfam hit to PF03544, Gram-negative bacterial tonB protein, score 6.9e-08 529507015310 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 529507015311 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 529507015312 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 529507015313 active site 529507015314 metal binding site [ion binding]; metal-binding site 529507015315 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 6.6e-08 529507015316 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 529507015317 HMMPfam hit to PF06496, Protein of unknown function (DUF1097), score 3e-64 529507015318 5 probable transmembrane helices predicted for PMI3124 by TMHMM2.0 at aa 12-34, 49-71, 78-96, 100-117 and 124-146 529507015319 Signal peptide predicted for PMI3124 by SignalP 2.0 HMM (Signal peptide probability 0.981) with cleavage site probability 0.435 between residues 41 and 42 529507015320 HipA N-terminal domain; Region: Couple_hipA; pfam13657 529507015321 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 529507015322 HipA-like N-terminal domain; Region: HipA_N; pfam07805 529507015323 HipA-like C-terminal domain; Region: HipA_C; pfam07804 529507015324 HMMPfam hit to PF07804, HipA-like C-terminal domain, score 1.9e-37 529507015325 HMMPfam hit to PF07805, HipA-like N-terminal domain, score 2.4e-21 529507015326 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507015327 non-specific DNA binding site [nucleotide binding]; other site 529507015328 salt bridge; other site 529507015329 sequence-specific DNA binding site [nucleotide binding]; other site 529507015330 HMMPfam hit to PF01381, Helix-turn-helix, score 5.6e-09 529507015331 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 529507015332 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 529507015333 trmE is a tRNA modification GTPase; Region: trmE; cd04164 529507015334 G1 box; other site 529507015335 GTP/Mg2+ binding site [chemical binding]; other site 529507015336 Switch I region; other site 529507015337 G2 box; other site 529507015338 Switch II region; other site 529507015339 G3 box; other site 529507015340 G4 box; other site 529507015341 G5 box; other site 529507015342 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 529507015343 HMMPfam hit to PF01926, GTPase of unknown function, score 4.9e-41 529507015344 PS00017 ATP/GTP-binding site motif A (P-loop). 529507015345 membrane protein insertase; Provisional; Region: PRK01318 529507015346 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 529507015347 HMMPfam hit to PF02096, 60Kd inner membrane protein, score 1.4e-118 529507015348 3 probable transmembrane helices predicted for PMI3128 by TMHMM2.0 at aa 307-329, 376-398 and 454-476 529507015349 PS00496 P-II protein urydylation site. 529507015350 Haemolytic domain; Region: Haemolytic; pfam01809 529507015351 HMMPfam hit to PF01809, Domain of unknown function DUF37, score 5.9e-43 529507015352 ribonuclease P; Reviewed; Region: rnpA; PRK01732 529507015353 HMMPfam hit to PF00825, Ribonuclease P, score 8.5e-60 529507015354 PS00648 Bacterial ribonuclease P protein component signature. 529507015355 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 529507015356 HMMPfam hit to PF00468, Ribosomal protein L34, score 9.8e-22 529507015357 PS00784 Ribosomal protein L34 signature. 529507015358 DnaA N-terminal domain; Region: DnaA_N; pfam11638 529507015359 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 529507015360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 529507015361 Walker A motif; other site 529507015362 ATP binding site [chemical binding]; other site 529507015363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 529507015364 Walker B motif; other site 529507015365 arginine finger; other site 529507015366 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 529507015367 DnaA box-binding interface [nucleotide binding]; other site 529507015368 HMMPfam hit to PF00308, Bacterial dnaA protein, score 4e-217 529507015369 PS00017 ATP/GTP-binding site motif A (P-loop). 529507015370 PS01008 DnaA protein signature. 529507015371 DNA polymerase III subunit beta; Validated; Region: PRK05643 529507015372 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 529507015373 putative DNA binding surface [nucleotide binding]; other site 529507015374 dimer interface [polypeptide binding]; other site 529507015375 beta-clamp/clamp loader binding surface; other site 529507015376 beta-clamp/translesion DNA polymerase binding surface; other site 529507015377 HMMPfam hit to PF00712, DNA polymerase III beta subunit, N-te, score 2.3e-66 529507015378 HMMPfam hit to PF02767, DNA polymerase III beta subunit, cent, score 1.5e-66 529507015379 HMMPfam hit to PF02768, DNA polymerase III beta subunit, C-te, score 1.2e-63 529507015380 recF protein; Region: recf; TIGR00611 529507015381 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507015382 Walker A/P-loop; other site 529507015383 ATP binding site [chemical binding]; other site 529507015384 Q-loop/lid; other site 529507015385 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507015386 ABC transporter signature motif; other site 529507015387 Walker B; other site 529507015388 D-loop; other site 529507015389 H-loop/switch region; other site 529507015390 HMMPfam hit to PF02463, RecF/RecN/SMC N terminal domain, score 3.4e-158 529507015391 PS00017 ATP/GTP-binding site motif A (P-loop). 529507015392 PS00617 RecF protein signature 1. 529507015393 PS00618 RecF protein signature 2. 529507015394 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 529507015395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 529507015396 ATP binding site [chemical binding]; other site 529507015397 Mg2+ binding site [ion binding]; other site 529507015398 G-X-G motif; other site 529507015399 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 529507015400 anchoring element; other site 529507015401 dimer interface [polypeptide binding]; other site 529507015402 ATP binding site [chemical binding]; other site 529507015403 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 529507015404 active site 529507015405 putative metal-binding site [ion binding]; other site 529507015406 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 529507015407 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and H, score 2.4e-33 529507015408 HMMPfam hit to PF00204, DNA gyrase B, score 5.3e-92 529507015409 HMMPfam hit to PF01751, Toprim domain, score 9.1e-05 529507015410 PS00177 DNA topoisomerase II signature. 529507015411 HMMPfam hit to PF00986, DNA gyrase B subunit, carboxyl terminus, score 4.3e-45 529507015412 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 529507015413 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 529507015414 HMMPfam hit to PF02774, Semialdehyde dehydrogenase, dimerisat, score 1e-80 529507015415 PS01103 Aspartate-semialdehyde dehydrogenase signature. 529507015416 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD bindi, score 3.8e-43 529507015417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507015418 S-adenosylmethionine binding site [chemical binding]; other site 529507015419 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 529507015420 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 529507015421 putative active site [active] 529507015422 HMMPfam hit to PF01380, SIS domain, score 0.0014 529507015423 PS01272 Glucokinase regulatory protein family signature. 529507015424 mobile element 529507015425 possible frameshift at N-terminus; transposase (pseudogene) 529507015426 Restriction endonuclease; Region: Mrr_cat; pfam04471 529507015427 HMMPfam hit to PF04471, Restriction endonuclease, score 2.7e-15 529507015428 PS00092 N-6 Adenine-specific DNA methylases signature. 529507015429 DNA methylase; Region: N6_N4_Mtase; pfam01555 529507015430 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 529507015431 DNA methylase; Region: N6_N4_Mtase; cl17433 529507015432 PS00017 ATP/GTP-binding site motif A (P-loop). 529507015433 PS00092 N-6 Adenine-specific DNA methylases signature. 529507015434 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 529507015435 PS00092 N-6 Adenine-specific DNA methylases signature. 529507015436 HMMPfam hit to PF02086, D12 class N6 adenine-specific DNA met, score 0.00019 529507015437 Helix-turn-helix domain; Region: HTH_17; pfam12728 529507015438 Helix-turn-helix domain; Region: HTH_28; pfam13518 529507015439 Winged helix-turn helix; Region: HTH_29; pfam13551 529507015440 Integrase core domain; Region: rve; pfam00665 529507015441 Integrase core domain; Region: rve_3; pfam13683 529507015442 HMMPfam hit to PF00665, Integrase core domain, score 2.2e-28 529507015443 transposase (fragment) 529507015444 integrase (fragment) 529507015445 hypothetical protein; Provisional; Region: PRK11820 529507015446 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 529507015447 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 529507015448 HMMPfam hit to PF03755, YicC-like family, N-terminal region, score 2e-73 529507015449 ribonuclease PH; Reviewed; Region: rph; PRK00173 529507015450 Ribonuclease PH; Region: RNase_PH_bact; cd11362 529507015451 hexamer interface [polypeptide binding]; other site 529507015452 active site 529507015453 HMMPfam hit to PF01138, 3' exoribonuclease family, domain, score 1.8e-54 529507015454 PS01277 Ribonuclease PH signature. 529507015455 HMMPfam hit to PF03725, 3' exoribonuclease family, domain, score 2.3e-21 529507015456 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 529507015457 active site 529507015458 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 9e-29 529507015459 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 529507015460 division inhibitor protein; Provisional; Region: slmA; PRK09480 529507015461 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 529507015462 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 1.5e-08 529507015463 PS01081 Bacterial regulatory proteins, tetR family signature. 529507015464 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 529507015465 trimer interface [polypeptide binding]; other site 529507015466 active site 529507015467 HMMPfam hit to PF00692, dUTPase, score 6.5e-51 529507015468 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 529507015469 Flavoprotein; Region: Flavoprotein; pfam02441 529507015470 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 529507015471 HMMPfam hit to PF04127, DNA / pantothenate metabolism flavoprote, score 2.4e-42 529507015472 HMMPfam hit to PF02441, Flavoprotein, score 6.5e-45 529507015473 hypothetical protein; Reviewed; Region: PRK00024 529507015474 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 529507015475 MPN+ (JAMM) motif; other site 529507015476 Zinc-binding site [ion binding]; other site 529507015477 HMMPfam hit to PF04002, RadC, DNA repair protein, score 1.7e-70 529507015478 PS01302 DNA repair protein radC family signature. 529507015479 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 529507015480 HMMPfam hit to PF00830, Ribosomal L28 family, score 6.8e-36 529507015481 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 529507015482 HMMPfam hit to PF00471, Ribosomal protein L33, score 4e-23 529507015483 PS00582 Ribosomal protein L33 signature. 529507015484 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 529507015485 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 529507015486 HMMPfam hit to PF00534, Glycosyl transferases group, score 1.9e-42 529507015487 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 529507015488 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 529507015489 putative active site [active] 529507015490 HMMPfam hit to PF01075, Glycosyltransferase family, score 1.8e-07 529507015491 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 529507015492 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 529507015493 HMMPfam hit to PF00534, Glycosyl transferases group, score 4.6e-46 529507015494 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 529507015495 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 529507015496 HMMPfam hit to PF00534, Glycosyl transferases group, score 4.6e-17 529507015497 O-antigen ligase RfaL; Provisional; Region: PRK15487 529507015498 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 529507015499 12 probable transmembrane helices predicted for PMI3163 by TMHMM2.0 at aa 12-31, 36-50, 63-85, 95-112, 125-144, 164-181, 186-205, 209-226, 231-250, 327-349, 362-384 and 388-407 529507015500 HMMPfam hit to PF04932, O-Antigen Polymerase, score 3.7e-13 529507015501 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 529507015502 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 529507015503 DNA binding site [nucleotide binding] 529507015504 catalytic residue [active] 529507015505 H2TH interface [polypeptide binding]; other site 529507015506 putative catalytic residues [active] 529507015507 turnover-facilitating residue; other site 529507015508 intercalation triad [nucleotide binding]; other site 529507015509 8OG recognition residue [nucleotide binding]; other site 529507015510 putative reading head residues; other site 529507015511 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 529507015512 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 529507015513 HMMPfam hit to PF01149, Formamidopyrimidine-DNA glycosylase N-, score 1.9e-51 529507015514 HMMPfam hit to PF06831, Formamidopyrimidine-DNA glycosylase H2, score 3.3e-46 529507015515 HMMPfam hit to PF06827, Zinc finger found in FPG and IleRS, score 7.2e-07 529507015516 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 529507015517 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 529507015518 active site 529507015519 (T/H)XGH motif; other site 529507015520 HMMPfam hit to PF01467, Cytidylyltransferase, score 1.4e-30 529507015521 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 529507015522 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 529507015523 putative metal binding site; other site 529507015524 HMMPfam hit to PF00535, Glycosyl transferase, score 2.4e-20 529507015525 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 529507015526 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 529507015527 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 529507015528 HMMPfam hit to PF00534, Glycosyl transferases group, score 6.4e-05 529507015529 HMMPfam hit to PF04413, 3-Deoxy-D-manno-octulosonic-acid tran, score 1.8e-105 529507015530 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 529507015531 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 529507015532 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 529507015533 putative active site [active] 529507015534 HMMPfam hit to PF01075, Glycosyltransferase family, score 6.7e-49 529507015535 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 529507015536 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 529507015537 HMMPfam hit to PF00534, Glycosyl transferases group, score 4.9e-28 529507015538 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 529507015539 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 529507015540 putative ADP-binding pocket [chemical binding]; other site 529507015541 HMMPfam hit to PF00534, Glycosyl transferases group, score 8.7e-22 529507015542 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 529507015543 putative active site [active] 529507015544 putative catalytic site [active] 529507015545 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 529507015546 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 529507015547 putative active site [active] 529507015548 HMMPfam hit to PF01075, Glycosyltransferase family, score 7.4e-08 529507015549 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 529507015550 active site 529507015551 HMMPfam hit to PF00535, Glycosyl transferase, score 1.9e-20 529507015552 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 529507015553 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 529507015554 putative active site [active] 529507015555 HMMPfam hit to PF01075, Glycosyltransferase family, score 2.5e-91 529507015556 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 529507015557 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 529507015558 putative active site [active] 529507015559 HMMPfam hit to PF01075, Glycosyltransferase family, score 2e-107 529507015560 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 529507015561 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 529507015562 NADP binding site [chemical binding]; other site 529507015563 homopentamer interface [polypeptide binding]; other site 529507015564 substrate binding site [chemical binding]; other site 529507015565 active site 529507015566 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 1.1e-12 529507015567 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 529507015568 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 529507015569 substrate-cofactor binding pocket; other site 529507015570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507015571 catalytic residue [active] 529507015572 HMMPfam hit to PF00155, Aminotransferase class I and II, score 3.2e-69 529507015573 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 529507015574 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 529507015575 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 529507015576 NAD(P) binding site [chemical binding]; other site 529507015577 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 8.3e-111 529507015578 PS00059 Zinc-containing alcohol dehydrogenases signature. 529507015579 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 529507015580 NodB motif; other site 529507015581 putative active site [active] 529507015582 putative catalytic site [active] 529507015583 Zn binding site [ion binding]; other site 529507015584 HMMPfam hit to PF04748, Divergent polysaccharide deacetylase, score 1.5e-104 529507015585 Signal peptide predicted for PMI3179 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 30 and 31 529507015586 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 529507015587 Peptidase family M23; Region: Peptidase_M23; pfam01551 529507015588 HMMPfam hit to PF01551, Peptidase family M23, score 1.5e-41 529507015589 Signal peptide predicted for PMI3180 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 39 and 40 529507015590 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 529507015591 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 529507015592 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 529507015593 FeS/SAM binding site; other site 529507015594 HMMPfam hit to PF01938, TRAM domain, score 0.022 529507015595 HMMPfam hit to PF04055, Radical SAM superfamily, score 2.5e-31 529507015596 PS01278 Uncharacterized protein family UPF0004 signature. 529507015597 HMMPfam hit to PF00919, Uncharacterized protein family UPF0004, score 4.7e-42 529507015598 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 529507015599 active site residue [active] 529507015600 1 probable transmembrane helix predicted for PMI3182 by TMHMM2.0 at aa 13-35 529507015601 HMMPfam hit to PF00581, Rhodanese-like domain, score 2.4e-12 529507015602 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 529507015603 SecA binding site; other site 529507015604 Preprotein binding site; other site 529507015605 HMMPfam hit to PF02556, Preprotein translocase subunit SecB, score 4.7e-92 529507015606 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 529507015607 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 529507015608 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 529507015609 Signal peptide predicted for PMI3184 by SignalP 2.0 HMM (Signal peptide probability 0.661) with cleavage site probability 0.575 between residues 18 and 19 529507015610 HMMPfam hit to PF01210, NAD-dependent glycerol-3-phosphate deh, score 3.5e-73 529507015611 HMMPfam hit to PF07479, NAD-dependent glycerol-3-phosphate deh, score 5.5e-80 529507015612 PS00957 NAD-dependent glycerol-3-phosphate dehydrogenase signature. 529507015613 serine acetyltransferase; Provisional; Region: cysE; PRK11132 529507015614 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 529507015615 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 529507015616 trimer interface [polypeptide binding]; other site 529507015617 active site 529507015618 substrate binding site [chemical binding]; other site 529507015619 CoA binding site [chemical binding]; other site 529507015620 HMMPfam hit to PF06426, Serine acetyltransferase, N-terminal, score 3.4e-60 529507015621 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1e+02 529507015622 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 5.5 529507015623 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 16 529507015624 PS00101 Hexapeptide-repeat containing-transferases signature. 529507015625 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.16 529507015626 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 529507015627 putative trimer interface [polypeptide binding]; other site 529507015628 putative CoA binding site [chemical binding]; other site 529507015629 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.32 529507015630 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 5.9 529507015631 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 18 529507015632 O antigen biosynthesis locus 529507015633 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 529507015634 HMMPfam hit to PF00588, SpoU rRNA Methylase family, score 1.2e-48 529507015635 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 529507015636 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 529507015637 putative NAD(P) binding site [chemical binding]; other site 529507015638 active site 529507015639 putative substrate binding site [chemical binding]; other site 529507015640 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 1.2e-118 529507015641 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 529507015642 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 529507015643 LDH/MDH dimer interface [polypeptide binding]; other site 529507015644 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 529507015645 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 529507015646 HMMPfam hit to PF03720, UDP-glucose/GDP-mannose dehydrogenase, score 5.5e-07 529507015647 HMMPfam hit to PF00984, UDP-glucose/GDP-mannose dehydrogenase, score 2.4e-33 529507015648 HMMPfam hit to PF03721, UDP-glucose/GDP-mannose dehydrogenase, score 3.7e-49 529507015649 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 529507015650 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 529507015651 putative ADP-binding pocket [chemical binding]; other site 529507015652 HMMPfam hit to PF00534, Glycosyl transferases group, score 2.7e-31 529507015653 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 529507015654 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 529507015655 HMMPfam hit to PF00534, Glycosyl transferases group, score 1.9e-06 529507015656 9 probable transmembrane helices predicted for PMI3192 by TMHMM2.0 at aa 24-46, 61-83, 96-115, 125-147, 164-186, 201-223, 230-252, 310-332 and 358-380 529507015657 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 529507015658 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 529507015659 Signal peptide predicted for PMI3193 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.932 between residues 43 and 44 529507015660 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 529507015661 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 529507015662 11 probable transmembrane helices predicted for PMI3194 by TMHMM2.0 at aa 42-64, 77-99, 104-126, 139-156, 160-182, 203-225, 240-262, 274-296, 311-330, 337-359 and 364-386 529507015663 HMMPfam hit to PF01943, Polysaccharide biosynthesis protein, score 5e-11 529507015664 putative glycosyl transferase; Provisional; Region: PRK10073 529507015665 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 529507015666 active site 529507015667 HMMPfam hit to PF00535, Glycosyl transferase, score 1.6e-41 529507015668 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 529507015669 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 529507015670 active site 529507015671 HMMPfam hit to PF00535, Glycosyl transferase, score 7.1e-43 529507015672 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 529507015673 two-component sensor protein; Provisional; Region: cpxA; PRK09470 529507015674 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 529507015675 dimerization interface [polypeptide binding]; other site 529507015676 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 529507015677 dimer interface [polypeptide binding]; other site 529507015678 phosphorylation site [posttranslational modification] 529507015679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 529507015680 ATP binding site [chemical binding]; other site 529507015681 Mg2+ binding site [ion binding]; other site 529507015682 G-X-G motif; other site 529507015683 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 5.2e-36 529507015684 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 8.3e-18 529507015685 HMMPfam hit to PF00672, HAMP domain, score 3.2e-12 529507015686 2 probable transmembrane helices predicted for PMI3198 by TMHMM2.0 at aa 5-27 and 165-187 529507015687 Signal peptide predicted for PMI3198 by SignalP 2.0 HMM (Signal peptide probability 0.848) with cleavage site probability 0.423 between residues 26 and 27 529507015688 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 529507015689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507015690 active site 529507015691 phosphorylation site [posttranslational modification] 529507015692 intermolecular recognition site; other site 529507015693 dimerization interface [polypeptide binding]; other site 529507015694 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 529507015695 DNA binding site [nucleotide binding] 529507015696 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 1.5e-21 529507015697 HMMPfam hit to PF00072, Response regulator receiver domain, score 8.9e-43 529507015698 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 529507015699 dimer interface [polypeptide binding]; other site 529507015700 Signal peptide predicted for PMI3200 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.961 between residues 22 and 23 529507015701 HMMPfam hit to PF07813, LTXXQ motif, score 0.0032 529507015702 HMMPfam hit to PF07813, LTXXQ motif, score 0.00015 529507015703 Predicted transcriptional regulator [Transcription]; Region: COG2944 529507015704 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507015705 non-specific DNA binding site [nucleotide binding]; other site 529507015706 salt bridge; other site 529507015707 sequence-specific DNA binding site [nucleotide binding]; other site 529507015708 HMMPfam hit to PF01381, Helix-turn-helix, score 9.7e-05 529507015709 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 529507015710 classical (c) SDRs; Region: SDR_c; cd05233 529507015711 NAD(P) binding site [chemical binding]; other site 529507015712 active site 529507015713 HMMPfam hit to PF00106, short chain dehydrogenase, score 1.9e-68 529507015714 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 529507015715 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 529507015716 active site 529507015717 ADP/pyrophosphate binding site [chemical binding]; other site 529507015718 dimerization interface [polypeptide binding]; other site 529507015719 allosteric effector site; other site 529507015720 fructose-1,6-bisphosphate binding site; other site 529507015721 HMMPfam hit to PF00365, Phosphofructokinase, score 1.7e-180 529507015722 PS00433 Phosphofructokinase signature. 529507015723 sulfate transporter subunit; Provisional; Region: PRK10752 529507015724 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 529507015725 Signal peptide predicted for PMI3204 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 23 and 24 529507015726 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 4.8e-08 529507015727 PS00757 Prokaryotic sulfate-binding proteins signature 2. 529507015728 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 529507015729 triosephosphate isomerase; Provisional; Region: PRK14567 529507015730 substrate binding site [chemical binding]; other site 529507015731 dimer interface [polypeptide binding]; other site 529507015732 catalytic triad [active] 529507015733 HMMPfam hit to PF00121, Triosephosphate isomerase, score 3.3e-146 529507015734 PS00171 Triosephosphate isomerase active site. 529507015735 PS00017 ATP/GTP-binding site motif A (P-loop). 