-- dump date 20140620_003138 -- class Genbank::misc_feature -- table misc_feature_note -- id note 82654000001 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 82654000002 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654000003 putative active site [active] 82654000004 Protein of unknown function (DUF433); Region: DUF433; pfam04255 82654000005 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 82654000006 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 82654000007 P-loop; other site 82654000008 Magnesium ion binding site [ion binding]; other site 82654000009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 82654000010 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 82654000011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 82654000012 Response regulator receiver domain; Region: Response_reg; pfam00072 82654000013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654000014 active site 82654000015 phosphorylation site [posttranslational modification] 82654000016 intermolecular recognition site; other site 82654000017 dimerization interface [polypeptide binding]; other site 82654000018 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654000019 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654000020 dimer interface [polypeptide binding]; other site 82654000021 phosphorylation site [posttranslational modification] 82654000022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654000023 ATP binding site [chemical binding]; other site 82654000024 Mg2+ binding site [ion binding]; other site 82654000025 G-X-G motif; other site 82654000026 Winged helix-turn helix; Region: HTH_29; pfam13551 82654000027 Helix-turn-helix domain; Region: HTH_28; pfam13518 82654000028 Homeodomain-like domain; Region: HTH_32; pfam13565 82654000029 Response regulator receiver domain; Region: Response_reg; pfam00072 82654000030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654000031 active site 82654000032 phosphorylation site [posttranslational modification] 82654000033 intermolecular recognition site; other site 82654000034 dimerization interface [polypeptide binding]; other site 82654000035 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654000036 PAS domain; Region: PAS_9; pfam13426 82654000037 putative active site [active] 82654000038 heme pocket [chemical binding]; other site 82654000039 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654000040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654000041 dimer interface [polypeptide binding]; other site 82654000042 phosphorylation site [posttranslational modification] 82654000043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654000044 ATP binding site [chemical binding]; other site 82654000045 G-X-G motif; other site 82654000046 Response regulator receiver domain; Region: Response_reg; pfam00072 82654000047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654000048 active site 82654000049 phosphorylation site [posttranslational modification] 82654000050 intermolecular recognition site; other site 82654000051 dimerization interface [polypeptide binding]; other site 82654000052 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 82654000053 putative binding surface; other site 82654000054 active site 82654000055 PAS domain S-box; Region: sensory_box; TIGR00229 82654000056 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654000057 putative active site [active] 82654000058 heme pocket [chemical binding]; other site 82654000059 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654000060 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 82654000061 putative active site [active] 82654000062 heme pocket [chemical binding]; other site 82654000063 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654000064 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 82654000065 putative active site [active] 82654000066 heme pocket [chemical binding]; other site 82654000067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654000068 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 82654000069 putative active site [active] 82654000070 heme pocket [chemical binding]; other site 82654000071 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 82654000072 putative active site [active] 82654000073 heme pocket [chemical binding]; other site 82654000074 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654000075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654000076 dimer interface [polypeptide binding]; other site 82654000077 phosphorylation site [posttranslational modification] 82654000078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654000079 ATP binding site [chemical binding]; other site 82654000080 Mg2+ binding site [ion binding]; other site 82654000081 G-X-G motif; other site 82654000082 Response regulator receiver domain; Region: Response_reg; pfam00072 82654000083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654000084 active site 82654000085 phosphorylation site [posttranslational modification] 82654000086 intermolecular recognition site; other site 82654000087 dimerization interface [polypeptide binding]; other site 82654000088 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 82654000089 CHASE2 domain; Region: CHASE2; pfam05226 82654000090 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 82654000091 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 82654000092 metal binding site [ion binding]; metal-binding site 82654000093 active site 82654000094 I-site; other site 82654000095 photosystem I reaction center subunit X; Reviewed; Region: PRK13214 82654000096 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 82654000097 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 82654000098 active site residue [active] 82654000099 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 82654000100 active site residue [active] 82654000101 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 82654000102 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 82654000103 DNA binding residues [nucleotide binding] 82654000104 dimerization interface [polypeptide binding]; other site 82654000105 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 82654000106 Integrase core domain; Region: rve; pfam00665 82654000107 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 82654000108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654000109 Walker A motif; other site 82654000110 ATP binding site [chemical binding]; other site 82654000111 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 82654000112 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 82654000113 non-specific DNA binding site [nucleotide binding]; other site 82654000114 salt bridge; other site 82654000115 sequence-specific DNA binding site [nucleotide binding]; other site 82654000116 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 82654000117 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 82654000118 P-loop; other site 82654000119 Magnesium ion binding site [ion binding]; other site 82654000120 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 82654000121 Magnesium ion binding site [ion binding]; other site 82654000122 hypothetical protein; Reviewed; Region: PRK12275 82654000123 four helix bundle protein; Region: TIGR02436 82654000124 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 82654000125 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 82654000126 cofactor binding site; other site 82654000127 DNA binding site [nucleotide binding] 82654000128 substrate interaction site [chemical binding]; other site 82654000129 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 82654000130 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 82654000131 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 82654000132 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 82654000133 putative active site [active] 82654000134 putative NTP binding site [chemical binding]; other site 82654000135 putative nucleic acid binding site [nucleotide binding]; other site 82654000136 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 82654000137 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 82654000138 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 82654000139 active site 82654000140 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 82654000141 Calx-beta domain; Region: Calx-beta; cl02522 82654000142 RHS Repeat; Region: RHS_repeat; pfam05593 82654000143 RHS Repeat; Region: RHS_repeat; cl11982 82654000144 Family description; Region: VCBS; pfam13517 82654000145 Family description; Region: VCBS; pfam13517 82654000146 Family description; Region: VCBS; pfam13517 82654000147 Family description; Region: VCBS; pfam13517 82654000148 Family description; Region: VCBS; pfam13517 82654000149 Family description; Region: VCBS; pfam13517 82654000150 RHS Repeat; Region: RHS_repeat; pfam05593 82654000151 RHS Repeat; Region: RHS_repeat; pfam05593 82654000152 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 82654000153 RHS Repeat; Region: RHS_repeat; pfam05593 82654000154 RHS Repeat; Region: RHS_repeat; pfam05593 82654000155 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 82654000156 RHS Repeat; Region: RHS_repeat; pfam05593 82654000157 RHS Repeat; Region: RHS_repeat; pfam05593 82654000158 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 82654000159 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 82654000160 Uncharacterized conserved protein [Function unknown]; Region: COG1262 82654000161 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 82654000162 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 82654000163 active site 82654000164 DNA binding site [nucleotide binding] 82654000165 Int/Topo IB signature motif; other site 82654000166 Integrase core domain; Region: rve; pfam00665 82654000167 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 82654000168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654000169 Walker A motif; other site 82654000170 ATP binding site [chemical binding]; other site 82654000171 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 82654000172 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 82654000173 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 82654000174 ATP binding site [chemical binding]; other site 82654000175 substrate interface [chemical binding]; other site 82654000176 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 82654000177 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 82654000178 Prokaryotic E2 family E; Region: Prok-E2_E; pfam14462 82654000179 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 82654000180 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 82654000181 salt bridge; other site 82654000182 non-specific DNA binding site [nucleotide binding]; other site 82654000183 sequence-specific DNA binding site [nucleotide binding]; other site 82654000184 Protein of unknown function DUF262; Region: DUF262; pfam03235 82654000185 Uncharacterized conserved protein [Function unknown]; Region: COG1479 82654000186 Protein of unknown function DUF262; Region: DUF262; pfam03235 82654000187 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 82654000188 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654000189 putative active site [active] 82654000190 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 82654000191 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 82654000192 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 82654000193 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 82654000194 catalytic residues [active] 82654000195 catalytic nucleophile [active] 82654000196 Presynaptic Site I dimer interface [polypeptide binding]; other site 82654000197 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 82654000198 Synaptic Flat tetramer interface [polypeptide binding]; other site 82654000199 Synaptic Site I dimer interface [polypeptide binding]; other site 82654000200 DNA binding site [nucleotide binding] 82654000201 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 82654000202 DNA-binding interface [nucleotide binding]; DNA binding site 82654000203 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 82654000204 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 82654000205 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 82654000206 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 82654000207 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 82654000208 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 82654000209 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 82654000210 sequence-specific DNA binding site [nucleotide binding]; other site 82654000211 salt bridge; other site 82654000212 Integrase core domain; Region: rve; pfam00665 82654000213 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 82654000214 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654000215 Walker A motif; other site 82654000216 ATP binding site [chemical binding]; other site 82654000217 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 82654000218 Part of AAA domain; Region: AAA_19; pfam13245 82654000219 Family description; Region: UvrD_C_2; pfam13538 82654000220 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 82654000221 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 82654000222 ATP binding site [chemical binding]; other site 82654000223 putative Mg++ binding site [ion binding]; other site 82654000224 Double zinc ribbon; Region: DZR; pfam12773 82654000225 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 82654000226 ATP-binding site [chemical binding]; other site 82654000227 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 82654000228 ERCC4-like helicases [DNA replication, recombination, and repair]; Region: MPH1; COG1111 82654000229 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 82654000230 ATP binding site [chemical binding]; other site 82654000231 putative Mg++ binding site [ion binding]; other site 82654000232 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 82654000233 nucleotide binding region [chemical binding]; other site 82654000234 ATP-binding site [chemical binding]; other site 82654000235 multiple promoter invertase; Provisional; Region: mpi; PRK13413 82654000236 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 82654000237 catalytic residues [active] 82654000238 catalytic nucleophile [active] 82654000239 Presynaptic Site I dimer interface [polypeptide binding]; other site 82654000240 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 82654000241 Synaptic Flat tetramer interface [polypeptide binding]; other site 82654000242 Synaptic Site I dimer interface [polypeptide binding]; other site 82654000243 DNA binding site [nucleotide binding] 82654000244 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 82654000245 DNA-binding interface [nucleotide binding]; DNA binding site 82654000246 KWG Leptospira; Region: KWG; pfam07656 82654000247 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 82654000248 Calx-beta domain; Region: Calx-beta; cl02522 82654000249 RHS Repeat; Region: RHS_repeat; pfam05593 82654000250 RHS Repeat; Region: RHS_repeat; pfam05593 82654000251 Family description; Region: VCBS; pfam13517 82654000252 Family description; Region: VCBS; pfam13517 82654000253 Family description; Region: VCBS; pfam13517 82654000254 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 82654000255 RHS Repeat; Region: RHS_repeat; pfam05593 82654000256 RHS Repeat; Region: RHS_repeat; pfam05593 82654000257 RHS Repeat; Region: RHS_repeat; pfam05593 82654000258 RHS Repeat; Region: RHS_repeat; pfam05593 82654000259 RHS Repeat; Region: RHS_repeat; pfam05593 82654000260 RHS Repeat; Region: RHS_repeat; pfam05593 82654000261 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 82654000262 RHS Repeat; Region: RHS_repeat; cl11982 82654000263 RHS Repeat; Region: RHS_repeat; pfam05593 82654000264 RHS Repeat; Region: RHS_repeat; cl11982 82654000265 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 82654000266 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 82654000267 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 82654000268 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 82654000269 cofactor binding site; other site 82654000270 DNA binding site [nucleotide binding] 82654000271 substrate interaction site [chemical binding]; other site 82654000272 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 82654000273 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 82654000274 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654000275 putative active site [active] 82654000276 Antirestriction protein (ArdA); Region: ArdA; pfam07275 82654000277 Transposase IS200 like; Region: Y1_Tnp; pfam01797 82654000278 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 82654000279 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 82654000280 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 82654000281 ParA-like protein; Provisional; Region: PHA02518 82654000282 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 82654000283 P-loop; other site 82654000284 Magnesium ion binding site [ion binding]; other site 82654000285 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 82654000286 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 82654000287 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 82654000288 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 82654000289 non-specific DNA binding site [nucleotide binding]; other site 82654000290 salt bridge; other site 82654000291 sequence-specific DNA binding site [nucleotide binding]; other site 82654000292 MobA/MobL family; Region: MobA_MobL; pfam03389 82654000293 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 82654000294 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 82654000295 conjugal transfer protein TraL; Provisional; Region: PRK13886 82654000296 Transcriptional regulator PadR-like family; Region: PadR; cl17335 82654000297 Predicted transcriptional regulators [Transcription]; Region: COG1695 82654000298 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 82654000299 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 82654000300 Walker A motif; other site 82654000301 ATP binding site [chemical binding]; other site 82654000302 Walker B motif; other site 82654000303 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 82654000304 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 82654000305 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 82654000306 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 82654000307 non-specific DNA binding site [nucleotide binding]; other site 82654000308 salt bridge; other site 82654000309 sequence-specific DNA binding site [nucleotide binding]; other site 82654000310 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 82654000311 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 82654000312 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 82654000313 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 82654000314 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 82654000315 catalytic residues [active] 82654000316 catalytic nucleophile [active] 82654000317 Presynaptic Site I dimer interface [polypeptide binding]; other site 82654000318 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 82654000319 Synaptic Flat tetramer interface [polypeptide binding]; other site 82654000320 Synaptic Site I dimer interface [polypeptide binding]; other site 82654000321 DNA binding site [nucleotide binding] 82654000322 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 82654000323 DNA-binding interface [nucleotide binding]; DNA binding site 82654000324 Methyltransferase domain; Region: Methyltransf_12; pfam08242 82654000325 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 82654000326 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654000327 dimer interface [polypeptide binding]; other site 82654000328 phosphorylation site [posttranslational modification] 82654000329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654000330 ATP binding site [chemical binding]; other site 82654000331 Mg2+ binding site [ion binding]; other site 82654000332 G-X-G motif; other site 82654000333 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654000334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654000335 active site 82654000336 phosphorylation site [posttranslational modification] 82654000337 intermolecular recognition site; other site 82654000338 dimerization interface [polypeptide binding]; other site 82654000339 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 82654000340 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 82654000341 non-specific DNA binding site [nucleotide binding]; other site 82654000342 salt bridge; other site 82654000343 sequence-specific DNA binding site [nucleotide binding]; other site 82654000344 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 82654000345 non-specific DNA binding site [nucleotide binding]; other site 82654000346 salt bridge; other site 82654000347 sequence-specific DNA binding site [nucleotide binding]; other site 82654000348 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 82654000349 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 82654000350 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 82654000351 conjugal transfer protein TraL; Provisional; Region: PRK13886 82654000352 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 82654000353 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 82654000354 Walker A motif; other site 82654000355 ATP binding site [chemical binding]; other site 82654000356 Walker B motif; other site 82654000357 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 82654000358 metal ion-dependent adhesion site (MIDAS); other site 82654000359 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 82654000360 Predicted transcriptional regulators [Transcription]; Region: COG1695 82654000361 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 82654000362 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 82654000363 MobA/MobL family; Region: MobA_MobL; pfam03389 82654000364 Protein of unknown function, DUF399; Region: DUF399; pfam04187 82654000365 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 82654000366 iron-sulfur cluster [ion binding]; other site 82654000367 [2Fe-2S] cluster binding site [ion binding]; other site 82654000368 Predicted ATPase [General function prediction only]; Region: COG4637 82654000369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654000370 Walker A/P-loop; other site 82654000371 ATP binding site [chemical binding]; other site 82654000372 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 82654000373 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 82654000374 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654000375 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 82654000376 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654000377 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 82654000378 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 82654000379 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 82654000380 metal-binding site 82654000381 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 82654000382 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 82654000383 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 82654000384 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 82654000385 Walker A/P-loop; other site 82654000386 ATP binding site [chemical binding]; other site 82654000387 Q-loop/lid; other site 82654000388 ABC transporter signature motif; other site 82654000389 Walker B; other site 82654000390 D-loop; other site 82654000391 H-loop/switch region; other site 82654000392 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 82654000393 putative carbohydrate binding site [chemical binding]; other site 82654000394 Methyltransferase domain; Region: Methyltransf_24; pfam13578 82654000395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 82654000396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 82654000397 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 82654000398 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 82654000399 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 82654000400 PAS domain S-box; Region: sensory_box; TIGR00229 82654000401 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654000402 putative active site [active] 82654000403 heme pocket [chemical binding]; other site 82654000404 PAS fold; Region: PAS_4; pfam08448 82654000405 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 82654000406 putative active site [active] 82654000407 heme pocket [chemical binding]; other site 82654000408 PAS fold; Region: PAS_4; pfam08448 82654000409 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654000410 putative active site [active] 82654000411 heme pocket [chemical binding]; other site 82654000412 PAS domain; Region: PAS_9; pfam13426 82654000413 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654000414 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 82654000415 dimer interface [polypeptide binding]; other site 82654000416 phosphorylation site [posttranslational modification] 82654000417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654000418 ATP binding site [chemical binding]; other site 82654000419 Mg2+ binding site [ion binding]; other site 82654000420 G-X-G motif; other site 82654000421 CpeS-like protein; Region: CpeS; pfam09367 82654000422 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 82654000423 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 82654000424 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 82654000425 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 82654000426 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 82654000427 SNF2 Helicase protein; Region: DUF3670; pfam12419 82654000428 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 82654000429 ATP binding site [chemical binding]; other site 82654000430 putative Mg++ binding site [ion binding]; other site 82654000431 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 82654000432 nucleotide binding region [chemical binding]; other site 82654000433 ATP-binding site [chemical binding]; other site 82654000434 Uncharacterized conserved protein [Function unknown]; Region: COG4279 82654000435 SWIM zinc finger; Region: SWIM; pfam04434 82654000436 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 82654000437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654000438 Walker A motif; other site 82654000439 ATP binding site [chemical binding]; other site 82654000440 Integrase core domain; Region: rve; pfam00665 82654000441 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654000442 putative active site [active] 82654000443 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 82654000444 non-specific DNA binding site [nucleotide binding]; other site 82654000445 salt bridge; other site 82654000446 sequence-specific DNA binding site [nucleotide binding]; other site 82654000447 C2 domain; Region: C2; cl14603 82654000448 P-loop containing region of AAA domain; Region: AAA_29; cl17516 82654000449 AAA domain; Region: AAA_21; pfam13304 82654000450 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654000451 PAS domain; Region: PAS_9; pfam13426 82654000452 putative active site [active] 82654000453 heme pocket [chemical binding]; other site 82654000454 PAS domain S-box; Region: sensory_box; TIGR00229 82654000455 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654000456 putative active site [active] 82654000457 heme pocket [chemical binding]; other site 82654000458 PAS domain S-box; Region: sensory_box; TIGR00229 82654000459 PAS domain S-box; Region: sensory_box; TIGR00229 82654000460 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654000461 putative active site [active] 82654000462 heme pocket [chemical binding]; other site 82654000463 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 82654000464 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654000465 putative active site [active] 82654000466 heme pocket [chemical binding]; other site 82654000467 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654000468 dimer interface [polypeptide binding]; other site 82654000469 phosphorylation site [posttranslational modification] 82654000470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654000471 ATP binding site [chemical binding]; other site 82654000472 G-X-G motif; other site 82654000473 haemagglutination activity domain; Region: Haemagg_act; pfam05860 82654000474 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 82654000475 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 82654000476 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 82654000477 active site 82654000478 NTP binding site [chemical binding]; other site 82654000479 metal binding triad [ion binding]; metal-binding site 82654000480 antibiotic binding site [chemical binding]; other site 82654000481 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654000482 binding surface 82654000483 TPR motif; other site 82654000484 Tetratricopeptide repeat; Region: TPR_12; pfam13424 82654000485 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 82654000486 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 82654000487 topology modulation protein; Reviewed; Region: PRK08118 82654000488 AAA domain; Region: AAA_17; pfam13207 82654000489 Predicted permease [General function prediction only]; Region: COG3329 82654000490 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654000491 putative active site [active] 82654000492 Protein of unknown function (DUF1320); Region: DUF1320; pfam07030 82654000493 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 82654000494 CpeS-like protein; Region: CpeS; pfam09367 82654000495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 82654000496 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 82654000497 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 82654000498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 82654000499 non-specific DNA binding site [nucleotide binding]; other site 82654000500 salt bridge; other site 82654000501 sequence-specific DNA binding site [nucleotide binding]; other site 82654000502 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 82654000503 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 82654000504 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 82654000505 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654000506 putative active site [active] 82654000507 Phycobilisome protein; Region: Phycobilisome; cl08227 82654000508 HEAT repeats; Region: HEAT_2; pfam13646 82654000509 HEAT repeats; Region: HEAT_2; pfam13646 82654000510 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 82654000511 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 82654000512 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654000513 putative active site [active] 82654000514 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654000515 putative active site [active] 82654000516 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654000517 putative active site [active] 82654000518 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654000519 putative active site [active] 82654000520 Phycobilisome protein; Region: Phycobilisome; cl08227 82654000521 Phycobilisome protein; Region: Phycobilisome; cl08227 82654000522 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 82654000523 HEAT repeats; Region: HEAT_2; pfam13646 82654000524 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 82654000525 protein binding surface [polypeptide binding]; other site 82654000526 HEAT repeats; Region: HEAT_2; pfam13646 82654000527 HEAT repeats; Region: HEAT_2; pfam13646 82654000528 Phycobilisome protein; Region: Phycobilisome; cl08227 82654000529 Tic22-like family; Region: Tic22; cl04468 82654000530 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654000531 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654000532 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654000533 HEAT repeats; Region: HEAT_2; pfam13646 82654000534 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 82654000535 CpcD/allophycocyanin linker domain; Region: CpcD; smart01094 82654000536 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 82654000537 CpcD/allophycocyanin linker domain; Region: CpcD; smart01094 82654000538 CpeS-like protein; Region: CpeS; pfam09367 82654000539 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 82654000540 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 82654000541 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 82654000542 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654000543 putative active site [active] 82654000544 Putative addiction module component; Region: Unstab_antitox; pfam09720 82654000545 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 82654000546 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 82654000547 putative NAD(P) binding site [chemical binding]; other site 82654000548 active site 82654000549 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 82654000550 non-specific DNA binding site [nucleotide binding]; other site 82654000551 salt bridge; other site 82654000552 sequence-specific DNA binding site [nucleotide binding]; other site 82654000553 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654000554 putative active site [active] 82654000555 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654000556 putative active site [active] 82654000557 Methyltransferase domain; Region: Methyltransf_31; pfam13847 82654000558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654000559 S-adenosylmethionine binding site [chemical binding]; other site 82654000560 phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338 82654000561 Phycobilisome protein; Region: Phycobilisome; cl08227 82654000562 HEAT repeats; Region: HEAT_2; pfam13646 82654000563 HEAT repeats; Region: HEAT_2; pfam13646 82654000564 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 82654000565 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 82654000566 catalytic residue [active] 82654000567 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 82654000568 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 82654000569 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 82654000570 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 82654000571 Predicted membrane protein [Function unknown]; Region: COG3431 82654000572 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 82654000573 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 82654000574 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 82654000575 HEAT repeats; Region: HEAT_2; pfam13646 82654000576 HEAT repeats; Region: HEAT_2; pfam13646 82654000577 HEAT repeats; Region: HEAT_2; pfam13646 82654000578 PIN domain; Region: PIN_3; pfam13470 82654000579 Protein of unknown function (DUF416); Region: DUF416; cl01166 82654000580 DNA binding domain, excisionase family; Region: excise; TIGR01764 82654000581 L-aspartate oxidase; Provisional; Region: PRK07395 82654000582 L-aspartate oxidase; Provisional; Region: PRK06175 82654000583 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 82654000584 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654000585 putative active site [active] 82654000586 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654000587 putative active site [active] 82654000588 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 82654000589 anti sigma factor interaction site; other site 82654000590 regulatory phosphorylation site [posttranslational modification]; other site 82654000591 Protein of unknown function (DUF935); Region: DUF935; pfam06074 82654000592 CpeS-like protein; Region: CpeS; pfam09367 82654000593 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 82654000594 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 82654000595 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 82654000596 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 82654000597 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 82654000598 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 82654000599 anti sigma factor interaction site; other site 82654000600 regulatory phosphorylation site [posttranslational modification]; other site 82654000601 CpeS-like protein; Region: CpeS; pfam09367 82654000602 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 82654000603 AIR carboxylase; Region: AIRC; smart01001 82654000604 Terminase-like family; Region: Terminase_6; pfam03237 82654000605 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 82654000606 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 82654000607 CHASE2 domain; Region: CHASE2; pfam05226 82654000608 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654000609 dimer interface [polypeptide binding]; other site 82654000610 phosphorylation site [posttranslational modification] 82654000611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654000612 ATP binding site [chemical binding]; other site 82654000613 Mg2+ binding site [ion binding]; other site 82654000614 G-X-G motif; other site 82654000615 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654000616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654000617 active site 82654000618 phosphorylation site [posttranslational modification] 82654000619 intermolecular recognition site; other site 82654000620 dimerization interface [polypeptide binding]; other site 82654000621 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 82654000622 sulfotransferase; Region: PLN02164 82654000623 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654000624 putative active site [active] 82654000625 DnaA N-terminal domain; Region: DnaA_N; pfam11638 82654000626 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 82654000627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654000628 Walker A motif; other site 82654000629 ATP binding site [chemical binding]; other site 82654000630 Walker B motif; other site 82654000631 arginine finger; other site 82654000632 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 82654000633 DnaA box-binding interface [nucleotide binding]; other site 82654000634 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 82654000635 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 82654000636 active site 82654000637 HIGH motif; other site 82654000638 dimer interface [polypeptide binding]; other site 82654000639 KMSKS motif; other site 82654000640 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 82654000641 G1 box; other site 82654000642 GTP/Mg2+ binding site [chemical binding]; other site 82654000643 FOG: WD40 repeat [General function prediction only]; Region: COG2319 82654000644 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 82654000645 structural tetrad; other site 82654000646 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 82654000647 structural tetrad; other site 82654000648 FOG: WD40 repeat [General function prediction only]; Region: COG2319 82654000649 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 82654000650 structural tetrad; other site 82654000651 Calcium binding; Region: Calci_bind_CcbP; pfam11535 82654000652 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 82654000653 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 82654000654 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 82654000655 Peptidase family M23; Region: Peptidase_M23; pfam01551 82654000656 putative high light inducible protein; Region: PHA02337 82654000657 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 82654000658 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 82654000659 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 82654000660 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 82654000661 TPR repeat; Region: TPR_11; pfam13414 82654000662 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 82654000663 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 82654000664 putative ligand binding site [chemical binding]; other site 82654000665 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 82654000666 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 82654000667 putative ligand binding site [chemical binding]; other site 82654000668 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 82654000669 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 82654000670 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 82654000671 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654000672 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654000673 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654000674 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654000675 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654000676 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 82654000677 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654000678 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654000679 hypothetical protein; Validated; Region: PRK07413 82654000680 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 82654000681 Walker A motif; other site 82654000682 homodimer interface [polypeptide binding]; other site 82654000683 ATP binding site [chemical binding]; other site 82654000684 hydroxycobalamin binding site [chemical binding]; other site 82654000685 Walker B motif; other site 82654000686 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 82654000687 Walker A motif; other site 82654000688 homodimer interface [polypeptide binding]; other site 82654000689 ATP binding site [chemical binding]; other site 82654000690 hydroxycobalamin binding site [chemical binding]; other site 82654000691 Walker B motif; other site 82654000692 TIR domain; Region: TIR_2; pfam13676 82654000693 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 82654000694 active site 82654000695 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 82654000696 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 82654000697 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 82654000698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 82654000699 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 82654000700 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 82654000701 Phosphotransferase enzyme family; Region: APH; pfam01636 82654000702 Methyltransferase domain; Region: Methyltransf_23; pfam13489 82654000703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654000704 S-adenosylmethionine binding site [chemical binding]; other site 82654000705 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 82654000706 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 82654000707 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 82654000708 Family description; Region: UvrD_C_2; pfam13538 82654000709 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654000710 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654000711 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654000712 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 82654000713 dimerization interface [polypeptide binding]; other site 82654000714 putative DNA binding site [nucleotide binding]; other site 82654000715 putative Zn2+ binding site [ion binding]; other site 82654000716 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 82654000717 Secretin and TonB N terminus short domain; Region: STN; pfam07660 82654000718 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 82654000719 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 82654000720 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 82654000721 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 82654000722 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 82654000723 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 82654000724 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 82654000725 glycine dehydrogenase; Provisional; Region: PRK05367 82654000726 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 82654000727 tetramer interface [polypeptide binding]; other site 82654000728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 82654000729 catalytic residue [active] 82654000730 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 82654000731 tetramer interface [polypeptide binding]; other site 82654000732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 82654000733 catalytic residue [active] 82654000734 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 82654000735 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 82654000736 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 82654000737 active site 82654000738 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 82654000739 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 82654000740 putative dimer interface [polypeptide binding]; other site 82654000741 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 82654000742 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 82654000743 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 82654000744 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 82654000745 inhibitor-cofactor binding pocket; inhibition site 82654000746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 82654000747 catalytic residue [active] 82654000748 Cytotoxic; Region: Cytotoxic; pfam09000 82654000749 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 82654000750 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 82654000751 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 82654000752 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 82654000753 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 82654000754 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 82654000755 ATP synthase subunit D; Region: ATP-synt_D; cl00613 82654000756 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 82654000757 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 82654000758 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 82654000759 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 82654000760 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 82654000761 active site 82654000762 substrate binding site [chemical binding]; other site 82654000763 cosubstrate binding site; other site 82654000764 catalytic site [active] 82654000765 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 82654000766 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 82654000767 Walker A/P-loop; other site 82654000768 ATP binding site [chemical binding]; other site 82654000769 Q-loop/lid; other site 82654000770 ABC transporter signature motif; other site 82654000771 Walker B; other site 82654000772 D-loop; other site 82654000773 H-loop/switch region; other site 82654000774 TOBE domain; Region: TOBE_2; pfam08402 82654000775 glycogen branching enzyme; Provisional; Region: PRK05402 82654000776 Carbohydrate-binding module 48 (Isoamylase N-terminal domain); Region: CBM_48; pfam02922 82654000777 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 82654000778 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 82654000779 active site 82654000780 catalytic site [active] 82654000781 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 82654000782 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 82654000783 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654000784 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654000785 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654000786 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654000787 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654000788 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654000789 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654000790 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654000791 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654000792 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654000793 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 82654000794 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 82654000795 RNA binding site [nucleotide binding]; other site 82654000796 active site 82654000797 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 82654000798 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 82654000799 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 82654000800 ArsC family; Region: ArsC; pfam03960 82654000801 catalytic residues [active] 82654000802 Predicted membrane protein [Function unknown]; Region: COG1950 82654000803 KpsF/GutQ family protein; Region: kpsF; TIGR00393 82654000804 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 82654000805 putative active site [active] 82654000806 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 82654000807 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 82654000808 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 82654000809 Ligand binding site; other site 82654000810 oligomer interface; other site 82654000811 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 82654000812 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 82654000813 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 82654000814 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 82654000815 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 82654000816 inhibitor-cofactor binding pocket; inhibition site 82654000817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 82654000818 catalytic residue [active] 82654000819 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 82654000820 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 82654000821 NAD(P) binding site [chemical binding]; other site 82654000822 homodimer interface [polypeptide binding]; other site 82654000823 substrate binding site [chemical binding]; other site 82654000824 active site 82654000825 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654000826 GAF domain; Region: GAF; pfam01590 82654000827 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 82654000828 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 82654000829 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 82654000830 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 82654000831 2-isopropylmalate synthase; Validated; Region: PRK00915 82654000832 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 82654000833 active site 82654000834 catalytic residues [active] 82654000835 metal binding site [ion binding]; metal-binding site 82654000836 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 82654000837 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 82654000838 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 82654000839 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 82654000840 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 82654000841 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 82654000842 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 82654000843 Walker A/P-loop; other site 82654000844 ATP binding site [chemical binding]; other site 82654000845 Q-loop/lid; other site 82654000846 ABC transporter signature motif; other site 82654000847 Walker B; other site 82654000848 D-loop; other site 82654000849 H-loop/switch region; other site 82654000850 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 82654000851 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 82654000852 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 82654000853 active site 82654000854 catalytic site [active] 82654000855 Predicted transcriptional regulators [Transcription]; Region: COG1725 82654000856 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 82654000857 DNA-binding site [nucleotide binding]; DNA binding site 82654000858 cytosine deaminase-like protein; Validated; Region: PRK07583 82654000859 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 82654000860 active site 82654000861 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 82654000862 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 82654000863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 82654000864 homodimer interface [polypeptide binding]; other site 82654000865 catalytic residue [active] 82654000866 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 82654000867 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 82654000868 dimerization interface [polypeptide binding]; other site 82654000869 DPS ferroxidase diiron center [ion binding]; other site 82654000870 ion pore; other site 82654000871 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 82654000872 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 82654000873 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 82654000874 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 82654000875 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 82654000876 CAAX protease self-immunity; Region: Abi; pfam02517 82654000877 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 82654000878 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 82654000879 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 82654000880 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 82654000881 putative catalytic residue [active] 82654000882 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 82654000883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654000884 Tetratricopeptide repeat; Region: TPR_16; pfam13432 82654000885 binding surface 82654000886 TPR motif; other site 82654000887 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654000888 binding surface 82654000889 TPR motif; other site 82654000890 Tetratricopeptide repeat; Region: TPR_16; pfam13432 82654000891 Tetratricopeptide repeat; Region: TPR_12; pfam13424 82654000892 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654000893 binding surface 82654000894 TPR repeat; Region: TPR_11; pfam13414 82654000895 TPR motif; other site 82654000896 TPR repeat; Region: TPR_11; pfam13414 82654000897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654000898 Tetratricopeptide repeat; Region: TPR_12; pfam13424 82654000899 binding surface 82654000900 TPR motif; other site 82654000901 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 82654000902 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 82654000903 ligand binding site [chemical binding]; other site 82654000904 flexible hinge region; other site 82654000905 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 82654000906 active site 82654000907 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 82654000908 substrate binding site; other site 82654000909 dimer interface; other site 82654000910 Protein of unknown function (DUF497); Region: DUF497; pfam04365 82654000911 GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450 82654000912 GIY-YIG motif/motif A; other site 82654000913 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 82654000914 Protein of unknown function (DUF2396); Region: DUF2396; pfam09654 82654000915 phosphoribulokinase; Provisional; Region: PRK07429 82654000916 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 82654000917 active site 82654000918 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 82654000919 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654000920 active site 82654000921 ATP binding site [chemical binding]; other site 82654000922 substrate binding site [chemical binding]; other site 82654000923 activation loop (A-loop); other site 82654000924 CAAX protease self-immunity; Region: Abi; pfam02517 82654000925 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 82654000926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 82654000927 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 82654000928 4Fe-4S binding domain; Region: Fer4_5; pfam12801 82654000929 4Fe-4S binding domain; Region: Fer4_5; pfam12801 82654000930 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 82654000931 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 82654000932 Haemolytic domain; Region: Haemolytic; pfam01809 82654000933 O-Antigen ligase; Region: Wzy_C; pfam04932 82654000934 Calx-beta domain; Region: Calx-beta; cl02522 82654000935 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 82654000936 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 82654000937 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 82654000938 DNA binding residues [nucleotide binding] 82654000939 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 82654000940 ABC1 family; Region: ABC1; cl17513 82654000941 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 82654000942 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 82654000943 catalytic motif [active] 82654000944 Zn binding site [ion binding]; other site 82654000945 RibD C-terminal domain; Region: RibD_C; cl17279 82654000946 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 82654000947 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 82654000948 phosphopeptide binding site; other site 82654000949 PAS domain S-box; Region: sensory_box; TIGR00229 82654000950 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 82654000951 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 82654000952 metal binding site [ion binding]; metal-binding site 82654000953 active site 82654000954 I-site; other site 82654000955 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 82654000956 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 82654000957 PAS domain; Region: PAS; smart00091 82654000958 putative active site [active] 82654000959 heme pocket [chemical binding]; other site 82654000960 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654000961 dimer interface [polypeptide binding]; other site 82654000962 phosphorylation site [posttranslational modification] 82654000963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654000964 ATP binding site [chemical binding]; other site 82654000965 Mg2+ binding site [ion binding]; other site 82654000966 G-X-G motif; other site 82654000967 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 82654000968 regulatory phosphorylation site [posttranslational modification]; other site 82654000969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 82654000970 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 82654000971 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 82654000972 ATP binding site [chemical binding]; other site 82654000973 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 82654000974 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 82654000975 FOG: WD40 repeat [General function prediction only]; Region: COG2319 82654000976 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 82654000977 structural tetrad; other site 82654000978 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 82654000979 haemagglutination activity domain; Region: Haemagg_act; pfam05860 82654000980 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 82654000981 CHAT domain; Region: CHAT; cl17868 82654000982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654000983 S-adenosylmethionine binding site [chemical binding]; other site 82654000984 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 82654000985 mercuric reductase; Validated; Region: PRK06370 82654000986 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 82654000987 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 82654000988 Uncharacterized conserved protein [Function unknown]; Region: COG0398 82654000989 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 82654000990 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945 82654000991 L-aspartate oxidase; Provisional; Region: PRK06175 82654000992 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 82654000993 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; cl09741 82654000994 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 82654000995 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 82654000996 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 82654000997 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 82654000998 putative active site [active] 82654000999 Ap4A binding site [chemical binding]; other site 82654001000 nudix motif; other site 82654001001 putative metal binding site [ion binding]; other site 82654001002 acetolactate synthase; Reviewed; Region: PRK08322 82654001003 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 82654001004 PYR/PP interface [polypeptide binding]; other site 82654001005 dimer interface [polypeptide binding]; other site 82654001006 TPP binding site [chemical binding]; other site 82654001007 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 82654001008 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 82654001009 TPP-binding site [chemical binding]; other site 82654001010 dimer interface [polypeptide binding]; other site 82654001011 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 82654001012 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 82654001013 NAD(P) binding site [chemical binding]; other site 82654001014 catalytic residues [active] 82654001015 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001016 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654001017 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001018 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654001019 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001020 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 82654001021 histidinol dehydrogenase; Region: hisD; TIGR00069 82654001022 NAD binding site [chemical binding]; other site 82654001023 dimerization interface [polypeptide binding]; other site 82654001024 product binding site; other site 82654001025 substrate binding site [chemical binding]; other site 82654001026 zinc binding site [ion binding]; other site 82654001027 catalytic residues [active] 82654001028 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 82654001029 active site 82654001030 oxyanion hole [active] 82654001031 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 82654001032 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 82654001033 ligand binding site [chemical binding]; other site 82654001034 flexible hinge region; other site 82654001035 HEAT repeats; Region: HEAT_2; pfam13646 82654001036 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 82654001037 Predicted transcriptional regulators [Transcription]; Region: COG1695 82654001038 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 82654001039 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 82654001040 Putative ammonia monooxygenase; Region: AmoA; pfam05145 82654001041 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 82654001042 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 82654001043 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 82654001044 catalytic triad [active] 82654001045 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 82654001046 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 82654001047 acyl-activating enzyme (AAE) consensus motif; other site 82654001048 putative AMP binding site [chemical binding]; other site 82654001049 putative active site [active] 82654001050 putative CoA binding site [chemical binding]; other site 82654001051 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 82654001052 phosphodiesterase YaeI; Provisional; Region: PRK11340 82654001053 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 82654001054 active site 82654001055 metal binding site [ion binding]; metal-binding site 82654001056 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 82654001057 G1 box; other site 82654001058 GTP/Mg2+ binding site [chemical binding]; other site 82654001059 G2 box; other site 82654001060 Switch I region; other site 82654001061 G3 box; other site 82654001062 Switch II region; other site 82654001063 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 82654001064 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 82654001065 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654001066 active site 82654001067 ATP binding site [chemical binding]; other site 82654001068 substrate binding site [chemical binding]; other site 82654001069 activation loop (A-loop); other site 82654001070 AAA ATPase domain; Region: AAA_16; pfam13191 82654001071 Predicted ATPase [General function prediction only]; Region: COG3899 82654001072 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654001073 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654001074 PAS domain S-box; Region: sensory_box; TIGR00229 82654001075 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654001076 putative active site [active] 82654001077 heme pocket [chemical binding]; other site 82654001078 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 82654001079 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 82654001080 Right handed beta helix region; Region: Beta_helix; pfam13229 82654001081 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 82654001082 Mechanosensitive ion channel; Region: MS_channel; pfam00924 82654001083 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 82654001084 homotrimer interaction site [polypeptide binding]; other site 82654001085 putative active site [active] 82654001086 TM2 domain; Region: TM2; pfam05154 82654001087 Short C-terminal domain; Region: SHOCT; pfam09851 82654001088 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 82654001089 Double zinc ribbon; Region: DZR; pfam12773 82654001090 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 82654001091 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654001092 active site 82654001093 ATP binding site [chemical binding]; other site 82654001094 substrate binding site [chemical binding]; other site 82654001095 activation loop (A-loop); other site 82654001096 TM2 domain; Region: TM2; pfam05154 82654001097 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 82654001098 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 82654001099 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 82654001100 UbiA prenyltransferase family; Region: UbiA; pfam01040 82654001101 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 82654001102 UreF; Region: UreF; pfam01730 82654001103 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 82654001104 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 82654001105 dimer interface [polypeptide binding]; other site 82654001106 catalytic residues [active] 82654001107 Calx-beta domain; Region: Calx-beta; cl02522 82654001108 Calx-beta domain; Region: Calx-beta; cl02522 82654001109 Calx-beta domain; Region: Calx-beta; cl02522 82654001110 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 82654001111 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 82654001112 Calx-beta domain; Region: Calx-beta; cl02522 82654001113 CemA family; Region: CemA; cl03855 82654001114 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 82654001115 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 82654001116 ABC-2 type transporter; Region: ABC2_membrane; cl17235 82654001117 PsbP; Region: PsbP; pfam01789 82654001118 Response regulator receiver domain; Region: Response_reg; pfam00072 82654001119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654001120 active site 82654001121 phosphorylation site [posttranslational modification] 82654001122 intermolecular recognition site; other site 82654001123 dimerization interface [polypeptide binding]; other site 82654001124 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 82654001125 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 82654001126 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 82654001127 anti sigma factor interaction site; other site 82654001128 regulatory phosphorylation site [posttranslational modification]; other site 82654001129 Domain of unknown function DUF59; Region: DUF59; pfam01883 82654001130 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 82654001131 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 82654001132 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 82654001133 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 82654001134 Subunit I/III interface [polypeptide binding]; other site 82654001135 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 82654001136 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 82654001137 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 82654001138 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 82654001139 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 82654001140 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 82654001141 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 82654001142 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 82654001143 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001144 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654001145 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001146 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001147 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001148 TPR repeat; Region: TPR_11; pfam13414 82654001149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654001150 TPR motif; other site 82654001151 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 82654001152 argininosuccinate lyase; Provisional; Region: PRK00855 82654001153 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 82654001154 active sites [active] 82654001155 tetramer interface [polypeptide binding]; other site 82654001156 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 82654001157 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 82654001158 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 82654001159 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 82654001160 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 82654001161 Mechanosensitive ion channel; Region: MS_channel; pfam00924 82654001162 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 82654001163 active site 82654001164 ATP binding site [chemical binding]; other site 82654001165 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654001166 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001167 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001168 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001169 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 82654001170 metal ion-dependent adhesion site (MIDAS); other site 82654001171 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 82654001172 S-layer homology domain; Region: SLH; pfam00395 82654001173 chorismate binding enzyme; Region: Chorismate_bind; cl10555 82654001174 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 82654001175 Domain of unknown function DUF11; Region: DUF11; pfam01345 82654001176 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 82654001177 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 82654001178 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 82654001179 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 82654001180 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 82654001181 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 82654001182 catalytic triad [active] 82654001183 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 82654001184 Photosystem II protein; Region: PSII; cl08223 82654001185 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 82654001186 photosystem II protein D2; Region: psbD; CHL00004 82654001187 pheophytin binding site; other site 82654001188 chlorophyll binding site; other site 82654001189 quinone binding site; other site 82654001190 Fe binding site [ion binding]; other site 82654001191 Uncharacterized conserved protein [Function unknown]; Region: COG0398 82654001192 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 82654001193 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 82654001194 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 82654001195 FeS/SAM binding site; other site 82654001196 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 82654001197 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 82654001198 Coenzyme A binding pocket [chemical binding]; other site 82654001199 DinB superfamily; Region: DinB_2; pfam12867 82654001200 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 82654001201 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 82654001202 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 82654001203 putative active site [active] 82654001204 putative dimer interface [polypeptide binding]; other site 82654001205 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 82654001206 active site 82654001207 catalytic triad [active] 82654001208 oxyanion hole [active] 82654001209 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 82654001210 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 82654001211 active site 82654001212 catalytic site [active] 82654001213 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 82654001214 starch-binding site 2 [chemical binding]; other site 82654001215 starch-binding site 1 [chemical binding]; other site 82654001216 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654001217 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001218 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001219 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001220 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001221 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001222 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001223 Gas vesicle protein G; Region: GvpG; pfam05120 82654001224 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 82654001225 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 82654001226 quinone interaction residues [chemical binding]; other site 82654001227 active site 82654001228 catalytic residues [active] 82654001229 FMN binding site [chemical binding]; other site 82654001230 substrate binding site [chemical binding]; other site 82654001231 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 82654001232 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 82654001233 Walker A/P-loop; other site 82654001234 ATP binding site [chemical binding]; other site 82654001235 Q-loop/lid; other site 82654001236 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 82654001237 ABC transporter signature motif; other site 82654001238 Walker B; other site 82654001239 D-loop; other site 82654001240 H-loop/switch region; other site 82654001241 KTSC domain; Region: KTSC; pfam13619 82654001242 FecR protein; Region: FecR; pfam04773 82654001243 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 82654001244 active site residue [active] 82654001245 GUN4-like; Region: GUN4; pfam05419 82654001246 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 82654001247 transketolase; Region: PLN02790 82654001248 TPP-binding site [chemical binding]; other site 82654001249 dimer interface [polypeptide binding]; other site 82654001250 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 82654001251 PYR/PP interface [polypeptide binding]; other site 82654001252 dimer interface [polypeptide binding]; other site 82654001253 TPP binding site [chemical binding]; other site 82654001254 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 82654001255 Protein of unknown function (DUF751); Region: DUF751; pfam05421 82654001256 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 82654001257 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 82654001258 CHASE2 domain; Region: CHASE2; pfam05226 82654001259 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 82654001260 cyclase homology domain; Region: CHD; cd07302 82654001261 nucleotidyl binding site; other site 82654001262 metal binding site [ion binding]; metal-binding site 82654001263 dimer interface [polypeptide binding]; other site 82654001264 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654001265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654001266 active site 82654001267 phosphorylation site [posttranslational modification] 82654001268 intermolecular recognition site; other site 82654001269 dimerization interface [polypeptide binding]; other site 82654001270 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 82654001271 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 82654001272 substrate binding pocket [chemical binding]; other site 82654001273 membrane-bound complex binding site; other site 82654001274 hinge residues; other site 82654001275 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 82654001276 TPR repeat; Region: TPR_11; pfam13414 82654001277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654001278 binding surface 82654001279 TPR motif; other site 82654001280 Tetratricopeptide repeat; Region: TPR_16; pfam13432 82654001281 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001282 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654001283 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001284 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001285 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 82654001286 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 82654001287 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 82654001288 malate dehydrogenase; Reviewed; Region: PRK06223 82654001289 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 82654001290 NAD(P) binding site [chemical binding]; other site 82654001291 dimer interface [polypeptide binding]; other site 82654001292 tetramer (dimer of dimers) interface [polypeptide binding]; other site 82654001293 substrate binding site [chemical binding]; other site 82654001294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654001295 TPR motif; other site 82654001296 binding surface 82654001297 TPR repeat; Region: TPR_11; pfam13414 82654001298 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654001299 binding surface 82654001300 TPR motif; other site 82654001301 Tetratricopeptide repeat; Region: TPR_12; pfam13424 82654001302 Uncharacterized conserved protein [Function unknown]; Region: COG3937 82654001303 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 82654001304 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654001305 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001306 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001307 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654001308 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001309 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001310 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 82654001311 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 82654001312 P loop; other site 82654001313 Nucleotide binding site [chemical binding]; other site 82654001314 DTAP/Switch II; other site 82654001315 Switch I; other site 82654001316 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 82654001317 DTAP/Switch II; other site 82654001318 Switch I; other site 82654001319 Protein of unknown function DUF45; Region: DUF45; pfam01863 82654001320 Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; pfam10107 82654001321 sulfate transport protein; Provisional; Region: cysT; CHL00187 82654001322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654001323 dimer interface [polypeptide binding]; other site 82654001324 conserved gate region; other site 82654001325 putative PBP binding loops; other site 82654001326 ABC-ATPase subunit interface; other site 82654001327 sulfate transport protein; Provisional; Region: cysT; CHL00187 82654001328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654001329 dimer interface [polypeptide binding]; other site 82654001330 conserved gate region; other site 82654001331 putative PBP binding loops; other site 82654001332 ABC-ATPase subunit interface; other site 82654001333 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 82654001334 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 82654001335 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 82654001336 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654001337 putative active site [active] 82654001338 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952 82654001339 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 82654001340 dimer interface [polypeptide binding]; other site 82654001341 active site 82654001342 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 82654001343 active site 82654001344 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 82654001345 Clp amino terminal domain; Region: Clp_N; pfam02861 82654001346 Clp amino terminal domain; Region: Clp_N; pfam02861 82654001347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654001348 Walker A motif; other site 82654001349 ATP binding site [chemical binding]; other site 82654001350 Walker B motif; other site 82654001351 arginine finger; other site 82654001352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654001353 Walker A motif; other site 82654001354 ATP binding site [chemical binding]; other site 82654001355 Walker B motif; other site 82654001356 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 82654001357 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 82654001358 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 82654001359 TM-ABC transporter signature motif; other site 82654001360 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 82654001361 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654001362 active site 82654001363 ATP binding site [chemical binding]; other site 82654001364 substrate binding site [chemical binding]; other site 82654001365 activation loop (A-loop); other site 82654001366 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 82654001367 methionine sulfoxide reductase A; Provisional; Region: PRK00058 82654001368 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 82654001369 intracellular protease, PfpI family; Region: PfpI; TIGR01382 82654001370 conserved cys residue [active] 82654001371 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 82654001372 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 82654001373 EthD domain; Region: EthD; pfam07110 82654001374 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 82654001375 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 82654001376 active site 82654001377 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 82654001378 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 82654001379 active site 82654001380 catalytic site [active] 82654001381 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 82654001382 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 82654001383 putative active site [active] 82654001384 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 82654001385 active site 82654001386 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 82654001387 ATP-grasp domain; Region: ATP-grasp; pfam02222 82654001388 AIR carboxylase; Region: AIRC; pfam00731 82654001389 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654001390 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001391 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001392 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001393 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001394 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001395 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 82654001396 cyclase homology domain; Region: CHD; cd07302 82654001397 nucleotidyl binding site; other site 82654001398 metal binding site [ion binding]; metal-binding site 82654001399 dimer interface [polypeptide binding]; other site 82654001400 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 82654001401 Protein export membrane protein; Region: SecD_SecF; pfam02355 82654001402 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 82654001403 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 82654001404 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 82654001405 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 82654001406 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 82654001407 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 82654001408 precorrin-8X methylmutase; Validated; Region: PRK05953 82654001409 Precorrin-8X methylmutase; Region: CbiC; pfam02570 82654001410 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 82654001411 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cd04722 82654001412 phosphate binding site [ion binding]; other site 82654001413 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 82654001414 substrate binding site [chemical binding]; other site 82654001415 putative active site [active] 82654001416 redox center [active] 82654001417 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 82654001418 thiamine monophosphate kinase; Provisional; Region: