-- dump date 20140620_003608 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1093787000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787000002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1093787000003 Walker A motif; other site 1093787000004 ATP binding site [chemical binding]; other site 1093787000005 Walker B motif; other site 1093787000006 arginine finger; other site 1093787000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1093787000008 DnaA box-binding interface [nucleotide binding]; other site 1093787000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 1093787000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1093787000011 putative DNA binding surface [nucleotide binding]; other site 1093787000012 dimer interface [polypeptide binding]; other site 1093787000013 beta-clamp/clamp loader binding surface; other site 1093787000014 beta-clamp/translesion DNA polymerase binding surface; other site 1093787000015 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 1093787000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787000017 Walker A/P-loop; other site 1093787000018 ATP binding site [chemical binding]; other site 1093787000019 Q-loop/lid; other site 1093787000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787000021 ABC transporter signature motif; other site 1093787000022 Walker B; other site 1093787000023 D-loop; other site 1093787000024 H-loop/switch region; other site 1093787000025 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1093787000026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787000027 Mg2+ binding site [ion binding]; other site 1093787000028 G-X-G motif; other site 1093787000029 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1093787000030 anchoring element; other site 1093787000031 dimer interface [polypeptide binding]; other site 1093787000032 ATP binding site [chemical binding]; other site 1093787000033 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1093787000034 active site 1093787000035 putative metal-binding site [ion binding]; other site 1093787000036 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1093787000037 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1093787000038 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1093787000039 putative acyl-acceptor binding pocket; other site 1093787000040 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1093787000041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1093787000042 active site 1093787000043 motif I; other site 1093787000044 motif II; other site 1093787000045 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1093787000046 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1093787000047 dimer interface [polypeptide binding]; other site 1093787000048 motif 1; other site 1093787000049 active site 1093787000050 motif 2; other site 1093787000051 motif 3; other site 1093787000052 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1093787000053 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1093787000054 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1093787000055 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1093787000056 putative acyl-acceptor binding pocket; other site 1093787000057 PilZ domain; Region: PilZ; pfam07238 1093787000058 hypothetical protein; Provisional; Region: PRK11212 1093787000059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1093787000060 TPR motif; other site 1093787000061 TPR repeat; Region: TPR_11; pfam13414 1093787000062 binding surface 1093787000063 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1093787000064 TrkA-N domain; Region: TrkA_N; pfam02254 1093787000065 TrkA-C domain; Region: TrkA_C; pfam02080 1093787000066 TrkA-N domain; Region: TrkA_N; pfam02254 1093787000067 TrkA-C domain; Region: TrkA_C; pfam02080 1093787000068 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1093787000069 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1093787000070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787000071 S-adenosylmethionine binding site [chemical binding]; other site 1093787000072 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1093787000073 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1093787000074 putative active site [active] 1093787000075 substrate binding site [chemical binding]; other site 1093787000076 putative cosubstrate binding site; other site 1093787000077 catalytic site [active] 1093787000078 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1093787000079 substrate binding site [chemical binding]; other site 1093787000080 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1093787000081 active site 1093787000082 catalytic residues [active] 1093787000083 metal binding site [ion binding]; metal-binding site 1093787000084 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1093787000085 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1093787000086 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1093787000087 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1093787000088 DNA protecting protein DprA; Region: dprA; TIGR00732 1093787000089 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1093787000090 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1093787000091 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1093787000092 NADP binding site [chemical binding]; other site 1093787000093 dimer interface [polypeptide binding]; other site 1093787000094 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1093787000095 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1093787000096 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1093787000097 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1093787000098 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1093787000099 shikimate binding site; other site 1093787000100 NAD(P) binding site [chemical binding]; other site 1093787000101 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 1093787000102 Zn binding site [ion binding]; other site 1093787000103 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1093787000104 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1093787000105 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1093787000106 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1093787000107 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1093787000108 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1093787000109 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1093787000110 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1093787000111 choline-sulfatase; Region: chol_sulfatase; TIGR03417 1093787000112 Sulfatase; Region: Sulfatase; cl17466 1093787000113 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 1093787000114 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1093787000115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787000116 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1093787000117 dimerization interface [polypeptide binding]; other site 1093787000118 substrate binding pocket [chemical binding]; other site 1093787000119 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 1093787000120 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1093787000121 putative binding surface; other site 1093787000122 active site 1093787000123 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1093787000124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787000125 active site 1093787000126 phosphorylation site [posttranslational modification] 1093787000127 intermolecular recognition site; other site 1093787000128 dimerization interface [polypeptide binding]; other site 1093787000129 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787000130 DNA binding residues [nucleotide binding] 1093787000131 dimerization interface [polypeptide binding]; other site 1093787000132 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1093787000133 substrate binding site [chemical binding]; other site 1093787000134 active site 1093787000135 catalytic residues [active] 1093787000136 heterodimer interface [polypeptide binding]; other site 1093787000137 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1093787000138 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1093787000139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787000140 catalytic residue [active] 1093787000141 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1093787000142 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787000143 The C-terminal substrate binding domain of LysR-type transcriptional regulator TrpI, which is involved in control of tryptophan synthesis, contains type 2 periplasmic binding fold; Region: PBP2_TrpI; cd08482 1093787000144 putative dimerization interface [polypeptide binding]; other site 1093787000145 putative substrate binding pocket [chemical binding]; other site 1093787000146 Dodecin; Region: Dodecin; pfam07311 1093787000147 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1093787000148 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1093787000149 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1093787000150 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1093787000151 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1093787000152 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1093787000153 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1093787000154 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 1093787000155 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1093787000156 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1093787000157 Predicted membrane protein [Function unknown]; Region: COG3174 1093787000158 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 1093787000159 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 1093787000160 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219 1093787000161 switch II binding region; other site 1093787000162 Rac1 P-loop interaction site [polypeptide binding]; other site 1093787000163 GTP binding residues [chemical binding]; other site 1093787000164 switch I binding region; other site 1093787000165 ADP-ribosyltransferase exoenzyme; Region: ADPrib_exo_Tox; pfam03496 1093787000166 active site 1093787000167 conformational flexibility of ligand binding pocket; other site 1093787000168 ADP-ribosylating toxin turn-turn motif; other site 1093787000169 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 1093787000170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 1093787000171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 1093787000172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1093787000173 sequence-specific DNA binding site [nucleotide binding]; other site 1093787000174 salt bridge; other site 1093787000175 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1093787000176 active site 1093787000177 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1093787000178 dimer interface [polypeptide binding]; other site 1093787000179 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1093787000180 Ligand Binding Site [chemical binding]; other site 1093787000181 Molecular Tunnel; other site 1093787000182 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1093787000183 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 1093787000184 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1093787000185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3812 1093787000186 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787000187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787000188 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1093787000189 putative effector binding pocket; other site 1093787000190 dimerization interface [polypeptide binding]; other site 1093787000191 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1093787000192 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1093787000193 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1093787000194 catalytic residues [active] 1093787000195 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1093787000196 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1093787000197 Predicted aminopeptidase [General function prediction only]; Region: COG4324 1093787000198 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1093787000199 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1093787000200 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1093787000201 motif II; other site 1093787000202 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1093787000203 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1093787000204 trimer interface [polypeptide binding]; other site 1093787000205 putative metal binding site [ion binding]; other site 1093787000206 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1093787000207 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1093787000208 active site 1093787000209 Zn binding site [ion binding]; other site 1093787000210 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 1093787000211 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1093787000212 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1093787000213 FeS/SAM binding site; other site 1093787000214 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1093787000215 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1093787000216 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1093787000217 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1093787000218 Walker A/P-loop; other site 1093787000219 ATP binding site [chemical binding]; other site 1093787000220 Q-loop/lid; other site 1093787000221 ABC transporter signature motif; other site 1093787000222 Walker B; other site 1093787000223 D-loop; other site 1093787000224 H-loop/switch region; other site 1093787000225 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1093787000226 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1093787000227 active site 1093787000228 ATP binding site [chemical binding]; other site 1093787000229 substrate binding site [chemical binding]; other site 1093787000230 activation loop (A-loop); other site 1093787000231 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1093787000232 metal ion-dependent adhesion site (MIDAS); other site 1093787000233 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1093787000234 active site 1093787000235 Protein phosphatase 2C; Region: PP2C; pfam00481 1093787000236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SciT; COG3913 1093787000237 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1093787000238 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1093787000239 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1093787000240 hypothetical protein; Provisional; Region: PRK07033 1093787000241 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 1093787000242 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1093787000243 ligand binding site [chemical binding]; other site 1093787000244 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 1093787000245 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1093787000246 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 1093787000247 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1093787000248 phosphopeptide binding site; other site 1093787000249 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 1093787000250 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1093787000251 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1093787000252 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 1093787000253 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1093787000254 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1093787000255 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1093787000256 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 1093787000257 ImpE protein; Region: ImpE; pfam07024 1093787000258 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 1093787000259 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1093787000260 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1093787000261 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 1093787000262 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1093787000263 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787000264 Walker A motif; other site 1093787000265 ATP binding site [chemical binding]; other site 1093787000266 Walker B motif; other site 1093787000267 arginine finger; other site 1093787000268 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787000269 Walker A motif; other site 1093787000270 ATP binding site [chemical binding]; other site 1093787000271 Walker B motif; other site 1093787000272 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1093787000273 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1093787000274 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1093787000275 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1093787000276 PAAR motif; Region: PAAR_motif; pfam05488 1093787000277 Uncharacterized conserved protein [Function unknown]; Region: COG5435 1093787000278 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1093787000279 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1093787000280 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1093787000281 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1093787000282 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1093787000283 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 1093787000284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5351 1093787000285 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 1093787000286 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1093787000287 active site 1093787000288 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1093787000289 conserved hypothetical protein; Region: TIGR02270 1093787000290 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1093787000291 active site clefts [active] 1093787000292 zinc binding site [ion binding]; other site 1093787000293 dimer interface [polypeptide binding]; other site 1093787000294 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1093787000295 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1093787000296 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1093787000297 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1093787000298 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1093787000299 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1093787000300 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1093787000301 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1093787000302 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1093787000303 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1093787000304 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1093787000305 Subunit I/III interface [polypeptide binding]; other site 1093787000306 D-pathway; other site 1093787000307 Subunit I/VIIc interface [polypeptide binding]; other site 1093787000308 Subunit I/IV interface [polypeptide binding]; other site 1093787000309 Subunit I/II interface [polypeptide binding]; other site 1093787000310 Low-spin heme (heme a) binding site [chemical binding]; other site 1093787000311 Subunit I/VIIa interface [polypeptide binding]; other site 1093787000312 Subunit I/VIa interface [polypeptide binding]; other site 1093787000313 Dimer interface; other site 1093787000314 Putative water exit pathway; other site 1093787000315 Binuclear center (heme a3/CuB) [ion binding]; other site 1093787000316 K-pathway; other site 1093787000317 Subunit I/Vb interface [polypeptide binding]; other site 1093787000318 Putative proton exit pathway; other site 1093787000319 Subunit I/VIb interface; other site 1093787000320 Subunit I/VIc interface [polypeptide binding]; other site 1093787000321 Electron transfer pathway; other site 1093787000322 Subunit I/VIIIb interface [polypeptide binding]; other site 1093787000323 Subunit I/VIIb interface [polypeptide binding]; other site 1093787000324 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 1093787000325 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 1093787000326 Subunit III/VIIa interface [polypeptide binding]; other site 1093787000327 Phospholipid binding site [chemical binding]; other site 1093787000328 Subunit I/III interface [polypeptide binding]; other site 1093787000329 Subunit III/VIb interface [polypeptide binding]; other site 1093787000330 Subunit III/VIa interface; other site 1093787000331 Subunit III/Vb interface [polypeptide binding]; other site 1093787000332 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 1093787000333 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1093787000334 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1093787000335 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1093787000336 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1093787000337 UbiA prenyltransferase family; Region: UbiA; pfam01040 1093787000338 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1093787000339 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1093787000340 Cu(I) binding site [ion binding]; other site 1093787000341 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1093787000342 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787000343 Coenzyme A binding pocket [chemical binding]; other site 1093787000344 Predicted transcriptional regulators [Transcription]; Region: COG1733 1093787000345 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1093787000346 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1093787000347 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 1093787000348 putative NAD(P) binding site [chemical binding]; other site 1093787000349 active site 1093787000350 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 1093787000351 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1093787000352 putative catalytic residue [active] 1093787000353 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 1093787000354 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1093787000355 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1093787000356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787000357 DNA-binding site [nucleotide binding]; DNA binding site 1093787000358 FCD domain; Region: FCD; pfam07729 1093787000359 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1093787000360 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1093787000361 DNA-binding site [nucleotide binding]; DNA binding site 1093787000362 FCD domain; Region: FCD; pfam07729 1093787000363 Aegerolysin; Region: Aegerolysin; pfam06355 1093787000364 transcriptional regulator; Provisional; Region: PRK10632 1093787000365 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787000366 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1093787000367 putative effector binding pocket; other site 1093787000368 dimerization interface [polypeptide binding]; other site 1093787000369 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1093787000370 Predicted transcriptional regulator [Transcription]; Region: COG3905 1093787000371 Water Stress and Hypersensitive response; Region: WHy; smart00769 1093787000372 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1093787000373 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1093787000374 PhnA protein; Region: PhnA; pfam03831 1093787000375 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1093787000376 Spore germination protein; Region: Spore_permease; cl17796 1093787000377 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1093787000378 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1093787000379 tetrameric interface [polypeptide binding]; other site 1093787000380 NAD binding site [chemical binding]; other site 1093787000381 catalytic residues [active] 1093787000382 Cupin domain; Region: Cupin_2; cl17218 1093787000383 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1093787000384 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1093787000385 inhibitor-cofactor binding pocket; inhibition site 1093787000386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787000387 catalytic residue [active] 1093787000388 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787000389 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787000390 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1093787000391 dimerization interface [polypeptide binding]; other site 1093787000392 guanine deaminase; Provisional; Region: PRK09228 1093787000393 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1093787000394 active site 1093787000395 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1093787000396 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1093787000397 Walker A/P-loop; other site 1093787000398 ATP binding site [chemical binding]; other site 1093787000399 Q-loop/lid; other site 1093787000400 ABC transporter signature motif; other site 1093787000401 Walker B; other site 1093787000402 D-loop; other site 1093787000403 H-loop/switch region; other site 1093787000404 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1093787000405 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1093787000406 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1093787000407 TM-ABC transporter signature motif; other site 1093787000408 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1093787000409 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1093787000410 TM-ABC transporter signature motif; other site 1093787000411 peroxiredoxin; Region: AhpC; TIGR03137 1093787000412 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1093787000413 dimer interface [polypeptide binding]; other site 1093787000414 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1093787000415 catalytic triad [active] 1093787000416 peroxidatic and resolving cysteines [active] 1093787000417 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1093787000418 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1093787000419 catalytic residue [active] 1093787000420 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1093787000421 catalytic residues [active] 1093787000422 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1093787000423 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1093787000424 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1093787000425 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 1093787000426 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1093787000427 active site 1093787000428 putative substrate binding pocket [chemical binding]; other site 1093787000429 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1093787000430 active site 1093787000431 tetramer interface [polypeptide binding]; other site 1093787000432 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 1093787000433 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 1093787000434 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1093787000435 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1093787000436 putative ligand binding site [chemical binding]; other site 1093787000437 oxidase reductase; Provisional; Region: PTZ00273 1093787000438 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1093787000439 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1093787000440 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1093787000441 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1093787000442 active site 1093787000443 purine riboside binding site [chemical binding]; other site 1093787000444 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1093787000445 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1093787000446 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1093787000447 DNA binding residues [nucleotide binding] 1093787000448 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1093787000449 FecR protein; Region: FecR; pfam04773 1093787000450 Secretin and TonB N terminus short domain; Region: STN; smart00965 1093787000451 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1093787000452 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787000453 N-terminal plug; other site 1093787000454 ligand-binding site [chemical binding]; other site 1093787000455 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1093787000456 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787000457 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787000458 dimerization interface [polypeptide binding]; other site 1093787000459 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 1093787000460 heterodimer interface [polypeptide binding]; other site 1093787000461 multimer interface [polypeptide binding]; other site 1093787000462 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1093787000463 active site 1093787000464 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1093787000465 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1093787000466 heterodimer interface [polypeptide binding]; other site 1093787000467 active site 1093787000468 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1093787000469 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1093787000470 Bacterial transcriptional regulator; Region: IclR; pfam01614 1093787000471 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1093787000472 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787000473 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787000474 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1093787000475 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787000476 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787000477 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1093787000478 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787000479 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787000480 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1093787000481 putative effector binding pocket; other site 1093787000482 dimerization interface [polypeptide binding]; other site 1093787000483 outer membrane porin, OprD family; Region: OprD; pfam03573 1093787000484 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1093787000485 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787000486 Helix-turn-helix domain; Region: HTH_18; pfam12833 1093787000487 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1093787000488 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1093787000489 Nucleoside-binding outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: Tsx; COG3248 1093787000490 xanthine permease; Region: pbuX; TIGR03173 1093787000491 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787000492 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1093787000493 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1093787000494 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1093787000495 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1093787000496 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787000497 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787000498 metal binding site [ion binding]; metal-binding site 1093787000499 active site 1093787000500 I-site; other site 1093787000501 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 1093787000502 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787000503 dimerization interface [polypeptide binding]; other site 1093787000504 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1093787000505 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1093787000506 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1093787000507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787000508 active site 1093787000509 phosphorylation site [posttranslational modification] 1093787000510 intermolecular recognition site; other site 1093787000511 dimerization interface [polypeptide binding]; other site 1093787000512 CheB methylesterase; Region: CheB_methylest; pfam01339 1093787000513 CheD chemotactic sensory transduction; Region: CheD; cl00810 1093787000514 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1093787000515 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1093787000516 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1093787000517 PAS domain; Region: PAS; smart00091 1093787000518 PAS domain; Region: PAS_9; pfam13426 1093787000519 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1093787000520 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787000521 dimer interface [polypeptide binding]; other site 1093787000522 putative CheW interface [polypeptide binding]; other site 1093787000523 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1093787000524 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1093787000525 putative binding surface; other site 1093787000526 active site 1093787000527 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1093787000528 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1093787000529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787000530 ATP binding site [chemical binding]; other site 1093787000531 G-X-G motif; other site 1093787000532 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1093787000533 Response regulator receiver domain; Region: Response_reg; pfam00072 1093787000534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787000535 active site 1093787000536 phosphorylation site [posttranslational modification] 1093787000537 intermolecular recognition site; other site 1093787000538 dimerization interface [polypeptide binding]; other site 1093787000539 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1093787000540 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787000541 putative CheW interface [polypeptide binding]; other site 1093787000542 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787000543 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787000544 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1093787000545 putative effector binding pocket; other site 1093787000546 dimerization interface [polypeptide binding]; other site 1093787000547 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1093787000548 classical (c) SDRs; Region: SDR_c; cd05233 1093787000549 NAD(P) binding site [chemical binding]; other site 1093787000550 active site 1093787000551 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1093787000552 Sulfatase; Region: Sulfatase; pfam00884 1093787000553 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1093787000554 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1093787000555 Walker A/P-loop; other site 1093787000556 ATP binding site [chemical binding]; other site 1093787000557 Q-loop/lid; other site 1093787000558 ABC transporter signature motif; other site 1093787000559 Walker B; other site 1093787000560 D-loop; other site 1093787000561 H-loop/switch region; other site 1093787000562 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1093787000563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1093787000564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1093787000565 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1093787000566 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1093787000567 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1093787000568 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1093787000569 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1093787000570 substrate binding pocket [chemical binding]; other site 1093787000571 active site 1093787000572 iron coordination sites [ion binding]; other site 1093787000573 Predicted permeases [General function prediction only]; Region: COG0679 1093787000574 outer membrane porin, OprD family; Region: OprD; pfam03573 1093787000575 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1093787000576 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1093787000577 active site 1093787000578 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787000579 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787000580 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1093787000581 dimerization interface [polypeptide binding]; other site 1093787000582 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1093787000583 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787000584 N-terminal plug; other site 1093787000585 ligand-binding site [chemical binding]; other site 1093787000586 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1093787000587 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1093787000588 active site 1093787000589 iron coordination sites [ion binding]; other site 1093787000590 substrate binding pocket [chemical binding]; other site 1093787000591 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1093787000592 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1093787000593 active site 1093787000594 iron coordination sites [ion binding]; other site 1093787000595 substrate binding pocket [chemical binding]; other site 1093787000596 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1093787000597 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1093787000598 ligand binding site [chemical binding]; other site 1093787000599 homodimer interface [polypeptide binding]; other site 1093787000600 NAD(P) binding site [chemical binding]; other site 1093787000601 trimer interface B [polypeptide binding]; other site 1093787000602 trimer interface A [polypeptide binding]; other site 1093787000603 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1093787000604 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1093787000605 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1093787000606 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1093787000607 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1093787000608 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1093787000609 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1093787000610 TolR protein; Region: tolR; TIGR02801 1093787000611 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 1093787000612 Serine hydrolase; Region: Ser_hydrolase; pfam06821 1093787000613 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1093787000614 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 1093787000615 Coenzyme A transferase; Region: CoA_trans; cl17247 1093787000616 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1093787000617 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 1093787000618 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 1093787000619 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 1093787000620 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 1093787000621 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833 1093787000622 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 1093787000623 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 1093787000624 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1093787000625 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 1093787000626 Malonate transporter MadL subunit; Region: MadL; cl04273 1093787000627 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 1093787000628 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787000629 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787000630 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 1093787000631 putative dimerization interface [polypeptide binding]; other site 1093787000632 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787000633 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787000634 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1093787000635 putative substrate binding pocket [chemical binding]; other site 1093787000636 dimerization interface [polypeptide binding]; other site 1093787000637 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1093787000638 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1093787000639 NAD(P) binding site [chemical binding]; other site 1093787000640 catalytic residues [active] 1093787000641 amino acid transporter; Region: 2A0306; TIGR00909 1093787000642 putative aminotransferase; Provisional; Region: PRK12403 1093787000643 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1093787000644 inhibitor-cofactor binding pocket; inhibition site 1093787000645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787000646 catalytic residue [active] 1093787000647 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1093787000648 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1093787000649 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1093787000650 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1093787000651 inhibitor site; inhibition site 1093787000652 active site 1093787000653 dimer interface [polypeptide binding]; other site 1093787000654 catalytic residue [active] 1093787000655 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 1093787000656 intersubunit interface [polypeptide binding]; other site 1093787000657 active site 1093787000658 Zn2+ binding site [ion binding]; other site 1093787000659 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1093787000660 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1093787000661 sequence-specific DNA binding site [nucleotide binding]; other site 1093787000662 salt bridge; other site 1093787000663 Cupin domain; Region: Cupin_2; pfam07883 1093787000664 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1093787000665 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 1093787000666 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1093787000667 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1093787000668 dimer interface [polypeptide binding]; other site 1093787000669 active site 1093787000670 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1093787000671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787000672 putative substrate translocation pore; other site 1093787000673 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 1093787000674 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1093787000675 tetramer interface [polypeptide binding]; other site 1093787000676 active site 1093787000677 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1093787000678 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 1093787000679 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787000680 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787000681 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787000682 dimerization interface [polypeptide binding]; other site 1093787000683 benzoate transport; Region: 2A0115; TIGR00895 1093787000684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787000685 putative substrate translocation pore; other site 1093787000686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787000687 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1093787000688 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1093787000689 Bacterial transcriptional regulator; Region: IclR; pfam01614 1093787000690 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1093787000691 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1093787000692 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1093787000693 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1093787000694 EamA-like transporter family; Region: EamA; pfam00892 1093787000695 outer membrane porin, OprD family; Region: OprD; pfam03573 1093787000696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787000697 D-galactonate transporter; Region: 2A0114; TIGR00893 1093787000698 putative substrate translocation pore; other site 1093787000699 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1093787000700 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1093787000701 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1093787000702 dimer interface [polypeptide binding]; other site 1093787000703 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1093787000704 active site 1093787000705 Fe binding site [ion binding]; other site 1093787000706 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787000707 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787000708 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 1093787000709 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1093787000710 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1093787000711 shikimate binding site; other site 1093787000712 NAD(P) binding site [chemical binding]; other site 1093787000713 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1093787000714 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1093787000715 active site 1093787000716 trimer interface [polypeptide binding]; other site 1093787000717 dimer interface [polypeptide binding]; other site 1093787000718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787000719 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1093787000720 putative substrate translocation pore; other site 1093787000721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787000722 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1093787000723 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1093787000724 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1093787000725 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1093787000726 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787000727 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787000728 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1093787000729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787000730 Coenzyme A binding pocket [chemical binding]; other site 1093787000731 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1093787000732 FOG: CBS domain [General function prediction only]; Region: COG0517 1093787000733 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1093787000734 MarR family; Region: MarR_2; cl17246 1093787000735 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1093787000736 Predicted membrane protein [Function unknown]; Region: COG3619 1093787000737 Integrase core domain; Region: rve_3; pfam13683 1093787000738 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 1093787000739 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 1093787000740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 1093787000741 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1093787000742 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1093787000743 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1093787000744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 1093787000745 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1093787000746 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1093787000747 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1093787000748 tetramerization interface [polypeptide binding]; other site 1093787000749 NAD(P) binding site [chemical binding]; other site 1093787000750 catalytic residues [active] 1093787000751 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 1093787000752 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1093787000753 inhibitor-cofactor binding pocket; inhibition site 1093787000754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787000755 catalytic residue [active] 1093787000756 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1093787000757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787000758 active site 1093787000759 phosphorylation site [posttranslational modification] 1093787000760 intermolecular recognition site; other site 1093787000761 dimerization interface [polypeptide binding]; other site 1093787000762 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1093787000763 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787000764 DNA-binding site [nucleotide binding]; DNA binding site 1093787000765 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1093787000766 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1093787000767 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787000768 homodimer interface [polypeptide binding]; other site 1093787000769 catalytic residue [active] 1093787000770 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1093787000771 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1093787000772 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1093787000773 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1093787000774 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787000775 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787000776 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1093787000777 substrate binding pocket [chemical binding]; other site 1093787000778 dimerization interface [polypeptide binding]; other site 1093787000779 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1093787000780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787000781 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1093787000782 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1093787000783 ligand binding site [chemical binding]; other site 1093787000784 flexible hinge region; other site 1093787000785 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1093787000786 Predicted membrane protein [Function unknown]; Region: COG4539 1093787000787 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1093787000788 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1093787000789 dimerization interface [polypeptide binding]; other site 1093787000790 putative DNA binding site [nucleotide binding]; other site 1093787000791 putative Zn2+ binding site [ion binding]; other site 1093787000792 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1093787000793 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1093787000794 Walker A/P-loop; other site 1093787000795 ATP binding site [chemical binding]; other site 1093787000796 Q-loop/lid; other site 1093787000797 ABC transporter signature motif; other site 1093787000798 Walker B; other site 1093787000799 D-loop; other site 1093787000800 H-loop/switch region; other site 1093787000801 TOBE-like domain; Region: TOBE_3; pfam12857 1093787000802 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1093787000803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787000804 dimer interface [polypeptide binding]; other site 1093787000805 conserved gate region; other site 1093787000806 putative PBP binding loops; other site 1093787000807 ABC-ATPase subunit interface; other site 1093787000808 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1093787000809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787000810 dimer interface [polypeptide binding]; other site 1093787000811 conserved gate region; other site 1093787000812 putative PBP binding loops; other site 1093787000813 ABC-ATPase subunit interface; other site 1093787000814 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1093787000815 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1093787000816 Uncharacterized small protein [Function unknown]; Region: COG5583 1093787000817 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787000818 PAS fold; Region: PAS_3; pfam08447 1093787000819 putative active site [active] 1093787000820 heme pocket [chemical binding]; other site 1093787000821 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787000822 PAS domain; Region: PAS_9; pfam13426 1093787000823 putative active site [active] 1093787000824 heme pocket [chemical binding]; other site 1093787000825 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787000826 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787000827 metal binding site [ion binding]; metal-binding site 1093787000828 active site 1093787000829 I-site; other site 1093787000830 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1093787000831 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1093787000832 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1093787000833 Di-iron ligands [ion binding]; other site 1093787000834 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1093787000835 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1093787000836 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 1093787000837 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1093787000838 Na binding site [ion binding]; other site 1093787000839 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1093787000840 agmatinase; Region: agmatinase; TIGR01230 1093787000841 oligomer interface [polypeptide binding]; other site 1093787000842 putative active site [active] 1093787000843 Mn binding site [ion binding]; other site 1093787000844 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787000845 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787000846 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1093787000847 dimerization interface [polypeptide binding]; other site 1093787000848 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787000849 PAS fold; Region: PAS_3; pfam08447 1093787000850 putative active site [active] 1093787000851 heme pocket [chemical binding]; other site 1093787000852 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787000853 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787000854 metal binding site [ion binding]; metal-binding site 1093787000855 active site 1093787000856 I-site; other site 1093787000857 outer membrane porin, OprD family; Region: OprD; pfam03573 1093787000858 agmatine deiminase; Provisional; Region: PRK13551 1093787000859 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1093787000860 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 1093787000861 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1093787000862 putative active site; other site 1093787000863 catalytic triad [active] 1093787000864 putative dimer interface [polypeptide binding]; other site 1093787000865 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787000866 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787000867 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1093787000868 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1093787000869 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1093787000870 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1093787000871 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1093787000872 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1093787000873 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1093787000874 catalytic triad [active] 1093787000875 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1093787000876 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1093787000877 putative aminotransferase; Validated; Region: PRK07480 1093787000878 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1093787000879 inhibitor-cofactor binding pocket; inhibition site 1093787000880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787000881 catalytic residue [active] 1093787000882 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1093787000883 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1093787000884 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1093787000885 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1093787000886 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1093787000887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787000888 Walker A/P-loop; other site 1093787000889 ATP binding site [chemical binding]; other site 1093787000890 Q-loop/lid; other site 1093787000891 ABC transporter signature motif; other site 1093787000892 Walker B; other site 1093787000893 D-loop; other site 1093787000894 H-loop/switch region; other site 1093787000895 TOBE domain; Region: TOBE_2; pfam08402 1093787000896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787000897 dimer interface [polypeptide binding]; other site 1093787000898 conserved gate region; other site 1093787000899 putative PBP binding loops; other site 1093787000900 ABC-ATPase subunit interface; other site 1093787000901 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1093787000902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787000903 dimer interface [polypeptide binding]; other site 1093787000904 conserved gate region; other site 1093787000905 putative PBP binding loops; other site 1093787000906 ABC-ATPase subunit interface; other site 1093787000907 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1093787000908 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1093787000909 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1093787000910 active site 1093787000911 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1093787000912 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1093787000913 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1093787000914 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1093787000915 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1093787000916 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 1093787000917 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 1093787000918 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1093787000919 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1093787000920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787000921 dimer interface [polypeptide binding]; other site 1093787000922 conserved gate region; other site 1093787000923 putative PBP binding loops; other site 1093787000924 ABC-ATPase subunit interface; other site 1093787000925 cystine transporter subunit; Provisional; Region: PRK11260 1093787000926 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787000927 substrate binding pocket [chemical binding]; other site 1093787000928 membrane-bound complex binding site; other site 1093787000929 hinge residues; other site 1093787000930 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 1093787000931 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1093787000932 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1093787000933 ligand binding site [chemical binding]; other site 1093787000934 NAD binding site [chemical binding]; other site 1093787000935 tetramer interface [polypeptide binding]; other site 1093787000936 catalytic site [active] 1093787000937 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1093787000938 L-serine binding site [chemical binding]; other site 1093787000939 ACT domain interface; other site 1093787000940 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1093787000941 FAD binding domain; Region: FAD_binding_4; pfam01565 1093787000942 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1093787000943 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1093787000944 SdiA-regulated; Region: SdiA-regulated; pfam06977 1093787000945 SdiA-regulated; Region: SdiA-regulated; cd09971 1093787000946 putative active site [active] 1093787000947 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 1093787000948 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1093787000949 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1093787000950 active site 1093787000951 Zn binding site [ion binding]; other site 1093787000952 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1093787000953 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1093787000954 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1093787000955 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1093787000956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787000957 dimer interface [polypeptide binding]; other site 1093787000958 conserved gate region; other site 1093787000959 putative PBP binding loops; other site 1093787000960 ABC-ATPase subunit interface; other site 1093787000961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787000962 dimer interface [polypeptide binding]; other site 1093787000963 conserved gate region; other site 1093787000964 putative PBP binding loops; other site 1093787000965 ABC-ATPase subunit interface; other site 1093787000966 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1093787000967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787000968 Walker A/P-loop; other site 1093787000969 ATP binding site [chemical binding]; other site 1093787000970 Q-loop/lid; other site 1093787000971 ABC transporter signature motif; other site 1093787000972 Walker B; other site 1093787000973 D-loop; other site 1093787000974 H-loop/switch region; other site 1093787000975 TOBE domain; Region: TOBE_2; pfam08402 1093787000976 SdiA-regulated; Region: SdiA-regulated; pfam06977 1093787000977 SdiA-regulated; Region: SdiA-regulated; cd09971 1093787000978 putative active site [active] 1093787000979 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1093787000980 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1093787000981 metal binding site [ion binding]; metal-binding site 1093787000982 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 1093787000983 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1093787000984 trimer interface [polypeptide binding]; other site 1093787000985 active site 1093787000986 substrate binding site [chemical binding]; other site 1093787000987 CoA binding site [chemical binding]; other site 1093787000988 Uncharacterized conserved protein [Function unknown]; Region: COG3422 1093787000989 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 1093787000990 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1093787000991 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1093787000992 active site 1093787000993 dimer interface [polypeptide binding]; other site 1093787000994 threonine dehydratase; Reviewed; Region: PRK09224 1093787000995 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1093787000996 tetramer interface [polypeptide binding]; other site 1093787000997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787000998 catalytic residue [active] 1093787000999 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1093787001000 putative Ile/Val binding site [chemical binding]; other site 1093787001001 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1093787001002 putative Ile/Val binding site [chemical binding]; other site 1093787001003 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 1093787001004 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 1093787001005 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1093787001006 putative NAD(P) binding site [chemical binding]; other site 1093787001007 active site 1093787001008 DoxX-like family; Region: DoxX_3; pfam13781 1093787001009 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 1093787001010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787001011 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1093787001012 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1093787001013 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1093787001014 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1093787001015 putative active site [active] 1093787001016 Ap4A binding site [chemical binding]; other site 1093787001017 nudix motif; other site 1093787001018 putative metal binding site [ion binding]; other site 1093787001019 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 1093787001020 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1093787001021 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1093787001022 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1093787001023 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1093787001024 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787001025 PAS fold; Region: PAS_3; pfam08447 1093787001026 putative active site [active] 