529507015736 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 529507015737 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 529507015738 HMMPfam hit to PF07305, Protein of unknown function (DUF1454), score 9.3e-22 529507015739 Signal peptide predicted for PMI3206 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.908 between residues 27 and 28 529507015740 Predicted membrane protein [Function unknown]; Region: COG3152 529507015741 HMMPfam hit to PF05656, Protein of unknown function (DUF805), score 4.6e-29 529507015742 4 probable transmembrane helices predicted for PMI3207 by TMHMM2.0 at aa 19-36, 40-62, 74-91 and 101-123 529507015743 ferredoxin-NADP reductase; Provisional; Region: PRK10926 529507015744 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 529507015745 FAD binding pocket [chemical binding]; other site 529507015746 FAD binding motif [chemical binding]; other site 529507015747 phosphate binding motif [ion binding]; other site 529507015748 beta-alpha-beta structure motif; other site 529507015749 NAD binding pocket [chemical binding]; other site 529507015750 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 3.2e-20 529507015751 HMMPfam hit to PF00970, Oxidoreductase FAD-binding domain, score 5.8e-06 529507015752 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 529507015753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507015754 putative substrate translocation pore; other site 529507015755 Signal peptide predicted for PMI3209 by SignalP 2.0 HMM (Signal peptide probability 0.957) with cleavage site probability 0.446 between residues 20 and 21 529507015756 12 probable transmembrane helices predicted for PMI3209 by TMHMM2.0 at aa 7-29, 44-66, 75-92, 96-115, 136-158, 163-182, 203-225, 240-262, 275-297, 301-323, 330-352 and 362-384 529507015757 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.3e-38 529507015758 glycerol kinase; Provisional; Region: glpK; PRK00047 529507015759 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 529507015760 N- and C-terminal domain interface [polypeptide binding]; other site 529507015761 active site 529507015762 MgATP binding site [chemical binding]; other site 529507015763 catalytic site [active] 529507015764 metal binding site [ion binding]; metal-binding site 529507015765 glycerol binding site [chemical binding]; other site 529507015766 homotetramer interface [polypeptide binding]; other site 529507015767 homodimer interface [polypeptide binding]; other site 529507015768 FBP binding site [chemical binding]; other site 529507015769 protein IIAGlc interface [polypeptide binding]; other site 529507015770 HMMPfam hit to PF02782, FGGY family of carbohydrate kinases, C-termi, score 7.3e-103 529507015771 PS00445 FGGY family of carbohydrate kinases signature 2. 529507015772 HMMPfam hit to PF00370, FGGY family of carbohydrate kinases, N-termi, score 5.1e-127 529507015773 PS00933 FGGY family of carbohydrate kinases signature 1. 529507015774 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 529507015775 amphipathic channel; other site 529507015776 Asn-Pro-Ala signature motifs; other site 529507015777 6 probable transmembrane helices predicted for PMI3211 by TMHMM2.0 at aa 13-35, 45-67, 88-110, 144-166, 179-201 and 231-253 529507015778 HMMPfam hit to PF00230, Major intrinsic protein, score 5.1e-110 529507015779 PS00221 MIP family signature. 529507015780 Signal peptide predicted for PMI3211 by SignalP 2.0 HMM (Signal peptide probability 0.817) with cleavage site probability 0.420 between residues 38 and 39 529507015781 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507015782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 529507015783 HMMPfam hit to PF06005, Protein of unknown function (DUF904), score 2e-42 529507015784 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 529507015785 HMMPfam hit to PF03737, Demethylmenaquinone methyltransferase, score 3e-74 529507015786 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 529507015787 UbiA prenyltransferase family; Region: UbiA; pfam01040 529507015788 9 probable transmembrane helices predicted for PMI3214 by TMHMM2.0 at aa 20-42, 46-68, 103-122, 132-149, 156-178, 182-204, 230-252, 256-273 and 286-308 529507015789 HMMPfam hit to PF01040, UbiA prenyltransferase family, score 2.4e-32 529507015790 Signal peptide predicted for PMI3214 by SignalP 2.0 HMM (Signal peptide probability 0.970) with cleavage site probability 0.970 between residues 36 and 37 529507015791 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 529507015792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 529507015793 Walker A motif; other site 529507015794 ATP binding site [chemical binding]; other site 529507015795 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 529507015796 Walker B motif; other site 529507015797 arginine finger; other site 529507015798 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 529507015799 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 1.7e-06 529507015800 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 7.9e-54 529507015801 PS00017 ATP/GTP-binding site motif A (P-loop). 529507015802 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 529507015803 active site 529507015804 HslU subunit interaction site [polypeptide binding]; other site 529507015805 HMMPfam hit to PF00227, Proteasome A-type and B-type, score 4.3e-47 529507015806 Sporulation related domain; Region: SPOR; cl10051 529507015807 cell division protein FtsN; Provisional; Region: PRK12757 529507015808 Sporulation related domain; Region: SPOR; cl10051 529507015809 HMMPfam hit to PF05036, Sporulation related repeat, score 0.019 529507015810 HMMPfam hit to PF05036, Sporulation related repeat, score 6.3e-07 529507015811 1 probable transmembrane helix predicted for PMI3217 by TMHMM2.0 at aa 21-43 529507015812 Signal peptide predicted for PMI3217 by SignalP 2.0 HMM (Signal peptide probability 0.971) with cleavage site probability 0.534 between residues 43 and 44 529507015813 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 529507015814 DNA binding site [nucleotide binding] 529507015815 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 529507015816 domain linker motif; other site 529507015817 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 529507015818 dimerization interface [polypeptide binding]; other site 529507015819 ligand binding site [chemical binding]; other site 529507015820 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 1.4e-28 529507015821 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 6.8e-11 529507015822 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 529507015823 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 529507015824 ATP binding site [chemical binding]; other site 529507015825 putative Mg++ binding site [ion binding]; other site 529507015826 helicase superfamily c-terminal domain; Region: HELICc; smart00490 529507015827 ATP-binding site [chemical binding]; other site 529507015828 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.1e-06 529507015829 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 4.5e-20 529507015830 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 1.7e-08 529507015831 PS00017 ATP/GTP-binding site motif A (P-loop). 529507015832 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 529507015833 HMMPfam hit to PF01197, Ribosomal protein L31, score 2e-39 529507015834 PS00190 Cytochrome c family heme-binding site signature. 529507015835 conserved hypothetical protein (fragment) 529507015836 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 529507015837 dimerization interface [polypeptide binding]; other site 529507015838 DNA binding site [nucleotide binding] 529507015839 corepressor binding sites; other site 529507015840 HMMPfam hit to PF01340, Met Apo-repressor, MetJ, score 2.3e-83 529507015841 cystathionine gamma-synthase; Provisional; Region: PRK08045 529507015842 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 529507015843 homodimer interface [polypeptide binding]; other site 529507015844 substrate-cofactor binding pocket; other site 529507015845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507015846 catalytic residue [active] 529507015847 HMMPfam hit to PF01053, Cys/Met metabolism PLP-dependent enzy, score 1.6e-197 529507015848 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 529507015849 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 529507015850 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 529507015851 putative catalytic residues [active] 529507015852 putative nucleotide binding site [chemical binding]; other site 529507015853 putative aspartate binding site [chemical binding]; other site 529507015854 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 529507015855 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 529507015856 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 529507015857 HMMPfam hit to PF00696, Amino acid kinase family, score 5e-41 529507015858 PS00324 Aspartokinase signature. 529507015859 HMMPfam hit to PF03447, homoserine dehydrogenase, NAD binding d, score 7.2e-32 529507015860 HMMPfam hit to PF00742, homoserine dehydrogenase, score 3.7e-96 529507015861 PS01042 homoserine dehydrogenase signature. 529507015862 hypothetical protein; Provisional; Region: PRK05208 529507015863 HMMPfam hit to PF03350, Uncharacterized protein family, UPF0114, score 2.7e-95 529507015864 Signal peptide predicted for PMI3225 by SignalP 2.0 HMM (Signal peptide probability 0.658) with cleavage site probability 0.578 between residues 29 and 30 529507015865 4 probable transmembrane helices predicted for PMI3225 by TMHMM2.0 at aa 13-35, 55-77, 109-126 and 136-155 529507015866 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 529507015867 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 529507015868 HMMPfam hit to PF00311, Phosphoenolpyruvate carboxylase, score 7.6e-227 529507015869 PS00781 Phosphoenolpyruvate carboxylase active site 1. 529507015870 PS00393 Phosphoenolpyruvate carboxylase active site 2. 529507015871 putative glycosyl transferase; Provisional; Region: PRK10073 529507015872 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 529507015873 active site 529507015874 HMMPfam hit to PF00535, Glycosyl transferase, score 3.7e-37 529507015875 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 529507015876 DNA photolyase; Region: DNA_photolyase; pfam00875 529507015877 HMMPfam hit to PF03441, FAD binding domain of DNA photolyase, score 5.7e-136 529507015878 PS00691 DNA photolyases class 1 signature 2. 529507015879 PS00394 DNA photolyases class 1 signature 1. 529507015880 HMMPfam hit to PF00875, DNA photolyase, score 1.3e-43 529507015881 proline/glycine betaine transporter; Provisional; Region: PRK10642 529507015882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507015883 putative substrate translocation pore; other site 529507015884 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 529507015885 HMMPfam hit to PF00083, Sugar (and other) transporter, score 6.2e-89 529507015886 12 probable transmembrane helices predicted for PMI3230 by TMHMM2.0 at aa 42-64, 69-91, 98-120, 125-147, 168-190, 200-222, 261-283, 298-320, 327-345, 355-377, 390-412 and 422-440 529507015887 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.2e-24 529507015888 PS00216 Sugar transport proteins signature 1. 529507015889 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 529507015890 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507015891 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 529507015892 substrate binding site [chemical binding]; other site 529507015893 dimerization interface [polypeptide binding]; other site 529507015894 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.9e-15 529507015895 PS00044 Bacterial regulatory proteins, lysR family signature. 529507015896 HMMPfam hit to PF03466, LysR substrate binding domain, score 6.3e-28 529507015897 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 529507015898 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 529507015899 metal binding site [ion binding]; metal-binding site 529507015900 dimer interface [polypeptide binding]; other site 529507015901 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 7.1e-35 529507015902 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 2.2e-08 529507015903 4 probable transmembrane helices predicted for PMI3233 by TMHMM2.0 at aa 21-43, 53-75, 82-104 and 114-136 529507015904 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 529507015905 7 probable transmembrane helices predicted for PMI3234 by TMHMM2.0 at aa 7-29, 39-61, 78-100, 110-132, 167-189, 199-221 and 233-255 529507015906 Signal peptide predicted for PMI3234 by SignalP 2.0 HMM (Signal peptide probability 0.952) with cleavage site probability 0.940 between residues 30 and 31 529507015907 pyruvate dehydrogenase; Provisional; Region: PRK09124 529507015908 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 529507015909 PYR/PP interface [polypeptide binding]; other site 529507015910 dimer interface [polypeptide binding]; other site 529507015911 tetramer interface [polypeptide binding]; other site 529507015912 TPP binding site [chemical binding]; other site 529507015913 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 529507015914 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 529507015915 TPP-binding site [chemical binding]; other site 529507015916 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 3.1e-72 529507015917 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 5.2e-38 529507015918 acetylornithine deacetylase; Provisional; Region: PRK05111 529507015919 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 529507015920 metal binding site [ion binding]; metal-binding site 529507015921 putative dimer interface [polypeptide binding]; other site 529507015922 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 1.1e-35 529507015923 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 2.5e-30 529507015924 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 529507015925 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 529507015926 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 529507015927 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 529507015928 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD bindi, score 3.3e-42 529507015929 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 529507015930 HMMPfam hit to PF02774, Semialdehyde dehydrogenase, dimerisat, score 3.2e-36 529507015931 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 529507015932 nucleotide binding site [chemical binding]; other site 529507015933 N-acetyl-L-glutamate binding site [chemical binding]; other site 529507015934 HMMPfam hit to PF00696, Amino acid kinase family, score 4.7e-40 529507015935 argininosuccinate synthase; Provisional; Region: PRK13820 529507015936 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 529507015937 ANP binding site [chemical binding]; other site 529507015938 Substrate Binding Site II [chemical binding]; other site 529507015939 Substrate Binding Site I [chemical binding]; other site 529507015940 HMMPfam hit to PF00764, Arginosuccinate synthase, score 1.4e-177 529507015941 PS00564 Argininosuccinate synthase signature 1. 529507015942 PS00565 Argininosuccinate synthase signature 2. 529507015943 argininosuccinate lyase; Provisional; Region: PRK04833 529507015944 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 529507015945 active sites [active] 529507015946 tetramer interface [polypeptide binding]; other site 529507015947 HMMPfam hit to PF00206, Lyase, score 8.8e-130 529507015948 PS00163 Fumarate lyases signature. 529507015949 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 529507015950 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507015951 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 529507015952 dimerization interface [polypeptide binding]; other site 529507015953 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.5e-20 529507015954 PS00044 Bacterial regulatory proteins, lysR family signature. 529507015955 HMMPfam hit to PF03466, LysR substrate binding domain, score 4.9e-55 529507015956 PS00139 Eukaryotic thiol (cysteine) proteases cysteine active site. 529507015957 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 529507015958 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 529507015959 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 529507015960 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidored, score 2.3e-38 529507015961 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidored, score 1.4e-71 529507015962 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507015963 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 529507015964 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 529507015965 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 1.2e-11 529507015966 hypothetical protein; Provisional; Region: PRK11056 529507015967 HMMPfam hit to PF07226, Protein of unknown function (DUF1422), score 1e-33 529507015968 4 probable transmembrane helices predicted for PMI3244 by TMHMM2.0 at aa 12-30, 34-53, 65-82 and 92-109 529507015969 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 529507015970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507015971 S-adenosylmethionine binding site [chemical binding]; other site 529507015972 HMMPfam hit to PF05958, tRNA (Uracil-5-)-methyltransferase, score 1.9e-271 529507015973 PS01231 RNA methyltransferase trmA family signature 2. 529507015974 PS01230 RNA methyltransferase trmA family signature 1. 529507015975 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 529507015976 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 529507015977 N-terminal plug; other site 529507015978 ligand-binding site [chemical binding]; other site 529507015979 PS00430 TonB-dependent receptor proteins signature 1. 529507015980 Signal peptide predicted for PMI3246 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.516 between residues 27 and 28 529507015981 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 6.7e-25 529507015982 HMMPfam hit to PF00593, TonB dependent receptor, score 2.8e-31 529507015983 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS01156 TonB-dependent receptor proteins signature 2. 529507015984 glutamate racemase; Provisional; Region: PRK00865 529507015985 HMMPfam hit to PF01177, Asp/Glu/Hydantoin racemase, score 8.2e-83 529507015986 PS00923 Aspartate and glutamate racemases signature 1. 529507015987 PS00924 Aspartate and glutamate racemases signature 2. 529507015988 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 529507015989 FAD binding domain; Region: FAD_binding_4; pfam01565 529507015990 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 529507015991 HMMPfam hit to PF01565, FAD binding domain, score 6.4e-06 529507015992 HMMPfam hit to PF02873, UDP-N-acetylenolpyruvoylglucosamine red, score 3.3e-52 529507015993 Biotin operon repressor [Transcription]; Region: BirA; COG1654 529507015994 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 529507015995 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 529507015996 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 529507015997 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase famil, score 5.7e-37 529507015998 HMMPfam hit to PF02237, Biotin protein ligase C terminal domain, score 8.6e-11 529507015999 pantothenate kinase; Provisional; Region: PRK05439 529507016000 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 529507016001 ATP-binding site [chemical binding]; other site 529507016002 CoA-binding site [chemical binding]; other site 529507016003 Mg2+-binding site [ion binding]; other site 529507016004 HMMPfam hit to PF00485, Phosphoribulokinase / Uridine kinase family, score 4.9e-07 529507016005 PS00017 ATP/GTP-binding site motif A (P-loop). 529507016006 elongation factor Tu; Reviewed; Region: PRK00049 529507016007 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 529507016008 G1 box; other site 529507016009 GEF interaction site [polypeptide binding]; other site 529507016010 GTP/Mg2+ binding site [chemical binding]; other site 529507016011 Switch I region; other site 529507016012 G2 box; other site 529507016013 G3 box; other site 529507016014 Switch II region; other site 529507016015 G4 box; other site 529507016016 G5 box; other site 529507016017 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 529507016018 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 529507016019 Antibiotic Binding Site [chemical binding]; other site 529507016020 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 7e-98 529507016021 PS00017 ATP/GTP-binding site motif A (P-loop). 529507016022 PS00301 GTP-binding elongation factors signature. 529507016023 HMMPfam hit to PF03144, Elongation factor Tu domain, score 8e-26 529507016024 HMMPfam hit to PF03143, Elongation factor Tu C-terminal domain, score 9.6e-62 529507016025 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 529507016026 HMMPfam hit to PF04324, BFD-like [2Fe-2S] binding domain, score 6.3e-16 529507016027 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 529507016028 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 529507016029 heme binding site [chemical binding]; other site 529507016030 ferroxidase pore; other site 529507016031 ferroxidase diiron center [ion binding]; other site 529507016032 HMMPfam hit to PF00210, Ferritin-like domain, score 1.3e-50 529507016033 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 529507016034 HMMPfam hit to PF00338, Ribosomal protein S10p/S20e, score 7.9e-61 529507016035 PS00361 Ribosomal protein S10 signature. 529507016036 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 529507016037 HMMPfam hit to PF00297, Ribosomal protein L3, score 1.4e-103 529507016038 PS00474 Ribosomal protein L3 signature. 529507016039 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 529507016040 HMMPfam hit to PF00573, Ribosomal protein L4/L1 family, score 3.4e-57 529507016041 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 529507016042 HMMPfam hit to PF00276, Ribosomal protein L23, score 1.9e-43 529507016043 PS00050 Ribosomal protein L23 signature. 529507016044 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 529507016045 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 529507016046 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 529507016047 HMMPfam hit to PF00181, Ribosomal Proteins L2, RNA binding dom, score 4.1e-46 529507016048 HMMPfam hit to PF03947, Ribosomal Proteins L2, C-terminal doma, score 2.5e-85 529507016049 PS00467 Ribosomal protein L2 signature. 529507016050 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 529507016051 HMMPfam hit to PF00203, Ribosomal protein S19, score 8.3e-55 529507016052 PS00323 Ribosomal protein S19 signature. 529507016053 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 529507016054 protein-rRNA interface [nucleotide binding]; other site 529507016055 putative translocon binding site; other site 529507016056 HMMPfam hit to PF00237, Ribosomal protein L22p/L17e, score 6.7e-58 529507016057 PS00464 Ribosomal protein L22 signature. 529507016058 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 529507016059 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 529507016060 G-X-X-G motif; other site 529507016061 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 529507016062 HMMPfam hit to PF00417, Ribosomal protein S3, N-terminal domai, score 4.3e-28 529507016063 HMMPfam hit to PF07650, KH domain, score 3.9e-20 529507016064 HMMPfam hit to PF00189, Ribosomal protein S3, C-terminal domai, score 1.2e-54 529507016065 PS00548 Ribosomal protein S3 signature. 529507016066 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 529507016067 23S rRNA interface [nucleotide binding]; other site 529507016068 5S rRNA interface [nucleotide binding]; other site 529507016069 putative antibiotic binding site [chemical binding]; other site 529507016070 L25 interface [polypeptide binding]; other site 529507016071 L27 interface [polypeptide binding]; other site 529507016072 HMMPfam hit to PF00252, Ribosomal protein L16, score 1.2e-92 529507016073 PS00586 Ribosomal protein L16 signature 1. 529507016074 PS00701 Ribosomal protein L16 signature 2. 529507016075 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 529507016076 23S rRNA interface [nucleotide binding]; other site 529507016077 putative translocon interaction site; other site 529507016078 signal recognition particle (SRP54) interaction site; other site 529507016079 L23 interface [polypeptide binding]; other site 529507016080 trigger factor interaction site; other site 529507016081 HMMPfam hit to PF00831, Ribosomal L29 protein, score 9.1e-29 529507016082 PS00579 Ribosomal protein L29 signature. 529507016083 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 529507016084 HMMPfam hit to PF00366, Ribosomal protein S17, score 1e-40 529507016085 PS00056 Ribosomal protein S17 signature. 529507016086 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 529507016087 HMMPfam hit to PF00238, Ribosomal protein L14p/L23e, score 4.3e-78 529507016088 PS00049 Ribosomal protein L14 signature. 529507016089 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 529507016090 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 529507016091 RNA binding site [nucleotide binding]; other site 529507016092 HMMPfam hit to PF00467, KOW motif, score 4.7e-06 529507016093 PS01108 Ribosomal protein L24 signature. 529507016094 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 529507016095 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 529507016096 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 529507016097 HMMPfam hit to PF00281, Ribosomal protein L5, score 1.4e-33 529507016098 PS00358 Ribosomal protein L5 signature. 529507016099 HMMPfam hit to PF00673, ribosomal L5P family C-terminus, score 4.3e-59 529507016100 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 529507016101 HMMPfam hit to PF00253, Ribosomal protein S14p/S29e, score 1.1e-24 529507016102 PS00527 Ribosomal protein S14 signature. 529507016103 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 529507016104 HMMPfam hit to PF00410, Ribosomal protein S8, score 8.3e-72 529507016105 PS00053 Ribosomal protein S8 signature. 529507016106 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 529507016107 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 529507016108 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 529507016109 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 529507016110 HMMPfam hit to PF00347, Ribosomal protein L6, score 1e-22 529507016111 HMMPfam hit to PF00347, Ribosomal protein L6, score 8.2e-30 529507016112 PS00525 Ribosomal protein L6 signature 1. 529507016113 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 529507016114 5S rRNA interface [nucleotide binding]; other site 529507016115 23S rRNA interface [nucleotide binding]; other site 529507016116 L5 interface [polypeptide binding]; other site 529507016117 HMMPfam hit to PF00861, Ribosomal L18p/L5e family, score 5.3e-53 529507016118 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 529507016119 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 529507016120 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 529507016121 HMMPfam hit to PF00333, Ribosomal protein S5, N-terminal domai, score 6.7e-40 529507016122 PS00585 Ribosomal protein S5 signature. 529507016123 HMMPfam hit to PF03719, Ribosomal protein S5, C-terminal domai, score 5.4e-40 529507016124 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 529507016125 23S rRNA binding site [nucleotide binding]; other site 529507016126 HMMPfam hit to PF00327, Ribosomal protein L30p/L7e, score 6.2e-25 529507016127 PS00634 Ribosomal protein L30 signature. 529507016128 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 529507016129 HMMPfam hit to PF01305, Ribosomal protein L15 amino terminal re, score 4.6e-57 529507016130 HMMPfam hit to PF00256, Ribosomal protein L15, score 1.6e-08 529507016131 PS00475 Ribosomal protein L15 signature. 529507016132 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 529507016133 SecY translocase; Region: SecY; pfam00344 529507016134 10 probable transmembrane helices predicted for PMI3275 by TMHMM2.0 at aa 22-44, 76-98, 119-138, 153-175, 182-204, 215-237, 273-295, 315-337, 369-391 and 401-423 529507016135 HMMPfam hit to PF00344, eubacterial secY protein, score 3.1e-197 529507016136 PS00755 Protein secY signature 1. 