PRK05731 82654001419 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 82654001420 ATP binding site [chemical binding]; other site 82654001421 dimerization interface [polypeptide binding]; other site 82654001422 Clp protease; Region: CLP_protease; pfam00574 82654001423 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 82654001424 oligomer interface [polypeptide binding]; other site 82654001425 active site residues [active] 82654001426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 82654001427 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 82654001428 Peptidase family M23; Region: Peptidase_M23; pfam01551 82654001429 magnesium chelatase subunit H; Provisional; Region: PRK12493 82654001430 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 82654001431 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 82654001432 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 82654001433 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 82654001434 dimer interface [polypeptide binding]; other site 82654001435 motif 1; other site 82654001436 active site 82654001437 motif 2; other site 82654001438 motif 3; other site 82654001439 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 82654001440 HSP70 interaction site [polypeptide binding]; other site 82654001441 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654001442 TPR repeat; Region: TPR_11; pfam13414 82654001443 binding surface 82654001444 TPR motif; other site 82654001445 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 82654001446 HSP70 interaction site [polypeptide binding]; other site 82654001447 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654001448 TPR motif; other site 82654001449 binding surface 82654001450 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 82654001451 putative active site [active] 82654001452 dimerization interface [polypeptide binding]; other site 82654001453 putative tRNAtyr binding site [nucleotide binding]; other site 82654001454 Phycobilisome protein; Region: Phycobilisome; cl08227 82654001455 photosystem I P700 chlorophyll a apoprotein A2; Region: psaB; CHL00054 82654001456 photosystem I P700 chlorophyll a apoprotein A1; Region: psaA; CHL00056 82654001457 Rhomboid family; Region: Rhomboid; pfam01694 82654001458 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 82654001459 Permease; Region: Permease; cl00510 82654001460 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 82654001461 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 82654001462 Competence protein; Region: Competence; pfam03772 82654001463 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 82654001464 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 82654001465 photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877 82654001466 arginine decarboxylase; Provisional; Region: PRK05354 82654001467 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 82654001468 active site 82654001469 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 82654001470 dimer interface [polypeptide binding]; other site 82654001471 catalytic residues [active] 82654001472 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 82654001473 Protein of unknown function (DUF561); Region: DUF561; pfam04481 82654001474 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 82654001475 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 82654001476 putative substrate binding site [chemical binding]; other site 82654001477 putative ATP binding site [chemical binding]; other site 82654001478 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001479 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654001480 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001481 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001482 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001483 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001484 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001485 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001486 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 82654001487 NifU-like domain; Region: NifU; pfam01106 82654001488 sucrose synthase; Region: sucr_synth; TIGR02470 82654001489 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 82654001490 putative ADP-binding pocket [chemical binding]; other site 82654001491 ribosomal protein L19; Region: rpl19; CHL00084 82654001492 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 82654001493 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 82654001494 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 82654001495 putative homodimer interface [polypeptide binding]; other site 82654001496 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 82654001497 heterodimer interface [polypeptide binding]; other site 82654001498 homodimer interface [polypeptide binding]; other site 82654001499 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 82654001500 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 82654001501 23S rRNA interface [nucleotide binding]; other site 82654001502 L7/L12 interface [polypeptide binding]; other site 82654001503 putative thiostrepton binding site; other site 82654001504 L25 interface [polypeptide binding]; other site 82654001505 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 82654001506 mRNA/rRNA interface [nucleotide binding]; other site 82654001507 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 82654001508 23S rRNA interface [nucleotide binding]; other site 82654001509 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 82654001510 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 82654001511 peripheral dimer interface [polypeptide binding]; other site 82654001512 core dimer interface [polypeptide binding]; other site 82654001513 L10 interface [polypeptide binding]; other site 82654001514 L11 interface [polypeptide binding]; other site 82654001515 putative EF-Tu interaction site [polypeptide binding]; other site 82654001516 putative EF-G interaction site [polypeptide binding]; other site 82654001517 Methyltransferase domain; Region: Methyltransf_23; pfam13489 82654001518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654001519 S-adenosylmethionine binding site [chemical binding]; other site 82654001520 AAA ATPase domain; Region: AAA_16; pfam13191 82654001521 FOG: WD40 repeat [General function prediction only]; Region: COG2319 82654001522 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 82654001523 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 82654001524 Tetratricopeptide repeat; Region: TPR_12; pfam13424 82654001525 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654001526 binding surface 82654001527 TPR motif; other site 82654001528 Predicted membrane protein [Function unknown]; Region: COG2259 82654001529 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 82654001530 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 82654001531 protein-splicing catalytic site; other site 82654001532 thioester formation/cholesterol transfer; other site 82654001533 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 82654001534 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 82654001535 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 82654001536 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 82654001537 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 82654001538 RNA binding surface [nucleotide binding]; other site 82654001539 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 82654001540 active site 82654001541 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 82654001542 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 82654001543 Surface antigen; Region: Bac_surface_Ag; pfam01103 82654001544 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 82654001545 MltA specific insert domain; Region: MltA; pfam03562 82654001546 3D domain; Region: 3D; pfam06725 82654001547 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 82654001548 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 82654001549 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 82654001550 active site 82654001551 OsmC-like protein; Region: OsmC; cl00767 82654001552 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 82654001553 Transcriptional regulator [Transcription]; Region: LytR; COG1316 82654001554 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 82654001555 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 82654001556 active site 82654001557 Substrate binding site; other site 82654001558 Mg++ binding site; other site 82654001559 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 82654001560 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 82654001561 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 82654001562 NAD(P) binding site [chemical binding]; other site 82654001563 homotetramer interface [polypeptide binding]; other site 82654001564 homodimer interface [polypeptide binding]; other site 82654001565 active site 82654001566 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 82654001567 active site 82654001568 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 82654001569 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 82654001570 putative active site [active] 82654001571 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 82654001572 putative active site [active] 82654001573 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 82654001574 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 82654001575 tetramer interface [polypeptide binding]; other site 82654001576 TPP-binding site [chemical binding]; other site 82654001577 heterodimer interface [polypeptide binding]; other site 82654001578 phosphorylation loop region [posttranslational modification] 82654001579 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 82654001580 Bacterial sugar transferase; Region: Bac_transf; pfam02397 82654001581 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 82654001582 TrkA-N domain; Region: TrkA_N; pfam02254 82654001583 TrkA-C domain; Region: TrkA_C; pfam02080 82654001584 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 82654001585 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 82654001586 UGMP family protein; Validated; Region: PRK09604 82654001587 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 82654001588 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 82654001589 photosystem I subunit IX; Region: psaJ; CHL00105 82654001590 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 82654001591 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 82654001592 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654001593 active site 82654001594 ATP binding site [chemical binding]; other site 82654001595 substrate binding site [chemical binding]; other site 82654001596 activation loop (A-loop); other site 82654001597 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 82654001598 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 82654001599 conserved hypothetical protein; Region: TIGR02231 82654001600 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 82654001601 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 82654001602 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 82654001603 Mechanosensitive ion channel; Region: MS_channel; pfam00924 82654001604 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 82654001605 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 82654001606 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 82654001607 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 82654001608 DDE superfamily endonuclease; Region: DDE_3; pfam13358 82654001609 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 82654001610 Homeodomain-like domain; Region: HTH_23; pfam13384 82654001611 Winged helix-turn helix; Region: HTH_29; pfam13551 82654001612 Winged helix-turn helix; Region: HTH_33; pfam13592 82654001613 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 82654001614 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 82654001615 GatB domain; Region: GatB_Yqey; smart00845 82654001616 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 82654001617 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 82654001618 photochlorophyllide reductase subunit L; Region: chlL; CHL00072 82654001619 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 82654001620 P-loop; other site 82654001621 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 82654001622 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 82654001623 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 82654001624 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 82654001625 E-class dimer interface [polypeptide binding]; other site 82654001626 P-class dimer interface [polypeptide binding]; other site 82654001627 active site 82654001628 Cu2+ binding site [ion binding]; other site 82654001629 Zn2+ binding site [ion binding]; other site 82654001630 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 82654001631 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 82654001632 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 82654001633 Bacterial Ig-like domain; Region: Big_5; pfam13205 82654001634 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 82654001635 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 82654001636 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 82654001637 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 82654001638 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 82654001639 Hexamer interface [polypeptide binding]; other site 82654001640 Hexagonal pore residue; other site 82654001641 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 82654001642 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 82654001643 Hexamer interface [polypeptide binding]; other site 82654001644 Hexagonal pore residue; other site 82654001645 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 82654001646 Uncharacterized conserved protein [Function unknown]; Region: COG1359 82654001647 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 82654001648 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 82654001649 NodB motif; other site 82654001650 active site 82654001651 catalytic site [active] 82654001652 metal binding site [ion binding]; metal-binding site 82654001653 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 82654001654 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 82654001655 active site 82654001656 MraW methylase family; Region: Methyltransf_5; cl17771 82654001657 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 82654001658 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 82654001659 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 82654001660 TRAM domain; Region: TRAM; pfam01938 82654001661 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 82654001662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654001663 active site 82654001664 phosphorylation site [posttranslational modification] 82654001665 intermolecular recognition site; other site 82654001666 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 82654001667 DNA binding residues [nucleotide binding] 82654001668 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 82654001669 ThiS interaction site; other site 82654001670 putative active site [active] 82654001671 tetramer interface [polypeptide binding]; other site 82654001672 Predicted transcriptional regulator [Transcription]; Region: COG1959 82654001673 Transcriptional regulator; Region: Rrf2; pfam02082 82654001674 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 82654001675 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 82654001676 dimer interface [polypeptide binding]; other site 82654001677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 82654001678 catalytic residue [active] 82654001679 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 82654001680 rRNA interaction site [nucleotide binding]; other site 82654001681 S8 interaction site; other site 82654001682 putative laminin-1 binding site; other site 82654001683 elongation factor Ts; Reviewed; Region: tsf; PRK12332 82654001684 UBA/TS-N domain; Region: UBA; pfam00627 82654001685 Elongation factor TS; Region: EF_TS; pfam00889 82654001686 Protein of unknown function DUF262; Region: DUF262; pfam03235 82654001687 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654001688 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654001689 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654001690 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654001691 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654001692 PAS domain; Region: PAS_9; pfam13426 82654001693 putative active site [active] 82654001694 heme pocket [chemical binding]; other site 82654001695 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 82654001696 cyclase homology domain; Region: CHD; cd07302 82654001697 nucleotidyl binding site; other site 82654001698 metal binding site [ion binding]; metal-binding site 82654001699 dimer interface [polypeptide binding]; other site 82654001700 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 82654001701 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 82654001702 active site 82654001703 HIGH motif; other site 82654001704 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 82654001705 active site 82654001706 KMSKS motif; other site 82654001707 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 82654001708 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 82654001709 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 82654001710 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 82654001711 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 82654001712 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 82654001713 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 82654001714 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 82654001715 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 82654001716 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 82654001717 Ligand binding site; other site 82654001718 Ligand binding site; other site 82654001719 Ligand binding site; other site 82654001720 Putative Catalytic site; other site 82654001721 DXD motif; other site 82654001722 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 82654001723 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 82654001724 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 82654001725 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 82654001726 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 82654001727 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 82654001728 Predicted membrane protein [Function unknown]; Region: COG2259 82654001729 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 82654001730 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 82654001731 interchain domain interface [polypeptide binding]; other site 82654001732 heme bL binding site [chemical binding]; other site 82654001733 intrachain domain interface; other site 82654001734 heme bH binding site [chemical binding]; other site 82654001735 Qo binding site; other site 82654001736 BolA-like protein; Region: BolA; pfam01722 82654001737 Response regulator receiver domain; Region: Response_reg; pfam00072 82654001738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654001739 active site 82654001740 phosphorylation site [posttranslational modification] 82654001741 intermolecular recognition site; other site 82654001742 dimerization interface [polypeptide binding]; other site 82654001743 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 82654001744 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 82654001745 substrate binding site [chemical binding]; other site 82654001746 ligand binding site [chemical binding]; other site 82654001747 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 82654001748 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 82654001749 HIGH motif; other site 82654001750 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 82654001751 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 82654001752 active site 82654001753 KMSKS motif; other site 82654001754 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 82654001755 tRNA binding surface [nucleotide binding]; other site 82654001756 anticodon binding site; other site 82654001757 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 82654001758 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 82654001759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654001760 Walker A/P-loop; other site 82654001761 ATP binding site [chemical binding]; other site 82654001762 Q-loop/lid; other site 82654001763 ABC transporter signature motif; other site 82654001764 Walker B; other site 82654001765 D-loop; other site 82654001766 H-loop/switch region; other site 82654001767 Response regulator receiver domain; Region: Response_reg; pfam00072 82654001768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654001769 active site 82654001770 phosphorylation site [posttranslational modification] 82654001771 intermolecular recognition site; other site 82654001772 dimerization interface [polypeptide binding]; other site 82654001773 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 82654001774 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 82654001775 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 82654001776 catalytic residue [active] 82654001777 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 82654001778 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 82654001779 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 82654001780 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 82654001781 RPB1 interaction site [polypeptide binding]; other site 82654001782 RPB10 interaction site [polypeptide binding]; other site 82654001783 RPB11 interaction site [polypeptide binding]; other site 82654001784 RPB3 interaction site [polypeptide binding]; other site 82654001785 RPB12 interaction site [polypeptide binding]; other site 82654001786 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 82654001787 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 82654001788 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 82654001789 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 82654001790 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 82654001791 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 82654001792 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 82654001793 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 82654001794 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 82654001795 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 82654001796 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 82654001797 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 82654001798 DNA binding site [nucleotide binding] 82654001799 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 82654001800 molecular chaperone DnaK; Provisional; Region: PRK13411 82654001801 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 82654001802 nucleotide binding site [chemical binding]; other site 82654001803 NEF interaction site [polypeptide binding]; other site 82654001804 SBD interface [polypeptide binding]; other site 82654001805 GrpE; Region: GrpE; pfam01025 82654001806 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 82654001807 dimer interface [polypeptide binding]; other site 82654001808 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 82654001809 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 82654001810 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 82654001811 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 82654001812 GSH binding site [chemical binding]; other site 82654001813 catalytic residues [active] 82654001814 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 82654001815 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 82654001816 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 82654001817 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 82654001818 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 82654001819 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 82654001820 metal binding site [ion binding]; metal-binding site 82654001821 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 82654001822 E3 interaction surface; other site 82654001823 lipoyl attachment site [posttranslational modification]; other site 82654001824 e3 binding domain; Region: E3_binding; pfam02817 82654001825 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 82654001826 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 82654001827 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 82654001828 classical (c) SDRs; Region: SDR_c; cd05233 82654001829 NAD(P) binding site [chemical binding]; other site 82654001830 active site 82654001831 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 82654001832 Dynamin family; Region: Dynamin_N; pfam00350 82654001833 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 82654001834 G1 box; other site 82654001835 GTP/Mg2+ binding site [chemical binding]; other site 82654001836 G2 box; other site 82654001837 Switch I region; other site 82654001838 G3 box; other site 82654001839 Switch II region; other site 82654001840 G4 box; other site 82654001841 G5 box; other site 82654001842 Domain of unknown function (DUF697); Region: DUF697; pfam05128 82654001843 Photosystem II complex subunit Ycf12; Region: PSII_Ycf12; cl12139 82654001844 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 82654001845 dimer interface [polypeptide binding]; other site 82654001846 [2Fe-2S] cluster binding site [ion binding]; other site 82654001847 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 82654001848 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 82654001849 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 82654001850 active site 82654001851 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 82654001852 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 82654001853 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 82654001854 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 82654001855 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 82654001856 amphipathic channel; other site 82654001857 Asn-Pro-Ala signature motifs; other site 82654001858 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 82654001859 putative DNA binding site [nucleotide binding]; other site 82654001860 dimerization interface [polypeptide binding]; other site 82654001861 putative Zn2+ binding site [ion binding]; other site 82654001862 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 82654001863 catalytic residue [active] 82654001864 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654001865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654001866 active site 82654001867 phosphorylation site [posttranslational modification] 82654001868 intermolecular recognition site; other site 82654001869 dimerization interface [polypeptide binding]; other site 82654001870 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654001871 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654001872 dimer interface [polypeptide binding]; other site 82654001873 phosphorylation site [posttranslational modification] 82654001874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654001875 ATP binding site [chemical binding]; other site 82654001876 Mg2+ binding site [ion binding]; other site 82654001877 G-X-G motif; other site 82654001878 FOG: CBS domain [General function prediction only]; Region: COG0517 82654001879 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 82654001880 PAS domain S-box; Region: sensory_box; TIGR00229 82654001881 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654001882 putative active site [active] 82654001883 heme pocket [chemical binding]; other site 82654001884 PAS domain S-box; Region: sensory_box; TIGR00229 82654001885 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654001886 putative active site [active] 82654001887 heme pocket [chemical binding]; other site 82654001888 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 82654001889 Histidine kinase; Region: HisKA_2; pfam07568 82654001890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654001891 ATP binding site [chemical binding]; other site 82654001892 Mg2+ binding site [ion binding]; other site 82654001893 G-X-G motif; other site 82654001894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 82654001895 BT1 family; Region: BT1; pfam03092 82654001896 putative substrate translocation pore; other site 82654001897 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 82654001898 Na binding site [ion binding]; other site 82654001899 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 82654001900 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 82654001901 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 82654001902 dimer interface [polypeptide binding]; other site 82654001903 substrate binding site [chemical binding]; other site 82654001904 ATP binding site [chemical binding]; other site 82654001905 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001906 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654001907 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001908 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654001909 S-layer homology domain; Region: SLH; pfam00395 82654001910 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 82654001911 Methyltransferase domain; Region: Methyltransf_23; pfam13489 82654001912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654001913 S-adenosylmethionine binding site [chemical binding]; other site 82654001914 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 82654001915 non-specific DNA binding site [nucleotide binding]; other site 82654001916 salt bridge; other site 82654001917 sequence-specific DNA binding site [nucleotide binding]; other site 82654001918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654001919 binding surface 82654001920 Tetratricopeptide repeat; Region: TPR_12; pfam13424 82654001921 TPR motif; other site 82654001922 Tetratricopeptide repeat; Region: TPR_12; pfam13424 82654001923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654001924 binding surface 82654001925 TPR motif; other site 82654001926 Tetratricopeptide repeat; Region: TPR_12; pfam13424 82654001927 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 82654001928 nudix motif; other site 82654001929 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 82654001930 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 82654001931 active site 82654001932 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 82654001933 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 82654001934 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 82654001935 active site 82654001936 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 82654001937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654001938 Walker A/P-loop; other site 82654001939 ATP binding site [chemical binding]; other site 82654001940 Q-loop/lid; other site 82654001941 ABC transporter signature motif; other site 82654001942 Walker B; other site 82654001943 D-loop; other site 82654001944 H-loop/switch region; other site 82654001945 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 82654001946 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 82654001947 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 82654001948 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 82654001949 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 82654001950 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 82654001951 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 82654001952 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654001953 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 82654001954 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 82654001955 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 82654001956 active site 82654001957 HIGH motif; other site 82654001958 nucleotide binding site [chemical binding]; other site 82654001959 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 82654001960 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 82654001961 active site 82654001962 KMSKS motif; other site 82654001963 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 82654001964 tRNA binding surface [nucleotide binding]; other site 82654001965 anticodon binding site; other site 82654001966 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 82654001967 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 82654001968 photosystem I assembly protein Ycf3; Region: ycf3; CHL00033 82654001969 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654001970 binding surface 82654001971 TPR motif; other site 82654001972 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 82654001973 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 82654001974 ribosomal protein L21; Region: rpl21; CHL00075 82654001975 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 82654001976 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 82654001977 Methyltransferase domain; Region: Methyltransf_31; pfam13847 82654001978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654001979 S-adenosylmethionine binding site [chemical binding]; other site 82654001980 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654001981 TPR motif; other site 82654001982 binding surface 82654001983 TPR repeat; Region: TPR_11; pfam13414 82654001984 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654001985 binding surface 82654001986 TPR motif; other site 82654001987 TPR repeat; Region: TPR_11; pfam13414 82654001988 TPR repeat; Region: TPR_11; pfam13414 82654001989 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654001990 binding surface 82654001991 TPR motif; other site 82654001992 TPR repeat; Region: TPR_11; pfam13414 82654001993 TPR repeat; Region: TPR_11; pfam13414 82654001994 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654001995 TPR motif; other site 82654001996 binding surface 82654001997 TPR repeat; Region: TPR_11; pfam13414 82654001998 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654001999 binding surface 82654002000 TPR motif; other site 82654002001 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 82654002002 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 82654002003 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 82654002004 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 82654002005 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 82654002006 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 82654002007 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 82654002008 Catalytic site [active] 82654002009 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 82654002010 aspartate kinase; Provisional; Region: PRK07431 82654002011 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 82654002012 putative catalytic residues [active] 82654002013 putative nucleotide binding site [chemical binding]; other site 82654002014 putative aspartate binding site [chemical binding]; other site 82654002015 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 82654002016 putative allosteric regulatory site; other site 82654002017 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 82654002018 putative allosteric regulatory residue; other site 82654002019 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 82654002020 putative allosteric regulatory site; other site 82654002021 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 82654002022 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 82654002023 phosphoglyceromutase; Provisional; Region: PRK05434 82654002024 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 82654002025 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 82654002026 ligand binding site [chemical binding]; other site 82654002027 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 82654002028 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 82654002029 Rab subfamily motif 1 (RabSF1); other site 82654002030 G1 box; other site 82654002031 GTP/Mg2+ binding site [chemical binding]; other site 82654002032 Rab subfamily motif 2 (RabSF2); other site 82654002033 Switch I region; other site 82654002034 G2 box; other site 82654002035 effector interaction site; other site 82654002036 GDI interaction site; other site 82654002037 Rab family motif 1 (RabF1); other site 82654002038 GEF interaction site [polypeptide binding]; other site 82654002039 Rab family motif 2 (RabF2); other site 82654002040 G3 box; other site 82654002041 Switch II region; other site 82654002042 Rab family motif 3 (RabF3); other site 82654002043 Rab family motif 4 (RabF4); other site 82654002044 Rab family motif 5 (RabF5); other site 82654002045 Rab subfamily motif 3 (RabSF3); other site 82654002046 G4 box; other site 82654002047 G5 box; other site 82654002048 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654002049 putative active site [active] 82654002050 PAS domain S-box; Region: sensory_box; TIGR00229 82654002051 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654002052 putative active site [active] 82654002053 heme pocket [chemical binding]; other site 82654002054 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 82654002055 cyclase homology domain; Region: CHD; cd07302 82654002056 nucleotidyl binding site; other site 82654002057 metal binding site [ion binding]; metal-binding site 82654002058 dimer interface [polypeptide binding]; other site 82654002059 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 82654002060 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 82654002061 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654002062 putative active site [active] 82654002063 heme pocket [chemical binding]; other site 82654002064 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654002065 dimer interface [polypeptide binding]; other site 82654002066 phosphorylation site [posttranslational modification] 82654002067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654002068 ATP binding site [chemical binding]; other site 82654002069 Mg2+ binding site [ion binding]; other site 82654002070 G-X-G motif; other site 82654002071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654002072 Response regulator receiver domain; Region: Response_reg; pfam00072 82654002073 active site 82654002074 phosphorylation site [posttranslational modification] 82654002075 intermolecular recognition site; other site 82654002076 dimerization interface [polypeptide binding]; other site 82654002077 Response regulator receiver domain; Region: Response_reg; pfam00072 82654002078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654002079 active site 82654002080 phosphorylation site [posttranslational modification] 82654002081 intermolecular recognition site; other site 82654002082 dimerization interface [polypeptide binding]; other site 82654002083 TMAO/DMSO reductase; Reviewed; Region: PRK05363 82654002084 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 82654002085 Moco binding site; other site 82654002086 metal coordination site [ion binding]; other site 82654002087 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 82654002088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654002089 active site 82654002090 phosphorylation site [posttranslational modification] 82654002091 intermolecular recognition site; other site 82654002092 dimerization interface [polypeptide binding]; other site 82654002093 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 82654002094 DNA binding site [nucleotide binding] 82654002095 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654002096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654002097 active site 82654002098 phosphorylation site [posttranslational modification] 82654002099 intermolecular recognition site; other site 82654002100 dimerization interface [polypeptide binding]; other site 82654002101 PAS domain S-box; Region: sensory_box; TIGR00229 82654002102 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654002103 putative active site [active] 82654002104 heme pocket [chemical binding]; other site 82654002105 GAF domain; Region: GAF; cl17456 82654002106 PAS domain S-box; Region: sensory_box; TIGR00229 82654002107 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654002108 putative active site [active] 82654002109 heme pocket [chemical binding]; other site 82654002110 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 82654002111 PAS domain; Region: PAS_9; pfam13426 82654002112 putative active site [active] 82654002113 heme pocket [chemical binding]; other site 82654002114 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654002115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654002116 dimer interface [polypeptide binding]; other site 82654002117 phosphorylation site [posttranslational modification] 82654002118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654002119 ATP binding site [chemical binding]; other site 82654002120 G-X-G motif; other site 82654002121 Amino acid permease; Region: AA_permease_2; pfam13520 82654002122 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 82654002123 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 82654002124 TAP-like protein; Region: Abhydrolase_4; pfam08386 82654002125 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654002126 putative active site [active] 82654002127 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 82654002128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654002129 Walker A/P-loop; other site 82654002130 ATP binding site [chemical binding]; other site 82654002131 Q-loop/lid; other site 82654002132 ABC transporter signature motif; other site 82654002133 Walker B; other site 82654002134 D-loop; other site 82654002135 H-loop/switch region; other site 82654002136 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 82654002137 Uncharacterized conserved protein [Function unknown]; Region: COG1262 82654002138 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 82654002139 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 82654002140 catalytic residues [active] 82654002141 beta-lactamase TEM; Provisional; Region: PRK15442 82654002142 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 82654002143 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 82654002144 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 82654002145 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 82654002146 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 82654002147 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 82654002148 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 82654002149 putative active site [active] 82654002150 putative metal binding site [ion binding]; other site 82654002151 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 82654002152 Uncharacterized conserved protein [Function unknown]; Region: COG1434 82654002153 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 82654002154 putative active site [active] 82654002155 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 82654002156 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 82654002157 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 82654002158 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 82654002159 EamA-like transporter family; Region: EamA; pfam00892 82654002160 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 82654002161 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 82654002162 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 82654002163 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 82654002164 Sm and related proteins; Region: Sm_like; cl00259 82654002165 heptamer interface [polypeptide binding]; other site 82654002166 Sm1 motif; other site 82654002167 hexamer interface [polypeptide binding]; other site 82654002168 RNA binding site [nucleotide binding]; other site 82654002169 Sm2 motif; other site 82654002170 cobyric acid synthase; Provisional; Region: PRK00784 82654002171 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 82654002172 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 82654002173 catalytic triad [active] 82654002174 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 82654002175 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 82654002176 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 82654002177 cell division protein; Validated; Region: ftsH; CHL00176 82654002178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654002179 Walker A motif; other site 82654002180 ATP binding site [chemical binding]; other site 82654002181 Walker B motif; other site 82654002182 arginine finger; other site 82654002183 Peptidase family M41; Region: Peptidase_M41; pfam01434 82654002184 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 82654002185 tellurite resistance protein terB; Region: terB; cd07176 82654002186 putative metal binding site [ion binding]; other site 82654002187 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 82654002188 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654002189 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654002190 dimer interface [polypeptide binding]; other site 82654002191 phosphorylation site [posttranslational modification] 82654002192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654002193 ATP binding site [chemical binding]; other site 82654002194 Mg2+ binding site [ion binding]; other site 82654002195 G-X-G motif; other site 82654002196 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 82654002197 ATP-NAD kinase; Region: NAD_kinase; pfam01513 82654002198 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 82654002199 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 82654002200 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 82654002201 catalytic residue [active] 82654002202 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 82654002203 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 82654002204 trimer interface [polypeptide binding]; other site 82654002205 dimer interface [polypeptide binding]; other site 82654002206 putative active site [active] 82654002207 Protein of unknown function (DUF2459); Region: DUF2459; cl09819 82654002208 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 82654002209 nudix motif; other site 82654002210 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 82654002211 Protein phosphatase 2C; Region: PP2C_2; pfam13672 82654002212 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 82654002213 catalytic triad [active] 82654002214 conserved cis-peptide bond; other site 82654002215 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 82654002216 Mechanosensitive ion channel; Region: MS_channel; pfam00924 82654002217 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 82654002218 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 82654002219 putative NAD(P) binding site [chemical binding]; other site 82654002220 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 82654002221 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 82654002222 active site 82654002223 ATP binding site [chemical binding]; other site 82654002224 substrate binding site [chemical binding]; other site 82654002225 activation loop (A-loop); other site 82654002226 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 82654002227 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 82654002228 active site 82654002229 metal binding site [ion binding]; metal-binding site 82654002230 DNA binding site [nucleotide binding] 82654002231 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 82654002232 Type III pantothenate kinase; Region: Pan_kinase; cl17198 82654002233 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 82654002234 anti sigma factor interaction site; other site 82654002235 regulatory phosphorylation site [posttranslational modification]; other site 82654002236 Poliovirus 3A protein like; Region: P3A; pfam08727 82654002237 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 82654002238 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 82654002239 active site 82654002240 SAM binding site [chemical binding]; other site 82654002241 homodimer interface [polypeptide binding]; other site 82654002242 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 82654002243 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 82654002244 active site 82654002245 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 82654002246 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 82654002247 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 82654002248 metal ion-dependent adhesion site (MIDAS); other site 82654002249 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654002250 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002251 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002252 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002253 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002254 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002255 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 82654002256 putative binding surface; other site 82654002257 active site 82654002258 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 82654002259 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 82654002260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654002261 ATP binding site [chemical binding]; other site 82654002262 Mg2+ binding site [ion binding]; other site 82654002263 G-X-G motif; other site 82654002264 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 82654002265 Response regulator receiver domain; Region: Response_reg; pfam00072 82654002266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654002267 active site 82654002268 phosphorylation site [posttranslational modification] 82654002269 intermolecular recognition site; other site 82654002270 dimerization interface [polypeptide binding]; other site 82654002271 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 82654002272 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 82654002273 substrate binding pocket [chemical binding]; other site 82654002274 membrane-bound complex binding site; other site 82654002275 hinge residues; other site 82654002276 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 82654002277 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 82654002278 dimer interface [polypeptide binding]; other site 82654002279 putative CheW interface [polypeptide binding]; other site 82654002280 HAMP domain; Region: HAMP; pfam00672 82654002281 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 82654002282 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 82654002283 dimer interface [polypeptide binding]; other site 82654002284 putative CheW interface [polypeptide binding]; other site 82654002285 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 82654002286 Response regulator receiver domain; Region: Response_reg; pfam00072 82654002287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654002288 active site 82654002289 phosphorylation site [posttranslational modification] 82654002290 intermolecular recognition site; other site 82654002291 dimerization interface [polypeptide binding]; other site 82654002292 Response regulator receiver domain; Region: Response_reg; pfam00072 82654002293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654002294 active site 82654002295 phosphorylation site [posttranslational modification] 82654002296 intermolecular recognition site; other site 82654002297 dimerization interface [polypeptide binding]; other site 82654002298 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 82654002299 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654002300 active site 82654002301 ATP binding site [chemical binding]; other site 82654002302 substrate binding site [chemical binding]; other site 82654002303 activation loop (A-loop); other site 82654002304 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 82654002305 IHF - DNA interface [nucleotide binding]; other site 82654002306 IHF dimer interface [polypeptide binding]; other site 82654002307 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 82654002308 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 82654002309 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 82654002310 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 82654002311 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 82654002312 RimM N-terminal domain; Region: RimM; pfam01782 82654002313 PRC-barrel domain; Region: PRC; pfam05239 82654002314 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 82654002315 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 82654002316 putative ribose interaction site [chemical binding]; other site 82654002317 putative ADP binding site [chemical binding]; other site 82654002318 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 82654002319 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 82654002320 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 82654002321 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 82654002322 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 82654002323 dimer interface [polypeptide binding]; other site 82654002324 active site 82654002325 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 82654002326 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 82654002327 nucleotide binding site [chemical binding]; other site 82654002328 putative NEF/HSP70 interaction site [polypeptide binding]; other site 82654002329 SBD interface [polypeptide binding]; other site 82654002330 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 82654002331 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 82654002332 FtsX-like permease family; Region: FtsX; pfam02687 82654002333 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 82654002334 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 82654002335 Walker A/P-loop; other site 82654002336 ATP binding site [chemical binding]; other site 82654002337 Q-loop/lid; other site 82654002338 ABC transporter signature motif; other site 82654002339 Walker B; other site 82654002340 D-loop; other site 82654002341 H-loop/switch region; other site 82654002342 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 82654002343 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 82654002344 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654002345 active site 82654002346 ATP binding site [chemical binding]; other site 82654002347 substrate binding site [chemical binding]; other site 82654002348 activation loop (A-loop); other site 82654002349 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 82654002350 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654002351 active site 82654002352 ATP binding site [chemical binding]; other site 82654002353 substrate binding site [chemical binding]; other site 82654002354 activation loop (A-loop); other site 82654002355 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654002356 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002357 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002358 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002359 S-layer homology domain; Region: SLH; pfam00395 82654002360 S-layer homology domain; Region: SLH; pfam00395 82654002361 S-layer homology domain; Region: SLH; pfam00395 82654002362 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 82654002363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 82654002364 Protein of unknown function DUF86; Region: DUF86; cl01031 82654002365 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 82654002366 PLD-like domain; Region: PLDc_2; pfam13091 82654002367 putative active site [active] 82654002368 catalytic site [active] 82654002369 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 82654002370 PLD-like domain; Region: PLDc_2; pfam13091 82654002371 putative active site [active] 82654002372 catalytic site [active] 82654002373 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 82654002374 anti sigma factor interaction site; other site 82654002375 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 82654002376 regulatory phosphorylation site [posttranslational modification]; other site 82654002377 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 82654002378 catalytic core [active] 82654002379 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 82654002380 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 82654002381 TPR motif; other site 82654002382 binding surface 82654002383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654002384 TPR motif; other site 82654002385 Tetratricopeptide repeat; Region: TPR_12; pfam13424 82654002386 binding surface 82654002387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 82654002388 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 82654002389 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 82654002390 NADP binding site [chemical binding]; other site 82654002391 active site 82654002392 putative substrate binding site [chemical binding]; other site 82654002393 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 82654002394 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654002395 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 82654002396 putative active site [active] 82654002397 heme pocket [chemical binding]; other site 82654002398 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654002399 putative active site [active] 82654002400 heme pocket [chemical binding]; other site 82654002401 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654002402 GAF domain; Region: GAF; pfam01590 82654002403 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654002404 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654002405 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654002406 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654002407 dimer interface [polypeptide binding]; other site 82654002408 phosphorylation site [posttranslational modification] 82654002409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654002410 ATP binding site [chemical binding]; other site 82654002411 Mg2+ binding site [ion binding]; other site 82654002412 G-X-G motif; other site 82654002413 Response regulator receiver domain; Region: Response_reg; pfam00072 82654002414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654002415 active site 82654002416 phosphorylation site [posttranslational modification] 82654002417 intermolecular recognition site; other site 82654002418 dimerization interface [polypeptide binding]; other site 82654002419 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654002420 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654002421 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654002422 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654002423 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654002424 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654002425 dimer interface [polypeptide binding]; other site 82654002426 phosphorylation site [posttranslational modification] 82654002427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654002428 ATP binding site [chemical binding]; other site 82654002429 Mg2+ binding site [ion binding]; other site 82654002430 G-X-G motif; other site 82654002431 Response regulator receiver domain; Region: Response_reg; pfam00072 82654002432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654002433 active site 82654002434 phosphorylation site [posttranslational modification] 82654002435 intermolecular recognition site; other site 82654002436 dimerization interface [polypeptide binding]; other site 82654002437 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 82654002438 cyclase homology domain; Region: CHD; cd07302 82654002439 nucleotidyl binding site; other site 82654002440 metal binding site [ion binding]; metal-binding site 82654002441 dimer interface [polypeptide binding]; other site 82654002442 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 82654002443 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 82654002444 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 82654002445 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 82654002446 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 82654002447 Photosystem II reaction centre X protein (PsbX); Region: PsbX; cl05887 82654002448 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 82654002449 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 82654002450 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654002451 active site 82654002452 ATP binding site [chemical binding]; other site 82654002453 substrate binding site [chemical binding]; other site 82654002454 activation loop (A-loop); other site 82654002455 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654002456 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002457 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002458 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002459 YCII-related domain; Region: YCII; cl00999 82654002460 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 82654002461 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 82654002462 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 82654002463 active site 82654002464 nucleotide binding site [chemical binding]; other site 82654002465 HIGH motif; other site 82654002466 KMSKS motif; other site 82654002467 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 82654002468 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 82654002469 Coenzyme A binding pocket [chemical binding]; other site 82654002470 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 82654002471 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002472 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654002473 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002474 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002475 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 82654002476 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 82654002477 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 82654002478 Ligand Binding Site [chemical binding]; other site 82654002479 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 82654002480 Ligand Binding Site [chemical binding]; other site 82654002481 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 82654002482 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 82654002483 Coenzyme A binding pocket [chemical binding]; other site 82654002484 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654002485 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002486 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002487 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002488 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654002489 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002490 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002491 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 82654002492 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 82654002493 dimerization interface [polypeptide binding]; other site 82654002494 DPS ferroxidase diiron center [ion binding]; other site 82654002495 ion pore; other site 82654002496 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 82654002497 dimer interface [polypeptide binding]; other site 82654002498 [2Fe-2S] cluster binding site [ion binding]; other site 82654002499 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 82654002500 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 82654002501 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 82654002502 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 82654002503 metal binding site [ion binding]; metal-binding site 82654002504 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 82654002505 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 82654002506 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 82654002507 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 82654002508 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 82654002509 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 82654002510 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 82654002511 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 82654002512 active site 82654002513 substrate binding site [chemical binding]; other site 82654002514 metal binding site [ion binding]; metal-binding site 82654002515 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 82654002516 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 82654002517 23S rRNA binding site [nucleotide binding]; other site 82654002518 L21 binding site [polypeptide binding]; other site 82654002519 L13 binding site [polypeptide binding]; other site 82654002520 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 82654002521 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 82654002522 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 82654002523 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 82654002524 YceG-like family; Region: YceG; pfam02618 82654002525 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 82654002526 dimerization interface [polypeptide binding]; other site 82654002527 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 82654002528 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 82654002529 active site 82654002530 motif I; other site 82654002531 motif II; other site 82654002532 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 82654002533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654002534 active site 82654002535 phosphorylation site [posttranslational modification] 82654002536 intermolecular recognition site; other site 82654002537 dimerization interface [polypeptide binding]; other site 82654002538 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 82654002539 DNA binding site [nucleotide binding] 82654002540 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 82654002541 putative GSH binding site [chemical binding]; other site 82654002542 catalytic residues [active] 82654002543 FtsH Extracellular; Region: FtsH_ext; pfam06480 82654002544 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 82654002545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654002546 Walker A motif; other site 82654002547 ATP binding site [chemical binding]; other site 82654002548 Walker B motif; other site 82654002549 arginine finger; other site 82654002550 Peptidase family M41; Region: Peptidase_M41; pfam01434 82654002551 PAS domain; Region: PAS_9; pfam13426 82654002552 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654002553 PAS domain; Region: PAS_9; pfam13426 82654002554 putative active site [active] 82654002555 heme pocket [chemical binding]; other site 82654002556 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 82654002557 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654002558 putative active site [active] 82654002559 heme pocket [chemical binding]; other site 82654002560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654002561 dimer interface [polypeptide binding]; other site 82654002562 phosphorylation site [posttranslational modification] 82654002563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654002564 ATP binding site [chemical binding]; other site 82654002565 Mg2+ binding site [ion binding]; other site 82654002566 G-X-G motif; other site 82654002567 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 82654002568 putative active site [active] 82654002569 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 82654002570 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 82654002571 Septum formation topological specificity factor MinE; Region: MinE; cl00538 82654002572 septum site-determining protein MinD; Region: minD_bact; TIGR01968 82654002573 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 82654002574 Switch I; other site 82654002575 Switch II; other site 82654002576 septum formation inhibitor; Reviewed; Region: minC; PRK00513 82654002577 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 82654002578 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 82654002579 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 82654002580 GTP-binding protein YchF; Reviewed; Region: PRK09601 82654002581 YchF GTPase; Region: YchF; cd01900 82654002582 G1 box; other site 82654002583 GTP/Mg2+ binding site [chemical binding]; other site 82654002584 Switch I region; other site 82654002585 G2 box; other site 82654002586 Switch II region; other site 82654002587 G3 box; other site 82654002588 G4 box; other site 82654002589 G5 box; other site 82654002590 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 82654002591 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 82654002592 Protein of unknown function (DUF433); Region: DUF433; pfam04255 82654002593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 82654002594 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 82654002595 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 82654002596 active site 82654002597 metal binding site [ion binding]; metal-binding site 82654002598 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 82654002599 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 82654002600 DHH family; Region: DHH; pfam01368 82654002601 adaptive-response sensory kinase; Validated; Region: PRK09303 82654002602 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 82654002603 tetramer interface [polypeptide binding]; other site 82654002604 dimer interface [polypeptide binding]; other site 82654002605 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654002606 dimer interface [polypeptide binding]; other site 82654002607 phosphorylation site [posttranslational modification] 82654002608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654002609 ATP binding site [chemical binding]; other site 82654002610 Mg2+ binding site [ion binding]; other site 82654002611 G-X-G motif; other site 82654002612 Predicted membrane protein (DUF2335); Region: DUF2335; pfam10097 82654002613 Uncharacterized conserved protein [Function unknown]; Region: COG3379 82654002614 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 82654002615 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 82654002616 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 82654002617 circadian clock protein KaiC; Reviewed; Region: PRK09302 82654002618 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 82654002619 Walker A motif; other site 82654002620 ATP binding site [chemical binding]; other site 82654002621 Walker B motif; other site 82654002622 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 82654002623 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 82654002624 Walker A motif; other site 82654002625 Walker A motif; other site 82654002626 ATP binding site [chemical binding]; other site 82654002627 Walker B motif; other site 82654002628 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 82654002629 tetramer interface [polypeptide binding]; other site 82654002630 dimer interface [polypeptide binding]; other site 82654002631 KaiA domain; Region: KaiA; pfam07688 82654002632 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 82654002633 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654002634 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654002635 dimer interface [polypeptide binding]; other site 82654002636 phosphorylation site [posttranslational modification] 82654002637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654002638 ATP binding site [chemical binding]; other site 82654002639 Mg2+ binding site [ion binding]; other site 82654002640 G-X-G motif; other site 82654002641 Response regulator receiver domain; Region: Response_reg; pfam00072 82654002642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654002643 active site 82654002644 phosphorylation site [posttranslational modification] 82654002645 intermolecular recognition site; other site 82654002646 dimerization interface [polypeptide binding]; other site 82654002647 Protein of unknown function (DUF1517); Region: DUF1517; pfam07466 82654002648 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 82654002649 photosystem II 47 kDa protein; Region: psbB; CHL00062 82654002650 Response regulator receiver domain; Region: Response_reg; pfam00072 82654002651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654002652 active site 82654002653 phosphorylation site [posttranslational modification] 82654002654 intermolecular recognition site; other site 82654002655 dimerization interface [polypeptide binding]; other site 82654002656 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654002657 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654002658 phosphorylation site [posttranslational modification] 82654002659 dimer interface [polypeptide binding]; other site 82654002660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654002661 ATP binding site [chemical binding]; other site 82654002662 Mg2+ binding site [ion binding]; other site 82654002663 G-X-G motif; other site 82654002664 hypothetical protein; Reviewed; Region: PRK00024 82654002665 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 82654002666 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 82654002667 MPN+ (JAMM) motif; other site 82654002668 Zinc-binding site [ion binding]; other site 82654002669 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 82654002670 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 82654002671 dimerization interface [polypeptide binding]; other site 82654002672 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 82654002673 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 82654002674 UbiA prenyltransferase family; Region: UbiA; pfam01040 82654002675 CP12 domain; Region: CP12; pfam02672 82654002676 Phycobilisome protein; Region: Phycobilisome; cl08227 82654002677 threonine synthase; Reviewed; Region: PRK06721 82654002678 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 82654002679 homodimer interface [polypeptide binding]; other site 82654002680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 82654002681 catalytic residue [active] 82654002682 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 82654002683 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 82654002684 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 82654002685 Mechanosensitive ion channel; Region: MS_channel; pfam00924 82654002686 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371 82654002687 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 82654002688 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 82654002689 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654002690 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 82654002691 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654002692 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002693 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654002694 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002695 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002696 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002697 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 82654002698 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 82654002699 Ferredoxin [Energy production and conversion]; Region: COG1146 82654002700 ribosome maturation protein RimP; Reviewed; Region: PRK00092 82654002701 Sm and related proteins; Region: Sm_like; cl00259 82654002702 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 82654002703 putative oligomer interface [polypeptide binding]; other site 82654002704 putative RNA binding site [nucleotide binding]; other site 82654002705 NusA N-terminal domain; Region: NusA_N; pfam08529 82654002706 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 82654002707 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 82654002708 RNA binding site [nucleotide binding]; other site 82654002709 homodimer interface [polypeptide binding]; other site 82654002710 NusA-like KH domain; Region: KH_5; pfam13184 82654002711 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 82654002712 G-X-X-G motif; other site 82654002713 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 82654002714 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 82654002715 SnoaL-like domain; Region: SnoaL_3; pfam13474 82654002716 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 82654002717 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 82654002718 active site 82654002719 Zn binding site [ion binding]; other site 82654002720 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 82654002721 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 82654002722 nucleotide binding site [chemical binding]; other site 82654002723 NEF interaction site [polypeptide binding]; other site 82654002724 SBD interface [polypeptide binding]; other site 82654002725 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 82654002726 photosystem I subunit VII; Region: psaC; CHL00065 82654002727 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 82654002728 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 82654002729 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 82654002730 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 82654002731 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 82654002732 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 82654002733 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 82654002734 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 82654002735 Rhomboid family; Region: Rhomboid; pfam01694 82654002736 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 82654002737 active site 82654002738 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 82654002739 Response regulator receiver domain; Region: Response_reg; pfam00072 82654002740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654002741 active site 82654002742 phosphorylation site [posttranslational modification] 82654002743 intermolecular recognition site; other site 82654002744 dimerization interface [polypeptide binding]; other site 82654002745 ribonuclease Z; Region: RNase_Z; TIGR02651 82654002746 Gryzun, putative trafficking through Golgi; Region: Gryzun; pfam07919 82654002747 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 82654002748 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 82654002749 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 82654002750 HSP70 interaction site [polypeptide binding]; other site 82654002751 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 82654002752 phosphatidate cytidylyltransferase; Region: PLN02953 82654002753 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 82654002754 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 82654002755 RNA polymerase sigma factor; Provisional; Region: PRK12519 82654002756 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 82654002757 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 82654002758 DNA binding residues [nucleotide binding] 82654002759 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 82654002760 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 82654002761 putative NAD(P) binding site [chemical binding]; other site 82654002762 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 82654002763 active site 82654002764 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 82654002765 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 82654002766 dimer interface [polypeptide binding]; other site 82654002767 substrate binding site [chemical binding]; other site 82654002768 metal binding sites [ion binding]; metal-binding site 82654002769 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 82654002770 HSP70 interaction site [polypeptide binding]; other site 82654002771 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 82654002772 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 82654002773 substrate binding site [chemical binding]; other site 82654002774 glutamase interaction surface [polypeptide binding]; other site 82654002775 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 82654002776 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 82654002777 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 82654002778 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 82654002779 Ligand Binding Site [chemical binding]; other site 82654002780 Protein kinase domain; Region: Pkinase; pfam00069 82654002781 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654002782 active site 82654002783 ATP binding site [chemical binding]; other site 82654002784 substrate binding site [chemical binding]; other site 82654002785 activation loop (A-loop); other site 82654002786 AAA ATPase domain; Region: AAA_16; pfam13191 82654002787 Predicted ATPase [General function prediction only]; Region: COG3899 82654002788 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654002789 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654002790 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 82654002791 cyclase homology domain; Region: CHD; cd07302 82654002792 nucleotidyl binding site; other site 82654002793 metal binding site [ion binding]; metal-binding site 82654002794 dimer interface [polypeptide binding]; other site 82654002795 Cache domain; Region: Cache_1; pfam02743 82654002796 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 82654002797 dimerization interface [polypeptide binding]; other site 82654002798 PAS fold; Region: PAS_4; pfam08448 82654002799 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654002800 putative active site [active] 82654002801 heme pocket [chemical binding]; other site 82654002802 PAS fold; Region: PAS_4; pfam08448 82654002803 PAS domain S-box; Region: sensory_box; TIGR00229 82654002804 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654002805 putative active site [active] 82654002806 heme pocket [chemical binding]; other site 82654002807 PAS fold; Region: PAS_4; pfam08448 82654002808 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654002809 GAF domain; Region: GAF; pfam01590 82654002810 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654002811 dimer interface [polypeptide binding]; other site 82654002812 phosphorylation site [posttranslational modification] 82654002813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654002814 ATP binding site [chemical binding]; other site 82654002815 Mg2+ binding site [ion binding]; other site 82654002816 G-X-G motif; other site 82654002817 Response regulator receiver domain; Region: Response_reg; pfam00072 82654002818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654002819 active site 82654002820 phosphorylation site [posttranslational modification] 82654002821 intermolecular recognition site; other site 82654002822 dimerization interface [polypeptide binding]; other site 82654002823 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 82654002824 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 82654002825 acyl carrier protein; Provisional; Region: acpP; PRK00982 82654002826 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 82654002827 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 82654002828 dimer interface [polypeptide binding]; other site 82654002829 active site 82654002830 Rubredoxin [Energy production and conversion]; Region: COG1773 82654002831 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 82654002832 iron binding site [ion binding]; other site 82654002833 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 82654002834 isocitrate dehydrogenase; Validated; Region: PRK06451 82654002835 RNA polymerase sigma factor; Validated; Region: PRK05949 82654002836 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 82654002837 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 82654002838 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 82654002839 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 82654002840 DNA binding residues [nucleotide binding] 82654002841 30S ribosomal protein S1; Reviewed; Region: PRK07400 82654002842 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 82654002843 RNA binding site [nucleotide binding]; other site 82654002844 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 82654002845 RNA binding site [nucleotide binding]; other site 82654002846 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 82654002847 RNA binding site [nucleotide