1093787001027 heme pocket [chemical binding]; other site 1093787001028 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787001029 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787001030 metal binding site [ion binding]; metal-binding site 1093787001031 active site 1093787001032 I-site; other site 1093787001033 NRDE protein; Region: NRDE; cl01315 1093787001034 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1093787001035 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1093787001036 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1093787001037 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1093787001038 dimerization interface [polypeptide binding]; other site 1093787001039 active site 1093787001040 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1093787001041 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1093787001042 G1 box; other site 1093787001043 GTP/Mg2+ binding site [chemical binding]; other site 1093787001044 G2 box; other site 1093787001045 Switch I region; other site 1093787001046 G3 box; other site 1093787001047 Switch II region; other site 1093787001048 G4 box; other site 1093787001049 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 1093787001050 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 1093787001051 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1093787001052 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 1093787001053 putative active site [active] 1093787001054 catalytic site [active] 1093787001055 putative metal binding site [ion binding]; other site 1093787001056 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1093787001057 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1093787001058 folate binding site [chemical binding]; other site 1093787001059 NADP+ binding site [chemical binding]; other site 1093787001060 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1093787001061 active site 1093787001062 metal binding site [ion binding]; metal-binding site 1093787001063 homotetramer interface [polypeptide binding]; other site 1093787001064 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1093787001065 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1093787001066 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1093787001067 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1093787001068 putative RNA binding site [nucleotide binding]; other site 1093787001069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787001070 S-adenosylmethionine binding site [chemical binding]; other site 1093787001071 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1093787001072 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1093787001073 proposed catalytic triad [active] 1093787001074 conserved cys residue [active] 1093787001075 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1093787001076 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1093787001077 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1093787001078 DNA binding site [nucleotide binding] 1093787001079 catalytic residue [active] 1093787001080 H2TH interface [polypeptide binding]; other site 1093787001081 putative catalytic residues [active] 1093787001082 turnover-facilitating residue; other site 1093787001083 intercalation triad [nucleotide binding]; other site 1093787001084 8OG recognition residue [nucleotide binding]; other site 1093787001085 putative reading head residues; other site 1093787001086 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1093787001087 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1093787001088 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1093787001089 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 1093787001090 putative acyl-acceptor binding pocket; other site 1093787001091 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1093787001092 Sel1-like repeats; Region: SEL1; smart00671 1093787001093 Sel1-like repeats; Region: SEL1; smart00671 1093787001094 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1093787001095 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1093787001096 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1093787001097 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1093787001098 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1093787001099 active site 1093787001100 (T/H)XGH motif; other site 1093787001101 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1093787001102 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1093787001103 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1093787001104 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1093787001105 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 1093787001106 NAD(P) binding site [chemical binding]; other site 1093787001107 catalytic residues [active] 1093787001108 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787001109 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787001110 Bacterial transcriptional repressor; Region: TetR; pfam13972 1093787001111 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787001112 Coenzyme A binding pocket [chemical binding]; other site 1093787001113 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1093787001114 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1093787001115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787001116 S-adenosylmethionine binding site [chemical binding]; other site 1093787001117 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1093787001118 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1093787001119 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1093787001120 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1093787001121 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1093787001122 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1093787001123 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1093787001124 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1093787001125 P loop; other site 1093787001126 GTP binding site [chemical binding]; other site 1093787001127 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1093787001128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787001129 Walker A/P-loop; other site 1093787001130 ATP binding site [chemical binding]; other site 1093787001131 Q-loop/lid; other site 1093787001132 ABC transporter signature motif; other site 1093787001133 Walker B; other site 1093787001134 D-loop; other site 1093787001135 H-loop/switch region; other site 1093787001136 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1093787001137 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1093787001138 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1093787001139 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1093787001140 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1093787001141 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1093787001142 DNA binding residues [nucleotide binding] 1093787001143 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1093787001144 monofunctional biosynthetic peptidoglycan transglycosylase; Region: mono_pep_trsgly; TIGR02070 1093787001145 Protein of unknown function (DUF423); Region: DUF423; pfam04241 1093787001146 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1093787001147 thiS-thiF/thiG interaction site; other site 1093787001148 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1093787001149 ThiS interaction site; other site 1093787001150 putative active site [active] 1093787001151 tetramer interface [polypeptide binding]; other site 1093787001152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787001153 S-adenosylmethionine binding site [chemical binding]; other site 1093787001154 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1093787001155 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 1093787001156 HemN family oxidoreductase; Provisional; Region: PRK05660 1093787001157 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1093787001158 FeS/SAM binding site; other site 1093787001159 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1093787001160 active site 1093787001161 dimerization interface [polypeptide binding]; other site 1093787001162 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 1093787001163 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1093787001164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787001165 S-adenosylmethionine binding site [chemical binding]; other site 1093787001166 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1093787001167 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1093787001168 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1093787001169 G1 box; other site 1093787001170 GTP/Mg2+ binding site [chemical binding]; other site 1093787001171 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1093787001172 G2 box; other site 1093787001173 Switch I region; other site 1093787001174 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1093787001175 G3 box; other site 1093787001176 Switch II region; other site 1093787001177 GTP/Mg2+ binding site [chemical binding]; other site 1093787001178 G4 box; other site 1093787001179 G5 box; other site 1093787001180 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 1093787001181 YGGT family; Region: YGGT; pfam02325 1093787001182 YGGT family; Region: YGGT; pfam02325 1093787001183 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1093787001184 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1093787001185 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1093787001186 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1093787001187 catalytic residue [active] 1093787001188 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1093787001189 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1093787001190 Walker A motif; other site 1093787001191 ATP binding site [chemical binding]; other site 1093787001192 Walker B motif; other site 1093787001193 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 1093787001194 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1093787001195 Walker A motif; other site 1093787001196 ATP binding site [chemical binding]; other site 1093787001197 Walker B motif; other site 1093787001198 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1093787001199 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1093787001200 TM2 domain; Region: TM2; cl00984 1093787001201 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1093787001202 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1093787001203 dimer interface [polypeptide binding]; other site 1093787001204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787001205 catalytic residue [active] 1093787001206 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1093787001207 FOG: CBS domain [General function prediction only]; Region: COG0517 1093787001208 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1093787001209 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1093787001210 homodimer interface [polypeptide binding]; other site 1093787001211 substrate-cofactor binding pocket; other site 1093787001212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787001213 catalytic residue [active] 1093787001214 dihydroorotase; Validated; Region: pyrC; PRK09357 1093787001215 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1093787001216 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1093787001217 active site 1093787001218 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1093787001219 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1093787001220 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1093787001221 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1093787001222 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1093787001223 active site 1093787001224 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1093787001225 hypothetical protein; Validated; Region: PRK00228 1093787001226 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1093787001227 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1093787001228 glutathione synthetase; Provisional; Region: PRK05246 1093787001229 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1093787001230 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1093787001231 Response regulator receiver domain; Region: Response_reg; pfam00072 1093787001232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787001233 active site 1093787001234 phosphorylation site [posttranslational modification] 1093787001235 intermolecular recognition site; other site 1093787001236 dimerization interface [polypeptide binding]; other site 1093787001237 Response regulator receiver domain; Region: Response_reg; pfam00072 1093787001238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787001239 active site 1093787001240 phosphorylation site [posttranslational modification] 1093787001241 intermolecular recognition site; other site 1093787001242 dimerization interface [polypeptide binding]; other site 1093787001243 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1093787001244 putative CheA interaction surface; other site 1093787001245 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1093787001246 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1093787001247 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787001248 dimer interface [polypeptide binding]; other site 1093787001249 putative CheW interface [polypeptide binding]; other site 1093787001250 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1093787001251 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1093787001252 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1093787001253 Hpt domain; Region: Hpt; pfam01627 1093787001254 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1093787001255 putative binding surface; other site 1093787001256 active site 1093787001257 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1093787001258 putative binding surface; other site 1093787001259 active site 1093787001260 Hpt domain; Region: Hpt; pfam01627 1093787001261 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1093787001262 putative binding surface; other site 1093787001263 active site 1093787001264 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1093787001265 putative binding surface; other site 1093787001266 active site 1093787001267 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1093787001268 putative binding surface; other site 1093787001269 active site 1093787001270 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1093787001271 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1093787001272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787001273 ATP binding site [chemical binding]; other site 1093787001274 Mg2+ binding site [ion binding]; other site 1093787001275 G-X-G motif; other site 1093787001276 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1093787001277 Response regulator receiver domain; Region: Response_reg; pfam00072 1093787001278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787001279 active site 1093787001280 phosphorylation site [posttranslational modification] 1093787001281 intermolecular recognition site; other site 1093787001282 dimerization interface [polypeptide binding]; other site 1093787001283 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1093787001284 CheB methylesterase; Region: CheB_methylest; pfam01339 1093787001285 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1093787001286 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1093787001287 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787001288 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787001289 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787001290 LysE type translocator; Region: LysE; pfam01810 1093787001291 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1093787001292 RNA methyltransferase, RsmE family; Region: TIGR00046 1093787001293 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030 1093787001294 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1093787001295 inhibitor-cofactor binding pocket; inhibition site 1093787001296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787001297 catalytic residue [active] 1093787001298 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1093787001299 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1093787001300 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1093787001301 hypothetical protein; Provisional; Region: PRK03757 1093787001302 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1093787001303 MarR family; Region: MarR; pfam01047 1093787001304 potential frameshift: common BLAST hit: gi|218889167|ref|YP_002438031.1| Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane 1093787001305 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1093787001306 Protein export membrane protein; Region: SecD_SecF; cl14618 1093787001307 Protein export membrane protein; Region: SecD_SecF; cl14618 1093787001308 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1093787001309 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1093787001310 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1093787001311 ATP binding site [chemical binding]; other site 1093787001312 Mg++ binding site [ion binding]; other site 1093787001313 motif III; other site 1093787001314 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1093787001315 nucleotide binding region [chemical binding]; other site 1093787001316 ATP-binding site [chemical binding]; other site 1093787001317 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1093787001318 FAD binding site [chemical binding]; other site 1093787001319 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1093787001320 HD domain; Region: HD_4; pfam13328 1093787001321 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1093787001322 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1093787001323 homotetramer interface [polypeptide binding]; other site 1093787001324 ligand binding site [chemical binding]; other site 1093787001325 catalytic site [active] 1093787001326 NAD binding site [chemical binding]; other site 1093787001327 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1093787001328 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787001329 N-terminal plug; other site 1093787001330 ligand-binding site [chemical binding]; other site 1093787001331 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1093787001332 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1093787001333 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1093787001334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787001335 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1093787001336 cytosine deaminase; Provisional; Region: PRK09230 1093787001337 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1093787001338 active site 1093787001339 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 1093787001340 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1093787001341 Na binding site [ion binding]; other site 1093787001342 putative substrate binding site [chemical binding]; other site 1093787001343 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1093787001344 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1093787001345 homodimer interface [polypeptide binding]; other site 1093787001346 active site 1093787001347 FMN binding site [chemical binding]; other site 1093787001348 substrate binding site [chemical binding]; other site 1093787001349 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1093787001350 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1093787001351 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1093787001352 phenylhydantoinase; Validated; Region: PRK08323 1093787001353 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1093787001354 tetramer interface [polypeptide binding]; other site 1093787001355 active site 1093787001356 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1093787001357 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1093787001358 Na binding site [ion binding]; other site 1093787001359 putative substrate binding site [chemical binding]; other site 1093787001360 allantoate amidohydrolase; Reviewed; Region: PRK09290 1093787001361 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1093787001362 active site 1093787001363 metal binding site [ion binding]; metal-binding site 1093787001364 dimer interface [polypeptide binding]; other site 1093787001365 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1093787001366 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1093787001367 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1093787001368 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1093787001369 FAD binding site [chemical binding]; other site 1093787001370 substrate binding pocket [chemical binding]; other site 1093787001371 catalytic base [active] 1093787001372 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1093787001373 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787001374 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 1093787001375 dimerization interface [polypeptide binding]; other site 1093787001376 substrate binding pocket [chemical binding]; other site 1093787001377 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1093787001378 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1093787001379 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 1093787001380 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1093787001381 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1093787001382 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 1093787001383 dimer interface [polypeptide binding]; other site 1093787001384 active site residues [active] 1093787001385 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1093787001386 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1093787001387 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1093787001388 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1093787001389 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787001390 substrate binding pocket [chemical binding]; other site 1093787001391 membrane-bound complex binding site; other site 1093787001392 hinge residues; other site 1093787001393 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1093787001394 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1093787001395 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1093787001396 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1093787001397 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1093787001398 ATP binding site [chemical binding]; other site 1093787001399 Mg++ binding site [ion binding]; other site 1093787001400 motif III; other site 1093787001401 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1093787001402 nucleotide binding region [chemical binding]; other site 1093787001403 ATP-binding site [chemical binding]; other site 1093787001404 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1093787001405 putative RNA binding site [nucleotide binding]; other site 1093787001406 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1093787001407 DNA-binding site [nucleotide binding]; DNA binding site 1093787001408 RNA-binding motif; other site 1093787001409 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1093787001410 putative transporter; Provisional; Region: PRK10504 1093787001411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787001412 putative substrate translocation pore; other site 1093787001413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787001414 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1093787001415 Clp amino terminal domain; Region: Clp_N; pfam02861 1093787001416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787001417 Walker A motif; other site 1093787001418 ATP binding site [chemical binding]; other site 1093787001419 Walker B motif; other site 1093787001420 arginine finger; other site 1093787001421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787001422 Walker A motif; other site 1093787001423 ATP binding site [chemical binding]; other site 1093787001424 Walker B motif; other site 1093787001425 arginine finger; other site 1093787001426 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1093787001427 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 1093787001428 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1093787001429 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1093787001430 putative acyl-acceptor binding pocket; other site 1093787001431 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1093787001432 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1093787001433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787001434 active site 1093787001435 phosphorylation site [posttranslational modification] 1093787001436 intermolecular recognition site; other site 1093787001437 dimerization interface [polypeptide binding]; other site 1093787001438 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787001439 DNA binding site [nucleotide binding] 1093787001440 sensory histidine kinase CreC; Provisional; Region: PRK11100 1093787001441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787001442 dimer interface [polypeptide binding]; other site 1093787001443 phosphorylation site [posttranslational modification] 1093787001444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787001445 ATP binding site [chemical binding]; other site 1093787001446 G-X-G motif; other site 1093787001447 Inner membrane protein CreD; Region: CreD; cl01844 1093787001448 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1093787001449 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1093787001450 putative C-terminal domain interface [polypeptide binding]; other site 1093787001451 putative GSH binding site (G-site) [chemical binding]; other site 1093787001452 putative dimer interface [polypeptide binding]; other site 1093787001453 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1093787001454 N-terminal domain interface [polypeptide binding]; other site 1093787001455 dimer interface [polypeptide binding]; other site 1093787001456 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1093787001457 Protein phosphatase 2C; Region: PP2C_2; pfam13672 1093787001458 Secretin and TonB N terminus short domain; Region: STN; smart00965 1093787001459 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1093787001460 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787001461 N-terminal plug; other site 1093787001462 ligand-binding site [chemical binding]; other site 1093787001463 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1093787001464 FecR protein; Region: FecR; pfam04773 1093787001465 RNA polymerase sigma factor; Reviewed; Region: PRK12523 1093787001466 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1093787001467 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1093787001468 DNA binding residues [nucleotide binding] 1093787001469 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1093787001470 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1093787001471 C-terminal domain interface [polypeptide binding]; other site 1093787001472 GSH binding site (G-site) [chemical binding]; other site 1093787001473 dimer interface [polypeptide binding]; other site 1093787001474 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1093787001475 N-terminal domain interface [polypeptide binding]; other site 1093787001476 dimer interface [polypeptide binding]; other site 1093787001477 substrate binding pocket (H-site) [chemical binding]; other site 1093787001478 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1093787001479 CoenzymeA binding site [chemical binding]; other site 1093787001480 subunit interaction site [polypeptide binding]; other site 1093787001481 PHB binding site; other site 1093787001482 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787001483 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787001484 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1093787001485 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1093787001486 Na binding site [ion binding]; other site 1093787001487 putative substrate binding site [chemical binding]; other site 1093787001488 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787001489 The C-terminal substrate biniding domain of an uncharacterized LysR-like transcriptional regulator Pa0477 related to DntR, contains the type 2 periplasmic binding fold; Region: PBP2_Pa0477; cd08468 1093787001490 putative substrate binding pocket [chemical binding]; other site 1093787001491 dimerization interface [polypeptide binding]; other site 1093787001492 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1093787001493 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787001494 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787001495 dimerization interface [polypeptide binding]; other site 1093787001496 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1093787001497 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1093787001498 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1093787001499 active site 1093787001500 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1093787001501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787001502 Coenzyme A binding pocket [chemical binding]; other site 1093787001503 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1093787001504 ACT domain; Region: ACT_6; pfam13740 1093787001505 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1093787001506 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1093787001507 EamA-like transporter family; Region: EamA; pfam00892 1093787001508 serine/threonine protein kinase; Provisional; Region: PRK11768 1093787001509 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1093787001510 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1093787001511 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1093787001512 TOBE domain; Region: TOBE; cl01440 1093787001513 TOBE domain; Region: TOBE; cl01440 1093787001514 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574 1093787001515 comF family protein; Region: comF; TIGR00201 1093787001516 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1093787001517 active site 1093787001518 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787001519 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787001520 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1093787001521 putative substrate binding pocket [chemical binding]; other site 1093787001522 dimerization interface [polypeptide binding]; other site 1093787001523 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_2; cd11664 1093787001524 putative active site [active] 1093787001525 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1093787001526 carboxyltransferase (CT) interaction site; other site 1093787001527 biotinylation site [posttranslational modification]; other site 1093787001528 acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833 1093787001529 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1093787001530 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1093787001531 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1093787001532 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1093787001533 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1093787001534 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1093787001535 Fimbrial protein; Region: Fimbrial; pfam00419 1093787001536 Fimbrial protein; Region: Fimbrial; pfam00419 1093787001537 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1093787001538 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1093787001539 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1093787001540 biotin synthase; Provisional; Region: PRK15108 1093787001541 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1093787001542 FeS/SAM binding site; other site 1093787001543 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1093787001544 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1093787001545 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1093787001546 substrate-cofactor binding pocket; other site 1093787001547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787001548 catalytic residue [active] 1093787001549 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1093787001550 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1093787001551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787001552 S-adenosylmethionine binding site [chemical binding]; other site 1093787001553 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1093787001554 AAA domain; Region: AAA_26; pfam13500 1093787001555 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1093787001556 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1093787001557 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787001558 active site 1093787001559 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1093787001560 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1093787001561 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1093787001562 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787001563 active site 1093787001564 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1093787001565 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1093787001566 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1093787001567 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787001568 active site 1093787001569 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1093787001570 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1093787001571 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1093787001572 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 1093787001573 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1093787001574 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1093787001575 active site 1093787001576 SAM binding site [chemical binding]; other site 1093787001577 homodimer interface [polypeptide binding]; other site 1093787001578 heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051 1093787001579 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1093787001580 FeS/SAM binding site; other site 1093787001581 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1093787001582 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1093787001583 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1093787001584 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1093787001585 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 1093787001586 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1093787001587 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1093787001588 Cytochrome c551/c552 [Energy production and conversion]; Region: COG4654 1093787001589 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1093787001590 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1093787001591 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 1093787001592 MoxR-like ATPases [General function prediction only]; Region: COG0714 1093787001593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787001594 Walker A motif; other site 1093787001595 ATP binding site [chemical binding]; other site 1093787001596 Walker B motif; other site 1093787001597 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1093787001598 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 1093787001599 Subunit I/III interface [polypeptide binding]; other site 1093787001600 Cytochrome c; Region: Cytochrom_C; pfam00034 1093787001601 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1093787001602 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1093787001603 Low-spin heme binding site [chemical binding]; other site 1093787001604 D-pathway; other site 1093787001605 Putative water exit pathway; other site 1093787001606 Binuclear center (active site) [active] 1093787001607 K-pathway; other site 1093787001608 Putative proton exit pathway; other site 1093787001609 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1093787001610 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1093787001611 metal ion-dependent adhesion site (MIDAS); other site 1093787001612 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1093787001613 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1093787001614 ligand binding site [chemical binding]; other site 1093787001615 flexible hinge region; other site 1093787001616 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1093787001617 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787001618 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787001619 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1093787001620 dimerization interface [polypeptide binding]; other site 1093787001621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1093787001622 MOSC domain; Region: MOSC; pfam03473 1093787001623 3-alpha domain; Region: 3-alpha; pfam03475 1093787001624 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1093787001625 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1093787001626 inhibitor-cofactor binding pocket; inhibition site 1093787001627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787001628 catalytic residue [active] 1093787001629 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1093787001630 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1093787001631 catalytic triad [active] 1093787001632 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1093787001633 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787001634 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1093787001635 putative active site [active] 1093787001636 heme pocket [chemical binding]; other site 1093787001637 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787001638 putative active site [active] 1093787001639 heme pocket [chemical binding]; other site 1093787001640 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1093787001641 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787001642 DNA binding residues [nucleotide binding] 1093787001643 dimerization interface [polypeptide binding]; other site 1093787001644 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1093787001645 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1093787001646 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1093787001647 non-specific DNA binding site [nucleotide binding]; other site 1093787001648 salt bridge; other site 1093787001649 sequence-specific DNA binding site [nucleotide binding]; other site 1093787001650 Cupin domain; Region: Cupin_2; pfam07883 1093787001651 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1093787001652 Repair protein; Region: Repair_PSII; pfam04536 1093787001653 LemA family; Region: LemA; pfam04011 1093787001654 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1093787001655 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1093787001656 EamA-like transporter family; Region: EamA; pfam00892 1093787001657 Predicted membrane protein [Function unknown]; Region: COG3686 1093787001658 Cytochrome c556 [Energy production and conversion]; Region: COG3909 1093787001659 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1093787001660 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1093787001661 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1093787001662 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1093787001663 active site 1093787001664 metal binding site [ion binding]; metal-binding site 1093787001665 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 1093787001666 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1093787001667 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 1093787001668 FAD binding pocket [chemical binding]; other site 1093787001669 FAD binding motif [chemical binding]; other site 1093787001670 phosphate binding motif [ion binding]; other site 1093787001671 beta-alpha-beta structure motif; other site 1093787001672 NAD binding pocket [chemical binding]; other site 1093787001673 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1093787001674 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1093787001675 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1093787001676 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1093787001677 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1093787001678 putative DNA binding site [nucleotide binding]; other site 1093787001679 dimerization interface [polypeptide binding]; other site 1093787001680 putative Zn2+ binding site [ion binding]; other site 1093787001681 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1093787001682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787001683 S-adenosylmethionine binding site [chemical binding]; other site 1093787001684 transketolase; Reviewed; Region: PRK12753 1093787001685 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1093787001686 TPP-binding site [chemical binding]; other site 1093787001687 dimer interface [polypeptide binding]; other site 1093787001688 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1093787001689 PYR/PP interface [polypeptide binding]; other site 1093787001690 dimer interface [polypeptide binding]; other site 1093787001691 TPP binding site [chemical binding]; other site 1093787001692 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1093787001693 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1093787001694 erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532 1093787001695 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1093787001696 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1093787001697 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1093787001698 Phosphoglycerate kinase; Region: PGK; pfam00162 1093787001699 substrate binding site [chemical binding]; other site 1093787001700 hinge regions; other site 1093787001701 ADP binding site [chemical binding]; other site 1093787001702 catalytic site [active] 1093787001703 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1093787001704 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1093787001705 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1093787001706 intersubunit interface [polypeptide binding]; other site 1093787001707 active site 1093787001708 zinc binding site [ion binding]; other site 1093787001709 Na+ binding site [ion binding]; other site 1093787001710 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1093787001711 SnoaL-like domain; Region: SnoaL_3; pfam13474 1093787001712 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1093787001713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787001714 S-adenosylmethionine binding site [chemical binding]; other site 1093787001715 Predicted flavoproteins [General function prediction only]; Region: COG2081 1093787001716 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1093787001717 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1093787001718 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1093787001719 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1093787001720 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1093787001721 motif II; other site 1093787001722 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1093787001723 Cupin; Region: Cupin_6; pfam12852 1093787001724 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787001725 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787001726 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1093787001727 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1093787001728 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1093787001729 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 1093787001730 Peptidase M60-like family; Region: M60-like; pfam13402 1093787001731 Fic family protein [Function unknown]; Region: COG3177 1093787001732 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 1093787001733 Fic/DOC family; Region: Fic; pfam02661 1093787001734 CRISPR/Cas system-associated transcriptional regulator CasRa; Region: CasRa_I-A; cd09655 1093787001735 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1093787001736 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787001737 substrate binding pocket [chemical binding]; other site 1093787001738 membrane-bound complex binding site; other site 1093787001739 hinge residues; other site 1093787001740 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787001741 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1093787001742 putative active site [active] 1093787001743 heme pocket [chemical binding]; other site 1093787001744 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787001745 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 1093787001746 putative active site [active] 1093787001747 heme pocket [chemical binding]; other site 1093787001748 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787001749 putative active site [active] 1093787001750 heme pocket [chemical binding]; other site 1093787001751 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787001752 putative active site [active] 1093787001753 heme pocket [chemical binding]; other site 1093787001754 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787001755 metal binding site [ion binding]; metal-binding site 1093787001756 active site 1093787001757 I-site; other site 1093787001758 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1093787001759 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1093787001760 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1093787001761 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1093787001762 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1093787001763 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1093787001764 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1093787001765 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1093787001766 DNA binding residues [nucleotide binding] 1093787001767 DNA primase, catalytic core; Region: dnaG; TIGR01391 1093787001768 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1093787001769 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1093787001770 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1093787001771 active site 1093787001772 metal binding site [ion binding]; metal-binding site 1093787001773 interdomain interaction site; other site 1093787001774 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1093787001775 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1093787001776 Yqey-like protein; Region: YqeY; pfam09424 1093787001777 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1093787001778 UGMP family protein; Validated; Region: PRK09604 1093787001779 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1093787001780 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1093787001781 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1093787001782 homooctamer interface [polypeptide binding]; other site 1093787001783 active site 1093787001784 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1093787001785 catalytic center binding site [active] 1093787001786 ATP binding site [chemical binding]; other site 1093787001787 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1093787001788 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1093787001789 active site 1093787001790 NTP binding site [chemical binding]; other site 1093787001791 metal binding triad [ion binding]; metal-binding site 1093787001792 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1093787001793 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1093787001794 Zn2+ binding site [ion binding]; other site 1093787001795 Mg2+ binding site [ion binding]; other site 1093787001796 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1093787001797 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1093787001798 SpoVR family protein; Provisional; Region: PRK11767 1093787001799 hypothetical protein; Provisional; Region: PRK05325 1093787001800 PrkA family serine protein kinase; Provisional; Region: PRK15455 1093787001801 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1093787001802 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1093787001803 active site residue [active] 1093787001804 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1093787001805 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1093787001806 active site 1093787001807 metal binding site [ion binding]; metal-binding site 1093787001808 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1093787001809 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1093787001810 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1093787001811 S-adenosylmethionine binding site [chemical binding]; other site 1093787001812 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1093787001813 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1093787001814 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1093787001815 SurA N-terminal domain; Region: SurA_N; pfam09312 1093787001816 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1093787001817 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1093787001818 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1093787001819 OstA-like protein; Region: OstA; cl00844 1093787001820 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1093787001821 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1093787001822 Phosphotransferase enzyme family; Region: APH; pfam01636 1093787001823 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1093787001824 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1093787001825 Substrate binding site; other site 1093787001826 metal-binding site 1093787001827 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1093787001828 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 1093787001829 putative metal binding site [ion binding]; other site 1093787001830 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1093787001831 HSP70 interaction site [polypeptide binding]; other site 1093787001832 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 1093787001833 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787001834 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1093787001835 substrate binding pocket [chemical binding]; other site 1093787001836 membrane-bound complex binding site; other site 1093787001837 hinge residues; other site 1093787001838 PAS domain S-box; Region: sensory_box; TIGR00229 1093787001839 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787001840 putative active site [active] 1093787001841 heme pocket [chemical binding]; other site 1093787001842 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787001843 PAS fold; Region: PAS_3; pfam08447 1093787001844 putative active site [active] 1093787001845 heme pocket [chemical binding]; other site 1093787001846 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1093787001847 Histidine kinase; Region: HisKA_3; pfam07730 1093787001848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787001849 ATP binding site [chemical binding]; other site 1093787001850 Mg2+ binding site [ion binding]; other site 1093787001851 G-X-G motif; other site 1093787001852 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1093787001853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787001854 active site 1093787001855 phosphorylation site [posttranslational modification] 1093787001856 intermolecular recognition site; other site 1093787001857 dimerization interface [polypeptide binding]; other site 1093787001858 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787001859 DNA binding residues [nucleotide binding] 1093787001860 dimerization interface [polypeptide binding]; other site 1093787001861 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1093787001862 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1093787001863 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1093787001864 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1093787001865 Walker A/P-loop; other site 1093787001866 ATP binding site [chemical binding]; other site 1093787001867 Q-loop/lid; other site 1093787001868 ABC transporter signature motif; other site 1093787001869 Walker B; other site 1093787001870 D-loop; other site 1093787001871 H-loop/switch region; other site 1093787001872 Poxvirus L5 protein family; Region: Pox_L5; cl17406 1093787001873 TOBE domain; Region: TOBE_2; pfam08402 1093787001874 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1093787001875 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1093787001876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787001877 dimer interface [polypeptide binding]; other site 1093787001878 conserved gate region; other site 1093787001879 putative PBP binding loops; other site 1093787001880 ABC-ATPase subunit interface; other site 1093787001881 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1093787001882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787001883 dimer interface [polypeptide binding]; other site 1093787001884 conserved gate region; other site 1093787001885 putative PBP binding loops; other site 1093787001886 ABC-ATPase subunit interface; other site 1093787001887 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1093787001888 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1093787001889 substrate binding site [chemical binding]; other site 1093787001890 hexamer interface [polypeptide binding]; other site 1093787001891 metal binding site [ion binding]; metal-binding site 1093787001892 phosphoglycolate phosphatase; Provisional; Region: PRK13223 1093787001893 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1093787001894 motif II; other site 1093787001895 anthranilate synthase component I; Provisional; Region: PRK13565 1093787001896 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1093787001897 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1093787001898 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 1093787001899 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1093787001900 non-specific DNA binding site [nucleotide binding]; other site 1093787001901 Predicted transcriptional regulator [Transcription]; Region: COG2932 1093787001902 salt bridge; other site 1093787001903 sequence-specific DNA binding site [nucleotide binding]; other site 1093787001904 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1093787001905 Catalytic site [active] 1093787001906 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1093787001907 Predicted chitinase [General function prediction only]; Region: COG3179 1093787001908 catalytic residue [active] 1093787001909 Phage-related minor tail protein [Function unknown]; Region: COG5281 1093787001910 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1093787001911 Phage-related minor tail protein [Function unknown]; Region: COG5281 1093787001912 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1093787001913 Phage-related protein [Function unknown]; Region: COG4718 1093787001914 Phage-related protein [Function unknown]; Region: gp18; COG4672 1093787001915 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1093787001916 MPN+ (JAMM) motif; other site 1093787001917 Zinc-binding site [ion binding]; other site 1093787001918 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1093787001919 NlpC/P60 family; Region: NLPC_P60; pfam00877 1093787001920 Phage-related protein, tail component [Function unknown]; Region: COG4723 1093787001921 Phage-related protein, tail component [Function unknown]; Region: COG4733 1093787001922 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1093787001923 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1093787001924 Interdomain contacts; other site 1093787001925 Cytokine receptor motif; other site 1093787001926 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1093787001927 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1093787001928 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1093787001929 glutamine binding [chemical binding]; other site 1093787001930 catalytic triad [active] 1093787001931 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1093787001932 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1093787001933 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1093787001934 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1093787001935 active site 1093787001936 ribulose/triose binding site [chemical binding]; other site 1093787001937 phosphate binding site [ion binding]; other site 1093787001938 substrate (anthranilate) binding pocket [chemical binding]; other site 1093787001939 product (indole) binding pocket [chemical binding]; other site 1093787001940 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1093787001941 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1093787001942 ligand binding site [chemical binding]; other site 1093787001943 flexible hinge region; other site 1093787001944 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1093787001945 putative switch regulator; other site 1093787001946 non-specific DNA interactions [nucleotide binding]; other site 1093787001947 DNA binding site [nucleotide binding] 1093787001948 sequence specific DNA binding site [nucleotide binding]; other site 1093787001949 putative cAMP binding site [chemical binding]; other site 1093787001950 OsmC-like protein; Region: OsmC; cl00767 1093787001951 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1093787001952 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 1093787001953 diiron binding motif [ion binding]; other site 1093787001954 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1093787001955 nucleotide binding site/active site [active] 1093787001956 HIT family signature motif; other site 1093787001957 catalytic residue [active] 1093787001958 Ycf46; Provisional; Region: ycf46; CHL00195 1093787001959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787001960 Walker A motif; other site 1093787001961 ATP binding site [chemical binding]; other site 1093787001962 Walker B motif; other site 1093787001963 arginine finger; other site 1093787001964 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1093787001965 classical (c) SDRs; Region: SDR_c; cd05233 1093787001966 NAD(P) binding site [chemical binding]; other site 1093787001967 active site 1093787001968 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1093787001969 Predicted membrane protein [Function unknown]; Region: COG3152 1093787001970 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 1093787001971 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 1093787001972 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1093787001973 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1093787001974 FMN binding site [chemical binding]; other site 1093787001975 substrate binding site [chemical binding]; other site 1093787001976 putative catalytic residue [active] 1093787001977 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 1093787001978 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1093787001979 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1093787001980 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1093787001981 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1093787001982 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1093787001983 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 1093787001984 putative peptidase; Provisional; Region: PRK11649 1093787001985 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1093787001986 Peptidase family M23; Region: Peptidase_M23; pfam01551 1093787001987 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1093787001988 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1093787001989 active site 1093787001990 HIGH motif; other site 1093787001991 dimer interface [polypeptide binding]; other site 1093787001992 KMSKS motif; other site 1093787001993 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1093787001994 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1093787001995 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1093787001996 pantothenate kinase; Reviewed; Region: PRK13322 1093787001997 Sporulation related domain; Region: SPOR; pfam05036 1093787001998 Sporulation related domain; Region: SPOR; pfam05036 1093787001999 Sporulation related domain; Region: SPOR; cl10051 1093787002000 elongation factor Tu; Reviewed; Region: PRK00049 1093787002001 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1093787002002 G1 box; other site 1093787002003 GEF interaction site [polypeptide binding]; other site 1093787002004 GTP/Mg2+ binding site [chemical binding]; other site 1093787002005 Switch I region; other site 1093787002006 G2 box; other site 1093787002007 G3 box; other site 1093787002008 Switch II region; other site 1093787002009 G4 box; other site 1093787002010 G5 box; other site 1093787002011 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1093787002012 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1093787002013 Antibiotic Binding Site [chemical binding]; other site 1093787002014 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1093787002015 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1093787002016 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1093787002017 putative homodimer interface [polypeptide binding]; other site 1093787002018 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1093787002019 heterodimer interface [polypeptide binding]; other site 1093787002020 homodimer interface [polypeptide binding]; other site 1093787002021 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1093787002022 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1093787002023 23S rRNA interface [nucleotide binding]; other site 1093787002024 L7/L12 interface [polypeptide binding]; other site 1093787002025 putative thiostrepton binding site; other site 1093787002026 L25 interface [polypeptide binding]; other site 1093787002027 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1093787002028 mRNA/rRNA interface [nucleotide binding]; other site 1093787002029 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1093787002030 23S rRNA interface [nucleotide binding]; other site 1093787002031 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1093787002032 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1093787002033 core dimer interface [polypeptide binding]; other site 1093787002034 peripheral dimer interface [polypeptide binding]; other site 1093787002035 L10 interface [polypeptide binding]; other site 1093787002036 L11 interface [polypeptide binding]; other site 1093787002037 putative EF-Tu interaction site [polypeptide binding]; other site 1093787002038 putative EF-G interaction site [polypeptide binding]; other site 1093787002039 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1093787002040 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1093787002041 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1093787002042 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1093787002043 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1093787002044 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1093787002045 RPB3 interaction site [polypeptide binding]; other site 1093787002046 RPB1 interaction site [polypeptide binding]; other site 