529507016137 PS00756 Protein secY signature 2. 529507016138 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 529507016139 PS00027 'Homeobox' domain signature. 529507016140 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 529507016141 HMMPfam hit to PF00444, Ribosomal protein L36, score 9.6e-16 529507016142 PS00828 Ribosomal protein L36 signature. 529507016143 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 529507016144 30S ribosomal protein S13; Region: bact_S13; TIGR03631 529507016145 HMMPfam hit to PF00416, Ribosomal protein S13/S18, score 2.9e-59 529507016146 PS00061 Short-chain dehydrogenases/reductases family signature. 529507016147 PS00646 Ribosomal protein S13 signature. 529507016148 30S ribosomal protein S11; Validated; Region: PRK05309 529507016149 HMMPfam hit to PF00411, Ribosomal protein S11, score 2.9e-76 529507016150 PS00054 Ribosomal protein S11 signature. 529507016151 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 529507016152 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 529507016153 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 529507016154 RNA binding surface [nucleotide binding]; other site 529507016155 HMMPfam hit to PF00163, Ribosomal protein S4/S9 N-terminal domai, score 1e-35 529507016156 PS00632 Ribosomal protein S4 signature. 529507016157 HMMPfam hit to PF01479, S4 domain, score 5e-21 529507016158 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 529507016159 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 529507016160 alphaNTD homodimer interface [polypeptide binding]; other site 529507016161 alphaNTD - beta interaction site [polypeptide binding]; other site 529507016162 alphaNTD - beta' interaction site [polypeptide binding]; other site 529507016163 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 529507016164 HMMPfam hit to PF01193, RNA polymerase Rpb3/Rpb11 dimerisation, score 1.1e-20 529507016165 HMMPfam hit to PF01000, RNA polymerase Rpb3/RpoA insert domain, score 3.6e-56 529507016166 HMMPfam hit to PF03118, Bacterial RNA polymerase, alpha chain C, score 1.8e-35 529507016167 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 529507016168 HMMPfam hit to PF01196, Ribosomal protein L17, score 2.6e-66 529507016169 PS01167 Ribosomal protein L17 signature. 529507016170 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 529507016171 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 529507016172 DNA binding residues [nucleotide binding] 529507016173 dimer interface [polypeptide binding]; other site 529507016174 metal binding site [ion binding]; metal-binding site 529507016175 HMMPfam hit to PF00376, MerR family regulatory protein, score 1.4e-12 529507016176 PS00552 Bacterial regulatory proteins, merR family signature. 529507016177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 529507016178 HMMPfam hit to PF03889, Domain of unknown function, score 8.1e-31 529507016179 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 529507016180 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 529507016181 HMMPfam hit to PF01741, Large-conductance mechanosensitive channel,, score 3.9e-83 529507016182 2 probable transmembrane helices predicted for PMI3284 by TMHMM2.0 at aa 20-42 and 77-99 529507016183 PS01327 Large-conductance mechanosensitive channels mscL family signature. 529507016184 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 529507016185 TrkA-N domain; Region: TrkA_N; pfam02254 529507016186 TrkA-C domain; Region: TrkA_C; pfam02080 529507016187 TrkA-N domain; Region: TrkA_N; pfam02254 529507016188 TrkA-C domain; Region: TrkA_C; pfam02080 529507016189 HMMPfam hit to PF02080, TrkA-C domain, score 2.7e-13 529507016190 HMMPfam hit to PF02254, TrkA-N domain, score 2.4e-11 529507016191 HMMPfam hit to PF02080, TrkA-C domain, score 9.7e-12 529507016192 HMMPfam hit to PF02254, TrkA-N domain, score 4.5e-21 529507016193 16S rRNA methyltransferase B; Provisional; Region: PRK10901 529507016194 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 529507016195 putative RNA binding site [nucleotide binding]; other site 529507016196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507016197 S-adenosylmethionine binding site [chemical binding]; other site 529507016198 HMMPfam hit to PF01189, NOL1/NOP2/sun family, score 3.9e-112 529507016199 PS01153 NOL1/NOP2/sun family signature. 529507016200 HMMPfam hit to PF01029, NusB family, score 5.1e-45 529507016201 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 529507016202 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 529507016203 putative active site [active] 529507016204 substrate binding site [chemical binding]; other site 529507016205 putative cosubstrate binding site; other site 529507016206 catalytic site [active] 529507016207 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 529507016208 substrate binding site [chemical binding]; other site 529507016209 HMMPfam hit to PF02911, Formyl transferase, C-terminal domain, score 1.1e-40 529507016210 HMMPfam hit to PF00551, Formyl transferase, score 1.8e-71 529507016211 PS00373 Phosphoribosylglycinamide formyltransferase active site. 529507016212 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 529507016213 active site 529507016214 catalytic residues [active] 529507016215 metal binding site [ion binding]; metal-binding site 529507016216 HMMPfam hit to PF01327, Polypeptide deformylase, score 9.3e-83 529507016217 hypothetical protein; Provisional; Region: PRK10736 529507016218 DNA protecting protein DprA; Region: dprA; TIGR00732 529507016219 HMMPfam hit to PF02481, SMF family, score 7.8e-97 529507016220 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 529507016221 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 529507016222 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 529507016223 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 529507016224 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 7.2e-17 529507016225 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 2.8e-17 529507016226 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 1.8e-14 529507016227 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 529507016228 HMMPfam hit to PF01300, yrdC domain, score 2.7e-67 529507016229 PS01147 SUA5/yciO/yrdC family signature. 529507016230 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 529507016231 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 529507016232 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 529507016233 NAD(P) binding site [chemical binding]; other site 529507016234 shikimate binding site; other site 529507016235 HMMPfam hit to PF01488, Shikimate / quinate 5-dehydrogenase, score 4.6e-86 529507016236 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 529507016237 HMMPfam hit to PF07369, Protein of unknown function (DUF1488), score 4.4e-15 529507016238 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 529507016239 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 529507016240 trimer interface [polypeptide binding]; other site 529507016241 putative metal binding site [ion binding]; other site 529507016242 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 2 529507016243 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1.2 529507016244 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 30 529507016245 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 7.7 529507016246 transcriptional regulator HdfR; Provisional; Region: PRK03601 529507016247 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507016248 LysR substrate binding domain; Region: LysR_substrate; pfam03466 529507016249 dimerization interface [polypeptide binding]; other site 529507016250 HMMPfam hit to PF03466, LysR substrate binding domain, score 4.1e-05 529507016251 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.4e-17 529507016252 PS00044 Bacterial regulatory proteins, lysR family signature. 529507016253 hypothetical protein; Provisional; Region: PRK11027 529507016254 HMMPfam hit to PF04219, Protein of unknown function, DUF, score 4.2e-50 529507016255 putative ATP-dependent protease; Provisional; Region: PRK09862 529507016256 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 529507016257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 529507016258 Walker A motif; other site 529507016259 ATP binding site [chemical binding]; other site 529507016260 Walker B motif; other site 529507016261 arginine finger; other site 529507016262 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 529507016263 HMMPfam hit to PF01078, Magnesium chelatase, subunit ChlI, score 4.7e-67 529507016264 PS00017 ATP/GTP-binding site motif A (P-loop). 529507016265 1 probable transmembrane helix predicted for PMI3298 by TMHMM2.0 at aa 26-48 529507016266 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 529507016267 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 529507016268 PYR/PP interface [polypeptide binding]; other site 529507016269 dimer interface [polypeptide binding]; other site 529507016270 TPP binding site [chemical binding]; other site 529507016271 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 529507016272 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 529507016273 TPP-binding site [chemical binding]; other site 529507016274 dimer interface [polypeptide binding]; other site 529507016275 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 1.9e-94 529507016276 PS00044 Bacterial regulatory proteins, lysR family signature. 529507016277 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 1.1e-63 529507016278 PS00187 Thiamine pyrophosphate enzymes signature. 529507016279 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 529507016280 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 529507016281 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 529507016282 homodimer interface [polypeptide binding]; other site 529507016283 substrate-cofactor binding pocket; other site 529507016284 catalytic residue [active] 529507016285 HMMPfam hit to PF01063, Aminotransferase class IV, score 1.6e-137 529507016286 PS00770 Aminotransferases class-IV signature. 529507016287 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 529507016288 HMMPfam hit to PF00920, Dehydratase family, score 0 529507016289 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 529507016290 PS00017 ATP/GTP-binding site motif A (P-loop). 529507016291 PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 529507016292 threonine dehydratase; Reviewed; Region: PRK09224 529507016293 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 529507016294 tetramer interface [polypeptide binding]; other site 529507016295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507016296 catalytic residue [active] 529507016297 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 529507016298 putative Ile/Val binding site [chemical binding]; other site 529507016299 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 529507016300 putative Ile/Val binding site [chemical binding]; other site 529507016301 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 2.1e-96 529507016302 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 529507016303 HMMPfam hit to PF00585, C-terminal regulatory domain of Threon, score 7.3e-40 529507016304 HMMPfam hit to PF00585, C-terminal regulatory domain of Threon, score 1.7e-39 529507016305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507016306 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 529507016307 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 529507016308 putative dimerization interface [polypeptide binding]; other site 529507016309 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.5e-30 529507016310 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 3e-23 529507016311 PS00044 Bacterial regulatory proteins, lysR family signature. 529507016312 ketol-acid reductoisomerase; Validated; Region: PRK05225 529507016313 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 529507016314 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 529507016315 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 529507016316 HMMPfam hit to PF01450, Acetohydroxy acid isomeroreductase, catalyti, score 4e-133 529507016317 Transposase IS200 like; Region: Y1_Tnp; pfam01797 529507016318 HMMPfam hit to PF01797, Transposase IS200 like, score 2.1e-35 529507016319 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507016320 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 529507016321 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 529507016322 Probable transposase; Region: OrfB_IS605; pfam01385 529507016323 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 529507016324 HMMPfam hit to PF01385, Probable transposase, score 2.3e-130 529507016325 HMMPfam hit to PF07282, transposase DNA-binding domai, score 3.9e-32 529507016326 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507016327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 529507016328 HMMPfam hit to PF05016, Plasmid stabilisation system protein, score 1.4e-08 529507016329 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 529507016330 Part of AAA domain; Region: AAA_19; pfam13245 529507016331 Family description; Region: UvrD_C_2; pfam13538 529507016332 HMMPfam hit to PF00580, UvrD/REP helicase, score 2.3e-213 529507016333 PS00017 ATP/GTP-binding site motif A (P-loop). 529507016334 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 529507016335 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 529507016336 nucleotide binding site [chemical binding]; other site 529507016337 HMMPfam hit to PF02541, Ppx/GppA phosphatase family, score 1.3e-117 529507016338 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 529507016339 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 529507016340 ATP binding site [chemical binding]; other site 529507016341 Mg++ binding site [ion binding]; other site 529507016342 motif III; other site 529507016343 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 529507016344 nucleotide binding region [chemical binding]; other site 529507016345 ATP-binding site [chemical binding]; other site 529507016346 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.2e-34 529507016347 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 1.3e-56 529507016348 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 529507016349 PS00017 ATP/GTP-binding site motif A (P-loop). 529507016350 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 529507016351 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 529507016352 catalytic residues [active] 529507016353 HMMPfam hit to PF00085, Thioredoxin, score 1.8e-47 529507016354 PS00194 Thioredoxin family active site. 529507016355 transcription termination factor Rho; Provisional; Region: rho; PRK09376 529507016356 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 529507016357 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 529507016358 RNA binding site [nucleotide binding]; other site 529507016359 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 529507016360 multimer interface [polypeptide binding]; other site 529507016361 Walker A motif; other site 529507016362 ATP binding site [chemical binding]; other site 529507016363 Walker B motif; other site 529507016364 HMMPfam hit to PF07498, Rho termination factor, N-terminal domai, score 4.1e-20 529507016365 HMMPfam hit to PF07497, Rho termination factor, RNA-binding doma, score 2.1e-58 529507016366 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleoti, score 1e-68 529507016367 PS00017 ATP/GTP-binding site motif A (P-loop). 529507016368 1 probable transmembrane helix predicted for PMI3315 by TMHMM2.0 at aa 2-24 529507016369 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 529507016370 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 529507016371 Mg++ binding site [ion binding]; other site 529507016372 putative catalytic motif [active] 529507016373 substrate binding site [chemical binding]; other site 529507016374 11 probable transmembrane helices predicted for PMI3316 by TMHMM2.0 at aa 10-24, 45-64, 68-87, 99-116, 131-153, 160-179, 184-206, 213-232, 242-261, 294-311 and 321-343 529507016375 HMMPfam hit to PF00953, Glycosyl transferase, score 1.1e-08 529507016376 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 529507016377 Chain length determinant protein; Region: Wzz; cl15801 529507016378 HMMPfam hit to PF02706, Chain length determinant protein, score 1.6e-06 529507016379 2 probable transmembrane helices predicted for PMI3317 by TMHMM2.0 at aa 34-53 and 327-346 529507016380 PS00221 MIP family signature. 529507016381 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 529507016382 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 529507016383 active site 529507016384 homodimer interface [polypeptide binding]; other site 529507016385 HMMPfam hit to PF02350, UDP-N-acetylglucosamine 2-epimerase, score 2.4e-195 529507016386 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 529507016387 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 529507016388 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 529507016389 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 529507016390 Signal peptide predicted for PMI3319 by SignalP 2.0 HMM (Signal peptide probability 0.674) with cleavage site probability 0.574 between residues 23 and 24 529507016391 HMMPfam hit to PF03721, UDP-glucose/GDP-mannose dehydrogenase, score 2e-89 529507016392 HMMPfam hit to PF00984, UDP-glucose/GDP-mannose dehydrogenase, score 5.6e-41 529507016393 PS00678 Trp-Asp (WD) repeats signature. 529507016394 HMMPfam hit to PF03720, UDP-glucose/GDP-mannose dehydrogenase, score 8e-26 529507016395 PS00017 ATP/GTP-binding site motif A (P-loop). 529507016396 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 529507016397 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 529507016398 NAD binding site [chemical binding]; other site 529507016399 substrate binding site [chemical binding]; other site 529507016400 homodimer interface [polypeptide binding]; other site 529507016401 active site 529507016402 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 9.4e-210 529507016403 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 529507016404 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 529507016405 substrate binding site; other site 529507016406 tetramer interface; other site 529507016407 HMMPfam hit to PF00483, Nucleotidyl transferase, score 1.6e-112 529507016408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 529507016409 Coenzyme A binding pocket [chemical binding]; other site 529507016410 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.3e-13 529507016411 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 529507016412 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 529507016413 inhibitor-cofactor binding pocket; inhibition site 529507016414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 529507016415 catalytic residue [active] 529507016416 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 3.9e-88 529507016417 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 529507016418 HMMPfam hit to PF01943, Polysaccharide biosynthesis protein, score 1.6e-05 529507016419 12 probable transmembrane helices predicted for PMI3324 by TMHMM2.0 at aa 13-35, 45-67, 88-110, 120-139, 151-173, 178-197, 218-240, 255-277, 298-320, 335-357, 364-383 and 393-415 529507016420 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929 529507016421 HMMPfam hit to PF07429, 4-alpha-L-fucosyltransferase (Fuc4NAc, score 8.4e-189 529507016422 putative common antigen polymerase; Provisional; Region: PRK02975 529507016423 HMMPfam hit to PF06899, WzyE protein, score 0 529507016424 11 probable transmembrane helices predicted for PMI3326 by TMHMM2.0 at aa 4-25, 38-60, 70-89, 110-132, 152-174, 181-200, 204-223, 225-244, 337-359, 380-397 and 407-429 529507016425 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 529507016426 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507016427 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 529507016428 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 529507016429 HMMPfam hit to PF03808, Glycosyl transferase WecB/TagA/CpsF f, score 4.2e-88 529507016430 3 probable transmembrane helices predicted for PMI3328 by TMHMM2.0 at aa 13-35, 40-59 and 79-101 529507016431 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 529507016432 HemY protein N-terminus; Region: HemY_N; pfam07219 529507016433 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.00014 529507016434 HMMPfam hit to PF07219, HemY protein N-terminus, score 7.9e-55 529507016435 2 probable transmembrane helices predicted for PMI3329 by TMHMM2.0 at aa 7-29 and 39-61 529507016436 Signal peptide predicted for PMI3329 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.977 between residues 22 and 23 529507016437 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 529507016438 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 529507016439 HMMPfam hit to PF04375, HemX, score 4.4e-124 529507016440 1 probable transmembrane helix predicted for PMI3330 by TMHMM2.0 at aa 38-60 529507016441 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 529507016442 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 529507016443 active site 529507016444 HMMPfam hit to PF02602, Uroporphyrinogen-III synthase HemD, score 3.3e-25 529507016445 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 529507016446 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 529507016447 domain interfaces; other site 529507016448 active site 529507016449 HMMPfam hit to PF03900, Porphobilinogen deaminase, C-terminal, score 2.1e-31 529507016450 PS00533 Porphobilinogen deaminase cofactor-binding site. 529507016451 HMMPfam hit to PF01379, Porphobilinogen deaminase, dipyrometh, score 1.1e-137 529507016452 adenylate cyclase; Provisional; Region: cyaA; PRK09450 529507016453 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 529507016454 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 529507016455 HMMPfam hit to PF01295, Adenylate cyclase, class-I, score 0 529507016456 PS01092 Adenylate cyclases class-I signature 1. 529507016457 PS01093 Adenylate cyclases class-I signature 2. 529507016458 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 529507016459 putative iron binding site [ion binding]; other site 529507016460 HMMPfam hit to PF01491, Frataxin-like domain, score 4.9e-57 529507016461 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 529507016462 Signal peptide predicted for PMI3335 by SignalP 2.0 HMM (Signal peptide probability 0.796) with cleavage site probability 0.495 between residues 29 and 30 529507016463 1 probable transmembrane helix predicted for PMI3335 by TMHMM2.0 at aa 13-35 529507016464 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507016465 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 529507016466 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 529507016467 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 529507016468 HMMPfam hit to PF01678, Diaminopimelate epimerase, score 1.1e-47 529507016469 PS01326 Diaminopimelate epimerase signature. 529507016470 HMMPfam hit to PF01678, Diaminopimelate epimerase, score 6.4e-49 529507016471 hypothetical protein; Provisional; Region: PRK10963 529507016472 HMMPfam hit to PF04340, Protein of unknown function, DUF484, score 5e-72 529507016473 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 529507016474 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 529507016475 active site 529507016476 Int/Topo IB signature motif; other site 529507016477 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 4.1e-30 529507016478 HMMPfam hit to PF00589, Phage integrase family, score 1.2e-59 529507016479 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 529507016480 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 529507016481 motif II; other site 529507016482 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 8.1e-20 529507016483 PS00761 Signal peptidases I signature 3. 529507016484 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 529507016485 Part of AAA domain; Region: AAA_19; pfam13245 529507016486 Family description; Region: UvrD_C_2; pfam13538 529507016487 HMMPfam hit to PF00580, UvrD/REP helicase, score 7.5e-215 529507016488 PS00017 ATP/GTP-binding site motif A (P-loop). 529507016489 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 529507016490 EamA-like transporter family; Region: EamA; pfam00892 529507016491 10 probable transmembrane helices predicted for PMI3342 by TMHMM2.0 at aa 33-50, 65-87, 100-122, 126-148, 155-172, 177-194, 207-226, 236-258, 265-287 and 297-316 529507016492 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 3.9e-12 529507016493 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 529507016494 CoenzymeA binding site [chemical binding]; other site 529507016495 subunit interaction site [polypeptide binding]; other site 529507016496 PHB binding site; other site 529507016497 HMMPfam hit to PF03061, Thioesterase superfamily, score 5e-06 529507016498 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 529507016499 dimerization interface [polypeptide binding]; other site 529507016500 substrate binding site [chemical binding]; other site 529507016501 active site 529507016502 calcium binding site [ion binding]; other site 529507016503 Signal peptide predicted for PMI3344 by SignalP 2.0 HMM (Signal peptide probability 0.689) with cleavage site probability 0.442 between residues 21 and 22 529507016504 HMMPfam hit to PF02253, Phospholipase A1, score 1.2e-151 529507016505 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 529507016506 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 529507016507 ATP binding site [chemical binding]; other site 529507016508 putative Mg++ binding site [ion binding]; other site 529507016509 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 529507016510 nucleotide binding region [chemical binding]; other site 529507016511 ATP-binding site [chemical binding]; other site 529507016512 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 529507016513 HRDC domain; Region: HRDC; pfam00570 529507016514 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 1.4e-33 529507016515 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 9.1e-30 529507016516 HMMPfam hit to PF00570, HRDC domain, score 2.5e-24 529507016517 lysophospholipase L2; Provisional; Region: PRK10749 529507016518 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 529507016519 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 9.8e-20 529507016520 putative hydrolase; Provisional; Region: PRK10976 529507016521 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 529507016522 active site 529507016523 motif I; other site 529507016524 motif II; other site 529507016525 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 529507016526 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 8.8e-05 529507016527 PS01228 Hypothetical cof family signature 1. 529507016528 PS01229 Hypothetical cof family signature 2. 529507016529 fimbrial operon 16 529507016530 putative major fimbrial protein SthE; Provisional; Region: PRK15292 529507016531 Fimbrial protein; Region: Fimbrial; cl01416 529507016532 HMMPfam hit to PF00419, Fimbrial protein, score 2.5e-06 529507016533 Signal peptide predicted for PMI3348 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.908 between residues 24 and 25 529507016534 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 529507016535 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 529507016536 PapC N-terminal domain; Region: PapC_N; pfam13954 529507016537 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 529507016538 PapC C-terminal domain; Region: PapC_C; pfam13953 529507016539 HMMPfam hit to PF00577, Fimbrial Usher protein, score 0 529507016540 Signal peptide predicted for PMI3349 by SignalP 2.0 HMM (Signal peptide probability 0.610) with cleavage site probability 0.593 between residues 42 and 43 529507016541 1 probable transmembrane helix predicted for PMI3349 by TMHMM2.0 at aa 20-42 529507016542 fimbrial chaperone protein PefD; Provisional; Region: PRK15211 529507016543 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 529507016544 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 529507016545 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 5.8e-35 529507016546 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507016547 HMMPfam hit to PF00419, Fimbrial protein, score 1.4e-41 529507016548 1 probable transmembrane helix predicted for PMI3352 by TMHMM2.0 at aa 7-29 529507016549 Signal peptide predicted for PMI3352 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.945 between residues 25 and 26 529507016550 Transcriptional regulator [Transcription]; Region: LysR; COG0583 529507016551 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507016552 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 529507016553 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix protei, score 1.1e-12 529507016554 PS00044 Bacterial regulatory proteins, lysR family signature. 