binding]; other site 82654002848 Clp protease; Region: CLP_protease; pfam00574 82654002849 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 82654002850 oligomer interface [polypeptide binding]; other site 82654002851 active site residues [active] 82654002852 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 82654002853 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 82654002854 oligomer interface [polypeptide binding]; other site 82654002855 active site residues [active] 82654002856 Domain of unknown function DUF302; Region: DUF302; pfam03625 82654002857 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 82654002858 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 82654002859 Ycf35; Provisional; Region: ycf35; CHL00193 82654002860 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 82654002861 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 82654002862 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 82654002863 Asparaginase [Amino acid transport and metabolism]; Region: COG1446 82654002864 active site 82654002865 dimer interface [polypeptide binding]; other site 82654002866 catalytic nucleophile [active] 82654002867 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 82654002868 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 82654002869 putative NAD(P) binding site [chemical binding]; other site 82654002870 putative substrate binding site [chemical binding]; other site 82654002871 catalytic Zn binding site [ion binding]; other site 82654002872 structural Zn binding site [ion binding]; other site 82654002873 dimer interface [polypeptide binding]; other site 82654002874 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 82654002875 active site 82654002876 DNA binding site [nucleotide binding] 82654002877 DNA repair protein RadA; Provisional; Region: PRK11823 82654002878 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 82654002879 Walker A motif; other site 82654002880 ATP binding site [chemical binding]; other site 82654002881 Walker B motif; other site 82654002882 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 82654002883 Helix-turn-helix domain; Region: HTH_25; pfam13413 82654002884 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 82654002885 enolase; Provisional; Region: eno; PRK00077 82654002886 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 82654002887 dimer interface [polypeptide binding]; other site 82654002888 metal binding site [ion binding]; metal-binding site 82654002889 substrate binding pocket [chemical binding]; other site 82654002890 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 82654002891 Mechanosensitive ion channel; Region: MS_channel; pfam00924 82654002892 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 82654002893 IHF - DNA interface [nucleotide binding]; other site 82654002894 IHF dimer interface [polypeptide binding]; other site 82654002895 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 82654002896 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 82654002897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 82654002898 homodimer interface [polypeptide binding]; other site 82654002899 catalytic residue [active] 82654002900 lipoyl synthase; Provisional; Region: PRK12928 82654002901 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 82654002902 FeS/SAM binding site; other site 82654002903 Response regulator receiver domain; Region: Response_reg; pfam00072 82654002904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654002905 active site 82654002906 phosphorylation site [posttranslational modification] 82654002907 intermolecular recognition site; other site 82654002908 dimerization interface [polypeptide binding]; other site 82654002909 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654002910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654002911 active site 82654002912 phosphorylation site [posttranslational modification] 82654002913 intermolecular recognition site; other site 82654002914 dimerization interface [polypeptide binding]; other site 82654002915 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 82654002916 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 82654002917 L-asparaginase II; Region: Asparaginase_II; pfam06089 82654002918 hydrolase, alpha/beta fold family protein; Region: PLN02824 82654002919 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 82654002920 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 82654002921 MOSC domain; Region: MOSC; pfam03473 82654002922 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 82654002923 Cache domain; Region: Cache_1; pfam02743 82654002924 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 82654002925 dimerization interface [polypeptide binding]; other site 82654002926 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 82654002927 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654002928 putative active site [active] 82654002929 heme pocket [chemical binding]; other site 82654002930 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654002931 dimer interface [polypeptide binding]; other site 82654002932 phosphorylation site [posttranslational modification] 82654002933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654002934 ATP binding site [chemical binding]; other site 82654002935 Mg2+ binding site [ion binding]; other site 82654002936 G-X-G motif; other site 82654002937 Response regulator receiver domain; Region: Response_reg; pfam00072 82654002938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654002939 active site 82654002940 phosphorylation site [posttranslational modification] 82654002941 intermolecular recognition site; other site 82654002942 dimerization interface [polypeptide binding]; other site 82654002943 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 82654002944 ribosomal protein S14; Region: rps14; CHL00074 82654002945 Gas vesicle protein; Region: Gas_vesicle; pfam00741 82654002946 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 82654002947 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654002948 Walker A motif; other site 82654002949 ATP binding site [chemical binding]; other site 82654002950 Walker B motif; other site 82654002951 arginine finger; other site 82654002952 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 82654002953 Circadian oscillating protein COP23; Region: COP23; pfam14218 82654002954 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 82654002955 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 82654002956 aspartate aminotransferase; Provisional; Region: PRK05764 82654002957 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 82654002958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 82654002959 homodimer interface [polypeptide binding]; other site 82654002960 catalytic residue [active] 82654002961 Cache domain; Region: Cache_1; pfam02743 82654002962 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 82654002963 dimerization interface [polypeptide binding]; other site 82654002964 PAS fold; Region: PAS_3; pfam08447 82654002965 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654002966 heme pocket [chemical binding]; other site 82654002967 putative active site [active] 82654002968 PAS domain S-box; Region: sensory_box; TIGR00229 82654002969 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654002970 putative active site [active] 82654002971 heme pocket [chemical binding]; other site 82654002972 PAS domain; Region: PAS; smart00091 82654002973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654002974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654002975 dimer interface [polypeptide binding]; other site 82654002976 phosphorylation site [posttranslational modification] 82654002977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654002978 ATP binding site [chemical binding]; other site 82654002979 Mg2+ binding site [ion binding]; other site 82654002980 G-X-G motif; other site 82654002981 PAS fold; Region: PAS_4; pfam08448 82654002982 PAS domain; Region: PAS_9; pfam13426 82654002983 PAS fold; Region: PAS_4; pfam08448 82654002984 PAS domain S-box; Region: sensory_box; TIGR00229 82654002985 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654002986 putative active site [active] 82654002987 heme pocket [chemical binding]; other site 82654002988 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 82654002989 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 82654002990 metal binding site [ion binding]; metal-binding site 82654002991 active site 82654002992 I-site; other site 82654002993 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 82654002994 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002995 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654002996 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002997 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654002998 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654002999 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654003000 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654003001 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654003002 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654003003 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 82654003004 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654003005 Walker A/P-loop; other site 82654003006 ATP binding site [chemical binding]; other site 82654003007 Q-loop/lid; other site 82654003008 ABC transporter signature motif; other site 82654003009 Walker B; other site 82654003010 D-loop; other site 82654003011 H-loop/switch region; other site 82654003012 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 82654003013 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 82654003014 putative acyl transferase; Provisional; Region: PRK10502 82654003015 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 82654003016 putative trimer interface [polypeptide binding]; other site 82654003017 putative active site [active] 82654003018 putative substrate binding site [chemical binding]; other site 82654003019 putative CoA binding site [chemical binding]; other site 82654003020 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654003021 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 82654003022 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 82654003023 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 82654003024 Mechanosensitive ion channel; Region: MS_channel; pfam00924 82654003025 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 82654003026 ligand binding site [chemical binding]; other site 82654003027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 82654003028 Tetratricopeptide repeat; Region: TPR_16; pfam13432 82654003029 binding surface 82654003030 TPR motif; other site 82654003031 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 82654003032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 82654003033 TPR motif; other site 82654003034 binding surface 82654003035 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 82654003036 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654003037 TPR motif; other site 82654003038 binding surface 82654003039 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 82654003040 PAS fold; Region: PAS_4; pfam08448 82654003041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654003042 putative active site [active] 82654003043 heme pocket [chemical binding]; other site 82654003044 PAS fold; Region: PAS_4; pfam08448 82654003045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654003046 putative active site [active] 82654003047 heme pocket [chemical binding]; other site 82654003048 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 82654003049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654003050 putative active site [active] 82654003051 heme pocket [chemical binding]; other site 82654003052 PAS domain S-box; Region: sensory_box; TIGR00229 82654003053 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654003054 putative active site [active] 82654003055 heme pocket [chemical binding]; other site 82654003056 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654003057 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654003058 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654003059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654003060 ATP binding site [chemical binding]; other site 82654003061 Mg2+ binding site [ion binding]; other site 82654003062 G-X-G motif; other site 82654003063 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 82654003064 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 82654003065 substrate binding pocket [chemical binding]; other site 82654003066 membrane-bound complex binding site; other site 82654003067 hinge residues; other site 82654003068 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 82654003069 anti sigma factor interaction site; other site 82654003070 regulatory phosphorylation site [posttranslational modification]; other site 82654003071 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 82654003072 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 82654003073 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 82654003074 glucosylglycerol-phosphate synthase; Region: gluc_glyc_Psyn; TIGR02398 82654003075 active site 82654003076 homotetramer interface [polypeptide binding]; other site 82654003077 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 82654003078 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 82654003079 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 82654003080 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 82654003081 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 82654003082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 82654003083 putative substrate translocation pore; other site 82654003084 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 82654003085 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 82654003086 N- and C-terminal domain interface [polypeptide binding]; other site 82654003087 active site 82654003088 MgATP binding site [chemical binding]; other site 82654003089 catalytic site [active] 82654003090 metal binding site [ion binding]; metal-binding site 82654003091 glycerol binding site [chemical binding]; other site 82654003092 homotetramer interface [polypeptide binding]; other site 82654003093 homodimer interface [polypeptide binding]; other site 82654003094 FBP binding site [chemical binding]; other site 82654003095 protein IIAGlc interface [polypeptide binding]; other site 82654003096 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 82654003097 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654003098 TPR motif; other site 82654003099 binding surface 82654003100 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654003101 TPR motif; other site 82654003102 binding surface 82654003103 Tetratricopeptide repeat; Region: TPR_12; pfam13424 82654003104 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 82654003105 TPR motif; other site 82654003106 DNA gyrase subunit A; Validated; Region: PRK05560 82654003107 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 82654003108 CAP-like domain; other site 82654003109 active site 82654003110 primary dimer interface [polypeptide binding]; other site 82654003111 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 82654003112 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 82654003113 Calx-beta domain; Region: Calx-beta; cl02522 82654003114 Calx-beta domain; Region: Calx-beta; cl02522 82654003115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 82654003116 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 82654003117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654003118 S-adenosylmethionine binding site [chemical binding]; other site 82654003119 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 82654003120 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 82654003121 Phycobilisome protein; Region: Phycobilisome; cl08227 82654003122 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 82654003123 V4R domain; Region: V4R; pfam02830 82654003124 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 82654003125 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 82654003126 catalytic loop [active] 82654003127 iron binding site [ion binding]; other site 82654003128 phospholipid-translocating P-type ATPase, flippase; Region: ATPase-Plipid; TIGR01652 82654003129 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 82654003130 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 82654003131 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 82654003132 PsaD; Region: PsaD; cl03639 82654003133 Response regulator receiver domain; Region: Response_reg; pfam00072 82654003134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654003135 active site 82654003136 phosphorylation site [posttranslational modification] 82654003137 intermolecular recognition site; other site 82654003138 dimerization interface [polypeptide binding]; other site 82654003139 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 82654003140 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 82654003141 Mg++ binding site [ion binding]; other site 82654003142 putative catalytic motif [active] 82654003143 substrate binding site [chemical binding]; other site 82654003144 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 82654003145 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 82654003146 dimer interface [polypeptide binding]; other site 82654003147 active site 82654003148 glycine-pyridoxal phosphate binding site [chemical binding]; other site 82654003149 folate binding site [chemical binding]; other site 82654003150 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654003151 putative active site [active] 82654003152 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 82654003153 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 82654003154 active site 82654003155 substrate binding site [chemical binding]; other site 82654003156 metal binding site [ion binding]; metal-binding site 82654003157 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 82654003158 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654003159 active site 82654003160 ATP binding site [chemical binding]; other site 82654003161 substrate binding site [chemical binding]; other site 82654003162 activation loop (A-loop); other site 82654003163 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654003164 TPR repeat; Region: TPR_11; pfam13414 82654003165 TPR motif; other site 82654003166 ribonuclease PH; Reviewed; Region: rph; PRK00173 82654003167 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 82654003168 oligomer interface [polypeptide binding]; other site 82654003169 RNA binding site [nucleotide binding]; other site 82654003170 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 82654003171 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 82654003172 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654003173 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654003174 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654003175 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654003176 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654003177 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 82654003178 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 82654003179 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 82654003180 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 82654003181 active site 82654003182 catalytic residues [active] 82654003183 DNA binding site [nucleotide binding] 82654003184 Int/Topo IB signature motif; other site 82654003185 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 82654003186 polymerase nucleotide-binding site; other site 82654003187 DNA-binding residues [nucleotide binding]; DNA binding site 82654003188 nucleotide binding site [chemical binding]; other site 82654003189 primase nucleotide-binding site [nucleotide binding]; other site 82654003190 Virulence-associated protein E; Region: VirE; pfam05272 82654003191 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 82654003192 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 82654003193 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 82654003194 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 82654003195 ATP binding site [chemical binding]; other site 82654003196 putative Mg++ binding site [ion binding]; other site 82654003197 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 82654003198 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 82654003199 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 82654003200 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 82654003201 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 82654003202 HsdM N-terminal domain; Region: HsdM_N; pfam12161 82654003203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 82654003204 Part of AAA domain; Region: AAA_19; pfam13245 82654003205 Family description; Region: UvrD_C_2; pfam13538 82654003206 Domain of unknown function (DUF955); Region: DUF955; pfam06114 82654003207 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 82654003208 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 82654003209 homopentamer interface [polypeptide binding]; other site 82654003210 active site 82654003211 photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576 82654003212 Late competence development protein ComFB; Region: ComFB; pfam10719 82654003213 Late competence development protein ComFB; Region: ComFB; pfam10719 82654003214 Phycobilisome protein; Region: Phycobilisome; cl08227 82654003215 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 82654003216 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 82654003217 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 82654003218 alpha subunit interaction interface [polypeptide binding]; other site 82654003219 Walker A motif; other site 82654003220 ATP binding site [chemical binding]; other site 82654003221 Walker B motif; other site 82654003222 inhibitor binding site; inhibition site 82654003223 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 82654003224 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK01474 82654003225 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 82654003226 gamma subunit interface [polypeptide binding]; other site 82654003227 epsilon subunit interface [polypeptide binding]; other site 82654003228 LBP interface [polypeptide binding]; other site 82654003229 dihydrodipicolinate reductase; Provisional; Region: PRK00048 82654003230 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 82654003231 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 82654003232 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 82654003233 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 82654003234 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 82654003235 catalytic residue [active] 82654003236 Proline dehydrogenase; Region: Pro_dh; pfam01619 82654003237 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 82654003238 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237 82654003239 Glutamate binding site [chemical binding]; other site 82654003240 homodimer interface [polypeptide binding]; other site 82654003241 NAD binding site [chemical binding]; other site 82654003242 catalytic residues [active] 82654003243 Uncharacterized conserved protein [Function unknown]; Region: COG3937 82654003244 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 82654003245 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 82654003246 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 82654003247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654003248 binding surface 82654003249 TPR repeat; Region: TPR_11; pfam13414 82654003250 TPR motif; other site 82654003251 TPR repeat; Region: TPR_11; pfam13414 82654003252 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654003253 binding surface 82654003254 TPR motif; other site 82654003255 TPR repeat; Region: TPR_11; pfam13414 82654003256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654003257 binding surface 82654003258 TPR motif; other site 82654003259 TPR repeat; Region: TPR_11; pfam13414 82654003260 Tetratricopeptide repeat; Region: TPR_16; pfam13432 82654003261 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 82654003262 TPR repeat; Region: TPR_11; pfam13414 82654003263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654003264 TPR motif; other site 82654003265 TPR repeat; Region: TPR_11; pfam13414 82654003266 binding surface 82654003267 TPR repeat; Region: TPR_11; pfam13414 82654003268 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654003269 binding surface 82654003270 TPR motif; other site 82654003271 TPR repeat; Region: TPR_11; pfam13414 82654003272 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654003273 binding surface 82654003274 TPR motif; other site 82654003275 TPR repeat; Region: TPR_11; pfam13414 82654003276 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 82654003277 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 82654003278 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654003279 5-oxoprolinase; Region: PLN02666 82654003280 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 82654003281 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 82654003282 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 82654003283 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 82654003284 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 82654003285 P-loop; other site 82654003286 Magnesium ion binding site [ion binding]; other site 82654003287 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 82654003288 Magnesium ion binding site [ion binding]; other site 82654003289 CsbD-like; Region: CsbD; pfam05532 82654003290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 82654003291 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 82654003292 ATP-grasp domain; Region: ATP-grasp_4; cl17255 82654003293 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 82654003294 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 82654003295 Pirin-related protein [General function prediction only]; Region: COG1741 82654003296 Pirin; Region: Pirin; pfam02678 82654003297 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 82654003298 Coenzyme A binding pocket [chemical binding]; other site 82654003299 Sterol carrier protein domain; Region: SCP2_2; pfam13530 82654003300 Homeodomain-like domain; Region: HTH_23; pfam13384 82654003301 Winged helix-turn helix; Region: HTH_29; pfam13551 82654003302 Winged helix-turn helix; Region: HTH_33; pfam13592 82654003303 DDE superfamily endonuclease; Region: DDE_3; pfam13358 82654003304 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 82654003305 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 82654003306 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 82654003307 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 82654003308 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 82654003309 PsbL protein; Region: PsbL; cl03581 82654003310 photosystem II reaction center protein J; Provisional; Region: PRK02565 82654003311 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654003312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 82654003313 active site 82654003314 phosphorylation site [posttranslational modification] 82654003315 intermolecular recognition site; other site 82654003316 dimerization interface [polypeptide binding]; other site 82654003317 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 82654003318 putative binding surface; other site 82654003319 active site 82654003320 Response regulator receiver domain; Region: Response_reg; pfam00072 82654003321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654003322 active site 82654003323 phosphorylation site [posttranslational modification] 82654003324 intermolecular recognition site; other site 82654003325 dimerization interface [polypeptide binding]; other site 82654003326 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654003327 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654003328 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654003329 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654003330 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654003331 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654003332 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654003333 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654003334 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654003335 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654003336 Ion channel; Region: Ion_trans_2; pfam07885 82654003337 TrkA-N domain; Region: TrkA_N; pfam02254 82654003338 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 82654003339 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 82654003340 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 82654003341 multimerization interface [polypeptide binding]; other site 82654003342 RbcX protein; Region: RcbX; pfam02341 82654003343 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 82654003344 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 82654003345 homodimer interface [polypeptide binding]; other site 82654003346 active site 82654003347 heterodimer interface [polypeptide binding]; other site 82654003348 catalytic residue [active] 82654003349 metal binding site [ion binding]; metal-binding site 82654003350 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 82654003351 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 82654003352 Walker A/P-loop; other site 82654003353 ATP binding site [chemical binding]; other site 82654003354 Q-loop/lid; other site 82654003355 ABC transporter signature motif; other site 82654003356 Walker B; other site 82654003357 D-loop; other site 82654003358 H-loop/switch region; other site 82654003359 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 82654003360 TPR motif; other site 82654003361 binding surface 82654003362 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 82654003363 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 82654003364 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 82654003365 dimer interface [polypeptide binding]; other site 82654003366 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 82654003367 active site 82654003368 Fe binding site [ion binding]; other site 82654003369 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 82654003370 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 82654003371 active site 82654003372 motif I; other site 82654003373 motif II; other site 82654003374 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 82654003375 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 82654003376 SLBB domain; Region: SLBB; pfam10531 82654003377 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 82654003378 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 82654003379 NAD binding site [chemical binding]; other site 82654003380 putative substrate binding site 2 [chemical binding]; other site 82654003381 putative substrate binding site 1 [chemical binding]; other site 82654003382 active site 82654003383 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 82654003384 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 82654003385 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 82654003386 Ycf46; Provisional; Region: ycf46; CHL00195 82654003387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654003388 Walker A motif; other site 82654003389 ATP binding site [chemical binding]; other site 82654003390 Walker B motif; other site 82654003391 arginine finger; other site 82654003392 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 82654003393 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 82654003394 active site 82654003395 NTP binding site [chemical binding]; other site 82654003396 metal binding triad [ion binding]; metal-binding site 82654003397 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 82654003398 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 82654003399 methionine sulfoxide reductase B; Provisional; Region: PRK00222 82654003400 SelR domain; Region: SelR; pfam01641 82654003401 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 82654003402 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 82654003403 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 82654003404 catalytic residue [active] 82654003405 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 82654003406 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 82654003407 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 82654003408 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 82654003409 substrate binding site [chemical binding]; other site 82654003410 oxyanion hole (OAH) forming residues; other site 82654003411 trimer interface [polypeptide binding]; other site 82654003412 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 82654003413 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 82654003414 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 82654003415 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 82654003416 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 82654003417 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 82654003418 G1 box; other site 82654003419 Walker A motif; other site 82654003420 GTP/Mg2+ binding site [chemical binding]; other site 82654003421 Switch I region; other site 82654003422 G2 box; other site 82654003423 Switch II region; other site 82654003424 G3 box; other site 82654003425 G4 box; other site 82654003426 G5 box; other site 82654003427 Domain of unknown function (DUF697); Region: DUF697; pfam05128 82654003428 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 82654003429 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 82654003430 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 82654003431 homotetramer interface [polypeptide binding]; other site 82654003432 ligand binding site [chemical binding]; other site 82654003433 catalytic site [active] 82654003434 NAD binding site [chemical binding]; other site 82654003435 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 82654003436 Y-family of DNA polymerases; Region: PolY; cl12025 82654003437 active site 82654003438 DNA binding site [nucleotide binding] 82654003439 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 82654003440 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 82654003441 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 82654003442 Catalytic site [active] 82654003443 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 82654003444 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 82654003445 DNA binding residues [nucleotide binding] 82654003446 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 82654003447 dimer interface [polypeptide binding]; other site 82654003448 metal binding site [ion binding]; metal-binding site 82654003449 geranylgeranyl reductase; Region: ChlP; TIGR02028 82654003450 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 82654003451 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 82654003452 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 82654003453 active site 82654003454 catalytic site [active] 82654003455 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 82654003456 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 82654003457 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 82654003458 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 82654003459 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 82654003460 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 82654003461 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 82654003462 Surface antigen; Region: Bac_surface_Ag; pfam01103 82654003463 Peptidase family M48; Region: Peptidase_M48; pfam01435 82654003464 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 82654003465 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 82654003466 active site 82654003467 motif I; other site 82654003468 motif II; other site 82654003469 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 82654003470 catalytic motif [active] 82654003471 Catalytic residue [active] 82654003472 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654003473 putative active site [active] 82654003474 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 82654003475 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 82654003476 HIGH motif; other site 82654003477 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 82654003478 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 82654003479 active site 82654003480 KMSKS motif; other site 82654003481 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 82654003482 tRNA binding surface [nucleotide binding]; other site 82654003483 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 82654003484 DRTGG domain; Region: DRTGG; pfam07085 82654003485 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 82654003486 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 82654003487 active site 82654003488 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 82654003489 30S subunit binding site; other site 82654003490 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 82654003491 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 82654003492 active site 82654003493 dimer interface [polypeptide binding]; other site 82654003494 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 82654003495 dimer interface [polypeptide binding]; other site 82654003496 active site 82654003497 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 82654003498 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 82654003499 active site 82654003500 catalytic tetrad [active] 82654003501 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 82654003502 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 82654003503 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 82654003504 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 82654003505 Walker A/P-loop; other site 82654003506 ATP binding site [chemical binding]; other site 82654003507 Q-loop/lid; other site 82654003508 ABC transporter signature motif; other site 82654003509 Walker B; other site 82654003510 D-loop; other site 82654003511 H-loop/switch region; other site 82654003512 trigger factor; Provisional; Region: tig; PRK01490 82654003513 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 82654003514 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 82654003515 Clp protease; Region: CLP_protease; pfam00574 82654003516 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 82654003517 oligomer interface [polypeptide binding]; other site 82654003518 active site residues [active] 82654003519 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 82654003520 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 82654003521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654003522 Walker A motif; other site 82654003523 ATP binding site [chemical binding]; other site 82654003524 Walker B motif; other site 82654003525 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 82654003526 YacP-like NYN domain; Region: NYN_YacP; pfam05991 82654003527 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 82654003528 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 82654003529 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 82654003530 putative dimer interface [polypeptide binding]; other site 82654003531 N-terminal domain interface [polypeptide binding]; other site 82654003532 putative substrate binding pocket (H-site) [chemical binding]; other site 82654003533 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 82654003534 putative active site [active] 82654003535 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 82654003536 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 82654003537 metal-binding site [ion binding] 82654003538 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 82654003539 Soluble P-type ATPase [General function prediction only]; Region: COG4087 82654003540 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 82654003541 metal-binding site [ion binding] 82654003542 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 82654003543 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 82654003544 putative valine binding site [chemical binding]; other site 82654003545 dimer interface [polypeptide binding]; other site 82654003546 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 82654003547 HEAT repeats; Region: HEAT_2; pfam13646 82654003548 HEAT repeats; Region: HEAT_2; pfam13646 82654003549 HEAT repeats; Region: HEAT_2; pfam13646 82654003550 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 82654003551 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 82654003552 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 82654003553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654003554 Methyltransferase domain; Region: Methyltransf_23; pfam13489 82654003555 S-adenosylmethionine binding site [chemical binding]; other site 82654003556 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 82654003557 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 82654003558 domain interfaces; other site 82654003559 active site 82654003560 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 82654003561 Glutaminase; Region: Glutaminase; cl00907 82654003562 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 82654003563 putative binding surface; other site 82654003564 active site 82654003565 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 82654003566 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 82654003567 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 82654003568 Caspase domain; Region: Peptidase_C14; pfam00656 82654003569 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 82654003570 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 82654003571 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 82654003572 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 82654003573 phosphopeptide binding site; other site 82654003574 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 82654003575 Transglycosylase; Region: Transgly; pfam00912 82654003576 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 82654003577 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 82654003578 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 82654003579 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 82654003580 substrate binding pocket [chemical binding]; other site 82654003581 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 82654003582 B12 binding site [chemical binding]; other site 82654003583 cobalt ligand [ion binding]; other site 82654003584 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 82654003585 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 82654003586 Fasciclin domain; Region: Fasciclin; pfam02469 82654003587 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 82654003588 amphipathic channel; other site 82654003589 Asn-Pro-Ala signature motifs; other site 82654003590 Photosystem II reaction centre M protein (PsbM); Region: PsbM; cl11459 82654003591 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 82654003592 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 82654003593 active site 82654003594 catalytic site [active] 82654003595 substrate binding site [chemical binding]; other site 82654003596 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 82654003597 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 82654003598 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 82654003599 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 82654003600 homodimer interface [polypeptide binding]; other site 82654003601 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 82654003602 active site pocket [active] 82654003603 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 82654003604 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 82654003605 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 82654003606 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 82654003607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654003608 dimer interface [polypeptide binding]; other site 82654003609 conserved gate region; other site 82654003610 putative PBP binding loops; other site 82654003611 ABC-ATPase subunit interface; other site 82654003612 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 82654003613 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 82654003614 purine monophosphate binding site [chemical binding]; other site 82654003615 dimer interface [polypeptide binding]; other site 82654003616 putative catalytic residues [active] 82654003617 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 82654003618 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 82654003619 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 82654003620 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 82654003621 domain interfaces; other site 82654003622 active site 82654003623 Predicted methyltransferases [General function prediction only]; Region: COG0313 82654003624 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 82654003625 putative SAM binding site [chemical binding]; other site 82654003626 putative homodimer interface [polypeptide binding]; other site 82654003627 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 82654003628 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 82654003629 Ribosomal RNA methyltransferase (FmrO); Region: FmrO; pfam07091 82654003630 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 82654003631 Ribosomal RNA methyltransferase (FmrO); Region: FmrO; pfam07091 82654003632 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 82654003633 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 82654003634 S-adenosylmethionine synthetase; Validated; Region: PRK05250 82654003635 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 82654003636 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 82654003637 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 82654003638 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 82654003639 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 82654003640 ligand binding site [chemical binding]; other site 82654003641 flexible hinge region; other site 82654003642 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 82654003643 putative switch regulator; other site 82654003644 non-specific DNA interactions [nucleotide binding]; other site 82654003645 DNA binding site [nucleotide binding] 82654003646 sequence specific DNA binding site [nucleotide binding]; other site 82654003647 putative cAMP binding site [chemical binding]; other site 82654003648 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 82654003649 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 82654003650 active site 82654003651 nucleophile elbow; other site 82654003652 YcxB-like protein; Region: YcxB; pfam14317 82654003653 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 82654003654 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 82654003655 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 82654003656 Aspartase; Region: Aspartase; cd01357 82654003657 active sites [active] 82654003658 tetramer interface [polypeptide binding]; other site 82654003659 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 82654003660 putative homodimer interface [polypeptide binding]; other site 82654003661 putative active site pocket [active] 82654003662 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 82654003663 MoxR-like ATPases [General function prediction only]; Region: COG0714 82654003664 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 82654003665 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 82654003666 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 82654003667 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 82654003668 catalytic residue [active] 82654003669 putative FPP diphosphate binding site; other site 82654003670 putative FPP binding hydrophobic cleft; other site 82654003671 dimer interface [polypeptide binding]; other site 82654003672 putative IPP diphosphate binding site; other site 82654003673 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 82654003674 dinuclear metal binding motif [ion binding]; other site 82654003675 AAA ATPase domain; Region: AAA_16; pfam13191 82654003676 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 82654003677 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654003678 binding surface 82654003679 TPR motif; other site 82654003680 Tetratricopeptide repeat; Region: TPR_12; pfam13424 82654003681 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 82654003682 Uncharacterized conserved protein [Function unknown]; Region: COG0398 82654003683 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 82654003684 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 82654003685 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 82654003686 ligand binding site [chemical binding]; other site 82654003687 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 82654003688 RuvA N terminal domain; Region: RuvA_N; pfam01330 82654003689 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 82654003690 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 82654003691 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 82654003692 ATP-NAD kinase; Region: NAD_kinase; pfam01513 82654003693 HEAT repeats; Region: HEAT_2; pfam13646 82654003694 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 82654003695 active site 82654003696 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 82654003697 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 82654003698 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 82654003699 ATP binding site [chemical binding]; other site 82654003700 active site 82654003701 substrate binding site [chemical binding]; other site 82654003702 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 82654003703 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 82654003704 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 82654003705 Surface antigen; Region: Bac_surface_Ag; pfam01103 82654003706 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_6; cd06256 82654003707 putative active site [active] 82654003708 Zn binding site [ion binding]; other site 82654003709 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 82654003710 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 82654003711 Late competence development protein ComFB; Region: ComFB; pfam10719 82654003712 Late competence development protein ComFB; Region: ComFB; pfam10719 82654003713 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 82654003714 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 82654003715 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 82654003716 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 82654003717 active site 82654003718 cell division protein FtsZ; Validated; Region: PRK09330 82654003719 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 82654003720 nucleotide binding site [chemical binding]; other site 82654003721 SulA interaction site; other site 82654003722 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 82654003723 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 82654003724 Methyltransferase domain; Region: Methyltransf_31; pfam13847 82654003725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654003726 S-adenosylmethionine binding site [chemical binding]; other site 82654003727 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 82654003728 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 82654003729 metal binding site [ion binding]; metal-binding site 82654003730 dimer interface [polypeptide binding]; other site 82654003731 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 82654003732 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 82654003733 active site 82654003734 substrate binding site [chemical binding]; other site 82654003735 metal binding site [ion binding]; metal-binding site 82654003736 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 82654003737 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 82654003738 putative active site [active] 82654003739 chromosome segregation protein; Provisional; Region: PRK01156 82654003740 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654003741 Walker A/P-loop; other site 82654003742 ATP binding site [chemical binding]; other site 82654003743 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654003744 Q-loop/lid; other site 82654003745 ABC transporter signature motif; other site 82654003746 Walker B; other site 82654003747 D-loop; other site 82654003748 H-loop/switch region; other site 82654003749 TPR repeat; Region: TPR_11; pfam13414 82654003750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654003751 binding surface 82654003752 TPR motif; other site 82654003753 TPR repeat; Region: TPR_11; pfam13414 82654003754 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 82654003755 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 82654003756 ribosomal protein L23; Region: rpl23; CHL00030 82654003757 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 82654003758 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 82654003759 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 82654003760 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 82654003761 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 82654003762 putative translocon binding site; other site 82654003763 protein-rRNA interface [nucleotide binding]; other site 82654003764 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 82654003765 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 82654003766 G-X-X-G motif; other site 82654003767 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 82654003768 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 82654003769 23S rRNA interface [nucleotide binding]; other site 82654003770 5S rRNA interface [nucleotide binding]; other site 82654003771 putative antibiotic binding site [chemical binding]; other site 82654003772 L25 interface [polypeptide binding]; other site 82654003773 L27 interface [polypeptide binding]; other site 82654003774 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 82654003775 23S rRNA interface [nucleotide binding]; other site 82654003776 putative translocon interaction site; other site 82654003777 signal recognition particle (SRP54) interaction site; other site 82654003778 L23 interface [polypeptide binding]; other site 82654003779 trigger factor interaction site; other site 82654003780 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 82654003781 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 82654003782 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 82654003783 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 82654003784 RNA binding site [nucleotide binding]; other site 82654003785 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 82654003786 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 82654003787 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 82654003788 ribosomal protein S8; Region: rps8; CHL00042 82654003789 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 82654003790 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 82654003791 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 82654003792 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 82654003793 23S rRNA interface [nucleotide binding]; other site 82654003794 L21e interface [polypeptide binding]; other site 82654003795 5S rRNA interface [nucleotide binding]; other site 82654003796 L27 interface [polypeptide binding]; other site 82654003797 L5 interface [polypeptide binding]; other site 82654003798 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 82654003799 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 82654003800 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 82654003801 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 82654003802 SecY translocase; Region: SecY; pfam00344 82654003803 adenylate kinase; Reviewed; Region: adk; PRK00279 82654003804 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 82654003805 AMP-binding site [chemical binding]; other site 82654003806 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 82654003807 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 82654003808 rRNA binding site [nucleotide binding]; other site 82654003809 predicted 30S ribosome binding site; other site 82654003810 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 82654003811 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 82654003812 active site 82654003813 metal binding site [ion binding]; metal-binding site 82654003814 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 82654003815 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 82654003816 Peptidase family M23; Region: Peptidase_M23; pfam01551 82654003817 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 82654003818 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 82654003819 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 82654003820 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 82654003821 putative active site [active] 82654003822 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 82654003823 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 82654003824 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 82654003825 dimerization interface [polypeptide binding]; other site 82654003826 active site 82654003827 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 82654003828 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 82654003829 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 82654003830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 82654003831 homodimer interface [polypeptide binding]; other site 82654003832 catalytic residue [active] 82654003833 Transglycosylase; Region: Transgly; pfam00912 82654003834 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 82654003835 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 82654003836 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 82654003837 Methyltransferase domain; Region: Methyltransf_23; pfam13489 82654003838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654003839 S-adenosylmethionine binding site [chemical binding]; other site 82654003840 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 82654003841 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654003842 binding surface 82654003843 TPR motif; other site 82654003844 Tetratricopeptide repeat; Region: TPR_9; pfam13371 82654003845 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 82654003846 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 82654003847 TPR repeat; Region: TPR_11; pfam13414 82654003848 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654003849 binding surface 82654003850 TPR repeat; Region: TPR_11; pfam13414 82654003851 TPR motif; other site 82654003852 TPR repeat; Region: TPR_11; pfam13414 82654003853 TPR repeat; Region: TPR_11; pfam13414 82654003854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654003855 binding surface 82654003856 TPR motif; other site 82654003857 TPR repeat; Region: TPR_11; pfam13414 82654003858 TPR repeat; Region: TPR_11; pfam13414 82654003859 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654003860 binding surface 82654003861 TPR motif; other site 82654003862 TPR repeat; Region: TPR_11; pfam13414 82654003863 TPR repeat; Region: TPR_11; pfam13414 82654003864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654003865 binding surface 82654003866 TPR motif; other site 82654003867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654003868 binding surface 82654003869 TPR motif; other site 82654003870 Tetratricopeptide repeat; Region: TPR_12; pfam13424 82654003871 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 82654003872 tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887 82654003873 UbiA prenyltransferase family; Region: UbiA; pfam01040 82654003874 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 82654003875 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 82654003876 Walker A/P-loop; other site 82654003877 ATP binding site [chemical binding]; other site 82654003878 Q-loop/lid; other site 82654003879 ABC transporter signature motif; other site 82654003880 Walker B; other site 82654003881 D-loop; other site 82654003882 H-loop/switch region; other site 82654003883 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 82654003884 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 82654003885 active site 82654003886 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 82654003887 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 82654003888 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 82654003889 FAD binding domain; Region: FAD_binding_4; pfam01565 82654003890 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 82654003891 colanic acid biosynthesis acetyltransferase WcaB; Region: WcaB; TIGR04016 82654003892 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 82654003893 trimer interface [polypeptide binding]; other site 82654003894 active site 82654003895 substrate binding site [chemical binding]; other site 82654003896 CoA binding site [chemical binding]; other site 82654003897 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 82654003898 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 82654003899 hinge; other site 82654003900 active site 82654003901 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 82654003902 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 82654003903 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 82654003904 NAD(P) binding site [chemical binding]; other site 82654003905 homodimer interface [polypeptide binding]; other site 82654003906 substrate binding site [chemical binding]; other site 82654003907 active site 82654003908 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 82654003909 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 82654003910 substrate binding site [chemical binding]; other site 82654003911 hexamer interface [polypeptide binding]; other site 82654003912 metal binding site [ion binding]; metal-binding site 82654003913 V-type ATP synthase subunit B; Provisional; Region: PRK02118 82654003914 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 82654003915 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 82654003916 Walker A motif homologous position; other site 82654003917 Walker B motif; other site 82654003918 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 82654003919 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 82654003920 cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153 82654003921 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 82654003922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 82654003923 putative glycosyl transferase; Provisional; Region: PRK10307 82654003924 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 82654003925 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 82654003926 Chain length determinant protein; Region: Wzz; cl15801 82654003927 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 82654003928 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 82654003929 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 82654003930 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 82654003931 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 82654003932 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 82654003933 putative active site [active] 82654003934 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 82654003935 ketol-acid reductoisomerase; Provisional; Region: PRK05479 82654003936 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 82654003937 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 82654003938 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 82654003939 nudix motif; other site 82654003940 EVE domain; Region: EVE; pfam01878 82654003941 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 82654003942 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 82654003943 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 82654003944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654003945 dimer interface [polypeptide binding]; other site 82654003946 conserved gate region; other site 82654003947 putative PBP binding loops; other site 82654003948 ABC-ATPase subunit interface; other site 82654003949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654003950 dimer interface [polypeptide binding]; other site 82654003951 conserved gate region; other site 82654003952 putative PBP binding loops; other site 82654003953 ABC-ATPase subunit interface; other site 82654003954 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654003955 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654003956 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654003957 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654003958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 82654003959 Coenzyme A binding pocket [chemical binding]; other site 82654003960 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 82654003961 FecR protein; Region: FecR; pfam04773 82654003962 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 82654003963 active site 82654003964 intersubunit interface [polypeptide binding]; other site 82654003965 catalytic residue [active] 82654003966 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 82654003967 putative binding surface; other site 82654003968 active site 82654003969 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 82654003970 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 82654003971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654003972 ATP binding site [chemical binding]; other site 82654003973 Mg2+ binding site [ion binding]; other site 82654003974 G-X-G motif; other site 82654003975 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 82654003976 Response regulator receiver domain; Region: Response_reg; pfam00072 82654003977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654003978 active site 82654003979 phosphorylation site [posttranslational modification] 82654003980 intermolecular recognition site; other site 82654003981 dimerization interface [polypeptide binding]; other site 82654003982 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654003983 Tetratricopeptide repeat; Region: TPR_16; pfam13432 82654003984 binding surface 82654003985 TPR motif; other site 82654003986 HAMP domain; Region: HAMP; pfam00672 82654003987 dimerization interface [polypeptide binding]; other site 82654003988 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 82654003989 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 82654003990 dimer interface [polypeptide binding]; other site 82654003991 putative CheW interface [polypeptide binding]; other site 82654003992 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 82654003993 Response regulator receiver domain; Region: Response_reg; pfam00072 82654003994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654003995 active site 82654003996 phosphorylation site [posttranslational modification] 82654003997 intermolecular recognition site; other site 82654003998 dimerization interface [polypeptide binding]; other site 82654003999 Response regulator receiver domain; Region: Response_reg; pfam00072 82654004000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654004001 active site 82654004002 phosphorylation site [posttranslational modification] 82654004003 intermolecular recognition site; other site 82654004004 dimerization interface [polypeptide binding]; other site 82654004005 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 82654004006 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654004007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654004008 active site 82654004009 phosphorylation site [posttranslational modification] 82654004010 intermolecular recognition site; other site 82654004011 dimerization interface [polypeptide binding]; other site 82654004012 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 82654004013 RNA/DNA hybrid binding site [nucleotide binding]; other site 82654004014 active site 82654004015 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 82654004016 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 82654004017 catalytic residues [active] 82654004018 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 82654004019 CHASE2 domain; Region: CHASE2; pfam05226 82654004020 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 82654004021 cyclase homology domain; Region: CHD; cd07302 82654004022 nucleotidyl binding site; other site 82654004023 metal binding site [ion binding]; metal-binding site 82654004024 dimer interface [polypeptide binding]; other site 82654004025 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 82654004026 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 82654004027 putative metal binding site; other site 82654004028 Tetratricopeptide repeat; Region: TPR_12; pfam13424 82654004029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654004030 binding surface 82654004031 TPR repeat; Region: TPR_11; pfam13414 82654004032 TPR motif; other site 82654004033 TPR repeat; Region: TPR_11; pfam13414 82654004034 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 82654004035 ABC1 family; Region: ABC1; pfam03109 82654004036 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 82654004037 active site 82654004038 ATP binding site [chemical binding]; other site 82654004039 MgtC family; Region: MgtC; pfam02308 82654004040 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 82654004041 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 82654004042 Integral membrane protein TerC family; Region: TerC; cl10468 82654004043 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 82654004044 lipoyl attachment site [posttranslational modification]; other site 82654004045 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 82654004046 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 82654004047 phosphopeptide binding site; other site 82654004048 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 82654004049 cyclase homology domain; Region: CHD; cd07302 82654004050 nucleotidyl binding site; other site 82654004051 metal binding site [ion binding]; metal-binding site 82654004052 dimer interface [polypeptide binding]; other site 82654004053 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 82654004054 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 82654004055 phosphopeptide binding site; other site 82654004056 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 82654004057 cyclase homology domain; Region: CHD; cd07302 82654004058 nucleotidyl binding site; other site 82654004059 metal binding site [ion binding]; metal-binding site 82654004060 dimer interface [polypeptide binding]; other site 82654004061 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 82654004062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 82654004063 conserved hypothetical protein; Region: TIGR03492 82654004064 Predicted ATPase [General function prediction only]; Region: COG4637 82654004065 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654004066 Walker A/P-loop; other site 82654004067 ATP binding site [chemical binding]; other site 82654004068 Domain of unknown function DUF29; Region: DUF29; pfam01724 82654004069 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 82654004070 tetramer (dimer of dimers) interface [polypeptide binding]; other site 82654004071 active site 82654004072 dimer interface [polypeptide binding]; other site 82654004073 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 82654004074 Uncharacterized conserved protein [Function unknown]; Region: COG0393 82654004075 Peptidase family M48; Region: Peptidase_M48; cl12018 82654004076 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 82654004077 S17 interaction site [polypeptide binding]; other site 82654004078 S8 interaction site; other site 82654004079 16S rRNA interaction site [nucleotide binding]; other site 82654004080 streptomycin interaction site [chemical binding]; other site 82654004081 23S rRNA interaction site [nucleotide binding]; other site 82654004082 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 82654004083 30S ribosomal protein S7; Validated; Region: PRK05302 82654004084 elongation factor G; Reviewed; Region: PRK00007 82654004085 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 82654004086 G1 box; other site 82654004087 putative GEF interaction site [polypeptide binding]; other site 82654004088 GTP/Mg2+ binding site [chemical binding]; other site 82654004089 Switch I region; other site 82654004090 G2 box; other site 82654004091 G3 box; other site 82654004092 Switch II region; other site 82654004093 G4 box; other site 82654004094 G5 box; other site 82654004095 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 82654004096 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 82654004097 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 82654004098 elongation factor Tu; Region: tufA; CHL00071 82654004099 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 82654004100 G1 box; other site 82654004101 GEF interaction site [polypeptide binding]; other site 82654004102 GTP/Mg2+ binding site [chemical binding]; other site 82654004103 Switch I region; other site 82654004104 G2 box; other site 82654004105 G3 box; other site 82654004106 Switch II region; other site 82654004107 G4 box; other site 82654004108 G5 box; other site 82654004109 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 82654004110 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 82654004111 Antibiotic Binding Site [chemical binding]; other site 82654004112 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 82654004113 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 82654004114 active site 82654004115 SAM binding site [chemical binding]; other site 82654004116 homodimer interface [polypeptide binding]; other site 82654004117 TPR repeat; Region: TPR_11; pfam13414 82654004118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 82654004119 TPR repeat; Region: TPR_11; pfam13414 82654004120 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654004121 binding surface 82654004122 TPR motif; other site 82654004123 TPR repeat; Region: TPR_11; pfam13414 82654004124 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654004125 binding surface 82654004126 TPR motif; other site 82654004127 TPR repeat; Region: TPR_11; pfam13414 82654004128 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 82654004129 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 82654004130 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 82654004131 homoserine dehydrogenase; Provisional; Region: PRK06349 82654004132 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 82654004133 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 82654004134 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 82654004135 Methyltransferase domain; Region: Methyltransf_18; pfam12847 82654004136 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654004137 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 82654004138 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 82654004139 dimer interface [polypeptide binding]; other site 82654004140 substrate binding site [chemical binding]; other site 82654004141 catalytic triad [active] 82654004142 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 82654004143 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 82654004144 active site 82654004145 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 82654004146 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 82654004147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654004148 Walker A/P-loop; other site 82654004149 ATP binding site [chemical binding]; other site 82654004150 Q-loop/lid; other site 82654004151 ABC transporter signature motif; other site 82654004152 Walker B; other site 82654004153 D-loop; other site 82654004154 H-loop/switch region; other site 82654004155 Domain of unknown function DUF21; Region: DUF21; pfam01595 82654004156 FOG: CBS domain [General function prediction only]; Region: COG0517 82654004157 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 82654004158 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 82654004159 Rrf2 family protein; Region: rrf2_super; TIGR00738 82654004160 Transcriptional regulator; Region: Rrf2; cl17282 82654004161 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 82654004162 FecR protein; Region: FecR; pfam04773 82654004163 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 82654004164 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 82654004165 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 82654004166 replicative DNA helicase; Region: DnaB; TIGR00665 82654004167 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 82654004168 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 82654004169 Walker A motif; other site 82654004170 ATP binding site [chemical binding]; other site 82654004171 Walker B motif; other site 82654004172 DNA binding loops [nucleotide binding] 82654004173 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 82654004174 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 82654004175 Late competence development protein ComFB; Region: ComFB; pfam10719 82654004176 Late competence development protein ComFB; Region: ComFB; pfam10719 82654004177 NACHT domain; Region: NACHT; pfam05729 82654004178 threonine synthase; Validated; Region: PRK07591 82654004179 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 82654004180 homodimer interface [polypeptide binding]; other site 82654004181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 82654004182 catalytic residue [active] 82654004183 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 82654004184 Methyltransferase domain; Region: Methyltransf_25; pfam13649 82654004185 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 82654004186 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 82654004187 UbiA prenyltransferase family; Region: UbiA; pfam01040 82654004188 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 82654004189 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 82654004190 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 82654004191 EamA-like transporter family; Region: EamA; pfam00892 82654004192 EamA-like transporter family; Region: EamA; pfam00892 82654004193 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 82654004194 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 82654004195 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 82654004196 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 82654004197 active site 82654004198 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 82654004199 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 82654004200 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 82654004201 TrkA-N domain; Region: TrkA_N; pfam02254 82654004202 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 82654004203 TrkA-N domain; Region: TrkA_N; pfam02254 82654004204 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 82654004205 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 82654004206 alpha subunit interface [polypeptide binding]; other site 82654004207 TPP binding site [chemical binding]; other site 82654004208 heterodimer interface [polypeptide binding]; other site 82654004209 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 82654004210 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 82654004211 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 82654004212 active site 82654004213 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 82654004214 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 82654004215 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 82654004216 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 82654004217 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 82654004218 catalytic residues [active] 82654004219 O-Antigen ligase; Region: Wzy_C; cl04850 82654004220 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 82654004221 O-Antigen ligase; Region: Wzy_C; cl04850 82654004222 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 82654004223 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 82654004224 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 82654004225 DNA binding residues [nucleotide binding] 82654004226 Putative zinc-finger; Region: zf-HC2; pfam13490 82654004227 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 82654004228 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 82654004229 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 82654004230 protein binding site [polypeptide binding]; other site 82654004231 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 82654004232 haemagglutination activity domain; Region: Haemagg_act; pfam05860 82654004233 CHAT domain; Region: CHAT; cl17868 82654004234 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654004235 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654004236 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654004237 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654004238 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654004239 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654004240 dimer interface [polypeptide binding]; other site 82654004241 phosphorylation site [posttranslational modification] 82654004242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654004243 ATP binding site [chemical binding]; other site 82654004244 Mg2+ binding site [ion binding]; other site 82654004245 G-X-G motif; other site 82654004246 pseudaminic acid synthase; Region: PseI; TIGR03586 82654004247 NeuB family; Region: NeuB; pfam03102 82654004248 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 82654004249 NeuB binding interface [polypeptide binding]; other site 82654004250 putative substrate binding site [chemical binding]; other site 82654004251 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 82654004252 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 82654004253 Walker A/P-loop; other site 82654004254 ATP binding site [chemical binding]; other site 82654004255 Q-loop/lid; other site 82654004256 ABC transporter signature motif; other site 82654004257 Walker B; other site 82654004258 D-loop; other site 82654004259 H-loop/switch region; other site 82654004260 mce related protein; Region: MCE; pfam02470 82654004261 FOG: WD40 repeat [General function prediction only]; Region: COG2319 82654004262 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 82654004263 structural tetrad; other site 82654004264 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 82654004265 putative binding surface; other site 82654004266 active site 82654004267 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 82654004268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654004269 ATP binding site [chemical binding]; other site 82654004270 G-X-G motif; other site 82654004271 CheW-like domain; Region: CheW; pfam01584 82654004272 Response regulator receiver domain; Region: Response_reg; pfam00072 82654004273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654004274 active site 82654004275 phosphorylation site [posttranslational modification] 82654004276 intermolecular recognition site; other site 82654004277 dimerization interface [polypeptide binding]; other site 82654004278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654004279 TPR repeat; Region: TPR_11; pfam13414 82654004280 binding surface 82654004281 TPR motif; other site 82654004282 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 82654004283 dimerization interface [polypeptide binding]; other site 82654004284 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 82654004285 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 82654004286 dimer interface [polypeptide binding]; other site 82654004287 putative CheW interface [polypeptide binding]; other site 82654004288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 82654004289 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 82654004290 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 82654004291 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 