1093787002047 RPB11 interaction site [polypeptide binding]; other site 1093787002048 RPB10 interaction site [polypeptide binding]; other site 1093787002049 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1093787002050 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1093787002051 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1093787002052 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1093787002053 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1093787002054 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1093787002055 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1093787002056 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1093787002057 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1093787002058 DNA binding site [nucleotide binding] 1093787002059 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1093787002060 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1093787002061 S17 interaction site [polypeptide binding]; other site 1093787002062 S8 interaction site; other site 1093787002063 16S rRNA interaction site [nucleotide binding]; other site 1093787002064 streptomycin interaction site [chemical binding]; other site 1093787002065 23S rRNA interaction site [nucleotide binding]; other site 1093787002066 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1093787002067 30S ribosomal protein S7; Validated; Region: PRK05302 1093787002068 elongation factor G; Reviewed; Region: PRK00007 1093787002069 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1093787002070 G1 box; other site 1093787002071 putative GEF interaction site [polypeptide binding]; other site 1093787002072 GTP/Mg2+ binding site [chemical binding]; other site 1093787002073 Switch I region; other site 1093787002074 G2 box; other site 1093787002075 G3 box; other site 1093787002076 Switch II region; other site 1093787002077 G4 box; other site 1093787002078 G5 box; other site 1093787002079 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1093787002080 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1093787002081 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1093787002082 elongation factor Tu; Reviewed; Region: PRK00049 1093787002083 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1093787002084 G1 box; other site 1093787002085 GEF interaction site [polypeptide binding]; other site 1093787002086 GTP/Mg2+ binding site [chemical binding]; other site 1093787002087 Switch I region; other site 1093787002088 G2 box; other site 1093787002089 G3 box; other site 1093787002090 Switch II region; other site 1093787002091 G4 box; other site 1093787002092 G5 box; other site 1093787002093 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1093787002094 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1093787002095 Antibiotic Binding Site [chemical binding]; other site 1093787002096 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1093787002097 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1093787002098 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1093787002099 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1093787002100 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1093787002101 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1093787002102 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1093787002103 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1093787002104 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1093787002105 protein-rRNA interface [nucleotide binding]; other site 1093787002106 putative translocon binding site; other site 1093787002107 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1093787002108 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1093787002109 G-X-X-G motif; other site 1093787002110 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1093787002111 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1093787002112 23S rRNA interface [nucleotide binding]; other site 1093787002113 5S rRNA interface [nucleotide binding]; other site 1093787002114 putative antibiotic binding site [chemical binding]; other site 1093787002115 L25 interface [polypeptide binding]; other site 1093787002116 L27 interface [polypeptide binding]; other site 1093787002117 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1093787002118 23S rRNA interface [nucleotide binding]; other site 1093787002119 putative translocon interaction site; other site 1093787002120 signal recognition particle (SRP54) interaction site; other site 1093787002121 L23 interface [polypeptide binding]; other site 1093787002122 trigger factor interaction site; other site 1093787002123 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1093787002124 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1093787002125 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1093787002126 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1093787002127 RNA binding site [nucleotide binding]; other site 1093787002128 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1093787002129 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1093787002130 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1093787002131 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1093787002132 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1093787002133 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1093787002134 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1093787002135 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1093787002136 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1093787002137 5S rRNA interface [nucleotide binding]; other site 1093787002138 23S rRNA interface [nucleotide binding]; other site 1093787002139 L5 interface [polypeptide binding]; other site 1093787002140 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1093787002141 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1093787002142 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1093787002143 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1093787002144 23S rRNA binding site [nucleotide binding]; other site 1093787002145 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1093787002146 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1093787002147 SecY translocase; Region: SecY; pfam00344 1093787002148 Ribosomal protein L36 [Translation, ribosomal structure and biogenesis]; Region: RpmJ; COG0257 1093787002149 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1093787002150 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1093787002151 30S ribosomal protein S11; Validated; Region: PRK05309 1093787002152 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1093787002153 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1093787002154 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1093787002155 RNA binding surface [nucleotide binding]; other site 1093787002156 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1093787002157 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1093787002158 alphaNTD homodimer interface [polypeptide binding]; other site 1093787002159 alphaNTD - beta interaction site [polypeptide binding]; other site 1093787002160 alphaNTD - beta' interaction site [polypeptide binding]; other site 1093787002161 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1093787002162 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1093787002163 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1093787002164 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1093787002165 tetramer interface [polypeptide binding]; other site 1093787002166 heme binding pocket [chemical binding]; other site 1093787002167 NADPH binding site [chemical binding]; other site 1093787002168 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1093787002169 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1093787002170 heme binding site [chemical binding]; other site 1093787002171 ferroxidase pore; other site 1093787002172 ferroxidase diiron center [ion binding]; other site 1093787002173 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1093787002174 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1093787002175 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1093787002176 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1093787002177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787002178 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1093787002179 putative substrate translocation pore; other site 1093787002180 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1093787002181 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1093787002182 ssDNA binding site [nucleotide binding]; other site 1093787002183 dimer interface [polypeptide binding]; other site 1093787002184 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1093787002185 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 1093787002186 isochorismate synthases; Region: isochor_syn; TIGR00543 1093787002187 isochorismate-pyruvate lyase; Reviewed; Region: PRK07075 1093787002188 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1093787002189 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1093787002190 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1093787002191 acyl-activating enzyme (AAE) consensus motif; other site 1093787002192 active site 1093787002193 AMP binding site [chemical binding]; other site 1093787002194 substrate binding site [chemical binding]; other site 1093787002195 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787002196 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787002197 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1093787002198 Condensation domain; Region: Condensation; pfam00668 1093787002199 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1093787002200 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1093787002201 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1093787002202 acyl-activating enzyme (AAE) consensus motif; other site 1093787002203 AMP binding site [chemical binding]; other site 1093787002204 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1093787002205 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1093787002206 Condensation domain; Region: Condensation; pfam00668 1093787002207 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1093787002208 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1093787002209 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1093787002210 acyl-activating enzyme (AAE) consensus motif; other site 1093787002211 AMP binding site [chemical binding]; other site 1093787002212 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1093787002213 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1093787002214 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1093787002215 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 1093787002216 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1093787002217 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1093787002218 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787002219 Walker A/P-loop; other site 1093787002220 ATP binding site [chemical binding]; other site 1093787002221 Q-loop/lid; other site 1093787002222 ABC transporter signature motif; other site 1093787002223 Walker B; other site 1093787002224 D-loop; other site 1093787002225 H-loop/switch region; other site 1093787002226 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1093787002227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787002228 Walker A/P-loop; other site 1093787002229 ATP binding site [chemical binding]; other site 1093787002230 Q-loop/lid; other site 1093787002231 ABC transporter signature motif; other site 1093787002232 Walker B; other site 1093787002233 D-loop; other site 1093787002234 H-loop/switch region; other site 1093787002235 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1093787002236 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787002237 N-terminal plug; other site 1093787002238 ligand-binding site [chemical binding]; other site 1093787002239 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1093787002240 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 1093787002241 Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000 1093787002242 hypothetical protein; Provisional; Region: PRK07538 1093787002243 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1093787002244 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 1093787002245 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1093787002246 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1093787002247 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 1093787002248 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1093787002249 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1093787002250 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1093787002251 glutamine binding [chemical binding]; other site 1093787002252 catalytic triad [active] 1093787002253 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1093787002254 hydrophobic substrate binding pocket; other site 1093787002255 Isochorismatase family; Region: Isochorismatase; pfam00857 1093787002256 active site 1093787002257 conserved cis-peptide bond; other site 1093787002258 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 1093787002259 Phenazine biosynthesis protein A/B; Region: PHZA_PHZB; pfam03284 1093787002260 Phenazine biosynthesis protein A/B; Region: PHZA_PHZB; pfam03284 1093787002261 O-methyltransferase; Region: Methyltransf_2; pfam00891 1093787002262 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1093787002263 multidrug efflux protein; Reviewed; Region: PRK09579 1093787002264 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1093787002265 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787002266 Predicted membrane protein [Function unknown]; Region: COG2259 1093787002267 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1093787002268 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787002269 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787002270 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1093787002271 putative dimerization interface [polypeptide binding]; other site 1093787002272 Nitronate monooxygenase; Region: NMO; pfam03060 1093787002273 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1093787002274 FMN binding site [chemical binding]; other site 1093787002275 substrate binding site [chemical binding]; other site 1093787002276 putative catalytic residue [active] 1093787002277 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1093787002278 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1093787002279 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1093787002280 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1093787002281 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1093787002282 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1093787002283 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787002284 active site 1093787002285 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1093787002286 acyl-CoA synthetase; Validated; Region: PRK08162 1093787002287 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1093787002288 acyl-activating enzyme (AAE) consensus motif; other site 1093787002289 putative active site [active] 1093787002290 AMP binding site [chemical binding]; other site 1093787002291 putative CoA binding site [chemical binding]; other site 1093787002292 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1093787002293 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787002294 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1093787002295 putative active site [active] 1093787002296 heme pocket [chemical binding]; other site 1093787002297 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1093787002298 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1093787002299 putative active site [active] 1093787002300 heme pocket [chemical binding]; other site 1093787002301 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787002302 dimer interface [polypeptide binding]; other site 1093787002303 phosphorylation site [posttranslational modification] 1093787002304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787002305 ATP binding site [chemical binding]; other site 1093787002306 Mg2+ binding site [ion binding]; other site 1093787002307 G-X-G motif; other site 1093787002308 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1093787002309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787002310 active site 1093787002311 phosphorylation site [posttranslational modification] 1093787002312 intermolecular recognition site; other site 1093787002313 dimerization interface [polypeptide binding]; other site 1093787002314 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787002315 DNA binding residues [nucleotide binding] 1093787002316 dimerization interface [polypeptide binding]; other site 1093787002317 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1093787002318 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787002319 substrate binding pocket [chemical binding]; other site 1093787002320 membrane-bound complex binding site; other site 1093787002321 hinge residues; other site 1093787002322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787002323 dimer interface [polypeptide binding]; other site 1093787002324 conserved gate region; other site 1093787002325 putative PBP binding loops; other site 1093787002326 ABC-ATPase subunit interface; other site 1093787002327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787002328 dimer interface [polypeptide binding]; other site 1093787002329 conserved gate region; other site 1093787002330 putative PBP binding loops; other site 1093787002331 ABC-ATPase subunit interface; other site 1093787002332 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1093787002333 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1093787002334 Walker A/P-loop; other site 1093787002335 ATP binding site [chemical binding]; other site 1093787002336 Q-loop/lid; other site 1093787002337 ABC transporter signature motif; other site 1093787002338 Walker B; other site 1093787002339 D-loop; other site 1093787002340 H-loop/switch region; other site 1093787002341 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1093787002342 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1093787002343 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1093787002344 putative monooxygenase; Reviewed; Region: PRK07045 1093787002345 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1093787002346 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1093787002347 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1093787002348 NAD(P) binding site [chemical binding]; other site 1093787002349 catalytic residues [active] 1093787002350 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1093787002351 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1093787002352 inhibitor site; inhibition site 1093787002353 active site 1093787002354 dimer interface [polypeptide binding]; other site 1093787002355 catalytic residue [active] 1093787002356 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 1093787002357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1093787002358 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1093787002359 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1093787002360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787002361 Coenzyme A binding pocket [chemical binding]; other site 1093787002362 putative arabinose transporter; Provisional; Region: PRK03545 1093787002363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787002364 putative substrate translocation pore; other site 1093787002365 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3614 1093787002366 PAS domain S-box; Region: sensory_box; TIGR00229 1093787002367 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787002368 putative active site [active] 1093787002369 heme pocket [chemical binding]; other site 1093787002370 PAS domain; Region: PAS_9; pfam13426 1093787002371 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787002372 putative active site [active] 1093787002373 heme pocket [chemical binding]; other site 1093787002374 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787002375 PAS fold; Region: PAS_3; pfam08447 1093787002376 putative active site [active] 1093787002377 heme pocket [chemical binding]; other site 1093787002378 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787002379 dimer interface [polypeptide binding]; other site 1093787002380 phosphorylation site [posttranslational modification] 1093787002381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787002382 ATP binding site [chemical binding]; other site 1093787002383 Mg2+ binding site [ion binding]; other site 1093787002384 G-X-G motif; other site 1093787002385 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1093787002386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787002387 active site 1093787002388 phosphorylation site [posttranslational modification] 1093787002389 intermolecular recognition site; other site 1093787002390 dimerization interface [polypeptide binding]; other site 1093787002391 Response regulator receiver domain; Region: Response_reg; pfam00072 1093787002392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787002393 active site 1093787002394 phosphorylation site [posttranslational modification] 1093787002395 intermolecular recognition site; other site 1093787002396 dimerization interface [polypeptide binding]; other site 1093787002397 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1093787002398 putative binding surface; other site 1093787002399 active site 1093787002400 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1093787002401 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 1093787002402 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1093787002403 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787002404 The C-terminal substrate-domain of LysR-type transcriptional regulators for beta-lactamase genes, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_beta_lactamase; cd08484 1093787002405 putative dimerization interface [polypeptide binding]; other site 1093787002406 putative substrate binding pocket [chemical binding]; other site 1093787002407 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 1093787002408 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1093787002409 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1093787002410 Zn2+ binding site [ion binding]; other site 1093787002411 Mg2+ binding site [ion binding]; other site 1093787002412 SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate...; Region: SPARC_EC; cd00252 1093787002413 EF-hand Ca2+ binding loops [ion binding]; other site 1093787002414 FS-domain interface [polypeptide binding]; other site 1093787002415 Protein of unknown function (DUF692); Region: DUF692; pfam05114 1093787002416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3219 1093787002417 DoxX; Region: DoxX; pfam07681 1093787002418 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 1093787002419 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1093787002420 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1093787002421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787002422 ATP binding site [chemical binding]; other site 1093787002423 Mg2+ binding site [ion binding]; other site 1093787002424 G-X-G motif; other site 1093787002425 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1093787002426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787002427 active site 1093787002428 phosphorylation site [posttranslational modification] 1093787002429 intermolecular recognition site; other site 1093787002430 dimerization interface [polypeptide binding]; other site 1093787002431 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787002432 DNA binding site [nucleotide binding] 1093787002433 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1093787002434 choline dehydrogenase; Validated; Region: PRK02106 1093787002435 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1093787002436 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 1093787002437 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1093787002438 classical (c) SDRs; Region: SDR_c; cd05233 1093787002439 NAD(P) binding site [chemical binding]; other site 1093787002440 active site 1093787002441 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1093787002442 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1093787002443 putative NAD(P) binding site [chemical binding]; other site 1093787002444 catalytic Zn binding site [ion binding]; other site 1093787002445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787002446 D-galactonate transporter; Region: 2A0114; TIGR00893 1093787002447 putative substrate translocation pore; other site 1093787002448 Cupin domain; Region: Cupin_2; pfam07883 1093787002449 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787002450 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787002451 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1093787002452 CoenzymeA binding site [chemical binding]; other site 1093787002453 subunit interaction site [polypeptide binding]; other site 1093787002454 PHB binding site; other site 1093787002455 Flavin Reductases; Region: FlaRed; cl00801 1093787002456 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 1093787002457 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1093787002458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3553 1093787002459 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1093787002460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787002461 NAD(P) binding site [chemical binding]; other site 1093787002462 active site 1093787002463 aminotransferase; Validated; Region: PRK07046 1093787002464 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1093787002465 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1093787002466 catalytic residue [active] 1093787002467 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 1093787002468 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1093787002469 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1093787002470 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1093787002471 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1093787002472 PapC N-terminal domain; Region: PapC_N; pfam13954 1093787002473 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1093787002474 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1093787002475 PapC C-terminal domain; Region: PapC_C; pfam13953 1093787002476 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1093787002477 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1093787002478 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1093787002479 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1093787002480 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1093787002481 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1093787002482 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1093787002483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787002484 active site 1093787002485 phosphorylation site [posttranslational modification] 1093787002486 intermolecular recognition site; other site 1093787002487 dimerization interface [polypeptide binding]; other site 1093787002488 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787002489 DNA binding residues [nucleotide binding] 1093787002490 dimerization interface [polypeptide binding]; other site 1093787002491 short chain dehydrogenase; Provisional; Region: PRK08177 1093787002492 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1093787002493 NAD(P) binding site [chemical binding]; other site 1093787002494 active site 1093787002495 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1093787002496 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1093787002497 acyl-activating enzyme (AAE) consensus motif; other site 1093787002498 AMP binding site [chemical binding]; other site 1093787002499 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1093787002500 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1093787002501 Male sterility protein; Region: NAD_binding_4; pfam07993 1093787002502 NAD(P) binding site [chemical binding]; other site 1093787002503 active site 1093787002504 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1093787002505 non-specific DNA binding site [nucleotide binding]; other site 1093787002506 salt bridge; other site 1093787002507 sequence-specific DNA binding site [nucleotide binding]; other site 1093787002508 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1093787002509 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787002510 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1093787002511 DNA binding residues [nucleotide binding] 1093787002512 dimerization interface [polypeptide binding]; other site 1093787002513 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1093787002514 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1093787002515 NAD(P) binding site [chemical binding]; other site 1093787002516 catalytic residues [active] 1093787002517 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1093787002518 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 1093787002519 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1093787002520 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787002521 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1093787002522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787002523 NAD(P) binding site [chemical binding]; other site 1093787002524 active site 1093787002525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787002526 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1093787002527 NAD(P) binding site [chemical binding]; other site 1093787002528 active site 1093787002529 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 1093787002530 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 1093787002531 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 1093787002532 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1093787002533 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1093787002534 FtsX-like permease family; Region: FtsX; pfam02687 1093787002535 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1093787002536 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1093787002537 Walker A/P-loop; other site 1093787002538 ATP binding site [chemical binding]; other site 1093787002539 Q-loop/lid; other site 1093787002540 ABC transporter signature motif; other site 1093787002541 Walker B; other site 1093787002542 D-loop; other site 1093787002543 H-loop/switch region; other site 1093787002544 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 1093787002545 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1093787002546 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1093787002547 Predicted methyltransferase [General function prediction only]; Region: COG3897 1093787002548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1093787002549 S-adenosylmethionine binding site [chemical binding]; other site 1093787002550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1093787002551 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1093787002552 ATP cone domain; Region: ATP-cone; pfam03477 1093787002553 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1093787002554 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1093787002555 catalytic motif [active] 1093787002556 Zn binding site [ion binding]; other site 1093787002557 RibD C-terminal domain; Region: RibD_C; cl17279 1093787002558 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1093787002559 Lumazine binding domain; Region: Lum_binding; pfam00677 1093787002560 Lumazine binding domain; Region: Lum_binding; pfam00677 1093787002561 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 1093787002562 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1093787002563 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1093787002564 dimerization interface [polypeptide binding]; other site 1093787002565 active site 1093787002566 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1093787002567 homopentamer interface [polypeptide binding]; other site 1093787002568 active site 1093787002569 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1093787002570 thiamine monophosphate kinase; Provisional; Region: PRK05731 1093787002571 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1093787002572 ATP binding site [chemical binding]; other site 1093787002573 dimerization interface [polypeptide binding]; other site 1093787002574 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1093787002575 tetramer interfaces [polypeptide binding]; other site 1093787002576 binuclear metal-binding site [ion binding]; other site 1093787002577 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1093787002578 Predicted aspartyl protease [General function prediction only]; Region: COG3577 1093787002579 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1093787002580 catalytic motif [active] 1093787002581 Catalytic residue [active] 1093787002582 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1093787002583 dimerization interface [polypeptide binding]; other site 1093787002584 active site 1093787002585 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1093787002586 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1093787002587 cobalamin binding residues [chemical binding]; other site 1093787002588 putative BtuC binding residues; other site 1093787002589 dimer interface [polypeptide binding]; other site 1093787002590 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1093787002591 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1093787002592 TPP-binding site; other site 1093787002593 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1093787002594 PYR/PP interface [polypeptide binding]; other site 1093787002595 dimer interface [polypeptide binding]; other site 1093787002596 TPP binding site [chemical binding]; other site 1093787002597 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1093787002598 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1093787002599 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1093787002600 substrate binding pocket [chemical binding]; other site 1093787002601 chain length determination region; other site 1093787002602 substrate-Mg2+ binding site; other site 1093787002603 catalytic residues [active] 1093787002604 aspartate-rich region 1; other site 1093787002605 active site lid residues [active] 1093787002606 aspartate-rich region 2; other site 1093787002607 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1093787002608 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1093787002609 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 1093787002610 putative active site pocket [active] 1093787002611 metal binding site [ion binding]; metal-binding site 1093787002612 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1093787002613 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1093787002614 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1093787002615 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1093787002616 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1093787002617 Walker A/P-loop; other site 1093787002618 ATP binding site [chemical binding]; other site 1093787002619 Q-loop/lid; other site 1093787002620 ABC transporter signature motif; other site 1093787002621 Walker B; other site 1093787002622 D-loop; other site 1093787002623 H-loop/switch region; other site 1093787002624 CHASE2 domain; Region: CHASE2; pfam05226 1093787002625 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1093787002626 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1093787002627 PAS domain; Region: PAS; smart00091 1093787002628 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787002629 dimer interface [polypeptide binding]; other site 1093787002630 phosphorylation site [posttranslational modification] 1093787002631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787002632 ATP binding site [chemical binding]; other site 1093787002633 Mg2+ binding site [ion binding]; other site 1093787002634 G-X-G motif; other site 1093787002635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 1093787002636 FecR protein; Region: FecR; pfam04773 1093787002637 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1093787002638 amphipathic channel; other site 1093787002639 Asn-Pro-Ala signature motifs; other site 1093787002640 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1093787002641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787002642 active site 1093787002643 phosphorylation site [posttranslational modification] 1093787002644 intermolecular recognition site; other site 1093787002645 dimerization interface [polypeptide binding]; other site 1093787002646 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787002647 DNA binding site [nucleotide binding] 1093787002648 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1093787002649 dimer interface [polypeptide binding]; other site 1093787002650 substrate binding site [chemical binding]; other site 1093787002651 metal binding sites [ion binding]; metal-binding site 1093787002652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3228 1093787002653 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1093787002654 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1093787002655 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1093787002656 substrate binding site [chemical binding]; other site 1093787002657 activation loop (A-loop); other site 1093787002658 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1093787002659 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787002660 substrate binding pocket [chemical binding]; other site 1093787002661 membrane-bound complex binding site; other site 1093787002662 hinge residues; other site 1093787002663 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787002664 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1093787002665 Coenzyme A binding pocket [chemical binding]; other site 1093787002666 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1093787002667 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1093787002668 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1093787002669 ethanolamine permease; Region: 2A0305; TIGR00908 1093787002670 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1093787002671 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1093787002672 NAD(P) binding site [chemical binding]; other site 1093787002673 catalytic residues [active] 1093787002674 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1093787002675 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787002676 putative active site [active] 1093787002677 heme pocket [chemical binding]; other site 1093787002678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787002679 Walker A motif; other site 1093787002680 ATP binding site [chemical binding]; other site 1093787002681 Walker B motif; other site 1093787002682 arginine finger; other site 1093787002683 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1093787002684 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1093787002685 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1093787002686 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1093787002687 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1093787002688 aromatic acid decarboxylase; Validated; Region: PRK05920 1093787002689 Flavoprotein; Region: Flavoprotein; pfam02441 1093787002690 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5645 1093787002691 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1093787002692 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1093787002693 NAD binding site [chemical binding]; other site 1093787002694 active site 1093787002695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1093787002696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1093787002697 MORN repeat; Region: MORN; cl14787 1093787002698 Peptidase C13 family; Region: Peptidase_C13; pfam01650 1093787002699 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1093787002700 putative active site [active] 1093787002701 putative catalytic site [active] 1093787002702 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1093787002703 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1093787002704 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1093787002705 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1093787002706 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1093787002707 active site 1093787002708 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1093787002709 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1093787002710 active site 1093787002711 DNA binding site [nucleotide binding] 1093787002712 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1093787002713 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1093787002714 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1093787002715 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1093787002716 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1093787002717 putative catalytic cysteine [active] 1093787002718 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1093787002719 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1093787002720 active site 1093787002721 (T/H)XGH motif; other site 1093787002722 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1093787002723 Uncharacterized conserved protein [Function unknown]; Region: COG1576 1093787002724 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1093787002725 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1093787002726 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1093787002727 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1093787002728 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1093787002729 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1093787002730 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1093787002731 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1093787002732 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1093787002733 Sporulation related domain; Region: SPOR; pfam05036 1093787002734 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1093787002735 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1093787002736 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1093787002737 hypothetical protein; Provisional; Region: PRK00341 1093787002738 lipoate-protein ligase B; Provisional; Region: PRK14342 1093787002739 lipoyl synthase; Provisional; Region: PRK05481 1093787002740 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1093787002741 FeS/SAM binding site; other site 1093787002742 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787002743 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787002744 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787002745 dimerization interface [polypeptide binding]; other site 1093787002746 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1093787002747 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1093787002748 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1093787002749 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1093787002750 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1093787002751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 1093787002752 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1093787002753 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1093787002754 Rare lipoprotein B [Cell envelope biogenesis, outer membrane]; Region: RlpB; COG2980 1093787002755 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1093787002756 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1093787002757 HIGH motif; other site 1093787002758 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1093787002759 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1093787002760 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1093787002761 active site 1093787002762 KMSKS motif; other site 1093787002763 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1093787002764 tRNA binding surface [nucleotide binding]; other site 1093787002765 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1093787002766 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1093787002767 putative active site [active] 1093787002768 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1093787002769 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1093787002770 putative active site [active] 1093787002771 catalytic triad [active] 1093787002772 putative dimer interface [polypeptide binding]; other site 1093787002773 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 1093787002774 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1093787002775 Transporter associated domain; Region: CorC_HlyC; smart01091 1093787002776 metal-binding heat shock protein; Provisional; Region: PRK00016 1093787002777 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1093787002778 PhoH-like protein; Region: PhoH; pfam02562 1093787002779 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1093787002780 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1093787002781 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1093787002782 FeS/SAM binding site; other site 1093787002783 TRAM domain; Region: TRAM; pfam01938 1093787002784 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4517 1093787002785 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1093787002786 Sel1-like repeats; Region: SEL1; smart00671 1093787002787 Sel1-like repeats; Region: SEL1; smart00671 1093787002788 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1093787002789 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1093787002790 inhibitor-cofactor binding pocket; inhibition site 1093787002791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787002792 catalytic residue [active] 1093787002793 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1093787002794 thiamine phosphate binding site [chemical binding]; other site 1093787002795 active site 1093787002796 pyrophosphate binding site [ion binding]; other site 1093787002797 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1093787002798 dimer interface [polypeptide binding]; other site 1093787002799 substrate binding site [chemical binding]; other site 1093787002800 ATP binding site [chemical binding]; other site 1093787002801 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1093787002802 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1093787002803 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1093787002804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787002805 dimer interface [polypeptide binding]; other site 1093787002806 phosphorylation site [posttranslational modification] 1093787002807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787002808 ATP binding site [chemical binding]; other site 1093787002809 Mg2+ binding site [ion binding]; other site 1093787002810 G-X-G motif; other site 1093787002811 Response regulator receiver domain; Region: Response_reg; pfam00072 1093787002812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787002813 active site 1093787002814 phosphorylation site [posttranslational modification] 1093787002815 intermolecular recognition site; other site 1093787002816 dimerization interface [polypeptide binding]; other site 1093787002817 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787002818 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787002819 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1093787002820 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787002821 active site 1093787002822 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1093787002823 CoenzymeA binding site [chemical binding]; other site 1093787002824 subunit interaction site [polypeptide binding]; other site 1093787002825 PHB binding site; other site 1093787002826 AMP nucleosidase; Provisional; Region: PRK08292 1093787002827 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1093787002828 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1093787002829 SEC-C motif; Region: SEC-C; pfam02810 1093787002830 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1093787002831 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1093787002832 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1093787002833 pseudouridine synthase; Region: TIGR00093 1093787002834 active site 1093787002835 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1093787002836 heme-binding site [chemical binding]; other site 1093787002837 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 1093787002838 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1093787002839 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1093787002840 putative DNA binding site [nucleotide binding]; other site 1093787002841 putative Zn2+ binding site [ion binding]; other site 1093787002842 AsnC family; Region: AsnC_trans_reg; pfam01037 1093787002843 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1093787002844 Cation efflux family; Region: Cation_efflux; cl00316 1093787002845 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1093787002846 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1093787002847 ATP binding site [chemical binding]; other site 1093787002848 putative Mg++ binding site [ion binding]; other site 1093787002849 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1093787002850 nucleotide binding region [chemical binding]; other site 1093787002851 ATP-binding site [chemical binding]; other site 1093787002852 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1093787002853 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1093787002854 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1093787002855 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1093787002856 putative metal binding site [ion binding]; other site 1093787002857 short chain dehydrogenase; Provisional; Region: PRK06181 1093787002858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787002859 NAD(P) binding site [chemical binding]; other site 1093787002860 active site 1093787002861 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1093787002862 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1093787002863 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 1093787002864 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1093787002865 active site 1093787002866 dimer interface [polypeptide binding]; other site 1093787002867 non-prolyl cis peptide bond; other site 1093787002868 insertion regions; other site 1093787002869 Isochorismatase family; Region: Isochorismatase; pfam00857 1093787002870 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1093787002871 catalytic triad [active] 1093787002872 conserved cis-peptide bond; other site 1093787002873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3416 1093787002874 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1093787002875 LabA_like proteins; Region: LabA; cd10911 1093787002876 putative metal binding site [ion binding]; other site 1093787002877 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1093787002878 ATP binding site [chemical binding]; other site 1093787002879 Mg++ binding site [ion binding]; other site 1093787002880 motif III; other site 1093787002881 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1093787002882 nucleotide binding region [chemical binding]; other site 1093787002883 ATP-binding site [chemical binding]; other site 1093787002884 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 1093787002885 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1093787002886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787002887 active site 1093787002888 phosphorylation site [posttranslational modification] 1093787002889 intermolecular recognition site; other site 1093787002890 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787002891 DNA binding residues [nucleotide binding] 1093787002892 dimerization interface [polypeptide binding]; other site 1093787002893 Response regulator receiver domain; Region: Response_reg; pfam00072 1093787002894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787002895 active site 1093787002896 phosphorylation site [posttranslational modification] 1093787002897 intermolecular recognition site; other site 1093787002898 dimerization interface [polypeptide binding]; other site 1093787002899 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1093787002900 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 1093787002901 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787002902 substrate binding pocket [chemical binding]; other site 1093787002903 membrane-bound complex binding site; other site 1093787002904 hinge residues; other site 1093787002905 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787002906 substrate binding pocket [chemical binding]; other site 1093787002907 membrane-bound complex binding site; other site 1093787002908 hinge residues; other site 1093787002909 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787002910 putative active site [active] 1093787002911 heme pocket [chemical binding]; other site 1093787002912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787002913 dimer interface [polypeptide binding]; other site 1093787002914 phosphorylation site [posttranslational modification] 1093787002915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787002916 ATP binding site [chemical binding]; other site 1093787002917 Mg2+ binding site [ion binding]; other site 1093787002918 G-X-G motif; other site 1093787002919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787002920 active site 1093787002921 phosphorylation site [posttranslational modification] 1093787002922 intermolecular recognition site; other site 1093787002923 dimerization interface [polypeptide binding]; other site 1093787002924 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1093787002925 putative binding surface; other site 1093787002926 active site 1093787002927 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1093787002928 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1093787002929 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1093787002930 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1093787002931 NADPH bind site [chemical binding]; other site 1093787002932 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1093787002933 putative FMN binding site [chemical binding]; other site 1093787002934 NADPH bind site [chemical binding]; other site 1093787002935 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1093787002936 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1093787002937 active site 1093787002938 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1093787002939 catalytic triad [active] 1093787002940 dimer interface [polypeptide binding]; other site 1093787002941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1093787002942 active site 1093787002943 motif I; other site 1093787002944 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1093787002945 motif II; other site 1093787002946 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1093787002947 IHF dimer interface [polypeptide binding]; other site 1093787002948 IHF - DNA interface [nucleotide binding]; other site 1093787002949 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787002950 active site 1093787002951 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1093787002952 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787002953 substrate binding pocket [chemical binding]; other site 1093787002954 membrane-bound complex binding site; other site 1093787002955 hinge residues; other site 1093787002956 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 1093787002957 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1093787002958 Walker A/P-loop; other site 1093787002959 ATP binding site [chemical binding]; other site 1093787002960 Q-loop/lid; other site 1093787002961 ABC transporter signature motif; other site 1093787002962 Walker B; other site 1093787002963 D-loop; other site 1093787002964 H-loop/switch region; other site 1093787002965 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1093787002966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787002967 dimer interface [polypeptide binding]; other site 1093787002968 conserved gate region; other site 1093787002969 putative PBP binding loops; other site 1093787002970 ABC-ATPase subunit interface; other site 1093787002971 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1093787002972 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 1093787002973 Predicted membrane protein [Function unknown]; Region: COG1297 1093787002974 BCCT family transporter; Region: BCCT; cl00569 1093787002975 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1093787002976 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787002977 Walker A motif; other site 1093787002978 ATP binding site [chemical binding]; other site 1093787002979 Walker B motif; other site 1093787002980 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1093787002981 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1093787002982 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1093787002983 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1093787002984 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1093787002985 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1093787002986 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1093787002987 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1093787002988 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787002989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787002990 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1093787002991 putative substrate translocation pore; other site 1093787002992 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1093787002993 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1093787002994 dimer interface [polypeptide binding]; other site 1093787002995 active site 1093787002996 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1093787002997 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1093787002998 dimer interface [polypeptide binding]; other site 1093787002999 acyl-activating enzyme (AAE) consensus motif; other site 1093787003000 putative active site [active] 1093787003001 AMP binding site [chemical binding]; other site 1093787003002 putative CoA binding site [chemical binding]; other site 1093787003003 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1093787003004 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1093787003005 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1093787003006 AAA ATPase domain; Region: AAA_16; pfam13191 1093787003007 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787003008 DNA binding residues [nucleotide binding] 1093787003009 dimerization interface [polypeptide binding]; other site 1093787003010 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1093787003011 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1093787003012 metal-binding site [ion binding] 1093787003013 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1093787003014 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1093787003015 metal-binding site [ion binding] 1093787003016 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1093787003017 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1093787003018 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1093787003019 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1093787003020 putative active site [active] 1093787003021 PhoH-like protein; Region: PhoH; pfam02562 1093787003022 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1093787003023 trimer interface [polypeptide binding]; other site 1093787003024 dimer interface [polypeptide binding]; other site 1093787003025 putative active site [active] 1093787003026 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1093787003027 MoaE interaction surface [polypeptide binding]; other site 1093787003028 MoeB interaction surface [polypeptide binding]; other site 1093787003029 thiocarboxylated glycine; other site 1093787003030 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1093787003031 MoaE homodimer interface [polypeptide binding]; other site 1093787003032 MoaD interaction [polypeptide binding]; other site 1093787003033 active site residues [active] 1093787003034 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1093787003035 MPT binding site; other site 1093787003036 trimer interface [polypeptide binding]; other site 1093787003037 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1093787003038 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1093787003039 dimer interface [polypeptide binding]; other site 1093787003040 putative functional site; other site 1093787003041 putative MPT binding site; other site 1093787003042 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1093787003043 Peptidase family U32; Region: Peptidase_U32; pfam01136 1093787003044 putative protease; Provisional; Region: PRK15447 1093787003045 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1093787003046 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1093787003047 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1093787003048 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1093787003049 putative active site [active] 1093787003050 putative metal binding site [ion binding]; other site 1093787003051 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1093787003052 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 1093787003053 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1093787003054 generic binding surface I; other site 1093787003055 generic binding surface II; other site 1093787003056 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 1093787003057 putative active site [active] 1093787003058 putative catalytic site [active] 1093787003059 putative Mg binding site IVb [ion binding]; other site 1093787003060 putative phosphate binding site [ion binding]; other site 1093787003061 putative DNA binding site [nucleotide binding]; other site 1093787003062 putative Mg binding site IVa [ion binding]; other site 1093787003063 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1093787003064 Uncharacterized conserved protein [Function unknown]; Region: COG4104 1093787003065 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1093787003066 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1093787003067 G1 box; other site 1093787003068 putative GEF interaction site [polypeptide binding]; other site 1093787003069 GTP/Mg2+ binding site [chemical binding]; other site 1093787003070 Switch I region; other site 1093787003071 G2 box; other site 1093787003072 G3 box; other site 1093787003073 Switch II region; other site 1093787003074 G4 box; other site 1093787003075 G5 box; other site 1093787003076 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1093787003077 