529507016555 putative mechanosensitive channel protein; Provisional; Region: PRK10929 529507016556 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 529507016557 Mechanosensitive ion channel; Region: MS_channel; pfam00924 529507016558 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 4.5e-69 529507016559 11 probable transmembrane helices predicted for PMI3354 by TMHMM2.0 at aa 478-495, 525-547, 557-579, 600-622, 632-652, 673-695, 700-722, 786-805, 836-858, 878-900 and 910-932 529507016560 Signal peptide predicted for PMI3354 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24 529507016561 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 529507016562 HMMPfam hit to PF02666, Phosphatidylserine decarboxylase, score 1.3e-95 529507016563 GTPase RsgA; Reviewed; Region: PRK12288 529507016564 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 529507016565 RNA binding site [nucleotide binding]; other site 529507016566 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 529507016567 GTPase/Zn-binding domain interface [polypeptide binding]; other site 529507016568 GTP/Mg2+ binding site [chemical binding]; other site 529507016569 G4 box; other site 529507016570 G5 box; other site 529507016571 G1 box; other site 529507016572 Switch I region; other site 529507016573 G2 box; other site 529507016574 G3 box; other site 529507016575 Switch II region; other site 529507016576 HMMPfam hit to PF03193, Protein of unknown function, DUF258, score 8.5e-149 529507016577 PS00017 ATP/GTP-binding site motif A (P-loop). 529507016578 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 529507016579 catalytic site [active] 529507016580 putative active site [active] 529507016581 putative substrate binding site [chemical binding]; other site 529507016582 dimer interface [polypeptide binding]; other site 529507016583 HMMPfam hit to PF00929, Exonuclease, score 1.4e-33 529507016584 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 529507016585 HMMPfam hit to PF05016, Plasmid stabilisation system protein, score 2.7e-13 529507016586 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 529507016587 HMMPfam hit to PF02604, Phd_YefM, score 1.5e-15 529507016588 epoxyqueuosine reductase; Region: TIGR00276 529507016589 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 529507016590 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.0011 529507016591 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507016592 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 529507016593 HMMPfam hit to PF02367, Uncharacterised P-loop hydrolase UPF0079, score 5.1e-47 529507016594 PS00017 ATP/GTP-binding site motif A (P-loop). 529507016595 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 529507016596 AMIN domain; Region: AMIN; pfam11741 529507016597 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 529507016598 active site 529507016599 metal binding site [ion binding]; metal-binding site 529507016600 HMMPfam hit to PF01520, N-acetylmuramoyl-L-alanine amidase, score 2.9e-65 529507016601 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 529507016602 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 529507016603 ATP binding site [chemical binding]; other site 529507016604 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 529507016605 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and, score 2.6e-10 529507016606 PS00058 DNA mismatch repair proteins mutL / hexB / PMS1 signature. 529507016607 HMMPfam hit to PF01119, DNA mismatch repair protein, C-termina, score 1.4e-36 529507016608 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 529507016609 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 529507016610 PS00017 ATP/GTP-binding site motif A (P-loop). 529507016611 HMMPfam hit to PF01715, IPP transferase, score 7.8e-150 529507016612 bacterial Hfq-like; Region: Hfq; cd01716 529507016613 hexamer interface [polypeptide binding]; other site 529507016614 Sm1 motif; other site 529507016615 RNA binding site [nucleotide binding]; other site 529507016616 Sm2 motif; other site 529507016617 HMMPfam hit to PF01423, LSM domain, score 1.2e-11 529507016618 GTPase HflX; Provisional; Region: PRK11058 529507016619 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 529507016620 HflX GTPase family; Region: HflX; cd01878 529507016621 G1 box; other site 529507016622 GTP/Mg2+ binding site [chemical binding]; other site 529507016623 Switch I region; other site 529507016624 G2 box; other site 529507016625 G3 box; other site 529507016626 Switch II region; other site 529507016627 G4 box; other site 529507016628 G5 box; other site 529507016629 HMMPfam hit to PF01926, GTPase of unknown function, score 3.7e-39 529507016630 PS00017 ATP/GTP-binding site motif A (P-loop). 529507016631 FtsH protease regulator HflK; Provisional; Region: PRK10930 529507016632 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 529507016633 1 probable transmembrane helix predicted for PMI3367 by TMHMM2.0 at aa 80-102 529507016634 HMMPfam hit to PF01145, SPFH domain / Band, score 6.4e-43 529507016635 FtsH protease regulator HflC; Provisional; Region: PRK11029 529507016636 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 529507016637 Signal peptide predicted for PMI3368 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.656 between residues 22 and 23 529507016638 1 probable transmembrane helix predicted for PMI3368 by TMHMM2.0 at aa 5-24 529507016639 HMMPfam hit to PF01145, SPFH domain / Band, score 5.1e-57 529507016640 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 529507016641 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 529507016642 GDP-binding site [chemical binding]; other site 529507016643 ACT binding site; other site 529507016644 IMP binding site; other site 529507016645 HMMPfam hit to PF00709, Adenylosuccinate synthetase, score 0 529507016646 PS01266 Adenylosuccinate synthetase GTP-binding site. 529507016647 PS00513 Adenylosuccinate synthetase active site. 529507016648 Predicted transcriptional regulator [Transcription]; Region: COG1959 529507016649 transcriptional repressor NsrR; Provisional; Region: PRK11014 529507016650 HMMPfam hit to PF02082, Transcriptional regulator, score 2.8e-40 529507016651 exoribonuclease R; Provisional; Region: PRK11642 529507016652 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 529507016653 RNB domain; Region: RNB; pfam00773 529507016654 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 529507016655 RNA binding site [nucleotide binding]; other site 529507016656 HMMPfam hit to PF00773, RNB-like protein, score 1.9e-137 529507016657 PS01175 Ribonuclease II family signature. 529507016658 HMMPfam hit to PF00575, S1 RNA binding domain, score 7.4e-21 529507016659 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 529507016660 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 529507016661 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 529507016662 HMMPfam hit to PF00588, SpoU rRNA Methylase family, score 1.7e-66 529507016663 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 529507016664 HMMPfam hit to PF01250, Ribosomal protein S6, score 3.8e-50 529507016665 PS01048 Ribosomal protein S6 signature. 529507016666 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 529507016667 dimer interface [polypeptide binding]; other site 529507016668 ssDNA binding site [nucleotide binding]; other site 529507016669 tetramer (dimer of dimers) interface [polypeptide binding]; other site 529507016670 HMMPfam hit to PF00436, Single-strand binding protein family, score 9.6e-18 529507016671 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 529507016672 HMMPfam hit to PF01084, Ribosomal protein S18, score 1.2e-32 529507016673 PS00057 Ribosomal protein S18 signature. 529507016674 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 529507016675 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 529507016676 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 529507016677 HMMPfam hit to PF01281, Ribosomal protein L9, N-terminal domai, score 1.1e-28 529507016678 PS00651 Ribosomal protein L9 signature. 529507016679 HMMPfam hit to PF03948, Ribosomal protein L9, C-terminal domai, score 7.3e-40 529507016680 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 529507016681 1 probable transmembrane helix predicted for PMI3378 by TMHMM2.0 at aa 39-56 529507016682 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 529507016683 HMMPfam hit to PF01197, Ribosomal protein L31, score 1.5e-11 529507016684 zinc/cadmium-binding protein; Provisional; Region: PRK10306 529507016685 Signal peptide predicted for PMI3380 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.773 between residues 23 and 24 529507016686 Transposase IS200 like; Region: Y1_Tnp; pfam01797 529507016687 HMMPfam hit to PF01797, Transposase IS200 like, score 4.4e-43 529507016688 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507016689 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 529507016690 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 529507016691 Probable transposase; Region: OrfB_IS605; pfam01385 529507016692 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 529507016693 HMMPfam hit to PF01385, Probable transposase, score 3.7e-131 529507016694 HMMPfam hit to PF07282, transposase DNA-binding domai, score 3e-34 529507016695 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507016696 succinic semialdehyde dehydrogenase; Region: PLN02278 529507016697 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 529507016698 tetramerization interface [polypeptide binding]; other site 529507016699 NAD(P) binding site [chemical binding]; other site 529507016700 catalytic residues [active] 529507016701 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 1.7e-213 529507016702 PS00070 Aldehyde dehydrogenases cysteine active site. 529507016703 PS00687 Aldehyde dehydrogenases glutamic acid active site. 529507016704 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 529507016705 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 529507016706 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 529507016707 HMMPfam hit to PF01346, Domain amino terminal to FKBP-type peptidyl-, score 2.4e-06 529507016708 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 1.5e-44 529507016709 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 529507016710 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 529507016711 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 529507016712 active site 529507016713 HMMPfam hit to PF00459, Inositol monophosphatase family, score 2.3e-71 529507016714 PS00629 Inositol monophosphatase family signature 1. 529507016715 PS00630 Inositol monophosphatase family signature 2. 529507016716 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 529507016717 Signal peptide predicted for PMI3386 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.934 between residues 19 and 20 529507016718 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 529507016719 HMMPfam hit to PF06526, Protein of unknown function (DUF1107), score 4.1e-37 529507016720 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 529507016721 Domain of unknown function DUF21; Region: DUF21; pfam01595 529507016722 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 529507016723 Transporter associated domain; Region: CorC_HlyC; smart01091 529507016724 HMMPfam hit to PF03471, Transporter associated domain, score 7e-23 529507016725 HMMPfam hit to PF00571, CBS domain, score 0.0028 529507016726 HMMPfam hit to PF00571, CBS domain, score 1.1e-06 529507016727 HMMPfam hit to PF01595, Domain of unknown function DUF21, score 7.5e-65 529507016728 4 probable transmembrane helices predicted for PMI3388 by TMHMM2.0 at aa 5-27, 53-75, 95-117 and 144-161 529507016729 Signal peptide predicted for PMI3388 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.668 between residues 26 and 27 529507016730 methionine sulfoxide reductase A; Provisional; Region: PRK00058 529507016731 HMMPfam hit to PF01625, Peptide methionine sulfoxide reductase, score 7.8e-98 529507016732 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 529507016733 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 529507016734 Surface antigen; Region: Bac_surface_Ag; pfam01103 529507016735 Signal peptide predicted for PMI3390 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.710 between residues 21 and 22 529507016736 HMMPfam hit to PF01103, Surface antigen, score 6e-76 529507016737 PS00213 Lipocalin signature. 529507016738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 529507016739 Dicarboxylate transport; Region: DctA-YdbH; cl14674 529507016740 Family of unknown function (DUF490); Region: DUF490; pfam04357 529507016741 Signal peptide predicted for PMI3391 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.737 between residues 23 and 24 529507016742 HMMPfam hit to PF04357, Family of unknown function (DUF490), score 1.1e-151 529507016743 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 529507016744 putative active site pocket [active] 529507016745 dimerization interface [polypeptide binding]; other site 529507016746 putative catalytic residue [active] 529507016747 HMMPfam hit to PF03674, Uncharacterised protein family (UPF0131), score 1.9e-29 529507016748 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 529507016749 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 529507016750 Major Facilitator Superfamily; Region: MFS_1; pfam07690 529507016751 Signal peptide predicted for PMI3395 by SignalP 2.0 HMM (Signal peptide probability 0.650) with cleavage site probability 0.207 between residues 29 and 30 529507016752 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 9.6e-19 529507016753 12 probable transmembrane helices predicted for PMI3395 by TMHMM2.0 at aa 5-27, 37-59, 66-88, 93-115, 136-155, 159-181, 202-221, 248-270, 277-296, 300-322, 334-356 and 366-388 529507016754 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 529507016755 dimer interface [polypeptide binding]; other site 529507016756 substrate binding site [chemical binding]; other site 529507016757 metal binding sites [ion binding]; metal-binding site 529507016758 HMMPfam hit to PF00719, Inorganic pyrophosphatase, score 3.2e-61 529507016759 PS00387 Inorganic pyrophosphatase signature. 529507016760 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 529507016761 AMP binding site [chemical binding]; other site 529507016762 metal binding site [ion binding]; metal-binding site 529507016763 active site 529507016764 HMMPfam hit to PF00316, Fructose-1-6-bisphosphatase, score 5.3e-200 529507016765 PS00124 Fructose-1-6-bisphosphatase active site. 529507016766 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 529507016767 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 529507016768 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 529507016769 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 529507016770 Signal peptide predicted for PMI3398 by SignalP 2.0 HMM (Signal peptide probability 0.756) with cleavage site probability 0.554 between residues 20 and 21 529507016771 HMMPfam hit to PF01225, Mur ligase family, catalytic domain, score 3.7e-57 529507016772 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 5.6e-19 529507016773 arginine repressor; Provisional; Region: PRK05066 529507016774 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 529507016775 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 529507016776 HMMPfam hit to PF02863, Arginine repressor, C-terminal domain, score 2.6e-23 529507016777 HMMPfam hit to PF01316, Arginine repressor, DNA binding domai, score 6.1e-31 529507016778 malate dehydrogenase; Provisional; Region: PRK05086 529507016779 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 529507016780 NAD binding site [chemical binding]; other site 529507016781 dimerization interface [polypeptide binding]; other site 529507016782 Substrate binding site [chemical binding]; other site 529507016783 HMMPfam hit to PF00056, lactate/malate dehydrogenase, NAD binding do, score 2e-71 529507016784 PS00068 Malate dehydrogenase active site signature. 529507016785 HMMPfam hit to PF02866, lactate/malate dehydrogenase, alpha/beta C-t, score 6.3e-63 529507016786 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 529507016787 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 529507016788 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 529507016789 HMMPfam hit to PF02316, Mu DNA-binding domain, score 1.2e-05 529507016790 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 529507016791 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 529507016792 substrate binding pocket [chemical binding]; other site 529507016793 chain length determination region; other site 529507016794 substrate-Mg2+ binding site; other site 529507016795 catalytic residues [active] 529507016796 aspartate-rich region 1; other site 529507016797 active site lid residues [active] 529507016798 aspartate-rich region 2; other site 529507016799 HMMPfam hit to PF00348, Polyprenyl synthetase, score 5.3e-114 529507016800 PS00444 Polyprenyl synthetases signature 2. 529507016801 PS00723 Polyprenyl synthetases signature 1. 529507016802 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 529507016803 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 529507016804 HMMPfam hit to PF00829, Ribosomal prokaryotic L21 protein, score 1.2e-58 529507016805 PS01169 Ribosomal protein L21 signature. 529507016806 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 529507016807 HMMPfam hit to PF01016, Ribosomal L27 protein, score 7.2e-59 529507016808 PS00831 Ribosomal protein L27 signature. 529507016809 GTPase CgtA; Reviewed; Region: obgE; PRK12298 529507016810 GTP1/OBG; Region: GTP1_OBG; pfam01018 529507016811 Obg GTPase; Region: Obg; cd01898 529507016812 G1 box; other site 529507016813 GTP/Mg2+ binding site [chemical binding]; other site 529507016814 Switch I region; other site 529507016815 G2 box; other site 529507016816 G3 box; other site 529507016817 Switch II region; other site 529507016818 G4 box; other site 529507016819 G5 box; other site 529507016820 HMMPfam hit to PF01018, GTP1/OBG, score 1.3e-92 529507016821 HMMPfam hit to PF01926, GTPase of unknown function, score 3.4e-37 529507016822 PS00017 ATP/GTP-binding site motif A (P-loop). 529507016823 PS00905 GTP1/OBG family signature. 529507016824 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 529507016825 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 529507016826 HMMPfam hit to PF02113, D-Ala-D-Ala carboxypeptidase 3 (S13) fa, score 1.6e-167 529507016827 Signal peptide predicted for PMI3408 by SignalP 2.0 HMM (Signal peptide probability 0.970) with cleavage site probability 0.964 between residues 23 and 24 529507016828 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 529507016829 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 529507016830 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 529507016831 HMMPfam hit to PF03449, Prokaryotic transcription elongation fact, score 2.1e-46 529507016832 PS00829 Prokaryotic transcription elongation factors signature 1. 529507016833 HMMPfam hit to PF01272, Prokaryotic transcription elongation fact, score 1.4e-44 529507016834 PS00830 Prokaryotic transcription elongation factors signature 2. 529507016835 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 529507016836 HMMPfam hit to PF01985, CRS1 / YhbY domain, score 2.7e-34 529507016837 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 529507016838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507016839 S-adenosylmethionine binding site [chemical binding]; other site 529507016840 HMMPfam hit to PF01728, FtsJ-like methyltransferase, score 2.3e-78 529507016841 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 529507016842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 529507016843 Walker A motif; other site 529507016844 ATP binding site [chemical binding]; other site 529507016845 Walker B motif; other site 529507016846 arginine finger; other site 529507016847 Peptidase family M41; Region: Peptidase_M41; pfam01434 529507016848 Signal peptide predicted for PMI3412 by SignalP 2.0 HMM (Signal peptide probability 0.943) with cleavage site probability 0.468 between residues 23 and 24 529507016849 2 probable transmembrane helices predicted for PMI3412 by TMHMM2.0 at aa 5-24 and 97-119 529507016850 HMMPfam hit to PF06480, FtsH Extracellular, score 7.8e-45 529507016851 PS00017 ATP/GTP-binding site motif A (P-loop). 529507016852 HMMPfam hit to PF00004, ATPase family associated with various c, score 4.6e-98 529507016853 PS00017 ATP/GTP-binding site motif A (P-loop). 529507016854 PS00674 AAA-protein family signature. 529507016855 HMMPfam hit to PF01434, Peptidase family M41, score 2.6e-127 529507016856 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 529507016857 dihydropteroate synthase; Region: DHPS; TIGR01496 529507016858 substrate binding pocket [chemical binding]; other site 529507016859 dimer interface [polypeptide binding]; other site 529507016860 inhibitor binding site; inhibition site 529507016861 PS00792 Dihydropteroate synthase signature 1. 529507016862 HMMPfam hit to PF00809, Pterin binding enzyme, score 8.8e-101 529507016863 PS00793 Dihydropteroate synthase signature 2. 529507016864 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 529507016865 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 529507016866 active site 529507016867 substrate binding site [chemical binding]; other site 529507016868 metal binding site [ion binding]; metal-binding site 529507016869 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase, al, score 7.5e-60 529507016870 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 529507016871 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase, al, score 1.9e-44 529507016872 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase, al, score 1.6e-41 529507016873 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase, C-, score 2.5e-12 529507016874 Preprotein translocase SecG subunit; Region: SecG; pfam03840 529507016875 HMMPfam hit to PF03840, Preprotein translocase SecG subunit, score 1.5e-32 529507016876 2 probable transmembrane helices predicted for PMI3415 by TMHMM2.0 at aa 5-22 and 51-73 529507016877 ribosome maturation protein RimP; Reviewed; Region: PRK00092 529507016878 Sm and related proteins; Region: Sm_like; cl00259 529507016879 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 529507016880 putative oligomer interface [polypeptide binding]; other site 529507016881 putative RNA binding site [nucleotide binding]; other site 529507016882 HMMPfam hit to PF02576, Uncharacterised BCR, YhbC family COG0779, score 3.7e-66 529507016883 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 529507016884 NusA N-terminal domain; Region: NusA_N; pfam08529 529507016885 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 529507016886 RNA binding site [nucleotide binding]; other site 529507016887 homodimer interface [polypeptide binding]; other site 529507016888 NusA-like KH domain; Region: KH_5; pfam13184 529507016889 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 529507016890 G-X-X-G motif; other site 529507016891 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 529507016892 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 529507016893 HMMPfam hit to PF00575, S1 RNA binding domain, score 4.4e-13 529507016894 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 529507016895 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 529507016896 translation initiation factor IF-2; Region: IF-2; TIGR00487 529507016897 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 529507016898 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 529507016899 G1 box; other site 529507016900 putative GEF interaction site [polypeptide binding]; other site 529507016901 GTP/Mg2+ binding site [chemical binding]; other site 529507016902 Switch I region; other site 529507016903 G2 box; other site 529507016904 G3 box; other site 529507016905 Switch II region; other site 529507016906 G4 box; other site 529507016907 G5 box; other site 529507016908 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 529507016909 Translation-initiation factor 2; Region: IF-2; pfam11987 529507016910 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 529507016911 HMMPfam hit to PF04760, Translation initiation factor IF-2, N-ter, score 1.7e-10 529507016912 HMMPfam hit to PF04760, Translation initiation factor IF-2, N-ter, score 1.3e-21 529507016913 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 3.5e-54 529507016914 HMMPfam hit to PF01926, GTPase of unknown function, score 1.7e-07 529507016915 PS00017 ATP/GTP-binding site motif A (P-loop). 529507016916 HMMPfam hit to PF03144, Elongation factor Tu domain, score 3.2e-12 529507016917 HMMPfam hit to PF03144, Elongation factor Tu domain, score 2.1e-10 529507016918 PS01176 Initiation factor 2 signature. 529507016919 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 529507016920 HMMPfam hit to PF02033, Ribosome-binding factor A, score 2.3e-54 529507016921 PS01319 Ribosome-binding factor A signature. 529507016922 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 529507016923 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 529507016924 RNA binding site [nucleotide binding]; other site 529507016925 active site 529507016926 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 529507016927 HMMPfam hit to PF01509, TruB family pseudouridylate synthase (N term, score 1.2e-89 529507016928 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 529507016929 16S/18S rRNA binding site [nucleotide binding]; other site 529507016930 S13e-L30e interaction site [polypeptide binding]; other site 529507016931 25S rRNA binding site [nucleotide binding]; other site 529507016932 HMMPfam hit to PF00312, Ribosomal protein S15, score 4.1e-43 529507016933 PS00362 Ribosomal protein S15 signature. 529507016934 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 529507016935 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 529507016936 RNase E interface [polypeptide binding]; other site 529507016937 trimer interface [polypeptide binding]; other site 529507016938 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 529507016939 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 529507016940 RNase E interface [polypeptide binding]; other site 529507016941 trimer interface [polypeptide binding]; other site 529507016942 active site 529507016943 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 529507016944 putative nucleic acid binding region [nucleotide binding]; other site 529507016945 G-X-X-G motif; other site 529507016946 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 529507016947 RNA binding site [nucleotide binding]; other site 529507016948 domain interface; other site 529507016949 HMMPfam hit to PF01138, 3' exoribonuclease family, domain, score 2e-42 529507016950 HMMPfam hit to PF03725, 3' exoribonuclease family, domain, score 1.7e-18 529507016951 HMMPfam hit to PF03726, Polyribonucleotide nucleotidyltransferase,, score 2.3e-33 529507016952 HMMPfam hit to PF01138, 3' exoribonuclease family, domain, score 1.7e-53 529507016953 HMMPfam hit to PF03725, 3' exoribonuclease family, domain, score 5.6e-21 529507016954 HMMPfam hit to PF00013, KH domain, score 2.4e-16 529507016955 HMMPfam hit to PF07650, KH domain, score 0.014 529507016956 HMMPfam hit to PF00575, S1 RNA binding domain, score 1.6e-27 529507016957 lipoprotein NlpI; Provisional; Region: PRK11189 529507016958 signal peptide predicted for PMI3423 by SignalP 2.0 HMM (Signal peptide probability 0.880) with cleavage site probability 0.421 between residues 21 and 22 529507016959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 529507016960 binding surface 529507016961 TPR motif; other site 529507016962 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507016963 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.24; HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.001 529507016964 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.0004; HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.021 529507016965 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.075; HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.24 529507016966 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.37; HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.46 529507016967 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 529507016968 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 529507016969 ATP binding site [chemical binding]; other site 529507016970 Mg++ binding site [ion binding]; other site 529507016971 motif III; other site 529507016972 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 529507016973 nucleotide binding region [chemical binding]; other site 529507016974 ATP-binding site [chemical binding]; other site 529507016975 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 529507016976 putative RNA binding site [nucleotide binding]; other site 529507016977 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 6.2e-73 529507016978 PS00017 ATP/GTP-binding site motif A (P-loop). 