82654004292 SnoaL-like domain; Region: SnoaL_4; cl17707 82654004293 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 82654004294 Coenzyme A binding pocket [chemical binding]; other site 82654004295 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 82654004296 FAD binding domain; Region: FAD_binding_4; pfam01565 82654004297 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 82654004298 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 82654004299 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 82654004300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654004301 S-adenosylmethionine binding site [chemical binding]; other site 82654004302 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 82654004303 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 82654004304 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 82654004305 Transcriptional regulators [Transcription]; Region: MarR; COG1846 82654004306 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 82654004307 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 82654004308 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 82654004309 Coenzyme A binding pocket [chemical binding]; other site 82654004310 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 82654004311 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 82654004312 dimerization interface [polypeptide binding]; other site 82654004313 ATP binding site [chemical binding]; other site 82654004314 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 82654004315 dimerization interface [polypeptide binding]; other site 82654004316 ATP binding site [chemical binding]; other site 82654004317 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 82654004318 putative active site [active] 82654004319 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 82654004320 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 82654004321 trmE is a tRNA modification GTPase; Region: trmE; cd04164 82654004322 G1 box; other site 82654004323 GTP/Mg2+ binding site [chemical binding]; other site 82654004324 Switch I region; other site 82654004325 G2 box; other site 82654004326 Switch II region; other site 82654004327 G3 box; other site 82654004328 G4 box; other site 82654004329 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 82654004330 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 82654004331 Photosystem II Pbs27; Region: PSII_Pbs27; cl11841 82654004332 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 82654004333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 82654004334 Transcriptional regulator [Transcription]; Region: LysR; COG0583 82654004335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 82654004336 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 82654004337 dimerization interface [polypeptide binding]; other site 82654004338 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 82654004339 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 82654004340 active site 82654004341 metal binding site [ion binding]; metal-binding site 82654004342 Protein of function (DUF2518); Region: DUF2518; pfam10726 82654004343 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 82654004344 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654004345 active site 82654004346 ATP binding site [chemical binding]; other site 82654004347 substrate binding site [chemical binding]; other site 82654004348 activation loop (A-loop); other site 82654004349 AAA ATPase domain; Region: AAA_16; pfam13191 82654004350 Predicted ATPase [General function prediction only]; Region: COG3899 82654004351 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654004352 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654004353 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 82654004354 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 82654004355 metal binding site [ion binding]; metal-binding site 82654004356 active site 82654004357 I-site; other site 82654004358 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 82654004359 Mrr N-terminal domain; Region: Mrr_N; pfam14338 82654004360 Restriction endonuclease; Region: Mrr_cat; pfam04471 82654004361 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654004362 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654004363 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654004364 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654004365 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654004366 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654004367 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654004368 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654004369 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654004370 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 82654004371 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 82654004372 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 82654004373 TPP-binding site [chemical binding]; other site 82654004374 PYR/PP interface [polypeptide binding]; other site 82654004375 dimer interface [polypeptide binding]; other site 82654004376 TPP binding site [chemical binding]; other site 82654004377 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 82654004378 PAS domain S-box; Region: sensory_box; TIGR00229 82654004379 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654004380 putative active site [active] 82654004381 heme pocket [chemical binding]; other site 82654004382 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654004383 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654004384 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654004385 PAS domain; Region: PAS_9; pfam13426 82654004386 putative active site [active] 82654004387 heme pocket [chemical binding]; other site 82654004388 PAS domain; Region: PAS_9; pfam13426 82654004389 PAS domain S-box; Region: sensory_box; TIGR00229 82654004390 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654004391 putative active site [active] 82654004392 heme pocket [chemical binding]; other site 82654004393 PAS domain; Region: PAS_9; pfam13426 82654004394 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654004395 putative active site [active] 82654004396 heme pocket [chemical binding]; other site 82654004397 PAS domain S-box; Region: sensory_box; TIGR00229 82654004398 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654004399 putative active site [active] 82654004400 heme pocket [chemical binding]; other site 82654004401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654004402 dimer interface [polypeptide binding]; other site 82654004403 phosphorylation site [posttranslational modification] 82654004404 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 82654004405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654004406 ATP binding site [chemical binding]; other site 82654004407 G-X-G motif; other site 82654004408 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 82654004409 aromatic acid decarboxylase; Validated; Region: PRK05920 82654004410 Flavoprotein; Region: Flavoprotein; pfam02441 82654004411 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 82654004412 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654004413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654004414 active site 82654004415 phosphorylation site [posttranslational modification] 82654004416 intermolecular recognition site; other site 82654004417 dimerization interface [polypeptide binding]; other site 82654004418 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654004419 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654004420 dimer interface [polypeptide binding]; other site 82654004421 phosphorylation site [posttranslational modification] 82654004422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654004423 ATP binding site [chemical binding]; other site 82654004424 Mg2+ binding site [ion binding]; other site 82654004425 G-X-G motif; other site 82654004426 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 82654004427 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 82654004428 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 82654004429 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 82654004430 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 82654004431 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 82654004432 putative active site pocket [active] 82654004433 dimerization interface [polypeptide binding]; other site 82654004434 putative catalytic residue [active] 82654004435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654004436 S-adenosylmethionine binding site [chemical binding]; other site 82654004437 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 82654004438 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 82654004439 L-lactate permease; Region: Lactate_perm; cl00701 82654004440 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 82654004441 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 82654004442 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 82654004443 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 82654004444 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 82654004445 proline aminopeptidase P II; Provisional; Region: PRK10879 82654004446 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 82654004447 active site 82654004448 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 82654004449 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 82654004450 metal binding site 2 [ion binding]; metal-binding site 82654004451 putative DNA binding helix; other site 82654004452 metal binding site 1 [ion binding]; metal-binding site 82654004453 dimer interface [polypeptide binding]; other site 82654004454 structural Zn2+ binding site [ion binding]; other site 82654004455 glutamine synthetase, type I; Region: GlnA; TIGR00653 82654004456 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 82654004457 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 82654004458 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 82654004459 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 82654004460 dimer interface [polypeptide binding]; other site 82654004461 catalytic triad [active] 82654004462 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 82654004463 heme-binding site [chemical binding]; other site 82654004464 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 82654004465 Excalibur calcium-binding domain; Region: Excalibur; cl05460 82654004466 Excalibur calcium-binding domain; Region: Excalibur; cl05460 82654004467 Ycf27; Reviewed; Region: orf27; CHL00148 82654004468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654004469 active site 82654004470 phosphorylation site [posttranslational modification] 82654004471 intermolecular recognition site; other site 82654004472 dimerization interface [polypeptide binding]; other site 82654004473 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 82654004474 DNA binding site [nucleotide binding] 82654004475 light-harvesting-like protein 3; Provisional; Region: PLN00014 82654004476 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 82654004477 lipoprotein signal peptidase; Provisional; Region: PRK14787 82654004478 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 82654004479 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 82654004480 active site 82654004481 dimer interface [polypeptide binding]; other site 82654004482 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 82654004483 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 82654004484 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654004485 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654004486 dimer interface [polypeptide binding]; other site 82654004487 phosphorylation site [posttranslational modification] 82654004488 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 82654004489 protein I interface; other site 82654004490 D2 interface; other site 82654004491 protein T interface; other site 82654004492 chlorophyll binding site; other site 82654004493 beta carotene binding site; other site 82654004494 pheophytin binding site; other site 82654004495 manganese-stabilizing polypeptide interface; other site 82654004496 CP43 interface; other site 82654004497 protein L interface; other site 82654004498 oxygen evolving complex binding site; other site 82654004499 bromide binding site; other site 82654004500 quinone binding site; other site 82654004501 Fe binding site [ion binding]; other site 82654004502 core light harvesting interface; other site 82654004503 cytochrome b559 alpha subunit interface; other site 82654004504 cytochrome c-550 interface; other site 82654004505 protein J interface; other site 82654004506 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 82654004507 FAD binding domain; Region: FAD_binding_4; pfam01565 82654004508 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 82654004509 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 82654004510 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 82654004511 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 82654004512 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 82654004513 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 82654004514 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 82654004515 ligand binding site [chemical binding]; other site 82654004516 flexible hinge region; other site 82654004517 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 82654004518 putative switch regulator; other site 82654004519 non-specific DNA interactions [nucleotide binding]; other site 82654004520 DNA binding site [nucleotide binding] 82654004521 sequence specific DNA binding site [nucleotide binding]; other site 82654004522 putative cAMP binding site [chemical binding]; other site 82654004523 tellurium resistance terB-like protein; Region: terB_like; cd07177 82654004524 metal binding site [ion binding]; metal-binding site 82654004525 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 82654004526 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 82654004527 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 82654004528 O-Antigen ligase; Region: Wzy_C; pfam04932 82654004529 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654004530 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654004531 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654004532 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654004533 histidinol-phosphate aminotransferase; Provisional; Region: PRK02610 82654004534 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 82654004535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 82654004536 homodimer interface [polypeptide binding]; other site 82654004537 catalytic residue [active] 82654004538 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 82654004539 active site 82654004540 hydrophilic channel; other site 82654004541 dimerization interface [polypeptide binding]; other site 82654004542 catalytic residues [active] 82654004543 active site lid [active] 82654004544 integral membrane protein MviN; Region: mviN; TIGR01695 82654004545 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 82654004546 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 82654004547 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 82654004548 catalytic loop [active] 82654004549 iron binding site [ion binding]; other site 82654004550 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 82654004551 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654004552 active site 82654004553 ATP binding site [chemical binding]; other site 82654004554 substrate binding site [chemical binding]; other site 82654004555 activation loop (A-loop); other site 82654004556 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 82654004557 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 82654004558 active site 82654004559 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 82654004560 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 82654004561 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 82654004562 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 82654004563 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 82654004564 pyridoxal 5'-phosphate binding site [chemical binding]; other site 82654004565 homodimer interface [polypeptide binding]; other site 82654004566 catalytic residue [active] 82654004567 Zeta toxin; Region: Zeta_toxin; pfam06414 82654004568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 82654004569 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 82654004570 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 82654004571 trimer interface [polypeptide binding]; other site 82654004572 putative metal binding site [ion binding]; other site 82654004573 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654004574 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 82654004575 dimerization interface [polypeptide binding]; other site 82654004576 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654004577 dimer interface [polypeptide binding]; other site 82654004578 phosphorylation site [posttranslational modification] 82654004579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654004580 ATP binding site [chemical binding]; other site 82654004581 Mg2+ binding site [ion binding]; other site 82654004582 G-X-G motif; other site 82654004583 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 82654004584 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 82654004585 NAD binding site [chemical binding]; other site 82654004586 substrate binding site [chemical binding]; other site 82654004587 homodimer interface [polypeptide binding]; other site 82654004588 active site 82654004589 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 82654004590 ligand-binding site [chemical binding]; other site 82654004591 hypothetical protein; Provisional; Region: PRK07208 82654004592 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 82654004593 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 82654004594 S-layer homology domain; Region: SLH; pfam00395 82654004595 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 82654004596 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 82654004597 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 82654004598 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 82654004599 FMN binding site [chemical binding]; other site 82654004600 active site 82654004601 catalytic residues [active] 82654004602 substrate binding site [chemical binding]; other site 82654004603 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 82654004604 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 82654004605 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 82654004606 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 82654004607 active site 82654004608 metal binding site [ion binding]; metal-binding site 82654004609 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 82654004610 PemK-like protein; Region: PemK; pfam02452 82654004611 Methyltransferase domain; Region: Methyltransf_31; pfam13847 82654004612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654004613 S-adenosylmethionine binding site [chemical binding]; other site 82654004614 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 82654004615 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 82654004616 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 82654004617 catalytic residue [active] 82654004618 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 82654004619 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 82654004620 4Fe-4S binding domain; Region: Fer4; pfam00037 82654004621 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 82654004622 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 82654004623 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 82654004624 active site 82654004625 metal binding site [ion binding]; metal-binding site 82654004626 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 82654004627 YCII-related domain; Region: YCII; cl00999 82654004628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 82654004629 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 82654004630 HAS barrel domain; Region: HAS-barrel; pfam09378 82654004631 Domain of unknown function DUF87; Region: DUF87; pfam01935 82654004632 AAA-like domain; Region: AAA_10; pfam12846 82654004633 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 82654004634 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 82654004635 active site 82654004636 intersubunit interface [polypeptide binding]; other site 82654004637 catalytic residue [active] 82654004638 Peptidase family M48; Region: Peptidase_M48; pfam01435 82654004639 quinolinate synthetase; Provisional; Region: PRK09375 82654004640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654004641 binding surface 82654004642 TPR motif; other site 82654004643 TPR repeat; Region: TPR_11; pfam13414 82654004644 TPR repeat; Region: TPR_11; pfam13414 82654004645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654004646 binding surface 82654004647 TPR motif; other site 82654004648 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654004649 binding surface 82654004650 TPR repeat; Region: TPR_11; pfam13414 82654004651 TPR motif; other site 82654004652 TPR repeat; Region: TPR_11; pfam13414 82654004653 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 82654004654 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654004655 active site 82654004656 ATP binding site [chemical binding]; other site 82654004657 substrate binding site [chemical binding]; other site 82654004658 activation loop (A-loop); other site 82654004659 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 82654004660 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 82654004661 Predicted membrane protein [Function unknown]; Region: COG4709 82654004662 Peptidase family M48; Region: Peptidase_M48; cl12018 82654004663 Cache domain; Region: Cache_1; pfam02743 82654004664 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654004665 HAMP domain; Region: HAMP; pfam00672 82654004666 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654004667 dimer interface [polypeptide binding]; other site 82654004668 phosphorylation site [posttranslational modification] 82654004669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654004670 ATP binding site [chemical binding]; other site 82654004671 Mg2+ binding site [ion binding]; other site 82654004672 G-X-G motif; other site 82654004673 Response regulator receiver domain; Region: Response_reg; pfam00072 82654004674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654004675 active site 82654004676 phosphorylation site [posttranslational modification] 82654004677 intermolecular recognition site; other site 82654004678 dimerization interface [polypeptide binding]; other site 82654004679 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 82654004680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654004681 Walker A motif; other site 82654004682 ATP binding site [chemical binding]; other site 82654004683 Integrase core domain; Region: rve; pfam00665 82654004684 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 82654004685 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 82654004686 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 82654004687 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 82654004688 active site 82654004689 cosubstrate binding site; other site 82654004690 substrate binding site [chemical binding]; other site 82654004691 catalytic site [active] 82654004692 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_1; cd08821 82654004693 putative active site [active] 82654004694 putative substrate binding site [chemical binding]; other site 82654004695 putative cosubstrate binding site; other site 82654004696 catalytic site [active] 82654004697 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 82654004698 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 82654004699 Walker A/P-loop; other site 82654004700 ATP binding site [chemical binding]; other site 82654004701 Q-loop/lid; other site 82654004702 ABC transporter signature motif; other site 82654004703 Walker B; other site 82654004704 D-loop; other site 82654004705 H-loop/switch region; other site 82654004706 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 82654004707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654004708 dimer interface [polypeptide binding]; other site 82654004709 conserved gate region; other site 82654004710 putative PBP binding loops; other site 82654004711 ABC-ATPase subunit interface; other site 82654004712 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 82654004713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654004714 dimer interface [polypeptide binding]; other site 82654004715 conserved gate region; other site 82654004716 putative PBP binding loops; other site 82654004717 ABC-ATPase subunit interface; other site 82654004718 PBP superfamily domain; Region: PBP_like_2; cl17296 82654004719 hydrolase, alpha/beta fold family protein; Region: PLN02824 82654004720 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 82654004721 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 82654004722 PGAP1-like protein; Region: PGAP1; pfam07819 82654004723 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 82654004724 dimerization interface [polypeptide binding]; other site 82654004725 GAF domain; Region: GAF_3; pfam13492 82654004726 PAS fold; Region: PAS; pfam00989 82654004727 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 82654004728 putative active site [active] 82654004729 heme pocket [chemical binding]; other site 82654004730 GAF domain; Region: GAF_3; pfam13492 82654004731 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654004732 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654004733 dimer interface [polypeptide binding]; other site 82654004734 phosphorylation site [posttranslational modification] 82654004735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654004736 ATP binding site [chemical binding]; other site 82654004737 Mg2+ binding site [ion binding]; other site 82654004738 G-X-G motif; other site 82654004739 Copper resistance protein D; Region: CopD; cl00563 82654004740 teichoic acids export protein ATP-binding subunit; Provisional; Region: tagH; PRK13545 82654004741 GTPase CgtA; Reviewed; Region: obgE; PRK12299 82654004742 GTP1/OBG; Region: GTP1_OBG; pfam01018 82654004743 Obg GTPase; Region: Obg; cd01898 82654004744 G1 box; other site 82654004745 GTP/Mg2+ binding site [chemical binding]; other site 82654004746 Switch I region; other site 82654004747 G2 box; other site 82654004748 G3 box; other site 82654004749 Switch II region; other site 82654004750 G4 box; other site 82654004751 G5 box; other site 82654004752 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 82654004753 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 82654004754 recombinase A; Provisional; Region: recA; PRK09354 82654004755 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 82654004756 hexamer interface [polypeptide binding]; other site 82654004757 Walker A motif; other site 82654004758 ATP binding site [chemical binding]; other site 82654004759 Walker B motif; other site 82654004760 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 82654004761 Peptidase family M23; Region: Peptidase_M23; pfam01551 82654004762 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 82654004763 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 82654004764 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 82654004765 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 82654004766 Ion transport protein; Region: Ion_trans; pfam00520 82654004767 Ion channel; Region: Ion_trans_2; pfam07885 82654004768 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 82654004769 Double zinc ribbon; Region: DZR; pfam12773 82654004770 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 82654004771 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 82654004772 Homeodomain-like domain; Region: HTH_23; pfam13384 82654004773 Winged helix-turn helix; Region: HTH_29; pfam13551 82654004774 Winged helix-turn helix; Region: HTH_33; pfam13592 82654004775 DDE superfamily endonuclease; Region: DDE_3; pfam13358 82654004776 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 82654004777 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 82654004778 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 82654004779 putative NAD(P) binding site [chemical binding]; other site 82654004780 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 82654004781 anti sigma factor interaction site; other site 82654004782 regulatory phosphorylation site [posttranslational modification]; other site 82654004783 Iron permease FTR1 family; Region: FTR1; cl00475 82654004784 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 82654004785 Bacterial sugar transferase; Region: Bac_transf; pfam02397 82654004786 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 82654004787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 82654004788 non-specific DNA binding site [nucleotide binding]; other site 82654004789 salt bridge; other site 82654004790 sequence-specific DNA binding site [nucleotide binding]; other site 82654004791 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 82654004792 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 82654004793 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 82654004794 Mechanosensitive ion channel; Region: MS_channel; pfam00924 82654004795 Fic family protein [Function unknown]; Region: COG3177 82654004796 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 82654004797 Fic/DOC family; Region: Fic; pfam02661 82654004798 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 82654004799 Cupin-like domain; Region: Cupin_8; pfam13621 82654004800 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613 82654004801 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 82654004802 putative active site [active] 82654004803 catalytic site [active] 82654004804 putative metal binding site [ion binding]; other site 82654004805 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 82654004806 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 82654004807 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 82654004808 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 82654004809 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 82654004810 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 82654004811 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 82654004812 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 82654004813 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 82654004814 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 82654004815 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 82654004816 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 82654004817 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 82654004818 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 82654004819 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 82654004820 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 82654004821 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 82654004822 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 82654004823 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 82654004824 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 82654004825 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 82654004826 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 82654004827 tetramerization interface [polypeptide binding]; other site 82654004828 active site 82654004829 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 82654004830 NurA nuclease; Region: NurA; smart00933 82654004831 NurA nuclease; Region: NurA; smart00933 82654004832 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 82654004833 active site 82654004834 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 82654004835 S-layer homology domain; Region: SLH; pfam00395 82654004836 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 82654004837 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 82654004838 catalytic core [active] 82654004839 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 82654004840 Chain length determinant protein; Region: Wzz; pfam02706 82654004841 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 82654004842 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 82654004843 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 82654004844 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 82654004845 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 82654004846 Flavoprotein; Region: Flavoprotein; pfam02441 82654004847 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 82654004848 recombination protein RecR; Reviewed; Region: recR; PRK00076 82654004849 RecR protein; Region: RecR; pfam02132 82654004850 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 82654004851 putative active site [active] 82654004852 putative metal-binding site [ion binding]; other site 82654004853 tetramer interface [polypeptide binding]; other site 82654004854 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 82654004855 ATP cone domain; Region: ATP-cone; pfam03477 82654004856 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 82654004857 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 82654004858 Mg++ binding site [ion binding]; other site 82654004859 putative catalytic motif [active] 82654004860 putative substrate binding site [chemical binding]; other site 82654004861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 82654004862 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654004863 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 82654004864 putative ADP-binding pocket [chemical binding]; other site 82654004865 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654004866 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 82654004867 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 82654004868 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 82654004869 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 82654004870 active site 82654004871 Repair protein; Region: Repair_PSII; pfam04536 82654004872 DNA polymerase III subunit beta; Validated; Region: PRK05643 82654004873 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 82654004874 putative DNA binding surface [nucleotide binding]; other site 82654004875 dimer interface [polypeptide binding]; other site 82654004876 beta-clamp/clamp loader binding surface; other site 82654004877 beta-clamp/translesion DNA polymerase binding surface; other site 82654004878 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 82654004879 Predicted membrane protein [Function unknown]; Region: COG2119 82654004880 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 82654004881 Response regulator receiver domain; Region: Response_reg; pfam00072 82654004882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654004883 active site 82654004884 phosphorylation site [posttranslational modification] 82654004885 intermolecular recognition site; other site 82654004886 dimerization interface [polypeptide binding]; other site 82654004887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654004888 ATP binding site [chemical binding]; other site 82654004889 Mg2+ binding site [ion binding]; other site 82654004890 G-X-G motif; other site 82654004891 Bacterial Ig-like domain; Region: Big_5; pfam13205 82654004892 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 82654004893 MG2 domain; Region: A2M_N; pfam01835 82654004894 Alpha-2-macroglobulin family; Region: A2M; pfam00207 82654004895 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 82654004896 Putative capsular polysaccharide synthesis protein; Region: NKWYS; pfam10364 82654004897 FecR protein; Region: FecR; pfam04773 82654004898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654004899 dimer interface [polypeptide binding]; other site 82654004900 conserved gate region; other site 82654004901 putative PBP binding loops; other site 82654004902 ABC-ATPase subunit interface; other site 82654004903 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 82654004904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654004905 dimer interface [polypeptide binding]; other site 82654004906 conserved gate region; other site 82654004907 putative PBP binding loops; other site 82654004908 ABC-ATPase subunit interface; other site 82654004909 Uncharacterized conserved protein [Function unknown]; Region: COG1434 82654004910 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 82654004911 putative active site [active] 82654004912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 82654004913 FIST N domain; Region: FIST; pfam08495 82654004914 FIST C domain; Region: FIST_C; pfam10442 82654004915 Phycobilisome protein; Region: Phycobilisome; cl08227 82654004916 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 82654004917 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 82654004918 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 82654004919 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 82654004920 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 82654004921 putative dimerization interface [polypeptide binding]; other site 82654004922 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 82654004923 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 82654004924 dimerization interface [polypeptide binding]; other site 82654004925 active site 82654004926 metal binding site [ion binding]; metal-binding site 82654004927 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 82654004928 dsRNA binding site [nucleotide binding]; other site 82654004929 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 82654004930 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 82654004931 putative ligand binding site [chemical binding]; other site 82654004932 Response regulator receiver domain; Region: Response_reg; pfam00072 82654004933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654004934 active site 82654004935 phosphorylation site [posttranslational modification] 82654004936 intermolecular recognition site; other site 82654004937 dimerization interface [polypeptide binding]; other site 82654004938 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 82654004939 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 82654004940 RNA binding surface [nucleotide binding]; other site 82654004941 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 82654004942 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 82654004943 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 82654004944 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 82654004945 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 82654004946 Walker A/P-loop; other site 82654004947 ATP binding site [chemical binding]; other site 82654004948 Q-loop/lid; other site 82654004949 ABC transporter signature motif; other site 82654004950 Walker B; other site 82654004951 D-loop; other site 82654004952 H-loop/switch region; other site 82654004953 photosystem II protein I; Region: psbI; CHL00024 82654004954 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654004955 binding surface 82654004956 TPR motif; other site 82654004957 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 82654004958 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 82654004959 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 82654004960 trimer interface [polypeptide binding]; other site 82654004961 active site 82654004962 UDP-GlcNAc binding site [chemical binding]; other site 82654004963 lipid binding site [chemical binding]; lipid-binding site 82654004964 DnaJ domain; Region: DnaJ; pfam00226 82654004965 HSP70 interaction site [polypeptide binding]; other site 82654004966 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 82654004967 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 82654004968 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 82654004969 active site 82654004970 homodimer interface [polypeptide binding]; other site 82654004971 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 82654004972 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 82654004973 metal binding site [ion binding]; metal-binding site 82654004974 active site 82654004975 I-site; other site 82654004976 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 82654004977 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 82654004978 dimer interface [polypeptide binding]; other site 82654004979 anticodon binding site; other site 82654004980 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 82654004981 homodimer interface [polypeptide binding]; other site 82654004982 motif 1; other site 82654004983 active site 82654004984 motif 2; other site 82654004985 GAD domain; Region: GAD; pfam02938 82654004986 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 82654004987 active site 82654004988 motif 3; other site 82654004989 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654004990 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654004991 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654004992 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 82654004993 Cysteine-rich domain; Region: CCG; pfam02754 82654004994 Cysteine-rich domain; Region: CCG; pfam02754 82654004995 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 82654004996 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 82654004997 substrate binding site [chemical binding]; other site 82654004998 active site 82654004999 catalytic residues [active] 82654005000 heterodimer interface [polypeptide binding]; other site 82654005001 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 82654005002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654005003 Walker A motif; other site 82654005004 ATP binding site [chemical binding]; other site 82654005005 Walker B motif; other site 82654005006 arginine finger; other site 82654005007 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 82654005008 Stage II sporulation protein; Region: SpoIID; pfam08486 82654005009 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 82654005010 ATP-grasp domain; Region: ATP-grasp_4; cl17255 82654005011 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 82654005012 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 82654005013 active site 82654005014 motif I; other site 82654005015 motif II; other site 82654005016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 82654005017 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 82654005018 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 82654005019 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 82654005020 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 82654005021 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 82654005022 homodimer interface [polypeptide binding]; other site 82654005023 metal binding site [ion binding]; metal-binding site 82654005024 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 82654005025 homodimer interface [polypeptide binding]; other site 82654005026 active site 82654005027 putative chemical substrate binding site [chemical binding]; other site 82654005028 metal binding site [ion binding]; metal-binding site 82654005029 Maf-like protein; Region: Maf; pfam02545 82654005030 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 82654005031 active site 82654005032 dimer interface [polypeptide binding]; other site 82654005033 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 82654005034 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 82654005035 HflX GTPase family; Region: HflX; cd01878 82654005036 G1 box; other site 82654005037 GTP/Mg2+ binding site [chemical binding]; other site 82654005038 Switch I region; other site 82654005039 G2 box; other site 82654005040 G3 box; other site 82654005041 Switch II region; other site 82654005042 G4 box; other site 82654005043 G5 box; other site 82654005044 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 82654005045 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 82654005046 TIGR02302 family protein; Region: aProt_lowcomp 82654005047 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 82654005048 Na binding site [ion binding]; other site 82654005049 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 82654005050 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 82654005051 catalytic residues [active] 82654005052 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 82654005053 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 82654005054 active site 82654005055 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 82654005056 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 82654005057 homooctamer interface [polypeptide binding]; other site 82654005058 active site 82654005059 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 82654005060 RNA/DNA hybrid binding site [nucleotide binding]; other site 82654005061 active site 82654005062 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 82654005063 MgtE intracellular N domain; Region: MgtE_N; smart00924 82654005064 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 82654005065 Divalent cation transporter; Region: MgtE; pfam01769 82654005066 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 82654005067 DNA methylase; Region: N6_N4_Mtase; pfam01555 82654005068 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 82654005069 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654005070 Walker A motif; other site 82654005071 ATP binding site [chemical binding]; other site 82654005072 Walker B motif; other site 82654005073 The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1...; Region: PB1; cl02720 82654005074 PB1 interaction surface [polypeptide binding]; other site 82654005075 arginine finger; other site 82654005076 PB1 interaction site [polypeptide binding]; other site 82654005077 PB1 interaction site [polypeptide binding]; other site 82654005078 PB1 interaction surface [polypeptide binding]; other site 82654005079 PB1 interaction surface [polypeptide binding]; other site 82654005080 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 82654005081 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 82654005082 hydroxyglutarate oxidase; Provisional; Region: PRK11728 82654005083 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 82654005084 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 82654005085 Walker A/P-loop; other site 82654005086 ATP binding site [chemical binding]; other site 82654005087 Q-loop/lid; other site 82654005088 ABC transporter signature motif; other site 82654005089 Walker B; other site 82654005090 D-loop; other site 82654005091 H-loop/switch region; other site 82654005092 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 82654005093 NADH(P)-binding; Region: NAD_binding_10; pfam13460 82654005094 NAD(P) binding site [chemical binding]; other site 82654005095 putative active site [active] 82654005096 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 82654005097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 82654005098 anthranilate synthase component I-like protein; Validated; Region: PRK05940 82654005099 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 82654005100 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 82654005101 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 82654005102 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 82654005103 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 82654005104 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 82654005105 ligand binding site [chemical binding]; other site 82654005106 flexible hinge region; other site 82654005107 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 82654005108 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 82654005109 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 82654005110 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 82654005111 Transcriptional regulators [Transcription]; Region: MarR; COG1846 82654005112 MarR family; Region: MarR_2; pfam12802 82654005113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 82654005114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654005115 S-adenosylmethionine binding site [chemical binding]; other site 82654005116 c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177 82654005117 ResB-like family; Region: ResB; pfam05140 82654005118 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654005119 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654005120 EamA-like transporter family; Region: EamA; cl17759 82654005121 Response regulator receiver domain; Region: Response_reg; pfam00072 82654005122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654005123 active site 82654005124 phosphorylation site [posttranslational modification] 82654005125 intermolecular recognition site; other site 82654005126 dimerization interface [polypeptide binding]; other site 82654005127 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 82654005128 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 82654005129 HSP70 interaction site [polypeptide binding]; other site 82654005130 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654005131 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654005132 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 82654005133 EamA-like transporter family; Region: EamA; pfam00892 82654005134 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 82654005135 EamA-like transporter family; Region: EamA; pfam00892 82654005136 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 82654005137 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 82654005138 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 82654005139 Walker A/P-loop; other site 82654005140 ATP binding site [chemical binding]; other site 82654005141 Q-loop/lid; other site 82654005142 ABC transporter signature motif; other site 82654005143 Walker B; other site 82654005144 D-loop; other site 82654005145 H-loop/switch region; other site 82654005146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654005147 Walker A/P-loop; other site 82654005148 ATP binding site [chemical binding]; other site 82654005149 Q-loop/lid; other site 82654005150 ABC transporter signature motif; other site 82654005151 Walker B; other site 82654005152 D-loop; other site 82654005153 H-loop/switch region; other site 82654005154 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 82654005155 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 82654005156 TM-ABC transporter signature motif; other site 82654005157 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 82654005158 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 82654005159 TM-ABC transporter signature motif; other site 82654005160 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 82654005161 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 82654005162 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 82654005163 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 82654005164 NAD binding site [chemical binding]; other site 82654005165 substrate binding site [chemical binding]; other site 82654005166 active site 82654005167 Response regulator receiver domain; Region: Response_reg; pfam00072 82654005168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654005169 active site 82654005170 phosphorylation site [posttranslational modification] 82654005171 intermolecular recognition site; other site 82654005172 dimerization interface [polypeptide binding]; other site 82654005173 Response regulator receiver domain; Region: Response_reg; pfam00072 82654005174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654005175 active site 82654005176 phosphorylation site [posttranslational modification] 82654005177 intermolecular recognition site; other site 82654005178 dimerization interface [polypeptide binding]; other site 82654005179 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 82654005180 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 82654005181 metal binding site [ion binding]; metal-binding site 82654005182 active site 82654005183 I-site; other site 82654005184 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654005185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654005186 active site 82654005187 phosphorylation site [posttranslational modification] 82654005188 intermolecular recognition site; other site 82654005189 dimerization interface [polypeptide binding]; other site 82654005190 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 82654005191 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 82654005192 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 82654005193 putative dimerization interface [polypeptide binding]; other site 82654005194 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 82654005195 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 82654005196 Walker A/P-loop; other site 82654005197 ATP binding site [chemical binding]; other site 82654005198 Q-loop/lid; other site 82654005199 ABC transporter signature motif; other site 82654005200 Walker B; other site 82654005201 D-loop; other site 82654005202 H-loop/switch region; other site 82654005203 TOBE-like domain; Region: TOBE_3; pfam12857 82654005204 flavoprotein, HI0933 family; Region: TIGR00275 82654005205 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 82654005206 Amino acid permease; Region: AA_permease; pfam00324 82654005207 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 82654005208 NAD(P) binding pocket [chemical binding]; other site 82654005209 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 82654005210 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 82654005211 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 82654005212 core domain interface [polypeptide binding]; other site 82654005213 delta subunit interface [polypeptide binding]; other site 82654005214 epsilon subunit interface [polypeptide binding]; other site 82654005215 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654005216 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 82654005217 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654005218 PAS domain; Region: PAS_9; pfam13426 82654005219 putative active site [active] 82654005220 heme pocket [chemical binding]; other site 82654005221 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654005222 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654005223 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 82654005224 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 82654005225 metal binding site [ion binding]; metal-binding site 82654005226 active site 82654005227 I-site; other site 82654005228 CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216 82654005229 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 82654005230 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 82654005231 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 82654005232 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 82654005233 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 82654005234 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 82654005235 Hexamer interface [polypeptide binding]; other site 82654005236 Hexagonal pore residue; other site 82654005237 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 82654005238 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 82654005239 Hexamer interface [polypeptide binding]; other site 82654005240 Hexagonal pore residue; other site 82654005241 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 82654005242 Hexamer/Pentamer interface [polypeptide binding]; other site 82654005243 central pore; other site 82654005244 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 82654005245 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 82654005246 trimer interface [polypeptide binding]; other site 82654005247 active site 82654005248 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 82654005249 putative multimerization interface [polypeptide binding]; other site 82654005250 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 82654005251 putative multimerization interface [polypeptide binding]; other site 82654005252 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 82654005253 putative multimerization interface [polypeptide binding]; other site 82654005254 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 82654005255 putative multimerization interface [polypeptide binding]; other site 82654005256 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 82654005257 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 82654005258 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 82654005259 Hexamer interface [polypeptide binding]; other site 82654005260 Hexagonal pore residue; other site 82654005261 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 82654005262 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 82654005263 Hexamer interface [polypeptide binding]; other site 82654005264 Hexagonal pore residue; other site 82654005265 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 82654005266 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 82654005267 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 82654005268 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 82654005269 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 82654005270 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 82654005271 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 82654005272 NADH dehydrogenase; Region: NADHdh; cl00469 82654005273 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 82654005274 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 82654005275 NADH dehydrogenase subunit 7; Region: ndhH; CHL00017 82654005276 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 82654005277 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 82654005278 active site 82654005279 homodimer interface [polypeptide binding]; other site 82654005280 Exoribonuclease R [Transcription]; Region: VacB; COG0557 82654005281 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 82654005282 RNB domain; Region: RNB; pfam00773 82654005283 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 82654005284 RNA binding site [nucleotide binding]; other site 82654005285 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 82654005286 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 82654005287 putative ligand binding site [chemical binding]; other site 82654005288 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 82654005289 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 82654005290 TM-ABC transporter signature motif; other site 82654005291 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654005292 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 82654005293 dimerization interface [polypeptide binding]; other site 82654005294 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 82654005295 dimer interface [polypeptide binding]; other site 82654005296 phosphorylation site [posttranslational modification] 82654005297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654005298 ATP binding site [chemical binding]; other site 82654005299 Mg2+ binding site [ion binding]; other site 82654005300 G-X-G motif; other site 82654005301 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 82654005302 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 82654005303 TM-ABC transporter signature motif; other site 82654005304 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 82654005305 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 82654005306 Walker A/P-loop; other site 82654005307 ATP binding site [chemical binding]; other site 82654005308 Q-loop/lid; other site 82654005309 ABC transporter signature motif; other site 82654005310 Walker B; other site 82654005311 D-loop; other site 82654005312 H-loop/switch region; other site 82654005313 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654005314 Walker A/P-loop; other site 82654005315 ATP binding site [chemical binding]; other site 82654005316 Q-loop/lid; other site 82654005317 ABC transporter signature motif; other site 82654005318 Walker B; other site 82654005319 D-loop; other site 82654005320 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 82654005321 putative substrate binding pocket [chemical binding]; other site 82654005322 catalytic triad [active] 82654005323 AB domain interface; other site 82654005324 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 82654005325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654005326 Mg2+ binding site [ion binding]; other site 82654005327 G-X-G motif; other site 82654005328 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 82654005329 anchoring element; other site 82654005330 dimer interface [polypeptide binding]; other site 82654005331 ATP binding site [chemical binding]; other site 82654005332 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 82654005333 active site 82654005334 putative metal-binding site [ion binding]; other site 82654005335 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 82654005336 AAA domain; Region: AAA_21; pfam13304 82654005337 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654005338 Walker B; other site 82654005339 D-loop; other site 82654005340 H-loop/switch region; other site 82654005341 RloB-like protein; Region: RloB; pfam13707 82654005342 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 82654005343 Amidinotransferase; Region: Amidinotransf; cl12043 82654005344 Uncharacterized conserved protein [Function unknown]; Region: COG1915 82654005345 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 82654005346 homodimer interface [polypeptide binding]; other site 82654005347 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 82654005348 Mechanosensitive ion channel; Region: MS_channel; pfam00924 82654005349 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 82654005350 Coenzyme A binding pocket [chemical binding]; other site 82654005351 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 82654005352 photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049 82654005353 Uncharacterized conserved protein [Function unknown]; Region: COG2308 82654005354 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 82654005355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 82654005356 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 82654005357 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 82654005358 short chain dehydrogenase; Provisional; Region: PRK06500 82654005359 classical (c) SDRs; Region: SDR_c; cd05233 82654005360 NAD(P) binding site [chemical binding]; other site 82654005361 active site 82654005362 Uncharacterized conserved protein [Function unknown]; Region: COG1543 82654005363 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 82654005364 active site 82654005365 substrate binding site [chemical binding]; other site 82654005366 catalytic site [active] 82654005367 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 82654005368 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 82654005369 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 82654005370 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 82654005371 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 82654005372 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 82654005373 Zn binding site [ion binding]; other site 82654005374 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 82654005375 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 82654005376 putative metal binding site; other site 82654005377 Type II/IV secretion system protein; Region: T2SE; pfam00437 82654005378 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 82654005379 Walker A motif; other site 82654005380 ATP binding site [chemical binding]; other site 82654005381 Walker B motif; other site 82654005382 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 82654005383 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 82654005384 Walker A/P-loop; other site 82654005385 ATP binding site [chemical binding]; other site 82654005386 Q-loop/lid; other site 82654005387 ABC transporter signature motif; other site 82654005388 Walker B; other site 82654005389 D-loop; other site 82654005390 H-loop/switch region; other site 82654005391 TOBE domain; Region: TOBE_2; pfam08402 82654005392 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 82654005393 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 82654005394 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 82654005395 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 82654005396 NADP-binding site; other site 82654005397 homotetramer interface [polypeptide binding]; other site 82654005398 substrate binding site [chemical binding]; other site 82654005399 homodimer interface [polypeptide binding]; other site 82654005400 active site 82654005401 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 82654005402 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 82654005403 NADP binding site [chemical binding]; other site 82654005404 active site 82654005405 putative substrate binding site [chemical binding]; other site 82654005406 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 82654005407 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 82654005408 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 82654005409 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 82654005410 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 82654005411 DNA binding residues [nucleotide binding] 82654005412 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 82654005413 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 82654005414 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 82654005415 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 82654005416 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 82654005417 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 82654005418 dimer interface [polypeptide binding]; other site 82654005419 ssDNA binding site [nucleotide binding]; other site 82654005420 tetramer (dimer of dimers) interface [polypeptide binding]; other site 82654005421 Uncharacterized conserved protein [Function unknown]; Region: COG1359 82654005422 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 82654005423 Integral membrane protein DUF92; Region: DUF92; pfam01940 82654005424 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 82654005425 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 82654005426 ligand binding site [chemical binding]; other site 82654005427 flexible hinge region; other site 82654005428 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 82654005429 Protein of unknown function DUF72; Region: DUF72; cl00777 82654005430 Protein of unknown function DUF72; Region: DUF72; cl00777 82654005431 TPR repeat; Region: TPR_11; pfam13414 82654005432 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654005433 binding surface 82654005434 TPR motif; other site 82654005435 TPR repeat; Region: TPR_11; pfam13414 82654005436 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654005437 binding surface 82654005438 TPR motif; other site 82654005439 TPR repeat; Region: TPR_11; pfam13414 82654005440 TPR repeat; Region: TPR_11; pfam13414 82654005441 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654005442 binding surface 82654005443 TPR motif; other site 82654005444 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 82654005445 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 82654005446 putative binding surface; other site 82654005447 active site 82654005448 GUN4-like; Region: GUN4; pfam05419 82654005449 GUN4-like; Region: GUN4; pfam05419 82654005450 hypothetical protein; Validated; Region: PRK07411 82654005451 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 82654005452 ATP binding site [chemical binding]; other site 82654005453 substrate interface [chemical binding]; other site 82654005454 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 82654005455 active site residue [active] 82654005456 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 82654005457 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 82654005458 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 82654005459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654005460 S-adenosylmethionine binding site [chemical binding]; other site 82654005461 Protein of unknown function (DUF1517); Region: DUF1517; pfam07466 82654005462 cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665 82654005463 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654005464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654005465 active site 82654005466 phosphorylation site [posttranslational modification] 82654005467 intermolecular recognition site; other site 82654005468 dimerization interface [polypeptide binding]; other site 82654005469 PAS domain; Region: PAS_9; pfam13426 82654005470 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654005471 putative active site [active] 82654005472 heme pocket [chemical binding]; other site 82654005473 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654005474 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654005475 dimer interface [polypeptide binding]; other site 82654005476 phosphorylation site [posttranslational modification] 82654005477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654005478 ATP binding site [chemical binding]; other site 82654005479 Mg2+ binding site [ion binding]; other site 82654005480 G-X-G motif; other site 82654005481 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 82654005482 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 82654005483 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 82654005484 FeS/SAM binding site; other site 82654005485 V-type ATP synthase subunit I; Validated; Region: PRK05771 82654005486 V-type ATP synthase subunit K; Provisional; Region: PRK09621 82654005487 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 82654005488 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 82654005489 active site 82654005490 metal binding site [ion binding]; metal-binding site 82654005491 DNA binding site [nucleotide binding] 82654005492 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 82654005493 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 82654005494 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 82654005495 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 82654005496 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 82654005497 cell division protein ZipA; Provisional; Region: PRK01741 82654005498 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 82654005499 Fatty acid desaturase; Region: FA_desaturase; pfam00487 82654005500 putative di-iron ligands [ion binding]; other site 82654005501 Protein of unknown function (DUF760); Region: DUF760; pfam05542 82654005502 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 82654005503 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 82654005504 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 82654005505 Ligand Binding Site [chemical binding]; other site 82654005506 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 82654005507 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 82654005508 catalytic triad [active] 82654005509 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 82654005510 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 82654005511 BolA-like protein; Region: BolA; pfam01722 82654005512 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 82654005513 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654005514 putative active site [active] 82654005515 Integrase core domain; Region: rve; pfam00665 82654005516 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 82654005517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654005518 Walker A motif; other site 82654005519 ATP binding site [chemical binding]; other site 82654005520 photochlorophyllide reductase subunit B; Region: chlB; CHL00076 82654005521 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 82654005522 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 82654005523 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 82654005524 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 82654005525 RNA binding surface [nucleotide binding]; other site 82654005526 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 82654005527 active site 82654005528 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 82654005529 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 82654005530 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 82654005531 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 82654005532 homodimer interface [polypeptide binding]; other site 82654005533 Walker A motif; other site 82654005534 ATP binding site [chemical binding]; other site 82654005535 hydroxycobalamin binding site [chemical binding]; other site 82654005536 Walker B motif; other site 82654005537 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 82654005538 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 82654005539 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 82654005540 N-acetyl-D-glucosamine binding site [chemical binding]; other site 82654005541 catalytic residue [active] 82654005542 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 82654005543 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 82654005544 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 82654005545 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 82654005546 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 82654005547 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 82654005548 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 82654005549 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 82654005550 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 82654005551 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 82654005552 putative active site [active] 82654005553 putative metal binding site [ion binding]; other site 82654005554 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 82654005555 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 82654005556 catalytic loop [active] 82654005557 iron binding site [ion binding]; other site 82654005558 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 82654005559 metal ion-dependent adhesion site (MIDAS); other site 82654005560 Uncharacterized conserved protein [Function unknown]; Region: COG4748 82654005561 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 82654005562 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 82654005563 Response regulator receiver domain; Region: Response_reg; pfam00072 82654005564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654005565 active site 82654005566 phosphorylation site [posttranslational modification] 82654005567 intermolecular recognition site; other site 82654005568 dimerization interface [polypeptide binding]; other site 82654005569 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654005570 PAS domain; Region: PAS_9; pfam13426 82654005571 putative active site [active] 82654005572 heme pocket [chemical binding]; other site 82654005573 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654005574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654005575 active site 82654005576 phosphorylation site [posttranslational modification] 82654005577 intermolecular recognition site; other site 82654005578 dimerization interface [polypeptide binding]; other site 82654005579 PAS domain S-box; Region: sensory_box; TIGR00229 82654005580 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654005581 putative active site [active] 82654005582 heme pocket [chemical binding]; other site 82654005583 PAS domain S-box; Region: sensory_box; TIGR00229 82654005584 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654005585 putative active site [active] 82654005586 heme pocket [chemical binding]; other site 82654005587 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654005588 GAF domain; Region: GAF_3; pfam13492 82654005589 PAS domain S-box; Region: sensory_box; TIGR00229 82654005590 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654005591 putative active site [active] 82654005592 heme pocket [chemical binding]; other site 82654005593 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654005594 GAF domain; Region: GAF; pfam01590 82654005595 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654005596 PAS fold; Region: PAS_3; pfam08447 82654005597 putative active site [active] 82654005598 heme pocket [chemical binding]; other site 82654005599 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 82654005600 PAS domain S-box; Region: sensory_box; TIGR00229 82654005601 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654005602 putative active site [active] 82654005603 heme pocket [chemical binding]; other site 82654005604 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654005605 dimer interface [polypeptide binding]; other site 82654005606 phosphorylation site [posttranslational modification] 82654005607 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654005608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654005609 ATP binding site [chemical binding]; other site 82654005610 G-X-G motif; other site 82654005611 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 82654005612 cyanate hydratase; Validated; Region: PRK02866 82654005613 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 82654005614 oligomer interface [polypeptide binding]; other site 82654005615 active site 82654005616 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 82654005617 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 82654005618 Walker A/P-loop; other site 82654005619 ATP binding site [chemical binding]; other site 82654005620 Q-loop/lid; other site 82654005621 ABC transporter signature motif; other site 82654005622 Walker B; other site 82654005623 D-loop; other site 82654005624 H-loop/switch region; other site 82654005625 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 82654005626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654005627 dimer interface [polypeptide binding]; other site 82654005628 conserved gate region; other site 82654005629 putative PBP binding loops; other site 82654005630 ABC-ATPase subunit interface; other site 82654005631 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 82654005632 NMT1-like family; Region: NMT1_2; pfam13379 82654005633 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 82654005634 NMT1-like family; Region: NMT1_2; pfam13379 82654005635 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 82654005636 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 82654005637 Recombinase; Region: Recombinase; pfam07508 82654005638 H+ Antiporter protein; Region: 2A0121; TIGR00900 82654005639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 82654005640 putative substrate translocation pore; other site 82654005641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654005642 dimer interface [polypeptide binding]; other site 82654005643 phosphorylation site [posttranslational modification] 82654005644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654005645 ATP binding site [chemical binding]; other site 82654005646 Mg2+ binding site [ion binding]; other site 82654005647 G-X-G motif; other site 82654005648 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 82654005649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654005650 active site 82654005651 phosphorylation site [posttranslational modification] 82654005652 intermolecular recognition site; other site 82654005653 dimerization interface [polypeptide binding]; other site 82654005654 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 82654005655 DNA binding site [nucleotide binding] 82654005656 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 82654005657 Predicted metal-binding protein [General function prediction only]; Region: COG3019 82654005658 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 82654005659 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 82654005660 Soluble P-type ATPase [General function prediction only]; Region: COG4087 82654005661 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 82654005662 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 82654005663 Multicopper oxidase; Region: Cu-oxidase; pfam00394 82654005664 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 82654005665 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 82654005666 Nitrogen regulatory protein P-II; Region: P-II; smart00938 82654005667 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 82654005668 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 82654005669 active site 82654005670 OsmC-like protein; Region: OsmC; pfam02566 82654005671 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 82654005672 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 82654005673 DNA photolyase; Region: DNA_photolyase; pfam00875 82654005674 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 82654005675 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 82654005676 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 82654005677 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 82654005678 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 82654005679 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 82654005680 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 82654005681 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 82654005682 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 82654005683 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 82654005684 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 82654005685 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 82654005686 dimer interface [polypeptide binding]; other site 82654005687 catalytic triad [active] 82654005688 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 82654005689 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 82654005690 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 82654005691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654005692 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 82654005693 Walker A motif; other site 82654005694 Walker A/P-loop; other site 82654005695 ATP binding site [chemical binding]; other site 82654005696 ATP binding site [chemical binding]; other site 82654005697 Walker B motif; other site 82654005698 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 82654005699 methionine aminopeptidase; Provisional; Region: PRK08671 82654005700 active site 82654005701 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 82654005702 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 82654005703 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 82654005704 UbiA prenyltransferase family; Region: UbiA; pfam01040 82654005705 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 82654005706 translation initiation factor IF-2; Validated; Region: infB; PRK05306 82654005707 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 82654005708 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 82654005709 G1 box; other site 82654005710 putative GEF interaction site [polypeptide binding]; other site 82654005711 GTP/Mg2+ binding site [chemical binding]; other site 82654005712 Switch I region; other site 82654005713 G2 box; other site 82654005714 G3 box; other site 82654005715 Switch II region; other site 82654005716 G4 box; other site 82654005717 G5 box; other site 82654005718 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 82654005719 Translation-initiation factor 2; Region: IF-2; pfam11987 82654005720 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 82654005721 GTP-binding protein LepA; Provisional; Region: PRK05433 82654005722 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 82654005723 G1 box; other site 82654005724 putative GEF interaction site [polypeptide binding]; other site 82654005725 GTP/Mg2+ binding site [chemical binding]; other site 82654005726 Switch I region; other site 82654005727 G2 box; other site 82654005728 G3 box; other site 82654005729 Switch II region; other site 82654005730 G4 box; other site 