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 1093787003078 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1093787003079 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787003080 N-terminal plug; other site 1093787003081 ligand-binding site [chemical binding]; other site 1093787003082 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1093787003083 FecR protein; Region: FecR; pfam04773 1093787003084 RNA polymerase sigma factor; Provisional; Region: PRK12528 1093787003085 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1093787003086 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1093787003087 DNA binding residues [nucleotide binding] 1093787003088 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1093787003089 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787003090 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1093787003091 EamA-like transporter family; Region: EamA; pfam00892 1093787003092 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1093787003093 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1093787003094 dimerization interface [polypeptide binding]; other site 1093787003095 ligand binding site [chemical binding]; other site 1093787003096 NADP binding site [chemical binding]; other site 1093787003097 catalytic site [active] 1093787003098 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787003099 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787003100 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1093787003101 putative effector binding pocket; other site 1093787003102 dimerization interface [polypeptide binding]; other site 1093787003103 Outer membrane efflux protein; Region: OEP; pfam02321 1093787003104 Outer membrane efflux protein; Region: OEP; pfam02321 1093787003105 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1093787003106 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1093787003107 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1093787003108 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1093787003109 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787003110 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787003111 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1093787003112 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1093787003113 Walker A/P-loop; other site 1093787003114 ATP binding site [chemical binding]; other site 1093787003115 Q-loop/lid; other site 1093787003116 ABC transporter signature motif; other site 1093787003117 Walker B; other site 1093787003118 D-loop; other site 1093787003119 H-loop/switch region; other site 1093787003120 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 1093787003121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787003122 dimer interface [polypeptide binding]; other site 1093787003123 conserved gate region; other site 1093787003124 ABC-ATPase subunit interface; other site 1093787003125 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1093787003126 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1093787003127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787003128 ABC-ATPase subunit interface; other site 1093787003129 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1093787003130 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1093787003131 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 1093787003132 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1093787003133 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1093787003134 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1093787003135 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1093787003136 active site 1093787003137 short chain dehydrogenase; Provisional; Region: PRK05693 1093787003138 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1093787003139 NADP binding site [chemical binding]; other site 1093787003140 active site 1093787003141 steroid binding site; other site 1093787003142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787003143 Uncharacterized conserved protein [Function unknown]; Region: COG4273 1093787003144 transcriptional regulator NarL; Provisional; Region: PRK10651 1093787003145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787003146 active site 1093787003147 phosphorylation site [posttranslational modification] 1093787003148 intermolecular recognition site; other site 1093787003149 dimerization interface [polypeptide binding]; other site 1093787003150 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787003151 DNA binding residues [nucleotide binding] 1093787003152 dimerization interface [polypeptide binding]; other site 1093787003153 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 1093787003154 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1093787003155 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787003156 dimerization interface [polypeptide binding]; other site 1093787003157 Histidine kinase; Region: HisKA_3; pfam07730 1093787003158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787003159 ATP binding site [chemical binding]; other site 1093787003160 Mg2+ binding site [ion binding]; other site 1093787003161 G-X-G motif; other site 1093787003162 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1093787003163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787003164 putative substrate translocation pore; other site 1093787003165 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1093787003166 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1093787003167 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1093787003168 [4Fe-4S] binding site [ion binding]; other site 1093787003169 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1093787003170 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1093787003171 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1093787003172 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1093787003173 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1093787003174 molybdopterin cofactor binding site; other site 1093787003175 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1093787003176 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1093787003177 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1093787003178 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1093787003179 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1093787003180 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 1093787003181 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1093787003182 FeS/SAM binding site; other site 1093787003183 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1093787003184 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1093787003185 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787003186 substrate binding pocket [chemical binding]; other site 1093787003187 membrane-bound complex binding site; other site 1093787003188 hinge residues; other site 1093787003189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1093787003190 YheO-like PAS domain; Region: PAS_6; pfam08348 1093787003191 HTH domain; Region: HTH_22; pfam13309 1093787003192 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1093787003193 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1093787003194 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1093787003195 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1093787003196 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1093787003197 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1093787003198 ATP binding site [chemical binding]; other site 1093787003199 Mg++ binding site [ion binding]; other site 1093787003200 motif III; other site 1093787003201 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1093787003202 nucleotide binding region [chemical binding]; other site 1093787003203 ATP-binding site [chemical binding]; other site 1093787003204 AMP-binding domain protein; Validated; Region: PRK07529 1093787003205 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1093787003206 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 1093787003207 acyl-activating enzyme (AAE) consensus motif; other site 1093787003208 putative AMP binding site [chemical binding]; other site 1093787003209 putative active site [active] 1093787003210 putative CoA binding site [chemical binding]; other site 1093787003211 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1093787003212 putative hydrolase; Provisional; Region: PRK11460 1093787003213 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1093787003214 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787003215 substrate binding pocket [chemical binding]; other site 1093787003216 membrane-bound complex binding site; other site 1093787003217 hinge residues; other site 1093787003218 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1093787003219 SnoaL-like domain; Region: SnoaL_3; pfam13474 1093787003220 SnoaL-like domain; Region: SnoaL_2; pfam12680 1093787003221 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 1093787003222 putative C-terminal domain interface [polypeptide binding]; other site 1093787003223 putative GSH binding site [chemical binding]; other site 1093787003224 putative dimer interface [polypeptide binding]; other site 1093787003225 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 1093787003226 putative N-terminal domain interface [polypeptide binding]; other site 1093787003227 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1093787003228 putative active site [active] 1093787003229 GIY-YIG motif/motif A; other site 1093787003230 putative metal binding site [ion binding]; other site 1093787003231 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1093787003232 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1093787003233 trimer interface [polypeptide binding]; other site 1093787003234 active site 1093787003235 substrate binding site [chemical binding]; other site 1093787003236 CoA binding site [chemical binding]; other site 1093787003237 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1093787003238 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1093787003239 C-terminal domain interface [polypeptide binding]; other site 1093787003240 GSH binding site (G-site) [chemical binding]; other site 1093787003241 dimer interface [polypeptide binding]; other site 1093787003242 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1093787003243 substrate binding pocket (H-site) [chemical binding]; other site 1093787003244 N-terminal domain interface [polypeptide binding]; other site 1093787003245 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 1093787003246 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1093787003247 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1093787003248 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1093787003249 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1093787003250 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1093787003251 hydrophobic ligand binding site; other site 1093787003252 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1093787003253 Isochorismatase family; Region: Isochorismatase; pfam00857 1093787003254 catalytic triad [active] 1093787003255 dimer interface [polypeptide binding]; other site 1093787003256 conserved cis-peptide bond; other site 1093787003257 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1093787003258 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787003259 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1093787003260 dimerization interface [polypeptide binding]; other site 1093787003261 substrate binding pocket [chemical binding]; other site 1093787003262 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1093787003263 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1093787003264 C-terminal domain interface [polypeptide binding]; other site 1093787003265 GSH binding site (G-site) [chemical binding]; other site 1093787003266 dimer interface [polypeptide binding]; other site 1093787003267 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1093787003268 dimer interface [polypeptide binding]; other site 1093787003269 N-terminal domain interface [polypeptide binding]; other site 1093787003270 putative substrate binding pocket (H-site) [chemical binding]; other site 1093787003271 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 1093787003272 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 1093787003273 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219 1093787003274 switch II binding region; other site 1093787003275 Rac1 P-loop interaction site [polypeptide binding]; other site 1093787003276 GTP binding residues [chemical binding]; other site 1093787003277 switch I binding region; other site 1093787003278 ADP-ribosyltransferase exoenzyme; Region: ADPrib_exo_Tox; pfam03496 1093787003279 active site 1093787003280 conformational flexibility of ligand binding pocket; other site 1093787003281 ADP-ribosylating toxin turn-turn motif; other site 1093787003282 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1093787003283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787003284 S-adenosylmethionine binding site [chemical binding]; other site 1093787003285 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1093787003286 transmembrane helices; other site 1093787003287 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1093787003288 TrkA-C domain; Region: TrkA_C; pfam02080 1093787003289 TrkA-C domain; Region: TrkA_C; pfam02080 1093787003290 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1093787003291 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1093787003292 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787003293 Walker A/P-loop; other site 1093787003294 ATP binding site [chemical binding]; other site 1093787003295 Q-loop/lid; other site 1093787003296 ABC transporter signature motif; other site 1093787003297 Walker B; other site 1093787003298 D-loop; other site 1093787003299 H-loop/switch region; other site 1093787003300 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1093787003301 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1093787003302 TM-ABC transporter signature motif; other site 1093787003303 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1093787003304 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1093787003305 zinc binding site [ion binding]; other site 1093787003306 putative ligand binding site [chemical binding]; other site 1093787003307 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1093787003308 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1093787003309 HIGH motif; other site 1093787003310 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1093787003311 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1093787003312 active site 1093787003313 KMSKS motif; other site 1093787003314 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1093787003315 tRNA binding surface [nucleotide binding]; other site 1093787003316 anticodon binding site; other site 1093787003317 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1093787003318 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 1093787003319 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1093787003320 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1093787003321 interface (dimer of trimers) [polypeptide binding]; other site 1093787003322 Substrate-binding/catalytic site; other site 1093787003323 Zn-binding sites [ion binding]; other site 1093787003324 Cupin domain; Region: Cupin_2; pfam07883 1093787003325 Helix-turn-helix domain; Region: HTH_18; pfam12833 1093787003326 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1093787003327 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1093787003328 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1093787003329 Predicted permeases [General function prediction only]; Region: COG0795 1093787003330 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1093787003331 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1093787003332 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1093787003333 RDD family; Region: RDD; pfam06271 1093787003334 phage resistance protein; Provisional; Region: PRK10551 1093787003335 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1093787003336 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1093787003337 Mu-like prophage protein Com; Region: Mu-like_Com; pfam10122 1093787003338 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1093787003339 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1093787003340 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1093787003341 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1093787003342 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1093787003343 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1093787003344 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1093787003345 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1093787003346 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1093787003347 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1093787003348 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1093787003349 Protein export membrane protein; Region: SecD_SecF; cl14618 1093787003350 hypothetical protein; Provisional; Region: PRK11280 1093787003351 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1093787003352 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1093787003353 active site 1093787003354 dimerization interface [polypeptide binding]; other site 1093787003355 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1093787003356 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1093787003357 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1093787003358 serine O-acetyltransferase; Region: cysE; TIGR01172 1093787003359 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1093787003360 trimer interface [polypeptide binding]; other site 1093787003361 active site 1093787003362 substrate binding site [chemical binding]; other site 1093787003363 CoA binding site [chemical binding]; other site 1093787003364 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 1093787003365 Rrf2 family protein; Region: rrf2_super; TIGR00738 1093787003366 cysteine desulfurase; Provisional; Region: PRK14012 1093787003367 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1093787003368 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1093787003369 catalytic residue [active] 1093787003370 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1093787003371 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1093787003372 trimerization site [polypeptide binding]; other site 1093787003373 active site 1093787003374 iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011 1093787003375 co-chaperone HscB; Provisional; Region: hscB; PRK00294 1093787003376 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1093787003377 HSP70 interaction site [polypeptide binding]; other site 1093787003378 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1093787003379 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1093787003380 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1093787003381 nucleotide binding site [chemical binding]; other site 1093787003382 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1093787003383 SBD interface [polypeptide binding]; other site 1093787003384 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1093787003385 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1093787003386 catalytic loop [active] 1093787003387 iron binding site [ion binding]; other site 1093787003388 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 1093787003389 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1093787003390 active site 1093787003391 multimer interface [polypeptide binding]; other site 1093787003392 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1093787003393 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1093787003394 FeS/SAM binding site; other site 1093787003395 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 1093787003396 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1093787003397 binding surface 1093787003398 TPR motif; other site 1093787003399 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1093787003400 binding surface 1093787003401 TPR motif; other site 1093787003402 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1093787003403 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1093787003404 non-specific DNA binding site [nucleotide binding]; other site 1093787003405 salt bridge; other site 1093787003406 sequence-specific DNA binding site [nucleotide binding]; other site 1093787003407 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1093787003408 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1093787003409 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1093787003410 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1093787003411 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1093787003412 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1093787003413 dimer interface [polypeptide binding]; other site 1093787003414 motif 1; other site 1093787003415 active site 1093787003416 motif 2; other site 1093787003417 motif 3; other site 1093787003418 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1093787003419 anticodon binding site; other site 1093787003420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1093787003421 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1093787003422 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 1093787003423 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1093787003424 Trp docking motif [polypeptide binding]; other site 1093787003425 active site 1093787003426 GTP-binding protein Der; Reviewed; Region: PRK00093 1093787003427 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1093787003428 G1 box; other site 1093787003429 GTP/Mg2+ binding site [chemical binding]; other site 1093787003430 Switch I region; other site 1093787003431 G2 box; other site 1093787003432 Switch II region; other site 1093787003433 G3 box; other site 1093787003434 G4 box; other site 1093787003435 G5 box; other site 1093787003436 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1093787003437 G1 box; other site 1093787003438 GTP/Mg2+ binding site [chemical binding]; other site 1093787003439 Switch I region; other site 1093787003440 G2 box; other site 1093787003441 G3 box; other site 1093787003442 Switch II region; other site 1093787003443 G4 box; other site 1093787003444 G5 box; other site 1093787003445 methionine aminotransferase; Validated; Region: PRK09082 1093787003446 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1093787003447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787003448 homodimer interface [polypeptide binding]; other site 1093787003449 catalytic residue [active] 1093787003450 C-N hydrolase family amidase; Provisional; Region: PRK10438 1093787003451 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1093787003452 putative active site [active] 1093787003453 catalytic triad [active] 1093787003454 dimer interface [polypeptide binding]; other site 1093787003455 multimer interface [polypeptide binding]; other site 1093787003456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753 1093787003457 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1093787003458 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1093787003459 active site 1093787003460 catalytic tetrad [active] 1093787003461 2-isopropylmalate synthase; Validated; Region: PRK03739 1093787003462 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1093787003463 active site 1093787003464 catalytic residues [active] 1093787003465 metal binding site [ion binding]; metal-binding site 1093787003466 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1093787003467 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1093787003468 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787003469 N-terminal plug; other site 1093787003470 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 1093787003471 ligand-binding site [chemical binding]; other site 1093787003472 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1093787003473 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1093787003474 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1093787003475 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1093787003476 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1093787003477 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1093787003478 Peptidase family M23; Region: Peptidase_M23; pfam01551 1093787003479 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1093787003480 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 1093787003481 AZL_007950 family protein; Region: AZL_007950_fam; TIGR04061 1093787003482 Isochorismatase family; Region: Isochorismatase; pfam00857 1093787003483 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1093787003484 catalytic triad [active] 1093787003485 conserved cis-peptide bond; other site 1093787003486 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1093787003487 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1093787003488 conserved cys residue [active] 1093787003489 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787003490 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1093787003491 DctM-like transporters; Region: DctM; pfam06808 1093787003492 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1093787003493 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 1093787003494 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1093787003495 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1093787003496 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787003497 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787003498 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787003499 dimerization interface [polypeptide binding]; other site 1093787003500 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1093787003501 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1093787003502 generic binding surface II; other site 1093787003503 generic binding surface I; other site 1093787003504 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1093787003505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787003506 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1093787003507 dimerization interface [polypeptide binding]; other site 1093787003508 substrate binding pocket [chemical binding]; other site 1093787003509 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 1093787003510 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1093787003511 active site 1093787003512 Zn binding site [ion binding]; other site 1093787003513 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1093787003514 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1093787003515 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787003516 DNA binding residues [nucleotide binding] 1093787003517 dimerization interface [polypeptide binding]; other site 1093787003518 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1093787003519 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1093787003520 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1093787003521 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1093787003522 active site 1093787003523 GMP synthase; Reviewed; Region: guaA; PRK00074 1093787003524 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1093787003525 AMP/PPi binding site [chemical binding]; other site 1093787003526 candidate oxyanion hole; other site 1093787003527 catalytic triad [active] 1093787003528 potential glutamine specificity residues [chemical binding]; other site 1093787003529 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1093787003530 ATP Binding subdomain [chemical binding]; other site 1093787003531 Dimerization subdomain; other site 1093787003532 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1093787003533 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1093787003534 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1093787003535 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1093787003536 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1093787003537 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1093787003538 nucleoside/Zn binding site; other site 1093787003539 dimer interface [polypeptide binding]; other site 1093787003540 catalytic motif [active] 1093787003541 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1093787003542 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1093787003543 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 1093787003544 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1093787003545 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787003546 substrate binding pocket [chemical binding]; other site 1093787003547 membrane-bound complex binding site; other site 1093787003548 hinge residues; other site 1093787003549 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1093787003550 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1093787003551 catalytic residue [active] 1093787003552 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1093787003553 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1093787003554 dimerization interface [polypeptide binding]; other site 1093787003555 ATP binding site [chemical binding]; other site 1093787003556 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1093787003557 dimerization interface [polypeptide binding]; other site 1093787003558 ATP binding site [chemical binding]; other site 1093787003559 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1093787003560 putative active site [active] 1093787003561 catalytic triad [active] 1093787003562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1093787003563 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1093787003564 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1093787003565 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 1093787003566 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1093787003567 active site turn [active] 1093787003568 phosphorylation site [posttranslational modification] 1093787003569 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1093787003570 HPr interaction site; other site 1093787003571 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1093787003572 active site 1093787003573 phosphorylation site [posttranslational modification] 1093787003574 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1093787003575 regulatory protein interface [polypeptide binding]; other site 1093787003576 active site 1093787003577 regulatory phosphorylation site [posttranslational modification]; other site 1093787003578 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1093787003579 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1093787003580 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1093787003581 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1093787003582 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1093787003583 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1093787003584 dimer interface [polypeptide binding]; other site 1093787003585 active site 1093787003586 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1093787003587 dimer interface [polypeptide binding]; other site 1093787003588 active site 1093787003589 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1093787003590 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1093787003591 active site 1093787003592 dimer interface [polypeptide binding]; other site 1093787003593 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1093787003594 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787003595 DNA-binding site [nucleotide binding]; DNA binding site 1093787003596 UTRA domain; Region: UTRA; pfam07702 1093787003597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1093787003598 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1093787003599 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 1093787003600 nudix motif; other site 1093787003601 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1093787003602 putative active site [active] 1093787003603 putative CoA binding site [chemical binding]; other site 1093787003604 nudix motif; other site 1093787003605 metal binding site [ion binding]; metal-binding site 1093787003606 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1093787003607 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1093787003608 trimer interface [polypeptide binding]; other site 1093787003609 putative metal binding site [ion binding]; other site 1093787003610 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1093787003611 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1093787003612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787003613 ATP-grasp domain; Region: ATP-grasp; pfam02222 1093787003614 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1093787003615 active site 1093787003616 catalytic triad [active] 1093787003617 oxyanion hole [active] 1093787003618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787003619 metabolite-proton symporter; Region: 2A0106; TIGR00883 1093787003620 putative substrate translocation pore; other site 1093787003621 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1093787003622 Domain of unknown function DUF21; Region: DUF21; pfam01595 1093787003623 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1093787003624 Transporter associated domain; Region: CorC_HlyC; smart01091 1093787003625 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1093787003626 signal recognition particle protein; Provisional; Region: PRK10867 1093787003627 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1093787003628 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1093787003629 P loop; other site 1093787003630 GTP binding site [chemical binding]; other site 1093787003631 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1093787003632 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1093787003633 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1093787003634 RimM N-terminal domain; Region: RimM; pfam01782 1093787003635 PRC-barrel domain; Region: PRC; pfam05239 1093787003636 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1093787003637 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1093787003638 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1093787003639 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 1093787003640 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1093787003641 TrkA-N domain; Region: TrkA_N; pfam02254 1093787003642 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1093787003643 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1093787003644 active site 1093787003645 Int/Topo IB signature motif; other site 1093787003646 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1093787003647 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1093787003648 dimerization domain [polypeptide binding]; other site 1093787003649 dimer interface [polypeptide binding]; other site 1093787003650 catalytic residues [active] 1093787003651 homoserine dehydrogenase; Provisional; Region: PRK06349 1093787003652 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1093787003653 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1093787003654 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1093787003655 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1093787003656 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1093787003657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787003658 catalytic residue [active] 1093787003659 Chlorophyllase enzyme; Region: Chlorophyllase2; pfam12740 1093787003660 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1093787003661 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1093787003662 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1093787003663 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1093787003664 nucleotide binding site [chemical binding]; other site 1093787003665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789 1093787003666 PspA/IM30 family; Region: PspA_IM30; pfam04012 1093787003667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1093787003668 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1093787003669 ATPase involved in DNA repair; Region: DUF3686; pfam12458 1093787003670 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 1093787003671 linker region; other site 1093787003672 AAA domain; Region: AAA_22; pfam13401 1093787003673 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787003674 Walker A motif; other site 1093787003675 ATP binding site [chemical binding]; other site 1093787003676 Walker B motif; other site 1093787003677 Catalytic domain of vertebrate phospholipase D6 and similar proteins; Region: PLDc_vPLD6_like; cd09171 1093787003678 PLD-like domain; Region: PLDc_2; pfam13091 1093787003679 putative active site [active] 1093787003680 catalytic site [active] 1093787003681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 1093787003682 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1093787003683 DHH family; Region: DHH; pfam01368 1093787003684 DHHA1 domain; Region: DHHA1; pfam02272 1093787003685 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1093787003686 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1093787003687 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1093787003688 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1093787003689 active site 1093787003690 Zn binding site [ion binding]; other site 1093787003691 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1093787003692 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1093787003693 active site 1093787003694 FMN binding site [chemical binding]; other site 1093787003695 substrate binding site [chemical binding]; other site 1093787003696 homotetramer interface [polypeptide binding]; other site 1093787003697 catalytic residue [active] 1093787003698 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787003699 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787003700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787003701 putative substrate translocation pore; other site 1093787003702 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1093787003703 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1093787003704 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1093787003705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787003706 active site 1093787003707 phosphorylation site [posttranslational modification] 1093787003708 intermolecular recognition site; other site 1093787003709 dimerization interface [polypeptide binding]; other site 1093787003710 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787003711 DNA binding residues [nucleotide binding] 1093787003712 dimerization interface [polypeptide binding]; other site 1093787003713 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1093787003714 Protein of unknown function (DUF533); Region: DUF533; pfam04391 1093787003715 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1093787003716 putative metal binding site [ion binding]; other site 1093787003717 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787003718 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787003719 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787003720 dimerization interface [polypeptide binding]; other site 1093787003721 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1093787003722 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1093787003723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787003724 putative substrate translocation pore; other site 1093787003725 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1093787003726 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1093787003727 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787003728 dimerization interface [polypeptide binding]; other site 1093787003729 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787003730 dimer interface [polypeptide binding]; other site 1093787003731 putative CheW interface [polypeptide binding]; other site 1093787003732 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1093787003733 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1093787003734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787003735 S-adenosylmethionine binding site [chemical binding]; other site 1093787003736 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1093787003737 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1093787003738 putative binding surface; other site 1093787003739 active site 1093787003740 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1093787003741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787003742 ATP binding site [chemical binding]; other site 1093787003743 Mg2+ binding site [ion binding]; other site 1093787003744 G-X-G motif; other site 1093787003745 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1093787003746 Response regulator receiver domain; Region: Response_reg; pfam00072 1093787003747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787003748 active site 1093787003749 phosphorylation site [posttranslational modification] 1093787003750 intermolecular recognition site; other site 1093787003751 dimerization interface [polypeptide binding]; other site 1093787003752 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 1093787003753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787003754 active site 1093787003755 phosphorylation site [posttranslational modification] 1093787003756 intermolecular recognition site; other site 1093787003757 CheB methylesterase; Region: CheB_methylest; pfam01339 1093787003758 Response regulator receiver domain; Region: Response_reg; pfam00072 1093787003759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787003760 active site 1093787003761 phosphorylation site [posttranslational modification] 1093787003762 intermolecular recognition site; other site 1093787003763 dimerization interface [polypeptide binding]; other site 1093787003764 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787003765 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787003766 metal binding site [ion binding]; metal-binding site 1093787003767 active site 1093787003768 I-site; other site 1093787003769 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1093787003770 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1093787003771 RF-1 domain; Region: RF-1; pfam00472 1093787003772 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1093787003773 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1093787003774 dimer interface [polypeptide binding]; other site 1093787003775 putative anticodon binding site; other site 1093787003776 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1093787003777 motif 1; other site 1093787003778 active site 1093787003779 motif 2; other site 1093787003780 motif 3; other site 1093787003781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1093787003782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3930 1093787003783 Uncharacterized conserved protein [Function unknown]; Region: COG2013 1093787003784 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1093787003785 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1093787003786 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1093787003787 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1093787003788 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1093787003789 putative ADP-ribose binding site [chemical binding]; other site 1093787003790 putative active site [active] 1093787003791 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1093787003792 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1093787003793 ligand binding site [chemical binding]; other site 1093787003794 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1093787003795 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1093787003796 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1093787003797 metal-binding site [ion binding] 1093787003798 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1093787003799 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1093787003800 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 1093787003801 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 1093787003802 DNA binding residues [nucleotide binding] 1093787003803 dimer interface [polypeptide binding]; other site 1093787003804 putative metal binding site [ion binding]; other site 1093787003805 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1093787003806 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1093787003807 adenylate kinase; Reviewed; Region: adk; PRK00279 1093787003808 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1093787003809 AMP-binding site [chemical binding]; other site 1093787003810 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1093787003811 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1093787003812 Glycoprotease family; Region: Peptidase_M22; pfam00814 1093787003813 Protein of unknown function DUF72; Region: DUF72; cl00777 1093787003814 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1093787003815 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1093787003816 tetramer interface [polypeptide binding]; other site 1093787003817 active site 1093787003818 Mg2+/Mn2+ binding site [ion binding]; other site 1093787003819 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1093787003820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787003821 S-adenosylmethionine binding site [chemical binding]; other site 1093787003822 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1093787003823 Cytochrome P450; Region: p450; cl12078 1093787003824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787003825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787003826 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1093787003827 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1093787003828 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787003829 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787003830 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1093787003831 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 1093787003832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1093787003833 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1093787003834 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1093787003835 putative acyl-acceptor binding pocket; other site 1093787003836 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 1093787003837 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1093787003838 Walker A/P-loop; other site 1093787003839 ATP binding site [chemical binding]; other site 1093787003840 Q-loop/lid; other site 1093787003841 ABC transporter signature motif; other site 1093787003842 Walker B; other site 1093787003843 D-loop; other site 1093787003844 H-loop/switch region; other site 1093787003845 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1093787003846 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1093787003847 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 1093787003848 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1093787003849 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 1093787003850 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1093787003851 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1093787003852 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1093787003853 catalytic residue [active] 1093787003854 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 1093787003855 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1093787003856 putative trimer interface [polypeptide binding]; other site 1093787003857 putative CoA binding site [chemical binding]; other site 1093787003858 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1093787003859 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1093787003860 ArsC family; Region: ArsC; pfam03960 1093787003861 putative catalytic residues [active] 1093787003862 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1093787003863 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1093787003864 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 1093787003865 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1093787003866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787003867 homodimer interface [polypeptide binding]; other site 1093787003868 catalytic residue [active] 1093787003869 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 1093787003870 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1093787003871 metal binding triad; other site 1093787003872 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1093787003873 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1093787003874 Zn2+ binding site [ion binding]; other site 1093787003875 Mg2+ binding site [ion binding]; other site 1093787003876 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1093787003877 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1093787003878 methionine aminopeptidase; Provisional; Region: PRK08671 1093787003879 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1093787003880 active site 1093787003881 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1093787003882 rRNA interaction site [nucleotide binding]; other site 1093787003883 S8 interaction site; other site 1093787003884 putative laminin-1 binding site; other site 1093787003885 elongation factor Ts; Provisional; Region: tsf; PRK09377 1093787003886 UBA/TS-N domain; Region: UBA; pfam00627 1093787003887 Elongation factor TS; Region: EF_TS; pfam00889 1093787003888 Elongation factor TS; Region: EF_TS; pfam00889 1093787003889 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1093787003890 putative nucleotide binding site [chemical binding]; other site 1093787003891 uridine monophosphate binding site [chemical binding]; other site 1093787003892 homohexameric interface [polypeptide binding]; other site 1093787003893 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1093787003894 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1093787003895 hinge region; other site 1093787003896 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1093787003897 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1093787003898 catalytic residue [active] 1093787003899 putative FPP diphosphate binding site; other site 1093787003900 putative FPP binding hydrophobic cleft; other site 1093787003901 dimer interface [polypeptide binding]; other site 1093787003902 putative IPP diphosphate binding site; other site 1093787003903 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1093787003904 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1093787003905 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1093787003906 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1093787003907 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1093787003908 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1093787003909 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1093787003910 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1093787003911 active site 1093787003912 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1093787003913 protein binding site [polypeptide binding]; other site 1093787003914 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1093787003915 protein binding site [polypeptide binding]; other site 1093787003916 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1093787003917 putative substrate binding region [chemical binding]; other site 1093787003918 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1093787003919 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1093787003920 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1093787003921 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1093787003922 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1093787003923 Surface antigen; Region: Bac_surface_Ag; pfam01103 1093787003924 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 1093787003925 periplasmic chaperone; Provisional; Region: PRK10780 1093787003926 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1093787003927 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1093787003928 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1093787003929 trimer interface [polypeptide binding]; other site 1093787003930 active site 1093787003931 UDP-GlcNAc binding site [chemical binding]; other site 1093787003932 lipid binding site [chemical binding]; lipid-binding site 1093787003933 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1093787003934 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1093787003935 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1093787003936 active site 1093787003937 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1093787003938 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1093787003939 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1093787003940 RNA/DNA hybrid binding site [nucleotide binding]; other site 1093787003941 active site 1093787003942 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1093787003943 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1093787003944 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1093787003945 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1093787003946 putative active site [active] 1093787003947 putative PHP Thumb interface [polypeptide binding]; other site 1093787003948 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1093787003949 generic binding surface II; other site 1093787003950 generic binding surface I; other site 1093787003951 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1093787003952 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1093787003953 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1093787003954 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1093787003955 Ligand Binding Site [chemical binding]; other site 1093787003956 TilS substrate binding domain; Region: TilS; pfam09179 1093787003957 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1093787003958 CTP synthetase; Validated; Region: pyrG; PRK05380 1093787003959 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1093787003960 Catalytic site [active] 1093787003961 active site 1093787003962 UTP binding site [chemical binding]; other site 1093787003963 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1093787003964 active site 1093787003965 putative oxyanion hole; other site 1093787003966 catalytic triad [active] 1093787003967 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1093787003968 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1093787003969 enolase; Provisional; Region: eno; PRK00077 1093787003970 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1093787003971 dimer interface [polypeptide binding]; other site 1093787003972 metal binding site [ion binding]; metal-binding site 1093787003973 substrate binding pocket [chemical binding]; other site 1093787003974 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1093787003975 Septum formation initiator; Region: DivIC; cl17659 1093787003976 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1093787003977 substrate binding site; other site 1093787003978 dimer interface; other site 1093787003979 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 1093787003980 CPxP motif; other site 1093787003981 putative inner membrane protein; Provisional; Region: PRK11099 1093787003982 Sulphur transport; Region: Sulf_transp; pfam04143 1093787003983 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787003984 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787003985 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470 1093787003986 putative effector binding pocket; other site 1093787003987 putative dimerization interface [polypeptide binding]; other site 1093787003988 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1093787003989 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1093787003990 substrate binding site [chemical binding]; other site 1093787003991 catalytic Zn binding site [ion binding]; other site 1093787003992 NAD binding site [chemical binding]; other site 1093787003993 structural Zn binding site [ion binding]; other site 1093787003994 dimer interface [polypeptide binding]; other site 1093787003995 S-formylglutathione hydrolase; Region: PLN02442 1093787003996 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1093787003997 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1093787003998 homotrimer interaction site [polypeptide binding]; other site 1093787003999 zinc binding site [ion binding]; other site 1093787004000 CDP-binding sites; other site 1093787004001 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1093787004002 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1093787004003 Permutation of conserved domain; other site 1093787004004 active site 1093787004005 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1093787004006 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1093787004007 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1093787004008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787004009 S-adenosylmethionine binding site [chemical binding]; other site 1093787004010 Peptidase family M23; Region: Peptidase_M23; pfam01551 1093787004011 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1093787004012 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1093787004013 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1093787004014 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1093787004015 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1093787004016 DNA binding residues [nucleotide binding] 1093787004017 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1093787004018 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1093787004019 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1093787004020 MutS domain I; Region: MutS_I; pfam01624 1093787004021 MutS domain II; Region: MutS_II; pfam05188 1093787004022 MutS domain III; Region: MutS_III; pfam05192 1093787004023 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1093787004024 Walker A/P-loop; other site 1093787004025 ATP binding site [chemical binding]; other site 1093787004026 Q-loop/lid; other site 1093787004027 ABC transporter signature motif; other site 1093787004028 Walker B; other site 1093787004029 D-loop; other site 1093787004030 H-loop/switch region; other site 1093787004031 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1093787004032 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1093787004033 recombinase A; Provisional; Region: recA; PRK09354 1093787004034 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1093787004035 hexamer interface [polypeptide binding]; other site 1093787004036 Walker A motif; other site 1093787004037 ATP binding site [chemical binding]; other site 1093787004038 Walker B motif; other site 1093787004039 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1093787004040 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1093787004041 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1093787004042 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1093787004043 Beta-Casp domain; Region: Beta-Casp; smart01027 1093787004044 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1093787004045 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 1093787004046 XFP N-terminal domain; Region: XFP_N; pfam09364 1093787004047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 1093787004048 Domain of unknown function (DUF4146); Region: DUF4146; pfam13652 1093787004049 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1093787004050 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1093787004051 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1093787004052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787004053 dimer interface [polypeptide binding]; other site 1093787004054 conserved gate region; other site 1093787004055 putative PBP binding loops; other site 1093787004056 ABC-ATPase subunit interface; other site 1093787004057 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1093787004058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787004059 dimer interface [polypeptide binding]; other site 1093787004060 conserved gate region; other site 1093787004061 putative PBP binding loops; other site 1093787004062 ABC-ATPase subunit interface; other site 1093787004063 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1093787004064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787004065 Walker A/P-loop; other site 1093787004066 ATP binding site [chemical binding]; other site 1093787004067 Q-loop/lid; other site 1093787004068 ABC transporter signature motif; other site 1093787004069 Walker B; other site 1093787004070 D-loop; other site 1093787004071 H-loop/switch region; other site 1093787004072 TOBE domain; Region: TOBE_2; pfam08402 1093787004073 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1093787004074 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1093787004075 EamA-like transporter family; Region: EamA; pfam00892 1093787004076 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1093787004077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787004078 active site 1093787004079 phosphorylation site [posttranslational modification] 1093787004080 intermolecular recognition site; other site 1093787004081 dimerization interface [polypeptide binding]; other site 1093787004082 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787004083 DNA binding residues [nucleotide binding] 1093787004084 dimerization interface [polypeptide binding]; other site 1093787004085 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1093787004086 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1093787004087 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1093787004088 active site 1093787004089 FMN binding site [chemical binding]; other site 1093787004090 substrate binding site [chemical binding]; other site 1093787004091 3Fe-4S cluster binding site [ion binding]; other site 1093787004092 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1093787004093 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1093787004094 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1093787004095 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787004096 DNA binding residues [nucleotide binding] 1093787004097 dimerization interface [polypeptide binding]; other site 1093787004098 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1093787004099 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 1093787004100 putative active site [active] 1093787004101 catalytic triad [active] 1093787004102 putative dimer interface [polypeptide binding]; other site 1093787004103 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1093787004104 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1093787004105 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1093787004106 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1093787004107 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1093787004108 