529507016979 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 529507016980 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 3.5e-34 529507016981 HMMPfam hit to PF03880, DbpA RNA binding domain, score 3.1e-38 529507016982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 529507016983 YheO-like PAS domain; Region: PAS_6; pfam08348 529507016984 HTH domain; Region: HTH_22; pfam13309 529507016985 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 529507016986 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 529507016987 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 1.1e-30 529507016988 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 529507016989 homotrimer interaction site [polypeptide binding]; other site 529507016990 putative active site [active] 529507016991 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 9.5e-53 529507016992 PS01094 Uncharacterized protein family UPF0076 signature. 529507016993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507016994 putative substrate translocation pore; other site 529507016995 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 529507016996 12 probable transmembrane helices predicted for PMI3428 by TMHMM2.0 at aa 9-31, 44-66, 73-90, 95-117, 137-159, 169-188, 219-241, 246-265, 285-307, 312-334, 347-369 and 384-403 529507016997 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.5e-22 529507016998 hypothetical protein; Provisional; Region: PRK10039 529507016999 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 529507017000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507017001 active site 529507017002 phosphorylation site [posttranslational modification] 529507017003 intermolecular recognition site; other site 529507017004 dimerization interface [polypeptide binding]; other site 529507017005 LytTr DNA-binding domain; Region: LytTR; pfam04397 529507017006 HMMPfam hit to PF04397, LytTr DNA-binding domain, score 1.2e-23 529507017007 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.2e-37 529507017008 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 529507017009 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 529507017010 GAF domain; Region: GAF; pfam01590 529507017011 Histidine kinase; Region: His_kinase; pfam06580 529507017012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 529507017013 ATP binding site [chemical binding]; other site 529507017014 Mg2+ binding site [ion binding]; other site 529507017015 G-X-G motif; other site 529507017016 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 4e-08 529507017017 HMMPfam hit to PF06580, Histidine kinase, score 8.2e-39 529507017018 HMMPfam hit to PF01590, GAF domain, score 1.4e-05 529507017019 6 probable transmembrane helices predicted for PMI3431 by TMHMM2.0 at aa 7-24, 44-63, 75-97, 102-124, 137-159 and 174-194 529507017020 HMMPfam hit to PF07694, 5TMR of 5TMR-LYT, score 2.6e-41 529507017021 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 529507017022 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 529507017023 HlyD family secretion protein; Region: HlyD_3; pfam13437 529507017024 Signal peptide predicted for PMI3432 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.461 between residues 19 and 20 529507017025 1 probable transmembrane helix predicted for PMI3432 by TMHMM2.0 at aa 5-22 529507017026 HMMPfam hit to PF00529, HlyD family secretion protein, score 0.00014 529507017027 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 529507017028 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 529507017029 6 probable transmembrane helices predicted for PMI3433 by TMHMM2.0 at aa 21-43, 189-211, 224-246, 261-283, 288-310 and 344-366 529507017030 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 529507017031 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 529507017032 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 529507017033 Signal peptide predicted for PMI3434 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.989 between residues 37 and 38 529507017034 6 probable transmembrane helices predicted for PMI3434 by TMHMM2.0 at aa 20-42, 181-203, 216-238, 253-270, 283-305 and 341-363 529507017035 HMMPfam hit to PF01061, ABC-2 type transporter, score 7.5e-05 529507017036 Fimbrial protein; Region: Fimbrial; cl01416 529507017037 Signal peptide predicted for PMI3435 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.544 between residues 24 and 25 529507017038 HMMPfam hit to PF00419, Fimbrial protein, score 5.9e-51 529507017039 fimbrial operon 17 529507017040 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 529507017041 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 529507017042 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 529507017043 Signal peptide predicted for PMI3436 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 28 and 29 529507017044 1 probable transmembrane helix predicted for PMI3436 by TMHMM2.0 at aa 12-34 529507017045 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 2.7e-52 529507017046 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 6.6e-21 529507017047 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 529507017048 PapC N-terminal domain; Region: PapC_N; pfam13954 529507017049 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 529507017050 PapC C-terminal domain; Region: PapC_C; pfam13953 529507017051 Signal peptide predicted for PMI3437 by SignalP 2.0 HMM (Signal peptide probability 0.608) with cleavage site probability 0.306 between residues 35 and 36 529507017052 HMMPfam hit to PF00577, Fimbrial Usher protein, score 0 529507017053 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507017054 Signal peptide predicted for PMI3438 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.978 between residues 26 and 27 529507017055 HMMPfam hit to PF00419, Fimbrial protein, score 2.7e-22 529507017056 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 529507017057 Signal peptide predicted for PMI3439 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 25 and 26 529507017058 HMMPfam hit to PF00419, Fimbrial protein, score 1.9e-06 529507017059 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 529507017060 mannosyl binding site [chemical binding]; other site 529507017061 Fimbrial protein; Region: Fimbrial; pfam00419 529507017062 Signal peptide predicted for PMI3440 by SignalP 2.0 HMM (Signal peptide probability 0.979) with cleavage site probability 0.602 between residues 25 and 26 529507017063 HMMPfam hit to PF00419, Fimbrial protein, score 3.2e-05 529507017064 putative protease; Provisional; Region: PRK15447 529507017065 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 529507017066 HMMPfam hit to PF01136, Peptidase family U32, score 3.4e-07 529507017067 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 529507017068 Peptidase family U32; Region: Peptidase_U32; pfam01136 529507017069 HMMPfam hit to PF01136, Peptidase family U32, score 1.3e-118 529507017070 PS01276 Peptidase family U32 signature. 529507017071 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 529507017072 HMMPfam hit to PF02036, SCP-2 sterol transfer family, score 2.7e-14 529507017073 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 529507017074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 529507017075 Coenzyme A binding pocket [chemical binding]; other site 529507017076 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 7.9e-15 529507017077 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 529507017078 GIY-YIG motif/motif A; other site 529507017079 putative active site [active] 529507017080 putative metal binding site [ion binding]; other site 529507017081 HMMPfam hit to PF01541, GIY-YIG catalytic domain, score 1.8e-16 529507017082 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 529507017083 HMMPfam hit to PF07338, Protein of unknown function (DUF1471), score 1.3e-06 529507017084 Signal peptide predicted for PMI3446 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.964 between residues 22 and 23 529507017085 hypothetical protein; Provisional; Region: PRK03467 529507017086 Signal peptide predicted for PMI3448 by SignalP 2.0 HMM (Signal peptide probability 0.673) with cleavage site probability 0.433 between residues 19 and 20 529507017087 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507017088 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 529507017089 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 529507017090 FeS/SAM binding site; other site 529507017091 PS01087 Radical activating enzymes signature. 529507017092 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 529507017093 ATP cone domain; Region: ATP-cone; pfam03477 529507017094 Class III ribonucleotide reductase; Region: RNR_III; cd01675 529507017095 effector binding site; other site 529507017096 active site 529507017097 Zn binding site [ion binding]; other site 529507017098 glycine loop; other site 529507017099 HMMPfam hit to PF01228, Glycine radical, score 8.1e-49 529507017100 PS00850 Glycine radical signature. 529507017101 HMMPfam hit to PF03477, ATP cone domain, score 9.6e-26 529507017102 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 529507017103 homotrimer interaction site [polypeptide binding]; other site 529507017104 putative active site [active] 529507017105 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 2.4e-64 529507017106 PS01094 Uncharacterized protein family UPF0076 signature. 529507017107 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 529507017108 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 529507017109 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 529507017110 HMMPfam hit to PF02748, Aspartate carbamoyltransferase regulatory ch, score 1.6e-15 529507017111 HMMPfam hit to PF01948, Aspartate carbamoyltransferase regulatory ch, score 1.4e-55 529507017112 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 529507017113 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 529507017114 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 529507017115 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, As, score 1.8e-57 529507017116 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, ca, score 1.2e-68 529507017117 PS00097 Aspartate and ornithine carbamoyltransferases signature. 529507017118 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 529507017119 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 529507017120 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 529507017121 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, As, score 4.6e-91 529507017122 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, ca, score 7.6e-74 529507017123 PS00097 Aspartate and ornithine carbamoyltransferases signature. 529507017124 RNase E inhibitor protein; Provisional; Region: PRK11191 529507017125 HMMPfam hit to PF06877, Protein of unknown function (DUF1260), score 5.9e-76 529507017126 Pirin-related protein [General function prediction only]; Region: COG1741 529507017127 Pirin; Region: Pirin; pfam02678 529507017128 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 529507017129 HMMPfam hit to PF05726, Pirin C-terminal region, score 6.1e-37 529507017130 HMMPfam hit to PF02678, Pirin, score 4.4e-44 529507017131 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 529507017132 Signal peptide predicted for PMI3460 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.960 between residues 26 and 27 529507017133 1 probable transmembrane helix predicted for PMI3460 by TMHMM2.0 at aa 7-25 529507017134 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507017135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 529507017136 Coenzyme A binding pocket [chemical binding]; other site 529507017137 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 3.9e-20 529507017138 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 529507017139 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 529507017140 HIGH motif; other site 529507017141 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 529507017142 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 529507017143 active site 529507017144 KMSKS motif; other site 529507017145 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 529507017146 tRNA binding surface [nucleotide binding]; other site 529507017147 anticodon binding site; other site 529507017148 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 529507017149 HMMPfam hit to PF00133, tRNA synthetases class I (I, L, M and V), score 0 529507017150 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 529507017151 DNA polymerase III subunit chi; Validated; Region: PRK05728 529507017152 HMMPfam hit to PF04364, DNA polymerase III chi subunit, HolC, score 1.6e-65 529507017153 multifunctional aminopeptidase A; Provisional; Region: PRK00913 529507017154 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 529507017155 interface (dimer of trimers) [polypeptide binding]; other site 529507017156 Substrate-binding/catalytic site; other site 529507017157 Zn-binding sites [ion binding]; other site 529507017158 HMMPfam hit to PF00883, Cytosol aminopeptidase family, cataly, score 1.3e-196 529507017159 PS00631 Cytosol aminopeptidase signature. 529507017160 HMMPfam hit to PF02789, Cytosol aminopeptidase family, N-term, score 8.8e-51 529507017161 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 529507017162 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 529507017163 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ family, score 1.9e-70 529507017164 6 probable transmembrane helices predicted for PMI3465 by TMHMM2.0 at aa 17-39, 59-81, 101-123, 267-289, 296-313 and 328-347 529507017165 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 529507017166 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 529507017167 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ family, score 3.2e-94 529507017168 6 probable transmembrane helices predicted for PMI3466 by TMHMM2.0 at aa 12-34, 62-81, 102-124, 277-296, 303-320 and 330-352 529507017169 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 529507017170 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 529507017171 HMMPfam hit to PF00144, Beta-lactamase, score 7.3e-54 529507017172 prophage/mobile element 529507017173 integrase; Provisional; Region: PRK09692 529507017174 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 529507017175 active site 529507017176 Int/Topo IB signature motif; other site 529507017177 HMMPfam hit to PF00589, Phage integrase family, score 1.5e-39 529507017178 phage integrase (fragment) 529507017179 3 probable transmembrane helices predicted for PMI3471 by TMHMM2.0 at aa 163-180, 193-215 and 220-239 529507017180 1 probable transmembrane helix predicted for PMI3472 by TMHMM2.0 at aa 4-26 529507017181 1 probable transmembrane helix predicted for PMI3473 by TMHMM2.0 at aa 10-29 529507017182 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 529507017183 2 probable transmembrane helices predicted for PMI3475 by TMHMM2.0 at aa 288-310 and 374-393 529507017184 2 probable transmembrane helices predicted for PMI3476 by TMHMM2.0 at aa 12-31 and 79-101 529507017185 conserved hypothetical protein (fragment) 529507017186 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 529507017187 HMMPfam hit to PF05930, Prophage CP4-57 regulatory protein (AlpA), score 1e-20 529507017188 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 529507017189 Predicted GTPase [General function prediction only]; Region: COG3596 529507017190 YfjP GTPase; Region: YfjP; cd11383 529507017191 G1 box; other site 529507017192 GTP/Mg2+ binding site [chemical binding]; other site 529507017193 Switch I region; other site 529507017194 G2 box; other site 529507017195 Switch II region; other site 529507017196 G3 box; other site 529507017197 G4 box; other site 529507017198 G5 box; other site 529507017199 HMMPfam hit to PF01926, GTPase of unknown function, score 1.1e-23 529507017200 PS00017 ATP/GTP-binding site motif A (P-loop). 529507017201 Antirestriction protein; Region: Antirestrict; pfam03230 529507017202 HMMPfam hit to PF03230, Antirestriction protein, score 1.5e-36 529507017203 Domain of unknown function (DUF932); Region: DUF932; pfam06067 529507017204 HMMPfam hit to PF06067, Domain of unknown function (DUF932), score 6.8e-202 529507017205 HTH domain; Region: HTH_11; cl17392 529507017206 WYL domain; Region: WYL; pfam13280 529507017207 Signal peptide predicted for PMI3484 by SignalP 2.0 HMM (Signal peptide probability 0.927) with cleavage site probability 0.851 between residues 34 and 35 529507017208 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 529507017209 4 probable transmembrane helices predicted for PMI3486 by TMHMM2.0 at aa 16-38, 53-75, 88-110 and 120-139 529507017210 Signal peptide predicted for PMI3487 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.936 between residues 22 and 23 529507017211 Signal peptide predicted for PMI3490 by SignalP 2.0 HMM (Signal peptide probability 0.977) with cleavage site probability 0.630 between residues 21 and 22 529507017212 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 529507017213 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 529507017214 Domain of unknown function (DUF955); Region: DUF955; pfam06114 529507017215 HMMPfam hit to PF06114, Domain of unknown function (DUF955), score 7.7e-08 529507017216 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 529507017217 Beta protein; Region: Beta_protein; pfam14350 529507017218 conserved hypothetical protein (pseudogene) 529507017219 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 529507017220 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 529507017221 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507017222 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 529507017223 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 529507017224 active site 529507017225 Transposase IS200 like; Region: Y1_Tnp; pfam01797 529507017226 HMMPfam hit to PF01797, Transposase IS200 like, score 3.5e-42 529507017227 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507017228 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 529507017229 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 529507017230 Probable transposase; Region: OrfB_IS605; pfam01385 529507017231 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 529507017232 HMMPfam hit to PF01385, Probable transposase, score 4.1e-125 529507017233 HMMPfam hit to PF07282, transposase DNA-binding domai, score 3e-34 529507017234 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507017235 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 529507017236 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507017237 non-specific DNA binding site [nucleotide binding]; other site 529507017238 salt bridge; other site 529507017239 sequence-specific DNA binding site [nucleotide binding]; other site 529507017240 HMMPfam hit to PF01381, Helix-turn-helix, score 1.3e-09 529507017241 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 529507017242 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 529507017243 HMMPfam hit to PF00472, Peptidyl-tRNA hydrolase domain, score 8.6e-18 529507017244 PS00745 Prokaryotic-type class I peptide chain release factors signature. 529507017245 hypothetical protein; Reviewed; Region: PRK09588 529507017246 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 529507017247 HMMPfam hit to PF01139, Uncharacterized protein family UPF0027, score 1.8e-93 529507017248 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 529507017249 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 529507017250 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 529507017251 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 2.3e-36 529507017252 PS00894 Bacterial regulatory proteins, deoR family signature. 529507017253 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 529507017254 intersubunit interface [polypeptide binding]; other site 529507017255 active site 529507017256 catalytic residue [active] 529507017257 HMMPfam hit to PF01791, Deoxyribose-phosphate aldolase, score 6e-86 529507017258 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 529507017259 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 529507017260 substrate binding site [chemical binding]; other site 529507017261 dimer interface [polypeptide binding]; other site 529507017262 ATP binding site [chemical binding]; other site 529507017263 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 6e-67 529507017264 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 529507017265 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 529507017266 putative active site [active] 529507017267 HMMPfam hit to PF01380, SIS domain, score 0.0023 529507017268 PS01272 Glucokinase regulatory protein family signature. 529507017269 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 529507017270 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 529507017271 active site turn [active] 529507017272 phosphorylation site [posttranslational modification] 529507017273 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 529507017274 HMMPfam hit to PF00367, phosphotransferase system, EIIB, score 2.9e-07 529507017275 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 529507017276 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 5.4e-30 529507017277 10 probable transmembrane helices predicted for PMI3515 by TMHMM2.0 at aa 117-139, 159-176, 183-205, 215-237, 244-266, 281-303, 323-345, 360-382, 389-411 and 426-448 529507017278 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 529507017279 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 529507017280 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 529507017281 putative active site [active] 529507017282 HMMPfam hit to PF01418, Helix-turn-helix domain, rpiR family, score 6.5e-34 529507017283 HMMPfam hit to PF01380, SIS domain, score 1.3e-26 529507017284 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 529507017285 Signal peptide predicted for PMI3517 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.323 between residues 45 and 46 529507017286 8 probable transmembrane helices predicted for PMI3517 by TMHMM2.0 at aa 4-26, 31-53, 73-95, 107-129, 154-176, 181-203, 213-235 and 242-259 529507017287 HMMPfam hit to PF01925, Domain of unknown function DUF81, score 3.7e-23 529507017288 1 probable transmembrane helix predicted for PMI3518 by TMHMM2.0 at aa 7-29 529507017289 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 529507017290 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 529507017291 PYR/PP interface [polypeptide binding]; other site 529507017292 dimer interface [polypeptide binding]; other site 529507017293 TPP binding site [chemical binding]; other site 529507017294 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 529507017295 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 529507017296 TPP-binding site [chemical binding]; other site 529507017297 dimer interface [polypeptide binding]; other site 529507017298 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 2.8e-97 529507017299 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 1.7e-61 529507017300 PS00187 Thiamine pyrophosphate enzymes signature. 529507017301 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 529507017302 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 529507017303 putative valine binding site [chemical binding]; other site 529507017304 dimer interface [polypeptide binding]; other site 529507017305 HMMPfam hit to PF01842, ACT domain, score 4.2e-07 529507017306 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 529507017307 HMMPfam hit to PF01545, Cation efflux family, score 3.3e-95 529507017308 6 probable transmembrane helices predicted for PMI3521 by TMHMM2.0 at aa 23-45, 55-74, 87-109, 124-141, 162-184 and 189-206 529507017309 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 529507017310 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507017311 non-specific DNA binding site [nucleotide binding]; other site 529507017312 salt bridge; other site 529507017313 sequence-specific DNA binding site [nucleotide binding]; other site 529507017314 Cupin domain; Region: Cupin_2; cl17218 529507017315 HMMPfam hit to PF07883, Cupin domain, score 0.00036 529507017316 HMMPfam hit to PF01381, Helix-turn-helix, score 4.9e-17 529507017317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507017318 Major Facilitator Superfamily; Region: MFS_1; pfam07690 529507017319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507017320 12 probable transmembrane helices predicted for PMI3523 by TMHMM2.0 at aa 12-34, 49-71, 78-100, 104-126, 138-160, 165-182, 201-223, 233-255, 275-294, 298-320, 333-355 and 359-378 529507017321 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.5e-32 529507017322 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 529507017323 HMMPfam hit to PF00860, Permease family, score 9.6e-81 529507017324 13 probable transmembrane helices predicted for PMI3524 by TMHMM2.0 at aa 5-27, 31-53, 55-74, 79-101, 108-130, 145-167, 174-196, 228-250, 270-292, 297-319, 324-346, 366-388 and 401-418 529507017325 PS00017 ATP/GTP-binding site motif A (P-loop). 529507017326 putative acetyltransferase YhhY; Provisional; Region: PRK10140 529507017327 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 529507017328 Coenzyme A binding pocket [chemical binding]; other site 529507017329 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.7e-20 529507017330 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 529507017331 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 529507017332 HMMPfam hit to PF00999, Sodium/hydrogen exchanger family, score 7.6e-107 529507017333 11 probable transmembrane helices predicted for PMI3526 by TMHMM2.0 at aa 4-26, 86-108, 113-135, 161-183, 188-207, 219-236, 241-260, 281-303, 313-335, 361-383 and 398-420 529507017334 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 529507017335 Signal peptide predicted for PMI3527 by SignalP 2.0 HMM (Signal peptide probability 0.739) with cleavage site probability 0.472 between residues 23 and 24 529507017336 10 probable transmembrane helices predicted for PMI3527 by TMHMM2.0 at aa 2-24, 28-47, 56-78, 83-105, 112-129, 139-158, 170-192, 202-224, 231-253 and 258-275 529507017337 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.5e-06 529507017338 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 529507017339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507017340 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 529507017341 putative dimerization interface [polypeptide binding]; other site 529507017342 HMMPfam hit to PF03466, LysR substrate binding domain, score 8.2e-46 529507017343 PS01047 Heavy-metal-associated domain. 529507017344 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.7e-14 529507017345 PS00044 Bacterial regulatory proteins, lysR family signature. 