82654005731 G5 box; other site 82654005732 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 82654005733 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 82654005734 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 82654005735 photosystem II subunit S (PsbS); Provisional; Region: PLN00084 82654005736 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 82654005737 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 82654005738 catalytic residue [active] 82654005739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 82654005740 pyrroline-5-carboxylate reductase; Region: PLN02688 82654005741 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 82654005742 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 82654005743 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 82654005744 dimerization interface [polypeptide binding]; other site 82654005745 putative ATP binding site [chemical binding]; other site 82654005746 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 82654005747 Ligand Binding Site [chemical binding]; other site 82654005748 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 82654005749 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 82654005750 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 82654005751 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 82654005752 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 82654005753 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654005754 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654005755 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654005756 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654005757 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654005758 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654005759 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654005760 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654005761 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654005762 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654005763 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654005764 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 82654005765 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 82654005766 dimer interface [polypeptide binding]; other site 82654005767 pyridoxal 5'-phosphate binding site [chemical binding]; other site 82654005768 catalytic residue [active] 82654005769 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 82654005770 active site 82654005771 8-oxo-dGMP binding site [chemical binding]; other site 82654005772 nudix motif; other site 82654005773 metal binding site [ion binding]; metal-binding site 82654005774 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 82654005775 Response regulator receiver domain; Region: Response_reg; pfam00072 82654005776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654005777 active site 82654005778 phosphorylation site [posttranslational modification] 82654005779 intermolecular recognition site; other site 82654005780 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654005781 dimerization interface [polypeptide binding]; other site 82654005782 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654005783 dimer interface [polypeptide binding]; other site 82654005784 phosphorylation site [posttranslational modification] 82654005785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654005786 ATP binding site [chemical binding]; other site 82654005787 Mg2+ binding site [ion binding]; other site 82654005788 G-X-G motif; other site 82654005789 biotin synthase; Region: bioB; TIGR00433 82654005790 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 82654005791 FeS/SAM binding site; other site 82654005792 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 82654005793 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 82654005794 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 82654005795 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 82654005796 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 82654005797 homodimer interface [polypeptide binding]; other site 82654005798 substrate-cofactor binding pocket; other site 82654005799 catalytic residue [active] 82654005800 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 82654005801 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 82654005802 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 82654005803 phosphopeptide binding site; other site 82654005804 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 82654005805 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 82654005806 putative C-terminal domain interface [polypeptide binding]; other site 82654005807 putative GSH binding site (G-site) [chemical binding]; other site 82654005808 putative dimer interface [polypeptide binding]; other site 82654005809 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 82654005810 N-terminal domain interface [polypeptide binding]; other site 82654005811 dimer interface [polypeptide binding]; other site 82654005812 substrate binding pocket (H-site) [chemical binding]; other site 82654005813 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 82654005814 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 82654005815 C-terminal domain interface [polypeptide binding]; other site 82654005816 GSH binding site (G-site) [chemical binding]; other site 82654005817 dimer interface [polypeptide binding]; other site 82654005818 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 82654005819 N-terminal domain interface [polypeptide binding]; other site 82654005820 dimer interface [polypeptide binding]; other site 82654005821 substrate binding pocket (H-site) [chemical binding]; other site 82654005822 Rubredoxin [Energy production and conversion]; Region: COG1773 82654005823 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 82654005824 iron binding site [ion binding]; other site 82654005825 Ycf48-like protein; Provisional; Region: PRK13684 82654005826 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 82654005827 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 82654005828 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 82654005829 Walker A motif; other site 82654005830 ATP binding site [chemical binding]; other site 82654005831 Walker B motif; other site 82654005832 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 82654005833 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 82654005834 Walker A motif; other site 82654005835 ATP binding site [chemical binding]; other site 82654005836 Walker B motif; other site 82654005837 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 82654005838 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 82654005839 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 82654005840 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 82654005841 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 82654005842 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 82654005843 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 82654005844 minor groove reading motif; other site 82654005845 helix-hairpin-helix signature motif; other site 82654005846 substrate binding pocket [chemical binding]; other site 82654005847 active site 82654005848 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 82654005849 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 82654005850 nitrilase; Region: PLN02798 82654005851 putative active site [active] 82654005852 catalytic triad [active] 82654005853 dimer interface [polypeptide binding]; other site 82654005854 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 82654005855 feedback inhibition sensing region; other site 82654005856 homohexameric interface [polypeptide binding]; other site 82654005857 nucleotide binding site [chemical binding]; other site 82654005858 N-acetyl-L-glutamate binding site [chemical binding]; other site 82654005859 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 82654005860 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 82654005861 phosphopeptide binding site; other site 82654005862 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654005863 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654005864 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 82654005865 cyclase homology domain; Region: CHD; cd07302 82654005866 nucleotidyl binding site; other site 82654005867 metal binding site [ion binding]; metal-binding site 82654005868 dimer interface [polypeptide binding]; other site 82654005869 NlpC/P60 family; Region: NLPC_P60; pfam00877 82654005870 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 82654005871 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 82654005872 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 82654005873 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 82654005874 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 82654005875 Ligand binding site; other site 82654005876 Putative Catalytic site; other site 82654005877 DXD motif; other site 82654005878 Predicted membrane protein [Function unknown]; Region: COG2246 82654005879 GtrA-like protein; Region: GtrA; pfam04138 82654005880 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 82654005881 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 82654005882 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 82654005883 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 82654005884 Coenzyme A binding pocket [chemical binding]; other site 82654005885 TIGR03545 family protein; Region: TIGR03545 82654005886 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 82654005887 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 82654005888 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 82654005889 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 82654005890 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 82654005891 yiaA/B two helix domain; Region: YiaAB; cl01759 82654005892 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 82654005893 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 82654005894 active site 82654005895 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 82654005896 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 82654005897 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 82654005898 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 82654005899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654005900 Walker A motif; other site 82654005901 ATP binding site [chemical binding]; other site 82654005902 Walker B motif; other site 82654005903 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 82654005904 RxxxH motif; other site 82654005905 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 82654005906 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 82654005907 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 82654005908 TrkA-N domain; Region: TrkA_N; pfam02254 82654005909 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654005910 putative active site [active] 82654005911 arogenate dehydrogenase; Reviewed; Region: PRK07417 82654005912 prephenate dehydrogenase; Validated; Region: PRK08507 82654005913 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 82654005914 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 82654005915 catalytic core [active] 82654005916 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 82654005917 catalytic core [active] 82654005918 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 82654005919 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 82654005920 homodimer interface [polypeptide binding]; other site 82654005921 oligonucleotide binding site [chemical binding]; other site 82654005922 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 82654005923 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 82654005924 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 82654005925 CAAX protease self-immunity; Region: Abi; pfam02517 82654005926 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 82654005927 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 82654005928 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 82654005929 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 82654005930 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 82654005931 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 82654005932 photosystem II protein K; Region: psbK; CHL00047 82654005933 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 82654005934 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 82654005935 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 82654005936 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 82654005937 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 82654005938 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654005939 Walker A/P-loop; other site 82654005940 ATP binding site [chemical binding]; other site 82654005941 Q-loop/lid; other site 82654005942 ABC transporter signature motif; other site 82654005943 Walker B; other site 82654005944 D-loop; other site 82654005945 H-loop/switch region; other site 82654005946 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 82654005947 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 82654005948 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 82654005949 ABC1 family; Region: ABC1; cl17513 82654005950 ABC1 family; Region: ABC1; cl17513 82654005951 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 82654005952 active site 82654005953 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 82654005954 active site residue [active] 82654005955 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 82654005956 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 82654005957 tetrameric interface [polypeptide binding]; other site 82654005958 activator binding site; other site 82654005959 NADP binding site [chemical binding]; other site 82654005960 substrate binding site [chemical binding]; other site 82654005961 catalytic residues [active] 82654005962 Domain of unknown function DUF11; Region: DUF11; pfam01345 82654005963 Calx-beta domain; Region: Calx-beta; cl02522 82654005964 Calx-beta domain; Region: Calx-beta; cl02522 82654005965 Calx-beta domain; Region: Calx-beta; cl02522 82654005966 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 82654005967 DNA polymerase I; Provisional; Region: PRK05755 82654005968 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 82654005969 active site 82654005970 metal binding site 1 [ion binding]; metal-binding site 82654005971 putative 5' ssDNA interaction site; other site 82654005972 metal binding site 3; metal-binding site 82654005973 metal binding site 2 [ion binding]; metal-binding site 82654005974 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 82654005975 putative DNA binding site [nucleotide binding]; other site 82654005976 putative metal binding site [ion binding]; other site 82654005977 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 82654005978 active site 82654005979 catalytic site [active] 82654005980 substrate binding site [chemical binding]; other site 82654005981 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 82654005982 active site 82654005983 DNA binding site [nucleotide binding] 82654005984 catalytic site [active] 82654005985 recombination protein F; Reviewed; Region: recF; PRK00064 82654005986 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 82654005987 Walker A/P-loop; other site 82654005988 ATP binding site [chemical binding]; other site 82654005989 Q-loop/lid; other site 82654005990 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654005991 ABC transporter signature motif; other site 82654005992 Walker B; other site 82654005993 D-loop; other site 82654005994 H-loop/switch region; other site 82654005995 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 82654005996 putative hydrophobic ligand binding site [chemical binding]; other site 82654005997 ribosomal protein L31; Validated; Region: rpl31; CHL00136 82654005998 peptide chain release factor 1; Validated; Region: prfA; PRK00591 82654005999 This domain is found in peptide chain release factors; Region: PCRF; smart00937 82654006000 RF-1 domain; Region: RF-1; pfam00472 82654006001 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654006002 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 82654006003 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 82654006004 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 82654006005 trimer interface [polypeptide binding]; other site 82654006006 active site 82654006007 substrate binding site [chemical binding]; other site 82654006008 CoA binding site [chemical binding]; other site 82654006009 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654006010 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 82654006011 putative ADP-binding pocket [chemical binding]; other site 82654006012 S-layer homology domain; Region: SLH; pfam00395 82654006013 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 82654006014 Predicted transcriptional regulators [Transcription]; Region: COG1733 82654006015 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 82654006016 putative DNA binding site [nucleotide binding]; other site 82654006017 dimerization interface [polypeptide binding]; other site 82654006018 putative Zn2+ binding site [ion binding]; other site 82654006019 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 82654006020 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 82654006021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654006022 Walker A/P-loop; other site 82654006023 ATP binding site [chemical binding]; other site 82654006024 Q-loop/lid; other site 82654006025 ABC transporter signature motif; other site 82654006026 Walker B; other site 82654006027 D-loop; other site 82654006028 H-loop/switch region; other site 82654006029 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 82654006030 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 82654006031 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 82654006032 Walker A/P-loop; other site 82654006033 ATP binding site [chemical binding]; other site 82654006034 Q-loop/lid; other site 82654006035 ABC transporter signature motif; other site 82654006036 Walker B; other site 82654006037 D-loop; other site 82654006038 H-loop/switch region; other site 82654006039 DNA adenine methylase (dam); Region: dam; TIGR00571 82654006040 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 82654006041 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 82654006042 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 82654006043 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 82654006044 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 82654006045 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 82654006046 active site 82654006047 substrate-binding site [chemical binding]; other site 82654006048 metal-binding site [ion binding] 82654006049 ATP binding site [chemical binding]; other site 82654006050 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 82654006051 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 82654006052 dimerization interface [polypeptide binding]; other site 82654006053 domain crossover interface; other site 82654006054 redox-dependent activation switch; other site 82654006055 polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813 82654006056 Uncharacterized conserved protein [Function unknown]; Region: COG0062 82654006057 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 82654006058 putative substrate binding site [chemical binding]; other site 82654006059 putative ATP binding site [chemical binding]; other site 82654006060 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 82654006061 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 82654006062 active site 82654006063 motif I; other site 82654006064 motif II; other site 82654006065 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879 82654006066 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 82654006067 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 82654006068 Domain of unknown function DUF20; Region: UPF0118; pfam01594 82654006069 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 82654006070 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 82654006071 active site 82654006072 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 82654006073 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 82654006074 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 82654006075 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 82654006076 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 82654006077 DNA binding residues [nucleotide binding] 82654006078 NB-ARC domain; Region: NB-ARC; pfam00931 82654006079 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 82654006080 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 82654006081 hydrophobic ligand binding site; other site 82654006082 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 82654006083 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 82654006084 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; pfam10063 82654006085 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 82654006086 Peptidase family M23; Region: Peptidase_M23; pfam01551 82654006087 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654006088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654006089 active site 82654006090 phosphorylation site [posttranslational modification] 82654006091 intermolecular recognition site; other site 82654006092 dimerization interface [polypeptide binding]; other site 82654006093 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 82654006094 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 82654006095 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 82654006096 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 82654006097 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 82654006098 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 82654006099 active site 82654006100 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 82654006101 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 82654006102 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 82654006103 active site 82654006104 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 82654006105 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654006106 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 82654006107 putative ADP-binding pocket [chemical binding]; other site 82654006108 Isochorismatase family; Region: Isochorismatase; pfam00857 82654006109 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 82654006110 catalytic triad [active] 82654006111 conserved cis-peptide bond; other site 82654006112 formamidase; Provisional; Region: amiF; PRK13287 82654006113 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 82654006114 multimer interface [polypeptide binding]; other site 82654006115 active site 82654006116 catalytic triad [active] 82654006117 dimer interface [polypeptide binding]; other site 82654006118 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 82654006119 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 82654006120 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 82654006121 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 82654006122 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 82654006123 NMT1-like family; Region: NMT1_2; pfam13379 82654006124 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 82654006125 Amidase; Region: Amidase; cl11426 82654006126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 82654006127 Coenzyme A binding pocket [chemical binding]; other site 82654006128 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 82654006129 DHH family; Region: DHH; pfam01368 82654006130 DHHA1 domain; Region: DHHA1; pfam02272 82654006131 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 82654006132 AMIN domain; Region: AMIN; pfam11741 82654006133 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 82654006134 Peptidase family M23; Region: Peptidase_M23; pfam01551 82654006135 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 82654006136 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 82654006137 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 82654006138 catalytic triad [active] 82654006139 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 82654006140 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 82654006141 active site 82654006142 catalytic tetrad [active] 82654006143 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 82654006144 RNB domain; Region: RNB; pfam00773 82654006145 GTPase Era; Reviewed; Region: era; PRK00089 82654006146 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 82654006147 G1 box; other site 82654006148 GTP/Mg2+ binding site [chemical binding]; other site 82654006149 Switch I region; other site 82654006150 G2 box; other site 82654006151 Switch II region; other site 82654006152 G3 box; other site 82654006153 G4 box; other site 82654006154 GTPase Era; Reviewed; Region: era; PRK00089 82654006155 KH domain; Region: KH_2; pfam07650 82654006156 G-X-X-G motif; other site 82654006157 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 82654006158 catalytic motif [active] 82654006159 Zn binding site [ion binding]; other site 82654006160 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 82654006161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654006162 dimer interface [polypeptide binding]; other site 82654006163 conserved gate region; other site 82654006164 putative PBP binding loops; other site 82654006165 ABC-ATPase subunit interface; other site 82654006166 tetratricopeptide repeat protein; Provisional; Region: PRK11788 82654006167 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 82654006168 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654006169 Walker A/P-loop; other site 82654006170 ATP binding site [chemical binding]; other site 82654006171 Q-loop/lid; other site 82654006172 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 82654006173 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 82654006174 ABC transporter signature motif; other site 82654006175 Walker B; other site 82654006176 D-loop; other site 82654006177 H-loop/switch region; other site 82654006178 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 82654006179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654006180 active site 82654006181 phosphorylation site [posttranslational modification] 82654006182 intermolecular recognition site; other site 82654006183 dimerization interface [polypeptide binding]; other site 82654006184 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 82654006185 DNA binding site [nucleotide binding] 82654006186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654006187 Response regulator receiver domain; Region: Response_reg; pfam00072 82654006188 active site 82654006189 phosphorylation site [posttranslational modification] 82654006190 intermolecular recognition site; other site 82654006191 dimerization interface [polypeptide binding]; other site 82654006192 Response regulator receiver domain; Region: Response_reg; pfam00072 82654006193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654006194 active site 82654006195 phosphorylation site [posttranslational modification] 82654006196 intermolecular recognition site; other site 82654006197 dimerization interface [polypeptide binding]; other site 82654006198 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 82654006199 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 82654006200 metal binding site [ion binding]; metal-binding site 82654006201 active site 82654006202 I-site; other site 82654006203 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 82654006204 anti sigma factor interaction site; other site 82654006205 regulatory phosphorylation site [posttranslational modification]; other site 82654006206 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 82654006207 Mechanosensitive ion channel; Region: MS_channel; pfam00924 82654006208 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 82654006209 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 82654006210 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 82654006211 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 82654006212 active site 82654006213 HIGH motif; other site 82654006214 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 82654006215 KMSKS motif; other site 82654006216 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 82654006217 tRNA binding surface [nucleotide binding]; other site 82654006218 anticodon binding site; other site 82654006219 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 82654006220 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 82654006221 Zn2+ binding site [ion binding]; other site 82654006222 Mg2+ binding site [ion binding]; other site 82654006223 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 82654006224 putative DNA binding site [nucleotide binding]; other site 82654006225 putative Zn2+ binding site [ion binding]; other site 82654006226 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 82654006227 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 82654006228 putative ABC transporter; Region: ycf24; CHL00085 82654006229 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 82654006230 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 82654006231 Walker A/P-loop; other site 82654006232 ATP binding site [chemical binding]; other site 82654006233 Q-loop/lid; other site 82654006234 ABC transporter signature motif; other site 82654006235 Walker B; other site 82654006236 D-loop; other site 82654006237 H-loop/switch region; other site 82654006238 FeS assembly protein SufD; Region: sufD; TIGR01981 82654006239 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 82654006240 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 82654006241 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 82654006242 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 82654006243 DXD motif; other site 82654006244 PilZ domain; Region: PilZ; pfam07238 82654006245 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 82654006246 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 82654006247 active site 82654006248 NTP binding site [chemical binding]; other site 82654006249 metal binding triad [ion binding]; metal-binding site 82654006250 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 82654006251 Peptidase family M50; Region: Peptidase_M50; pfam02163 82654006252 active site 82654006253 putative substrate binding region [chemical binding]; other site 82654006254 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 82654006255 Integrase core domain; Region: rve; pfam00665 82654006256 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 82654006257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654006258 Walker A motif; other site 82654006259 ATP binding site [chemical binding]; other site 82654006260 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 82654006261 Domain of unknown function DUF11; Region: DUF11; pfam01345 82654006262 sulfite reductase subunit beta; Provisional; Region: PRK13504 82654006263 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 82654006264 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 82654006265 cobalamin synthase; Reviewed; Region: cobS; PRK00235 82654006266 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654006267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654006268 active site 82654006269 phosphorylation site [posttranslational modification] 82654006270 intermolecular recognition site; other site 82654006271 dimerization interface [polypeptide binding]; other site 82654006272 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654006273 GAF domain; Region: GAF; pfam01590 82654006274 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654006275 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 82654006276 putative active site [active] 82654006277 heme pocket [chemical binding]; other site 82654006278 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654006279 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 82654006280 putative active site [active] 82654006281 heme pocket [chemical binding]; other site 82654006282 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654006283 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 82654006284 putative active site [active] 82654006285 heme pocket [chemical binding]; other site 82654006286 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654006287 putative active site [active] 82654006288 heme pocket [chemical binding]; other site 82654006289 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654006290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654006291 dimer interface [polypeptide binding]; other site 82654006292 phosphorylation site [posttranslational modification] 82654006293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654006294 ATP binding site [chemical binding]; other site 82654006295 Mg2+ binding site [ion binding]; other site 82654006296 G-X-G motif; other site 82654006297 Transcription initiation factor IIE, alpha subunit [Transcription]; Region: TFA1; COG1675 82654006298 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 82654006299 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654006300 active site 82654006301 ATP binding site [chemical binding]; other site 82654006302 substrate binding site [chemical binding]; other site 82654006303 activation loop (A-loop); other site 82654006304 Transposase IS200 like; Region: Y1_Tnp; pfam01797 82654006305 Dehydroquinase class II; Region: DHquinase_II; pfam01220 82654006306 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 82654006307 trimer interface [polypeptide binding]; other site 82654006308 active site 82654006309 dimer interface [polypeptide binding]; other site 82654006310 FeoA domain; Region: FeoA; pfam04023 82654006311 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 82654006312 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 82654006313 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 82654006314 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 82654006315 dimerization interface [polypeptide binding]; other site 82654006316 FAD binding pocket [chemical binding]; other site 82654006317 FAD binding motif [chemical binding]; other site 82654006318 catalytic residues [active] 82654006319 NAD binding pocket [chemical binding]; other site 82654006320 phosphate binding motif [ion binding]; other site 82654006321 beta-alpha-beta structure motif; other site 82654006322 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 82654006323 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 82654006324 PYR/PP interface [polypeptide binding]; other site 82654006325 dimer interface [polypeptide binding]; other site 82654006326 TPP binding site [chemical binding]; other site 82654006327 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 82654006328 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 82654006329 TPP-binding site [chemical binding]; other site 82654006330 dimer interface [polypeptide binding]; other site 82654006331 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 82654006332 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 82654006333 HSP70 interaction site [polypeptide binding]; other site 82654006334 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654006335 binding surface 82654006336 TPR motif; other site 82654006337 TPR repeat; Region: TPR_11; pfam13414 82654006338 TPR repeat; Region: TPR_11; pfam13414 82654006339 Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468 82654006340 photosystem II protein H; Region: psbH; CHL00066 82654006341 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 82654006342 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 82654006343 putative active site [active] 82654006344 catalytic residue [active] 82654006345 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 82654006346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654006347 Walker A/P-loop; other site 82654006348 ATP binding site [chemical binding]; other site 82654006349 Q-loop/lid; other site 82654006350 ABC transporter signature motif; other site 82654006351 Walker B; other site 82654006352 D-loop; other site 82654006353 H-loop/switch region; other site 82654006354 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 82654006355 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 82654006356 active site 82654006357 Substrate binding site; other site 82654006358 Mg++ binding site; other site 82654006359 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 82654006360 putative trimer interface [polypeptide binding]; other site 82654006361 putative CoA binding site [chemical binding]; other site 82654006362 Predicted membrane protein [Function unknown]; Region: COG4094 82654006363 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 82654006364 RibD C-terminal domain; Region: RibD_C; cl17279 82654006365 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 82654006366 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 82654006367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654006368 active site 82654006369 phosphorylation site [posttranslational modification] 82654006370 intermolecular recognition site; other site 82654006371 dimerization interface [polypeptide binding]; other site 82654006372 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 82654006373 DNA binding residues [nucleotide binding] 82654006374 dimerization interface [polypeptide binding]; other site 82654006375 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 82654006376 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 82654006377 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 82654006378 Switch I region; other site 82654006379 G3 box; other site 82654006380 Switch II region; other site 82654006381 G4 box; other site 82654006382 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374 82654006383 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 82654006384 active site 82654006385 PHP Thumb interface [polypeptide binding]; other site 82654006386 metal binding site [ion binding]; metal-binding site 82654006387 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 82654006388 generic binding surface II; other site 82654006389 generic binding surface I; other site 82654006390 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 82654006391 Phycobilisome protein; Region: Phycobilisome; cl08227 82654006392 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 82654006393 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654006394 Walker A/P-loop; other site 82654006395 ATP binding site [chemical binding]; other site 82654006396 Q-loop/lid; other site 82654006397 ABC transporter signature motif; other site 82654006398 Walker B; other site 82654006399 D-loop; other site 82654006400 H-loop/switch region; other site 82654006401 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 82654006402 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 82654006403 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 82654006404 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 82654006405 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 82654006406 anti sigma factor interaction site; other site 82654006407 regulatory phosphorylation site [posttranslational modification]; other site 82654006408 Response regulator receiver domain; Region: Response_reg; pfam00072 82654006409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654006410 active site 82654006411 phosphorylation site [posttranslational modification] 82654006412 intermolecular recognition site; other site 82654006413 dimerization interface [polypeptide binding]; other site 82654006414 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654006415 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 82654006416 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 82654006417 Ligand Binding Site [chemical binding]; other site 82654006418 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 82654006419 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 82654006420 Helix-turn-helix domain; Region: HTH_36; pfam13730 82654006421 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 82654006422 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 82654006423 putative substrate binding pocket [chemical binding]; other site 82654006424 dimer interface [polypeptide binding]; other site 82654006425 phosphate binding site [ion binding]; other site 82654006426 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 82654006427 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 82654006428 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 82654006429 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 82654006430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 82654006431 NAD(P) binding site [chemical binding]; other site 82654006432 active site 82654006433 diaminopimelate decarboxylase; Region: lysA; TIGR01048 82654006434 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 82654006435 active site 82654006436 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 82654006437 substrate binding site [chemical binding]; other site 82654006438 catalytic residues [active] 82654006439 dimer interface [polypeptide binding]; other site 82654006440 TIGR00159 family protein; Region: TIGR00159 82654006441 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 82654006442 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 82654006443 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 82654006444 catalytic residue [active] 82654006445 putative FPP diphosphate binding site; other site 82654006446 putative FPP binding hydrophobic cleft; other site 82654006447 dimer interface [polypeptide binding]; other site 82654006448 putative IPP diphosphate binding site; other site 82654006449 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 82654006450 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 82654006451 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 82654006452 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 82654006453 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 82654006454 DXD motif; other site 82654006455 Peptidase M16C associated; Region: M16C_assoc; pfam08367 82654006456 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 82654006457 ligand binding site [chemical binding]; other site 82654006458 flexible hinge region; other site 82654006459 DDE superfamily endonuclease; Region: DDE_3; pfam13358 82654006460 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 82654006461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654006462 Walker A motif; other site 82654006463 ATP binding site [chemical binding]; other site 82654006464 Integrase core domain; Region: rve; pfam00665 82654006465 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 82654006466 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 82654006467 dimer interface [polypeptide binding]; other site 82654006468 decamer (pentamer of dimers) interface [polypeptide binding]; other site 82654006469 catalytic triad [active] 82654006470 peroxidatic and resolving cysteines [active] 82654006471 Cupin domain; Region: Cupin_2; cl17218 82654006472 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 82654006473 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 82654006474 inhibitor-cofactor binding pocket; inhibition site 82654006475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 82654006476 catalytic residue [active] 82654006477 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 82654006478 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 82654006479 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 82654006480 putative active site [active] 82654006481 putative substrate binding site [chemical binding]; other site 82654006482 putative cosubstrate binding site; other site 82654006483 catalytic site [active] 82654006484 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 82654006485 FAD binding site [chemical binding]; other site 82654006486 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 82654006487 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 82654006488 homotrimer interaction site [polypeptide binding]; other site 82654006489 zinc binding site [ion binding]; other site 82654006490 CDP-binding sites; other site 82654006491 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654006492 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654006493 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654006494 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654006495 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654006496 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 82654006497 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 82654006498 ring oligomerisation interface [polypeptide binding]; other site 82654006499 ATP/Mg binding site [chemical binding]; other site 82654006500 stacking interactions; other site 82654006501 hinge regions; other site 82654006502 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 82654006503 oligomerisation interface [polypeptide binding]; other site 82654006504 mobile loop; other site 82654006505 roof hairpin; other site 82654006506 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654006507 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654006508 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654006509 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654006510 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654006511 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 82654006512 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 82654006513 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 82654006514 ligand binding site [chemical binding]; other site 82654006515 NAD binding site [chemical binding]; other site 82654006516 dimerization interface [polypeptide binding]; other site 82654006517 catalytic site [active] 82654006518 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 82654006519 putative L-serine binding site [chemical binding]; other site 82654006520 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 82654006521 PhoH-like protein; Region: PhoH; pfam02562 82654006522 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 82654006523 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; COG2082 82654006524 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 82654006525 DNA gyrase subunit A; Validated; Region: PRK05560 82654006526 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 82654006527 CAP-like domain; other site 82654006528 active site 82654006529 primary dimer interface [polypeptide binding]; other site 82654006530 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 82654006531 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 82654006532 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 82654006533 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 82654006534 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 82654006535 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 82654006536 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 82654006537 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 82654006538 dimer interface [polypeptide binding]; other site 82654006539 ADP-ribose binding site [chemical binding]; other site 82654006540 active site 82654006541 nudix motif; other site 82654006542 metal binding site [ion binding]; metal-binding site 82654006543 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654006544 binding surface 82654006545 Tetratricopeptide repeat; Region: TPR_12; pfam13424 82654006546 TPR motif; other site 82654006547 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 82654006548 cyclase homology domain; Region: CHD; cd07302 82654006549 nucleotidyl binding site; other site 82654006550 metal binding site [ion binding]; metal-binding site 82654006551 dimer interface [polypeptide binding]; other site 82654006552 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371 82654006553 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 82654006554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 82654006555 active site 82654006556 motif I; other site 82654006557 motif II; other site 82654006558 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 82654006559 anti sigma factor interaction site; other site 82654006560 regulatory phosphorylation site [posttranslational modification]; other site 82654006561 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 82654006562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654006563 ATP binding site [chemical binding]; other site 82654006564 Mg2+ binding site [ion binding]; other site 82654006565 G-X-G motif; other site 82654006566 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 82654006567 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 82654006568 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654006569 putative active site [active] 82654006570 Bacterial SH3 domain; Region: SH3_3; pfam08239 82654006571 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 82654006572 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 82654006573 active site 82654006574 metal binding site [ion binding]; metal-binding site 82654006575 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 82654006576 trimer interface [polypeptide binding]; other site 82654006577 active site 82654006578 substrate binding site [chemical binding]; other site 82654006579 CoA binding site [chemical binding]; other site 82654006580 acetyl-CoA synthetase; Provisional; Region: PRK00174 82654006581 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 82654006582 active site 82654006583 CoA binding site [chemical binding]; other site 82654006584 acyl-activating enzyme (AAE) consensus motif; other site 82654006585 AMP binding site [chemical binding]; other site 82654006586 acetate binding site [chemical binding]; other site 82654006587 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 82654006588 active site 82654006589 N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067 82654006590 Protein of unknown function, DUF608; Region: DUF608; pfam04685 82654006591 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 82654006592 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 82654006593 Inward rectifier potassium channel; Region: IRK; pfam01007 82654006594 CTP synthetase; Validated; Region: pyrG; PRK05380 82654006595 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 82654006596 Catalytic site [active] 82654006597 active site 82654006598 UTP binding site [chemical binding]; other site 82654006599 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 82654006600 active site 82654006601 putative oxyanion hole; other site 82654006602 catalytic triad [active] 82654006603 CHASE2 domain; Region: CHASE2; pfam05226 82654006604 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 82654006605 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 82654006606 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 82654006607 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 82654006608 GIY-YIG motif/motif A; other site 82654006609 active site 82654006610 catalytic site [active] 82654006611 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 82654006612 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 82654006613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 82654006614 NAD(P) binding site [chemical binding]; other site 82654006615 active site 82654006616 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 82654006617 substrate binding site [chemical binding]; other site 82654006618 active site 82654006619 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 82654006620 Cytochrome c; Region: Cytochrom_C; pfam00034 82654006621 FOG: WD40 repeat [General function prediction only]; Region: COG2319 82654006622 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 82654006623 structural tetrad; other site 82654006624 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 82654006625 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 82654006626 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 82654006627 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 82654006628 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 82654006629 S-layer homology domain; Region: SLH; pfam00395 82654006630 S-layer homology domain; Region: SLH; pfam00395 82654006631 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 82654006632 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 82654006633 metal binding site [ion binding]; metal-binding site 82654006634 Enolase C-terminal domain-like; Region: MR_MLE_C; pfam13378 82654006635 substrate binding pocket [chemical binding]; other site 82654006636 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 82654006637 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 82654006638 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 82654006639 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 82654006640 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 82654006641 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 82654006642 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 82654006643 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 82654006644 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 82654006645 P-loop, Walker A motif; other site 82654006646 Base recognition motif; other site 82654006647 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 82654006648 Uncharacterized conserved protein [Function unknown]; Region: COG1262 82654006649 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 82654006650 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 82654006651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654006652 Walker A motif; other site 82654006653 ATP binding site [chemical binding]; other site 82654006654 Walker B motif; other site 82654006655 arginine finger; other site 82654006656 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 82654006657 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 82654006658 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 82654006659 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 82654006660 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313 82654006661 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 82654006662 Phage protein D [General function prediction only]; Region: COG3500 82654006663 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 82654006664 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 82654006665 Uncharacterized conserved protein [Function unknown]; Region: COG4104 82654006666 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 82654006667 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 82654006668 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 82654006669 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 82654006670 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 82654006671 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 82654006672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 82654006673 Cupin domain; Region: Cupin_2; cl17218 82654006674 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 82654006675 Mif2/CENP-C like; Region: Mif2; pfam11699 82654006676 Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669 82654006677 oligomer interface [polypeptide binding]; other site 82654006678 Protein of unknown function (DUF98); Region: DUF98; pfam01947 82654006679 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 82654006680 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 82654006681 active site 82654006682 (T/H)XGH motif; other site 82654006683 AMIN domain; Region: AMIN; pfam11741 82654006684 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 82654006685 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 82654006686 active site 82654006687 metal binding site [ion binding]; metal-binding site 82654006688 glutamate racemase; Provisional; Region: PRK00865 82654006689 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 82654006690 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 82654006691 light-harvesting-like protein 3; Provisional; Region: PLN00014 82654006692 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 82654006693 homotrimer interaction site [polypeptide binding]; other site 82654006694 putative active site [active] 82654006695 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 82654006696 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 82654006697 NAD binding site [chemical binding]; other site 82654006698 homodimer interface [polypeptide binding]; other site 82654006699 active site 82654006700 substrate binding site [chemical binding]; other site 82654006701 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 82654006702 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 82654006703 active site 82654006704 interdomain interaction site; other site 82654006705 putative metal-binding site [ion binding]; other site 82654006706 nucleotide binding site [chemical binding]; other site 82654006707 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 82654006708 domain I; other site 82654006709 DNA binding groove [nucleotide binding] 82654006710 phosphate binding site [ion binding]; other site 82654006711 domain II; other site 82654006712 domain III; other site 82654006713 nucleotide binding site [chemical binding]; other site 82654006714 catalytic site [active] 82654006715 domain IV; other site 82654006716 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 82654006717 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 82654006718 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 82654006719 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 82654006720 glycogen branching enzyme; Provisional; Region: PRK05402 82654006721 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 82654006722 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 82654006723 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 82654006724 active site 82654006725 catalytic site [active] 82654006726 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 82654006727 TPR repeat; Region: TPR_11; pfam13414 82654006728 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654006729 binding surface 82654006730 TPR motif; other site 82654006731 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 82654006732 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654006733 active site 82654006734 ATP binding site [chemical binding]; other site 82654006735 substrate binding site [chemical binding]; other site 82654006736 activation loop (A-loop); other site 82654006737 TPR repeat; Region: TPR_11; pfam13414 82654006738 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654006739 TPR motif; other site 82654006740 binding surface 82654006741 TPR repeat; Region: TPR_11; pfam13414 82654006742 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654006743 binding surface 82654006744 TPR motif; other site 82654006745 TPR repeat; Region: TPR_11; pfam13414 82654006746 KWG Leptospira; Region: KWG; pfam07656 82654006747 KWG Leptospira; Region: KWG; pfam07656 82654006748 TPR repeat; Region: TPR_11; pfam13414 82654006749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654006750 binding surface 82654006751 TPR motif; other site 82654006752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654006753 binding surface 82654006754 TPR repeat; Region: TPR_11; pfam13414 82654006755 TPR motif; other site 82654006756 TPR repeat; Region: TPR_11; pfam13414 82654006757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654006758 binding surface 82654006759 TPR motif; other site 82654006760 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 82654006761 active site 82654006762 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 82654006763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 82654006764 Major Facilitator Superfamily; Region: MFS_1; pfam07690 82654006765 putative substrate translocation pore; other site 82654006766 TPR repeat; Region: TPR_11; pfam13414 82654006767 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654006768 binding surface 82654006769 TPR motif; other site 82654006770 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654006771 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 82654006772 TPR motif; other site 82654006773 binding surface 82654006774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654006775 binding surface 82654006776 TPR motif; other site 82654006777 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654006778 binding surface 82654006779 TPR motif; other site 82654006780 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 82654006781 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654006782 putative active site [active] 82654006783 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 82654006784 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 82654006785 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 82654006786 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 82654006787 elongation factor P; Validated; Region: PRK00529 82654006788 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 82654006789 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 82654006790 RNA binding site [nucleotide binding]; other site 82654006791 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 82654006792 RNA binding site [nucleotide binding]; other site 82654006793 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 82654006794 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 82654006795 carboxyltransferase (CT) interaction site; other site 82654006796 biotinylation site [posttranslational modification]; other site 82654006797 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 82654006798 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 82654006799 Response regulator receiver domain; Region: Response_reg; pfam00072 82654006800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654006801 active site 82654006802 phosphorylation site [posttranslational modification] 82654006803 intermolecular recognition site; other site 82654006804 dimerization interface [polypeptide binding]; other site 82654006805 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654006806 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654006807 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654006808 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654006809 dimer interface [polypeptide binding]; other site 82654006810 phosphorylation site [posttranslational modification] 82654006811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654006812 ATP binding site [chemical binding]; other site 82654006813 Mg2+ binding site [ion binding]; other site 82654006814 G-X-G motif; other site 82654006815 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654006816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654006817 active site 82654006818 phosphorylation site [posttranslational modification] 82654006819 intermolecular recognition site; other site 82654006820 dimerization interface [polypeptide binding]; other site 82654006821 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 82654006822 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654006823 Phytochrome region; Region: PHY; pfam00360 82654006824 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654006825 dimer interface [polypeptide binding]; other site 82654006826 phosphorylation site [posttranslational modification] 82654006827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654006828 ATP binding site [chemical binding]; other site 82654006829 Mg2+ binding site [ion binding]; other site 82654006830 G-X-G motif; other site 82654006831 ParA-like protein; Provisional; Region: PHA02518 82654006832 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 82654006833 P-loop; other site 82654006834 Magnesium ion binding site [ion binding]; other site 82654006835 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 82654006836 heterotetramer interface [polypeptide binding]; other site 82654006837 active site pocket [active] 82654006838 cleavage site 82654006839 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 82654006840 DNA photolyase; Region: DNA_photolyase; pfam00875 82654006841 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 82654006842 putative binding surface; other site 82654006843 active site 82654006844 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 82654006845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654006846 ATP binding site [chemical binding]; other site 82654006847 Mg2+ binding site [ion binding]; other site 82654006848 G-X-G motif; other site 82654006849 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 82654006850 Response regulator receiver domain; Region: Response_reg; pfam00072 82654006851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654006852 active site 82654006853 phosphorylation site [posttranslational modification] 82654006854 intermolecular recognition site; other site 82654006855 dimerization interface [polypeptide binding]; other site 82654006856 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 82654006857 dimerization interface [polypeptide binding]; other site 82654006858 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 82654006859 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 82654006860 dimer interface [polypeptide binding]; other site 82654006861 putative CheW interface [polypeptide binding]; other site 82654006862 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 82654006863 Response regulator receiver domain; Region: Response_reg; pfam00072 82654006864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654006865 active site 82654006866 phosphorylation site [posttranslational modification] 82654006867 intermolecular recognition site; other site 82654006868 dimerization interface [polypeptide binding]; other site 82654006869 Response regulator receiver domain; Region: Response_reg; pfam00072 82654006870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654006871 active site 82654006872 phosphorylation site [posttranslational modification] 82654006873 intermolecular recognition site; other site 82654006874 dimerization interface [polypeptide binding]; other site 82654006875 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654006876 putative active site [active] 82654006877 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 82654006878 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 82654006879 putative ligand binding site [chemical binding]; other site 82654006880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654006881 dimer interface [polypeptide binding]; other site 82654006882 phosphorylation site [posttranslational modification] 82654006883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654006884 ATP binding site [chemical binding]; other site 82654006885 Mg2+ binding site [ion binding]; other site 82654006886 G-X-G motif; other site 82654006887 FOG: WD40 repeat [General function prediction only]; Region: COG2319 82654006888 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 82654006889 structural tetrad; other site 82654006890 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 82654006891 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 82654006892 thymidylate kinase; Validated; Region: tmk; PRK00698 82654006893 TMP-binding site; other site 82654006894 ATP-binding site [chemical binding]; other site 82654006895 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 82654006896 putative hydrophobic ligand binding site [chemical binding]; other site 82654006897 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 82654006898 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 82654006899 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 82654006900 Sulfatase; Region: Sulfatase; pfam00884 82654006901 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 82654006902 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 82654006903 active site 82654006904 catalytic triad [active] 82654006905 oxyanion hole [active] 82654006906 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 82654006907 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 82654006908 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 82654006909 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 82654006910 AAA-like domain; Region: AAA_10; pfam12846 82654006911 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 82654006912 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 82654006913 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 82654006914 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654006915 active site 82654006916 ATP binding site [chemical binding]; other site 82654006917 substrate binding site [chemical binding]; other site 82654006918 activation loop (A-loop); other site 82654006919 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 82654006920 Domain of unknown function DUF20; Region: UPF0118; pfam01594 82654006921 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 82654006922 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 82654006923 GIY-YIG motif/motif A; other site 82654006924 active site 82654006925 catalytic site [active] 82654006926 putative DNA binding site [nucleotide binding]; other site 82654006927 metal binding site [ion binding]; metal-binding site 82654006928 UvrB/uvrC motif; Region: UVR; pfam02151 82654006929 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 82654006930 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 82654006931 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 82654006932 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 82654006933 protein binding site [polypeptide binding]; other site 82654006934 MarC family integral membrane protein; Region: MarC; pfam01914 82654006935 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 82654006936 active site 82654006937 bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424 82654006938 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 82654006939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 82654006940 NAD(P) binding site [chemical binding]; other site 82654006941 hypothetical protein; Provisional; Region: PRK13683 82654006942 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 82654006943 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 82654006944 Walker A/P-loop; other site 82654006945 ATP binding site [chemical binding]; other site 82654006946 Q-loop/lid; other site 82654006947 ABC transporter signature motif; other site 82654006948 Walker B; other site 82654006949 D-loop; other site 82654006950 H-loop/switch region; other site 82654006951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 82654006952 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 82654006953 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654006954 Walker A motif; other site 82654006955 ATP binding site [chemical binding]; other site 82654006956 Walker B motif; other site 82654006957 arginine finger; other site 82654006958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654006959 Walker A motif; other site 82654006960 ATP binding site [chemical binding]; other site 82654006961 Walker B motif; other site 82654006962 arginine finger; other site 82654006963 Protein phosphatase 2C; Region: PP2C_2; pfam13672 82654006964 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 82654006965 metal ion-dependent adhesion site (MIDAS); other site 82654006966 TPR repeat; Region: TPR_11; pfam13414 82654006967 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654006968 binding surface 82654006969 TPR motif; other site 82654006970 TPR repeat; Region: TPR_11; pfam13414 82654006971 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654006972 TPR motif; other site 82654006973 binding surface 82654006974 TPR repeat; Region: TPR_11; pfam13414 82654006975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654006976 binding surface 82654006977 TPR motif; other site 82654006978 Tetratricopeptide repeat; Region: TPR_12; pfam13424 82654006979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654006980 binding surface 82654006981 TPR motif; other site 82654006982 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 82654006983 active site 82654006984 multimer interface [polypeptide binding]; other site 82654006985 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 82654006986 protein I interface; other site 82654006987 D2 interface; other site 82654006988 protein T interface; other site 82654006989 chlorophyll binding site; other site 82654006990 beta carotene binding site; other site 82654006991 pheophytin binding site; other site 82654006992 manganese-stabilizing polypeptide interface; other site 82654006993 CP43 interface; other site 82654006994 protein L interface; other site 82654006995 oxygen evolving complex binding site; other site 82654006996 bromide binding site; other site 82654006997 quinone binding site; other site 82654006998 Fe binding site [ion binding]; other site 82654006999 core light harvesting interface; other site 82654007000 cytochrome b559 alpha subunit interface; other site 82654007001 cytochrome c-550 interface; other site 82654007002 protein J interface; other site 82654007003 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 82654007004 Low molecular weight phosphatase family; Region: LMWPc; cd00115 82654007005 active site 82654007006 pyruvate kinase; Provisional; Region: PRK06354 82654007007 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 82654007008 domain interfaces; other site 82654007009 active site 82654007010 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 82654007011 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 82654007012 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 82654007013 catalytic loop [active] 82654007014 iron binding site [ion binding]; other site 82654007015 cyclase homology domain; Region: CHD; cd07302 82654007016 nucleotidyl binding site; other site 82654007017 metal binding site [ion binding]; metal-binding site 82654007018 dimer interface [polypeptide binding]; other site 82654007019 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 82654007020 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 82654007021 Ycf39; Provisional; Region: ycf39; CHL00194 82654007022 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 82654007023 NAD(P) binding site [chemical binding]; other site 82654007024 putative active site [active] 82654007025 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 82654007026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654007027 dimer interface [polypeptide binding]; other site 82654007028 conserved gate region; other site 82654007029 ABC-ATPase subunit interface; other site 82654007030 HEAT repeats; Region: HEAT_2; pfam13646 82654007031 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 82654007032 Sporulation related domain; Region: SPOR; pfam05036 82654007033 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 82654007034 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 82654007035 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 82654007036 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 82654007037 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 82654007038 Mechanosensitive ion channel; Region: MS_channel; pfam00924 82654007039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654007040 dimer interface [polypeptide binding]; other site 82654007041 phosphorylation site [posttranslational modification] 82654007042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654007043 ATP binding site [chemical binding]; other site 82654007044 Mg2+ binding site [ion binding]; other site 82654007045 G-X-G motif; other site 82654007046 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654007047 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 82654007048 putative active site [active] 82654007049 heme pocket [chemical binding]; other site 82654007050 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654007051 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 82654007052 putative active site [active] 82654007053 heme pocket [chemical binding]; other site 82654007054 PAS domain S-box; Region: sensory_box; TIGR00229 82654007055 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654007056 putative active site [active] 82654007057 heme pocket [chemical binding]; other site 82654007058 PAS domain S-box; Region: sensory_box; TIGR00229 82654007059 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654007060 putative active site [active] 82654007061 heme pocket [chemical binding]; other site 82654007062 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654007063 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654007064 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654007065 dimer interface [polypeptide binding]; other site 82654007066 phosphorylation site [posttranslational modification] 82654007067 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 82654007068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654007069 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654007070 ATP binding site [chemical binding]; other site 82654007071 G-X-G motif; other site 82654007072 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654007073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654007074 active site 82654007075 phosphorylation site [posttranslational modification] 82654007076 intermolecular recognition site; other site 82654007077 dimerization interface [polypeptide binding]; other site 82654007078 Response regulator receiver domain; Region: Response_reg; pfam00072 82654007079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654007080 active site 82654007081 phosphorylation site [posttranslational modification] 82654007082 intermolecular recognition site; other site 82654007083 dimerization interface [polypeptide binding]; other site 82654007084 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 82654007085 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 82654007086 oligomer interface [polypeptide binding]; other site 82654007087 metal binding site [ion binding]; metal-binding site 82654007088 metal binding site [ion binding]; metal-binding site 82654007089 Cl binding site [ion binding]; other site 82654007090 aspartate ring; other site 82654007091 basic sphincter; other site 82654007092 putative hydrophobic gate; other site 82654007093 periplasmic entrance; other site 82654007094 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 82654007095 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 82654007096 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 82654007097 NAD(P) binding site [chemical binding]; other site 82654007098 putative phosphoketolase; Provisional; Region: PRK05261 82654007099 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 82654007100 TPP-binding site; other site 82654007101 XFP C-terminal domain; Region: XFP_C; pfam09363 82654007102 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 82654007103 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 82654007104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654007105 dimer interface [polypeptide binding]; other site 82654007106 conserved gate region; other site 82654007107 putative PBP binding loops; other site 82654007108 ABC-ATPase subunit interface; other site 82654007109 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 82654007110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654007111 putative PBP binding loops; other site 82654007112 dimer interface [polypeptide binding]; other site 82654007113 ABC-ATPase subunit interface; other site 82654007114 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 82654007115 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 82654007116 Walker A/P-loop; other site 82654007117 ATP binding site [chemical binding]; other site 82654007118 Q-loop/lid; other site 82654007119 ABC transporter signature motif; other site 82654007120 Walker B; other site 82654007121 D-loop; other site 82654007122 H-loop/switch region; other site 82654007123 TOBE domain; Region: TOBE_2; pfam08402 82654007124 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 82654007125 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 82654007126 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 82654007127 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 82654007128 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 82654007129 motif II; other site 82654007130 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 82654007131 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 82654007132 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 82654007133 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 82654007134 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 82654007135 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 82654007136 active site 82654007137 SAM binding site [chemical binding]; other site 82654007138 homodimer interface [polypeptide binding]; other site 82654007139 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654007140 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007141 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007142 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007143 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007144 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654007145 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007146 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007147 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007148 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007149 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654007150 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007151 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654007152 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007153 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007154 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 82654007155 putative nucleotide binding site [chemical binding]; other site 82654007156 uridine monophosphate binding site [chemical binding]; other site 82654007157 homohexameric interface [polypeptide binding]; other site 82654007158 ribosome recycling factor; Reviewed; Region: frr; PRK00083 82654007159 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 82654007160 hinge region; other site 82654007161 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 82654007162 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 82654007163 Biliverdin reductase, catalytic; Region: Biliv-reduc_cat; pfam09166 82654007164 homoserine kinase; Provisional; Region: PRK01212 82654007165 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 82654007166 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 82654007167 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 82654007168 dimer interface [polypeptide binding]; other site 82654007169 active site 82654007170 metal binding site [ion binding]; metal-binding site 82654007171 glutathione binding site [chemical binding]; other site 82654007172 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 82654007173 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 82654007174 NAD(P) binding site [chemical binding]; other site 82654007175 catalytic residues [active] 82654007176 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 82654007177 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 82654007178 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 82654007179 CoA binding site [chemical binding]; other site 82654007180 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 82654007181 catalytic residues [active] 82654007182 Int/Topo IB signature motif; other site 82654007183 DNA binding site [nucleotide binding] 82654007184 Fatty acid desaturase; Region: FA_desaturase; pfam00487 82654007185 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 82654007186 Di-iron ligands [ion binding]; other site 82654007187 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 82654007188 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 82654007189 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 82654007190 Coenzyme A