DNA binding site [nucleotide binding] 1093787004109 active site 1093787004110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787004111 metabolite-proton symporter; Region: 2A0106; TIGR00883 1093787004112 putative substrate translocation pore; other site 1093787004113 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787004114 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787004115 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 1093787004116 putative dimerization interface [polypeptide binding]; other site 1093787004117 putative substrate binding pocket [chemical binding]; other site 1093787004118 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787004119 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1093787004120 active site 1093787004121 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1093787004122 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1093787004123 enoyl-CoA hydratase; Provisional; Region: PRK08138 1093787004124 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1093787004125 substrate binding site [chemical binding]; other site 1093787004126 oxyanion hole (OAH) forming residues; other site 1093787004127 trimer interface [polypeptide binding]; other site 1093787004128 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 1093787004129 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1093787004130 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1093787004131 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1093787004132 acetyl-CoA acetyltransferase; Provisional; Region: PRK08131 1093787004133 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1093787004134 dimer interface [polypeptide binding]; other site 1093787004135 active site 1093787004136 outer membrane porin, OprD family; Region: OprD; pfam03573 1093787004137 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1093787004138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787004139 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1093787004140 putative dimerization interface [polypeptide binding]; other site 1093787004141 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1093787004142 GlpM protein; Region: GlpM; pfam06942 1093787004143 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1093787004144 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1093787004145 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1093787004146 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1093787004147 glycerol kinase; Provisional; Region: glpK; PRK00047 1093787004148 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1093787004149 N- and C-terminal domain interface [polypeptide binding]; other site 1093787004150 active site 1093787004151 MgATP binding site [chemical binding]; other site 1093787004152 catalytic site [active] 1093787004153 metal binding site [ion binding]; metal-binding site 1093787004154 glycerol binding site [chemical binding]; other site 1093787004155 homotetramer interface [polypeptide binding]; other site 1093787004156 homodimer interface [polypeptide binding]; other site 1093787004157 FBP binding site [chemical binding]; other site 1093787004158 protein IIAGlc interface [polypeptide binding]; other site 1093787004159 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1093787004160 amphipathic channel; other site 1093787004161 Asn-Pro-Ala signature motifs; other site 1093787004162 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1093787004163 putative deacylase active site [active] 1093787004164 glycerol kinase; Region: glycerol_kin; TIGR01311 1093787004165 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1093787004166 N- and C-terminal domain interface [polypeptide binding]; other site 1093787004167 active site 1093787004168 MgATP binding site [chemical binding]; other site 1093787004169 catalytic site [active] 1093787004170 metal binding site [ion binding]; metal-binding site 1093787004171 glycerol binding site [chemical binding]; other site 1093787004172 homotetramer interface [polypeptide binding]; other site 1093787004173 homodimer interface [polypeptide binding]; other site 1093787004174 FBP binding site [chemical binding]; other site 1093787004175 protein IIAGlc interface [polypeptide binding]; other site 1093787004176 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1093787004177 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1093787004178 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1093787004179 metal-binding site [ion binding] 1093787004180 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1093787004181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787004182 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1093787004183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787004184 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1093787004185 putative substrate translocation pore; other site 1093787004186 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1093787004187 Helix-turn-helix domain; Region: HTH_18; pfam12833 1093787004188 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787004189 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1093787004190 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1093787004191 tetrameric interface [polypeptide binding]; other site 1093787004192 NAD binding site [chemical binding]; other site 1093787004193 catalytic residues [active] 1093787004194 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1093787004195 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1093787004196 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1093787004197 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 1093787004198 acyl-activating enzyme (AAE) consensus motif; other site 1093787004199 putative AMP binding site [chemical binding]; other site 1093787004200 putative active site [active] 1093787004201 putative CoA binding site [chemical binding]; other site 1093787004202 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1093787004203 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1093787004204 putative NAD(P) binding site [chemical binding]; other site 1093787004205 dimer interface [polypeptide binding]; other site 1093787004206 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1093787004207 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787004208 transcriptional activator TtdR; Provisional; Region: PRK09801 1093787004209 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1093787004210 putative effector binding pocket; other site 1093787004211 dimerization interface [polypeptide binding]; other site 1093787004212 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 1093787004213 S-type Pyocin; Region: Pyocin_S; pfam06958 1093787004214 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1093787004215 active site 1093787004216 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1093787004217 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1093787004218 active site 1093787004219 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1093787004220 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1093787004221 DNA binding site [nucleotide binding] 1093787004222 domain linker motif; other site 1093787004223 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1093787004224 dimerization interface [polypeptide binding]; other site 1093787004225 ligand binding site [chemical binding]; other site 1093787004226 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1093787004227 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1093787004228 active site 1093787004229 phosphorylation site [posttranslational modification] 1093787004230 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 1093787004231 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1093787004232 dimerization domain swap beta strand [polypeptide binding]; other site 1093787004233 regulatory protein interface [polypeptide binding]; other site 1093787004234 active site 1093787004235 regulatory phosphorylation site [posttranslational modification]; other site 1093787004236 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1093787004237 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1093787004238 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1093787004239 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1093787004240 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1093787004241 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1093787004242 putative substrate binding site [chemical binding]; other site 1093787004243 putative ATP binding site [chemical binding]; other site 1093787004244 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1093787004245 active site 1093787004246 P-loop; other site 1093787004247 phosphorylation site [posttranslational modification] 1093787004248 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1093787004249 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1093787004250 active site 1093787004251 P-loop; other site 1093787004252 phosphorylation site [posttranslational modification] 1093787004253 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1093787004254 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1093787004255 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1093787004256 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1093787004257 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1093787004258 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1093787004259 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1093787004260 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1093787004261 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1093787004262 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1093787004263 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1093787004264 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1093787004265 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1093787004266 active site 1093787004267 substrate binding site [chemical binding]; other site 1093787004268 cosubstrate binding site; other site 1093787004269 catalytic site [active] 1093787004270 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1093787004271 active site 1093787004272 hexamer interface [polypeptide binding]; other site 1093787004273 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1093787004274 NAD binding site [chemical binding]; other site 1093787004275 substrate binding site [chemical binding]; other site 1093787004276 active site 1093787004277 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1093787004278 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1093787004279 Ligand binding site; other site 1093787004280 Putative Catalytic site; other site 1093787004281 DXD motif; other site 1093787004282 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1093787004283 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1093787004284 inhibitor-cofactor binding pocket; inhibition site 1093787004285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787004286 catalytic residue [active] 1093787004287 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1093787004288 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1093787004289 Substrate binding site; other site 1093787004290 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1093787004291 Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182 1093787004292 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1093787004293 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cd00244 1093787004294 active site 1093787004295 Right handed beta helix region; Region: Beta_helix; pfam13229 1093787004296 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1093787004297 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1093787004298 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1093787004299 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1093787004300 PilZ domain; Region: PilZ; pfam07238 1093787004301 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787004302 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1093787004303 active site 1093787004304 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1093787004305 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1093787004306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787004307 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1093787004308 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1093787004309 hypothetical protein; Validated; Region: PRK02101 1093787004310 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1093787004311 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1093787004312 Walker A/P-loop; other site 1093787004313 ATP binding site [chemical binding]; other site 1093787004314 Q-loop/lid; other site 1093787004315 ABC transporter signature motif; other site 1093787004316 Walker B; other site 1093787004317 D-loop; other site 1093787004318 H-loop/switch region; other site 1093787004319 TOBE domain; Region: TOBE_2; pfam08402 1093787004320 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1093787004321 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1093787004322 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1093787004323 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1093787004324 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 1093787004325 catalytic triad [active] 1093787004326 putative active site [active] 1093787004327 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1093787004328 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1093787004329 Autotransporter beta-domain; Region: Autotransporter; smart00869 1093787004330 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1093787004331 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1093787004332 putative [Fe4-S4] binding site [ion binding]; other site 1093787004333 putative molybdopterin cofactor binding site [chemical binding]; other site 1093787004334 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1093787004335 putative molybdopterin cofactor binding site; other site 1093787004336 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1093787004337 putative GSH binding site [chemical binding]; other site 1093787004338 catalytic residues [active] 1093787004339 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1093787004340 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1093787004341 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1093787004342 heme binding site [chemical binding]; other site 1093787004343 ferroxidase pore; other site 1093787004344 ferroxidase diiron center [ion binding]; other site 1093787004345 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1093787004346 peroxidase; Provisional; Region: PRK15000 1093787004347 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1093787004348 dimer interface [polypeptide binding]; other site 1093787004349 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1093787004350 catalytic triad [active] 1093787004351 peroxidatic and resolving cysteines [active] 1093787004352 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1093787004353 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1093787004354 dimer interface [polypeptide binding]; other site 1093787004355 catalytic site [active] 1093787004356 putative active site [active] 1093787004357 putative substrate binding site [chemical binding]; other site 1093787004358 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1093787004359 active site 1093787004360 substrate binding pocket [chemical binding]; other site 1093787004361 dimer interface [polypeptide binding]; other site 1093787004362 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1093787004363 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1093787004364 ligand binding site [chemical binding]; other site 1093787004365 argininosuccinate synthase; Provisional; Region: PRK13820 1093787004366 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1093787004367 ANP binding site [chemical binding]; other site 1093787004368 Substrate Binding Site II [chemical binding]; other site 1093787004369 Substrate Binding Site I [chemical binding]; other site 1093787004370 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1093787004371 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1093787004372 dimer interface [polypeptide binding]; other site 1093787004373 active site 1093787004374 metal binding site [ion binding]; metal-binding site 1093787004375 glutathione binding site [chemical binding]; other site 1093787004376 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1093787004377 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787004378 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787004379 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1093787004380 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1093787004381 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1093787004382 metal-binding site [ion binding] 1093787004383 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1093787004384 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1093787004385 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1093787004386 tetramer interface [polypeptide binding]; other site 1093787004387 active site 1093787004388 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1093787004389 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1093787004390 tetramer interface [polypeptide binding]; other site 1093787004391 active site 1093787004392 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1093787004393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787004394 S-adenosylmethionine binding site [chemical binding]; other site 1093787004395 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1093787004396 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1093787004397 minor groove reading motif; other site 1093787004398 helix-hairpin-helix signature motif; other site 1093787004399 substrate binding pocket [chemical binding]; other site 1093787004400 active site 1093787004401 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1093787004402 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1093787004403 Predicted NADH:ubiquinone oxidoreductase, subunit RnfG [Energy production and conversion]; Region: RnfG; COG4659 1093787004404 electron transport complex, RnfABCDGE type, D subunit; Region: rnfD; TIGR01946 1093787004405 electron transport complex protein RnfC; Provisional; Region: PRK05035 1093787004406 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1093787004407 SLBB domain; Region: SLBB; pfam10531 1093787004408 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1093787004409 electron transport complex protein RnfB; Provisional; Region: PRK05113 1093787004410 Putative Fe-S cluster; Region: FeS; pfam04060 1093787004411 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1093787004412 electron transport complex protein RsxA; Provisional; Region: PRK05151 1093787004413 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 1093787004414 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1093787004415 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1093787004416 active site 1093787004417 HIGH motif; other site 1093787004418 KMSKS motif; other site 1093787004419 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1093787004420 tRNA binding surface [nucleotide binding]; other site 1093787004421 anticodon binding site; other site 1093787004422 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1093787004423 putative tRNA-binding site [nucleotide binding]; other site 1093787004424 dimer interface [polypeptide binding]; other site 1093787004425 antiporter inner membrane protein; Provisional; Region: PRK11670 1093787004426 Domain of unknown function DUF59; Region: DUF59; pfam01883 1093787004427 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1093787004428 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1093787004429 trimer interface [polypeptide binding]; other site 1093787004430 active site 1093787004431 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1093787004432 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1093787004433 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1093787004434 homodimer interface [polypeptide binding]; other site 1093787004435 active site 1093787004436 TDP-binding site; other site 1093787004437 acceptor substrate-binding pocket; other site 1093787004438 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1093787004439 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1093787004440 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787004441 DNA binding residues [nucleotide binding] 1093787004442 dimerization interface [polypeptide binding]; other site 1093787004443 N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916 1093787004444 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1093787004445 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787004446 substrate binding pocket [chemical binding]; other site 1093787004447 membrane-bound complex binding site; other site 1093787004448 hinge residues; other site 1093787004449 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1093787004450 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1093787004451 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1093787004452 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1093787004453 NlpC/P60 family; Region: NLPC_P60; pfam00877 1093787004454 malate dehydrogenase; Provisional; Region: PRK13529 1093787004455 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1093787004456 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1093787004457 NAD(P) binding site [chemical binding]; other site 1093787004458 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1093787004459 nudix motif; other site 1093787004460 RibD C-terminal domain; Region: RibD_C; cl17279 1093787004461 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1093787004462 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1093787004463 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1093787004464 benzoate transport; Region: 2A0115; TIGR00895 1093787004465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787004466 putative substrate translocation pore; other site 1093787004467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787004468 helicase 45; Provisional; Region: PTZ00424 1093787004469 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1093787004470 ATP binding site [chemical binding]; other site 1093787004471 Mg++ binding site [ion binding]; other site 1093787004472 motif III; other site 1093787004473 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1093787004474 nucleotide binding region [chemical binding]; other site 1093787004475 ATP-binding site [chemical binding]; other site 1093787004476 Transmembrane secretion effector; Region: MFS_3; pfam05977 1093787004477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787004478 putative substrate translocation pore; other site 1093787004479 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 1093787004480 Uncharacterized protein family (UPF0270); Region: UPF0270; cl01180 1093787004481 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1093787004482 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1093787004483 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1093787004484 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787004485 dimer interface [polypeptide binding]; other site 1093787004486 phosphorylation site [posttranslational modification] 1093787004487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787004488 ATP binding site [chemical binding]; other site 1093787004489 Mg2+ binding site [ion binding]; other site 1093787004490 G-X-G motif; other site 1093787004491 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1093787004492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787004493 active site 1093787004494 phosphorylation site [posttranslational modification] 1093787004495 intermolecular recognition site; other site 1093787004496 dimerization interface [polypeptide binding]; other site 1093787004497 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1093787004498 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1093787004499 putative oligomer interface [polypeptide binding]; other site 1093787004500 putative active site [active] 1093787004501 metal binding site [ion binding]; metal-binding site 1093787004502 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 1093787004503 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1093787004504 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1093787004505 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 1093787004506 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1093787004507 active site 1093787004508 dimer interface [polypeptide binding]; other site 1093787004509 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1093787004510 Ligand Binding Site [chemical binding]; other site 1093787004511 Molecular Tunnel; other site 1093787004512 MarR family; Region: MarR_2; cl17246 1093787004513 Predicted permeases [General function prediction only]; Region: COG0730 1093787004514 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1093787004515 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1093787004516 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 1093787004517 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1093787004518 Uncharacterized conserved protein [Function unknown]; Region: COG2326 1093787004519 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 1093787004520 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1093787004521 dimer interface [polypeptide binding]; other site 1093787004522 active site 1093787004523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1093787004524 malate:quinone oxidoreductase; Validated; Region: PRK05257 1093787004525 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1093787004526 Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607 1093787004527 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1093787004528 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1093787004529 dimer interface [polypeptide binding]; other site 1093787004530 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1093787004531 catalytic triad [active] 1093787004532 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1093787004533 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787004534 substrate binding pocket [chemical binding]; other site 1093787004535 membrane-bound complex binding site; other site 1093787004536 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1093787004537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787004538 dimer interface [polypeptide binding]; other site 1093787004539 conserved gate region; other site 1093787004540 putative PBP binding loops; other site 1093787004541 ABC-ATPase subunit interface; other site 1093787004542 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1093787004543 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1093787004544 Walker A/P-loop; other site 1093787004545 ATP binding site [chemical binding]; other site 1093787004546 Q-loop/lid; other site 1093787004547 ABC transporter signature motif; other site 1093787004548 Walker B; other site 1093787004549 D-loop; other site 1093787004550 H-loop/switch region; other site 1093787004551 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 1093787004552 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1093787004553 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1093787004554 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787004555 substrate binding pocket [chemical binding]; other site 1093787004556 membrane-bound complex binding site; other site 1093787004557 hinge residues; other site 1093787004558 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1093787004559 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1093787004560 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1093787004561 active site 1093787004562 dimer interface [polypeptide binding]; other site 1093787004563 non-prolyl cis peptide bond; other site 1093787004564 insertion regions; other site 1093787004565 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1093787004566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787004567 dimer interface [polypeptide binding]; other site 1093787004568 conserved gate region; other site 1093787004569 putative PBP binding loops; other site 1093787004570 ABC-ATPase subunit interface; other site 1093787004571 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1093787004572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787004573 Walker A/P-loop; other site 1093787004574 ATP binding site [chemical binding]; other site 1093787004575 Q-loop/lid; other site 1093787004576 ABC transporter signature motif; other site 1093787004577 Walker B; other site 1093787004578 D-loop; other site 1093787004579 H-loop/switch region; other site 1093787004580 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1093787004581 HopJ type III effector protein; Region: HopJ; pfam08888 1093787004582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 1093787004583 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1093787004584 homooctamer interface [polypeptide binding]; other site 1093787004585 active site 1093787004586 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1093787004587 homodecamer interface [polypeptide binding]; other site 1093787004588 GTP cyclohydrolase I; Provisional; Region: PLN03044 1093787004589 active site 1093787004590 putative catalytic site residues [active] 1093787004591 zinc binding site [ion binding]; other site 1093787004592 GTP-CH-I/GFRP interaction surface; other site 1093787004593 dihydromonapterin reductase; Provisional; Region: PRK06483 1093787004594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787004595 NAD(P) binding site [chemical binding]; other site 1093787004596 active site 1093787004597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1093787004598 flavodoxin; Provisional; Region: PRK05723 1093787004599 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787004600 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787004601 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1093787004602 putative dimerization interface [polypeptide binding]; other site 1093787004603 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1093787004604 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1093787004605 aldolase II superfamily protein; Provisional; Region: PRK07044 1093787004606 intersubunit interface [polypeptide binding]; other site 1093787004607 active site 1093787004608 Zn2+ binding site [ion binding]; other site 1093787004609 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1093787004610 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1093787004611 homodimer interface [polypeptide binding]; other site 1093787004612 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1093787004613 NAD binding site [chemical binding]; other site 1093787004614 active site 1093787004615 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1093787004616 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1093787004617 substrate binding site [chemical binding]; other site 1093787004618 oxyanion hole (OAH) forming residues; other site 1093787004619 trimer interface [polypeptide binding]; other site 1093787004620 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1093787004621 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1093787004622 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1093787004623 SnoaL-like domain; Region: SnoaL_2; pfam12680 1093787004624 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787004625 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787004626 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1093787004627 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1093787004628 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1093787004629 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787004630 DNA binding residues [nucleotide binding] 1093787004631 dimerization interface [polypeptide binding]; other site 1093787004632 Uncharacterized conserved protein [Function unknown]; Region: COG2912 1093787004633 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1093787004634 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1093787004635 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1093787004636 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1093787004637 NAD binding site [chemical binding]; other site 1093787004638 Phe binding site; other site 1093787004639 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1093787004640 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1093787004641 TPP-binding site [chemical binding]; other site 1093787004642 tetramer interface [polypeptide binding]; other site 1093787004643 heterodimer interface [polypeptide binding]; other site 1093787004644 phosphorylation loop region [posttranslational modification] 1093787004645 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1093787004646 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1093787004647 alpha subunit interface [polypeptide binding]; other site 1093787004648 TPP binding site [chemical binding]; other site 1093787004649 heterodimer interface [polypeptide binding]; other site 1093787004650 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1093787004651 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1093787004652 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1093787004653 E3 interaction surface; other site 1093787004654 lipoyl attachment site [posttranslational modification]; other site 1093787004655 e3 binding domain; Region: E3_binding; pfam02817 1093787004656 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1093787004657 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1093787004658 DNA damage-inducible gene in SOS regulon, dependent on cyclic AMP and H-NS , pqiA [General function prediction only]; Region: COG3141 1093787004659 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1093787004660 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1093787004661 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1093787004662 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1093787004663 DNA binding residues [nucleotide binding] 1093787004664 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1093787004665 FecR protein; Region: FecR; pfam04773 1093787004666 Secretin and TonB N terminus short domain; Region: STN; smart00965 1093787004667 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1093787004668 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787004669 N-terminal plug; other site 1093787004670 ligand-binding site [chemical binding]; other site 1093787004671 Heme-binding protein A (HasA); Region: HasA; pfam06438 1093787004672 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1093787004673 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1093787004674 Walker A/P-loop; other site 1093787004675 ATP binding site [chemical binding]; other site 1093787004676 Q-loop/lid; other site 1093787004677 ABC transporter signature motif; other site 1093787004678 Walker B; other site 1093787004679 D-loop; other site 1093787004680 H-loop/switch region; other site 1093787004681 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1093787004682 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787004683 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787004684 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1093787004685 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1093787004686 Predicted membrane protein [Function unknown]; Region: COG3223 1093787004687 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787004688 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787004689 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1093787004690 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1093787004691 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1093787004692 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1093787004693 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1093787004694 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 1093787004695 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1093787004696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787004697 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1093787004698 putative dimerization interface [polypeptide binding]; other site 1093787004699 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1093787004700 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1093787004701 FAD binding pocket [chemical binding]; other site 1093787004702 FAD binding motif [chemical binding]; other site 1093787004703 phosphate binding motif [ion binding]; other site 1093787004704 beta-alpha-beta structure motif; other site 1093787004705 NAD binding pocket [chemical binding]; other site 1093787004706 NosL; Region: NosL; cl01769 1093787004707 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1093787004708 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1093787004709 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1093787004710 Walker A/P-loop; other site 1093787004711 ATP binding site [chemical binding]; other site 1093787004712 Q-loop/lid; other site 1093787004713 ABC transporter signature motif; other site 1093787004714 Walker B; other site 1093787004715 D-loop; other site 1093787004716 H-loop/switch region; other site 1093787004717 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 1093787004718 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1093787004719 nitrous-oxide reductase; Validated; Region: PRK02888 1093787004720 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1093787004721 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 1093787004722 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 1093787004723 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1093787004724 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1093787004725 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1093787004726 active site 1093787004727 metal binding site [ion binding]; metal-binding site 1093787004728 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1093787004729 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1093787004730 homodimer interaction site [polypeptide binding]; other site 1093787004731 cofactor binding site; other site 1093787004732 RhlG and related beta-ketoacyl reductases, classical (c) SDRs; Region: RhlG_SDR_c; cd08942 1093787004733 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1093787004734 NADP binding site [chemical binding]; other site 1093787004735 active site 1093787004736 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1093787004737 Arc-like DNA binding domain; Region: Arc; pfam03869 1093787004738 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1093787004739 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1093787004740 Walker A/P-loop; other site 1093787004741 ATP binding site [chemical binding]; other site 1093787004742 Q-loop/lid; other site 1093787004743 ABC transporter signature motif; other site 1093787004744 Walker B; other site 1093787004745 D-loop; other site 1093787004746 H-loop/switch region; other site 1093787004747 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1093787004748 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1093787004749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787004750 dimer interface [polypeptide binding]; other site 1093787004751 conserved gate region; other site 1093787004752 ABC-ATPase subunit interface; other site 1093787004753 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1093787004754 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787004755 DNA-binding site [nucleotide binding]; DNA binding site 1093787004756 UTRA domain; Region: UTRA; pfam07702 1093787004757 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 1093787004758 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; cl01455 1093787004759 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 1093787004760 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 1093787004761 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 1093787004762 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787004763 Walker A/P-loop; other site 1093787004764 ATP binding site [chemical binding]; other site 1093787004765 Q-loop/lid; other site 1093787004766 ABC transporter signature motif; other site 1093787004767 Walker B; other site 1093787004768 D-loop; other site 1093787004769 H-loop/switch region; other site 1093787004770 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1093787004771 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 1093787004772 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787004773 Walker A/P-loop; other site 1093787004774 ATP binding site [chemical binding]; other site 1093787004775 Q-loop/lid; other site 1093787004776 ABC transporter signature motif; other site 1093787004777 Walker B; other site 1093787004778 D-loop; other site 1093787004779 H-loop/switch region; other site 1093787004780 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 1093787004781 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1093787004782 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 1093787004783 active site 1093787004784 Uncharacterized component of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3709 1093787004785 AAA domain; Region: AAA_18; pfam13238 1093787004786 active site 1093787004787 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 1093787004788 putative hydrolase; Provisional; Region: PRK02113 1093787004789 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 1093787004790 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1093787004791 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787004792 Coenzyme A binding pocket [chemical binding]; other site 1093787004793 hypothetical protein; Provisional; Region: PRK10040 1093787004794 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 1093787004795 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 1093787004796 multimer interface [polypeptide binding]; other site 1093787004797 active site 1093787004798 catalytic triad [active] 1093787004799 dimer interface [polypeptide binding]; other site 1093787004800 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1093787004801 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787004802 Walker A motif; other site 1093787004803 ATP binding site [chemical binding]; other site 1093787004804 Walker B motif; other site 1093787004805 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1093787004806 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 1093787004807 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1093787004808 ligand binding site [chemical binding]; other site 1093787004809 regulator interaction site; other site 1093787004810 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1093787004811 ANTAR domain; Region: ANTAR; pfam03861 1093787004812 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 1093787004813 Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472 1093787004814 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1093787004815 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787004816 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787004817 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 1093787004818 EamA-like transporter family; Region: EamA; cl17759 1093787004819 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1093787004820 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1093787004821 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1093787004822 catalytic residue [active] 1093787004823 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1093787004824 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1093787004825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787004826 putative substrate translocation pore; other site 1093787004827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 1093787004828 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1093787004829 Flagellar regulator YcgR; Region: YcgR; pfam07317 1093787004830 PilZ domain; Region: PilZ; pfam07238 1093787004831 Flagellar biosynthesis/type III secretory pathway chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3418 1093787004832 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 1093787004833 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 1093787004834 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1093787004835 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1093787004836 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1093787004837 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1093787004838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787004839 active site 1093787004840 phosphorylation site [posttranslational modification] 1093787004841 intermolecular recognition site; other site 1093787004842 dimerization interface [polypeptide binding]; other site 1093787004843 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1093787004844 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1093787004845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787004846 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1093787004847 anti sigma factor interaction site; other site 1093787004848 regulatory phosphorylation site [posttranslational modification]; other site 1093787004849 Response regulator receiver domain; Region: Response_reg; pfam00072 1093787004850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787004851 active site 1093787004852 phosphorylation site [posttranslational modification] 1093787004853 intermolecular recognition site; other site 1093787004854 dimerization interface [polypeptide binding]; other site 1093787004855 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1093787004856 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1093787004857 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1093787004858 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1093787004859 putative binding surface; other site 1093787004860 active site 1093787004861 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1093787004862 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1093787004863 ATP binding site [chemical binding]; other site 1093787004864 putative Mg++ binding site [ion binding]; other site 1093787004865 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1093787004866 nucleotide binding region [chemical binding]; other site 1093787004867 ATP-binding site [chemical binding]; other site 1093787004868 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1093787004869 HRDC domain; Region: HRDC; pfam00570 1093787004870 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787004871 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787004872 metal binding site [ion binding]; metal-binding site 1093787004873 active site 1093787004874 I-site; other site 1093787004875 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 1093787004876 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1093787004877 MarR family; Region: MarR_2; pfam12802 1093787004878 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 1093787004879 FimV N-terminal domain; Region: FimV_core; TIGR03505 1093787004880 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 1093787004881 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 1093787004882 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1093787004883 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1093787004884 active site 1093787004885 nucleophile elbow; other site 1093787004886 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1093787004887 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1093787004888 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1093787004889 Surface antigen; Region: Bac_surface_Ag; pfam01103 1093787004890 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 1093787004891 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 1093787004892 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1093787004893 NADP binding site [chemical binding]; other site 1093787004894 homopentamer interface [polypeptide binding]; other site 1093787004895 substrate binding site [chemical binding]; other site 1093787004896 active site 1093787004897 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1093787004898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787004899 putative substrate translocation pore; other site 1093787004900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787004901 S-adenosylmethionine binding site [chemical binding]; other site 1093787004902 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1093787004903 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1093787004904 dimer interface [polypeptide binding]; other site 1093787004905 active site 1093787004906 CoA binding pocket [chemical binding]; other site 1093787004907 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1093787004908 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1093787004909 Cytochrome P450; Region: p450; cl12078 1093787004910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787004911 short chain dehydrogenase; Provisional; Region: PRK06914 1093787004912 NAD(P) binding site [chemical binding]; other site 1093787004913 active site 1093787004914 Condensation domain; Region: Condensation; pfam00668 1093787004915 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1093787004916 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1093787004917 Condensation domain; Region: Condensation; pfam00668 1093787004918 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1093787004919 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1093787004920 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1093787004921 acyl-activating enzyme (AAE) consensus motif; other site 1093787004922 AMP binding site [chemical binding]; other site 1093787004923 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1093787004924 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1093787004925 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1093787004926 acyl-activating enzyme (AAE) consensus motif; other site 1093787004927 AMP binding site [chemical binding]; other site 1093787004928 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1093787004929 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1093787004930 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1093787004931 oligomer interface [polypeptide binding]; other site 1093787004932 active site residues [active] 1093787004933 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1093787004934 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1093787004935 short chain dehydrogenase; Validated; Region: PRK05855 1093787004936 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1093787004937 classical (c) SDRs; Region: SDR_c; cd05233 1093787004938 NAD(P) binding site [chemical binding]; other site 1093787004939 active site 1093787004940 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1093787004941 active site 1093787004942 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 1093787004943 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1093787004944 DNA binding residues [nucleotide binding] 1093787004945 putative dimer interface [polypeptide binding]; other site 1093787004946 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787004947 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787004948 The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465 1093787004949 putative substrate binding pocket [chemical binding]; other site 1093787004950 putative dimerization interface [polypeptide binding]; other site 1093787004951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1093787004952 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1093787004953 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1093787004954 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1093787004955 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1093787004956 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1093787004957 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 1093787004958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1093787004959 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1093787004960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787004961 Walker A/P-loop; other site 1093787004962 ATP binding site [chemical binding]; other site 1093787004963 Q-loop/lid; other site 1093787004964 ABC transporter signature motif; other site 1093787004965 Walker B; other site 1093787004966 D-loop; other site 1093787004967 H-loop/switch region; other site 1093787004968 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1093787004969 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787004970 substrate binding pocket [chemical binding]; other site 1093787004971 membrane-bound complex binding site; other site 1093787004972 hinge residues; other site 1093787004973 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1093787004974 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1093787004975 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1093787004976 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1093787004977 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1093787004978 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787004979 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787004980 metal binding site [ion binding]; metal-binding site 1093787004981 active site 1093787004982 I-site; other site 1093787004983 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1093787004984 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1093787004985 Sulfatase; Region: Sulfatase; pfam00884 1093787004986 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1093787004987 Ligand Binding Site [chemical binding]; other site 1093787004988 ATP-dependent helicase HepA; Validated; Region: PRK04914 1093787004989 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1093787004990 ATP binding site [chemical binding]; other site 1093787004991 putative Mg++ binding site [ion binding]; other site 1093787004992 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1093787004993 nucleotide binding region [chemical binding]; other site 1093787004994 ATP-binding site [chemical binding]; other site 1093787004995 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1093787004996 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1093787004997 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1093787004998 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1093787004999 HlyD family secretion protein; Region: HlyD; pfam00529 1093787005000 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787005001 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787005002 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1093787005003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1093787005004 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1093787005005 dimer interaction site [polypeptide binding]; other site 1093787005006 substrate-binding tunnel; other site 1093787005007 active site 1093787005008 catalytic site [active] 1093787005009 substrate binding site [chemical binding]; other site 1093787005010 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1093787005011 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1093787005012 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1093787005013 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492 1093787005014 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1093787005015 acyl-activating enzyme (AAE) consensus motif; other site 1093787005016 putative AMP binding site [chemical binding]; other site 1093787005017 putative active site [active] 1093787005018 putative CoA binding site [chemical binding]; other site 1093787005019 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 1093787005020 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1093787005021 acyl-activating enzyme (AAE) consensus motif; other site 1093787005022 putative AMP binding site [chemical binding]; other site 1093787005023 putative active site [active] 1093787005024 putative CoA binding site [chemical binding]; other site 1093787005025 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1093787005026 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1093787005027 ATP binding site [chemical binding]; other site 1093787005028 putative Mg++ binding site [ion binding]; other site 1093787005029 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1093787005030 nucleotide binding region [chemical binding]; other site 1093787005031 ATP-binding site [chemical binding]; other site 1093787005032 Helicase associated domain (HA2); Region: HA2; pfam04408 1093787005033 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1093787005034 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1093787005035 alkaline phosphatase; Provisional; Region: PRK10518 1093787005036 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1093787005037 active site 1093787005038 dimer interface [polypeptide binding]; other site 1093787005039 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1093787005040 HIT family signature motif; other site 1093787005041 catalytic residue [active] 1093787005042 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1093787005043 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1093787005044 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1093787005045 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1093787005046 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1093787005047 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1093787005048 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1093787005049 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 1093787005050 Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335 1093787005051 Isochorismatase family; Region: Isochorismatase; pfam00857 1093787005052 catalytic triad [active] 1093787005053 conserved cis-peptide bond; other site 1093787005054 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1093787005055 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1093787005056 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1093787005057 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 1093787005058 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1093787005059 dimer interface [polypeptide binding]; other site 1093787005060 active site 1093787005061 CoA binding pocket [chemical binding]; other site 1093787005062 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1093787005063 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1093787005064 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1093787005065 DNA binding residues [nucleotide binding] 1093787005066 Putative zinc-finger; Region: zf-HC2; pfam13490 1093787005067 Uncharacterized low-complexity protein [Function unknown]; Region: COG3767 1093787005068 Protein of unknown function (DUF692); Region: DUF692; pfam05114 1093787005069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3219 1093787005070 Predicted membrane protein [Function unknown]; Region: COG2259 1093787005071 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 1093787005072 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 1093787005073 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 1093787005074 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 1093787005075 short chain dehydrogenase; Provisional; Region: PRK05650 1093787005076 classical (c) SDRs; Region: SDR_c; cd05233 1093787005077 NAD(P) binding site [chemical binding]; other site 1093787005078 active site 1093787005079 Uncharacterized conserved protein [Function unknown]; Region: COG1742 1093787005080 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1093787005081 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1093787005082 ATP binding site [chemical binding]; other site 1093787005083 putative Mg++ binding site [ion binding]; other site 1093787005084 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1093787005085 nucleotide binding region [chemical binding]; other site 1093787005086 ATP-binding site [chemical binding]; other site 1093787005087 DEAD/H associated; Region: DEAD_assoc; pfam08494 1093787005088 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1093787005089 Na binding site [ion binding]; other site 1093787005090 PAS fold; Region: PAS_7; pfam12860 1093787005091 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1093787005092 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787005093 dimer interface [polypeptide binding]; other site 1093787005094 phosphorylation site [posttranslational modification] 1093787005095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787005096 ATP binding site [chemical binding]; other site 1093787005097 Mg2+ binding site [ion binding]; other site 1093787005098 G-X-G motif; other site 1093787005099 Response regulator receiver domain; Region: Response_reg; pfam00072 1093787005100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787005101 active site 1093787005102 phosphorylation site [posttranslational modification] 1093787005103 intermolecular recognition site; other site 1093787005104 dimerization interface [polypeptide binding]; other site 1093787005105 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1093787005106 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1093787005107 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1093787005108 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787005109 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787005110 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787005111 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1093787005112 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787005113 N-terminal plug; other site 1093787005114 ligand-binding site [chemical binding]; other site 1093787005115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787005116 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1093787005117 putative substrate translocation pore; other site 1093787005118 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1093787005119 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1093787005120 putative acyl-acceptor binding pocket; other site 1093787005121 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1093787005122 DNA-binding site [nucleotide binding]; DNA binding site 1093787005123 RNA-binding motif; other site 1093787005124 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1093787005125 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1093787005126 Sodium Bile acid symporter family; Region: SBF; pfam01758 1093787005127 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1093787005128 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1093787005129 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1093787005130 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1093787005131 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1093787005132 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1093787005133 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787005134 substrate binding pocket [chemical binding]; other site 1093787005135 membrane-bound complex binding site; other site 1093787005136 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1093787005137 non-specific DNA binding site [nucleotide binding]; other site 1093787005138 salt bridge; other site 1093787005139 sequence-specific DNA binding site [nucleotide binding]; other site 1093787005140 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 1093787005141 Domain of unknown function (DUF955); Region: DUF955; cl01076 1093787005142 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 1093787005143 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1093787005144 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 1093787005145 carboxy-terminal protease; Provisional; Region: PRK11186 1093787005146 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1093787005147 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1093787005148 protein binding site [polypeptide binding]; other site 1093787005149 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1093787005150 Catalytic dyad [active] 1093787005151 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1093787005152 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1093787005153 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1093787005154 NAD(P) binding site [chemical binding]; other site 1093787005155 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1093787005156 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1093787005157 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1093787005158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787005159 Walker A/P-loop; other site 1093787005160 ATP binding site [chemical binding]; other site 1093787005161 Q-loop/lid; other site 1093787005162 ABC transporter signature motif; other site 1093787005163 Walker B; other site 1093787005164 D-loop; other site 1093787005165 H-loop/switch region; other site 1093787005166 TOBE domain; Region: TOBE_2; pfam08402 1093787005167 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1093787005168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787005169 dimer interface [polypeptide binding]; other site 1093787005170 conserved gate region; other site 1093787005171 putative PBP binding loops; other site 1093787005172 ABC-ATPase subunit interface; other site 1093787005173 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1093787005174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787005175 dimer interface [polypeptide binding]; other site 1093787005176 conserved gate region; other site 1093787005177 putative PBP binding loops; other site 1093787005178 ABC-ATPase subunit interface; other site 1093787005179 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 1093787005180 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1093787005181 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1093787005182 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787005183 DNA-binding site [nucleotide binding]; DNA binding site 1093787005184 transcriptional regulator protein; Region: phnR; TIGR03337 1093787005185 UTRA domain; Region: UTRA; pfam07702 1093787005186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1093787005187 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1093787005188 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1093787005189 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1093787005190 active site 1093787005191 metal binding site [ion binding]; metal-binding site 1093787005192 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1093787005193 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1093787005194 active site 1093787005195 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1093787005196 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1093787005197 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1093787005198 Switch I; other site 1093787005199 Switch II; other site 1093787005200 septum formation inhibitor; Reviewed; Region: minC; PRK00339 1093787005201 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1093787005202 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1093787005203 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1093787005204 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1093787005205 putative acyl-acceptor binding pocket; other site 1093787005206 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1093787005207 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1093787005208 active site 1093787005209 nucleophile elbow; other site 1093787005210 Pirin-related protein [General function prediction only]; Region: COG1741 1093787005211 Pirin; Region: Pirin; pfam02678 1093787005212 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1093787005213 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 1093787005214 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1093787005215 Predicted membrane protein [Function unknown]; Region: COG3205 1093787005216 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1093787005217 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1093787005218 Predicted membrane protein [Function unknown]; Region: COG3162 1093787005219 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1093787005220 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1093787005221 Na binding site [ion binding]; other site 1093787005222 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1093787005223 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1093787005224 ligand binding site [chemical binding]; other site 1093787005225 flexible hinge region; other site 1093787005226 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain. Members of CAP_ED, include CAP...