529507017346 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 529507017347 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 529507017348 THF binding site; other site 529507017349 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 529507017350 substrate binding site [chemical binding]; other site 529507017351 THF binding site; other site 529507017352 zinc-binding site [ion binding]; other site 529507017353 HMMPfam hit to PF01717, Methionine synthase, vitamin-B12 inde, score 3.1e-221 529507017354 2 probable transmembrane helices predicted for PMI3530 by TMHMM2.0 at aa 40-62 and 139-161 529507017355 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 529507017356 HMMPfam hit to PF06078, Bacterial protein of unknown function (DUF93, score 7.4e-23 529507017357 uridine phosphorylase; Provisional; Region: PRK11178 529507017358 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 529507017359 HMMPfam hit to PF01048, Phosphorylase family, score 1.1e-102 529507017360 PS01232 Purine and other phosphorylases family 1 signature. 529507017361 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 529507017362 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 529507017363 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 529507017364 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 529507017365 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 529507017366 4 probable transmembrane helices predicted for PMI3534 by TMHMM2.0 at aa 19-41, 61-83, 113-135 and 150-172 529507017367 HMMPfam hit to PF00597, DedA family, score 9.2e-20 529507017368 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 529507017369 RmuC family; Region: RmuC; pfam02646 529507017370 1 probable transmembrane helix predicted for PMI3535 by TMHMM2.0 at aa 5-27 529507017371 HMMPfam hit to PF02646, RmuC family, score 9.9e-138 529507017372 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 529507017373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507017374 S-adenosylmethionine binding site [chemical binding]; other site 529507017375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 529507017376 HMMPfam hit to PF01209, ubiE/COQ5 methyltransferase family, score 7.2e-153 529507017377 PS01183 ubiE/COQ5 methyltransferase family signature 1. 529507017378 PS01184 ubiE/COQ5 methyltransferase family signature 2. 529507017379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 529507017380 SCP-2 sterol transfer family; Region: SCP2; pfam02036 529507017381 HMMPfam hit to PF06843, Protein of unknown function (DUF1243), score 1.5e-59 529507017382 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 529507017383 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 529507017384 HMMPfam hit to PF03109, ABC1 family, score 5.6e-57 529507017385 2 probable transmembrane helices predicted for PMI3538 by TMHMM2.0 at aa 497-519 and 521-538 529507017386 twin arginine translocase protein A; Provisional; Region: tatA; PRK04598 529507017387 HMMPfam hit to PF02416, mttA/Hcf106 family, score 3.4e-09 529507017388 1 probable transmembrane helix predicted for PMI3539 by TMHMM2.0 at aa 4-21 529507017389 sec-independent translocase; Provisional; Region: PRK01770 529507017390 1 probable transmembrane helix predicted for PMI3540 by TMHMM2.0 at aa 4-21 529507017391 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 529507017392 HMMPfam hit to PF00902, Sec-independent protein translocase protein, score 9.6e-96 529507017393 6 probable transmembrane helices predicted for PMI3541 by TMHMM2.0 at aa 20-42, 74-96, 116-138, 158-180, 193-210 and 215-237 529507017394 PS01218 Uncharacterized protein family UPF0032 signature. 529507017395 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 529507017396 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 529507017397 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 529507017398 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 529507017399 Probable transposase; Region: OrfB_IS605; pfam01385 529507017400 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 529507017401 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507017402 HMMPfam hit to PF07282, transposase DNA-binding domai, score 3e-34 529507017403 HMMPfam hit to PF01385, Probable transposase, score 1.9e-132 529507017404 Transposase IS200 like; Region: Y1_Tnp; pfam01797 529507017405 HMMPfam hit to PF01797, Transposase IS200 like, score 8.2e-43 529507017406 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 529507017407 active site pocket [active] 529507017408 oxyanion hole [active] 529507017409 catalytic triad [active] 529507017410 active site nucleophile [active] 529507017411 PS00063 Aldo/keto reductase family active site signature. 529507017412 HMMPfam hit to PF03575, Peptidase family S51, score 8.5e-56 529507017413 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507017414 PS00120 Lipases, serine active site. 529507017415 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 529507017416 HMMPfam hit to PF01977, 3-octaprenyl-4-hydroxybenzoate carboxy-lyase, score 6.1e-238 529507017417 FMN reductase; Validated; Region: fre; PRK08051 529507017418 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 529507017419 FAD binding pocket [chemical binding]; other site 529507017420 FAD binding motif [chemical binding]; other site 529507017421 phosphate binding motif [ion binding]; other site 529507017422 beta-alpha-beta structure motif; other site 529507017423 NAD binding pocket [chemical binding]; other site 529507017424 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 1.5e-34 529507017425 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 529507017426 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 529507017427 dimer interface [polypeptide binding]; other site 529507017428 active site 529507017429 HMMPfam hit to PF02803, Thiolase, C-terminal domain, score 2.6e-75 529507017430 PS00099 Thiolases active site. 529507017431 PS00737 Thiolases signature 2. 529507017432 HMMPfam hit to PF00108, Thiolase, N-terminal domain, score 3.6e-113 529507017433 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 529507017434 PS00098 Thiolases acyl-enzyme intermediate signature. 529507017435 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 529507017436 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 529507017437 substrate binding site [chemical binding]; other site 529507017438 oxyanion hole (OAH) forming residues; other site 529507017439 trimer interface [polypeptide binding]; other site 529507017440 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 529507017441 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 529507017442 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 529507017443 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 8.9e-05 529507017444 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 4.5e-30 529507017445 PS00067 3-hydroxyacyl-CoA dehydrogenase signature. 529507017446 HMMPfam hit to PF02737, 3-hydroxyacyl-CoA dehydrogenase, NAD binding, score 5.8e-97 529507017447 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 3.3e-80 529507017448 PS00166 Enoyl-CoA hydratase/isomerase signature. 529507017449 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507017450 proline dipeptidase; Provisional; Region: PRK13607 529507017451 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 529507017452 active site 529507017453 HMMPfam hit to PF00557, metallopeptidase family M24, score 3e-81 529507017454 PS00491 Aminopeptidase P and proline dipeptidase signature. 529507017455 hypothetical protein; Provisional; Region: PRK11568 529507017456 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 529507017457 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 529507017458 HMMPfam hit to PF01205, Uncharacterized protein family UPF0029, score 1e-59 529507017459 PS00910 Uncharacterized protein family UPF0029 signature. 529507017460 potassium transporter; Provisional; Region: PRK10750 529507017461 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 529507017462 Signal peptide predicted for PMI3553 by SignalP 2.0 HMM (Signal peptide probability 0.903) with cleavage site probability 0.532 between residues 40 and 41 529507017463 11 probable transmembrane helices predicted for PMI3553 by TMHMM2.0 at aa 9-31, 35-57, 69-91, 133-155, 183-205, 238-260, 273-295, 332-354, 396-418, 422-444 and 456-478 529507017464 HMMPfam hit to PF02386, Cation transport protein, score 3.7e-109 529507017465 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 529507017466 Transcriptional regulators [Transcription]; Region: GntR; COG1802 529507017467 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 529507017468 DNA-binding site [nucleotide binding]; DNA binding site 529507017469 FCD domain; Region: FCD; pfam07729 529507017470 HMMPfam hit to PF07729, FCD domain, score 0.00012 529507017471 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 8.5e-20 529507017472 PS00043 Bacterial regulatory proteins, gntR family signature. 529507017473 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 529507017474 Signal peptide predicted for PMI3556 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.593 between residues 48 and 49 529507017475 11 probable transmembrane helices predicted for PMI3556 by TMHMM2.0 at aa 21-40, 50-72, 93-115, 130-144, 156-175, 190-212, 238-260, 291-313, 325-344, 348-370 and 391-413 529507017476 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 529507017477 putative active site [active] 529507017478 HMMPfam hit to PF03746, LamB/YcsF family, score 7.2e-145 529507017479 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 529507017480 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 529507017481 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 529507017482 HMMPfam hit to PF02682, Allophanate hydrolase subunit, score 8.3e-41 529507017483 HMMPfam hit to PF02626, Allophanate hydrolase subunit, score 5e-72 529507017484 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 529507017485 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 529507017486 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 529507017487 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 529507017488 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 529507017489 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 529507017490 carboxyltransferase (CT) interaction site; other site 529507017491 biotinylation site [posttranslational modification]; other site 529507017492 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 4.2e-41 529507017493 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 1.7e-98 529507017494 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 529507017495 HMMPfam hit to PF02785, Biotin carboxylase C-terminal domain, score 3.4e-57 529507017496 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 1.4e-12 529507017497 PS00188 Biotin-requiring enzymes attachment site. 529507017498 Signal peptide predicted for PMI3560 by SignalP 2.0 HMM (Signal peptide probability 0.866) with cleavage site probability 0.687 between residues 42 and 43 529507017499 HMMPfam hit to PF01925, Domain of unknown function DUF81, score 7.3e-24 529507017500 7 probable transmembrane helices predicted for PMI3560 by TMHMM2.0 at aa 7-29, 72-94, 106-128, 155-177, 189-211, 215-237 and 244-261 529507017501 His-Xaa-Ser system protein HsxD; Region: chp_LLNDYxLRE; TIGR03976 529507017502 His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978 529507017503 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 529507017504 FeS/SAM binding site; other site 529507017505 HMMPfam hit to PF04055, Radical SAM superfamily, score 3.3e-10 529507017506 His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977 529507017507 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 529507017508 FeS/SAM binding site; other site 529507017509 HMMPfam hit to PF04055, Radical SAM superfamily, score 4.3e-19 529507017510 His-Xaa-Ser repeat protein HxsA; Region: His_Ser_Rich; TIGR03979 529507017511 His-Xaa-Ser repeat protein HxsA; Region: His_Ser_Rich; TIGR03979 529507017512 Signal peptide predicted for PMI3564 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.758 between residues 22 and 23 529507017513 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 529507017514 Predicted membrane protein [Function unknown]; Region: COG4125 529507017515 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 529507017516 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 529507017517 HMMPfam hit to PF05232, Bacterial Transmembrane Pair family, score 5.6e-30 529507017518 4 probable transmembrane helices predicted for PMI3566 by TMHMM2.0 at aa 7-29, 39-58, 79-101 and 106-128 529507017519 HMMPfam hit to PF05232, Bacterial Transmembrane Pair family, score 1.1e-25 529507017520 Transcriptional regulator [Transcription]; Region: LysR; COG0583 529507017521 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507017522 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 529507017523 dimerization interface [polypeptide binding]; other site 529507017524 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 6.5e-18 529507017525 PS00044 Bacterial regulatory proteins, lysR family signature. 529507017526 HMMPfam hit to PF03466, LysR substrate binding domain, score 4e-19 529507017527 transcriptional regulator NarL; Provisional; Region: PRK10651 529507017528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507017529 active site 529507017530 phosphorylation site [posttranslational modification] 529507017531 intermolecular recognition site; other site 529507017532 dimerization interface [polypeptide binding]; other site 529507017533 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 529507017534 DNA binding residues [nucleotide binding] 529507017535 dimerization interface [polypeptide binding]; other site 529507017536 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 3.5e-24 529507017537 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.1e-39 529507017538 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 529507017539 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 529507017540 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 529507017541 dimerization interface [polypeptide binding]; other site 529507017542 Histidine kinase; Region: HisKA_3; pfam07730 529507017543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 529507017544 ATP binding site [chemical binding]; other site 529507017545 Mg2+ binding site [ion binding]; other site 529507017546 G-X-G motif; other site 529507017547 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 4.6e-17 529507017548 HMMPfam hit to PF07730, Histidine kinase, score 2.3e-18 529507017549 HMMPfam hit to PF00672, HAMP domain, score 3.4e-13 529507017550 2 probable transmembrane helices predicted for PMI3569 by TMHMM2.0 at aa 20-42 and 154-176 529507017551 Signal peptide predicted for PMI3569 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.498 between residues 49 and 50 529507017552 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 529507017553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 529507017554 putative substrate translocation pore; other site 529507017555 12 probable transmembrane helices predicted for PMI3570 by TMHMM2.0 at aa 38-60, 75-97, 104-123, 133-155, 176-198, 213-235, 256-278, 288-307, 320-339, 354-376, 404-421 and 436-458 529507017556 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 5e-17 529507017557 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 529507017558 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 529507017559 [4Fe-4S] binding site [ion binding]; other site 529507017560 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 529507017561 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 529507017562 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 529507017563 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 529507017564 molybdopterin cofactor binding site; other site 529507017565 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 529507017566 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 2.6e-146 529507017567 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507017568 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 529507017569 PS00037 Myb DNA-binding domain repeat signature 1. 529507017570 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 2.8e-39 529507017571 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 529507017572 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.01 529507017573 PS00190 Cytochrome c family heme-binding site signature. 529507017574 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.011 529507017575 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 529507017576 PS00017 ATP/GTP-binding site motif A (P-loop). 529507017577 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 529507017578 HMMPfam hit to PF02613, Nitrate reductase delta subunit, score 3.1e-67 529507017579 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 529507017580 HMMPfam hit to PF02665, Nitrate reductase gamma subunit, score 3.5e-107 529507017581 5 probable transmembrane helices predicted for PMI3574 by TMHMM2.0 at aa 4-26, 50-72, 87-109, 122-144 and 187-209 529507017582 PS00163 Fumarate lyases signature. 529507017583 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 529507017584 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 529507017585 teramer interface [polypeptide binding]; other site 529507017586 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 529507017587 active site 529507017588 FMN binding site [chemical binding]; other site 529507017589 catalytic residues [active] 529507017590 Signal peptide predicted for PMI3575 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.964 between residues 22 and 23 529507017591 HMMPfam hit to PF01070, FMN-dependent dehydrogenase, score 5.8e-128 529507017592 PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site. 529507017593 phosphoethanolamine transferase; Provisional; Region: PRK11560 529507017594 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 529507017595 Sulfatase; Region: Sulfatase; pfam00884 529507017596 HMMPfam hit to PF00884, Sulfatase, score 1.7e-71 529507017597 5 probable transmembrane helices predicted for PMI3576 by TMHMM2.0 at aa 13-35, 48-70, 83-105, 120-142 and 158-177 529507017598 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 529507017599 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 529507017600 [4Fe-4S] binding site [ion binding]; other site 529507017601 molybdopterin cofactor binding site; other site 529507017602 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 529507017603 molybdopterin cofactor binding site; other site 529507017604 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 dom, score 2.6e-18 529507017605 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 529507017606 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 4.9e-81 529507017607 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 5e-32 529507017608 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 529507017609 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507017610 Biofilm formation and stress response factor; Region: BsmA; cl01794 529507017611 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 529507017612 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 529507017613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 529507017614 Walker A motif; other site 529507017615 ATP binding site [chemical binding]; other site 529507017616 Walker B motif; other site 529507017617 arginine finger; other site 529507017618 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 2e-09 529507017619 PS00688 Sigma-54 interaction domain C-terminal part signature. 529507017620 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 1.3e-148 529507017621 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 529507017622 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 529507017623 HMMPfam hit to PF01590, GAF domain, score 2.4e-12 529507017624 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 529507017625 4Fe-4S binding domain; Region: Fer4; cl02805 529507017626 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.015 529507017627 PS00190 Cytochrome c family heme-binding site signature. 529507017628 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 1.6e-08 529507017629 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507017630 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.013 529507017631 PS00190 Cytochrome c family heme-binding site signature. 529507017632 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 529507017633 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 529507017634 HMMPfam hit to PF01155, Hydrogenase expression/synthesis hypA family, score 2.6e-63 529507017635 PS01249 Hydrogenases expression/synthesis hypA family signature. 529507017636 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 529507017637 HMMPfam hit to PF01455, HupF/HypC family, score 9.3e-45 529507017638 PS01097 Hydrogenases expression/synthesis hupF/hypC family signature. 529507017639 multidrug efflux system protein; Provisional; Region: PRK11431 529507017640 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 5.4e-48 529507017641 4 probable transmembrane helices predicted for PMI3584 by TMHMM2.0 at aa 4-26, 33-50, 55-77 and 84-103 529507017642 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 529507017643 Iron-sulfur protein interface; other site 529507017644 proximal quinone binding site [chemical binding]; other site 529507017645 C-subunit interface; other site 529507017646 distal quinone binding site; other site 529507017647 HMMPfam hit to PF02313, Fumarate reductase subunit D, score 7.8e-86 529507017648 3 probable transmembrane helices predicted for PMI3585 by TMHMM2.0 at aa 13-46, 61-83 and 96-118 529507017649 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 529507017650 D-subunit interface [polypeptide binding]; other site 529507017651 Iron-sulfur protein interface; other site 529507017652 proximal quinone binding site [chemical binding]; other site 529507017653 HMMPfam hit to PF02300, Fumarate reductase subunit C, score 8.5e-102 529507017654 3 probable transmembrane helices predicted for PMI3586 by TMHMM2.0 at aa 33-50, 65-87 and 108-130 529507017655 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 529507017656 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 529507017657 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.00077 529507017658 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507017659 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 0.0052 529507017660 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 529507017661 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 529507017662 L-aspartate oxidase; Provisional; Region: PRK06175 529507017663 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 529507017664 HMMPfam hit to PF02910, Fumarate reductase/succinate dehydroge, score 7.8e-65 529507017665 HMMPfam hit to PF00890, FAD binding domain, score 2.2e-201 529507017666 PS00037 Myb DNA-binding domain repeat signature 1. 529507017667 PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. 529507017668 Signal peptide predicted for PMI3588 by SignalP 2.0 HMM (Signal peptide probability 0.905) with cleavage site probability 0.479 between residues 25 and 26 529507017669 poxB regulator PoxA; Provisional; Region: PRK09350 529507017670 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 529507017671 motif 1; other site 529507017672 dimer interface [polypeptide binding]; other site 529507017673 active site 529507017674 motif 2; other site 529507017675 motif 3; other site 529507017676 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 8.3e-126 529507017677 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 529507017678 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 529507017679 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 529507017680 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 529507017681 active site 529507017682 catalytic site [active] 529507017683 metal binding site [ion binding]; metal-binding site 529507017684 HMMPfam hit to PF03009, Glycerophosphoryl diester phosphodiesterase, score 2.3e-98 529507017685 Signal peptide predicted for PMI3590 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.974 between residues 26 and 27 529507017686 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 529507017687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507017688 putative substrate translocation pore; other site 529507017689 12 probable transmembrane helices predicted for PMI3591 by TMHMM2.0 at aa 26-45, 65-87, 94-116, 120-142, 161-183, 188-207, 254-273, 293-312, 319-341, 351-373, 385-407 and 417-436 529507017690 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.6e-49 529507017691 PS00942 glpT family of transporters signature. 529507017692 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 529507017693 hydroxyglutarate oxidase; Provisional; Region: PRK11728 529507017694 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 529507017695 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 4.4e-67 529507017696 PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1. 529507017697 PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. 529507017698 HMMPfam hit to PF04324, BFD-like [2Fe-2S] binding domain, score 4.8e-16 529507017699 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 529507017700 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 529507017701 Signal peptide predicted for PMI3593 by SignalP 2.0 HMM (Signal peptide probability 0.938) with cleavage site probability 0.915 between residues 22 and 23 529507017702 HMMPfam hit to PF06982, Anaerobic glycerol-3-phosphate dehydrogenase, score 1.8e-186 529507017703 PS00501 Signal peptidases I serine active site. 529507017704 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 529507017705 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 529507017706 Cysteine-rich domain; Region: CCG; pfam02754 529507017707 Cysteine-rich domain; Region: CCG; pfam02754 529507017708 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507017709 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.0025 529507017710 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 529507017711 HMMPfam hit to PF02754, Cysteine-rich domain, score 2.8e-05 529507017712 HMMPfam hit to PF02754, Cysteine-rich domain, score 5.7e-14 529507017713 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 529507017714 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 529507017715 dimer interface [polypeptide binding]; other site 529507017716 active site 529507017717 metal binding site [ion binding]; metal-binding site 529507017718 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 1.9e-82 529507017719 PS00913 Iron-containing alcohol dehydrogenases signature 1. 529507017720 hypothetical protein; Provisional; Region: PRK11212 529507017721 6 probable transmembrane helices predicted for PMI3596 by TMHMM2.0 at aa 13-35, 45-64, 71-93, 108-130, 142-164 and 184-206 529507017722 HMMPfam hit to PF02592, Uncharacterized ACR, YhhQ family COG1738, score 7.1e-66 529507017723 Signal peptide predicted for PMI3596 by SignalP 2.0 HMM (Signal peptide probability 0.968) with cleavage site probability 0.667 between residues 55 and 56 529507017724 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 529507017725 CPxP motif; other site 529507017726 HMMPfam hit to PF01206, SirA-like protein, score 1.2e-37 529507017727 PS01148 Uncharacterized protein family UPF0033 signature. 529507017728 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 529507017729 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 529507017730 HlyD family secretion protein; Region: HlyD_3; pfam13437 529507017731 Signal peptide predicted for PMI3598 by SignalP 2.0 HMM (Signal peptide probability 0.970) with cleavage site probability 0.559 between residues 29 and 30 529507017732 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507017733 HMMPfam hit to PF00529, HlyD family secretion protein, score 7.3e-53 529507017734 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 529507017735 Protein export membrane protein; Region: SecD_SecF; cl14618 529507017736 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 529507017737 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 529507017738 Signal peptide predicted for PMI3599 by SignalP 2.0 HMM (Signal peptide probability 0.692) with cleavage site probability 0.216 between residues 29 and 30 529507017739 12 probable transmembrane helices predicted for PMI3599 by TMHMM2.0 at aa 9-28, 340-359, 366-388, 392-414, 438-460, 475-497, 537-554, 870-889, 896-918, 923-945, 972-994 and 1004-1026 529507017740 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 529507017741 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 529507017742 metal-binding site [ion binding] 529507017743 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 529507017744 Soluble P-type ATPase [General function prediction only]; Region: COG4087 529507017745 PS00141 Eukaryotic and viral aspartyl proteases active site. 529507017746 7 probable transmembrane helices predicted for PMI3600 by TMHMM2.0 at aa 166-183, 187-204, 216-235, 239-258, 386-408, 423-445 and 730-752 529507017747 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 7.2e-28 529507017748 PS01229 Hypothetical cof family signature 2. 