binding pocket [chemical binding]; other site 82654007191 GUN4-like; Region: GUN4; pfam05419 82654007192 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 82654007193 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 82654007194 active site 82654007195 iron coordination sites [ion binding]; other site 82654007196 substrate binding pocket [chemical binding]; other site 82654007197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 82654007198 Major Facilitator Superfamily; Region: MFS_1; pfam07690 82654007199 putative substrate translocation pore; other site 82654007200 hypothetical protein; Provisional; Region: PRK01184 82654007201 Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_HCS; cd07948 82654007202 homocitrate synthase; Region: LysS_fung_arch; TIGR02146 82654007203 active site 82654007204 catalytic residues [active] 82654007205 metal binding site [ion binding]; metal-binding site 82654007206 Transmembrane proteins 14C; Region: Tmemb_14; cl02346 82654007207 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 82654007208 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 82654007209 Peptidase family M23; Region: Peptidase_M23; pfam01551 82654007210 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 82654007211 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 82654007212 active site 82654007213 dimerization interface [polypeptide binding]; other site 82654007214 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 82654007215 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 82654007216 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 82654007217 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 82654007218 rod shape-determining protein MreC; Provisional; Region: PRK13922 82654007219 rod shape-determining protein MreC; Region: MreC; pfam04085 82654007220 rod shape-determining protein MreB; Provisional; Region: PRK13927 82654007221 MreB and similar proteins; Region: MreB_like; cd10225 82654007222 nucleotide binding site [chemical binding]; other site 82654007223 Mg binding site [ion binding]; other site 82654007224 putative protofilament interaction site [polypeptide binding]; other site 82654007225 RodZ interaction site [polypeptide binding]; other site 82654007226 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 82654007227 putative hydrophobic ligand binding site [chemical binding]; other site 82654007228 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 82654007229 active site 82654007230 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 82654007231 dimerization interface [polypeptide binding]; other site 82654007232 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 82654007233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654007234 dimer interface [polypeptide binding]; other site 82654007235 phosphorylation site [posttranslational modification] 82654007236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654007237 ATP binding site [chemical binding]; other site 82654007238 Mg2+ binding site [ion binding]; other site 82654007239 G-X-G motif; other site 82654007240 PetN; Region: PetN; pfam03742 82654007241 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 82654007242 ligand binding site; other site 82654007243 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654007244 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 82654007245 Walker A/P-loop; other site 82654007246 ATP binding site [chemical binding]; other site 82654007247 Q-loop/lid; other site 82654007248 ABC transporter signature motif; other site 82654007249 Walker B; other site 82654007250 D-loop; other site 82654007251 H-loop/switch region; other site 82654007252 Response regulator receiver domain; Region: Response_reg; pfam00072 82654007253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654007254 active site 82654007255 phosphorylation site [posttranslational modification] 82654007256 intermolecular recognition site; other site 82654007257 dimerization interface [polypeptide binding]; other site 82654007258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654007259 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654007260 dimer interface [polypeptide binding]; other site 82654007261 phosphorylation site [posttranslational modification] 82654007262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654007263 ATP binding site [chemical binding]; other site 82654007264 Mg2+ binding site [ion binding]; other site 82654007265 G-X-G motif; other site 82654007266 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 82654007267 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 82654007268 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 82654007269 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 82654007270 P-loop; other site 82654007271 Magnesium ion binding site [ion binding]; other site 82654007272 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 82654007273 Magnesium ion binding site [ion binding]; other site 82654007274 Cache domain; Region: Cache_1; pfam02743 82654007275 PAS domain S-box; Region: sensory_box; TIGR00229 82654007276 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654007277 putative active site [active] 82654007278 heme pocket [chemical binding]; other site 82654007279 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654007280 dimer interface [polypeptide binding]; other site 82654007281 phosphorylation site [posttranslational modification] 82654007282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654007283 ATP binding site [chemical binding]; other site 82654007284 Mg2+ binding site [ion binding]; other site 82654007285 G-X-G motif; other site 82654007286 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654007287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654007288 active site 82654007289 phosphorylation site [posttranslational modification] 82654007290 intermolecular recognition site; other site 82654007291 dimerization interface [polypeptide binding]; other site 82654007292 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 82654007293 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 82654007294 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 82654007295 hinge; other site 82654007296 active site 82654007297 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 82654007298 catalytic center binding site [active] 82654007299 ATP binding site [chemical binding]; other site 82654007300 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 82654007301 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 82654007302 dimerization interface [polypeptide binding]; other site 82654007303 active site 82654007304 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 82654007305 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 82654007306 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 82654007307 MoxR-like ATPases [General function prediction only]; Region: COG0714 82654007308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654007309 ATP binding site [chemical binding]; other site 82654007310 Walker A motif; other site 82654007311 Walker B motif; other site 82654007312 arginine finger; other site 82654007313 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 82654007314 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 82654007315 active site 82654007316 Riboflavin kinase; Region: Flavokinase; smart00904 82654007317 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 82654007318 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 82654007319 5S rRNA interface [nucleotide binding]; other site 82654007320 CTC domain interface [polypeptide binding]; other site 82654007321 L16 interface [polypeptide binding]; other site 82654007322 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 82654007323 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 82654007324 GDP-binding site [chemical binding]; other site 82654007325 ACT binding site; other site 82654007326 IMP binding site; other site 82654007327 RDD family; Region: RDD; pfam06271 82654007328 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 82654007329 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 82654007330 PBP superfamily domain; Region: PBP_like_2; cl17296 82654007331 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 82654007332 Predicted transporter component [General function prediction only]; Region: COG2391 82654007333 Sulphur transport; Region: Sulf_transp; pfam04143 82654007334 Domain of unknown function (DUF309); Region: DUF309; pfam03745 82654007335 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 82654007336 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 82654007337 active site 82654007338 metal binding site [ion binding]; metal-binding site 82654007339 nudix motif; other site 82654007340 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 82654007341 NAD(P) binding site [chemical binding]; other site 82654007342 catalytic residues [active] 82654007343 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 82654007344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 82654007345 Coenzyme A binding pocket [chemical binding]; other site 82654007346 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 82654007347 Domain of unknown function DUF20; Region: UPF0118; pfam01594 82654007348 M28 Zn-Peptidases; Region: M28_like_1; cd05640 82654007349 Peptidase family M28; Region: Peptidase_M28; pfam04389 82654007350 metal binding site [ion binding]; metal-binding site 82654007351 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 82654007352 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 82654007353 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 82654007354 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 82654007355 TPR repeat; Region: TPR_11; pfam13414 82654007356 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654007357 binding surface 82654007358 TPR motif; other site 82654007359 TPR repeat; Region: TPR_11; pfam13414 82654007360 TPR repeat; Region: TPR_11; pfam13414 82654007361 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654007362 binding surface 82654007363 TPR motif; other site 82654007364 TPR repeat; Region: TPR_11; pfam13414 82654007365 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654007366 binding surface 82654007367 TPR motif; other site 82654007368 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 82654007369 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 82654007370 catalytic residue [active] 82654007371 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654007372 putative active site [active] 82654007373 Domain of unknown function (DUF1971); Region: DUF1971; pfam09313 82654007374 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 82654007375 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 82654007376 MAPEG family; Region: MAPEG; cl09190 82654007377 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 82654007378 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 82654007379 putative NAD(P) binding site [chemical binding]; other site 82654007380 active site 82654007381 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654007382 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007383 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007384 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007385 protoporphyrinogen oxidase; Region: PLN02576 82654007386 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 82654007387 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 82654007388 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 82654007389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654007390 S-adenosylmethionine binding site [chemical binding]; other site 82654007391 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 82654007392 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 82654007393 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 82654007394 catalytic triad [active] 82654007395 ribosomal protein L32; Validated; Region: rpl32; CHL00152 82654007396 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; pfam05430 82654007397 ATP synthase I chain; Region: ATP_synt_I; pfam03899 82654007398 ATP synthase CF0 A subunit; Region: atpI; CHL00046 82654007399 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 82654007400 ATP synthase CF0 C subunit; Region: atpH; CHL00061 82654007401 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 82654007402 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 82654007403 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 82654007404 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 82654007405 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 82654007406 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 82654007407 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 82654007408 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 82654007409 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 82654007410 beta subunit interaction interface [polypeptide binding]; other site 82654007411 Walker A motif; other site 82654007412 ATP binding site [chemical binding]; other site 82654007413 Walker B motif; other site 82654007414 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 82654007415 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 82654007416 tandem repeat interface [polypeptide binding]; other site 82654007417 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 82654007418 oligomer interface [polypeptide binding]; other site 82654007419 active site residues [active] 82654007420 Integrase core domain; Region: rve; pfam00665 82654007421 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 82654007422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654007423 Walker A motif; other site 82654007424 ATP binding site [chemical binding]; other site 82654007425 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007426 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654007427 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007428 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007429 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007430 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007431 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007432 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 82654007434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 82654007435 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 82654007436 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 82654007437 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654007438 TPR motif; other site 82654007439 binding surface 82654007440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654007441 binding surface 82654007442 TPR motif; other site 82654007443 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654007444 binding surface 82654007445 TPR motif; other site 82654007446 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 82654007447 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 82654007448 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 82654007449 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 82654007450 hinge; other site 82654007451 active site 82654007452 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 82654007453 nucleotide binding site [chemical binding]; other site 82654007454 putative NEF/HSP70 interaction site [polypeptide binding]; other site 82654007455 SBD interface [polypeptide binding]; other site 82654007456 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 82654007457 metal ion-dependent adhesion site (MIDAS); other site 82654007458 Transglycosylase; Region: Transgly; pfam00912 82654007459 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 82654007460 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 82654007461 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 82654007462 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 82654007463 active site 82654007464 HIGH motif; other site 82654007465 dimer interface [polypeptide binding]; other site 82654007466 KMSKS motif; other site 82654007467 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 82654007468 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 82654007469 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 82654007470 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 82654007471 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 82654007472 active site 82654007473 TIR domain; Region: TIR_2; pfam13676 82654007474 Uncharacterized conserved protein [Function unknown]; Region: COG1262 82654007475 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 82654007476 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 82654007477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654007478 active site 82654007479 phosphorylation site [posttranslational modification] 82654007480 intermolecular recognition site; other site 82654007481 dimerization interface [polypeptide binding]; other site 82654007482 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 82654007483 DNA binding residues [nucleotide binding] 82654007484 dimerization interface [polypeptide binding]; other site 82654007485 Transcriptional regulator [Transcription]; Region: LytR; COG1316 82654007486 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 82654007487 Animal haem peroxidase; Region: An_peroxidase; pfam03098 82654007488 heme binding site [chemical binding]; other site 82654007489 substrate binding site [chemical binding]; other site 82654007490 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 82654007491 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 82654007492 Bacterial sugar transferase; Region: Bac_transf; pfam02397 82654007493 DNA polymerase III subunit delta; Validated; Region: PRK07452 82654007494 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 82654007495 dihydroorotase; Provisional; Region: PRK07369 82654007496 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 82654007497 active site 82654007498 ribosomal protein S20; Region: rps20; CHL00102 82654007499 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 82654007500 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 82654007501 Nucleoside recognition; Region: Gate; pfam07670 82654007502 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 82654007503 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 82654007504 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 82654007505 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 82654007506 TIGR04255 family protein; Region: sporadTIGR04255 82654007507 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 82654007508 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 82654007509 GTP binding site; other site 82654007510 hypothetical protein; Provisional; Region: PRK07394 82654007511 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 82654007512 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 82654007513 Transcriptional regulator [Transcription]; Region: LysR; COG0583 82654007514 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 82654007515 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 82654007516 dimerization interface [polypeptide binding]; other site 82654007517 HEAT repeats; Region: HEAT_2; pfam13646 82654007518 HEAT repeats; Region: HEAT_2; pfam13646 82654007519 HEAT repeats; Region: HEAT_2; pfam13646 82654007520 HEAT repeats; Region: HEAT_2; pfam13646 82654007521 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 82654007522 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 82654007523 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 82654007524 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 82654007525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654007526 dimer interface [polypeptide binding]; other site 82654007527 conserved gate region; other site 82654007528 putative PBP binding loops; other site 82654007529 ABC-ATPase subunit interface; other site 82654007530 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 82654007531 NMT1-like family; Region: NMT1_2; pfam13379 82654007532 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 82654007533 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 82654007534 Walker A/P-loop; other site 82654007535 ATP binding site [chemical binding]; other site 82654007536 Q-loop/lid; other site 82654007537 ABC transporter signature motif; other site 82654007538 Walker B; other site 82654007539 D-loop; other site 82654007540 H-loop/switch region; other site 82654007541 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 82654007542 NMT1-like family; Region: NMT1_2; pfam13379 82654007543 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 82654007544 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 82654007545 Walker A/P-loop; other site 82654007546 ATP binding site [chemical binding]; other site 82654007547 Q-loop/lid; other site 82654007548 ABC transporter signature motif; other site 82654007549 Walker B; other site 82654007550 D-loop; other site 82654007551 H-loop/switch region; other site 82654007552 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 82654007553 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 82654007554 [4Fe-4S] binding site [ion binding]; other site 82654007555 molybdopterin cofactor binding site; other site 82654007556 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 82654007557 molybdopterin cofactor binding site; other site 82654007558 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 82654007559 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 82654007560 seryl-tRNA synthetase; Provisional; Region: PRK05431 82654007561 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 82654007562 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 82654007563 dimer interface [polypeptide binding]; other site 82654007564 active site 82654007565 motif 1; other site 82654007566 motif 2; other site 82654007567 motif 3; other site 82654007568 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 82654007569 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 82654007570 nucleotide binding site [chemical binding]; other site 82654007571 Protein of unknown function (DUF448); Region: DUF448; pfam04296 82654007572 putative RNA binding cleft [nucleotide binding]; other site 82654007573 DEAD-like helicases superfamily; Region: DEXDc; smart00487 82654007574 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 82654007575 ATP binding site [chemical binding]; other site 82654007576 putative Mg++ binding site [ion binding]; other site 82654007577 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 82654007578 nucleotide binding region [chemical binding]; other site 82654007579 ATP-binding site [chemical binding]; other site 82654007580 FOG: WD40 repeat [General function prediction only]; Region: COG2319 82654007581 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 82654007582 structural tetrad; other site 82654007583 Response regulator receiver domain; Region: Response_reg; pfam00072 82654007584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654007585 active site 82654007586 phosphorylation site [posttranslational modification] 82654007587 intermolecular recognition site; other site 82654007588 dimerization interface [polypeptide binding]; other site 82654007589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654007590 Response regulator receiver domain; Region: Response_reg; pfam00072 82654007591 active site 82654007592 phosphorylation site [posttranslational modification] 82654007593 intermolecular recognition site; other site 82654007594 dimerization interface [polypeptide binding]; other site 82654007595 CheW-like domain; Region: CheW; pfam01584 82654007596 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 82654007597 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 82654007598 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 82654007599 dimer interface [polypeptide binding]; other site 82654007600 putative CheW interface [polypeptide binding]; other site 82654007601 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 82654007602 dimerization interface [polypeptide binding]; other site 82654007603 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 82654007604 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 82654007605 dimer interface [polypeptide binding]; other site 82654007606 putative CheW interface [polypeptide binding]; other site 82654007607 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 82654007608 putative binding surface; other site 82654007609 active site 82654007610 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 82654007611 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 82654007612 putative binding surface; other site 82654007613 active site 82654007614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654007615 ATP binding site [chemical binding]; other site 82654007616 Mg2+ binding site [ion binding]; other site 82654007617 G-X-G motif; other site 82654007618 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 82654007619 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654007620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654007621 active site 82654007622 phosphorylation site [posttranslational modification] 82654007623 intermolecular recognition site; other site 82654007624 dimerization interface [polypeptide binding]; other site 82654007625 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 82654007626 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 82654007627 FeS/SAM binding site; other site 82654007628 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 82654007629 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 82654007630 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 82654007631 catalytic triad [active] 82654007632 dimer interface [polypeptide binding]; other site 82654007633 RloB-like protein; Region: RloB; pfam13707 82654007634 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654007635 AAA domain; Region: AAA_21; pfam13304 82654007636 Walker A/P-loop; other site 82654007637 ATP binding site [chemical binding]; other site 82654007638 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 82654007639 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 82654007640 active site 82654007641 metal binding site [ion binding]; metal-binding site 82654007642 Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378 82654007643 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 82654007644 active site 82654007645 metal binding site [ion binding]; metal-binding site 82654007646 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 82654007647 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 82654007648 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007649 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654007650 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007651 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007652 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 82654007653 putative catalytic residues [active] 82654007654 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 82654007655 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 82654007656 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 82654007657 ATP binding site [chemical binding]; other site 82654007658 putative Mg++ binding site [ion binding]; other site 82654007659 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 82654007660 nucleotide binding region [chemical binding]; other site 82654007661 ATP-binding site [chemical binding]; other site 82654007662 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 82654007663 TPR repeat; Region: TPR_11; pfam13414 82654007664 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654007665 TPR motif; other site 82654007666 Tetratricopeptide repeat; Region: TPR_12; pfam13424 82654007667 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654007668 TPR repeat; Region: TPR_11; pfam13414 82654007669 binding surface 82654007670 TPR motif; other site 82654007671 GUN4-like; Region: GUN4; pfam05419 82654007672 HEAT repeats; Region: HEAT_2; pfam13646 82654007673 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 82654007674 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 82654007675 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 82654007676 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 82654007677 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 82654007678 HSP70 interaction site [polypeptide binding]; other site 82654007679 TPR repeat; Region: TPR_11; pfam13414 82654007680 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 82654007681 TPR repeat; Region: TPR_11; pfam13414 82654007682 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654007683 binding surface 82654007684 TPR motif; other site 82654007685 TPR repeat; Region: TPR_11; pfam13414 82654007686 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654007687 binding surface 82654007688 TPR motif; other site 82654007689 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 82654007690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654007691 TPR motif; other site 82654007692 binding surface 82654007693 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654007694 binding surface 82654007695 TPR motif; other site 82654007696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654007697 binding surface 82654007698 TPR motif; other site 82654007699 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 82654007700 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654007701 TPR motif; other site 82654007702 TPR repeat; Region: TPR_11; pfam13414 82654007703 binding surface 82654007704 TPR repeat; Region: TPR_11; pfam13414 82654007705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654007706 binding surface 82654007707 TPR motif; other site 82654007708 TPR repeat; Region: TPR_11; pfam13414 82654007709 TPR repeat; Region: TPR_11; pfam13414 82654007710 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 82654007711 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654007712 binding surface 82654007713 TPR motif; other site 82654007714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654007715 binding surface 82654007716 TPR motif; other site 82654007717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654007718 binding surface 82654007719 TPR motif; other site 82654007720 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654007721 binding surface 82654007722 TPR motif; other site 82654007723 Tetratricopeptide repeat; Region: TPR_12; pfam13424 82654007724 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654007725 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 82654007726 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 82654007727 oligomerisation interface [polypeptide binding]; other site 82654007728 mobile loop; other site 82654007729 roof hairpin; other site 82654007730 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 82654007731 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 82654007732 ring oligomerisation interface [polypeptide binding]; other site 82654007733 ATP/Mg binding site [chemical binding]; other site 82654007734 stacking interactions; other site 82654007735 hinge regions; other site 82654007736 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 82654007737 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 82654007738 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 82654007739 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 82654007740 cytochrome c-550; Provisional; Region: psbV; cl17239 82654007741 plastocyanin; Provisional; Region: PRK02710 82654007742 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 82654007743 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 82654007744 active site 1 [active] 82654007745 dimer interface [polypeptide binding]; other site 82654007746 hexamer interface [polypeptide binding]; other site 82654007747 active site 2 [active] 82654007748 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654007749 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007750 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007751 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654007752 GAF domain; Region: GAF; pfam01590 82654007753 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654007754 GAF domain; Region: GAF; pfam01590 82654007755 GAF domain; Region: GAF_3; pfam13492 82654007756 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654007757 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 82654007758 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 82654007759 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 82654007760 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 82654007761 ligand binding site [chemical binding]; other site 82654007762 flexible hinge region; other site 82654007763 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 82654007764 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 82654007765 putative catalytic cysteine [active] 82654007766 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 82654007767 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 82654007768 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654007769 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007770 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007771 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007772 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007773 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007774 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 82654007775 putative hexamer interface [polypeptide binding]; other site 82654007776 putative hexagonal pore; other site 82654007777 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 82654007778 Hexamer interface [polypeptide binding]; other site 82654007779 Hexagonal pore residue; other site 82654007780 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 82654007781 FMN binding site [chemical binding]; other site 82654007782 dimer interface [polypeptide binding]; other site 82654007783 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 82654007784 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 82654007785 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654007786 Walker A motif; other site 82654007787 ATP binding site [chemical binding]; other site 82654007788 Walker B motif; other site 82654007789 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 82654007790 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 82654007791 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 82654007792 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 82654007793 Uncharacterized conserved protein [Function unknown]; Region: COG1262 82654007794 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 82654007795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 82654007796 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 82654007797 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654007798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654007799 active site 82654007800 phosphorylation site [posttranslational modification] 82654007801 intermolecular recognition site; other site 82654007802 dimerization interface [polypeptide binding]; other site 82654007803 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 82654007804 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 82654007805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654007806 S-adenosylmethionine binding site [chemical binding]; other site 82654007807 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 82654007808 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 82654007809 active site 82654007810 homodimer interface [polypeptide binding]; other site 82654007811 catalytic site [active] 82654007812 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654007813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654007814 ATP binding site [chemical binding]; other site 82654007815 Mg2+ binding site [ion binding]; other site 82654007816 G-X-G motif; other site 82654007817 NAD synthetase; Provisional; Region: PRK13981 82654007818 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 82654007819 multimer interface [polypeptide binding]; other site 82654007820 active site 82654007821 catalytic triad [active] 82654007822 protein interface 1 [polypeptide binding]; other site 82654007823 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 82654007824 homodimer interface [polypeptide binding]; other site 82654007825 NAD binding pocket [chemical binding]; other site 82654007826 ATP binding pocket [chemical binding]; other site 82654007827 Mg binding site [ion binding]; other site 82654007828 active-site loop [active] 82654007829 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 82654007830 nudix motif; other site 82654007831 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 82654007832 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 82654007833 active site 82654007834 (T/H)XGH motif; other site 82654007835 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 82654007836 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 82654007837 active site 82654007838 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 82654007839 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 82654007840 active site 82654007841 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 82654007842 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 82654007843 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 82654007844 active site 82654007845 catalytic site [active] 82654007846 MutS domain III; Region: MutS_III; pfam05192 82654007847 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 82654007848 Walker A/P-loop; other site 82654007849 ATP binding site [chemical binding]; other site 82654007850 Q-loop/lid; other site 82654007851 ABC transporter signature motif; other site 82654007852 Walker B; other site 82654007853 D-loop; other site 82654007854 H-loop/switch region; other site 82654007855 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 82654007856 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 82654007857 putative DNA binding site [nucleotide binding]; other site 82654007858 putative Zn2+ binding site [ion binding]; other site 82654007859 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 82654007860 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 82654007861 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 82654007862 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 82654007863 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 82654007864 RNA binding surface [nucleotide binding]; other site 82654007865 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 82654007866 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 82654007867 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 82654007868 substrate binding site [chemical binding]; other site 82654007869 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 82654007870 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 82654007871 catalytic loop [active] 82654007872 iron binding site [ion binding]; other site 82654007873 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 82654007874 Catalytic site; other site 82654007875 Staphylococcal nuclease homologue; Region: SNase; pfam00565 82654007876 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 82654007877 ABC1 family; Region: ABC1; cl17513 82654007878 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 82654007879 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007880 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654007881 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007882 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007883 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654007884 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007885 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007886 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 82654007887 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 82654007888 FeS/SAM binding site; other site 82654007889 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 82654007890 Ligand Binding Site [chemical binding]; other site 82654007891 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 82654007892 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 82654007893 Cl- selectivity filter; other site 82654007894 Cl- binding residues [ion binding]; other site 82654007895 pore gating glutamate residue; other site 82654007896 dimer interface [polypeptide binding]; other site 82654007897 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 82654007898 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 82654007899 active site 82654007900 catalytic tetrad [active] 82654007901 PBP superfamily domain; Region: PBP_like_2; cl17296 82654007902 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 82654007903 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 82654007904 active site 82654007905 metal binding site [ion binding]; metal-binding site 82654007906 hexamer interface [polypeptide binding]; other site 82654007907 Methyltransferase domain; Region: Methyltransf_31; pfam13847 82654007908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654007909 S-adenosylmethionine binding site [chemical binding]; other site 82654007910 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 82654007911 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 82654007912 M42 glutamyl aminopeptidase; Region: Peptidase_M42; pfam05343 82654007913 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 82654007914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 82654007915 putative substrate translocation pore; other site 82654007916 prephenate dehydratase; Provisional; Region: PRK11898 82654007917 Prephenate dehydratase; Region: PDT; pfam00800 82654007918 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 82654007919 putative L-Phe binding site [chemical binding]; other site 82654007920 cell division protein; Validated; Region: ftsH; CHL00176 82654007921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654007922 Walker A motif; other site 82654007923 ATP binding site [chemical binding]; other site 82654007924 Walker B motif; other site 82654007925 arginine finger; other site 82654007926 Peptidase family M41; Region: Peptidase_M41; pfam01434 82654007927 30S ribosomal protein S1; Reviewed; Region: PRK07400 82654007928 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 82654007929 RNA binding site [nucleotide binding]; other site 82654007930 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 82654007931 RNA binding site [nucleotide binding]; other site 82654007932 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 82654007933 RNA binding site [nucleotide binding]; other site 82654007934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 82654007935 conserved hypothetical protein; Region: TIGR03492 82654007936 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654007937 putative active site [active] 82654007938 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654007939 putative active site [active] 82654007940 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654007941 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007942 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007943 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007944 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654007945 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007946 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007947 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007948 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007949 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654007950 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 82654007951 active site 82654007952 dimerization interface [polypeptide binding]; other site 82654007953 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 82654007954 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 82654007955 putative active site [active] 82654007956 Zn binding site [ion binding]; other site 82654007957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654007958 dimer interface [polypeptide binding]; other site 82654007959 conserved gate region; other site 82654007960 putative PBP binding loops; other site 82654007961 ABC-ATPase subunit interface; other site 82654007962 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 82654007963 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 82654007964 P loop; other site 82654007965 Nucleotide binding site [chemical binding]; other site 82654007966 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 82654007967 IHF dimer interface [polypeptide binding]; other site 82654007968 IHF - DNA interface [nucleotide binding]; other site 82654007969 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 82654007970 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 82654007971 oligomerization interface [polypeptide binding]; other site 82654007972 active site 82654007973 metal binding site [ion binding]; metal-binding site 82654007974 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 82654007975 SnoaL-like domain; Region: SnoaL_2; pfam12680 82654007976 DNA polymerase III subunit delta'; Validated; Region: PRK07399 82654007977 DNA polymerase III subunit delta'; Validated; Region: PRK08485 82654007978 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 82654007979 active site 82654007980 catalytic residues [active] 82654007981 metal binding site [ion binding]; metal-binding site 82654007982 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 82654007983 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 82654007984 Cache domain; Region: Cache_1; pfam02743 82654007985 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 82654007986 dimerization interface [polypeptide binding]; other site 82654007987 PAS domain S-box; Region: sensory_box; TIGR00229 82654007988 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654007989 putative active site [active] 82654007990 heme pocket [chemical binding]; other site 82654007991 Helix-turn-helix domain; Region: HTH_18; pfam12833 82654007992 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 82654007993 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 82654007994 DNA binding site [nucleotide binding] 82654007995 active site 82654007996 ribonuclease III; Reviewed; Region: rnc; PRK00102 82654007997 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 82654007998 dimerization interface [polypeptide binding]; other site 82654007999 active site 82654008000 metal binding site [ion binding]; metal-binding site 82654008001 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 82654008002 tellurium resistance terB-like protein; Region: terB_like; cd07177 82654008003 metal binding site [ion binding]; metal-binding site 82654008004 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 82654008005 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 82654008006 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 82654008007 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 82654008008 TM-ABC transporter signature motif; other site 82654008009 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 82654008010 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 82654008011 Walker A/P-loop; other site 82654008012 ATP binding site [chemical binding]; other site 82654008013 Q-loop/lid; other site 82654008014 ABC transporter signature motif; other site 82654008015 Walker B; other site 82654008016 D-loop; other site 82654008017 H-loop/switch region; other site 82654008018 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 82654008019 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 82654008020 Walker A/P-loop; other site 82654008021 ATP binding site [chemical binding]; other site 82654008022 Q-loop/lid; other site 82654008023 ABC transporter signature motif; other site 82654008024 Walker B; other site 82654008025 D-loop; other site 82654008026 H-loop/switch region; other site 82654008027 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 82654008028 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 82654008029 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 82654008030 dimer interface [polypeptide binding]; other site 82654008031 motif 1; other site 82654008032 active site 82654008033 motif 2; other site 82654008034 motif 3; other site 82654008035 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 82654008036 dimer interface [polypeptide binding]; other site 82654008037 allosteric magnesium binding site [ion binding]; other site 82654008038 active site 82654008039 aspartate-rich active site metal binding site; other site 82654008040 Schiff base residues; other site 82654008041 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 82654008042 multifunctional aminopeptidase A; Provisional; Region: PRK00913 82654008043 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 82654008044 interface (dimer of trimers) [polypeptide binding]; other site 82654008045 Substrate-binding/catalytic site; other site 82654008046 Zn-binding sites [ion binding]; other site 82654008047 Iron permease FTR1 family; Region: FTR1; cl00475 82654008048 PRC-barrel domain; Region: PRC; pfam05239 82654008049 PRC-barrel domain; Region: PRC; pfam05239 82654008050 citrate synthase; Provisional; Region: PRK14036 82654008051 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 82654008052 oxalacetate binding site [chemical binding]; other site 82654008053 citrylCoA binding site [chemical binding]; other site 82654008054 coenzyme A binding site [chemical binding]; other site 82654008055 catalytic triad [active] 82654008056 Bacitracin resistance protein BacA; Region: BacA; pfam02673 82654008057 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 82654008058 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 82654008059 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 82654008060 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 82654008061 catalytic residues [active] 82654008062 Methyltransferase domain; Region: Methyltransf_23; pfam13489 82654008063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654008064 S-adenosylmethionine binding site [chemical binding]; other site 82654008065 V-type ATP synthase subunit E; Provisional; Region: PRK01558 82654008066 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 82654008067 S-layer homology domain; Region: SLH; pfam00395 82654008068 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 82654008069 molecular chaperone DnaK; Provisional; Region: PRK13410 82654008070 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 82654008071 nucleotide binding site [chemical binding]; other site 82654008072 NEF interaction site [polypeptide binding]; other site 82654008073 SBD interface [polypeptide binding]; other site 82654008074 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 82654008075 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 82654008076 ligand binding site [chemical binding]; other site 82654008077 flexible hinge region; other site 82654008078 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654008079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654008080 ATP binding site [chemical binding]; other site 82654008081 Mg2+ binding site [ion binding]; other site 82654008082 G-X-G motif; other site 82654008083 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 82654008084 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 82654008085 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 82654008086 substrate binding site; other site 82654008087 tetramer interface; other site 82654008088 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 82654008089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654008090 dimer interface [polypeptide binding]; other site 82654008091 conserved gate region; other site 82654008092 putative PBP binding loops; other site 82654008093 ABC-ATPase subunit interface; other site 82654008094 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 82654008095 nucleoside/Zn binding site; other site 82654008096 dimer interface [polypeptide binding]; other site 82654008097 catalytic motif [active] 82654008098 spermidine synthase; Provisional; Region: PRK03612 82654008099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 82654008100 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 82654008101 Predicted acyl esterases [General function prediction only]; Region: COG2936 82654008102 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 82654008103 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654008104 putative active site [active] 82654008105 Aluminium resistance protein; Region: Alum_res; pfam06838 82654008106 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 82654008107 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 82654008108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654008109 active site 82654008110 phosphorylation site [posttranslational modification] 82654008111 intermolecular recognition site; other site 82654008112 dimerization interface [polypeptide binding]; other site 82654008113 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 82654008114 DNA binding residues [nucleotide binding] 82654008115 dimerization interface [polypeptide binding]; other site 82654008116 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 82654008117 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 82654008118 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 82654008119 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 82654008120 TPR repeat; Region: TPR_11; pfam13414 82654008121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654008122 binding surface 82654008123 TPR motif; other site 82654008124 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 82654008125 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654008126 binding surface 82654008127 TPR motif; other site 82654008128 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654008129 binding surface 82654008130 TPR motif; other site 82654008131 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 82654008132 putative active site [active] 82654008133 homotetrameric interface [polypeptide binding]; other site 82654008134 metal binding site [ion binding]; metal-binding site 82654008135 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654008136 putative active site [active] 82654008137 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 82654008138 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 82654008139 putative active site [active] 82654008140 metal binding site [ion binding]; metal-binding site 82654008141 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 82654008142 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 82654008143 nucleotide binding pocket [chemical binding]; other site 82654008144 K-X-D-G motif; other site 82654008145 catalytic site [active] 82654008146 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 82654008147 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 82654008148 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 82654008149 Dimer interface [polypeptide binding]; other site 82654008150 BRCT sequence motif; other site 82654008151 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 82654008152 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 82654008153 Active Sites [active] 82654008154 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 82654008155 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 82654008156 dimer interface [polypeptide binding]; other site 82654008157 tetramer interface [polypeptide binding]; other site 82654008158 PYR/PP interface [polypeptide binding]; other site 82654008159 TPP binding site [chemical binding]; other site 82654008160 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 82654008161 TPP-binding site [chemical binding]; other site 82654008162 Response regulator receiver domain; Region: Response_reg; pfam00072 82654008163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654008164 active site 82654008165 phosphorylation site [posttranslational modification] 82654008166 intermolecular recognition site; other site 82654008167 dimerization interface [polypeptide binding]; other site 82654008168 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 82654008169 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 82654008170 metal binding site [ion binding]; metal-binding site 82654008171 active site 82654008172 I-site; other site 82654008173 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 82654008174 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 82654008175 ScpA/B protein; Region: ScpA_ScpB; cl00598 82654008176 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 82654008177 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 82654008178 active site 82654008179 putative DNA-binding cleft [nucleotide binding]; other site 82654008180 dimer interface [polypeptide binding]; other site 82654008181 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 82654008182 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 82654008183 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 82654008184 TIGR03032 family protein; Region: TIGR03032 82654008185 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 82654008186 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 82654008187 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 82654008188 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 82654008189 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 82654008190 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 82654008191 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 82654008192 C factor cell-cell signaling protein; Provisional; Region: PRK09009 82654008193 NADP binding site [chemical binding]; other site 82654008194 homodimer interface [polypeptide binding]; other site 82654008195 active site 82654008196 Protein of unknown function (DUF554); Region: DUF554; pfam04474 82654008197 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 82654008198 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 82654008199 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 82654008200 ABC transporter; Region: ABC_tran_2; pfam12848 82654008201 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 82654008202 Predicted esterase [General function prediction only]; Region: COG0400 82654008203 putative hydrolase; Provisional; Region: PRK11460 82654008204 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 82654008205 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 82654008206 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 82654008207 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 82654008208 Walker A/P-loop; other site 82654008209 ATP binding site [chemical binding]; other site 82654008210 Q-loop/lid; other site 82654008211 ABC transporter signature motif; other site 82654008212 Walker B; other site 82654008213 D-loop; other site 82654008214 H-loop/switch region; other site 82654008215 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 82654008216 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 82654008217 Walker A/P-loop; other site 82654008218 ATP binding site [chemical binding]; other site 82654008219 Q-loop/lid; other site 82654008220 ABC transporter signature motif; other site 82654008221 Walker B; other site 82654008222 D-loop; other site 82654008223 H-loop/switch region; other site 82654008224 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 82654008225 GMP synthase; Reviewed; Region: guaA; PRK00074 82654008226 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 82654008227 AMP/PPi binding site [chemical binding]; other site 82654008228 candidate oxyanion hole; other site 82654008229 catalytic triad [active] 82654008230 potential glutamine specificity residues [chemical binding]; other site 82654008231 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 82654008232 ATP Binding subdomain [chemical binding]; other site 82654008233 Ligand Binding sites [chemical binding]; other site 82654008234 Dimerization subdomain; other site 82654008235 hypothetical protein; Provisional; Region: PRK11281 82654008236 GUN4-like; Region: GUN4; pfam05419 82654008237 OstA-like protein; Region: OstA; pfam03968 82654008238 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 82654008239 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 82654008240 Walker A/P-loop; other site 82654008241 ATP binding site [chemical binding]; other site 82654008242 Q-loop/lid; other site 82654008243 ABC transporter signature motif; other site 82654008244 Walker B; other site 82654008245 D-loop; other site 82654008246 H-loop/switch region; other site 82654008247 Predicted permeases [General function prediction only]; Region: COG0795 82654008248 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 82654008249 alanine racemase; Reviewed; Region: alr; PRK00053 82654008250 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 82654008251 active site 82654008252 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 82654008253 dimer interface [polypeptide binding]; other site 82654008254 substrate binding site [chemical binding]; other site 82654008255 catalytic residues [active] 82654008256 GAF domain; Region: GAF; cl17456 82654008257 GAF domain; Region: GAF_2; pfam13185 82654008258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654008259 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654008260 dimer interface [polypeptide binding]; other site 82654008261 phosphorylation site [posttranslational modification] 82654008262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654008263 ATP binding site [chemical binding]; other site 82654008264 Mg2+ binding site [ion binding]; other site 82654008265 G-X-G motif; other site 82654008266 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 82654008267 putative catalytic site [active] 82654008268 putative phosphate binding site [ion binding]; other site 82654008269 active site 82654008270 metal binding site A [ion binding]; metal-binding site 82654008271 DNA binding site [nucleotide binding] 82654008272 putative AP binding site [nucleotide binding]; other site 82654008273 putative metal binding site B [ion binding]; other site 82654008274 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 82654008275 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 82654008276 HlyD family secretion protein; Region: HlyD_3; pfam13437 82654008277 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 82654008278 Protein export membrane protein; Region: SecD_SecF; cl14618 82654008279 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 82654008280 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 82654008281 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 82654008282 short chain dehydrogenase; Provisional; Region: PRK06179 82654008283 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 82654008284 NADP binding site [chemical binding]; other site 82654008285 active site 82654008286 steroid binding site; other site 82654008287 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 82654008288 PhoU domain; Region: PhoU; pfam01895 82654008289 PhoU domain; Region: PhoU; pfam01895 82654008290 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 82654008291 active site 82654008292 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 82654008293 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 82654008294 CoA-binding site [chemical binding]; other site 82654008295 ATP-binding [chemical binding]; other site 82654008296 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 82654008297 aromatic arch; other site 82654008298 DCoH dimer interaction site [polypeptide binding]; other site 82654008299 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 82654008300 DCoH tetramer interaction site [polypeptide binding]; other site 82654008301 substrate binding site [chemical binding]; other site 82654008302 Stage II sporulation protein; Region: SpoIID; pfam08486 82654008303 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 82654008304 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 82654008305 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 82654008306 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 82654008307 Zn2+ binding site [ion binding]; other site 82654008308 Mg2+ binding site [ion binding]; other site 82654008309 hydrolase, alpha/beta fold family protein; Region: PLN02824 82654008310 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 82654008311 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 82654008312 Qi binding site; other site 82654008313 intrachain domain interface; other site 82654008314 interchain domain interface [polypeptide binding]; other site 82654008315 heme bH binding site [chemical binding]; other site 82654008316 heme bL binding site [chemical binding]; other site 82654008317 Qo binding site; other site 82654008318 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 82654008319 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 82654008320 interchain domain interface [polypeptide binding]; other site 82654008321 intrachain domain interface; other site 82654008322 Qi binding site; other site 82654008323 Qo binding site; other site 82654008324 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 82654008325 DJ-1 family protein; Region: not_thiJ; TIGR01383 82654008326 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 82654008327 conserved cys residue [active] 82654008328 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 82654008329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 82654008330 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 82654008331 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 82654008332 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 82654008333 heme binding pocket [chemical binding]; other site 82654008334 heme ligand [chemical binding]; other site 82654008335 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 82654008336 catalytic loop [active] 82654008337 iron binding site [ion binding]; other site 82654008338 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 82654008339 4-alpha-glucanotransferase; Provisional; Region: PRK14508 82654008340 Protein of unknown function (DUF721); Region: DUF721; pfam05258 82654008341 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 82654008342 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 82654008343 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 82654008344 catalytic residue [active] 82654008345 CAAX protease self-immunity; Region: Abi; pfam02517 82654008346 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 82654008347 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 82654008348 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654008349 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654008350 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654008351 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654008352 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654008353 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 82654008354 16S/18S rRNA binding site [nucleotide binding]; other site 82654008355 S13e-L30e interaction site [polypeptide binding]; other site 82654008356 25S rRNA binding site [nucleotide binding]; other site 82654008357 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 82654008358 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654008359 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654008360 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654008361 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 82654008362 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 82654008363 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 82654008364 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 82654008365 Walker A/P-loop; other site 82654008366 ATP binding site [chemical binding]; other site 82654008367 Q-loop/lid; other site 82654008368 ABC transporter signature motif; other site 82654008369 Walker B; other site 82654008370 D-loop; other site 82654008371 H-loop/switch region; other site 82654008372 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 82654008373 Domain of unknown function DUF39; Region: DUF39; pfam01837 82654008374 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 82654008375 hydrophobic ligand binding site; other site 82654008376 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 82654008377 active site 82654008378 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 82654008379 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 82654008380 active site 82654008381 catalytic tetrad [active] 82654008382 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 82654008383 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 82654008384 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 82654008385 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 82654008386 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 82654008387 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 82654008388 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 82654008389 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 82654008390 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 82654008391 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 82654008392 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 82654008393 RNA polymerase sigma factor; Provisional; Region: PRK12518 82654008394 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 82654008395 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 82654008396 DNA binding residues [nucleotide binding] 82654008397 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 82654008398 dimer interface [polypeptide binding]; other site 82654008399 V-type ATP synthase subunit A; Provisional; Region: PRK04192 82654008400 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 82654008401 Walker A motif/ATP binding site; other site 82654008402 Walker B motif; other site 82654008403 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 82654008404 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 82654008405 ribonuclease E; Reviewed; Region: rne; PRK10811 82654008406 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 82654008407 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 82654008408 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 82654008409 Mg++ binding site [ion binding]; other site 82654008410 putative catalytic motif [active] 82654008411 putative substrate binding site [chemical binding]; other site 82654008412 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 82654008413 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349 82654008414 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 82654008415 active site 82654008416 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 82654008417 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_13; cd06348 82654008418 putative ligand binding site [chemical binding]; other site 82654008419 phycobillisome linker protein; Region: apcE; CHL00091 82654008420 Phycobilisome protein; Region: Phycobilisome; cl08227 82654008421 Phycobilisome protein; Region: Phycobilisome; cl08227 82654008422 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 82654008423 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 82654008424 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 82654008425 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 82654008426 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 82654008427 NAD binding site [chemical binding]; other site 82654008428 dimer interface [polypeptide binding]; other site 82654008429 substrate binding site [chemical binding]; other site 82654008430 tetramer (dimer of dimers) interface [polypeptide binding]; other site 82654008431 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 82654008432 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 82654008433 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 82654008434 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 82654008435 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 82654008436 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 82654008437 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 82654008438 RHS Repeat; Region: RHS_repeat; pfam05593 82654008439 RHS Repeat; Region: RHS_repeat; pfam05593 82654008440 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 82654008441 RHS Repeat; Region: RHS_repeat; pfam05593 82654008442 RHS Repeat; Region: RHS_repeat; pfam05593 82654008443 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 82654008444 RHS Repeat; Region: RHS_repeat; pfam05593 82654008445 RHS Repeat; Region: RHS_repeat; pfam05593 82654008446 RHS Repeat; Region: RHS_repeat; pfam05593 82654008447 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 82654008448 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 82654008449 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 82654008450 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 82654008451 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654008452 putative active site [active] 82654008453 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654008454 putative active site [active] 82654008455 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 82654008456 HlyD family secretion protein; Region: HlyD_3; pfam13437 82654008457 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 82654008458 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 82654008459 ligand binding site [chemical binding]; other site 82654008460 flexible hinge region; other site 82654008461 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 82654008462 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 82654008463 putative active site [active] 82654008464 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 82654008465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654008466 Walker A/P-loop; other site 82654008467 ATP binding site [chemical binding]; other site 82654008468 Q-loop/lid; other site 82654008469 ABC transporter signature motif; other site 82654008470 Walker B; other site 82654008471 D-loop; other site 82654008472 H-loop/switch region; other site 82654008473 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 82654008474 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 82654008475 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 82654008476 homotrimer interaction site [polypeptide binding]; other site 82654008477 active site 82654008478 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 82654008479 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 82654008480 nucleophilic elbow; other site 82654008481 catalytic triad; other site 82654008482 CpeS-like protein; Region: CpeS; pfam09367 82654008483 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 82654008484 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 82654008485 Recombinase; Region: Recombinase; pfam07508 82654008486 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 82654008487 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 82654008488 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 82654008489 NAD binding site [chemical binding]; other site 82654008490 homotetramer interface [polypeptide binding]; other site 82654008491 homodimer interface [polypeptide binding]; other site 82654008492 substrate binding site [chemical binding]; other site 82654008493 active site 82654008494 YGGT family; Region: YGGT; pfam02325 82654008495 heat shock protein 90; Provisional; Region: PRK05218 82654008496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654008497 ATP binding site [chemical binding]; other site 82654008498 Mg2+ binding site [ion binding]; other site 82654008499 G-X-G motif; other site 82654008500 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 82654008501 putative cation:proton antiport protein; Provisional; Region: PRK10669 82654008502 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 82654008503 TrkA-N domain; Region: TrkA_N; pfam02254 82654008504 Uncharacterized conserved protein [Function unknown]; Region: COG3791 82654008505 ornithine carbamoyltransferase; Provisional; Region: PRK00779 82654008506 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 82654008507 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 82654008508 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 82654008509 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 82654008510 acylphosphatase; Provisional; Region: PRK14423 82654008511 Bifunctional nuclease; Region: DNase-RNase; pfam02577 82654008512 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 82654008513 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 82654008514 active site 82654008515 HIGH motif; other site 82654008516 KMSKS motif; other site 82654008517 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 82654008518 tRNA binding surface [nucleotide binding]; other site 82654008519 anticodon binding site; other site 82654008520 Uncharacterized conserved protein [Function unknown]; Region: COG1432 82654008521 LabA_like proteins; Region: LabA; cd10911 82654008522 putative metal binding site [ion binding]; other site 82654008523 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 82654008524 FOG: CBS domain [General function prediction only]; Region: COG0517 82654008525 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 82654008526 FOG: CBS domain [General function prediction only]; Region: COG0517 82654008527 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 82654008528 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654008529 GAF domain; Region: GAF; pfam01590 82654008530 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 82654008531 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 82654008532 metal binding site [ion binding]; metal-binding site 82654008533 active site 82654008534 I-site; other site 82654008535 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 82654008536 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 82654008537 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 82654008538 TM-ABC transporter signature motif; other site 82654008539 FOG: WD40 repeat [General function prediction only]; Region: COG2319 82654008540 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 82654008541 structural tetrad; other site 82654008542 Response regulator receiver domain; Region: Response_reg; pfam00072 82654008543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654008544 active site 82654008545 phosphorylation site [posttranslational modification] 82654008546 intermolecular recognition site; other site 82654008547 dimerization interface [polypeptide binding]; other site 82654008548 PAS domain S-box; Region: sensory_box; TIGR00229 82654008549 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654008550 putative active site [active] 82654008551 heme pocket [chemical binding]; other site 82654008552 PAS domain S-box; Region: sensory_box; TIGR00229 82654008553 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654008554 putative active site [active] 82654008555 heme pocket [chemical binding]; other site 82654008556 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 82654008557 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654008558 putative active site [active] 82654008559 heme pocket [chemical binding]; other site 82654008560 Heme NO binding associated; Region: HNOBA; pfam07701 82654008561 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 82654008562 cyclase homology domain; Region: CHD; cd07302 82654008563 nucleotidyl binding site; other site 82654008564 metal binding site [ion binding]; metal-binding site 82654008565 dimer interface [polypeptide binding]; other site 82654008566 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 82654008567 Chain length determinant protein; Region: Wzz; pfam02706 82654008568 Chain length determinant protein; Region: Wzz; cl15801 82654008569 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 82654008570 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 82654008571 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 82654008572 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 82654008573 phosphopeptide binding site; other site 82654008574 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 82654008575 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 82654008576 DNA binding residues [nucleotide binding] 82654008577 dimerization interface [polypeptide binding]; other site 82654008578 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 82654008579 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 82654008580 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 82654008581 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 82654008582 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 82654008583 ADDz for ATRX, Dnmt3 and Dnmt3l PHD-like zinc finger domain; Region: ADDz; cl17040 82654008584 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 82654008585 heme-binding site [chemical binding]; other site 82654008586 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654008587 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654008588 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654008589 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654008590 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 82654008591 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 82654008592 iron-sulfur cluster [ion binding]; other site 82654008593 [2Fe-2S] cluster binding site [ion binding]; other site 82654008594 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 82654008595 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 82654008596 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654008597 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654008598 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654008599 Spore germination protein [General function prediction only]; Region: COG5401 82654008600 Sporulation and spore germination; Region: Germane; pfam10646 82654008601 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 82654008602 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 82654008603 Methyltransferase domain; Region: Methyltransf_26; pfam13659 82654008604 FtsH Extracellular; Region: FtsH_ext; pfam06480 82654008605 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 82654008606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654008607 Walker A motif; other site 82654008608 ATP binding site [chemical binding]; other site 82654008609 Walker B motif; other site 82654008610 arginine finger; other site 82654008611 Peptidase family M41; Region: Peptidase_M41; pfam01434 82654008612 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 82654008613 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 82654008614 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 82654008615 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 82654008616 Ycf46; Provisional; Region: ycf46; CHL00195 82654008617 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654008618 Walker A motif; other site 82654008619 ATP binding site [chemical binding]; other site 82654008620 Walker B motif; other site 82654008621 arginine finger; other site 82654008622 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 82654008623 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 82654008624 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 82654008625 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 82654008626 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 82654008627 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 82654008628 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 82654008629 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 82654008630 Walker A/P-loop; other site 82654008631 ATP binding site [chemical binding]; other site 82654008632 Q-loop/lid; other site 82654008633 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 82654008634 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 82654008635 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 82654008636 ABC transporter signature motif; other site 82654008637 Walker B; other site 82654008638 D-loop; other site 82654008639 H-loop/switch region; other site 82654008640 