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589 1093787005227 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1093787005228 metal binding triad; other site 1093787005229 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1093787005230 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1093787005231 active site 1093787005232 catalytic site [active] 1093787005233 substrate binding site [chemical binding]; other site 1093787005234 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 1093787005235 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1093787005236 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1093787005237 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1093787005238 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1093787005239 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1093787005240 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1093787005241 Walker A/P-loop; other site 1093787005242 ATP binding site [chemical binding]; other site 1093787005243 Q-loop/lid; other site 1093787005244 ABC transporter signature motif; other site 1093787005245 Walker B; other site 1093787005246 D-loop; other site 1093787005247 H-loop/switch region; other site 1093787005248 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1093787005249 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1093787005250 substrate binding site [chemical binding]; other site 1093787005251 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1093787005252 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1093787005253 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1093787005254 catalytic site [active] 1093787005255 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787005256 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787005257 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787005258 dimerization interface [polypeptide binding]; other site 1093787005259 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1093787005260 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1093787005261 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1093787005262 EamA-like transporter family; Region: EamA; pfam00892 1093787005263 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1093787005264 dimer interface [polypeptide binding]; other site 1093787005265 putative tRNA-binding site [nucleotide binding]; other site 1093787005266 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787005267 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787005268 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787005269 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1093787005270 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1093787005271 putative active site [active] 1093787005272 putative metal binding site [ion binding]; other site 1093787005273 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1093787005274 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1093787005275 MASE2 domain; Region: MASE2; pfam05230 1093787005276 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1093787005277 cyclase homology domain; Region: CHD; cd07302 1093787005278 nucleotidyl binding site; other site 1093787005279 metal binding site [ion binding]; metal-binding site 1093787005280 dimer interface [polypeptide binding]; other site 1093787005281 Predicted membrane protein [Function unknown]; Region: COG4323 1093787005282 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1093787005283 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787005284 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787005285 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 1093787005286 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1093787005287 mce related protein; Region: MCE; pfam02470 1093787005288 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1093787005289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787005290 Walker A/P-loop; other site 1093787005291 ATP binding site [chemical binding]; other site 1093787005292 Q-loop/lid; other site 1093787005293 ABC transporter signature motif; other site 1093787005294 Walker B; other site 1093787005295 D-loop; other site 1093787005296 H-loop/switch region; other site 1093787005297 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1093787005298 Permease; Region: Permease; pfam02405 1093787005299 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1093787005300 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1093787005301 Flagellin N-methylase; Region: FliB; cl00497 1093787005302 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1093787005303 putative FMN binding site [chemical binding]; other site 1093787005304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1093787005305 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787005306 dimerization interface [polypeptide binding]; other site 1093787005307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787005308 ATP binding site [chemical binding]; other site 1093787005309 Mg2+ binding site [ion binding]; other site 1093787005310 G-X-G motif; other site 1093787005311 P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein [Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism]; Region: CpxP; COG3678 1093787005312 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1093787005313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787005314 active site 1093787005315 phosphorylation site [posttranslational modification] 1093787005316 intermolecular recognition site; other site 1093787005317 dimerization interface [polypeptide binding]; other site 1093787005318 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787005319 DNA binding site [nucleotide binding] 1093787005320 YciI-like protein; Reviewed; Region: PRK11370 1093787005321 intracellular septation protein A; Reviewed; Region: PRK00259 1093787005322 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1093787005323 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1093787005324 active site 1093787005325 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1093787005326 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1093787005327 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1093787005328 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1093787005329 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1093787005330 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1093787005331 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1093787005332 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1093787005333 phosphogluconate dehydratase; Validated; Region: PRK09054 1093787005334 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1093787005335 glucokinase, proteobacterial type; Region: glk; TIGR00749 1093787005336 glucokinase; Provisional; Region: glk; PRK00292 1093787005337 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1093787005338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787005339 active site 1093787005340 phosphorylation site [posttranslational modification] 1093787005341 intermolecular recognition site; other site 1093787005342 dimerization interface [polypeptide binding]; other site 1093787005343 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787005344 DNA binding site [nucleotide binding] 1093787005345 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1093787005346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787005347 ATP binding site [chemical binding]; other site 1093787005348 Mg2+ binding site [ion binding]; other site 1093787005349 G-X-G motif; other site 1093787005350 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1093787005351 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1093787005352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787005353 dimer interface [polypeptide binding]; other site 1093787005354 conserved gate region; other site 1093787005355 putative PBP binding loops; other site 1093787005356 ABC-ATPase subunit interface; other site 1093787005357 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1093787005358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787005359 dimer interface [polypeptide binding]; other site 1093787005360 conserved gate region; other site 1093787005361 putative PBP binding loops; other site 1093787005362 ABC-ATPase subunit interface; other site 1093787005363 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1093787005364 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1093787005365 Walker A/P-loop; other site 1093787005366 ATP binding site [chemical binding]; other site 1093787005367 Q-loop/lid; other site 1093787005368 ABC transporter signature motif; other site 1093787005369 Walker B; other site 1093787005370 D-loop; other site 1093787005371 H-loop/switch region; other site 1093787005372 TOBE domain; Region: TOBE; pfam03459 1093787005373 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 1093787005374 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1093787005375 active site 1093787005376 phosphate binding residues; other site 1093787005377 catalytic residues [active] 1093787005378 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1093787005379 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1093787005380 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1093787005381 putative active site [active] 1093787005382 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1093787005383 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1093787005384 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1093787005385 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1093787005386 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1093787005387 putative active site [active] 1093787005388 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1093787005389 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1093787005390 active site 1093787005391 intersubunit interface [polypeptide binding]; other site 1093787005392 catalytic residue [active] 1093787005393 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 1093787005394 nudix motif; other site 1093787005395 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1093787005396 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1093787005397 RNA binding surface [nucleotide binding]; other site 1093787005398 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1093787005399 probable active site [active] 1093787005400 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787005401 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787005402 metal binding site [ion binding]; metal-binding site 1093787005403 active site 1093787005404 I-site; other site 1093787005405 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 1093787005406 agmatinase; Region: agmatinase; TIGR01230 1093787005407 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1093787005408 putative active site [active] 1093787005409 putative metal binding site [ion binding]; other site 1093787005410 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1093787005411 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1093787005412 Bacterial transcriptional regulator; Region: IclR; pfam01614 1093787005413 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1093787005414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787005415 NAD(P) binding site [chemical binding]; other site 1093787005416 active site 1093787005417 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1093787005418 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1093787005419 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1093787005420 motif II; other site 1093787005421 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1093787005422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787005423 S-adenosylmethionine binding site [chemical binding]; other site 1093787005424 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 1093787005425 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1093787005426 active site 1093787005427 putative substrate binding pocket [chemical binding]; other site 1093787005428 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1093787005429 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 1093787005430 DNA gyrase subunit A; Validated; Region: PRK05560 1093787005431 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1093787005432 CAP-like domain; other site 1093787005433 active site 1093787005434 primary dimer interface [polypeptide binding]; other site 1093787005435 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1093787005436 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1093787005437 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1093787005438 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1093787005439 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1093787005440 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1093787005441 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1093787005442 homodimer interface [polypeptide binding]; other site 1093787005443 substrate-cofactor binding pocket; other site 1093787005444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787005445 catalytic residue [active] 1093787005446 Chorismate mutase type II; Region: CM_2; cl00693 1093787005447 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1093787005448 Prephenate dehydratase; Region: PDT; pfam00800 1093787005449 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1093787005450 putative L-Phe binding site [chemical binding]; other site 1093787005451 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1093787005452 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1093787005453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787005454 homodimer interface [polypeptide binding]; other site 1093787005455 catalytic residue [active] 1093787005456 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 1093787005457 prephenate dehydrogenase; Validated; Region: PRK08507 1093787005458 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1093787005459 hinge; other site 1093787005460 active site 1093787005461 cytidylate kinase; Provisional; Region: cmk; PRK00023 1093787005462 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1093787005463 CMP-binding site; other site 1093787005464 The sites determining sugar specificity; other site 1093787005465 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1093787005466 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1093787005467 RNA binding site [nucleotide binding]; other site 1093787005468 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1093787005469 RNA binding site [nucleotide binding]; other site 1093787005470 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1093787005471 RNA binding site [nucleotide binding]; other site 1093787005472 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1093787005473 RNA binding site [nucleotide binding]; other site 1093787005474 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1093787005475 RNA binding site [nucleotide binding]; other site 1093787005476 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1093787005477 RNA binding site [nucleotide binding]; other site 1093787005478 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1093787005479 IHF dimer interface [polypeptide binding]; other site 1093787005480 IHF - DNA interface [nucleotide binding]; other site 1093787005481 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 1093787005482 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 1093787005483 Chain length determinant protein; Region: Wzz; pfam02706 1093787005484 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1093787005485 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1093787005486 homodimer interface [polypeptide binding]; other site 1093787005487 active site 1093787005488 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1093787005489 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1093787005490 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1093787005491 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1093787005492 Transposase; Region: HTH_Tnp_1; pfam01527 1093787005493 HTH-like domain; Region: HTH_21; pfam13276 1093787005494 Integrase core domain; Region: rve; pfam00665 1093787005495 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1093787005496 Integrase core domain; Region: rve_3; pfam13683 1093787005497 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1093787005498 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1093787005499 Probable Catalytic site; other site 1093787005500 metal-binding site 1093787005501 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1093787005502 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1093787005503 putative NAD(P) binding site [chemical binding]; other site 1093787005504 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1093787005505 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1093787005506 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1093787005507 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 1093787005508 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1093787005509 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1093787005510 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1093787005511 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1093787005512 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1093787005513 putative trimer interface [polypeptide binding]; other site 1093787005514 putative CoA binding site [chemical binding]; other site 1093787005515 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1093787005516 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1093787005517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787005518 inhibitor-cofactor binding pocket; inhibition site 1093787005519 catalytic residue [active] 1093787005520 potential frameshift: common BLAST hit: gi|15598341|ref|NP_251835.1| glycosyltransferase WbpL 1093787005521 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 1093787005522 Mg++ binding site [ion binding]; other site 1093787005523 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1093787005524 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 1093787005525 putative catalytic motif [active] 1093787005526 putative substrate binding site [chemical binding]; other site 1093787005527 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1093787005528 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1093787005529 NAD(P) binding site [chemical binding]; other site 1093787005530 homodimer interface [polypeptide binding]; other site 1093787005531 substrate binding site [chemical binding]; other site 1093787005532 active site 1093787005533 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1093787005534 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1093787005535 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1093787005536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787005537 homodimer interface [polypeptide binding]; other site 1093787005538 catalytic residue [active] 1093787005539 excinuclease ABC subunit B; Provisional; Region: PRK05298 1093787005540 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1093787005541 ATP binding site [chemical binding]; other site 1093787005542 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1093787005543 nucleotide binding region [chemical binding]; other site 1093787005544 ATP-binding site [chemical binding]; other site 1093787005545 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1093787005546 UvrB/uvrC motif; Region: UVR; pfam02151 1093787005547 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1093787005548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787005549 putative substrate translocation pore; other site 1093787005550 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1093787005551 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787005552 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787005553 LysR family transcriptional regulator; Provisional; Region: PRK14997 1093787005554 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787005555 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1093787005556 putative effector binding pocket; other site 1093787005557 dimerization interface [polypeptide binding]; other site 1093787005558 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1093787005559 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1093787005560 HIGH motif; other site 1093787005561 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1093787005562 active site 1093787005563 KMSKS motif; other site 1093787005564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787005565 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787005566 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1093787005567 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1093787005568 Entner-Doudoroff aldolase; Region: eda; TIGR01182 1093787005569 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1093787005570 active site 1093787005571 intersubunit interface [polypeptide binding]; other site 1093787005572 catalytic residue [active] 1093787005573 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1093787005574 active site 1093787005575 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1093787005576 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1093787005577 FMN binding site [chemical binding]; other site 1093787005578 active site 1093787005579 catalytic residues [active] 1093787005580 substrate binding site [chemical binding]; other site 1093787005581 short chain dehydrogenase; Provisional; Region: PRK06123 1093787005582 classical (c) SDRs; Region: SDR_c; cd05233 1093787005583 NAD(P) binding site [chemical binding]; other site 1093787005584 active site 1093787005585 BLMT, a bleomycin resistance protein encoded on the transposon Tn5, and similar proteins; Region: BLMT_like; cd08350 1093787005586 dimer interface [polypeptide binding]; other site 1093787005587 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1093787005588 ligand binding site [chemical binding]; other site 1093787005589 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787005590 Coenzyme A binding pocket [chemical binding]; other site 1093787005591 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1093787005592 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1093787005593 putative dimer interface [polypeptide binding]; other site 1093787005594 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 1093787005595 active site 1093787005596 catalytic triad [active] 1093787005597 oxyanion hole [active] 1093787005598 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787005599 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787005600 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_10; cd08480 1093787005601 putative effector binding pocket; other site 1093787005602 putative dimerization interface [polypeptide binding]; other site 1093787005603 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1093787005604 homotrimer interaction site [polypeptide binding]; other site 1093787005605 putative active site [active] 1093787005606 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787005607 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787005608 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1093787005609 dimerization interface [polypeptide binding]; other site 1093787005610 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1093787005611 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1093787005612 substrate binding site [chemical binding]; other site 1093787005613 ligand binding site [chemical binding]; other site 1093787005614 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1093787005615 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1093787005616 substrate binding site [chemical binding]; other site 1093787005617 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1093787005618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787005619 S-adenosylmethionine binding site [chemical binding]; other site 1093787005620 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1093787005621 tartrate dehydrogenase; Region: TTC; TIGR02089 1093787005622 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1093787005623 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1093787005624 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671 1093787005625 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1093787005626 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 1093787005627 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1093787005628 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 1093787005629 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1093787005630 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1093787005631 dimerization interface 3.5A [polypeptide binding]; other site 1093787005632 active site 1093787005633 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1093787005634 active site 1093787005635 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1093787005636 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1093787005637 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1093787005638 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1093787005639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 1093787005640 Sporulation related domain; Region: SPOR; pfam05036 1093787005641 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1093787005642 Colicin V production protein; Region: Colicin_V; pfam02674 1093787005643 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1093787005644 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1093787005645 active site 1093787005646 tetramer interface [polypeptide binding]; other site 1093787005647 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1093787005648 active site 1093787005649 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 1093787005650 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1093787005651 homodimer interface [polypeptide binding]; other site 1093787005652 substrate-cofactor binding pocket; other site 1093787005653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787005654 catalytic residue [active] 1093787005655 oxidoreductase; Validated; Region: PRK05717 1093787005656 Clostridium thermocellum A3DFK9-like, a putative carbohydrate or polyalcohol metabolizing SDR, classical (c) SDRs; Region: A3DFK9-like_SDR_c; cd09761 1093787005657 NAD binding site [chemical binding]; other site 1093787005658 active site 1093787005659 homodimer interface [polypeptide binding]; other site 1093787005660 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 1093787005661 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1093787005662 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1093787005663 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1093787005664 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1093787005665 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1093787005666 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1093787005667 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1093787005668 Walker A motif; other site 1093787005669 ATP binding site [chemical binding]; other site 1093787005670 Walker B motif; other site 1093787005671 type II secretion system protein F; Region: GspF; TIGR02120 1093787005672 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1093787005673 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1093787005674 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1093787005675 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1093787005676 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1093787005677 type II secretion system protein I; Region: gspI; TIGR01707 1093787005678 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1093787005679 type II secretion system protein J; Region: gspJ; TIGR01711 1093787005680 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1093787005681 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 1093787005682 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 1093787005683 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 1093787005684 GspL periplasmic domain; Region: GspL_C; pfam12693 1093787005685 Type II secretory pathway, component PulM [Intracellular trafficking and secretion]; Region: PulM; COG3149 1093787005686 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1093787005687 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787005688 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787005689 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1093787005690 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1093787005691 active site 1093787005692 catalytic triad [active] 1093787005693 dimer interface [polypeptide binding]; other site 1093787005694 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1093787005695 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1093787005696 active site 1093787005697 FMN binding site [chemical binding]; other site 1093787005698 2,4-decadienoyl-CoA binding site; other site 1093787005699 catalytic residue [active] 1093787005700 4Fe-4S cluster binding site [ion binding]; other site 1093787005701 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1093787005702 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 1093787005703 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 1093787005704 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 1093787005705 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1093787005706 Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413 1093787005707 active site 1093787005708 metal binding site [ion binding]; metal-binding site 1093787005709 Rhomboid family; Region: Rhomboid; pfam01694 1093787005710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 1093787005711 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 1093787005712 aminopeptidase N; Provisional; Region: pepN; PRK14015 1093787005713 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1093787005714 active site 1093787005715 Zn binding site [ion binding]; other site 1093787005716 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1093787005717 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1093787005718 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1093787005719 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1093787005720 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1093787005721 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787005722 dimer interface [polypeptide binding]; other site 1093787005723 phosphorylation site [posttranslational modification] 1093787005724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787005725 ATP binding site [chemical binding]; other site 1093787005726 Mg2+ binding site [ion binding]; other site 1093787005727 G-X-G motif; other site 1093787005728 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1093787005729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787005730 active site 1093787005731 phosphorylation site [posttranslational modification] 1093787005732 intermolecular recognition site; other site 1093787005733 dimerization interface [polypeptide binding]; other site 1093787005734 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787005735 DNA binding site [nucleotide binding] 1093787005736 chlorophyllase; Region: PLN00021 1093787005737 Oxygen tolerance; Region: BatD; pfam13584 1093787005738 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1093787005739 metal ion-dependent adhesion site (MIDAS); other site 1093787005740 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1093787005741 TPR repeat; Region: TPR_11; pfam13414 1093787005742 binding surface 1093787005743 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1093787005744 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1093787005745 metal ion-dependent adhesion site (MIDAS); other site 1093787005746 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 1093787005747 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1093787005748 Protein of unknown function DUF58; Region: DUF58; pfam01882 1093787005749 MoxR-like ATPases [General function prediction only]; Region: COG0714 1093787005750 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 1093787005751 Walker A motif; other site 1093787005752 ATP binding site [chemical binding]; other site 1093787005753 Walker B motif; other site 1093787005754 arginine finger; other site 1093787005755 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1093787005756 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 1093787005757 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1093787005758 MarR family; Region: MarR_2; pfam12802 1093787005759 Isochorismatase family; Region: Isochorismatase; pfam00857 1093787005760 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1093787005761 catalytic triad [active] 1093787005762 conserved cis-peptide bond; other site 1093787005763 Uncharacterized conserved protein [Function unknown]; Region: COG3868 1093787005764 C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922 1093787005765 putative active site [active] 1093787005766 Tetratricopeptide repeat; Region: TPR_15; pfam13429 1093787005767 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1093787005768 GAF domain; Region: GAF_3; pfam13492 1093787005769 HEAT repeats; Region: HEAT_2; pfam13646 1093787005770 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 1093787005771 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1093787005772 Predicted membrane protein [Function unknown]; Region: COG4267 1093787005773 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1093787005774 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1093787005775 non-specific DNA binding site [nucleotide binding]; other site 1093787005776 salt bridge; other site 1093787005777 sequence-specific DNA binding site [nucleotide binding]; other site 1093787005778 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1093787005779 non-specific DNA binding site [nucleotide binding]; other site 1093787005780 salt bridge; other site 1093787005781 sequence-specific DNA binding site [nucleotide binding]; other site 1093787005782 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1093787005783 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 1093787005784 putative active site [active] 1093787005785 Zn binding site [ion binding]; other site 1093787005786 potential frameshift: common BLAST hit: gi|15598249|ref|NP_251743.1| hydrolytic enzyme 1093787005787 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 1093787005788 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1093787005789 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1093787005790 quinone interaction residues [chemical binding]; other site 1093787005791 active site 1093787005792 catalytic residues [active] 1093787005793 FMN binding site [chemical binding]; other site 1093787005794 substrate binding site [chemical binding]; other site 1093787005795 Ribosome modulation factor [Translation, ribosomal structure and biogenesis]; Region: Rmf; COG3130 1093787005796 potential frameshift: common BLAST hit: gi|218890752|ref|YP_002439616.1| 23S rRNA m(2)G2445 methyltransferase 1093787005797 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1093787005798 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1093787005799 hypothetical protein; Provisional; Region: PRK11702 1093787005800 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1093787005801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787005802 active site 1093787005803 phosphorylation site [posttranslational modification] 1093787005804 intermolecular recognition site; other site 1093787005805 dimerization interface [polypeptide binding]; other site 1093787005806 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787005807 DNA binding residues [nucleotide binding] 1093787005808 dimerization interface [polypeptide binding]; other site 1093787005809 PAS domain; Region: PAS_9; pfam13426 1093787005810 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787005811 dimer interface [polypeptide binding]; other site 1093787005812 phosphorylation site [posttranslational modification] 1093787005813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787005814 ATP binding site [chemical binding]; other site 1093787005815 Mg2+ binding site [ion binding]; other site 1093787005816 G-X-G motif; other site 1093787005817 Response regulator receiver domain; Region: Response_reg; pfam00072 1093787005818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787005819 active site 1093787005820 phosphorylation site [posttranslational modification] 1093787005821 intermolecular recognition site; other site 1093787005822 dimerization interface [polypeptide binding]; other site 1093787005823 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1093787005824 putative binding surface; other site 1093787005825 active site 1093787005826 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 1093787005827 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1093787005828 Zn2+ binding site [ion binding]; other site 1093787005829 Mg2+ binding site [ion binding]; other site 1093787005830 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1093787005831 Predicted membrane protein [Function unknown]; Region: COG5393 1093787005832 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1093787005833 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1093787005834 outer membrane porin, OprD family; Region: OprD; pfam03573 1093787005835 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1093787005836 Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576 1093787005837 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1093787005838 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1093787005839 putative C-terminal domain interface [polypeptide binding]; other site 1093787005840 putative GSH binding site (G-site) [chemical binding]; other site 1093787005841 putative dimer interface [polypeptide binding]; other site 1093787005842 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 1093787005843 putative N-terminal domain interface [polypeptide binding]; other site 1093787005844 putative dimer interface [polypeptide binding]; other site 1093787005845 putative substrate binding pocket (H-site) [chemical binding]; other site 1093787005846 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787005847 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787005848 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1093787005849 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1093787005850 Cytochrome c; Region: Cytochrom_C; pfam00034 1093787005851 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1093787005852 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1093787005853 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1093787005854 GTP binding site; other site 1093787005855 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1093787005856 MPT binding site; other site 1093787005857 trimer interface [polypeptide binding]; other site 1093787005858 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1093787005859 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1093787005860 dimer interface [polypeptide binding]; other site 1093787005861 putative functional site; other site 1093787005862 putative MPT binding site; other site 1093787005863 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1093787005864 Helix-turn-helix domain; Region: HTH_18; pfam12833 1093787005865 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787005866 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1093787005867 FAD binding domain; Region: FAD_binding_4; pfam01565 1093787005868 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1093787005869 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1093787005870 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 1093787005871 putative N- and C-terminal domain interface [polypeptide binding]; other site 1093787005872 putative active site [active] 1093787005873 MgATP binding site [chemical binding]; other site 1093787005874 catalytic site [active] 1093787005875 metal binding site [ion binding]; metal-binding site 1093787005876 putative carbohydrate binding site [chemical binding]; other site 1093787005877 lipid kinase; Reviewed; Region: PRK13054 1093787005878 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1093787005879 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1093787005880 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1093787005881 MOSC domain; Region: MOSC; pfam03473 1093787005882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1093787005883 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1093787005884 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1093787005885 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1093787005886 catalytic residue [active] 1093787005887 ABC transporter ATPase component; Reviewed; Region: PRK11147 1093787005888 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1093787005889 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1093787005890 ABC transporter; Region: ABC_tran_2; pfam12848 1093787005891 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1093787005892 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1093787005893 Ligand Binding Site [chemical binding]; other site 1093787005894 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1093787005895 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1093787005896 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1093787005897 substrate binding site [chemical binding]; other site 1093787005898 oxyanion hole (OAH) forming residues; other site 1093787005899 trimer interface [polypeptide binding]; other site 1093787005900 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1093787005901 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1093787005902 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1093787005903 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1093787005904 dimer interface [polypeptide binding]; other site 1093787005905 active site 1093787005906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4728 1093787005907 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1093787005908 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1093787005909 active site 1093787005910 interdomain interaction site; other site 1093787005911 putative metal-binding site [ion binding]; other site 1093787005912 nucleotide binding site [chemical binding]; other site 1093787005913 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1093787005914 domain I; other site 1093787005915 DNA binding groove [nucleotide binding] 1093787005916 phosphate binding site [ion binding]; other site 1093787005917 domain II; other site 1093787005918 domain III; other site 1093787005919 nucleotide binding site [chemical binding]; other site 1093787005920 catalytic site [active] 1093787005921 domain IV; other site 1093787005922 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1093787005923 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1093787005924 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1093787005925 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1093787005926 SOS-response cell division inhibitor, blocks FtsZ ring formation [Cell division and chromosome partitioning]; Region: SulA; COG5404 1093787005927 LexA repressor; Validated; Region: PRK00215 1093787005928 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1093787005929 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1093787005930 Catalytic site [active] 1093787005931 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787005932 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787005933 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1093787005934 beta-hexosaminidase; Provisional; Region: PRK05337 1093787005935 5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136 1093787005936 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 1093787005937 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1093787005938 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1093787005939 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1093787005940 ATP binding site [chemical binding]; other site 1093787005941 putative Mg++ binding site [ion binding]; other site 1093787005942 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1093787005943 nucleotide binding region [chemical binding]; other site 1093787005944 ATP-binding site [chemical binding]; other site 1093787005945 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1093787005946 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1093787005947 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1093787005948 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1093787005949 potential frameshift: common BLAST hit: gi|15598196|ref|NP_251690.1| aromatic amino acid transporter AroP1 1093787005950 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 1093787005951 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1093787005952 E3 interaction surface; other site 1093787005953 lipoyl attachment site [posttranslational modification]; other site 1093787005954 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 1093787005955 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 1093787005956 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 1093787005957 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 1093787005958 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 1093787005959 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 1093787005960 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 1093787005961 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1093787005962 catalytic loop [active] 1093787005963 iron binding site [ion binding]; other site 1093787005964 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 1093787005965 FAD binding pocket [chemical binding]; other site 1093787005966 FAD binding motif [chemical binding]; other site 1093787005967 phosphate binding motif [ion binding]; other site 1093787005968 beta-alpha-beta structure motif; other site 1093787005969 NAD binding pocket [chemical binding]; other site 1093787005970 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1093787005971 ApbE family; Region: ApbE; pfam02424 1093787005972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 1093787005973 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1093787005974 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1093787005975 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1093787005976 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1093787005977 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1093787005978 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 1093787005979 active site 1093787005980 catalytic site [active] 1093787005981 metal binding site [ion binding]; metal-binding site 1093787005982 PilZ domain; Region: PilZ; pfam07238 1093787005983 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1093787005984 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1093787005985 FtsX-like permease family; Region: FtsX; pfam02687 1093787005986 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1093787005987 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1093787005988 Walker A/P-loop; other site 1093787005989 ATP binding site [chemical binding]; other site 1093787005990 Q-loop/lid; other site 1093787005991 ABC transporter signature motif; other site 1093787005992 Walker B; other site 1093787005993 D-loop; other site 1093787005994 H-loop/switch region; other site 1093787005995 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1093787005996 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1093787005997 FtsX-like permease family; Region: FtsX; pfam02687 1093787005998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 1093787005999 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1093787006000 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1093787006001 Competence protein; Region: Competence; pfam03772 1093787006002 Competence protein; Region: Competence; cl00471 1093787006003 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1093787006004 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1093787006005 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1093787006006 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1093787006007 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1093787006008 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1093787006009 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1093787006010 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1093787006011 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1093787006012 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1093787006013 Ligand binding site; other site 1093787006014 oligomer interface; other site 1093787006015 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1093787006016 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1093787006017 active site 1093787006018 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1093787006019 FAD binding domain; Region: FAD_binding_4; pfam01565 1093787006020 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1093787006021 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1093787006022 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1093787006023 homodimer interface [polypeptide binding]; other site 1093787006024 oligonucleotide binding site [chemical binding]; other site 1093787006025 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1093787006026 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1093787006027 RNA binding surface [nucleotide binding]; other site 1093787006028 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1093787006029 active site 1093787006030 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1093787006031 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1093787006032 motif II; other site 1093787006033 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1093787006034 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1093787006035 tandem repeat interface [polypeptide binding]; other site 1093787006036 oligomer interface [polypeptide binding]; other site 1093787006037 active site residues [active] 1093787006038 Maf-like protein; Region: Maf; pfam02545 1093787006039 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1093787006040 active site 1093787006041 dimer interface [polypeptide binding]; other site 1093787006042 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1093787006043 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1093787006044 putative phosphate acyltransferase; Provisional; Region: PRK05331 1093787006045 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1093787006046 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1093787006047 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1093787006048 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1093787006049 NAD(P) binding site [chemical binding]; other site 1093787006050 homotetramer interface [polypeptide binding]; other site 1093787006051 homodimer interface [polypeptide binding]; other site 1093787006052 active site 1093787006053 acyl carrier protein; Provisional; Region: acpP; PRK00982 1093787006054 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1093787006055 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1093787006056 dimer interface [polypeptide binding]; other site 1093787006057 active site 1093787006058 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1093787006059 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1093787006060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787006061 catalytic residue [active] 1093787006062 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1093787006063 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1093787006064 dimerization interface [polypeptide binding]; other site 1093787006065 thymidylate kinase; Validated; Region: tmk; PRK00698 1093787006066 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1093787006067 TMP-binding site; other site 1093787006068 ATP-binding site [chemical binding]; other site 1093787006069 DNA polymerase III subunit delta'; Validated; Region: PRK05707 1093787006070 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1093787006071 Tfp pilus assembly protein PilZ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilZ; COG3215 1093787006072 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1093787006073 active site 1093787006074 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1093787006075 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1093787006076 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1093787006077 catalytic residue [active] 1093787006078 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787006079 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787006080 WHG domain; Region: WHG; pfam13305 1093787006081 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1093787006082 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1093787006083 FeS/SAM binding site; other site 1093787006084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 1093787006085 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 1093787006086 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1093787006087 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1093787006088 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1093787006089 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1093787006090 Ligand binding site [chemical binding]; other site 1093787006091 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1093787006092 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1093787006093 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1093787006094 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 1093787006095 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 1093787006096 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 1093787006097 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 1093787006098 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1093787006099 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1093787006100 nucleophilic elbow; other site 1093787006101 catalytic triad; other site 1093787006102 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1093787006103 active site 1093787006104 SAM binding site [chemical binding]; other site 1093787006105 homodimer interface [polypeptide binding]; other site 1093787006106 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1093787006107 Predicted integral membrane protein [Function unknown]; Region: COG5446 1093787006108 Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489 1093787006109 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 1093787006110 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1093787006111 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1093787006112 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1093787006113 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1093787006114 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1093787006115 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1093787006116 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1093787006117 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 1093787006118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787006119 Walker A motif; other site 1093787006120 ATP binding site [chemical binding]; other site 1093787006121 Walker B motif; other site 1093787006122 arginine finger; other site 1093787006123 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 1093787006124 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1093787006125 metal ion-dependent adhesion site (MIDAS); other site 1093787006126 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1093787006127 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1093787006128 dimer interface [polypeptide binding]; other site 1093787006129 active site 1093787006130 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1093787006131 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1093787006132 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 1093787006133 PA/protease or protease-like domain interface [polypeptide binding]; other site 1093787006134 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1093787006135 active site 1093787006136 metal binding site [ion binding]; metal-binding site 1093787006137 xanthine permease; Region: pbuX; TIGR03173 1093787006138 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1093787006139 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1093787006140 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1093787006141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787006142 putative substrate translocation pore; other site 1093787006143 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1093787006144 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1093787006145 FMN binding site [chemical binding]; other site 1093787006146 active site 1093787006147 substrate binding site [chemical binding]; other site 1093787006148 catalytic residue [active] 1093787006149 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787006150 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787006151 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787006152 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787006153 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787006154 dimerization interface [polypeptide binding]; other site 1093787006155 LysE type translocator; Region: LysE; cl00565 1093787006156 Serine hydrolase; Region: Ser_hydrolase; cl17834 1093787006157 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1093787006158 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1093787006159 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1093787006160 Walker A/P-loop; other site 1093787006161 ATP binding site [chemical binding]; other site 1093787006162 Q-loop/lid; other site 1093787006163 ABC transporter signature motif; other site 1093787006164 Walker B; other site 1093787006165 D-loop; other site 1093787006166 H-loop/switch region; other site 1093787006167 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1093787006168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787006169 dimer interface [polypeptide binding]; other site 1093787006170 conserved gate region; other site 1093787006171 putative PBP binding loops; other site 1093787006172 ABC-ATPase subunit interface; other site 1093787006173 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1093787006174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787006175 dimer interface [polypeptide binding]; other site 1093787006176 conserved gate region; other site 1093787006177 putative PBP binding loops; other site 1093787006178 ABC-ATPase subunit interface; other site 1093787006179 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1093787006180 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787006181 substrate binding pocket [chemical binding]; other site 1093787006182 membrane-bound complex binding site; other site 1093787006183 hinge residues; other site 1093787006184 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1093787006185 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1093787006186 metal binding site [ion binding]; metal-binding site 1093787006187 putative dimer interface [polypeptide binding]; other site 1093787006188 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787006189 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787006190 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1093787006191 dimerization interface [polypeptide binding]; other site 1093787006192 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787006193 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1093787006194 dimerization interface [polypeptide binding]; other site 1093787006195 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787006196 dimer interface [polypeptide binding]; other site 1093787006197 putative CheW interface [polypeptide binding]; other site 1093787006198 short chain dehydrogenase; Provisional; Region: PRK12744 1093787006199 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787006200 NAD(P) binding site [chemical binding]; other site 1093787006201 active site 1093787006202 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1093787006203 Helix-turn-helix domain; Region: HTH_18; pfam12833 1093787006204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787006205 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1093787006206 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1093787006207 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1093787006208 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1093787006209 ABC-ATPase subunit interface; other site 1093787006210 dimer interface [polypeptide binding]; other site 1093787006211 putative PBP binding regions; other site 1093787006212 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1093787006213 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1093787006214 putative ligand binding residues [chemical binding]; other site 1093787006215 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1093787006216 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787006217 Walker A/P-loop; other site 1093787006218 ATP binding site [chemical binding]; other site 1093787006219 Q-loop/lid; other site 1093787006220 ABC transporter signature motif; other site 1093787006221 Walker B; other site 1093787006222 H-loop/switch region; other site 1093787006223 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1093787006224 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787006225 N-terminal plug; other site 1093787006226 ligand-binding site [chemical binding]; other site 1093787006227 Predicted membrane protein [Function unknown]; Region: COG1971 1093787006228 Domain of unknown function DUF; Region: DUF204; pfam02659 1093787006229 Domain of unknown function DUF; Region: DUF204; pfam02659 1093787006230 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1093787006231 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1093787006232 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1093787006233 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1093787006234 active site 1093787006235 putative homodimer interface [polypeptide binding]; other site 1093787006236 SAM binding site [chemical binding]; other site 1093787006237 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1093787006238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787006239 S-adenosylmethionine binding site [chemical binding]; other site 1093787006240 precorrin-3B synthase; Region: CobG; TIGR02435 1093787006241 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1093787006242 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1093787006243 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1093787006244 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1093787006245 homodimer interface [polypeptide binding]; other site 1093787006246 active site 1093787006247 SAM binding site [chemical binding]; other site 1093787006248 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 1093787006249 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1093787006250 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1093787006251 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1093787006252 active site 1093787006253 SAM binding site [chemical binding]; other site 1093787006254 homodimer interface [polypeptide binding]; other site 1093787006255 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787006256 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1093787006257 substrate binding pocket [chemical binding]; other site 1093787006258 membrane-bound complex binding site; other site 1093787006259 hinge residues; other site 1093787006260 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1093787006261 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1093787006262 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1093787006263 ligand binding site [chemical binding]; other site 1093787006264 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1093787006265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787006266 active site 1093787006267 phosphorylation site [posttranslational modification] 1093787006268 intermolecular recognition site; other site 1093787006269 dimerization interface [polypeptide binding]; other site 1093787006270 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787006271 DNA binding residues [nucleotide binding] 1093787006272 dimerization interface [polypeptide binding]; other site 1093787006273 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1093787006274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787006275 DNA-binding site [nucleotide binding]; DNA binding site 1093787006276 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1093787006277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787006278 homodimer interface [polypeptide binding]; other site 1093787006279 catalytic residue [active] 1093787006280 RNA polymerase sigma factor; Provisional; Region: PRK12513 1093787006281 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1093787006282 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1093787006283 DNA binding residues [nucleotide binding] 1093787006284 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1093787006285 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1093787006286 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1093787006287 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1093787006288 acyl-activating enzyme (AAE) consensus motif; other site 1093787006289 acyl-activating enzyme (AAE) consensus motif; other site 1093787006290 putative AMP binding site [chemical binding]; other site 1093787006291 putative active site [active] 1093787006292 putative CoA binding site [chemical binding]; other site 1093787006293 short chain dehydrogenase; Provisional; Region: PRK08278 1093787006294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787006295 NAD(P) binding site [chemical binding]; other site 1093787006296 active site 1093787006297 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1093787006298 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1093787006299 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1093787006300 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1093787006301 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1093787006302 carboxyltransferase (CT) interaction site; other site 1093787006303 biotinylation site [posttranslational modification]; other site 1093787006304 enoyl-CoA hydratase; Provisional; Region: PRK05995 1093787006305 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1093787006306 substrate binding site [chemical binding]; other site 1093787006307 oxyanion hole (OAH) forming residues; other site 1093787006308 trimer interface [polypeptide binding]; other site 1093787006309 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1093787006310 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787006311 active site 1093787006312 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1093787006313 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1093787006314 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1093787006315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787006316 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1093787006317 NAD(P) binding site [chemical binding]; other site 1093787006318 active site 1093787006319 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1093787006320 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787006321 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787006322 CAAX protease self-immunity; Region: Abi; pfam02517 1093787006323 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 1093787006324 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1093787006325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787006326 ATP binding site [chemical binding]; other site 1093787006327 Mg2+ binding site [ion binding]; other site 1093787006328 G-X-G motif; other site 1093787006329 Response regulator receiver domain; Region: Response_reg; pfam00072 1093787006330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787006331 active site 1093787006332 phosphorylation site [posttranslational modification] 1093787006333 intermolecular recognition site; other site 1093787006334 dimerization interface [polypeptide binding]; other site 1093787006335 Predicted membrane protein [Function unknown]; Region: COG4125 1093787006336 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1093787006337 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1093787006338 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787006339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787006340 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1093787006341 dimerization interface [polypeptide binding]; other site 1093787006342 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 1093787006343 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787006344 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787006345 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1093787006346 putative effector binding pocket; other site 1093787006347 putative dimerization interface [polypeptide binding]; other site 1093787006348 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1093787006349 active site 1093787006350 dimer interface [polypeptide binding]; other site 1093787006351 MoxR-like ATPases [General function prediction only]; Region: COG0714 1093787006352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787006353 Walker A motif; other site 1093787006354 ATP binding site [chemical binding]; other site 1093787006355 Walker B motif; other site 1093787006356 arginine finger; other site 1093787006357 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1093787006358 Protein of unknown function DUF58; Region: DUF58; pfam01882 1093787006359 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 1093787006360 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1093787006361 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1093787006362 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1093787006363 Uncharacterized conserved protein [Function unknown]; Region: COG5607 1093787006364 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1093787006365 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1093787006366 active site 1093787006367 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1093787006368 active site 2 [active] 1093787006369 active site 1 [active] 1093787006370 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787006371 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787006372 metal binding site [ion binding]; metal-binding site 1093787006373 active site 1093787006374 I-site; other site 1093787006375 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1093787006376 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1093787006377 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787006378 dimerization interface [polypeptide binding]; other site 1093787006379 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1093787006380 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787006381 dimer interface [polypeptide binding]; other site 1093787006382 putative CheW interface [polypeptide binding]; other site 1093787006383 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1093787006384 active site 1093787006385 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623 1093787006386 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787006387 substrate binding pocket [chemical binding]; other site 1093787006388 membrane-bound complex binding site; other site 1093787006389 hinge residues; other site 1093787006390 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1093787006391 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1093787006392 catalytic residue [active] 1093787006393 Predicted membrane protein [Function unknown]; Region: COG2259 1093787006394 lipase chaperone; Provisional; Region: PRK01294 1093787006395 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 1093787006396 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1093787006397 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1093787006398 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 1093787006399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1093787006400 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1093787006401 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1093787006402 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1093787006403 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1093787006404 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1093787006405 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1093787006406 Walker A/P-loop; other site 1093787006407 ATP binding site [chemical binding]; other site 1093787006408 Q-loop/lid; other site 1093787006409 ABC transporter signature motif; other site 1093787006410 Walker B; other site 1093787006411 D-loop; other site 1093787006412 H-loop/switch region; other site 1093787006413 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1093787006414 active site 1093787006415 catalytic triad [active] 1093787006416 oxyanion hole [active] 1093787006417 switch loop; other site 1093787006418 L,D-transpeptidase; Provisional; Region: PRK10260 1093787006419 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1093787006420 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1093787006421 Protein of unknown function (DUF3359); Region: DUF3359; pfam11839 1093787006422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 1093787006423 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 1093787006424 elongation factor P; Validated; Region: PRK00529 1093787006425 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1093787006426 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1093787006427 RNA binding site [nucleotide binding]; other site 1093787006428 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1093787006429 RNA binding site [nucleotide binding]; other site 1093787006430 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1093787006431 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1093787006432 MarR family; Region: MarR; pfam01047 1093787006433 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787006434 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787006435 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1093787006436 putative effector binding pocket; other site 1093787006437 dimerization interface [polypeptide binding]; other site 1093787006438 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1093787006439 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787006440 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787006441 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787006442 dimerization interface [polypeptide binding]; other site 1093787006443 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1093787006444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1093787006445 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1093787006446 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1093787006447 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 1093787006448 enoyl-CoA hydratase; Provisional; Region: PRK06563 1093787006449 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1093787006450 substrate binding site [chemical binding]; other site 1093787006451 oxyanion hole (OAH) forming residues; other site 1093787006452 trimer interface [polypeptide binding]; other site 1093787006453 helicase 45; Provisional; Region: PTZ00424 1093787006454 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1093787006455 ATP binding site [chemical binding]; other site 1093787006456 Mg++ binding site [ion binding]; other site 1093787006457 motif III; other site 1093787006458 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1093787006459 nucleotide binding region [chemical binding]; other site 1093787006460 ATP-binding site [chemical binding]; other site 1093787006461 DbpA RNA binding domain; Region: DbpA; pfam03880 1093787006462 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1093787006463 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1093787006464 putative active site [active] 1093787006465 metal binding site [ion binding]; metal-binding site 1093787006466 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787006467 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787006468 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1093787006469 putative effector binding pocket; other site 1093787006470 dimerization interface [polypeptide binding]; other site 1093787006471 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1093787006472 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1093787006473 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787006474 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787006475 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1093787006476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787006477 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787006478 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787006479 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1093787006480 putative substrate binding pocket [chemical binding]; other site 1093787006481 putative dimerization interface [polypeptide binding]; other site 1093787006482 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1093787006483 Ligand Binding Site [chemical binding]; other site 1093787006484 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 1093787006485 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1093787006486 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 1093787006487 putative active site [active] 1093787006488 Zn binding site [ion binding]; other site 1093787006489 heat shock protein HtpX; Provisional; Region: PRK05457 1093787006490 aminotransferase AlaT; Validated; Region: PRK09265 1093787006491 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1093787006492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787006493 homodimer interface [polypeptide binding]; other site 1093787006494 catalytic residue [active] 1093787006495 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1093787006496 SelR domain; Region: SelR; pfam01641 1093787006497 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1093787006498 catalytic residues [active] 1093787006499 dimer interface [polypeptide binding]; other site 1093787006500 MarR family; Region: MarR_2; cl17246 1093787006501 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1093787006502 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1093787006503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787006504 ATP binding site [chemical binding]; other site 1093787006505 Mg2+ binding site [ion binding]; other site 1093787006506 G-X-G motif; other site 1093787006507 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1093787006508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787006509 active site 1093787006510 phosphorylation site [posttranslational modification] 1093787006511 intermolecular recognition site; other site 1093787006512 dimerization interface [polypeptide binding]; other site 1093787006513 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1093787006514 Protein of unknown function (DUF815); Region: DUF815; pfam05673 1093787006515 Walker A motif; other site 1093787006516 ATP binding site [chemical binding]; other site 1093787006517 Walker B motif; other site 1093787006518 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1093787006519 GAF domain; Region: GAF_2; pfam13185 1093787006520 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1093787006521 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1093787006522 C-terminal domain interface [polypeptide binding]; other site 1093787006523 GSH binding site (G-site) [chemical binding]; other site 1093787006524 dimer interface [polypeptide binding]; other site 1093787006525 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1093787006526 N-terminal domain interface [polypeptide binding]; other site 1093787006527 dimer interface [polypeptide binding]; other site 1093787006528 substrate binding pocket (H-site) [chemical binding]; other site 1093787006529 Killing trait; Region: RebB; pfam11747 1093787006530 Killing trait; Region: RebB; pfam11747 1093787006531 Phenylalanyl-tRNA synthetase alpha subunit [Translation, ribosomal structure and biogenesis]; Region: PheS; COG0016 1093787006532 Killing trait; Region: RebB; pfam11747 1093787006533 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1093787006534 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1093787006535 DNA binding residues [nucleotide binding] 1093787006536 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1093787006537 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1093787006538 ligand binding site [chemical binding]; other site 1093787006539 flexible hinge region; other site 1093787006540 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1093787006541 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1093787006542 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1093787006543 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1093787006544 active site 1093787006545 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1093787006546 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1093787006547 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1093787006548 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1093787006549 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1093787006550 putative C-terminal domain interface [polypeptide binding]; other site 1093787006551 putative GSH binding site (G-site) [chemical binding]; other site 1093787006552 putative dimer interface [polypeptide binding]; other site 1093787006553 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1093787006554 putative N-terminal domain interface [polypeptide binding]; other site 1093787006555 putative dimer interface [polypeptide binding]; other site 1093787006556 putative substrate binding pocket (H-site) [chemical binding]; other site 1093787006557 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1093787006558 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787006559 Walker A/P-loop; other site 1093787006560 ATP binding site [chemical binding]; other site 1093787006561 Q-loop/lid; other site 1093787006562 ABC transporter signature motif; other site 1093787006563 Walker B; other site 1093787006564 D-loop; other site 1093787006565 H-loop/switch region; other site 1093787006566 inner membrane transport permease; Provisional; Region: PRK15066 1093787006567 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1093787006568 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1093787006569 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787006570 dimerization interface [polypeptide binding]; other site 1093787006571 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787006572 dimer interface [polypeptide binding]; other site 1093787006573 phosphorylation site [posttranslational modification] 1093787006574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787006575 ATP binding site [chemical binding]; other site 1093787006576 Mg2+ binding site [ion binding]; other site 1093787006577 G-X-G motif; other site 1093787006578 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1093787006579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787006580 active site 1093787006581 phosphorylation site [posttranslational modification] 1093787006582 intermolecular recognition site; other site 1093787006583 dimerization interface [polypeptide binding]; other site 1093787006584 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787006585 DNA binding site [nucleotide binding] 1093787006586 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 1093787006587 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1093787006588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1093787006589 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1093787006590 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1093787006591 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 1093787006592 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1093787006593 Zn2+ binding site [ion binding]; other site 1093787006594 Mg2+ binding site [ion binding]; other site 1093787006595 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1093787006596 transcriptional regulator protein; Region: phnR; TIGR03337 1093787006597 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787006598 DNA-binding site [nucleotide binding]; DNA binding site 1093787006599 UTRA domain; Region: UTRA; pfam07702 1093787006600 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1093787006601 active site 1093787006602 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 1093787006603 PilZ domain; Region: PilZ; pfam07238 1093787006604 Response regulator receiver domain; Region: Response_reg; pfam00072 1093787006605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787006606 active site 1093787006607 phosphorylation site [posttranslational modification] 1093787006608 intermolecular recognition site; other site 1093787006609 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1093787006610 dimerization interface [polypeptide binding]; other site 1093787006611 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1093787006612 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1093787006613 anti sigma factor interaction site; other site 1093787006614 regulatory phosphorylation site [posttranslational modification]; other site 1093787006615 transaldolase-like protein; Provisional; Region: PTZ00411 1093787006616 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1093787006617 active site 1093787006618 dimer interface [polypeptide binding]; other site 1093787006619 catalytic residue [active] 1093787006620 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1093787006621 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1093787006622 FMN binding site [chemical binding]; other site 1093787006623 active site 1093787006624 catalytic residues [active] 1093787006625 substrate binding site [chemical binding]; other site 1093787006626 Isochorismatase family; Region: Isochorismatase; pfam00857 1093787006627 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1093787006628 catalytic triad [active] 1093787006629 conserved cis-peptide bond; other site 1093787006630 drug efflux system protein MdtG; Provisional; Region: PRK09874 1093787006631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787006632 putative substrate translocation pore; other site 1093787006633 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1093787006634 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787006635 DNA-binding site [nucleotide binding]; DNA binding site 1093787006636 FCD domain; Region: FCD; pfam07729 1093787006637 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1093787006638 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1093787006639 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787006640 dimer interface [polypeptide binding]; other site 1093787006641 putative CheW interface [polypeptide binding]; other site 1093787006642 glutamate carboxypeptidase; Reviewed; Region: PRK06133 1093787006643 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1093787006644 metal binding site [ion binding]; metal-binding site 1093787006645 dimer interface [polypeptide binding]; other site 1093787006646 GAF domain; Region: GAF_2; pfam13185 1093787006647 Predicted transcriptional regulator [Transcription]; Region: COG3655 1093787006648 salt bridge; other site 1093787006649 non-specific DNA binding site [nucleotide binding]; other site 1093787006650 sequence-specific DNA binding site [nucleotide binding]; other site 1093787006651 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 1093787006652 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_3; pfam13582 1093787006653 active site 1093787006654 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1093787006655 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1093787006656 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1093787006657 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1093787006658 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1093787006659 non-specific DNA binding site [nucleotide binding]; other site 1093787006660 salt bridge; other site 1093787006661 sequence-specific DNA binding site [nucleotide binding]; other site 1093787006662 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1093787006663 putative active site [active] 1093787006664 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1093787006665 binding surface 1093787006666 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1093787006667 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1093787006668 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1093787006669 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1093787006670 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1093787006671 GAF domain; Region: GAF; pfam01590 1093787006672 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787006673 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787006674 metal binding site [ion binding]; metal-binding site 1093787006675 active site 1093787006676 I-site; other site 1093787006677 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1093787006678 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 1093787006679 nudix motif; other site 1093787006680 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1093787006681 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1093787006682 substrate binding site [chemical binding]; other site 1093787006683 oxyanion hole (OAH) forming residues; other site 1093787006684 trimer interface [polypeptide binding]; other site 1093787006685 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1093787006686 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787006687 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787006688 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1093787006689 Serine hydrolase; Region: Ser_hydrolase; cl17834 1093787006690 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1093787006691 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1093787006692 outer membrane porin, OprD family; Region: OprD; pfam03573 1093787006693 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787006694 Predicted membrane protein [Function unknown]; Region: COG4125 1093787006695 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1093787006696 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1093787006697 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 1093787006698 Serine protease inhibitor ecotin [General function prediction only]; Region: Eco; COG4574 1093787006699 secondary substrate binding site; other site 1093787006700 primary substrate binding site; other site 1093787006701 inhibition loop; other site 1093787006702 dimerization interface [polypeptide binding]; other site 1093787006703 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 1093787006704 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1093787006705 Predicted membrane protein [Function unknown]; Region: COG1238 1093787006706 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1093787006707 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1093787006708 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1093787006709 DNA-specific endonuclease I; Provisional; Region: PRK15137 1093787006710 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1093787006711 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1093787006712 active site 1093787006713 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1093787006714 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1093787006715 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1093787006716 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1093787006717 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1093787006718 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1093787006719 active site 1093787006720 dimer interface [polypeptide binding]; other site 1093787006721 motif 1; other site 1093787006722 motif 2; other site 1093787006723 motif 3; other site 1093787006724 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1093787006725 anticodon binding site; other site 1093787006726 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1093787006727 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1093787006728 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1093787006729 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1093787006730 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1093787006731 23S rRNA binding site [nucleotide binding]; other site 1093787006732 L21 binding site [polypeptide binding]; other site 1093787006733 L13 binding site [polypeptide binding]; other site 1093787006734 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1093787006735 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1093787006736 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1093787006737 dimer interface [polypeptide binding]; other site 1093787006738 motif 1; other site 1093787006739 active site 1093787006740 motif 2; other site 1093787006741 motif 3; other site 1093787006742 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1093787006743 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1093787006744 putative tRNA-binding site [nucleotide binding]; other site 1093787006745 B3/4 domain; Region: B3_4; pfam03483 1093787006746 tRNA synthetase B5 domain; Region: B5; smart00874 1093787006747 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1093787006748 dimer interface [polypeptide binding]; other site 1093787006749 motif 1; other site 1093787006750 motif 3; other site 1093787006751 motif 2; other site 1093787006752 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1093787006753 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1093787006754 IHF dimer interface [polypeptide binding]; other site 1093787006755 IHF - DNA interface [nucleotide binding]; other site 1093787006756 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 1093787006757 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1093787006758 DNA binding residues [nucleotide binding] 1093787006759 potential frameshift: common BLAST hit: gi|170719224|ref|YP_001746912.1| transposase IS66 1093787006760 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1093787006761 Transposase; Region: HTH_Tnp_1; pfam01527 1093787006762 HTH-like domain; Region: HTH_21; pfam13276 1093787006763 Integrase core domain; Region: rve; pfam00665 1093787006764 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1093787006765 Integrase core domain; Region: rve_3; pfam13683 1093787006766 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1093787006767 Protein of unknown function (DUF4427); Region: DUF4427; pfam14468 1093787006768 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1093787006769 active site 1093787006770 HTH-like domain; Region: HTH_21; pfam13276 1093787006771 Integrase core domain; Region: rve; pfam00665 1093787006772 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1093787006773 Integrase core domain; Region: rve_3; pfam13683 1093787006774 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1093787006775 Transposase; Region: HTH_Tnp_1; pfam01527 1093787006776 potential frameshift: common BLAST hit: gi|66043887|ref|YP_233728.1| Outer membrane autotransporter barrel 1093787006777 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1093787006778 sequence-specific DNA binding site [nucleotide binding]; other site 1093787006779 salt bridge; other site 1093787006780 carbon storage regulator; Provisional; Region: PRK01712 1093787006781 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 1093787006782 phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299 1093787006783 DNA-sulfur modification-associated; Region: DndB; cl17621 1093787006784 DGQHR domain; Region: DGQHR; TIGR03187 1093787006785 putative sulfurtransferase DndC; Region: DNA_S_dndC; TIGR03183 1093787006786 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 1093787006787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787006788 Walker A/P-loop; other site 1093787006789 ATP binding site [chemical binding]; other site 1093787006790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787006791 ABC transporter signature motif; other site 1093787006792 Walker B; other site 1093787006793 D-loop; other site 1093787006794 H-loop/switch region; other site 1093787006795 Domain of unknown function (DUF1832); Region: DUF1832; cl07463 1093787006796 integrase; Provisional; Region: PRK09692 1093787006797 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1093787006798 active site 1093787006799 Int/Topo IB signature motif; other site 1093787006800 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1093787006801 Part of AAA domain; Region: AAA_19; pfam13245 1093787006802 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1093787006803 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1093787006804 homodimer interface [polypeptide binding]; other site 1093787006805 chemical substrate binding site [chemical binding]; other site 1093787006806 oligomer interface [polypeptide binding]; other site 1093787006807 metal binding site [ion binding]; metal-binding site 1093787006808 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 1093787006809 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1093787006810 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1093787006811 active site 1093787006812 ATP binding site [chemical binding]; other site 1093787006813 substrate binding site [chemical binding]; other site 1093787006814 activation loop (A-loop); other site 1093787006815 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 1093787006816 AAA domain; Region: AAA_11; pfam13086 1093787006817 Part of AAA domain; Region: AAA_19; pfam13245 1093787006818 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1093787006819 AAA domain; Region: AAA_12; pfam13087 1093787006820 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1093787006821 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1093787006822 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1093787006823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787006824 Walker A motif; other site 1093787006825 ATP binding site [chemical binding]; other site 1093787006826 Walker B motif; other site 1093787006827 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1093787006828 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1093787006829 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1093787006830 dimer interface [polypeptide binding]; other site 1093787006831 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1093787006832 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1093787006833 potential catalytic triad [active] 1093787006834 conserved cys residue [active] 1093787006835 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1093787006836 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1093787006837 DNA binding residues [nucleotide binding] 1093787006838 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1093787006839 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1093787006840 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1093787006841 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1093787006842 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 1093787006843 putative active site [active] 1093787006844 putative FMN binding site [chemical binding]; other site 1093787006845 putative substrate binding site [chemical binding]; other site 1093787006846 putative catalytic residue [active] 1093787006847 Ferredoxin [Energy production and conversion]; Region: COG1146 1093787006848 4Fe-4S binding domain; Region: Fer4; cl02805 1093787006849 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1093787006850 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1093787006851 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1093787006852 putative [Fe4-S4] binding site [ion binding]; other site 1093787006853 putative molybdopterin cofactor binding site [chemical binding]; other site 1093787006854 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1093787006855 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1093787006856 putative molybdopterin cofactor binding site; other site 1093787006857 Predicted transcriptional regulators [Transcription]; Region: COG1733 1093787006858 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1093787006859 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 1093787006860 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1093787006861 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1093787006862 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1093787006863 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1093787006864 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1093787006865 dimer interface [polypeptide binding]; other site 1093787006866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787006867 catalytic residue [active] 1093787006868 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1093787006869 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1093787006870 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787006871 Walker A motif; other site 1093787006872 ATP binding site [chemical binding]; other site 1093787006873 Walker B motif; other site 1093787006874 arginine finger; other site 1093787006875 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1093787006876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 1093787006877 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1093787006878 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787006879 Tse2 immunity protein Tsi2 and similar proteins; Region: Tsi2_like; cd11690 1093787006880 dimer interface [polypeptide binding]; other site 1093787006881 Transmembrane secretion effector; Region: MFS_3; pfam05977 1093787006882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787006883 putative substrate translocation pore; other site 1093787006884 outer membrane porin, OprD family; Region: OprD; pfam03573 1093787006885 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1093787006886 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1093787006887 active site 1093787006888 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1093787006889 Isochorismatase family; Region: Isochorismatase; pfam00857 1093787006890 catalytic triad [active] 1093787006891 dimer interface [polypeptide binding]; other site 1093787006892 conserved cis-peptide bond; other site 1093787006893 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 1093787006894 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787006895 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787006896 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787006897 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1093787006898 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1093787006899 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1093787006900 catalytic residues [active] 1093787006901 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1093787006902 Predicted transcriptional regulator [Transcription]; Region: COG1959 1093787006903 Transcriptional regulator; Region: Rrf2; pfam02082 1093787006904 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1093787006905 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1093787006906 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1093787006907 outer membrane receptor FepA; Provisional; Region: PRK13524 1093787006908 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787006909 N-terminal plug; other site 1093787006910 ligand-binding site [chemical binding]; other site 1093787006911 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1093787006912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787006913 phosphorylation site [posttranslational modification] 1093787006914 dimer interface [polypeptide binding]; other site 1093787006915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787006916 ATP binding site [chemical binding]; other site 1093787006917 Mg2+ binding site [ion binding]; other site 1093787006918 G-X-G motif; other site 1093787006919 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1093787006920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787006921 active site 1093787006922 phosphorylation site [posttranslational modification] 1093787006923 intermolecular recognition site; other site 1093787006924 dimerization interface [polypeptide binding]; other site 1093787006925 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787006926 DNA binding site [nucleotide binding] 1093787006927 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1093787006928 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1093787006929 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1093787006930 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1093787006931 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1093787006932 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1093787006933 RHS Repeat; Region: RHS_repeat; pfam05593 1093787006934 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1093787006935 RHS Repeat; Region: RHS_repeat; pfam05593 1093787006936 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1093787006937 RHS Repeat; Region: RHS_repeat; pfam05593 1093787006938 RHS Repeat; Region: RHS_repeat; cl11982 1093787006939 RHS protein; Region: RHS; pfam03527 1093787006940 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1093787006941 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1093787006942 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1093787006943 tetramer interface [polypeptide binding]; other site 1093787006944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787006945 catalytic residue [active] 1093787006946 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1093787006947 SnoaL-like domain; Region: SnoaL_2; pfam12680 1093787006948 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787006949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787006950 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1093787006951 putative effector binding pocket; other site 1093787006952 dimerization interface [polypeptide binding]; other site 1093787006953 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1093787006954 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1093787006955 NADP binding site [chemical binding]; other site 1093787006956 dimer interface [polypeptide binding]; other site 1093787006957 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1093787006958 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787006959 S-adenosylmethionine binding site [chemical binding]; other site 1093787006960 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1093787006961 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1093787006962 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1093787006963 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1093787006964 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1093787006965 Walker A motif; other site 1093787006966 ATP binding site [chemical binding]; other site 1093787006967 Walker B motif; other site 1093787006968 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1093787006969 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1093787006970 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1093787006971 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1093787006972 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1093787006973 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1093787006974 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 1093787006975 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1093787006976 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1093787006977 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1093787006978 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1093787006979 active site 1093787006980 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1093787006981 GAF domain; Region: GAF; pfam01590 1093787006982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787006983 Walker A motif; other site 1093787006984 ATP binding site [chemical binding]; other site 1093787006985 Walker B motif; other site 1093787006986 arginine finger; other site 1093787006987 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1093787006988 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1093787006989 heme-binding site [chemical binding]; other site 1093787006990 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1093787006991 FAD binding pocket [chemical binding]; other site 1093787006992 FAD binding motif [chemical binding]; other site 1093787006993 phosphate binding motif [ion binding]; other site 1093787006994 beta-alpha-beta structure motif; other site 1093787006995 NAD binding pocket [chemical binding]; other site 1093787006996 Heme binding pocket [chemical binding]; other site 1093787006997 NnrS protein; Region: NnrS; cl01258 1093787006998 hypothetical protein; Provisional; Region: PRK10318 1093787006999 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1093787007000 Predicted membrane protein [Function unknown]; Region: COG3212 1093787007001 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1093787007002 Predicted membrane protein [Function unknown]; Region: COG3212 1093787007003 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1093787007004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787007005 active site 1093787007006 phosphorylation site [posttranslational modification] 1093787007007 intermolecular recognition site; other site 1093787007008 dimerization interface [polypeptide binding]; other site 1093787007009 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787007010 DNA binding site [nucleotide binding] 1093787007011 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1093787007012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787007013 ATP binding site [chemical binding]; other site 1093787007014 Mg2+ binding site [ion binding]; other site 1093787007015 G-X-G motif; other site 1093787007016 Cache domain; Region: Cache_1; pfam02743 1093787007017 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787007018 dimerization interface [polypeptide binding]; other site 1093787007019 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1093787007020 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787007021 dimer interface [polypeptide binding]; other site 1093787007022 putative CheW interface [polypeptide binding]; other site 1093787007023 Predicted permease [General function prediction only]; Region: COG2056 1093787007024 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1093787007025 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1093787007026 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787007027 dimerization interface [polypeptide binding]; other site 1093787007028 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1093787007029 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787007030 dimer interface [polypeptide binding]; other site 1093787007031 putative CheW interface [polypeptide binding]; other site 1093787007032 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1093787007033 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1093787007034 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1093787007035 hypothetical protein; Reviewed; Region: PRK09588 1093787007036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787007037 S-adenosylmethionine binding site [chemical binding]; other site 1093787007038 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1093787007039 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1093787007040 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1093787007041 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1093787007042 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1093787007043 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1093787007044 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1093787007045 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1093787007046 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 1093787007047 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1093787007048 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1093787007049 4Fe-4S binding domain; Region: Fer4; pfam00037 1093787007050 4Fe-4S binding domain; Region: Fer4; pfam00037 1093787007051 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1093787007052 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1093787007053 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1093787007054 catalytic loop [active] 1093787007055 iron binding site [ion binding]; other site 1093787007056 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1093787007057 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1093787007058 [4Fe-4S] binding site [ion binding]; other site 1093787007059 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1093787007060 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1093787007061 SLBB domain; Region: SLBB; pfam10531 1093787007062 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1093787007063 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1093787007064 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1093787007065 putative dimer interface [polypeptide binding]; other site 1093787007066 [2Fe-2S] cluster binding site [ion binding]; other site 1093787007067 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1093787007068 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1093787007069 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1093787007070 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1093787007071 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1093787007072 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1093787007073 CoenzymeA binding site [chemical binding]; other site 1093787007074 subunit interaction site [polypeptide binding]; other site 1093787007075 PHB binding site; other site 1093787007076 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1093787007077 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1093787007078 tetramer interface [polypeptide binding]; other site 1093787007079 active site 1093787007080 Mg2+/Mn2+ binding site [ion binding]; other site 1093787007081 isocitrate lyase; Region: PLN02892 1093787007082 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1093787007083 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1093787007084 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1093787007085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787007086 Coenzyme A binding pocket [chemical binding]; other site 1093787007087 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1093787007088 Cupin domain; Region: Cupin_2; cl17218 1093787007089 adenylosuccinate lyase; Provisional; Region: PRK09285 1093787007090 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1093787007091 tetramer interface [polypeptide binding]; other site 1093787007092 active site 1093787007093 EamA-like transporter family; Region: EamA; pfam00892 1093787007094 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1093787007095 Uncharacterized protein involved in purine metabolism [General function prediction only]; Region: COG2915 1093787007096 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1093787007097 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1093787007098 Ligand Binding Site [chemical binding]; other site 1093787007099 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1093787007100 nudix motif; other site 1093787007101 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1093787007102 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 1093787007103 isocitrate dehydrogenase; Validated; Region: PRK07362 1093787007104 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1093787007105 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1093787007106 DNA-binding site [nucleotide binding]; DNA binding site 1093787007107 RNA-binding motif; other site 1093787007108 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1093787007109 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1093787007110 Clp amino terminal domain; Region: Clp_N; pfam02861 1093787007111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787007112 Walker A motif; other site 1093787007113 ATP binding site [chemical binding]; other site 1093787007114 Walker B motif; other site 1093787007115 arginine finger; other site 1093787007116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787007117 Walker A motif; other site 1093787007118 ATP binding site [chemical binding]; other site 1093787007119 Walker B motif; other site 1093787007120 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1093787007121 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1093787007122 rRNA binding site [nucleotide binding]; other site 1093787007123 predicted 30S ribosome binding site; other site 1093787007124 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 1093787007125 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1093787007126 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1093787007127 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1093787007128 thioredoxin reductase; Provisional; Region: PRK10262 1093787007129 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1093787007130 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1093787007131 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1093787007132 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1093787007133 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1093787007134 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1093787007135 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1093787007136 recombination factor protein RarA; Reviewed; Region: PRK13342 1093787007137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787007138 Walker A motif; other site 1093787007139 ATP binding site [chemical binding]; other site 1093787007140 Walker B motif; other site 1093787007141 arginine finger; other site 1093787007142 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1093787007143 seryl-tRNA synthetase; Provisional; Region: PRK05431 1093787007144 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1093787007145 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1093787007146 dimer interface [polypeptide binding]; other site 1093787007147 active site 1093787007148 motif 1; other site 1093787007149 motif 2; other site 1093787007150 motif 3; other site 1093787007151 siroheme synthase; Provisional; Region: cysG; PRK10637 1093787007152 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1093787007153 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1093787007154 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1093787007155 active site 1093787007156 SAM binding site [chemical binding]; other site 1093787007157 homodimer interface [polypeptide binding]; other site 1093787007158 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1093787007159 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1093787007160 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1093787007161 putative dimer interface [polypeptide binding]; other site 1093787007162 N-terminal domain interface [polypeptide binding]; other site 1093787007163 putative substrate binding pocket (H-site) [chemical binding]; other site 1093787007164 hypothetical protein; Validated; Region: PRK09071 1093787007165 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1093787007166 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1093787007167 