529507017749 PS00154 E1-E2 ATPases phosphorylation site. 529507017750 HMMPfam hit to PF00122, E1-E2 ATPase, score 1.3e-92 529507017751 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 4e-10 529507017752 PS01047 Heavy-metal-associated domain. 529507017753 Predicted membrane protein [Function unknown]; Region: COG3714 529507017754 7 probable transmembrane helices predicted for PMI3601 by TMHMM2.0 at aa 28-45, 49-68, 75-97, 102-121, 128-147, 157-176 and 189-207 529507017755 HMMPfam hit to PF07947, YhhN-like protein, score 1e-30 529507017756 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 529507017757 Signal peptide predicted for PMI3602 by SignalP 2.0 HMM (Signal peptide probability 0.699) with cleavage site probability 0.309 between residues 22 and 23 529507017758 hypothetical protein; Provisional; Region: PRK10910 529507017759 HMMPfam hit to PF06611, Protein of unknown function (DUF1145), score 7.6e-26 529507017760 3 probable transmembrane helices predicted for PMI3603 by TMHMM2.0 at aa 4-26, 31-48 and 63-80 529507017761 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 529507017762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 529507017763 S-adenosylmethionine binding site [chemical binding]; other site 529507017764 HMMPfam hit to PF03602, Conserved hypothetical protein, score 3.1e-85 529507017765 PS00092 N-6 Adenine-specific DNA methylases signature. 529507017766 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 529507017767 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 529507017768 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 529507017769 P loop; other site 529507017770 GTP binding site [chemical binding]; other site 529507017771 HMMPfam hit to PF02881, SRP54-type protein, helical bundle domain, score 3.3e-20 529507017772 HMMPfam hit to PF00448, SRP54-type protein, GTPase domain, score 7.1e-128 529507017773 PS00017 ATP/GTP-binding site motif A (P-loop). 529507017774 PS00300 SRP54-type proteins GTP-binding domain signature. 529507017775 cell division protein FtsE; Provisional; Region: PRK10908 529507017776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507017777 Walker A/P-loop; other site 529507017778 ATP binding site [chemical binding]; other site 529507017779 Q-loop/lid; other site 529507017780 ABC transporter signature motif; other site 529507017781 Walker B; other site 529507017782 D-loop; other site 529507017783 H-loop/switch region; other site 529507017784 HMMPfam hit to PF00005, ABC transporter, score 6e-70 529507017785 PS00017 ATP/GTP-binding site motif A (P-loop). 529507017786 PS00211 ABC transporters family signature. 529507017787 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 529507017788 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 529507017789 4 probable transmembrane helices predicted for PMI3607 by TMHMM2.0 at aa 45-67, 193-215, 245-267 and 291-313 529507017790 HMMPfam hit to PF02687, Predicted permease, score 1.9e-16 529507017791 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 529507017792 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 529507017793 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 529507017794 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 529507017795 DNA binding residues [nucleotide binding] 529507017796 HMMPfam hit to PF04542, Sigma-70 region, score 7.4e-22 529507017797 PS00715 Sigma-70 factors family signature 1. 529507017798 HMMPfam hit to PF04545, Sigma-70, region, score 2e-17 529507017799 PS00716 Sigma-70 factors family signature 2. 529507017800 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 529507017801 HMMPfam hit to PF02595, Glycerate kinase family, score 1e-196 529507017802 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 529507017803 Coenzyme A binding pocket [chemical binding]; other site 529507017804 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 0.00079 529507017805 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 529507017806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507017807 putative substrate translocation pore; other site 529507017808 HMMPfam hit to PF00083, Sugar (and other) transporter, score 3.1e-05 529507017809 12 probable transmembrane helices predicted for PMI3611 by TMHMM2.0 at aa 7-29, 44-66, 73-95, 99-121, 133-155, 160-182, 212-234, 244-261, 273-295, 300-322, 335-357 and 362-384 529507017810 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 6.7e-59 529507017811 Signal peptide predicted for PMI3611 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.918 between residues 22 and 23 529507017812 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 529507017813 MarR family; Region: MarR_2; cl17246 529507017814 HMMPfam hit to PF01047, MarR family, score 2.2e-14 529507017815 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 529507017816 HMMPfam hit to PF01435, Peptidase family M48, score 3.9e-25 529507017817 PS00012 Phosphopantetheine attachment site. 529507017818 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 529507017819 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 529507017820 Walker A/P-loop; other site 529507017821 ATP binding site [chemical binding]; other site 529507017822 Q-loop/lid; other site 529507017823 ABC transporter signature motif; other site 529507017824 Walker B; other site 529507017825 D-loop; other site 529507017826 H-loop/switch region; other site 529507017827 TOBE domain; Region: TOBE_2; pfam08402 529507017828 HMMPfam hit to PF00005, ABC transporter, score 8.1e-70 529507017829 PS00211 ABC transporters family signature. 529507017830 PS00017 ATP/GTP-binding site motif A (P-loop). 529507017831 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 529507017832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507017833 dimer interface [polypeptide binding]; other site 529507017834 conserved gate region; other site 529507017835 putative PBP binding loops; other site 529507017836 ABC-ATPase subunit interface; other site 529507017837 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 9.5e-19 529507017838 6 probable transmembrane helices predicted for PMI3615 by TMHMM2.0 at aa 7-29, 83-105, 112-131, 146-168, 189-211 and 251-268 529507017839 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 529507017840 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 529507017841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 529507017842 dimer interface [polypeptide binding]; other site 529507017843 conserved gate region; other site 529507017844 putative PBP binding loops; other site 529507017845 ABC-ATPase subunit interface; other site 529507017846 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.4e-13 529507017847 6 probable transmembrane helices predicted for PMI3616 by TMHMM2.0 at aa 12-34, 72-94, 106-128, 157-179, 206-228 and 266-288 529507017848 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 529507017849 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 529507017850 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 529507017851 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 4.8e-20 529507017852 Signal peptide predicted for PMI3617 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 22 and 23 529507017853 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 529507017854 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 529507017855 putative active site [active] 529507017856 catalytic site [active] 529507017857 putative metal binding site [ion binding]; other site 529507017858 HMMPfam hit to PF03009, Glycerophosphoryl diester phosphodiesterase, score 3.8e-52 529507017859 putative cyanate transporter; Provisional; Region: cynX; PRK09705 529507017860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 529507017861 putative substrate translocation pore; other site 529507017862 12 probable transmembrane helices predicted for PMI3619 by TMHMM2.0 at aa 12-34, 49-71, 78-97, 102-124, 137-159, 164-186, 206-228, 243-265, 272-293, 297-319, 331-353 and 363-382 529507017863 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.4e-23 529507017864 10 probable transmembrane helices predicted for PMI3620 by TMHMM2.0 at aa 12-29, 39-59, 72-94, 109-128, 135-153, 157-176, 189-206, 226-248, 261-283 and 293-315 529507017865 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 529507017866 Signal peptide predicted for PMI3621 by SignalP 2.0 HMM (Signal peptide probability 0.727) with cleavage site probability 0.520 between residues 31 and 32 529507017867 1 probable transmembrane helix predicted for PMI3621 by TMHMM2.0 at aa 15-37 529507017868 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 529507017869 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 529507017870 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis family, score 4.1e-16 529507017871 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 529507017872 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 529507017873 FMN binding site [chemical binding]; other site 529507017874 active site 529507017875 catalytic residues [active] 529507017876 substrate binding site [chemical binding]; other site 529507017877 HMMPfam hit to PF01207, Dihydrouridine synthase (Dus), score 1.6e-155 529507017878 PS01136 Uncharacterized protein family UPF0034 signature. 529507017879 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 529507017880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 529507017881 HMMPfam hit to PF06325, Ribosomal protein L11 methyltransferase (Prm, score 3.1e-166 529507017882 PS00017 ATP/GTP-binding site motif A (P-loop). 529507017883 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 529507017884 Na binding site [ion binding]; other site 529507017885 13 probable transmembrane helices predicted for PMI3625 by TMHMM2.0 at aa 5-24, 37-59, 72-94, 123-145, 160-182, 187-209, 229-251, 272-294, 319-341, 369-386, 391-413, 420-442 and 446-465 529507017886 HMMPfam hit to PF00474, Sodium:solute symporter family, score 1.1e-178 529507017887 PS00456 Sodium:solute symporter family signature 1. 529507017888 hypothetical protein; Provisional; Region: PRK10633 529507017889 HMMPfam hit to PF06196, Protein of unknown function (DUF997), score 2.5e-34 529507017890 2 probable transmembrane helices predicted for PMI3626 by TMHMM2.0 at aa 13-32 and 42-64 529507017891 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 529507017892 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 529507017893 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 529507017894 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 529507017895 HMMPfam hit to PF02785, Biotin carboxylase C-terminal domain, score 2.3e-68 529507017896 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 1.1e-123 529507017897 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 529507017898 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 529507017899 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 2.4e-58 529507017900 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 529507017901 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 529507017902 carboxyltransferase (CT) interaction site; other site 529507017903 biotinylation site [posttranslational modification]; other site 529507017904 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 8.6e-39 529507017905 PS00188 Biotin-requiring enzymes attachment site. 529507017906 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 529507017907 Dehydroquinase class II; Region: DHquinase_II; pfam01220 529507017908 active site 529507017909 trimer interface [polypeptide binding]; other site 529507017910 dimer interface [polypeptide binding]; other site 529507017911 HMMPfam hit to PF01220, Dehydroquinase class II, score 3.8e-88 529507017912 PS01029 Dehydroquinase class II signature. 529507017913 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 529507017914 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 529507017915 NADP binding site [chemical binding]; other site 529507017916 dimer interface [polypeptide binding]; other site 529507017917 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 1e-32 529507017918 rod shape-determining protein MreB; Provisional; Region: PRK13927 529507017919 MreB and similar proteins; Region: MreB_like; cd10225 529507017920 nucleotide binding site [chemical binding]; other site 529507017921 Mg binding site [ion binding]; other site 529507017922 putative protofilament interaction site [polypeptide binding]; other site 529507017923 RodZ interaction site [polypeptide binding]; other site 529507017924 HMMPfam hit to PF06723, MreB/Mbl protein, score 2.2e-235 529507017925 rod shape-determining protein MreC; Region: mreC; TIGR00219 529507017926 rod shape-determining protein MreC; Region: MreC; pfam04085 529507017927 1 probable transmembrane helix predicted for PMI3632 by TMHMM2.0 at aa 13-35 529507017928 HMMPfam hit to PF04085, rod shape-determining protein MreC, score 1.2e-65 529507017929 rod shape-determining protein MreD; Provisional; Region: PRK11060 529507017930 HMMPfam hit to PF04093, rod shape-determining protein MreD, score 6.2e-38 529507017931 4 probable transmembrane helices predicted for PMI3633 by TMHMM2.0 at aa 12-29, 70-92, 99-121 and 136-153 529507017932 Maf-like protein; Region: Maf; pfam02545 529507017933 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 529507017934 active site 529507017935 dimer interface [polypeptide binding]; other site 529507017936 HMMPfam hit to PF02545, Maf-like protein, score 4.2e-73 529507017937 ribonuclease G; Provisional; Region: PRK11712 529507017938 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 529507017939 homodimer interface [polypeptide binding]; other site 529507017940 oligonucleotide binding site [chemical binding]; other site 529507017941 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 529507017942 HMMPfam hit to PF00575, S1 RNA binding domain, score 1.4e-14 529507017943 hypothetical protein; Provisional; Region: PRK10899 529507017944 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 529507017945 PS00430 TonB-dependent receptor proteins signature 1. 529507017946 Signal peptide predicted for PMI3636 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.604 between residues 20 and 21 529507017947 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 529507017948 nitrilase; Region: PLN02798 529507017949 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 529507017950 putative active site [active] 529507017951 catalytic triad [active] 529507017952 dimer interface [polypeptide binding]; other site 529507017953 HMMPfam hit to PF00795, Carbon-nitrogen hydrolase, score 1.4e-32 529507017954 PS01227 Uncharacterized protein family UPF0012 signature. 529507017955 protease TldD; Provisional; Region: tldD; PRK10735 529507017956 HMMPfam hit to PF01523, modulator of DNA gyrase, score 1.9e-105 529507017957 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 529507017958 active site 529507017959 1 probable transmembrane helix predicted for PMI3639 by TMHMM2.0 at aa 5-24 529507017960 HMMPfam hit to PF00545, ribonuclease, score 2.4e-14 529507017961 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 529507017962 RNAase interaction site [polypeptide binding]; other site 529507017963 HMMPfam hit to PF01337, Barstar (barnase inhibitor), score 1.5e-05 529507017964 hypothetical protein; Provisional; Region: PRK05255 529507017965 HMMPfam hit to PF04751, Protein of unknown function (DUF615), score 8.2e-94 529507017966 peptidase PmbA; Provisional; Region: PRK11040 529507017967 HMMPfam hit to PF01523, modulator of DNA gyrase, score 3.8e-80 529507017968 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 529507017969 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 529507017970 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 529507017971 dimerization domain swap beta strand [polypeptide binding]; other site 529507017972 regulatory protein interface [polypeptide binding]; other site 529507017973 active site 529507017974 regulatory phosphorylation site [posttranslational modification]; other site 529507017975 HMMPfam hit to PF00381, PTS HPr component phosphorylation site, score 3.5e-26 529507017976 PS00369 PTS HPR component histidine phosphorylation site signature. 529507017977 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 529507017978 HMMPfam hit to PF03668, P-loop ATPase protein family, score 2.3e-205 529507017979 PS00017 ATP/GTP-binding site motif A (P-loop). 529507017980 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 529507017981 active site 529507017982 phosphorylation site [posttranslational modification] 529507017983 HMMPfam hit to PF00359, Phosphoenolpyruvate-dependent sugar phosph, score 1.3e-42 529507017984 PS00372 PTS EIIA domains phosphorylation site signature 2. 529507017985 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 529507017986 30S subunit binding site; other site 529507017987 HMMPfam hit to PF02482, Sigma 54 modulation protein / S30EA r, score 2.6e-45 529507017988 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 529507017989 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 529507017990 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 529507017991 HMMPfam hit to PF04552, Sigma-54, DNA binding domain, score 7.8e-107 529507017992 PS00718 Sigma-54 factors family signature 2. 529507017993 PS00717 Sigma-54 factors family signature 1. 529507017994 HMMPfam hit to PF04963, Sigma-54 factor, core binding domain, score 1.7e-96 529507017995 HMMPfam hit to PF00309, Sigma-54 factor, Activator interacting do, score 6e-20 529507017996 PS00041 Bacterial regulatory proteins, araC family signature. 529507017997 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 529507017998 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 529507017999 Walker A/P-loop; other site 529507018000 ATP binding site [chemical binding]; other site 529507018001 Q-loop/lid; other site 529507018002 ABC transporter signature motif; other site 529507018003 Walker B; other site 529507018004 D-loop; other site 529507018005 H-loop/switch region; other site 529507018006 HMMPfam hit to PF00005, ABC transporter, score 2e-61 529507018007 PS00211 ABC transporters family signature. 529507018008 PS00017 ATP/GTP-binding site motif A (P-loop). 529507018009 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 529507018010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 529507018011 HMMPfam hit to PF03968, OstA-like protein, score 2.4e-54 529507018012 Signal peptide predicted for PMI3650 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.763 between residues 23 and 24 529507018013 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 529507018014 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 529507018015 HMMPfam hit to PF06835, Protein of unknown function (DUF1239), score 3.6e-54 529507018016 Signal peptide predicted for PMI3651 by SignalP 2.0 HMM (Signal peptide probability 0.969) with cleavage site probability 0.386 between residues 27 and 28 529507018017 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 529507018018 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 529507018019 active site 529507018020 motif I; other site 529507018021 motif II; other site 529507018022 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 529507018023 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 529507018024 putative active site [active] 529507018025 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 529507018026 HMMPfam hit to PF00571, CBS domain, score 2.1e-10 529507018027 HMMPfam hit to PF00571, CBS domain, score 7.8e-06 529507018028 HMMPfam hit to PF01380, SIS domain, score 6.9e-36 529507018029 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 529507018030 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 529507018031 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 529507018032 11 probable transmembrane helices predicted for PMI3654 by TMHMM2.0 at aa 5-22, 26-45, 58-80, 95-117, 130-152, 156-173, 200-222, 232-254, 267-289, 299-318 and 331-350 529507018033 HMMPfam hit to PF01699, Sodium/calcium exchanger protein, score 6.2e-34 529507018034 HMMPfam hit to PF01699, Sodium/calcium exchanger protein, score 5e-29 529507018035 Signal peptide predicted for PMI3654 by SignalP 2.0 HMM (Signal peptide probability 0.888) with cleavage site probability 0.660 between residues 44 and 45 529507018036 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 529507018037 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 529507018038 Walker A/P-loop; other site 529507018039 ATP binding site [chemical binding]; other site 529507018040 Q-loop/lid; other site 529507018041 ABC transporter signature motif; other site 529507018042 Walker B; other site 529507018043 D-loop; other site 529507018044 H-loop/switch region; other site 529507018045 HMMPfam hit to PF00005, ABC transporter, score 7.4e-51 529507018046 PS00017 ATP/GTP-binding site motif A (P-loop). 529507018047 PS00211 ABC transporters family signature. 529507018048 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 529507018049 conserved hypothetical integral membrane protein; Region: TIGR00056 529507018050 6 probable transmembrane helices predicted for PMI3656 by TMHMM2.0 at aa 10-32, 54-76, 86-108, 149-171, 198-218 and 238-257 529507018051 HMMPfam hit to PF02405, Domain of unknown function DUF140, score 9.3e-126 529507018052 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 529507018053 mce related protein; Region: MCE; pfam02470 529507018054 Signal peptide predicted for PMI3657 by SignalP 2.0 HMM (Signal peptide probability 0.644) with cleavage site probability 0.228 between residues 29 and 30 529507018055 1 probable transmembrane helix predicted for PMI3657 by TMHMM2.0 at aa 7-26 529507018056 HMMPfam hit to PF02470, mce related protein, score 1.9e-32 529507018057 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 529507018058 Signal peptide predicted for PMI3658 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 19 and 20 529507018059 HMMPfam hit to PF05494, Toluene tolerance, Ttg2, score 5.3e-82 529507018060 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 529507018061 anti sigma factor interaction site; other site 529507018062 regulatory phosphorylation site [posttranslational modification]; other site 529507018063 HMMPfam hit to PF01740, STAS domain, score 0.00037 529507018064 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 529507018065 HMMPfam hit to PF01722, BolA-like protein, score 1.6e-36 529507018066 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 529507018067 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 529507018068 hinge; other site 529507018069 active site 529507018070 HMMPfam hit to PF00275, EPSP synthase (3-phosphoshikimate 1-car, score 1.1e-178 529507018071 PS00017 ATP/GTP-binding site motif A (P-loop). 529507018072 SIR2-like domain; Region: SIR2_2; pfam13289 529507018073 10 probable transmembrane helices predicted for PMI3664 by TMHMM2.0 at aa 51-73, 83-102, 109-131, 141-160, 167-189, 199-221, 226-248, 263-282, 289-306 and 310-329 529507018074 serine endoprotease; Provisional; Region: PRK10898 529507018075 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 529507018076 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 529507018077 protein binding site [polypeptide binding]; other site 529507018078 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 2.6e-08 529507018079 HMMPfam hit to PF00089, Trypsin, score 7.5e-13 529507018080 1 probable transmembrane helix predicted for PMI3665 by TMHMM2.0 at aa 9-31 529507018081 Signal peptide predicted for PMI3665 by SignalP 2.0 HMM (Signal peptide probability 0.969) with cleavage site probability 0.765 between residues 22 and 23 529507018082 serine endoprotease; Provisional; Region: PRK10139 529507018083 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 529507018084 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 529507018085 protein binding site [polypeptide binding]; other site 529507018086 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 529507018087 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 3.8e-11 529507018088 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 1.6e-18 529507018089 HMMPfam hit to PF00089, Trypsin, score 1.8e-19 529507018090 Signal peptide predicted for PMI3666 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.968 between residues 30 and 31 529507018091 hypothetical protein; Provisional; Region: PRK11677 529507018092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 529507018093 HMMPfam hit to PF06295, Protein of unknown function (DUF1043), score 7.8e-80 529507018094 1 probable transmembrane helix predicted for PMI3667 by TMHMM2.0 at aa 4-21 529507018095 Predicted ATPase [General function prediction only]; Region: COG1485 529507018096 HMMPfam hit to PF03969, AFG1-like ATPase, score 3.1e-193 529507018097 PS00017 ATP/GTP-binding site motif A (P-loop). 529507018098 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 529507018099 23S rRNA interface [nucleotide binding]; other site 529507018100 L3 interface [polypeptide binding]; other site 529507018101 HMMPfam hit to PF00572, Ribosomal protein L13, score 1.6e-85 529507018102 PS00783 Ribosomal protein L13 signature. 529507018103 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 529507018104 HMMPfam hit to PF00380, Ribosomal protein S9/S16, score 1.6e-68 529507018105 PS00360 Ribosomal protein S9 signature. 529507018106 stringent starvation protein A; Provisional; Region: sspA; PRK09481 529507018107 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 529507018108 C-terminal domain interface [polypeptide binding]; other site 529507018109 putative GSH binding site (G-site) [chemical binding]; other site 529507018110 dimer interface [polypeptide binding]; other site 529507018111 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 529507018112 dimer interface [polypeptide binding]; other site 529507018113 N-terminal domain interface [polypeptide binding]; other site 529507018114 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 8.7e-22 529507018115 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal domain, score 1.1e-13 529507018116 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 529507018117 HMMPfam hit to PF04386, Stringent starvation protein B, score 6.3e-73 529507018118 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 529507018119 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 529507018120 DNA binding residues [nucleotide binding] 529507018121 dimer interface [polypeptide binding]; other site 529507018122 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 529507018123 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 529507018124 HMMPfam hit to PF05583, Albicidin resistance domain, score 4.4e-09 529507018125 HMMPfam hit to PF00376, MerR family regulatory protein, score 2e-11 529507018126 PS00552 Bacterial regulatory proteins, merR family signature. 