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 82654008641 MPT binding site; other site 82654008642 trimer interface [polypeptide binding]; other site 82654008643 Psb28 protein; Region: Psb28; cl04326 82654008644 Methyltransferase domain; Region: Methyltransf_24; pfam13578 82654008645 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 82654008646 active site lid residues [active] 82654008647 substrate binding pocket [chemical binding]; other site 82654008648 catalytic residues [active] 82654008649 substrate-Mg2+ binding site; other site 82654008650 aspartate-rich region 1; other site 82654008651 aspartate-rich region 2; other site 82654008652 phytoene desaturase; Region: phytoene_desat; TIGR02731 82654008653 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 82654008654 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 82654008655 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 82654008656 phosphopeptide binding site; other site 82654008657 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 82654008658 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 82654008659 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 82654008660 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 82654008661 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 82654008662 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 82654008663 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 82654008664 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 82654008665 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 82654008666 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 82654008667 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654008668 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 82654008669 Cytochrome c; Region: Cytochrom_C; cl11414 82654008670 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 82654008671 Penicillinase repressor; Region: Pencillinase_R; pfam03965 82654008672 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 82654008673 Domain of unknown function DUF39; Region: DUF39; cl14897 82654008674 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 82654008675 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654008676 Walker A motif; other site 82654008677 ATP binding site [chemical binding]; other site 82654008678 Walker B motif; other site 82654008679 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 82654008680 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 82654008681 putative active site [active] 82654008682 substrate binding site [chemical binding]; other site 82654008683 putative cosubstrate binding site; other site 82654008684 catalytic site [active] 82654008685 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 82654008686 substrate binding site [chemical binding]; other site 82654008687 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 82654008688 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 82654008689 MutS domain I; Region: MutS_I; pfam01624 82654008690 MutS domain II; Region: MutS_II; pfam05188 82654008691 MutS domain III; Region: MutS_III; pfam05192 82654008692 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 82654008693 Walker A/P-loop; other site 82654008694 ATP binding site [chemical binding]; other site 82654008695 Q-loop/lid; other site 82654008696 ABC transporter signature motif; other site 82654008697 Walker B; other site 82654008698 D-loop; other site 82654008699 H-loop/switch region; other site 82654008700 WYL domain; Region: WYL; pfam13280 82654008701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 82654008702 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 82654008703 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 82654008704 active site 82654008705 dimer interface [polypeptide binding]; other site 82654008706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654008707 S-adenosylmethionine binding site [chemical binding]; other site 82654008708 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 82654008709 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654008710 putative ADP-binding pocket [chemical binding]; other site 82654008711 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_37; cd04696 82654008712 nudix motif; other site 82654008713 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 82654008714 classical (c) SDRs; Region: SDR_c; cd05233 82654008715 NAD(P) binding site [chemical binding]; other site 82654008716 active site 82654008717 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 82654008718 Sulfate transporter family; Region: Sulfate_transp; pfam00916 82654008719 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 82654008720 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 82654008721 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 82654008722 ligand binding site [chemical binding]; other site 82654008723 flexible hinge region; other site 82654008724 FOG: WD40 repeat [General function prediction only]; Region: COG2319 82654008725 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 82654008726 structural tetrad; other site 82654008727 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 82654008728 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 82654008729 P-loop, Walker A motif; other site 82654008730 Base recognition motif; other site 82654008731 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 82654008732 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 82654008733 active site 82654008734 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 82654008735 proposed catalytic triad [active] 82654008736 active site nucleophile [active] 82654008737 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 82654008738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654008739 Methyltransferase domain; Region: Methyltransf_31; pfam13847 82654008740 S-adenosylmethionine binding site [chemical binding]; other site 82654008741 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 82654008742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654008743 dimer interface [polypeptide binding]; other site 82654008744 conserved gate region; other site 82654008745 putative PBP binding loops; other site 82654008746 ABC-ATPase subunit interface; other site 82654008747 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 82654008748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654008749 dimer interface [polypeptide binding]; other site 82654008750 conserved gate region; other site 82654008751 putative PBP binding loops; other site 82654008752 ABC-ATPase subunit interface; other site 82654008753 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 82654008754 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 82654008755 Walker A/P-loop; other site 82654008756 ATP binding site [chemical binding]; other site 82654008757 Q-loop/lid; other site 82654008758 ABC transporter signature motif; other site 82654008759 Walker B; other site 82654008760 D-loop; other site 82654008761 H-loop/switch region; other site 82654008762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654008763 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 82654008764 Walker A motif; other site 82654008765 ATP binding site [chemical binding]; other site 82654008766 Walker B motif; other site 82654008767 arginine finger; other site 82654008768 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 82654008769 metal ion-dependent adhesion site (MIDAS); other site 82654008770 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 82654008771 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 82654008772 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 82654008773 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 82654008774 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 82654008775 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 82654008776 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 82654008777 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 82654008778 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 82654008779 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 82654008780 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 82654008781 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 82654008782 dihydrodipicolinate synthase; Region: dapA; TIGR00674 82654008783 dimer interface [polypeptide binding]; other site 82654008784 active site 82654008785 catalytic residue [active] 82654008786 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 82654008787 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 82654008788 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 82654008789 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654008790 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654008791 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654008792 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654008793 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 82654008794 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 82654008795 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 82654008796 trimer interface [polypeptide binding]; other site 82654008797 active site 82654008798 substrate binding site [chemical binding]; other site 82654008799 CoA binding site [chemical binding]; other site 82654008800 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 82654008801 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 82654008802 substrate binding pocket [chemical binding]; other site 82654008803 membrane-bound complex binding site; other site 82654008804 hinge residues; other site 82654008805 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 82654008806 C-terminal peptidase (prc); Region: prc; TIGR00225 82654008807 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 82654008808 protein binding site [polypeptide binding]; other site 82654008809 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 82654008810 Catalytic dyad [active] 82654008811 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 82654008812 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 82654008813 putative active site [active] 82654008814 Zn binding site [ion binding]; other site 82654008815 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 82654008816 RimK-like ATP-grasp domain; Region: RimK; pfam08443 82654008817 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 82654008818 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 82654008819 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 82654008820 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 82654008821 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 82654008822 metal binding site 2 [ion binding]; metal-binding site 82654008823 putative DNA binding helix; other site 82654008824 metal binding site 1 [ion binding]; metal-binding site 82654008825 dimer interface [polypeptide binding]; other site 82654008826 structural Zn2+ binding site [ion binding]; other site 82654008827 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654008828 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 82654008829 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 82654008830 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654008831 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 82654008832 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 82654008833 active site 82654008834 shikimate kinase; Reviewed; Region: aroK; PRK00131 82654008835 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 82654008836 ADP binding site [chemical binding]; other site 82654008837 magnesium binding site [ion binding]; other site 82654008838 putative shikimate binding site; other site 82654008839 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 82654008840 tartrate dehydrogenase; Region: TTC; TIGR02089 82654008841 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 82654008842 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 82654008843 DNA binding site [nucleotide binding] 82654008844 catalytic residue [active] 82654008845 H2TH interface [polypeptide binding]; other site 82654008846 putative catalytic residues [active] 82654008847 turnover-facilitating residue; other site 82654008848 intercalation triad [nucleotide binding]; other site 82654008849 8OG recognition residue [nucleotide binding]; other site 82654008850 putative reading head residues; other site 82654008851 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 82654008852 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 82654008853 photosystem I reaction center subunit IV; Provisional; Region: PRK02749 82654008854 2TM domain; Region: 2TM; pfam13239 82654008855 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 82654008856 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 82654008857 catalytic triad [active] 82654008858 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 82654008859 dihydropteroate synthase; Region: DHPS; TIGR01496 82654008860 substrate binding pocket [chemical binding]; other site 82654008861 dimer interface [polypeptide binding]; other site 82654008862 inhibitor binding site; inhibition site 82654008863 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 82654008864 Creatinine amidohydrolase; Region: Creatininase; pfam02633 82654008865 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 82654008866 Coenzyme A binding pocket [chemical binding]; other site 82654008867 Response regulator receiver domain; Region: Response_reg; pfam00072 82654008868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654008869 active site 82654008870 phosphorylation site [posttranslational modification] 82654008871 intermolecular recognition site; other site 82654008872 dimerization interface [polypeptide binding]; other site 82654008873 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 82654008874 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 82654008875 metal binding site [ion binding]; metal-binding site 82654008876 active site 82654008877 I-site; other site 82654008878 Cache domain; Region: Cache_1; pfam02743 82654008879 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 82654008880 dimerization interface [polypeptide binding]; other site 82654008881 PAS fold; Region: PAS_4; pfam08448 82654008882 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654008883 putative active site [active] 82654008884 heme pocket [chemical binding]; other site 82654008885 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 82654008886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654008887 dimer interface [polypeptide binding]; other site 82654008888 phosphorylation site [posttranslational modification] 82654008889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654008890 ATP binding site [chemical binding]; other site 82654008891 Mg2+ binding site [ion binding]; other site 82654008892 G-X-G motif; other site 82654008893 Response regulator receiver domain; Region: Response_reg; pfam00072 82654008894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654008895 active site 82654008896 phosphorylation site [posttranslational modification] 82654008897 intermolecular recognition site; other site 82654008898 Response regulator receiver domain; Region: Response_reg; pfam00072 82654008899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654008900 active site 82654008901 phosphorylation site [posttranslational modification] 82654008902 intermolecular recognition site; other site 82654008903 dimerization interface [polypeptide binding]; other site 82654008904 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 82654008905 putative binding surface; other site 82654008906 active site 82654008907 phosphoglucomutase; Region: PLN02307 82654008908 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 82654008909 substrate binding site [chemical binding]; other site 82654008910 dimer interface [polypeptide binding]; other site 82654008911 active site 82654008912 metal binding site [ion binding]; metal-binding site 82654008913 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654008914 putative active site [active] 82654008915 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 82654008916 Histidine kinase; Region: HisKA_2; pfam07568 82654008917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654008918 ATP binding site [chemical binding]; other site 82654008919 Mg2+ binding site [ion binding]; other site 82654008920 G-X-G motif; other site 82654008921 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 82654008922 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 82654008923 P loop; other site 82654008924 Nucleotide binding site [chemical binding]; other site 82654008925 DTAP/Switch II; other site 82654008926 Switch I; other site 82654008927 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 82654008928 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 82654008929 putative dimer interface [polypeptide binding]; other site 82654008930 TPR repeat; Region: TPR_11; pfam13414 82654008931 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654008932 binding surface 82654008933 TPR motif; other site 82654008934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654008935 binding surface 82654008936 TPR motif; other site 82654008937 TPR repeat; Region: TPR_11; pfam13414 82654008938 Predicted membrane protein [Function unknown]; Region: COG3431 82654008939 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 82654008940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654008941 S-adenosylmethionine binding site [chemical binding]; other site 82654008942 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 82654008943 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 82654008944 phosphopeptide binding site; other site 82654008945 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 82654008946 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 82654008947 phosphopeptide binding site; other site 82654008948 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 82654008949 phosphopeptide binding site; other site 82654008950 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 82654008951 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 82654008952 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 82654008953 shikimate binding site; other site 82654008954 NAD(P) binding site [chemical binding]; other site 82654008955 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654008956 putative active site [active] 82654008957 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 82654008958 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 82654008959 DNA binding site [nucleotide binding] 82654008960 active site 82654008961 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 82654008962 intersubunit interface [polypeptide binding]; other site 82654008963 active site 82654008964 catalytic residue [active] 82654008965 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 82654008966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654008967 active site 82654008968 phosphorylation site [posttranslational modification] 82654008969 intermolecular recognition site; other site 82654008970 dimerization interface [polypeptide binding]; other site 82654008971 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 82654008972 DNA binding residues [nucleotide binding] 82654008973 dimerization interface [polypeptide binding]; other site 82654008974 bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500 82654008975 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 82654008976 active site 82654008977 dimer interface [polypeptide binding]; other site 82654008978 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 82654008979 active site 82654008980 SnoaL-like domain; Region: SnoaL_3; pfam13474 82654008981 SnoaL-like domain; Region: SnoaL_2; pfam12680 82654008982 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 82654008983 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 82654008984 active site residue [active] 82654008985 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 82654008986 active site residue [active] 82654008987 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 82654008988 active site 82654008989 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 82654008990 AMP binding site [chemical binding]; other site 82654008991 metal binding site [ion binding]; metal-binding site 82654008992 active site 82654008993 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 82654008994 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654008995 active site 82654008996 ATP binding site [chemical binding]; other site 82654008997 substrate binding site [chemical binding]; other site 82654008998 activation loop (A-loop); other site 82654008999 Response regulator receiver domain; Region: Response_reg; pfam00072 82654009000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654009001 active site 82654009002 phosphorylation site [posttranslational modification] 82654009003 intermolecular recognition site; other site 82654009004 dimerization interface [polypeptide binding]; other site 82654009005 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 82654009006 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 82654009007 metal binding site [ion binding]; metal-binding site 82654009008 active site 82654009009 I-site; other site 82654009010 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 82654009011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654009012 Walker A motif; other site 82654009013 ATP binding site [chemical binding]; other site 82654009014 Walker B motif; other site 82654009015 arginine finger; other site 82654009016 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 82654009017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654009018 active site 82654009019 phosphorylation site [posttranslational modification] 82654009020 intermolecular recognition site; other site 82654009021 dimerization interface [polypeptide binding]; other site 82654009022 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 82654009023 DNA binding site [nucleotide binding] 82654009024 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654009025 dimer interface [polypeptide binding]; other site 82654009026 phosphorylation site [posttranslational modification] 82654009027 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654009028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654009029 ATP binding site [chemical binding]; other site 82654009030 Mg2+ binding site [ion binding]; other site 82654009031 G-X-G motif; other site 82654009032 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654009033 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 82654009034 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 82654009035 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 82654009036 active site 82654009037 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 82654009038 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 82654009039 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 82654009040 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 82654009041 catalytic site [active] 82654009042 subunit interface [polypeptide binding]; other site 82654009043 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 82654009044 Ligand Binding Site [chemical binding]; other site 82654009045 Phosphoglycerate kinase; Region: PGK; pfam00162 82654009046 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 82654009047 substrate binding site [chemical binding]; other site 82654009048 hinge regions; other site 82654009049 ADP binding site [chemical binding]; other site 82654009050 catalytic site [active] 82654009051 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 82654009052 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 82654009053 dimer interface [polypeptide binding]; other site 82654009054 ssDNA binding site [nucleotide binding]; other site 82654009055 tetramer (dimer of dimers) interface [polypeptide binding]; other site 82654009056 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 82654009057 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 82654009058 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 82654009059 catalytic site [active] 82654009060 putative active site [active] 82654009061 putative substrate binding site [chemical binding]; other site 82654009062 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 82654009063 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 82654009064 B12 binding site [chemical binding]; other site 82654009065 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 82654009066 FeS/SAM binding site; other site 82654009067 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 82654009068 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 82654009069 Thf1-like protein; Reviewed; Region: PRK13266 82654009070 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 82654009071 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 82654009072 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 82654009073 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 82654009074 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 82654009075 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 82654009076 active site 82654009077 SAM binding site [chemical binding]; other site 82654009078 homodimer interface [polypeptide binding]; other site 82654009079 Predicted permeases [General function prediction only]; Region: COG0679 82654009080 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 82654009081 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 82654009082 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 82654009083 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 82654009084 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 82654009085 Domain of unknown function (DUF814); Region: DUF814; pfam05670 82654009086 putative phosphate acyltransferase; Provisional; Region: PRK05331 82654009087 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 82654009088 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 82654009089 dimer interface [polypeptide binding]; other site 82654009090 active site 82654009091 CoA binding pocket [chemical binding]; other site 82654009092 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 82654009093 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 82654009094 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 82654009095 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 82654009096 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 82654009097 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 82654009098 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 82654009099 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 82654009100 active site 82654009101 Uncharacterized conserved protein [Function unknown]; Region: COG0397 82654009102 hypothetical protein; Validated; Region: PRK00029 82654009103 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 82654009104 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 82654009105 putative active site [active] 82654009106 putative metal binding site [ion binding]; other site 82654009107 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 82654009108 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 82654009109 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 82654009110 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 82654009111 Protein of unknown function DUF58; Region: DUF58; pfam01882 82654009112 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654009113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654009114 active site 82654009115 phosphorylation site [posttranslational modification] 82654009116 intermolecular recognition site; other site 82654009117 dimerization interface [polypeptide binding]; other site 82654009118 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 82654009119 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 82654009120 active site 82654009121 dimer interface [polypeptide binding]; other site 82654009122 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 82654009123 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 82654009124 active site 82654009125 FMN binding site [chemical binding]; other site 82654009126 substrate binding site [chemical binding]; other site 82654009127 3Fe-4S cluster binding site [ion binding]; other site 82654009128 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 82654009129 domain interface; other site 82654009130 Ycf46; Provisional; Region: ycf46; CHL00195 82654009131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654009132 Walker A motif; other site 82654009133 ATP binding site [chemical binding]; other site 82654009134 Walker B motif; other site 82654009135 arginine finger; other site 82654009136 TPR repeat; Region: TPR_11; pfam13414 82654009137 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654009138 binding surface 82654009139 TPR motif; other site 82654009140 TPR repeat; Region: TPR_11; pfam13414 82654009141 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654009142 binding surface 82654009143 TPR motif; other site 82654009144 TPR repeat; Region: TPR_11; pfam13414 82654009145 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 82654009146 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 82654009147 putative tRNA-binding site [nucleotide binding]; other site 82654009148 B3/4 domain; Region: B3_4; pfam03483 82654009149 tRNA synthetase B5 domain; Region: B5; smart00874 82654009150 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 82654009151 dimer interface [polypeptide binding]; other site 82654009152 motif 1; other site 82654009153 motif 3; other site 82654009154 motif 2; other site 82654009155 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 82654009156 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 82654009157 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 82654009158 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 82654009159 Ligand Binding Site [chemical binding]; other site 82654009160 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 82654009161 Ligand Binding Site [chemical binding]; other site 82654009162 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 82654009163 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 82654009164 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 82654009165 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 82654009166 ligand binding site [chemical binding]; other site 82654009167 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 82654009168 putative switch regulator; other site 82654009169 non-specific DNA interactions [nucleotide binding]; other site 82654009170 DNA binding site [nucleotide binding] 82654009171 sequence specific DNA binding site [nucleotide binding]; other site 82654009172 putative cAMP binding site [chemical binding]; other site 82654009173 Methyltransferase domain; Region: Methyltransf_31; pfam13847 82654009174 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654009175 S-adenosylmethionine binding site [chemical binding]; other site 82654009176 Domain of unknown function DUF21; Region: DUF21; pfam01595 82654009177 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 82654009178 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 82654009179 Transporter associated domain; Region: CorC_HlyC; smart01091 82654009180 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 82654009181 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 82654009182 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 82654009183 anti sigma factor interaction site; other site 82654009184 regulatory phosphorylation site [posttranslational modification]; other site 82654009185 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 82654009186 active site 82654009187 metal binding site [ion binding]; metal-binding site 82654009188 dimerization interface [polypeptide binding]; other site 82654009189 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 82654009190 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 82654009191 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 82654009192 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 82654009193 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 82654009194 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 82654009195 putative active site [active] 82654009196 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 82654009197 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 82654009198 putative dimer interface [polypeptide binding]; other site 82654009199 putative anticodon binding site; other site 82654009200 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 82654009201 homodimer interface [polypeptide binding]; other site 82654009202 motif 1; other site 82654009203 motif 2; other site 82654009204 active site 82654009205 motif 3; other site 82654009206 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 82654009207 active site 82654009208 SAM binding site [chemical binding]; other site 82654009209 homodimer interface [polypeptide binding]; other site 82654009210 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 82654009211 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 82654009212 catalytic loop [active] 82654009213 iron binding site [ion binding]; other site 82654009214 chaperone protein DnaJ; Provisional; Region: PRK14293 82654009215 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 82654009216 HSP70 interaction site [polypeptide binding]; other site 82654009217 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 82654009218 substrate binding site [polypeptide binding]; other site 82654009219 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 82654009220 Zn binding sites [ion binding]; other site 82654009221 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 82654009222 dimer interface [polypeptide binding]; other site 82654009223 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 82654009224 CPxP motif; other site 82654009225 GTPase RsgA; Reviewed; Region: PRK12289 82654009226 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 82654009227 RNA binding site [nucleotide binding]; other site 82654009228 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 82654009229 GTPase/Zn-binding domain interface [polypeptide binding]; other site 82654009230 GTP/Mg2+ binding site [chemical binding]; other site 82654009231 G4 box; other site 82654009232 G5 box; other site 82654009233 G1 box; other site 82654009234 Switch I region; other site 82654009235 G2 box; other site 82654009236 G3 box; other site 82654009237 Switch II region; other site 82654009238 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 82654009239 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 82654009240 putative di-iron ligands [ion binding]; other site 82654009241 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 82654009242 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 82654009243 active site 82654009244 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 82654009245 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 82654009246 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 82654009247 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 82654009248 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 82654009249 putative active site [active] 82654009250 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 82654009251 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 82654009252 NADP-binding site; other site 82654009253 homotetramer interface [polypeptide binding]; other site 82654009254 substrate binding site [chemical binding]; other site 82654009255 homodimer interface [polypeptide binding]; other site 82654009256 active site 82654009257 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 82654009258 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 82654009259 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 82654009260 Cysteine-rich domain; Region: CCG; pfam02754 82654009261 Cysteine-rich domain; Region: CCG; pfam02754 82654009262 primosome assembly protein PriA; Validated; Region: PRK05580 82654009263 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 82654009264 ATP binding site [chemical binding]; other site 82654009265 putative Mg++ binding site [ion binding]; other site 82654009266 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 82654009267 nucleotide binding region [chemical binding]; other site 82654009268 ATP-binding site [chemical binding]; other site 82654009269 NACHT domain; Region: NACHT; pfam05729 82654009270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 82654009271 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 82654009272 D-xylulose kinase; Region: XylB; TIGR01312 82654009273 nucleotide binding site [chemical binding]; other site 82654009274 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 82654009275 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 82654009276 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 82654009277 active site 82654009278 metal binding site [ion binding]; metal-binding site 82654009279 amidophosphoribosyltransferase; Provisional; Region: PRK07349 82654009280 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 82654009281 active site 82654009282 tetramer interface [polypeptide binding]; other site 82654009283 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 82654009284 active site 82654009285 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 82654009286 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 82654009287 putative active site [active] 82654009288 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 82654009289 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 82654009290 tRNA; other site 82654009291 putative tRNA binding site [nucleotide binding]; other site 82654009292 putative NADP binding site [chemical binding]; other site 82654009293 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 82654009294 Glucokinase; Region: Glucokinase; pfam02685 82654009295 glucokinase, proteobacterial type; Region: glk; TIGR00749 82654009296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 82654009297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654009298 S-adenosylmethionine binding site [chemical binding]; other site 82654009299 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 82654009300 TPR repeat; Region: TPR_11; pfam13414 82654009301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654009302 binding surface 82654009303 TPR motif; other site 82654009304 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 82654009305 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654009306 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654009307 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654009308 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654009309 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654009310 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654009311 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654009312 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654009313 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654009314 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654009315 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654009316 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654009317 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654009318 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654009319 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654009320 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654009321 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 82654009322 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 82654009323 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 82654009324 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 82654009325 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 82654009326 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 82654009327 putative active site [active] 82654009328 oxyanion strand; other site 82654009329 catalytic triad [active] 82654009330 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 82654009331 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 82654009332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380 82654009333 Response regulator receiver domain; Region: Response_reg; pfam00072 82654009334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654009335 active site 82654009336 phosphorylation site [posttranslational modification] 82654009337 intermolecular recognition site; other site 82654009338 dimerization interface [polypeptide binding]; other site 82654009339 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 82654009340 metal binding site [ion binding]; metal-binding site 82654009341 active site 82654009342 I-site; other site 82654009343 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 82654009344 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 82654009345 hypothetical protein; Reviewed; Region: PRK12497 82654009346 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654009347 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654009348 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654009349 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 82654009350 nucleoside/Zn binding site; other site 82654009351 dimer interface [polypeptide binding]; other site 82654009352 catalytic motif [active] 82654009353 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 82654009354 TIGR04168 family protein; Region: TIGR04168 82654009355 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 82654009356 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 82654009357 Walker A/P-loop; other site 82654009358 ATP binding site [chemical binding]; other site 82654009359 Q-loop/lid; other site 82654009360 ABC transporter signature motif; other site 82654009361 Walker B; other site 82654009362 D-loop; other site 82654009363 H-loop/switch region; other site 82654009364 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654009365 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654009366 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654009367 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654009368 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654009369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654009370 ATP binding site [chemical binding]; other site 82654009371 Mg2+ binding site [ion binding]; other site 82654009372 G-X-G motif; other site 82654009373 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 82654009374 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 82654009375 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 82654009376 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 82654009377 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 82654009378 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 82654009379 ABC-ATPase subunit interface; other site 82654009380 dimer interface [polypeptide binding]; other site 82654009381 putative PBP binding regions; other site 82654009382 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 82654009383 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 82654009384 glutaminase active site [active] 82654009385 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 82654009386 dimer interface [polypeptide binding]; other site 82654009387 active site 82654009388 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 82654009389 dimer interface [polypeptide binding]; other site 82654009390 active site 82654009391 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 82654009392 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 82654009393 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 82654009394 DNA binding residues [nucleotide binding] 82654009395 dimerization interface [polypeptide binding]; other site 82654009396 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 82654009397 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 82654009398 dimer interface [polypeptide binding]; other site 82654009399 motif 1; other site 82654009400 active site 82654009401 motif 2; other site 82654009402 motif 3; other site 82654009403 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 82654009404 anticodon binding site; other site 82654009405 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 82654009406 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 82654009407 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 82654009408 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364 82654009409 Uncharacterized conserved protein [Function unknown]; Region: COG1262 82654009410 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 82654009411 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 82654009412 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 82654009413 putative active site [active] 82654009414 catalytic triad [active] 82654009415 putative dimer interface [polypeptide binding]; other site 82654009416 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 82654009417 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 82654009418 substrate binding site [chemical binding]; other site 82654009419 ATP binding site [chemical binding]; other site 82654009420 dihydroorotase; Provisional; Region: PRK07575 82654009421 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 82654009422 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 82654009423 active site 82654009424 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 82654009425 active site 82654009426 putative homodimer interface [polypeptide binding]; other site 82654009427 SAM binding site [chemical binding]; other site 82654009428 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 82654009429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654009430 S-adenosylmethionine binding site [chemical binding]; other site 82654009431 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 82654009432 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 82654009433 Ycf46; Provisional; Region: ycf46; CHL00195 82654009434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654009435 Walker A motif; other site 82654009436 ATP binding site [chemical binding]; other site 82654009437 Walker B motif; other site 82654009438 arginine finger; other site 82654009439 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 82654009440 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 82654009441 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 82654009442 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 82654009443 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 82654009444 FeS/SAM binding site; other site 82654009445 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 82654009446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654009447 ATP binding site [chemical binding]; other site 82654009448 Mg2+ binding site [ion binding]; other site 82654009449 G-X-G motif; other site 82654009450 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 82654009451 ATP binding site [chemical binding]; other site 82654009452 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 82654009453 Protein kinase domain; Region: Pkinase; pfam00069 82654009454 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654009455 active site 82654009456 ATP binding site [chemical binding]; other site 82654009457 activation loop (A-loop); other site 82654009458 Divergent AAA domain; Region: AAA_4; pfam04326 82654009459 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 82654009460 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 82654009461 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 82654009462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654009463 active site 82654009464 phosphorylation site [posttranslational modification] 82654009465 intermolecular recognition site; other site 82654009466 dimerization interface [polypeptide binding]; other site 82654009467 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 82654009468 DNA binding site [nucleotide binding] 82654009469 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 82654009470 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 82654009471 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 82654009472 active site 82654009473 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 82654009474 MoaE homodimer interface [polypeptide binding]; other site 82654009475 MoaD interaction [polypeptide binding]; other site 82654009476 active site residues [active] 82654009477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 82654009478 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 82654009479 Coenzyme A binding pocket [chemical binding]; other site 82654009480 Animal haem peroxidase; Region: An_peroxidase; pfam03098 82654009481 heme binding site [chemical binding]; other site 82654009482 substrate binding site [chemical binding]; other site 82654009483 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 82654009484 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 82654009485 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 82654009486 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 82654009487 trimer interface [polypeptide binding]; other site 82654009488 active site 82654009489 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 82654009490 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 82654009491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654009492 active site 82654009493 phosphorylation site [posttranslational modification] 82654009494 intermolecular recognition site; other site 82654009495 dimerization interface [polypeptide binding]; other site 82654009496 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 82654009497 DNA binding site [nucleotide binding] 82654009498 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 82654009499 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 82654009500 putative acyl-acceptor binding pocket; other site 82654009501 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 82654009502 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 82654009503 putative active site; other site 82654009504 catalytic triad [active] 82654009505 putative dimer interface [polypeptide binding]; other site 82654009506 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 82654009507 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 82654009508 active site 82654009509 metal binding site [ion binding]; metal-binding site 82654009510 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 82654009511 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654009512 dimer interface [polypeptide binding]; other site 82654009513 phosphorylation site [posttranslational modification] 82654009514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654009515 ATP binding site [chemical binding]; other site 82654009516 Mg2+ binding site [ion binding]; other site 82654009517 G-X-G motif; other site 82654009518 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 82654009519 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 82654009520 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 82654009521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654009522 active site 82654009523 phosphorylation site [posttranslational modification] 82654009524 intermolecular recognition site; other site 82654009525 dimerization interface [polypeptide binding]; other site 82654009526 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 82654009527 DNA binding site [nucleotide binding] 82654009528 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 82654009529 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 82654009530 substrate binding site [chemical binding]; other site 82654009531 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 82654009532 substrate binding site [chemical binding]; other site 82654009533 ligand binding site [chemical binding]; other site 82654009534 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 82654009535 Nitrogen regulatory protein P-II; Region: P-II; smart00938 82654009536 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 82654009537 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 82654009538 Walker A/P-loop; other site 82654009539 ATP binding site [chemical binding]; other site 82654009540 Q-loop/lid; other site 82654009541 ABC transporter signature motif; other site 82654009542 Walker B; other site 82654009543 D-loop; other site 82654009544 H-loop/switch region; other site 82654009545 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 82654009546 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 82654009547 alpha-gamma subunit interface [polypeptide binding]; other site 82654009548 beta-gamma subunit interface [polypeptide binding]; other site 82654009549 S-layer homology domain; Region: SLH; pfam00395 82654009550 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 82654009551 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 82654009552 gamma-beta subunit interface [polypeptide binding]; other site 82654009553 alpha-beta subunit interface [polypeptide binding]; other site 82654009554 urease subunit alpha; Reviewed; Region: ureC; PRK13207 82654009555 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 82654009556 subunit interactions [polypeptide binding]; other site 82654009557 active site 82654009558 flap region; other site 82654009559 2TM domain; Region: 2TM; pfam13239 82654009560 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 82654009561 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 82654009562 MoaE interaction surface [polypeptide binding]; other site 82654009563 MoeB interaction surface [polypeptide binding]; other site 82654009564 thiocarboxylated glycine; other site 82654009565 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 82654009566 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 82654009567 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 82654009568 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 82654009569 G1 box; other site 82654009570 putative GEF interaction site [polypeptide binding]; other site 82654009571 GTP/Mg2+ binding site [chemical binding]; other site 82654009572 Switch I region; other site 82654009573 G2 box; other site 82654009574 G3 box; other site 82654009575 Switch II region; other site 82654009576 G4 box; other site 82654009577 G5 box; other site 82654009578 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 82654009579 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 82654009580 Predicted membrane protein [Function unknown]; Region: COG4803 82654009581 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 82654009582 non-specific DNA binding site [nucleotide binding]; other site 82654009583 salt bridge; other site 82654009584 sequence-specific DNA binding site [nucleotide binding]; other site 82654009585 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 82654009586 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 82654009587 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 82654009588 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 82654009589 adenylosuccinate lyase; Provisional; Region: PRK07380 82654009590 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 82654009591 tetramer interface [polypeptide binding]; other site 82654009592 active site 82654009593 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 82654009594 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 82654009595 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654009596 active site 82654009597 ATP binding site [chemical binding]; other site 82654009598 substrate binding site [chemical binding]; other site 82654009599 activation loop (A-loop); other site 82654009600 GUN4-like; Region: GUN4; pfam05419 82654009601 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 82654009602 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 82654009603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654009604 S-adenosylmethionine binding site [chemical binding]; other site 82654009605 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 82654009606 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 82654009607 putative C-terminal domain interface [polypeptide binding]; other site 82654009608 putative GSH binding site (G-site) [chemical binding]; other site 82654009609 putative dimer interface [polypeptide binding]; other site 82654009610 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 82654009611 N-terminal domain interface [polypeptide binding]; other site 82654009612 dimer interface [polypeptide binding]; other site 82654009613 substrate binding pocket (H-site) [chemical binding]; other site 82654009614 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 82654009615 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 82654009616 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 82654009617 putative active site pocket [active] 82654009618 4-fold oligomerization interface [polypeptide binding]; other site 82654009619 metal binding residues [ion binding]; metal-binding site 82654009620 3-fold/trimer interface [polypeptide binding]; other site 82654009621 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 82654009622 Domain of unknown function DUF20; Region: UPF0118; pfam01594 82654009623 Repair protein; Region: Repair_PSII; pfam04536 82654009624 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 82654009625 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 82654009626 GTP/Mg2+ binding site [chemical binding]; other site 82654009627 G4 box; other site 82654009628 G5 box; other site 82654009629 G1 box; other site 82654009630 Switch I region; other site 82654009631 G2 box; other site 82654009632 G3 box; other site 82654009633 Switch II region; other site 82654009634 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 82654009635 nudix motif; other site 82654009636 Class I aldolases; Region: Aldolase_Class_I; cl17187 82654009637 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 82654009638 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 82654009639 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 82654009640 active site 82654009641 catalytic tetrad [active] 82654009642 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 82654009643 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 82654009644 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 82654009645 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 82654009646 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 82654009647 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 82654009648 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 82654009649 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 82654009650 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654009651 active site 82654009652 ATP binding site [chemical binding]; other site 82654009653 substrate binding site [chemical binding]; other site 82654009654 activation loop (A-loop); other site 82654009655 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 82654009656 Clp protease ATP binding subunit; Region: clpC; CHL00095 82654009657 Clp amino terminal domain; Region: Clp_N; pfam02861 82654009658 Clp amino terminal domain; Region: Clp_N; pfam02861 82654009659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654009660 Walker A motif; other site 82654009661 ATP binding site [chemical binding]; other site 82654009662 Walker B motif; other site 82654009663 arginine finger; other site 82654009664 UvrB/uvrC motif; Region: UVR; pfam02151 82654009665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654009666 Walker A motif; other site 82654009667 ATP binding site [chemical binding]; other site 82654009668 Walker B motif; other site 82654009669 arginine finger; other site 82654009670 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 82654009671 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 82654009672 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 82654009673 Tetratricopeptide repeat; Region: TPR_12; pfam13424 82654009674 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654009675 binding surface 82654009676 TPR motif; other site 82654009677 Tetratricopeptide repeat; Region: TPR_16; pfam13432 82654009678 TPR repeat; Region: TPR_11; pfam13414 82654009679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654009680 binding surface 82654009681 TPR motif; other site 82654009682 TPR repeat; Region: TPR_11; pfam13414 82654009683 TPR repeat; Region: TPR_11; pfam13414 82654009684 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654009685 TPR motif; other site 82654009686 binding surface 82654009687 Tetratricopeptide repeat; Region: TPR_12; pfam13424 82654009688 Tetratricopeptide repeat; Region: TPR_16; pfam13432 82654009689 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654009690 binding surface 82654009691 TPR motif; other site 82654009692 TPR repeat; Region: TPR_11; pfam13414 82654009693 TPR repeat; Region: TPR_11; pfam13414 82654009694 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654009695 binding surface 82654009696 TPR motif; other site 82654009697 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 82654009698 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 82654009699 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 82654009700 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 82654009701 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 82654009702 dimer interface [polypeptide binding]; other site 82654009703 decamer (pentamer of dimers) interface [polypeptide binding]; other site 82654009704 catalytic triad [active] 82654009705 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 82654009706 carboxyl-terminal processing protease; Provisional; Region: PLN00049 82654009707 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 82654009708 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 82654009709 protein binding site [polypeptide binding]; other site 82654009710 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 82654009711 Catalytic dyad [active] 82654009712 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 82654009713 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 82654009714 substrate binding pocket [chemical binding]; other site 82654009715 membrane-bound complex binding site; other site 82654009716 hinge residues; other site 82654009717 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 82654009718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654009719 dimer interface [polypeptide binding]; other site 82654009720 conserved gate region; other site 82654009721 putative PBP binding loops; other site 82654009722 ABC-ATPase subunit interface; other site 82654009723 transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634 82654009724 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 82654009725 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 82654009726 catalytic loop [active] 82654009727 iron binding site [ion binding]; other site 82654009728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654009729 dimer interface [polypeptide binding]; other site 82654009730 conserved gate region; other site 82654009731 ABC-ATPase subunit interface; other site 82654009732 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 82654009733 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 82654009734 [2Fe-2S] cluster binding site [ion binding]; other site 82654009735 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 82654009736 hydrophobic ligand binding site; other site 82654009737 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654009738 TPR motif; other site 82654009739 binding surface 82654009740 TPR repeat; Region: TPR_11; pfam13414 82654009741 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654009742 binding surface 82654009743 TPR repeat; Region: TPR_11; pfam13414 82654009744 TPR motif; other site 82654009745 TPR repeat; Region: TPR_11; pfam13414 82654009746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654009747 TPR motif; other site 82654009748 binding surface 82654009749 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 82654009750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654009751 binding surface 82654009752 TPR motif; other site 82654009753 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 82654009754 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654009755 binding surface 82654009756 TPR motif; other site 82654009757 TPR repeat; Region: TPR_11; pfam13414 82654009758 TPR repeat; Region: TPR_11; pfam13414 82654009759 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654009760 binding surface 82654009761 TPR motif; other site 82654009762 TPR repeat; Region: TPR_11; pfam13414 82654009763 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654009764 binding surface 82654009765 TPR motif; other site 82654009766 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 82654009767 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 82654009768 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 82654009769 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 82654009770 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 82654009771 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 82654009772 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 82654009773 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 82654009774 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654009775 putative active site [active] 82654009776 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654009777 putative active site [active] 82654009778 Bacterial PH domain; Region: DUF304; pfam03703 82654009779 Psb28 protein; Region: Psb28; cl04326 82654009780 DNA primase; Validated; Region: dnaG; PRK05667 82654009781 CHC2 zinc finger; Region: zf-CHC2; cl17510 82654009782 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 82654009783 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 82654009784 active site 82654009785 metal binding site [ion binding]; metal-binding site 82654009786 interdomain interaction site; other site 82654009787 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 82654009788 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 82654009789 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654009790 putative ADP-binding pocket [chemical binding]; other site 82654009791 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 82654009792 Peptidase family M50; Region: Peptidase_M50; pfam02163 82654009793 active site 82654009794 putative substrate binding region [chemical binding]; other site 82654009795 light-harvesting-like protein 3; Provisional; Region: PLN00014 82654009796 prolyl-tRNA synthetase; Provisional; Region: PRK09194 82654009797 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 82654009798 dimer interface [polypeptide binding]; other site 82654009799 motif 1; other site 82654009800 active site 82654009801 motif 2; other site 82654009802 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 82654009803 putative deacylase active site [active] 82654009804 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 82654009805 active site 82654009806 motif 3; other site 82654009807 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 82654009808 anticodon binding site; other site 82654009809 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 82654009810 Protein of unknown function (DUF497); Region: DUF497; pfam04365 82654009811 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 82654009812 ribosomal protein S9; Region: rps9; CHL00079 82654009813 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 82654009814 23S rRNA interface [nucleotide binding]; other site 82654009815 L3 interface [polypeptide binding]; other site 82654009816 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 82654009817 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 82654009818 dimerization interface 3.5A [polypeptide binding]; other site 82654009819 active site 82654009820 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 82654009821 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 82654009822 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 82654009823 alphaNTD - beta interaction site [polypeptide binding]; other site 82654009824 alphaNTD homodimer interface [polypeptide binding]; other site 82654009825 alphaNTD - beta' interaction site [polypeptide binding]; other site 82654009826 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 82654009827 30S ribosomal protein S11; Validated; Region: PRK05309 82654009828 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 82654009829 30S ribosomal protein S13; Region: bact_S13; TIGR03631 82654009830 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 82654009831 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654009832 active site 82654009833 ATP binding site [chemical binding]; other site 82654009834 substrate binding site [chemical binding]; other site 82654009835 activation loop (A-loop); other site 82654009836 GUN4-like; Region: GUN4; pfam05419 82654009837 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 82654009838 Mechanosensitive ion channel; Region: MS_channel; pfam00924 82654009839 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 82654009840 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 82654009841 ligand binding site [chemical binding]; other site 82654009842 flexible hinge region; other site 82654009843 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 82654009844 homotrimer interface [polypeptide binding]; other site 82654009845 Walker A motif; other site 82654009846 GTP binding site [chemical binding]; other site 82654009847 Walker B motif; other site 82654009848 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654009849 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 82654009850 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 82654009851 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 82654009852 active site 82654009853 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 82654009854 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 82654009855 dimer interface [polypeptide binding]; other site 82654009856 putative metal binding site [ion binding]; other site 82654009857 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 82654009858 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 82654009859 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 82654009860 Tetramer interface [polypeptide binding]; other site 82654009861 active site 82654009862 FMN-binding site [chemical binding]; other site 82654009863 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 82654009864 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 82654009865 active site 82654009866 ATP binding site [chemical binding]; other site 82654009867 substrate binding site [chemical binding]; other site 82654009868 activation loop (A-loop); other site 82654009869 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 82654009870 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 82654009871 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 82654009872 cytochrome b subunit interaction site [polypeptide binding]; other site 82654009873 [2Fe-2S] cluster binding site [ion binding]; other site 82654009874 apocytochrome f; Reviewed; Region: PRK02693 82654009875 cytochrome f; Region: petA; CHL00037 82654009876 MarR family; Region: MarR; pfam01047 82654009877 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 82654009878 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 82654009879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654009880 dimer interface [polypeptide binding]; other site 82654009881 conserved gate region; other site 82654009882 putative PBP binding loops; other site 82654009883 ABC-ATPase subunit interface; other site 82654009884 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 82654009885 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654009886 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654009887 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654009888 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654009889 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654009890 dimer interface [polypeptide binding]; other site 82654009891 phosphorylation site [posttranslational modification] 82654009892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654009893 ATP binding site [chemical binding]; other site 82654009894 Mg2+ binding site [ion binding]; other site 82654009895 G-X-G motif; other site 82654009896 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654009897 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654009898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654009899 active site 82654009900 phosphorylation site [posttranslational modification] 82654009901 intermolecular recognition site; other site 82654009902 dimerization interface [polypeptide binding]; other site 82654009903 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 82654009904 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 82654009905 metal ion-dependent adhesion site (MIDAS); other site 82654009906 Double zinc ribbon; Region: DZR; pfam12773 82654009907 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 82654009908 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 82654009909 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 82654009910 phosphopeptide binding site; other site 82654009911 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 82654009912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654009913 S-adenosylmethionine binding site [chemical binding]; other site 82654009914 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 82654009915 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 82654009916 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 82654009917 Coenzyme A binding pocket [chemical binding]; other site 82654009918 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 82654009919 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 82654009920 spermidine synthase; Provisional; Region: PRK03612 82654009921 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 82654009922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654009923 S-adenosylmethionine binding site [chemical binding]; other site 82654009924 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 82654009925 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 82654009926 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 82654009927 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 82654009928 motif 1; other site 82654009929 active site 82654009930 motif 2; other site 82654009931 motif 3; other site 82654009932 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 82654009933 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 82654009934 thiS-thiF/thiG interaction site; other site 82654009935 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654009936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654009937 active site 82654009938 phosphorylation site [posttranslational modification] 82654009939 intermolecular recognition site; other site 82654009940 dimerization interface [polypeptide binding]; other site 82654009941 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654009942 GAF domain; Region: GAF_2; pfam13185 82654009943 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 82654009944 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 82654009945 hypothetical protein; Validated; Region: PRK00153 82654009946 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 82654009947 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 82654009948 Substrate binding site; other site 82654009949 Mg++ binding site; other site 82654009950 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 82654009951 active site 82654009952 substrate binding site [chemical binding]; other site 82654009953 CoA binding site [chemical binding]; other site 82654009954 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 82654009955 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 82654009956 G1 box; other site 82654009957 putative GEF interaction site [polypeptide binding]; other site 82654009958 GTP/Mg2+ binding site [chemical binding]; other site 82654009959 Switch I region; other site 82654009960 G2 box; other site 82654009961 G3 box; other site 82654009962 Switch II region; other site 82654009963 G4 box; other site 82654009964 G5 box; other site 82654009965 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 82654009966 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 82654009967 sequence-specific DNA binding site [nucleotide binding]; other site 82654009968 salt bridge; other site 82654009969 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 82654009970 classical (c) SDRs; Region: SDR_c; cd05233 82654009971 NAD(P) binding site [chemical binding]; other site 82654009972 active site 82654009973 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 82654009974 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 82654009975 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 82654009976 catalytic residue [active] 82654009977 FAD binding domain; Region: FAD_binding_4; pfam01565 82654009978 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 82654009979 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 82654009980 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 82654009981 putative C-terminal domain interface [polypeptide binding]; other site 82654009982 putative GSH binding site (G-site) [chemical binding]; other site 82654009983 putative dimer interface [polypeptide binding]; other site 82654009984 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 82654009985 putative N-terminal domain interface [polypeptide binding]; other site 82654009986 putative dimer interface [polypeptide binding]; other site 82654009987 putative substrate binding pocket (H-site) [chemical binding]; other site 82654009988 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 82654009989 active site 82654009990 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 82654009991 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 82654009992 FeS/SAM binding site; other site 82654009993 HemN C-terminal domain; Region: HemN_C; pfam06969 82654009994 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 82654009995 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 82654009996 Fe-S cluster binding site [ion binding]; other site 82654009997 active site 82654009998 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654009999 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654010000 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 82654010001 substrate binding site [chemical binding]; other site 82654010002 putative active site [active] 82654010003 redox center [active] 82654010004 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 82654010005 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 82654010006 active site 82654010007 catalytic residues [active] 82654010008 metal binding site [ion binding]; metal-binding site 82654010009 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 82654010010 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 82654010011 active site 82654010012 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 82654010013 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 82654010014 active site 82654010015 catalytic residues [active] 82654010016 metal binding site [ion binding]; metal-binding site 82654010017 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 82654010018 putative FMN binding site [chemical binding]; other site 82654010019 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 82654010020 putative lipid kinase; Reviewed; Region: PRK13057 82654010021 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 82654010022 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 82654010023 CHASE2 domain; Region: CHASE2; pfam05226 82654010024 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 82654010025 cyclase homology domain; Region: CHD; cd07302 82654010026 nucleotidyl binding site; other site 82654010027 metal binding site [ion binding]; metal-binding site 82654010028 dimer interface [polypeptide binding]; other site 82654010029 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 82654010030 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 82654010031 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 82654010032 NADPH bind site [chemical binding]; other site 82654010033 putative FMN binding site [chemical binding]; other site 82654010034 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 82654010035 putative FMN binding site [chemical binding]; other site 82654010036 NADPH bind site [chemical binding]; other site 82654010037 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 82654010038 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 82654010039 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 82654010040 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 82654010041 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 82654010042 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 82654010043 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 82654010044 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 82654010045 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 82654010046 putative active site [active] 82654010047 catalytic site [active] 82654010048 Domon-like ligand-binding domains; Region: DOMON_like; cd00241 82654010049 Late competence development protein ComFB; Region: ComFB; pfam10719 82654010050 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 82654010051 putative dimer interface [polypeptide binding]; other site 82654010052 active site pocket [active] 82654010053 putative cataytic base [active] 82654010054 Late competence development protein ComFB; Region: ComFB; pfam10719 82654010055 Late competence development protein ComFB; Region: ComFB; pfam10719 82654010056 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 82654010057 ATP-sulfurylase; Region: ATPS; cd00517 82654010058 active site 82654010059 HXXH motif; other site 82654010060 flexible loop; other site 82654010061 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 82654010062 Uncharacterized conserved protein [Function unknown]; Region: COG5607 82654010063 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654010064 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654010065 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 82654010066 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 82654010067 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 82654010068 active site 82654010069 catalytic residues [active] 82654010070 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 82654010071 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 82654010072 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 82654010073 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 82654010074 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 82654010075 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 82654010076 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 82654010077 active site 82654010078 metal binding site [ion binding]; metal-binding site 82654010079 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 82654010080 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 82654010081 Walker A/P-loop; other site 82654010082 ATP binding site [chemical binding]; other site 82654010083 Q-loop/lid; other site 82654010084 ABC transporter signature motif; other site 82654010085 Walker B; other site 82654010086 D-loop; other site 82654010087 H-loop/switch region; other site 82654010088 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 82654010089 FecR protein; Region: FecR; pfam04773 82654010090 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 82654010091 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 82654010092 Ligand Binding Site [chemical binding]; other site 82654010093 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 82654010094 diiron binding motif [ion binding]; other site 82654010095 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 82654010096 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 82654010097 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 82654010098 