529507018127 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 529507018128 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 529507018129 putative metal binding site [ion binding]; other site 529507018130 dimer interface [polypeptide binding]; other site 529507018131 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 2.5e-30 529507018132 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 0.00078 529507018133 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 529507018134 11 probable transmembrane helices predicted for PMI3675 by TMHMM2.0 at aa 5-19, 26-48, 53-72, 93-115, 130-152, 173-195, 227-249, 256-278, 293-315, 328-350 and 377-399 529507018135 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 529507018136 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 529507018137 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 529507018138 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreducta, score 1e-27 529507018139 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507018140 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 529507018141 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 529507018142 active site 529507018143 dimer interface [polypeptide binding]; other site 529507018144 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 529507018145 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 529507018146 active site 529507018147 FMN binding site [chemical binding]; other site 529507018148 substrate binding site [chemical binding]; other site 529507018149 3Fe-4S cluster binding site [ion binding]; other site 529507018150 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 529507018151 domain interface; other site 529507018152 HMMPfam hit to PF01493, GXGXG motif, score 1.7e-94 529507018153 HMMPfam hit to PF01645, Conserved region in glutamate synthas, score 5.9e-236 529507018154 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507018155 HMMPfam hit to PF04898, Glutamate synthase central domain, score 1.4e-173 529507018156 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 6.3e-206 529507018157 PS00017 ATP/GTP-binding site motif A (P-loop). 529507018158 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 529507018159 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 529507018160 putative active site [active] 529507018161 heme pocket [chemical binding]; other site 529507018162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 529507018163 dimer interface [polypeptide binding]; other site 529507018164 phosphorylation site [posttranslational modification] 529507018165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 529507018166 ATP binding site [chemical binding]; other site 529507018167 Mg2+ binding site [ion binding]; other site 529507018168 G-X-G motif; other site 529507018169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507018170 active site 529507018171 phosphorylation site [posttranslational modification] 529507018172 intermolecular recognition site; other site 529507018173 dimerization interface [polypeptide binding]; other site 529507018174 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 529507018175 putative binding surface; other site 529507018176 active site 529507018177 Signal peptide predicted for PMI3678 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.477 between residues 47 and 48 529507018178 2 probable transmembrane helices predicted for PMI3678 by TMHMM2.0 at aa 20-42 and 55-77 529507018179 HMMPfam hit to PF00989, PAS domain, score 4e-09 529507018180 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 3.2e-20 529507018181 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 4.6e-39 529507018182 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.8e-30 529507018183 HMMPfam hit to PF01627, Hpt domain, score 1.1e-13 529507018184 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 529507018185 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 529507018186 conserved cys residue [active] 529507018187 HMMPfam hit to PF01965, DJ-1/PfpI family, score 4.7e-10 529507018188 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 529507018189 Transglycosylase; Region: Transgly; cl17702 529507018190 Signal peptide predicted for PMI3680 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.655 between residues 34 and 35 529507018191 1 probable transmembrane helix predicted for PMI3680 by TMHMM2.0 at aa 13-35 529507018192 HMMPfam hit to PF00912, Transglycosylase, score 4.1e-67 529507018193 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 529507018194 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 529507018195 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 2.3e-13 529507018196 PS00041 Bacterial regulatory proteins, araC family signature. 529507018197 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 4.6e-06 529507018198 UreD urease accessory protein; Region: UreD; pfam01774 529507018199 HMMPfam hit to PF01774, UreD urease accessory protein, score 5.8e-101 529507018200 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 529507018201 alpha-gamma subunit interface [polypeptide binding]; other site 529507018202 beta-gamma subunit interface [polypeptide binding]; other site 529507018203 HMMPfam hit to PF00547, Urease, gamma subunit, score 2.9e-71 529507018204 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 529507018205 gamma-beta subunit interface [polypeptide binding]; other site 529507018206 alpha-beta subunit interface [polypeptide binding]; other site 529507018207 HMMPfam hit to PF00699, Urease beta subunit, score 1.1e-70 529507018208 urease subunit alpha; Reviewed; Region: ureC; PRK13207 529507018209 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 529507018210 subunit interactions [polypeptide binding]; other site 529507018211 active site 529507018212 flap region; other site 529507018213 HMMPfam hit to PF00449, Urease alpha-subunit, N-terminal domain, score 2.6e-92 529507018214 HMMPfam hit to PF01979, Amidohydrolase family, score 7.4e-98 529507018215 PS01120 Urease nickel ligands signature. 529507018216 PS00145 Urease active site. 529507018217 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 529507018218 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 529507018219 dimer interface [polypeptide binding]; other site 529507018220 catalytic residues [active] 529507018221 HMMPfam hit to PF02814, UreE urease accessory protein, N-terminal do, score 2.3e-26 529507018222 HMMPfam hit to PF05194, UreE urease accessory protein, C-terminal do, score 4e-40 529507018223 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 529507018224 UreF; Region: UreF; pfam01730 529507018225 HMMPfam hit to PF01730, UreF, score 2.4e-74 529507018226 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 529507018227 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 529507018228 HMMPfam hit to PF02492, CobW/HypB/UreG, nucleotide-binding domain, score 1.2e-74 529507018229 PS00017 ATP/GTP-binding site motif A (P-loop). 529507018230 outer membrane lipoprotein; Provisional; Region: PRK11023 529507018231 BON domain; Region: BON; pfam04972 529507018232 HMMPfam hit to PF04972, phospholipid-binding domain, score 1.2e-09 529507018233 HMMPfam hit to PF04972, phospholipid-binding domain, score 5.8e-09 529507018234 Signal peptide predicted for PMI3689 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.431 between residues 31 and 32 529507018235 1 probable transmembrane helix predicted for PMI3689 by TMHMM2.0 at aa 4-26 529507018236 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507018237 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 529507018238 dimer interface [polypeptide binding]; other site 529507018239 active site 529507018240 HMMPfam hit to PF01380, SIS domain, score 5.1e-21 529507018241 hypothetical protein; Reviewed; Region: PRK12497 529507018242 HMMPfam hit to PF02021, Uncharacterised protein family UPF0102, score 1.6e-36 529507018243 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 529507018244 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 529507018245 putative ligand binding site [chemical binding]; other site 529507018246 HMMPfam hit to PF04348, LppC lipoprotein, score 5.2e-47 529507018247 Signal peptide predicted for PMI3692 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.485 between residues 30 and 31 529507018248 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507018249 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 529507018250 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 529507018251 putative SAM binding site [chemical binding]; other site 529507018252 putative homodimer interface [polypeptide binding]; other site 529507018253 HMMPfam hit to PF00590, Tetrapyrrole (Corrin/Porphyrin) Methylas, score 2e-60 529507018254 PS01296 Uncharacterized protein family UPF0011 signature. 529507018255 Pirin-related protein [General function prediction only]; Region: COG1741 529507018256 Pirin; Region: Pirin; pfam02678 529507018257 HMMPfam hit to PF02678, Pirin, score 3.7e-20 529507018258 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 529507018259 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 529507018260 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 529507018261 dimerization interface [polypeptide binding]; other site 529507018262 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 7.5e-15 529507018263 PS00044 Bacterial regulatory proteins, lysR family signature. 529507018264 HMMPfam hit to PF03466, LysR substrate binding domain, score 2e-17 529507018265 Predicted membrane protein [Function unknown]; Region: COG2259 529507018266 4 probable transmembrane helices predicted for PMI3696 by TMHMM2.0 at aa 7-26, 46-68, 73-90 and 105-122 529507018267 HMMPfam hit to PF07681, DoxX, score 1.6e-35 529507018268 YqjK-like protein; Region: YqjK; pfam13997 529507018269 Predicted membrane protein [Function unknown]; Region: COG5393 529507018270 2 probable transmembrane helices predicted for PMI3698 by TMHMM2.0 at aa 50-72 and 82-104 529507018271 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 529507018272 HMMPfam hit to PF05957, Bacterial protein of unknown function (DUF88, score 5.6e-46 529507018273 1 probable transmembrane helix predicted for PMI3699 by TMHMM2.0 at aa 81-98 529507018274 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 529507018275 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 529507018276 6 probable transmembrane helices predicted for PMI3700 by TMHMM2.0 at aa 19-38, 42-61, 66-88, 126-148, 155-174 and 189-211 529507018277 HMMPfam hit to PF00597, DedA family, score 1.2e-55 529507018278 serine/threonine transporter SstT; Provisional; Region: PRK13628 529507018279 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 529507018280 8 probable transmembrane helices predicted for PMI3701 by TMHMM2.0 at aa 12-34, 49-71, 83-105, 140-162, 183-205, 215-237, 287-309 and 329-351 529507018281 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 8.7e-140 529507018282 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 529507018283 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 529507018284 active site 529507018285 FMN binding site [chemical binding]; other site 529507018286 2,4-decadienoyl-CoA binding site; other site 529507018287 catalytic residue [active] 529507018288 4Fe-4S cluster binding site [ion binding]; other site 529507018289 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 529507018290 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 529507018291 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoredu, score 1.9e-09 529507018292 HMMPfam hit to PF00724, NADH:flavin oxidoreductase / NADH oxidas, score 2.2e-124 529507018293 DoxX; Region: DoxX; pfam07681 529507018294 HMMPfam hit to PF07681, DoxX, score 2.8e-26 529507018295 3 probable transmembrane helices predicted for PMI3703 by TMHMM2.0 at aa 54-76, 81-103 and 118-135 529507018296 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 529507018297 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 529507018298 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 529507018299 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 529507018300 PS00061 Short-chain dehydrogenases/reductases family signature. 529507018301 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 2.1e-17 529507018302 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 1.5e-10 529507018303 HMMPfam hit to PF00675, Insulinase (Peptidase family M16), score 6.1e-15 529507018304 Signal peptide predicted for PMI3704 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.313 between residues 22 and 23 529507018305 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507018306 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 529507018307 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 529507018308 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 529507018309 Walker A/P-loop; other site 529507018310 ATP binding site [chemical binding]; other site 529507018311 Q-loop/lid; other site 529507018312 ABC transporter signature motif; other site 529507018313 Walker B; other site 529507018314 D-loop; other site 529507018315 H-loop/switch region; other site 529507018316 HMMPfam hit to PF00005, ABC transporter, score 1.3e-30 529507018317 PS00211 ABC transporters family signature. 529507018318 PS00017 ATP/GTP-binding site motif A (P-loop). 529507018319 5 probable transmembrane helices predicted for PMI3705 by TMHMM2.0 at aa 20-42, 62-84, 147-169, 184-206 and 268-290 529507018320 Signal peptide predicted for PMI3705 by SignalP 2.0 HMM (Signal peptide probability 0.774) with cleavage site probability 0.448 between residues 37 and 38 529507018321 Secretin and TonB N terminus short domain; Region: STN; smart00965 529507018322 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 529507018323 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 529507018324 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 529507018325 HMMPfam hit to PF00593, TonB dependent receptor, score 1.4e-12 529507018326 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 4.2e-15 529507018327 HMMPfam hit to PF07660, Secretin and TonB N terminus short domai, score 8.7e-07 529507018328 Signal peptide predicted for PMI3706 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 30 and 31 529507018329 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 529507018330 FecR protein; Region: FecR; pfam04773 529507018331 HMMPfam hit to PF04773, FecR protein, score 2.6e-26 529507018332 1 probable transmembrane helix predicted for PMI3707 by TMHMM2.0 at aa 96-118 529507018333 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 529507018334 RNA polymerase sigma factor; Reviewed; Region: PRK12527 529507018335 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 529507018336 DNA binding residues [nucleotide binding] 529507018337 HMMPfam hit to PF04545, Sigma-70, region, score 3.1e-15 529507018338 HMMPfam hit to PF04542, Sigma-70 region, score 1.2e-10 529507018339 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 529507018340 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 529507018341 Signal peptide predicted for PMI3709 by SignalP 2.0 HMM (Signal peptide probability 0.635) with cleavage site probability 0.367 between residues 33 and 34 529507018342 1 probable transmembrane helix predicted for PMI3709 by TMHMM2.0 at aa 15-37 529507018343 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 529507018344 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 529507018345 Probable transposase; Region: OrfB_IS605; pfam01385 529507018346 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 529507018347 HMMPfam hit to PF07282, transposase DNA-binding domai, score 5.8e-35 529507018348 HMMPfam hit to PF01385, Probable transposase, score 6.1e-132 529507018349 Transposase IS200 like; Region: Y1_Tnp; pfam01797 529507018350 HMMPfam hit to PF01797, Transposase IS200 like, score 1.2e-43 529507018351 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507018352 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 529507018353 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 529507018354 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 529507018355 ABC transporter; Region: ABC_tran_2; pfam12848 529507018356 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 529507018357 HMMPfam hit to PF00005, ABC transporter, score 1.7e-47 529507018358 PS00017 ATP/GTP-binding site motif A (P-loop). 529507018359 HMMPfam hit to PF00005, ABC transporter, score 5.7e-57 529507018360 PS00211 ABC transporters family signature. 529507018361 PS00017 ATP/GTP-binding site motif A (P-loop). 529507018362 lytic murein transglycosylase; Provisional; Region: PRK11619 529507018363 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 529507018364 N-acetyl-D-glucosamine binding site [chemical binding]; other site 529507018365 catalytic residue [active] 529507018366 Signal peptide predicted for PMI3713 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.916 between residues 21 and 22 529507018367 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 1.9e-32 529507018368 PS00922 Prokaryotic transglycosylases signature. 529507018369 Trp operon repressor; Provisional; Region: PRK01381 529507018370 HMMPfam hit to PF01371, Trp repressor protein, score 8.9e-37 529507018371 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 529507018372 HMMPfam hit to PF01931, Protein of unknown function DUF84, score 4.8e-54 529507018373 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 529507018374 catalytic core [active] 529507018375 HMMPfam hit to PF00300, Phosphoglycerate mutase family, score 5.6e-63 529507018376 PS00175 Phosphoglycerate mutase family phosphohistidine signature. 529507018377 1 probable transmembrane helix predicted for PMI3716 by TMHMM2.0 at aa 146-168 529507018378 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507018379 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 529507018380 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 529507018381 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 529507018382 HMMPfam hit to PF06445, Bacterial transcription activator, effect, score 3.5e-12 529507018383 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pro, score 6.1e-11 529507018384 PS00041 Bacterial regulatory proteins, araC family signature. 529507018385 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pro, score 2.6e-11 529507018386 hypothetical protein; Provisional; Region: PRK10756 529507018387 CreA protein; Region: CreA; pfam05981 529507018388 Signal peptide predicted for PMI3718 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.991 between residues 22 and 23 529507018389 HMMPfam hit to PF05981, CreA protein, score 1.1e-80 529507018390 two-component response regulator; Provisional; Region: PRK11173 529507018391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 529507018392 active site 529507018393 phosphorylation site [posttranslational modification] 529507018394 intermolecular recognition site; other site 529507018395 dimerization interface [polypeptide binding]; other site 529507018396 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 529507018397 DNA binding site [nucleotide binding] 529507018398 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 4.3e-18 529507018399 HMMPfam hit to PF00072, Response regulator receiver domain, score 8.9e-32 529507018400 Initiator Replication protein; Region: Rep_3; pfam01051 529507018401 Signal peptide predicted for PMIP01 by SignalP 2.0 HMM (Signal peptide probability 0.633) with cleavage site probability 0.483 between residues 42 and 43 529507018402 HMMPfam hit to PF01051, Initiator Replication protein, score 6.9e-28 529507018403 3 probable transmembrane helices predicted for PMIP02 by TMHMM2.0 at aa 44-66, 68-85 and 95-117 529507018404 Spo7-like protein; Region: Spo7; pfam03907 529507018405 2 probable transmembrane helices predicted for PMIP03 by TMHMM2.0 at aa 63-85 and 105-127 529507018406 Predicted helix-turn-helix motif with score 1309.000, SD 3.65 at aa 36-57, sequence SSIAELARLNNRHPDTVRKRLN 529507018407 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 529507018408 N-acetyl-D-glucosamine binding site [chemical binding]; other site 529507018409 catalytic residue [active] 529507018410 Signal peptide predicted for PMIP07 by SignalP 2.0 HMM (Signal peptide probability 0.980) with cleavage site probability 0.979 between residues 19 and 20 529507018411 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 1e-05 529507018412 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 529507018413 2 probable transmembrane helices predicted for PMIP08 by TMHMM2.0 at aa 32-54 and 59-78 529507018414 Type IV secretory pathway, VirB3-like protein; Region: VirB3; pfam05101 529507018415 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 529507018416 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 529507018417 HMMPfam hit to PF05101, Type IV secretory pathway, VirB3-like, score 3.3e-24 529507018418 1 probable transmembrane helix predicted for PMIP09 by TMHMM2.0 at aa 13-35 529507018419 HMMPfam hit to PF03135, CagE, TrbE, VirB family, component of, score 1.2e-45 529507018420 PS00017 ATP/GTP-binding site motif A (P-loop). 529507018421 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 529507018422 Type IV secretion system proteins; Region: T4SS; pfam07996 529507018423 HMMPfam hit to PF07996, Type IV secretion system proteins, score 1.9e-05 529507018424 Signal peptide predicted for PMIP10 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 23 and 24 529507018425 1 probable transmembrane helix predicted for PMIP10 by TMHMM2.0 at aa 7-29 529507018426 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507018427 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 529507018428 6 probable transmembrane helices predicted for PMIP12 by TMHMM2.0 at aa 68-90, 171-193, 200-222, 227-249, 268-290 and 305-327 529507018429 HMMPfam hit to PF04610, TrbL/VirB6 plasmid conjugal transfer protein, score 1.3e-40 529507018430 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 529507018431 VirB8 protein; Region: VirB8; pfam04335 529507018432 1 probable transmembrane helix predicted for PMIP13 by TMHMM2.0 at aa 33-55 529507018433 HMMPfam hit to PF04335, VirB8 protein, score 4.8e-47 529507018434 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 529507018435 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 529507018436 VirB7 interaction site; other site 529507018437 Signal peptide predicted for PMIP14 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.985 between residues 21 and 22 529507018438 HMMPfam hit to PF03524, Conjugal transfer protein, score 1.1e-29 529507018439 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 529507018440 1 probable transmembrane helix predicted for PMIP15 by TMHMM2.0 at aa 56-78 529507018441 HMMPfam hit to PF03743, Bacterial conjugation TrbI-like protein, score 1.9e-71 529507018442 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 529507018443 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 529507018444 ATP binding site [chemical binding]; other site 529507018445 Walker A motif; other site 529507018446 hexamer interface [polypeptide binding]; other site 529507018447 Walker B motif; other site 529507018448 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 5.9e-31 529507018449 PS00017 ATP/GTP-binding site motif A (P-loop). 529507018450 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 529507018451 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 529507018452 Walker A motif; other site 529507018453 ATP binding site [chemical binding]; other site 529507018454 Walker B motif; other site 529507018455 2 probable transmembrane helices predicted for PMIP17 by TMHMM2.0 at aa 10-32 and 63-85 529507018456 HMMPfam hit to PF02534, TraG/TraD family, score 1.3e-172 529507018457 Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117 529507018458 Signal peptide predicted for PMIP18 by SignalP 2.0 HMM (Signal peptide probability 0.858) with cleavage site probability 0.369 between residues 21 and 22 529507018459 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507018460 TrbM; Region: TrbM; pfam07424 529507018461 HMMPfam hit to PF07424, TrbM, score 1e-45 529507018462 Signal peptide predicted for PMIP19 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.987 between residues 19 and 20 529507018463 Signal peptide predicted for PMIP20 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.988 between residues 30 and 31 529507018464 1 probable transmembrane helix predicted for PMIP20 by TMHMM2.0 at aa 7-29 529507018465 2 probable transmembrane helices predicted for PMIP21 by TMHMM2.0 at aa 21-43 and 58-80 529507018466 PS00213 Lipocalin signature. 529507018467 DNA topoisomerase III; Provisional; Region: PRK07726 529507018468 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 529507018469 active site 529507018470 putative interdomain interaction site [polypeptide binding]; other site 529507018471 putative metal-binding site [ion binding]; other site 529507018472 putative nucleotide binding site [chemical binding]; other site 529507018473 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 529507018474 domain I; other site 529507018475 DNA binding groove [nucleotide binding] 529507018476 phosphate binding site [ion binding]; other site 529507018477 domain II; other site 529507018478 domain III; other site 529507018479 nucleotide binding site [chemical binding]; other site 529507018480 catalytic site [active] 529507018481 domain IV; other site 529507018482 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 529507018483 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 529507018484 HMMPfam hit to PF01751, Toprim domain, score 7e-17 529507018485 HMMPfam hit to PF01131, DNA topoisomerase, score 3.4e-87 529507018486 PS00396 Prokaryotic DNA topoisomerase I active site. 529507018487 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 529507018488 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 8.7e-05 529507018489 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 529507018490 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 0.11 529507018491 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 529507018492 HMMPfam hit to PF00816, H-NS histone family, score 8e-13 529507018493 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 529507018494 active site 529507018495 catalytic triad [active] 529507018496 oxyanion hole [active] 529507018497 Hok/gef family; Region: HOK_GEF; pfam01848 529507018498 1 probable transmembrane helix predicted for PMIP29 by TMHMM2.0 at aa 10-32 529507018499 Colicin pore forming domain; Region: Colicin; pfam01024 529507018500 PS00430 TonB-dependent receptor proteins signature 1. 529507018501 HMMPfam hit to PF01024, Colicin pore forming domain, score 4.1e-62 529507018502 PS00276 Channel forming colicins signature. 529507018503 2 probable transmembrane helices predicted for PMIP30 by TMHMM2.0 at aa 420-442 and 449-471 529507018504 Colicin immunity protein; Region: Colicin_im; pfam03857 529507018505 4 probable transmembrane helices predicted for PMIP31 by TMHMM2.0 at aa 11-33, 59-81, 97-119 and 144-166 529507018506 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 529507018507 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 529507018508 HMMPfam hit to PF05016, Plasmid stabilisation system protein, score 9.7e-16 529507018509 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 529507018510 HMMPfam hit to PF02604, Phd_YefM, score 1.8e-16 529507018511 ParA-like protein; Provisional; Region: PHA02518 529507018512 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 529507018513 P-loop; other site 529507018514 Magnesium ion binding site [ion binding]; other site 529507018515 Restriction endonuclease; Region: Mrr_cat; pfam04471 529507018516 1 probable transmembrane helix predicted for PMIP36 by TMHMM2.0 at aa 5-24 529507018517 HMMPfam hit to PF04471, Restriction endonuclease, score 7.9e-07 529507018518 HMMPfam hit to PF03432, Relaxase/Mobilisation nuclease domain, score 0.00014 529507018519 TraY domain; Region: TraY; cl17675 529507018520 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 529507018521 non-specific DNA binding site [nucleotide binding]; other site 529507018522 sequence-specific DNA binding site [nucleotide binding]; other site 529507018523 salt bridge; other site 529507018524 HMMPfam hit to PF01381, Helix-turn-helix, score 5.7e-07 529507018525 Predicted helix-turn-helix motif with score 1697.000, SD 4.97 at aa 47-68, sequence RNISQLSKETGMSREGIYKALS 529507018526 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 529507018527 HMMPfam hit to PF05973, Phage derived protein Gp49-like (DUF891), score 9.3e-23 529507018528 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 529507018529 non-specific DNA binding site [nucleotide binding]; other site 529507018530 salt bridge; other site 529507018531 sequence-specific DNA binding site [nucleotide binding]; other site 529507018532 Predicted helix-turn-helix motif with score 1509.000, SD 4.33 at aa 17-38, sequence LTQKEMAERYGVGIRTWQKKEE 529507018533 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 529507018534 HSP70 interaction site [polypeptide binding]; other site 529507018535 HMMPfam hit to PF00226, DnaJ domain, score 5.5e-13