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 82654010099 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 82654010100 active site 82654010101 dimer interface [polypeptide binding]; other site 82654010102 metal binding site [ion binding]; metal-binding site 82654010103 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654010104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654010105 active site 82654010106 phosphorylation site [posttranslational modification] 82654010107 intermolecular recognition site; other site 82654010108 dimerization interface [polypeptide binding]; other site 82654010109 PAS domain S-box; Region: sensory_box; TIGR00229 82654010110 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654010111 putative active site [active] 82654010112 heme pocket [chemical binding]; other site 82654010113 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654010114 GAF domain; Region: GAF; cl17456 82654010115 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654010116 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654010117 dimer interface [polypeptide binding]; other site 82654010118 phosphorylation site [posttranslational modification] 82654010119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654010120 ATP binding site [chemical binding]; other site 82654010121 Mg2+ binding site [ion binding]; other site 82654010122 G-X-G motif; other site 82654010123 Response regulator receiver domain; Region: Response_reg; pfam00072 82654010124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654010125 active site 82654010126 phosphorylation site [posttranslational modification] 82654010127 intermolecular recognition site; other site 82654010128 dimerization interface [polypeptide binding]; other site 82654010129 Response regulator receiver domain; Region: Response_reg; pfam00072 82654010130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654010131 active site 82654010132 phosphorylation site [posttranslational modification] 82654010133 intermolecular recognition site; other site 82654010134 dimerization interface [polypeptide binding]; other site 82654010135 excinuclease ABC subunit B; Provisional; Region: PRK05298 82654010136 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 82654010137 ATP binding site [chemical binding]; other site 82654010138 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 82654010139 nucleotide binding region [chemical binding]; other site 82654010140 ATP-binding site [chemical binding]; other site 82654010141 Ultra-violet resistance protein B; Region: UvrB; pfam12344 82654010142 Predicted ATPase [General function prediction only]; Region: COG4637 82654010143 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654010144 Walker A/P-loop; other site 82654010145 ATP binding site [chemical binding]; other site 82654010146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 82654010147 Q-loop/lid; other site 82654010148 ABC transporter signature motif; other site 82654010149 Walker B; other site 82654010150 D-loop; other site 82654010151 H-loop/switch region; other site 82654010152 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 82654010153 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 82654010154 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 82654010155 putative NAD(P) binding site [chemical binding]; other site 82654010156 putative active site [active] 82654010157 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 82654010158 putative rRNA binding site [nucleotide binding]; other site 82654010159 gamma-glutamyl kinase; Provisional; Region: PRK05429 82654010160 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 82654010161 nucleotide binding site [chemical binding]; other site 82654010162 homotetrameric interface [polypeptide binding]; other site 82654010163 putative phosphate binding site [ion binding]; other site 82654010164 putative allosteric binding site; other site 82654010165 PUA domain; Region: PUA; pfam01472 82654010166 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 82654010167 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 82654010168 TPP-binding site; other site 82654010169 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 82654010170 PYR/PP interface [polypeptide binding]; other site 82654010171 dimer interface [polypeptide binding]; other site 82654010172 TPP binding site [chemical binding]; other site 82654010173 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 82654010174 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 82654010175 Predicted membrane protein [Function unknown]; Region: COG3463 82654010176 Predicted membrane protein [Function unknown]; Region: COG3463 82654010177 TIGR03943 family protein; Region: TIGR03943 82654010178 Predicted permeases [General function prediction only]; Region: COG0701 82654010179 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 82654010180 HEAT repeats; Region: HEAT_2; pfam13646 82654010181 protein binding surface [polypeptide binding]; other site 82654010182 HEAT repeats; Region: HEAT_2; pfam13646 82654010183 HEAT repeats; Region: HEAT_2; pfam13646 82654010184 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 82654010185 Family of unknown function (DUF490); Region: DUF490; pfam04357 82654010186 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 82654010187 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 82654010188 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 82654010189 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 82654010190 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 82654010191 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 82654010192 glutamine binding [chemical binding]; other site 82654010193 catalytic triad [active] 82654010194 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 82654010195 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 82654010196 active site 82654010197 DNA binding site [nucleotide binding] 82654010198 Int/Topo IB signature motif; other site 82654010199 Integrase core domain; Region: rve; pfam00665 82654010200 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 82654010201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654010202 Walker A motif; other site 82654010203 ATP binding site [chemical binding]; other site 82654010204 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 82654010205 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 82654010206 siderophore binding site; other site 82654010207 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 82654010208 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 82654010209 N-terminal plug; other site 82654010210 ligand-binding site [chemical binding]; other site 82654010211 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 82654010212 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 82654010213 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 82654010214 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 82654010215 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 82654010216 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 82654010217 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 82654010218 dimer interface [polypeptide binding]; other site 82654010219 putative PBP binding regions; other site 82654010220 ABC-ATPase subunit interface; other site 82654010221 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 82654010222 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 82654010223 ABC-ATPase subunit interface; other site 82654010224 dimer interface [polypeptide binding]; other site 82654010225 putative PBP binding regions; other site 82654010226 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 82654010227 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 82654010228 Walker A/P-loop; other site 82654010229 ATP binding site [chemical binding]; other site 82654010230 Q-loop/lid; other site 82654010231 ABC transporter signature motif; other site 82654010232 Walker B; other site 82654010233 D-loop; other site 82654010234 H-loop/switch region; other site 82654010235 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 82654010236 putative dimer interface [polypeptide binding]; other site 82654010237 putative [2Fe-2S] cluster binding site [ion binding]; other site 82654010238 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 82654010239 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 82654010240 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 82654010241 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 82654010242 intersubunit interface [polypeptide binding]; other site 82654010243 H+ Antiporter protein; Region: 2A0121; TIGR00900 82654010244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 82654010245 putative substrate translocation pore; other site 82654010246 H+ Antiporter protein; Region: 2A0121; TIGR00900 82654010247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 82654010248 putative substrate translocation pore; other site 82654010249 Predicted membrane protein [Function unknown]; Region: COG4280 82654010250 Domain of unknown function (DUF955); Region: DUF955; pfam06114 82654010251 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 82654010252 Cobalt transport protein; Region: CbiQ; cl00463 82654010253 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 82654010254 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 82654010255 arginine-tRNA ligase; Region: PLN02286 82654010256 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 82654010257 active site 82654010258 HIGH motif; other site 82654010259 KMSK motif region; other site 82654010260 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 82654010261 tRNA binding surface [nucleotide binding]; other site 82654010262 anticodon binding site; other site 82654010263 FOG: WD40 repeat [General function prediction only]; Region: COG2319 82654010264 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 82654010265 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 82654010266 Uncharacterized conserved protein [Function unknown]; Region: COG2006 82654010267 Domain of unknown function (DUF362); Region: DUF362; pfam04015 82654010268 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 82654010269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654010270 active site 82654010271 phosphorylation site [posttranslational modification] 82654010272 intermolecular recognition site; other site 82654010273 dimerization interface [polypeptide binding]; other site 82654010274 ferrochelatase; Reviewed; Region: hemH; PRK00035 82654010275 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 82654010276 C-terminal domain interface [polypeptide binding]; other site 82654010277 active site 82654010278 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 82654010279 active site 82654010280 N-terminal domain interface [polypeptide binding]; other site 82654010281 Uncharacterized conserved protein [Function unknown]; Region: COG2968 82654010282 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 82654010283 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 82654010284 putative binding site; other site 82654010285 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 82654010286 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 82654010287 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 82654010288 phosphopeptide binding site; other site 82654010289 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 82654010290 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 82654010291 intersubunit interface [polypeptide binding]; other site 82654010292 active site 82654010293 zinc binding site [ion binding]; other site 82654010294 Na+ binding site [ion binding]; other site 82654010295 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 82654010296 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 82654010297 active site 82654010298 Substrate binding site; other site 82654010299 Mg++ binding site; other site 82654010300 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 82654010301 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 82654010302 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 82654010303 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654010304 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654010305 PAS domain S-box; Region: sensory_box; TIGR00229 82654010306 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654010307 putative active site [active] 82654010308 heme pocket [chemical binding]; other site 82654010309 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 82654010310 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654010311 putative active site [active] 82654010312 heme pocket [chemical binding]; other site 82654010313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654010314 dimer interface [polypeptide binding]; other site 82654010315 phosphorylation site [posttranslational modification] 82654010316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654010317 ATP binding site [chemical binding]; other site 82654010318 Mg2+ binding site [ion binding]; other site 82654010319 G-X-G motif; other site 82654010320 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 82654010321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 82654010322 phosphoenolpyruvate synthase; Validated; Region: PRK06464 82654010323 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 82654010324 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 82654010325 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 82654010326 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 82654010327 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 82654010328 acyl-activating enzyme (AAE) consensus motif; other site 82654010329 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 82654010330 acyl-activating enzyme (AAE) consensus motif; other site 82654010331 putative AMP binding site [chemical binding]; other site 82654010332 putative active site [active] 82654010333 putative CoA binding site [chemical binding]; other site 82654010334 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 82654010335 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654010336 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654010337 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654010338 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 82654010339 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 82654010340 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 82654010341 generic binding surface II; other site 82654010342 ssDNA binding site; other site 82654010343 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 82654010344 ATP binding site [chemical binding]; other site 82654010345 putative Mg++ binding site [ion binding]; other site 82654010346 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 82654010347 nucleotide binding region [chemical binding]; other site 82654010348 ATP-binding site [chemical binding]; other site 82654010349 Methyltransferase domain; Region: Methyltransf_11; pfam08241 82654010350 cytochrome c biogenesis protein; Region: ccsA; CHL00045 82654010351 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 82654010352 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 82654010353 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 82654010354 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 82654010355 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 82654010356 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 82654010357 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654010358 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654010359 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654010360 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654010361 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 82654010362 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 82654010363 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 82654010364 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 82654010365 phosphopeptide binding site; other site 82654010366 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654010367 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654010368 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 82654010369 cyclase homology domain; Region: CHD; cd07302 82654010370 nucleotidyl binding site; other site 82654010371 metal binding site [ion binding]; metal-binding site 82654010372 dimer interface [polypeptide binding]; other site 82654010373 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 82654010374 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 82654010375 active site 82654010376 DNA binding site [nucleotide binding] 82654010377 Int/Topo IB signature motif; other site 82654010378 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 82654010379 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 82654010380 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 82654010381 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 82654010382 argininosuccinate synthase; Provisional; Region: PRK13820 82654010383 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 82654010384 ANP binding site [chemical binding]; other site 82654010385 Substrate Binding Site II [chemical binding]; other site 82654010386 Substrate Binding Site I [chemical binding]; other site 82654010387 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 82654010388 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 82654010389 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 82654010390 hexamer interface [polypeptide binding]; other site 82654010391 ligand binding site [chemical binding]; other site 82654010392 putative active site [active] 82654010393 NAD(P) binding site [chemical binding]; other site 82654010394 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 82654010395 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 82654010396 Lumazine binding domain; Region: Lum_binding; pfam00677 82654010397 Lumazine binding domain; Region: Lum_binding; pfam00677 82654010398 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 82654010399 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 82654010400 Walker A/P-loop; other site 82654010401 ATP binding site [chemical binding]; other site 82654010402 Q-loop/lid; other site 82654010403 ABC transporter signature motif; other site 82654010404 Walker B; other site 82654010405 D-loop; other site 82654010406 H-loop/switch region; other site 82654010407 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 82654010408 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 82654010409 metal ion-dependent adhesion site (MIDAS); other site 82654010410 SWIM zinc finger; Region: SWIM; pfam04434 82654010411 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 82654010412 active site 82654010413 catalytic triad [active] 82654010414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654010415 S-adenosylmethionine binding site [chemical binding]; other site 82654010416 GTP-binding protein Der; Reviewed; Region: PRK00093 82654010417 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 82654010418 G1 box; other site 82654010419 GTP/Mg2+ binding site [chemical binding]; other site 82654010420 Switch I region; other site 82654010421 G2 box; other site 82654010422 Switch II region; other site 82654010423 G3 box; other site 82654010424 G4 box; other site 82654010425 G5 box; other site 82654010426 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 82654010427 G1 box; other site 82654010428 GTP/Mg2+ binding site [chemical binding]; other site 82654010429 Switch I region; other site 82654010430 G2 box; other site 82654010431 G3 box; other site 82654010432 Switch II region; other site 82654010433 G4 box; other site 82654010434 G5 box; other site 82654010435 glutathione synthetase; Provisional; Region: PRK05246 82654010436 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 82654010437 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 82654010438 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 82654010439 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 82654010440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654010441 dimer interface [polypeptide binding]; other site 82654010442 phosphorylation site [posttranslational modification] 82654010443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654010444 ATP binding site [chemical binding]; other site 82654010445 Mg2+ binding site [ion binding]; other site 82654010446 G-X-G motif; other site 82654010447 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 82654010448 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 82654010449 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 82654010450 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 82654010451 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 82654010452 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 82654010453 GSH binding site [chemical binding]; other site 82654010454 catalytic residues [active] 82654010455 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 82654010456 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 82654010457 putative dimer interface [polypeptide binding]; other site 82654010458 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 82654010459 Pantoate-beta-alanine ligase; Region: PanC; cd00560 82654010460 active site 82654010461 ATP-binding site [chemical binding]; other site 82654010462 pantoate-binding site; other site 82654010463 HXXH motif; other site 82654010464 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 82654010465 active site 82654010466 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 82654010467 CMP-binding site; other site 82654010468 The sites determining sugar specificity; other site 82654010469 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 82654010470 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 82654010471 Moco binding site; other site 82654010472 metal coordination site [ion binding]; other site 82654010473 acetylornithine aminotransferase; Provisional; Region: PRK02627 82654010474 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 82654010475 inhibitor-cofactor binding pocket; inhibition site 82654010476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 82654010477 catalytic residue [active] 82654010478 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 82654010479 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 82654010480 Walker A/P-loop; other site 82654010481 ATP binding site [chemical binding]; other site 82654010482 Q-loop/lid; other site 82654010483 ABC transporter signature motif; other site 82654010484 Walker B; other site 82654010485 D-loop; other site 82654010486 H-loop/switch region; other site 82654010487 DevC protein; Region: devC; TIGR01185 82654010488 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 82654010489 FtsX-like permease family; Region: FtsX; pfam02687 82654010490 DevC protein; Region: devC; TIGR01185 82654010491 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 82654010492 FtsX-like permease family; Region: FtsX; pfam02687 82654010493 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 82654010494 HlyD family secretion protein; Region: HlyD_3; pfam13437 82654010495 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 82654010496 G1 box; other site 82654010497 GTP/Mg2+ binding site [chemical binding]; other site 82654010498 G2 box; other site 82654010499 Switch I region; other site 82654010500 G3 box; other site 82654010501 Switch II region; other site 82654010502 G4 box; other site 82654010503 G5 box; other site 82654010504 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 82654010505 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 82654010506 putative ligand binding site [chemical binding]; other site 82654010507 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 82654010508 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 82654010509 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 82654010510 TM-ABC transporter signature motif; other site 82654010511 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 82654010512 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 82654010513 TM-ABC transporter signature motif; other site 82654010514 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 82654010515 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 82654010516 Walker A/P-loop; other site 82654010517 ATP binding site [chemical binding]; other site 82654010518 Q-loop/lid; other site 82654010519 ABC transporter signature motif; other site 82654010520 Walker B; other site 82654010521 D-loop; other site 82654010522 H-loop/switch region; other site 82654010523 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 82654010524 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 82654010525 Walker A/P-loop; other site 82654010526 ATP binding site [chemical binding]; other site 82654010527 Q-loop/lid; other site 82654010528 ABC transporter signature motif; other site 82654010529 Walker B; other site 82654010530 D-loop; other site 82654010531 H-loop/switch region; other site 82654010532 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 82654010533 Glycoprotease family; Region: Peptidase_M22; pfam00814 82654010534 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 82654010535 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 82654010536 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 82654010537 Fanconi anaemia group C protein; Region: Fanconi_C; pfam02106 82654010538 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 82654010539 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 82654010540 active site 82654010541 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 82654010542 protein binding site [polypeptide binding]; other site 82654010543 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 82654010544 putative substrate binding region [chemical binding]; other site 82654010545 FOG: WD40 repeat [General function prediction only]; Region: COG2319 82654010546 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 82654010547 structural tetrad; other site 82654010548 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 82654010549 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 82654010550 P-loop, Walker A motif; other site 82654010551 Base recognition motif; other site 82654010552 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 82654010553 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 82654010554 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 82654010555 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 82654010556 ligand binding site [chemical binding]; other site 82654010557 flexible hinge region; other site 82654010558 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 82654010559 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 82654010560 putative active site [active] 82654010561 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 82654010562 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 82654010563 Walker A/P-loop; other site 82654010564 ATP binding site [chemical binding]; other site 82654010565 Q-loop/lid; other site 82654010566 ABC transporter signature motif; other site 82654010567 Walker B; other site 82654010568 D-loop; other site 82654010569 H-loop/switch region; other site 82654010570 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 82654010571 HlyD family secretion protein; Region: HlyD_3; pfam13437 82654010572 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 82654010573 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 82654010574 active site 82654010575 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 82654010576 carotene isomerase; Region: carot_isom; TIGR02730 82654010577 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 82654010578 hydroxyglutarate oxidase; Provisional; Region: PRK11728 82654010579 Domain of unknown function (DUF427); Region: DUF427; pfam04248 82654010580 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 82654010581 nucleotide binding site [chemical binding]; other site 82654010582 putative NEF/HSP70 interaction site [polypeptide binding]; other site 82654010583 SBD interface [polypeptide binding]; other site 82654010584 GrpE; Region: GrpE; pfam01025 82654010585 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 82654010586 dimer interface [polypeptide binding]; other site 82654010587 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 82654010588 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 82654010589 nucleotide binding site/active site [active] 82654010590 HIT family signature motif; other site 82654010591 catalytic residue [active] 82654010592 hypothetical protein; Provisional; Region: PRK02724 82654010593 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 82654010594 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 82654010595 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 82654010596 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 82654010597 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 82654010598 active site 82654010599 dimer interface [polypeptide binding]; other site 82654010600 motif 1; other site 82654010601 motif 2; other site 82654010602 motif 3; other site 82654010603 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 82654010604 anticodon binding site; other site 82654010605 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 82654010606 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 82654010607 putative metal binding residues [ion binding]; other site 82654010608 signature motif; other site 82654010609 dimer interface [polypeptide binding]; other site 82654010610 active site 82654010611 polyP binding site; other site 82654010612 substrate binding site [chemical binding]; other site 82654010613 acceptor-phosphate pocket; other site 82654010614 CotH protein; Region: CotH; pfam08757 82654010615 Right handed beta helix region; Region: Beta_helix; pfam13229 82654010616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654010617 S-adenosylmethionine binding site [chemical binding]; other site 82654010618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654010619 Methyltransferase domain; Region: Methyltransf_31; pfam13847 82654010620 S-adenosylmethionine binding site [chemical binding]; other site 82654010621 Right handed beta helix region; Region: Beta_helix; pfam13229 82654010622 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 82654010623 non-specific DNA binding site [nucleotide binding]; other site 82654010624 salt bridge; other site 82654010625 sequence-specific DNA binding site [nucleotide binding]; other site 82654010626 Phosphate acyltransferases; Region: PlsC; smart00563 82654010627 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 82654010628 signal recognition particle protein; Provisional; Region: PRK10867 82654010629 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 82654010630 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 82654010631 P loop; other site 82654010632 GTP binding site [chemical binding]; other site 82654010633 Signal peptide binding domain; Region: SRP_SPB; pfam02978 82654010634 ribosomal protein S16; Region: rps16; CHL00005 82654010635 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 82654010636 KH domain; Region: KH_4; pfam13083 82654010637 G-X-X-G motif; other site 82654010638 competence damage-inducible protein A; Provisional; Region: PRK00549 82654010639 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 82654010640 putative MPT binding site; other site 82654010641 Competence-damaged protein; Region: CinA; pfam02464 82654010642 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 82654010643 SmpB-tmRNA interface; other site 82654010644 Predicted membrane protein [Function unknown]; Region: COG2324 82654010645 helicase 45; Provisional; Region: PTZ00424 82654010646 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 82654010647 ATP binding site [chemical binding]; other site 82654010648 Mg++ binding site [ion binding]; other site 82654010649 motif III; other site 82654010650 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 82654010651 nucleotide binding region [chemical binding]; other site 82654010652 ATP-binding site [chemical binding]; other site 82654010653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 82654010654 Major Facilitator Superfamily; Region: MFS_1; pfam07690 82654010655 putative substrate translocation pore; other site 82654010656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 82654010657 putative substrate translocation pore; other site 82654010658 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 82654010659 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 82654010660 NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363 82654010661 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 82654010662 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 82654010663 polyphosphate kinase; Provisional; Region: PRK05443 82654010664 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 82654010665 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 82654010666 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 82654010667 putative domain interface [polypeptide binding]; other site 82654010668 putative active site [active] 82654010669 catalytic site [active] 82654010670 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 82654010671 putative domain interface [polypeptide binding]; other site 82654010672 putative active site [active] 82654010673 catalytic site [active] 82654010674 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 82654010675 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 82654010676 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 82654010677 ligand binding site [chemical binding]; other site 82654010678 flexible hinge region; other site 82654010679 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 82654010680 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 82654010681 Sulfate transporter family; Region: Sulfate_transp; pfam00916 82654010682 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 82654010683 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 82654010684 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 82654010685 ABC-ATPase subunit interface; other site 82654010686 dimer interface [polypeptide binding]; other site 82654010687 putative PBP binding regions; other site 82654010688 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 82654010689 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 82654010690 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 82654010691 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 82654010692 intersubunit interface [polypeptide binding]; other site 82654010693 CHASE3 domain; Region: CHASE3; pfam05227 82654010694 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 82654010695 dimerization interface [polypeptide binding]; other site 82654010696 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 82654010697 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 82654010698 dimer interface [polypeptide binding]; other site 82654010699 putative CheW interface [polypeptide binding]; other site 82654010700 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 82654010701 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 82654010702 dimer interface [polypeptide binding]; other site 82654010703 putative CheW interface [polypeptide binding]; other site 82654010704 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 82654010705 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 82654010706 putative binding surface; other site 82654010707 active site 82654010708 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 82654010709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654010710 ATP binding site [chemical binding]; other site 82654010711 Mg2+ binding site [ion binding]; other site 82654010712 G-X-G motif; other site 82654010713 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 82654010714 Response regulator receiver domain; Region: Response_reg; pfam00072 82654010715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654010716 active site 82654010717 phosphorylation site [posttranslational modification] 82654010718 intermolecular recognition site; other site 82654010719 dimerization interface [polypeptide binding]; other site 82654010720 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654010721 putative active site [active] 82654010722 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 82654010723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654010724 active site 82654010725 phosphorylation site [posttranslational modification] 82654010726 intermolecular recognition site; other site 82654010727 CheB methylesterase; Region: CheB_methylest; pfam01339 82654010728 Response regulator receiver domain; Region: Response_reg; pfam00072 82654010729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654010730 active site 82654010731 phosphorylation site [posttranslational modification] 82654010732 intermolecular recognition site; other site 82654010733 dimerization interface [polypeptide binding]; other site 82654010734 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654010735 dimer interface [polypeptide binding]; other site 82654010736 phosphorylation site [posttranslational modification] 82654010737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654010738 ATP binding site [chemical binding]; other site 82654010739 Mg2+ binding site [ion binding]; other site 82654010740 G-X-G motif; other site 82654010741 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 82654010742 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 82654010743 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 82654010744 TPR repeat; Region: TPR_11; pfam13414 82654010745 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654010746 binding surface 82654010747 TPR motif; other site 82654010748 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 82654010749 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 82654010750 RNase E interface [polypeptide binding]; other site 82654010751 trimer interface [polypeptide binding]; other site 82654010752 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 82654010753 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 82654010754 RNase E interface [polypeptide binding]; other site 82654010755 trimer interface [polypeptide binding]; other site 82654010756 active site 82654010757 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 82654010758 putative nucleic acid binding region [nucleotide binding]; other site 82654010759 G-X-X-G motif; other site 82654010760 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 82654010761 RNA binding site [nucleotide binding]; other site 82654010762 domain interface; other site 82654010763 FAD binding domain; Region: FAD_binding_4; pfam01565 82654010764 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 82654010765 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 82654010766 Periplasmic binding protein domain; Region: Peripla_BP_5; pfam13433 82654010767 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 82654010768 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 82654010769 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654010770 putative active site [active] 82654010771 heme pocket [chemical binding]; other site 82654010772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654010773 dimer interface [polypeptide binding]; other site 82654010774 phosphorylation site [posttranslational modification] 82654010775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654010776 ATP binding site [chemical binding]; other site 82654010777 Mg2+ binding site [ion binding]; other site 82654010778 G-X-G motif; other site 82654010779 hydrolase, alpha/beta fold family protein; Region: PLN02824 82654010780 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 82654010781 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 82654010782 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 82654010783 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 82654010784 FeS/SAM binding site; other site 82654010785 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 82654010786 Putative phosphatase (DUF442); Region: DUF442; cl17385 82654010787 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 82654010788 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 82654010789 HlyD family secretion protein; Region: HlyD_3; pfam13437 82654010790 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 82654010791 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654010792 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654010793 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654010794 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654010795 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654010796 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654010797 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654010798 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654010799 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654010800 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654010801 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654010802 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 82654010803 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654010804 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 82654010805 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 82654010806 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 82654010807 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 82654010808 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 82654010809 anti sigma factor interaction site; other site 82654010810 regulatory phosphorylation site [posttranslational modification]; other site 82654010811 Bacterial sugar transferase; Region: Bac_transf; pfam02397 82654010812 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 82654010813 Chain length determinant protein; Region: Wzz; cl15801 82654010814 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 82654010815 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 82654010816 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654010817 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 82654010818 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654010819 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 82654010820 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 82654010821 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 82654010822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654010823 active site 82654010824 phosphorylation site [posttranslational modification] 82654010825 intermolecular recognition site; other site 82654010826 dimerization interface [polypeptide binding]; other site 82654010827 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 82654010828 DNA binding site [nucleotide binding] 82654010829 Response regulator receiver domain; Region: Response_reg; pfam00072 82654010830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654010831 active site 82654010832 phosphorylation site [posttranslational modification] 82654010833 intermolecular recognition site; other site 82654010834 dimerization interface [polypeptide binding]; other site 82654010835 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 82654010836 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 82654010837 metal binding site [ion binding]; metal-binding site 82654010838 active site 82654010839 I-site; other site 82654010840 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654010841 TPR repeat; Region: TPR_11; pfam13414 82654010842 binding surface 82654010843 TPR motif; other site 82654010844 TPR repeat; Region: TPR_11; pfam13414 82654010845 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654010846 binding surface 82654010847 TPR motif; other site 82654010848 TPR repeat; Region: TPR_11; pfam13414 82654010849 TPR repeat; Region: TPR_11; pfam13414 82654010850 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654010851 binding surface 82654010852 TPR motif; other site 82654010853 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 82654010854 AAA domain; Region: AAA_33; pfam13671 82654010855 AAA domain; Region: AAA_17; pfam13207 82654010856 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 82654010857 catalytic residues [active] 82654010858 dimer interface [polypeptide binding]; other site 82654010859 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 82654010860 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 82654010861 ATP binding site [chemical binding]; other site 82654010862 putative Mg++ binding site [ion binding]; other site 82654010863 helicase superfamily c-terminal domain; Region: HELICc; smart00490 82654010864 nucleotide binding region [chemical binding]; other site 82654010865 ATP-binding site [chemical binding]; other site 82654010866 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 82654010867 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 82654010868 conserved cys residue [active] 82654010869 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 82654010870 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 82654010871 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 82654010872 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 82654010873 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 82654010874 substrate binding pocket [chemical binding]; other site 82654010875 chain length determination region; other site 82654010876 substrate-Mg2+ binding site; other site 82654010877 catalytic residues [active] 82654010878 aspartate-rich region 1; other site 82654010879 active site lid residues [active] 82654010880 aspartate-rich region 2; other site 82654010881 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 82654010882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 82654010883 active site 82654010884 phosphorylation site [posttranslational modification] 82654010885 intermolecular recognition site; other site 82654010886 dimerization interface [polypeptide binding]; other site 82654010887 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 82654010888 DNA binding site [nucleotide binding] 82654010889 glycogen synthase; Provisional; Region: glgA; PRK00654 82654010890 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 82654010891 ADP-binding pocket [chemical binding]; other site 82654010892 homodimer interface [polypeptide binding]; other site 82654010893 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 82654010894 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 82654010895 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 82654010896 metal-binding site [ion binding] 82654010897 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 82654010898 Soluble P-type ATPase [General function prediction only]; Region: COG4087 82654010899 Helix-turn-helix domain; Region: HTH_37; pfam13744 82654010900 lytic murein transglycosylase; Region: MltB_2; TIGR02283 82654010901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 82654010902 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 82654010903 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 82654010904 Part of AAA domain; Region: AAA_19; pfam13245 82654010905 Family description; Region: UvrD_C_2; pfam13538 82654010906 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 82654010907 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 82654010908 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 82654010909 ligand binding site; other site 82654010910 oligomer interface; other site 82654010911 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 82654010912 dimer interface [polypeptide binding]; other site 82654010913 N-terminal domain interface [polypeptide binding]; other site 82654010914 sulfate 1 binding site; other site 82654010915 ribosomal protein L33; Region: rpl33; CHL00104 82654010916 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 82654010917 Alternative oxidase, ferritin-like diiron-binding domain; Region: AOX; cd01053 82654010918 diiron binding motif [ion binding]; other site 82654010919 CHAT domain; Region: CHAT; cl17868 82654010920 Uncharacterized conserved protein [Function unknown]; Region: COG2928 82654010921 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 82654010922 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 82654010923 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 82654010924 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 82654010925 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 82654010926 Peptidase family M23; Region: Peptidase_M23; pfam01551 82654010927 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 82654010928 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 82654010929 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 82654010930 dimer interface [polypeptide binding]; other site 82654010931 motif 1; other site 82654010932 active site 82654010933 motif 2; other site 82654010934 motif 3; other site 82654010935 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 82654010936 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 82654010937 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 82654010938 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654010939 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654010940 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654010941 HEAT repeats; Region: HEAT_2; pfam13646 82654010942 GUN4-like; Region: GUN4; pfam05419 82654010943 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 82654010944 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 82654010945 active site 82654010946 catalytic residues [active] 82654010947 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 82654010948 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 82654010949 RNA binding surface [nucleotide binding]; other site 82654010950 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 82654010951 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 82654010952 iron-sulfur cluster [ion binding]; other site 82654010953 [2Fe-2S] cluster binding site [ion binding]; other site 82654010954 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 82654010955 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 82654010956 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 82654010957 iron-sulfur cluster [ion binding]; other site 82654010958 [2Fe-2S] cluster binding site [ion binding]; other site 82654010959 Uncharacterized conserved protein [Function unknown]; Region: COG3349 82654010960 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 82654010961 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 82654010962 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 82654010963 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 82654010964 Walker A/P-loop; other site 82654010965 ATP binding site [chemical binding]; other site 82654010966 Q-loop/lid; other site 82654010967 ABC transporter signature motif; other site 82654010968 Walker B; other site 82654010969 D-loop; other site 82654010970 H-loop/switch region; other site 82654010971 Conserved TM helix; Region: TM_helix; pfam05552 82654010972 Conserved TM helix; Region: TM_helix; pfam05552 82654010973 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 82654010974 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 82654010975 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 82654010976 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 82654010977 G-X-X-G motif; other site 82654010978 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 82654010979 RxxxH motif; other site 82654010980 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 82654010981 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 82654010982 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 82654010983 Bacterial PH domain; Region: DUF304; pfam03703 82654010984 Ribonuclease P; Region: Ribonuclease_P; cl00457 82654010985 Tic22-like family; Region: Tic22; cl04468 82654010986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654010987 Dynamin family; Region: Dynamin_N; pfam00350 82654010988 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 82654010989 G1 box; other site 82654010990 Walker A/P-loop; other site 82654010991 GTP/Mg2+ binding site [chemical binding]; other site 82654010992 ATP binding site [chemical binding]; other site 82654010993 Switch I region; other site 82654010994 G2 box; other site 82654010995 Switch II region; other site 82654010996 G3 box; other site 82654010997 G4 box; other site 82654010998 G5 box; other site 82654010999 Domain of unknown function (DUF697); Region: DUF697; pfam05128 82654011000 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 82654011001 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 82654011002 Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669 82654011003 oligomer interface [polypeptide binding]; other site 82654011004 SnoaL-like domain; Region: SnoaL_2; pfam12680 82654011005 SnoaL-like domain; Region: SnoaL_2; pfam12680 82654011006 SnoaL-like domain; Region: SnoaL_2; pfam12680 82654011007 SnoaL-like domain; Region: SnoaL_2; pfam12680 82654011008 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 82654011009 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 82654011010 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 82654011011 dimerization interface [polypeptide binding]; other site 82654011012 putative active cleft [active] 82654011013 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 82654011014 anti sigma factor interaction site; other site 82654011015 regulatory phosphorylation site [posttranslational modification]; other site 82654011016 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 82654011017 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme; Region: E_set_GDE_N; cd11234 82654011018 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 82654011019 active site 82654011020 catalytic site [active] 82654011021 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 82654011022 anti sigma factor interaction site; other site 82654011023 regulatory phosphorylation site [posttranslational modification]; other site 82654011024 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 82654011025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654011026 ATP binding site [chemical binding]; other site 82654011027 Mg2+ binding site [ion binding]; other site 82654011028 G-X-G motif; other site 82654011029 proline aminopeptidase P II; Provisional; Region: PRK10879 82654011030 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 82654011031 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 82654011032 active site 82654011033 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654011034 Staphylococcal nuclease homologues; Region: SNc; smart00318 82654011035 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 82654011036 Catalytic site; other site 82654011037 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 82654011038 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654011039 active site 82654011040 ATP binding site [chemical binding]; other site 82654011041 substrate binding site [chemical binding]; other site 82654011042 activation loop (A-loop); other site 82654011043 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 82654011044 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 82654011045 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 82654011046 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 82654011047 TM-ABC transporter signature motif; other site 82654011048 S-layer homology domain; Region: SLH; pfam00395 82654011049 S-layer homology domain; Region: SLH; pfam00395 82654011050 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 82654011051 MoaE interaction surface [polypeptide binding]; other site 82654011052 MoeB interaction surface [polypeptide binding]; other site 82654011053 thiocarboxylated glycine; other site 82654011054 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 82654011055 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 82654011056 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 82654011057 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 82654011058 putative active site [active] 82654011059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 82654011060 Ecdysteroid kinase; Region: EcKinase; cl17738 82654011061 Predicted kinase [General function prediction only]; Region: COG0645 82654011062 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 82654011063 active site 82654011064 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 82654011065 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 82654011066 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654011067 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 82654011068 Electron transfer DM13; Region: DM13; pfam10517 82654011069 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 82654011070 putative catalytic residues [active] 82654011071 Ion channel; Region: Ion_trans_2; pfam07885 82654011072 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 82654011073 TrkA-N domain; Region: TrkA_N; pfam02254 82654011074 TrkA-C domain; Region: TrkA_C; pfam02080 82654011075 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 82654011076 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654011077 dimer interface [polypeptide binding]; other site 82654011078 phosphorylation site [posttranslational modification] 82654011079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654011080 ATP binding site [chemical binding]; other site 82654011081 Mg2+ binding site [ion binding]; other site 82654011082 G-X-G motif; other site 82654011083 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 82654011084 active site residue [active] 82654011085 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 82654011086 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 82654011087 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654011088 dimer interface [polypeptide binding]; other site 82654011089 phosphorylation site [posttranslational modification] 82654011090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654011091 ATP binding site [chemical binding]; other site 82654011092 Mg2+ binding site [ion binding]; other site 82654011093 G-X-G motif; other site 82654011094 HEAT repeats; Region: HEAT_2; pfam13646 82654011095 HEAT repeats; Region: HEAT_2; pfam13646 82654011096 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 82654011097 Divergent PAP2 family; Region: DUF212; pfam02681 82654011098 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 82654011099 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 82654011100 substrate binding pocket [chemical binding]; other site 82654011101 chain length determination region; other site 82654011102 substrate-Mg2+ binding site; other site 82654011103 catalytic residues [active] 82654011104 aspartate-rich region 1; other site 82654011105 active site lid residues [active] 82654011106 aspartate-rich region 2; other site 82654011107 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 82654011108 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 82654011109 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 82654011110 homodimer interface [polypeptide binding]; other site 82654011111 NADP binding site [chemical binding]; other site 82654011112 substrate binding site [chemical binding]; other site 82654011113 6-phosphofructokinase; Provisional; Region: PRK14071 82654011114 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 82654011115 active site 82654011116 ADP/pyrophosphate binding site [chemical binding]; other site 82654011117 dimerization interface [polypeptide binding]; other site 82654011118 allosteric effector site; other site 82654011119 fructose-1,6-bisphosphate binding site; other site 82654011120 Domain of unknown function (DUF1817); Region: DUF1817; pfam08847 82654011121 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 82654011122 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 82654011123 dimer interface [polypeptide binding]; other site 82654011124 putative functional site; other site 82654011125 putative MPT binding site; other site 82654011126 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 82654011127 AAA domain; Region: AAA_26; pfam13500 82654011128 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 82654011129 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 82654011130 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 82654011131 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 82654011132 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 82654011133 putative active site [active] 82654011134 catalytic triad [active] 82654011135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 82654011136 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 82654011137 Protein of unknown function, DUF482; Region: DUF482; pfam04339 82654011138 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 82654011139 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 82654011140 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 82654011141 catalytic site [active] 82654011142 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 82654011143 putative active site pocket [active] 82654011144 dimerization interface [polypeptide binding]; other site 82654011145 putative catalytic residue [active] 82654011146 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 82654011147 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 82654011148 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 82654011149 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 82654011150 calcium/proton exchanger (cax); Region: cax; TIGR00378 82654011151 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 82654011152 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 82654011153 Mechanosensitive ion channel; Region: MS_channel; pfam00924 82654011154 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 82654011155 pseudouridine synthase; Region: TIGR00093 82654011156 active site 82654011157 PUCC protein; Region: PUCC; pfam03209 82654011158 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 82654011159 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 82654011160 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 82654011161 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 82654011162 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 82654011163 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 82654011164 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 82654011165 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 82654011166 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 82654011167 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 82654011168 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 82654011169 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 82654011170 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 82654011171 active site 82654011172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 82654011173 AAA domain; Region: AAA_21; pfam13304 82654011174 Walker A/P-loop; other site 82654011175 ATP binding site [chemical binding]; other site 82654011176 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 82654011177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 82654011178 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 82654011179 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654011180 active site 82654011181 ATP binding site [chemical binding]; other site 82654011182 substrate binding site [chemical binding]; other site 82654011183 activation loop (A-loop); other site 82654011184 PAS domain S-box; Region: sensory_box; TIGR00229 82654011185 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 82654011186 16S rRNA methyltransferase B; Provisional; Region: PRK14901 82654011187 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 82654011188 putative RNA binding site [nucleotide binding]; other site 82654011189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654011190 S-adenosylmethionine binding site [chemical binding]; other site 82654011191 aspartate aminotransferase; Provisional; Region: PRK05942 82654011192 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 82654011193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 82654011194 homodimer interface [polypeptide binding]; other site 82654011195 catalytic residue [active] 82654011196 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 82654011197 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 82654011198 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 82654011199 HlyD family secretion protein; Region: HlyD_3; pfam13437 82654011200 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 82654011201 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 82654011202 metal binding site 2 [ion binding]; metal-binding site 82654011203 putative DNA binding helix; other site 82654011204 metal binding site 1 [ion binding]; metal-binding site 82654011205 dimer interface [polypeptide binding]; other site 82654011206 structural Zn2+ binding site [ion binding]; other site 82654011207 chaperone protein DnaJ; Provisional; Region: PRK14299 82654011208 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 82654011209 HSP70 interaction site [polypeptide binding]; other site 82654011210 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 82654011211 dimer interface [polypeptide binding]; other site 82654011212 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 82654011213 anti sigma factor interaction site; other site 82654011214 regulatory phosphorylation site [posttranslational modification]; other site 82654011215 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 82654011216 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 82654011217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 82654011218 catalytic residue [active] 82654011219 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 82654011220 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 82654011221 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 82654011222 Zn2+ binding site [ion binding]; other site 82654011223 Mg2+ binding site [ion binding]; other site 82654011224 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 82654011225 synthetase active site [active] 82654011226 NTP binding site [chemical binding]; other site 82654011227 metal binding site [ion binding]; metal-binding site 82654011228 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 82654011229 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 82654011230 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 82654011231 DNA protecting protein DprA; Region: dprA; TIGR00732 82654011232 adenylate kinase; Reviewed; Region: adk; PRK00279 82654011233 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 82654011234 AMP-binding site [chemical binding]; other site 82654011235 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 82654011236 Late competence development protein ComFB; Region: ComFB; pfam10719 82654011237 Late competence development protein ComFB; Region: ComFB; pfam10719 82654011238 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 82654011239 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 82654011240 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 82654011241 ABC1 family; Region: ABC1; cl17513 82654011242 ABC-2 type transporter; Region: ABC2_membrane; cl17235 82654011243 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 82654011244 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 82654011245 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; cl03185 82654011246 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 82654011247 active site 82654011248 ribulose/triose binding site [chemical binding]; other site 82654011249 phosphate binding site [ion binding]; other site 82654011250 substrate (anthranilate) binding pocket [chemical binding]; other site 82654011251 product (indole) binding pocket [chemical binding]; other site 82654011252 Predicted integral membrane protein [Function unknown]; Region: COG0762 82654011253 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 82654011254 Clp amino terminal domain; Region: Clp_N; pfam02861 82654011255 Clp amino terminal domain; Region: Clp_N; pfam02861 82654011256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654011257 Walker A motif; other site 82654011258 ATP binding site [chemical binding]; other site 82654011259 Walker B motif; other site 82654011260 arginine finger; other site 82654011261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 82654011262 Walker A motif; other site 82654011263 ATP binding site [chemical binding]; other site 82654011264 Walker B motif; other site 82654011265 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 82654011266 Predicted membrane protein [Function unknown]; Region: COG1808 82654011267 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 82654011268 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654011269 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 82654011270 putative active site [active] 82654011271 heme pocket [chemical binding]; other site 82654011272 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654011273 putative active site [active] 82654011274 heme pocket [chemical binding]; other site 82654011275 PAS domain S-box; Region: sensory_box; TIGR00229 82654011276 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 82654011277 putative active site [active] 82654011278 heme pocket [chemical binding]; other site 82654011279 PAS domain; Region: PAS; smart00091 82654011280 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 82654011281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 82654011282 dimer interface [polypeptide binding]; other site 82654011283 phosphorylation site [posttranslational modification] 82654011284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 82654011285 ATP binding site [chemical binding]; other site 82654011286 Mg2+ binding site [ion binding]; other site 82654011287 G-X-G motif; other site 82654011288 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 82654011289 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 82654011290 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 82654011291 Malic enzyme, N-terminal domain; Region: malic; pfam00390 82654011292 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 82654011293 putative NAD(P) binding site [chemical binding]; other site 82654011294 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 82654011295 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 82654011296 four helix bundle protein; Region: TIGR02436 82654011297 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 82654011298 putative active site [active] 82654011299 transaldolase; Provisional; Region: PRK03903 82654011300 catalytic residue [active] 82654011301 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 82654011302 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 82654011303 hypothetical protein; Provisional; Region: PRK04323 82654011304 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 82654011305 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 82654011306 catalytic site [active] 82654011307 G-X2-G-X-G-K; other site 82654011308 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 82654011309 dimer interface [polypeptide binding]; other site 82654011310 [2Fe-2S] cluster binding site [ion binding]; other site 82654011311 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 82654011312 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 82654011313 active site 82654011314 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 82654011315 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 82654011316 phosphopeptide binding site; other site 82654011317 Protein kinase domain; Region: Pkinase; pfam00069 82654011318 Catalytic domain of Protein Kinases; Region: PKc; cd00180 82654011319 active site 82654011320 ATP binding site [chemical binding]; other site 82654011321 substrate binding site [chemical binding]; other site 82654011322 activation loop (A-loop); other site 82654011323 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 82654011324 Double zinc ribbon; Region: DZR; pfam12773 82654011325 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 82654011326 active site 82654011327 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 82654011328 Predicted chitinase [General function prediction only]; Region: COG3179 82654011329 catalytic residue [active] 82654011330 Bacterial SH3 domain; Region: SH3_3; cl17532 82654011331 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 82654011332 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 82654011333 NADP binding site [chemical binding]; other site 82654011334 substrate binding site [chemical binding]; other site 82654011335 active site 82654011336 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 82654011337 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 82654011338 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 82654011339 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 82654011340 DNA methylase; Region: N6_N4_Mtase; cl17433 82654011341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654011342 S-adenosylmethionine binding site [chemical binding]; other site 82654011343 cobalt transport protein CbiM; Validated; Region: PRK06265 82654011344 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 82654011345 cobalt transport protein CbiM; Validated; Region: PRK06265 82654011346 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 82654011347 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 82654011348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 82654011349 dimer interface [polypeptide binding]; other site 82654011350 conserved gate region; other site 82654011351 putative PBP binding loops; other site 82654011352 ABC-ATPase subunit interface; other site 82654011353 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 82654011354 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 82654011355 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 82654011356 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 82654011357 C-terminal domain of methyl-CpG binding protein 2 and 3; Region: MBD_C; pfam14048 82654011358 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 82654011359 Rhodanese-like domain; Region: Rhodanese; pfam00581 82654011360 active site residue [active] 82654011361 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 82654011362 active site residue [active] 82654011363 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 82654011364 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 82654011365 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 82654011366 OstA-like protein; Region: OstA; cl00844 82654011367 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 82654011368 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 82654011369 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 82654011370 active site 82654011371 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 82654011372 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 82654011373 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 82654011374 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 82654011375 active site 82654011376 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 82654011377 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 82654011378 active site 82654011379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 82654011380 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 82654011381 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 82654011382 Walker A/P-loop; other site 82654011383 ATP binding site [chemical binding]; other site 82654011384 Q-loop/lid; other site 82654011385 ABC transporter signature motif; other site 82654011386 Walker B; other site 82654011387 D-loop; other site 82654011388 H-loop/switch region; other site 82654011389 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 82654011390 putative carbohydrate binding site [chemical binding]; other site 82654011391 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 82654011392 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 82654011393 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 82654011394 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 82654011395 tandem repeat interface [polypeptide binding]; other site 82654011396 oligomer interface [polypeptide binding]; other site 82654011397 active site residues [active] 82654011398 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 82654011399 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 82654011400 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 82654011401 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 82654011402 NACHT domain; Region: NACHT; pfam05729 82654011403 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 82654011404 Uncharacterized conserved protein [Function unknown]; Region: COG3349 82654011405 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 82654011406 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 82654011407 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 82654011408 Phycobilisome protein; Region: Phycobilisome; cl08227 82654011409 Phycobilisome protein; Region: Phycobilisome; cl08227 82654011410 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 82654011411 Gas vesicle protein K; Region: GvpK; pfam05121 82654011412 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 82654011413 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 82654011414 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 82654011415 P-loop; other site 82654011416 Magnesium ion binding site [ion binding]; other site 82654011417 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 82654011418 Magnesium ion binding site [ion binding]; other site 82654011419 lipoyl synthase; Provisional; Region: PRK05481 82654011420 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 82654011421 FeS/SAM binding site; other site 82654011422 Methyltransferase domain; Region: Methyltransf_31; pfam13847 82654011423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654011424 S-adenosylmethionine binding site [chemical binding]; other site 82654011425 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 82654011426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 82654011427 NAD(P) binding site [chemical binding]; other site 82654011428 active site 82654011429 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 82654011430 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 82654011431 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 82654011432 NAD binding site [chemical binding]; other site 82654011433 homotetramer interface [polypeptide binding]; other site 82654011434 homodimer interface [polypeptide binding]; other site 82654011435 active site 82654011436 substrate binding site [chemical binding]; other site 82654011437 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 82654011438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 82654011439 NAD(P) binding site [chemical binding]; other site 82654011440 active site 82654011441 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654011442 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 82654011443 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 82654011444 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 82654011445 Catalytic site [active] 82654011446 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 82654011447 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 82654011448 Oligomerisation domain; Region: Oligomerisation; pfam02410 82654011449 H+ Antiporter protein; Region: 2A0121; TIGR00900 82654011450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 82654011451 putative substrate translocation pore; other site 82654011452 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 82654011453 Recombination protein O N terminal; Region: RecO_N; pfam11967 82654011454 Recombination protein O C terminal; Region: RecO_C; pfam02565 82654011455 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 82654011456 dinuclear metal binding motif [ion binding]; other site 82654011457 acyl-ACP reductase; Provisional; Region: PRK14982 82654011458 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 82654011459 NAD(P) binding pocket [chemical binding]; other site 82654011460 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 82654011461 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 82654011462 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 82654011463 Transposase [DNA replication, recombination, and repair]; Region: COG5421 82654011464 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 82654011465 sulfotransferase; Region: PLN02164 82654011466 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 82654011467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 82654011468 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 82654011469 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 82654011470 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 82654011471 Methyltransferase domain; Region: Methyltransf_23; pfam13489 82654011472 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 82654011473 S-adenosylmethionine binding site [chemical binding]; other site 82654011474 Lysyl-tRNA synthetase (class I) [Translation, ribosomal structure and biogenesis]; Region: LysS; COG1384 82654011475 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 82654011476 active site 82654011477 nucleotide binding site [chemical binding]; other site 82654011478 HIGH motif; other site 82654011479 KMSKS motif; other site 82654011480 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 82654011481 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 82654011482 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 82654011483 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 82654011484 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 82654011485 HSP70 interaction site [polypeptide binding]; other site 82654011486 TPR repeat; Region: TPR_11; pfam13414 82654011487 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 82654011488 binding surface 82654011489 TPR motif; other site 82654011490 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 82654011491 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 82654011492 substrate binding pocket [chemical binding]; other site 82654011493 membrane-bound complex binding site; other site 82654011494 hinge residues; other site 82654011495 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 82654011496 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 82654011497 Walker A/P-loop; other site 82654011498 ATP binding site [chemical binding]; other site 82654011499 Q-loop/lid; other site 82654011500 ABC transporter signature motif; other site 82654011501 Walker B; other site 82654011502 D-loop; other site 82654011503 H-loop/switch region; other site 82654011504 Methyltransferase domain; Region: Methyltransf_24; pfam13578 82654011505 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 82654011506 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 82654011507 PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990 82654011508 protein binding site [polypeptide binding]; other site 82654011509 Putative restriction endonuclease; Region: Uma2; pfam05685 82654011510 putative active site [active] 82654011511 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 82654011512 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 82654011513 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 82654011514 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 82654011515 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 82654011516 ATP-grasp domain; Region: ATP-grasp_4; cl17255 82654011517 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 82654011518 IMP binding site; other site 82654011519 dimer interface [polypeptide binding]; other site 82654011520 interdomain contacts; other site 82654011521 partial ornithine binding site; other site 82654011522 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 82654011523 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743