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 1093787007168 DsrH like protein; Region: DsrH; cl17347 1093787007169 sulfur relay protein TusC; Validated; Region: PRK00211 1093787007170 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1093787007171 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1093787007172 YccA-like proteins; Region: YccA_like; cd10433 1093787007173 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1093787007174 active site residue [active] 1093787007175 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 1093787007176 active site residue [active] 1093787007177 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 1093787007178 active site residue [active] 1093787007179 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 1093787007180 active site residue [active] 1093787007181 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1093787007182 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787007183 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787007184 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1093787007185 dimerization interface [polypeptide binding]; other site 1093787007186 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1093787007187 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1093787007188 dimer interface [polypeptide binding]; other site 1093787007189 active site 1093787007190 non-prolyl cis peptide bond; other site 1093787007191 insertion regions; other site 1093787007192 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1093787007193 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787007194 substrate binding pocket [chemical binding]; other site 1093787007195 membrane-bound complex binding site; other site 1093787007196 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1093787007197 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1093787007198 dimer interface [polypeptide binding]; other site 1093787007199 active site 1093787007200 non-prolyl cis peptide bond; other site 1093787007201 insertion regions; other site 1093787007202 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1093787007203 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1093787007204 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1093787007205 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787007206 substrate binding pocket [chemical binding]; other site 1093787007207 membrane-bound complex binding site; other site 1093787007208 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787007209 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1093787007210 membrane-bound complex binding site; other site 1093787007211 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1093787007212 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787007213 substrate binding pocket [chemical binding]; other site 1093787007214 membrane-bound complex binding site; other site 1093787007215 hinge residues; other site 1093787007216 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1093787007217 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1093787007218 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1093787007219 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787007220 DNA binding residues [nucleotide binding] 1093787007221 dimerization interface [polypeptide binding]; other site 1093787007222 Secretin and TonB N terminus short domain; Region: STN; smart00965 1093787007223 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1093787007224 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787007225 N-terminal plug; other site 1093787007226 ligand-binding site [chemical binding]; other site 1093787007227 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 1093787007228 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1093787007229 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1093787007230 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1093787007231 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787007232 hypothetical protein; Provisional; Region: PRK06753 1093787007233 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1093787007234 response regulator; Provisional; Region: PRK09483 1093787007235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787007236 active site 1093787007237 phosphorylation site [posttranslational modification] 1093787007238 intermolecular recognition site; other site 1093787007239 dimerization interface [polypeptide binding]; other site 1093787007240 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787007241 DNA binding residues [nucleotide binding] 1093787007242 dimerization interface [polypeptide binding]; other site 1093787007243 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1093787007244 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1093787007245 GIY-YIG motif/motif A; other site 1093787007246 active site 1093787007247 catalytic site [active] 1093787007248 putative DNA binding site [nucleotide binding]; other site 1093787007249 metal binding site [ion binding]; metal-binding site 1093787007250 UvrB/uvrC motif; Region: UVR; pfam02151 1093787007251 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1093787007252 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1093787007253 DNA binding site [nucleotide binding] 1093787007254 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1093787007255 integrase; Provisional; Region: PRK09692 1093787007256 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1093787007257 active site 1093787007258 Int/Topo IB signature motif; other site 1093787007259 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1093787007260 Helix-turn-helix domain; Region: HTH_38; pfam13936 1093787007261 Helix-turn-helix domain; Region: HTH_17; pfam12728 1093787007262 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1093787007263 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787007264 Walker A motif; other site 1093787007265 ATP binding site [chemical binding]; other site 1093787007266 Walker B motif; other site 1093787007267 arginine finger; other site 1093787007268 Outer membrane efflux protein; Region: OEP; pfam02321 1093787007269 Outer membrane efflux protein; Region: OEP; pfam02321 1093787007270 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1093787007271 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1093787007272 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1093787007273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1093787007274 HTH-like domain; Region: HTH_21; pfam13276 1093787007275 Integrase core domain; Region: rve; pfam00665 1093787007276 Integrase core domain; Region: rve_3; pfam13683 1093787007277 Transposase; Region: HTH_Tnp_1; pfam01527 1093787007278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1093787007279 non-specific DNA binding site [nucleotide binding]; other site 1093787007280 salt bridge; other site 1093787007281 sequence-specific DNA binding site [nucleotide binding]; other site 1093787007282 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787007283 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787007284 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1093787007285 dimerization interface [polypeptide binding]; other site 1093787007286 substrate binding pocket [chemical binding]; other site 1093787007287 Copper resistance protein K; Region: CopK; pfam11525 1093787007288 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1093787007289 CopC domain; Region: CopC; pfam04234 1093787007290 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1093787007291 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1093787007292 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1093787007293 motif II; other site 1093787007294 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 1093787007295 Predicted metal-binding protein [General function prediction only]; Region: COG3019 1093787007296 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 1093787007297 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1093787007298 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1093787007299 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1093787007300 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 1093787007301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787007302 active site 1093787007303 phosphorylation site [posttranslational modification] 1093787007304 intermolecular recognition site; other site 1093787007305 dimerization interface [polypeptide binding]; other site 1093787007306 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787007307 DNA binding site [nucleotide binding] 1093787007308 sensor kinase CusS; Provisional; Region: PRK09835 1093787007309 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787007310 dimerization interface [polypeptide binding]; other site 1093787007311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787007312 dimer interface [polypeptide binding]; other site 1093787007313 phosphorylation site [posttranslational modification] 1093787007314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787007315 ATP binding site [chemical binding]; other site 1093787007316 Mg2+ binding site [ion binding]; other site 1093787007317 G-X-G motif; other site 1093787007318 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1093787007319 putative DNA binding site [nucleotide binding]; other site 1093787007320 putative Zn2+ binding site [ion binding]; other site 1093787007321 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1093787007322 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1093787007323 putative metal binding site [ion binding]; other site 1093787007324 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1093787007325 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1093787007326 active site 1093787007327 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1093787007328 arsenical-resistance protein; Region: acr3; TIGR00832 1093787007329 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1093787007330 ArsC family; Region: ArsC; pfam03960 1093787007331 catalytic residues [active] 1093787007332 Predicted transcriptional regulators [Transcription]; Region: COG1695 1093787007333 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1093787007334 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1093787007335 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1093787007336 Chromate transporter; Region: Chromate_transp; pfam02417 1093787007337 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787007338 Coenzyme A binding pocket [chemical binding]; other site 1093787007339 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1093787007340 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787007341 HlyD family secretion protein; Region: HlyD; pfam00529 1093787007342 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787007343 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1093787007344 Putative helicase; Region: TraI_2; pfam07514 1093787007345 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 1093787007346 RES domain; Region: RES; smart00953 1093787007347 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 1093787007348 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 1093787007349 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 1093787007350 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 1093787007351 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1093787007352 MPN+ (JAMM) motif; other site 1093787007353 Zinc-binding site [ion binding]; other site 1093787007354 Thioredoxin; Region: Thioredoxin_4; cl17273 1093787007355 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 1093787007356 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 1093787007357 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 1093787007358 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1093787007359 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 1093787007360 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 1093787007361 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 1093787007362 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 1093787007363 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 1093787007364 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 1093787007365 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 1093787007366 DNA binding domain, excisionase family; Region: excise; TIGR01764 1093787007367 PIN domain; Region: PIN_3; pfam13470 1093787007368 AAA domain; Region: AAA_25; pfam13481 1093787007369 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1093787007370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787007371 Walker A motif; other site 1093787007372 ATP binding site [chemical binding]; other site 1093787007373 Walker B motif; other site 1093787007374 arginine finger; other site 1093787007375 HORMA domain; Region: HORMA; pfam02301 1093787007376 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 1093787007377 active site 1093787007378 NTP binding site [chemical binding]; other site 1093787007379 metal binding triad [ion binding]; metal-binding site 1093787007380 AAA domain; Region: AAA_23; pfam13476 1093787007381 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1093787007382 AAA domain; Region: AAA_21; pfam13304 1093787007383 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787007384 ABC transporter signature motif; other site 1093787007385 Walker B; other site 1093787007386 D-loop; other site 1093787007387 H-loop/switch region; other site 1093787007388 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 1093787007389 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 1093787007390 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 1093787007391 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 1093787007392 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1093787007393 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1093787007394 catalytic residue [active] 1093787007395 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 1093787007396 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 1093787007397 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1093787007398 nucleotide binding region [chemical binding]; other site 1093787007399 ATP-binding site [chemical binding]; other site 1093787007400 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 1093787007401 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1093787007402 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1093787007403 putative active site [active] 1093787007404 putative NTP binding site [chemical binding]; other site 1093787007405 putative nucleic acid binding site [nucleotide binding]; other site 1093787007406 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1093787007407 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1093787007408 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1093787007409 active site 1093787007410 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1093787007411 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1093787007412 ATP binding site [chemical binding]; other site 1093787007413 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1093787007414 S-adenosylmethionine binding site [chemical binding]; other site 1093787007415 Protein of unknown function (DUF3275); Region: DUF3275; pfam11679 1093787007416 Domain of unknown function (DUF932); Region: DUF932; pfam06067 1093787007417 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 1093787007418 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 1093787007419 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 1093787007420 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1093787007421 putative mercuric reductase; Provisional; Region: PRK13748 1093787007422 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1093787007423 metal-binding site [ion binding] 1093787007424 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1093787007425 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1093787007426 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1093787007427 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1093787007428 metal-binding site [ion binding] 1093787007429 putative mercuric transport protein; Provisional; Region: PRK13751 1093787007430 putative transcriptional regulator MerR; Provisional; Region: PRK13752 1093787007431 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 1093787007432 DNA binding residues [nucleotide binding] 1093787007433 dimer interface [polypeptide binding]; other site 1093787007434 mercury binding site [ion binding]; other site 1093787007435 Herpesvirus UL36 tegument protein; Region: Herpes_UL36; pfam03586 1093787007436 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1093787007437 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1093787007438 metal-binding site [ion binding] 1093787007439 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1093787007440 metal-binding site [ion binding] 1093787007441 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1093787007442 metal-binding site [ion binding] 1093787007443 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1093787007444 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1093787007445 metal-binding site [ion binding] 1093787007446 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1093787007447 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 1093787007448 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 1093787007449 DNA binding residues [nucleotide binding] 1093787007450 dimer interface [polypeptide binding]; other site 1093787007451 putative metal binding site [ion binding]; other site 1093787007452 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1093787007453 Cation efflux family; Region: Cation_efflux; cl00316 1093787007454 DNA topoisomerase III; Provisional; Region: PRK07726 1093787007455 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1093787007456 active site 1093787007457 putative interdomain interaction site [polypeptide binding]; other site 1093787007458 putative metal-binding site [ion binding]; other site 1093787007459 putative nucleotide binding site [chemical binding]; other site 1093787007460 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1093787007461 domain I; other site 1093787007462 DNA binding groove [nucleotide binding] 1093787007463 phosphate binding site [ion binding]; other site 1093787007464 domain II; other site 1093787007465 domain III; other site 1093787007466 nucleotide binding site [chemical binding]; other site 1093787007467 catalytic site [active] 1093787007468 domain IV; other site 1093787007469 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1093787007470 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1093787007471 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1093787007472 dimer interface [polypeptide binding]; other site 1093787007473 ssDNA binding site [nucleotide binding]; other site 1093787007474 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1093787007475 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 1093787007476 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 1093787007477 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 1093787007478 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 1093787007479 ParB-like nuclease domain; Region: ParBc; pfam02195 1093787007480 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1093787007481 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1093787007482 Magnesium ion binding site [ion binding]; other site 1093787007483 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1093787007484 Domain of unknown function (DUF305); Region: DUF305; cl17794 1093787007485 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1093787007486 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787007487 substrate binding pocket [chemical binding]; other site 1093787007488 membrane-bound complex binding site; other site 1093787007489 hinge residues; other site 1093787007490 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1093787007491 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787007492 substrate binding pocket [chemical binding]; other site 1093787007493 membrane-bound complex binding site; other site 1093787007494 hinge residues; other site 1093787007495 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787007496 dimer interface [polypeptide binding]; other site 1093787007497 phosphorylation site [posttranslational modification] 1093787007498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787007499 ATP binding site [chemical binding]; other site 1093787007500 Mg2+ binding site [ion binding]; other site 1093787007501 G-X-G motif; other site 1093787007502 Response regulator receiver domain; Region: Response_reg; pfam00072 1093787007503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787007504 active site 1093787007505 phosphorylation site [posttranslational modification] 1093787007506 intermolecular recognition site; other site 1093787007507 dimerization interface [polypeptide binding]; other site 1093787007508 Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109 1093787007509 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 1093787007510 putative RNA binding sites [nucleotide binding]; other site 1093787007511 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1093787007512 Tryptophan 2,3-dioxygenase (vermilion) [Amino acid transport and metabolism]; Region: TDO2; COG3483 1093787007513 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1093787007514 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1093787007515 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1093787007516 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1093787007517 putative DNA binding site [nucleotide binding]; other site 1093787007518 putative Zn2+ binding site [ion binding]; other site 1093787007519 AsnC family; Region: AsnC_trans_reg; pfam01037 1093787007520 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1093787007521 EamA-like transporter family; Region: EamA; pfam00892 1093787007522 EamA-like transporter family; Region: EamA; pfam00892 1093787007523 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1093787007524 dimer interface [polypeptide binding]; other site 1093787007525 FMN binding site [chemical binding]; other site 1093787007526 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1093787007527 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1093787007528 Di-iron ligands [ion binding]; other site 1093787007529 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1093787007530 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787007531 dimerization interface [polypeptide binding]; other site 1093787007532 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787007533 dimer interface [polypeptide binding]; other site 1093787007534 putative CheW interface [polypeptide binding]; other site 1093787007535 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1093787007536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787007537 active site 1093787007538 phosphorylation site [posttranslational modification] 1093787007539 intermolecular recognition site; other site 1093787007540 dimerization interface [polypeptide binding]; other site 1093787007541 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1093787007542 Zn2+ binding site [ion binding]; other site 1093787007543 Mg2+ binding site [ion binding]; other site 1093787007544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787007545 ATP binding site [chemical binding]; other site 1093787007546 Mg2+ binding site [ion binding]; other site 1093787007547 G-X-G motif; other site 1093787007548 PA-IL-like protein; Region: PA-IL; pfam07828 1093787007549 GAF domain; Region: GAF; pfam01590 1093787007550 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1093787007551 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787007552 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787007553 metal binding site [ion binding]; metal-binding site 1093787007554 active site 1093787007555 I-site; other site 1093787007556 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1093787007557 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1093787007558 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1093787007559 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1093787007560 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1093787007561 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 1093787007562 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787007563 dimerization interface [polypeptide binding]; other site 1093787007564 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1093787007565 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787007566 dimer interface [polypeptide binding]; other site 1093787007567 putative CheW interface [polypeptide binding]; other site 1093787007568 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1093787007569 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1093787007570 MgtC family; Region: MgtC; pfam02308 1093787007571 AMP-binding domain protein; Validated; Region: PRK08315 1093787007572 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1093787007573 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1093787007574 acyl-activating enzyme (AAE) consensus motif; other site 1093787007575 putative AMP binding site [chemical binding]; other site 1093787007576 putative active site [active] 1093787007577 putative CoA binding site [chemical binding]; other site 1093787007578 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1093787007579 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1093787007580 SurA N-terminal domain; Region: SurA_N; pfam09312 1093787007581 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787007582 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1093787007583 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1093787007584 acyl-activating enzyme (AAE) consensus motif; other site 1093787007585 AMP binding site [chemical binding]; other site 1093787007586 active site 1093787007587 CoA binding site [chemical binding]; other site 1093787007588 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1093787007589 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1093787007590 NAD binding site [chemical binding]; other site 1093787007591 homodimer interface [polypeptide binding]; other site 1093787007592 homotetramer interface [polypeptide binding]; other site 1093787007593 active site 1093787007594 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1093787007595 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1093787007596 dimer interface [polypeptide binding]; other site 1093787007597 active site 1093787007598 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787007599 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1093787007600 active site 1093787007601 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1093787007602 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787007603 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1093787007604 substrate binding pocket [chemical binding]; other site 1093787007605 dimerization interface [polypeptide binding]; other site 1093787007606 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1093787007607 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1093787007608 FAD binding site [chemical binding]; other site 1093787007609 substrate binding site [chemical binding]; other site 1093787007610 catalytic base [active] 1093787007611 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1093787007612 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1093787007613 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1093787007614 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1093787007615 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1093787007616 ligand binding site [chemical binding]; other site 1093787007617 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787007618 LysR family transcriptional regulator; Provisional; Region: PRK14997 1093787007619 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1093787007620 putative effector binding pocket; other site 1093787007621 dimerization interface [polypeptide binding]; other site 1093787007622 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1093787007623 dimer interface [polypeptide binding]; other site 1093787007624 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1093787007625 metal binding site [ion binding]; metal-binding site 1093787007626 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1093787007627 putative catalytic site [active] 1093787007628 putative phosphate binding site [ion binding]; other site 1093787007629 active site 1093787007630 metal binding site A [ion binding]; metal-binding site 1093787007631 DNA binding site [nucleotide binding] 1093787007632 putative AP binding site [nucleotide binding]; other site 1093787007633 putative metal binding site B [ion binding]; other site 1093787007634 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1093787007635 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1093787007636 Coenzyme A binding pocket [chemical binding]; other site 1093787007637 potential frameshift: common BLAST hit: gi|218891478|ref|YP_002440345.1| putative outer membrane protein 1093787007638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1093787007639 Family of unknown function (DUF490); Region: DUF490; pfam04357 1093787007640 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1093787007641 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1093787007642 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1093787007643 Putative methyltransferase; Region: Methyltransf_20; pfam12147 1093787007644 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1093787007645 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1093787007646 active site 1093787007647 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 1093787007648 active site 1093787007649 catalytic residues [active] 1093787007650 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1093787007651 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1093787007652 putative acyl-acceptor binding pocket; other site 1093787007653 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 1093787007654 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1093787007655 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1093787007656 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1093787007657 active site 1093787007658 catalytic tetrad [active] 1093787007659 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787007660 LysR family transcriptional regulator; Provisional; Region: PRK14997 1093787007661 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1093787007662 putative effector binding pocket; other site 1093787007663 putative dimerization interface [polypeptide binding]; other site 1093787007664 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1093787007665 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1093787007666 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1093787007667 dimer interface [polypeptide binding]; other site 1093787007668 catalytic triad [active] 1093787007669 peroxidatic and resolving cysteines [active] 1093787007670 putative aminotransferase; Provisional; Region: PRK09105 1093787007671 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1093787007672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787007673 homodimer interface [polypeptide binding]; other site 1093787007674 catalytic residue [active] 1093787007675 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1093787007676 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1093787007677 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1093787007678 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787007679 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787007680 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1093787007681 Protein export membrane protein; Region: SecD_SecF; cl14618 1093787007682 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 1093787007683 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1093787007684 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1093787007685 synaptic vesicle protein SV2; Region: synapt_SV2; TIGR01299 1093787007686 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1093787007687 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787007688 dimerization interface [polypeptide binding]; other site 1093787007689 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787007690 dimer interface [polypeptide binding]; other site 1093787007691 phosphorylation site [posttranslational modification] 1093787007692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787007693 ATP binding site [chemical binding]; other site 1093787007694 Mg2+ binding site [ion binding]; other site 1093787007695 G-X-G motif; other site 1093787007696 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1093787007697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787007698 active site 1093787007699 phosphorylation site [posttranslational modification] 1093787007700 intermolecular recognition site; other site 1093787007701 dimerization interface [polypeptide binding]; other site 1093787007702 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787007703 DNA binding site [nucleotide binding] 1093787007704 Outer membrane efflux protein; Region: OEP; pfam02321 1093787007705 Outer membrane efflux protein; Region: OEP; pfam02321 1093787007706 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787007707 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1093787007708 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787007709 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1093787007710 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1093787007711 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787007712 Helix-turn-helix domain; Region: HTH_18; pfam12833 1093787007713 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787007714 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1093787007715 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 1093787007716 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1093787007717 putative alpha subunit interface [polypeptide binding]; other site 1093787007718 putative active site [active] 1093787007719 putative substrate binding site [chemical binding]; other site 1093787007720 Fe binding site [ion binding]; other site 1093787007721 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1093787007722 inter-subunit interface; other site 1093787007723 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1093787007724 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1093787007725 catalytic loop [active] 1093787007726 iron binding site [ion binding]; other site 1093787007727 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1093787007728 FAD binding pocket [chemical binding]; other site 1093787007729 FAD binding motif [chemical binding]; other site 1093787007730 phosphate binding motif [ion binding]; other site 1093787007731 beta-alpha-beta structure motif; other site 1093787007732 NAD binding pocket [chemical binding]; other site 1093787007733 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 1093787007734 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 1093787007735 putative NAD(P) binding site [chemical binding]; other site 1093787007736 active site 1093787007737 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1093787007738 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1093787007739 catalytic loop [active] 1093787007740 iron binding site [ion binding]; other site 1093787007741 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1093787007742 FAD binding pocket [chemical binding]; other site 1093787007743 FAD binding motif [chemical binding]; other site 1093787007744 phosphate binding motif [ion binding]; other site 1093787007745 beta-alpha-beta structure motif; other site 1093787007746 NAD binding pocket [chemical binding]; other site 1093787007747 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1093787007748 inter-subunit interface; other site 1093787007749 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 1093787007750 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1093787007751 [2Fe-2S] cluster binding site [ion binding]; other site 1093787007752 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1093787007753 putative alpha subunit interface [polypeptide binding]; other site 1093787007754 putative active site [active] 1093787007755 putative substrate binding site [chemical binding]; other site 1093787007756 Fe binding site [ion binding]; other site 1093787007757 Helix-turn-helix domain; Region: HTH_18; pfam12833 1093787007758 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1093787007759 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787007760 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787007761 dimerization interface [polypeptide binding]; other site 1093787007762 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 1093787007763 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 1093787007764 octamer interface [polypeptide binding]; other site 1093787007765 active site 1093787007766 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 1093787007767 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 1093787007768 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 1093787007769 dimer interface [polypeptide binding]; other site 1093787007770 active site 1093787007771 outer membrane porin, OprD family; Region: OprD; pfam03573 1093787007772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4859 1093787007773 Leucine rich repeat; Region: LRR_8; pfam13855 1093787007774 Leucine rich repeat; Region: LRR_8; pfam13855 1093787007775 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1093787007776 active site 1093787007777 ATP binding site [chemical binding]; other site 1093787007778 substrate binding site [chemical binding]; other site 1093787007779 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1093787007780 activation loop (A-loop); other site 1093787007781 activation loop (A-loop); other site 1093787007782 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1093787007783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787007784 putative substrate translocation pore; other site 1093787007785 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1093787007786 nucleoside/Zn binding site; other site 1093787007787 dimer interface [polypeptide binding]; other site 1093787007788 catalytic motif [active] 1093787007789 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1093787007790 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1093787007791 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1093787007792 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1093787007793 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787007794 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787007795 dimerization interface [polypeptide binding]; other site 1093787007796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1093787007797 DinB superfamily; Region: DinB_2; pfam12867 1093787007798 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1093787007799 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 1093787007800 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1093787007801 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787007802 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787007803 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787007804 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787007805 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1093787007806 putative substrate binding pocket [chemical binding]; other site 1093787007807 putative dimerization interface [polypeptide binding]; other site 1093787007808 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 1093787007809 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1093787007810 putative NAD(P) binding site [chemical binding]; other site 1093787007811 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1093787007812 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1093787007813 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787007814 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1093787007815 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787007816 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787007817 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787007818 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1093787007819 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1093787007820 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1093787007821 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1093787007822 Cytochrome c; Region: Cytochrom_C; cl11414 1093787007823 Cytochrome c [Energy production and conversion]; Region: COG3258 1093787007824 Cytochrome c; Region: Cytochrom_C; pfam00034 1093787007825 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1093787007826 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787007827 dimer interface [polypeptide binding]; other site 1093787007828 phosphorylation site [posttranslational modification] 1093787007829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787007830 ATP binding site [chemical binding]; other site 1093787007831 G-X-G motif; other site 1093787007832 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1093787007833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787007834 active site 1093787007835 phosphorylation site [posttranslational modification] 1093787007836 intermolecular recognition site; other site 1093787007837 dimerization interface [polypeptide binding]; other site 1093787007838 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787007839 DNA binding site [nucleotide binding] 1093787007840 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 1093787007841 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1093787007842 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1093787007843 DsbD alpha interface [polypeptide binding]; other site 1093787007844 catalytic residues [active] 1093787007845 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 1093787007846 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1093787007847 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1093787007848 catalytic residues [active] 1093787007849 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1093787007850 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1093787007851 dimerization domain [polypeptide binding]; other site 1093787007852 dimer interface [polypeptide binding]; other site 1093787007853 catalytic residues [active] 1093787007854 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1093787007855 Cytochrome P450; Region: p450; cl12078 1093787007856 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 1093787007857 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1093787007858 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1093787007859 C-terminal domain interface [polypeptide binding]; other site 1093787007860 GSH binding site (G-site) [chemical binding]; other site 1093787007861 putative dimer interface [polypeptide binding]; other site 1093787007862 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1093787007863 dimer interface [polypeptide binding]; other site 1093787007864 N-terminal domain interface [polypeptide binding]; other site 1093787007865 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1093787007866 benzoate transport; Region: 2A0115; TIGR00895 1093787007867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787007868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787007869 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1093787007870 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1093787007871 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 1093787007872 Cupin domain; Region: Cupin_2; pfam07883 1093787007873 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787007874 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1093787007875 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787007876 dimerization interface [polypeptide binding]; other site 1093787007877 RNA polymerase sigma factor; Provisional; Region: PRK12528 1093787007878 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1093787007879 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1093787007880 DNA binding residues [nucleotide binding] 1093787007881 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1093787007882 FecR protein; Region: FecR; pfam04773 1093787007883 Secretin and TonB N terminus short domain; Region: STN; smart00965 1093787007884 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1093787007885 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787007886 N-terminal plug; other site 1093787007887 ligand-binding site [chemical binding]; other site 1093787007888 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1093787007889 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1093787007890 RHS Repeat; Region: RHS_repeat; pfam05593 1093787007891 RHS Repeat; Region: RHS_repeat; pfam05593 1093787007892 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1093787007893 RHS Repeat; Region: RHS_repeat; pfam05593 1093787007894 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1093787007895 RHS Repeat; Region: RHS_repeat; pfam05593 1093787007896 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1093787007897 RHS Repeat; Region: RHS_repeat; pfam05593 1093787007898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787007899 Coenzyme A binding pocket [chemical binding]; other site 1093787007900 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1093787007901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787007902 S-adenosylmethionine binding site [chemical binding]; other site 1093787007903 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1093787007904 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1093787007905 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1093787007906 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1093787007907 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 1093787007908 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1093787007909 putative aromatic amino acid binding site; other site 1093787007910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787007911 Walker A motif; other site 1093787007912 ATP binding site [chemical binding]; other site 1093787007913 Walker B motif; other site 1093787007914 arginine finger; other site 1093787007915 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1093787007916 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1093787007917 active site 1093787007918 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1093787007919 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787007920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787007921 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1093787007922 dimerization interface [polypeptide binding]; other site 1093787007923 putative effector binding pocket; other site 1093787007924 glycine cleavage system protein H; Provisional; Region: PRK13380 1093787007925 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1093787007926 lipoyl attachment site [posttranslational modification]; other site 1093787007927 glycine dehydrogenase; Provisional; Region: PRK05367 1093787007928 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1093787007929 tetramer interface [polypeptide binding]; other site 1093787007930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787007931 catalytic residue [active] 1093787007932 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1093787007933 tetramer interface [polypeptide binding]; other site 1093787007934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787007935 catalytic residue [active] 1093787007936 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1093787007937 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1093787007938 dimer interface [polypeptide binding]; other site 1093787007939 active site 1093787007940 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1093787007941 folate binding site [chemical binding]; other site 1093787007942 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1093787007943 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1093787007944 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1093787007945 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 1093787007946 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1093787007947 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The...; Region: SANT; cl17250 1093787007948 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1093787007949 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1093787007950 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1093787007951 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1093787007952 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1093787007953 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1093787007954 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787007955 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787007956 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1093787007957 putative effector binding pocket; other site 1093787007958 dimerization interface [polypeptide binding]; other site 1093787007959 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1093787007960 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1093787007961 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 1093787007962 multidrug resistance protein MdtN; Provisional; Region: PRK10476 1093787007963 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787007964 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787007965 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1093787007966 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1093787007967 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1093787007968 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 1093787007969 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1093787007970 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1093787007971 DNA binding residues [nucleotide binding] 1093787007972 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1093787007973 peptide synthase; Validated; Region: PRK05691 1093787007974 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1093787007975 acyl-activating enzyme (AAE) consensus motif; other site 1093787007976 active site 1093787007977 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1093787007978 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1093787007979 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1093787007980 acyl-activating enzyme (AAE) consensus motif; other site 1093787007981 AMP binding site [chemical binding]; other site 1093787007982 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1093787007983 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1093787007984 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1093787007985 acyl-activating enzyme (AAE) consensus motif; other site 1093787007986 AMP binding site [chemical binding]; other site 1093787007987 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1093787007988 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1093787007989 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1093787007990 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1093787007991 acyl-activating enzyme (AAE) consensus motif; other site 1093787007992 AMP binding site [chemical binding]; other site 1093787007993 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1093787007994 Prophage antirepressor [Transcription]; Region: COG3617 1093787007995 BRO family, N-terminal domain; Region: Bro-N; smart01040 1093787007996 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 1093787007997 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 1093787007998 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736 1093787007999 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735 1093787008000 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 1093787008001 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 1093787008002 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1093787008003 HTH-like domain; Region: HTH_21; pfam13276 1093787008004 Integrase core domain; Region: rve; pfam00665 1093787008005 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1093787008006 Integrase core domain; Region: rve_3; pfam13683 1093787008007 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1093787008008 Transposase; Region: HTH_Tnp_1; pfam01527 1093787008009 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 1093787008010 outer membrane porin, OprD family; Region: OprD; pfam03573 1093787008011 Isochorismatase family; Region: Isochorismatase; pfam00857 1093787008012 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1093787008013 catalytic triad [active] 1093787008014 dimer interface [polypeptide binding]; other site 1093787008015 conserved cis-peptide bond; other site 1093787008016 Pirin-related protein [General function prediction only]; Region: COG1741 1093787008017 Pirin; Region: Pirin; pfam02678 1093787008018 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1093787008019 LysR family transcriptional regulator; Provisional; Region: PRK14997 1093787008020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787008021 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1093787008022 putative effector binding pocket; other site 1093787008023 putative dimerization interface [polypeptide binding]; other site 1093787008024 trehalase; Provisional; Region: treA; PRK13272 1093787008025 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 1093787008026 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1093787008027 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1093787008028 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 1093787008029 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1093787008030 inhibitor-cofactor binding pocket; inhibition site 1093787008031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787008032 catalytic residue [active] 1093787008033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1093787008034 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1093787008035 Serine hydrolase; Region: Ser_hydrolase; cl17834 1093787008036 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1093787008037 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1093787008038 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1093787008039 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1093787008040 ABC-ATPase subunit interface; other site 1093787008041 dimer interface [polypeptide binding]; other site 1093787008042 putative PBP binding regions; other site 1093787008043 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1093787008044 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787008045 Walker A/P-loop; other site 1093787008046 ATP binding site [chemical binding]; other site 1093787008047 Q-loop/lid; other site 1093787008048 ABC transporter signature motif; other site 1093787008049 Walker B; other site 1093787008050 D-loop; other site 1093787008051 H-loop/switch region; other site 1093787008052 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1093787008053 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1093787008054 intersubunit interface [polypeptide binding]; other site 1093787008055 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1093787008056 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1093787008057 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1093787008058 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1093787008059 Condensation domain; Region: Condensation; pfam00668 1093787008060 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1093787008061 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1093787008062 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1093787008063 acyl-activating enzyme (AAE) consensus motif; other site 1093787008064 AMP binding site [chemical binding]; other site 1093787008065 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1093787008066 Condensation domain; Region: Condensation; pfam00668 1093787008067 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1093787008068 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1093787008069 Condensation domain; Region: Condensation; pfam00668 1093787008070 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1093787008071 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1093787008072 acyl-activating enzyme (AAE) consensus motif; other site 1093787008073 AMP binding site [chemical binding]; other site 1093787008074 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1093787008075 Condensation domain; Region: Condensation; pfam00668 1093787008076 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1093787008077 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1093787008078 Condensation domain; Region: Condensation; pfam00668 1093787008079 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1093787008080 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1093787008081 acyl-activating enzyme (AAE) consensus motif; other site 1093787008082 AMP binding site [chemical binding]; other site 1093787008083 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1093787008084 peptide synthase; Provisional; Region: PRK12467 1093787008085 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1093787008086 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1093787008087 acyl-activating enzyme (AAE) consensus motif; other site 1093787008088 AMP binding site [chemical binding]; other site 1093787008089 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1093787008090 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1093787008091 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1093787008092 acyl-activating enzyme (AAE) consensus motif; other site 1093787008093 AMP binding site [chemical binding]; other site 1093787008094 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1093787008095 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1093787008096 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1093787008097 acyl-activating enzyme (AAE) consensus motif; other site 1093787008098 AMP binding site [chemical binding]; other site 1093787008099 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1093787008100 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1093787008101 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1093787008102 acyl-activating enzyme (AAE) consensus motif; other site 1093787008103 AMP binding site [chemical binding]; other site 1093787008104 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1093787008105 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1093787008106 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1093787008107 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1093787008108 Secretin and TonB N terminus short domain; Region: STN; pfam07660 1093787008109 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1093787008110 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787008111 N-terminal plug; other site 1093787008112 ligand-binding site [chemical binding]; other site 1093787008113 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 1093787008114 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1093787008115 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1093787008116 Walker A/P-loop; other site 1093787008117 ATP binding site [chemical binding]; other site 1093787008118 Q-loop/lid; other site 1093787008119 ABC transporter signature motif; other site 1093787008120 Walker B; other site 1093787008121 D-loop; other site 1093787008122 H-loop/switch region; other site 1093787008123 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1093787008124 catalytic site [active] 1093787008125 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1093787008126 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1093787008127 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1093787008128 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1093787008129 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1093787008130 catalytic residue [active] 1093787008131 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1093787008132 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1093787008133 active site 1093787008134 dimer interface [polypeptide binding]; other site 1093787008135 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1093787008136 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1093787008137 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1093787008138 Walker A/P-loop; other site 1093787008139 ATP binding site [chemical binding]; other site 1093787008140 Q-loop/lid; other site 1093787008141 ABC transporter signature motif; other site 1093787008142 Walker B; other site 1093787008143 D-loop; other site 1093787008144 H-loop/switch region; other site 1093787008145 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1093787008146 FtsX-like permease family; Region: FtsX; pfam02687 1093787008147 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1093787008148 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787008149 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787008150 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1093787008151 FecR protein; Region: FecR; pfam04773 1093787008152 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1093787008153 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1093787008154 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1093787008155 DNA binding residues [nucleotide binding] 1093787008156 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1093787008157 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1093787008158 Penicillin amidase; Region: Penicil_amidase; pfam01804 1093787008159 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1093787008160 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 1093787008161 active site 1093787008162 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1093787008163 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 1093787008164 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1093787008165 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787008166 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787008167 dimerization interface [polypeptide binding]; other site 1093787008168 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1093787008169 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1093787008170 phosphate binding site [ion binding]; other site 1093787008171 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 1093787008172 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1093787008173 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1093787008174 catalytic loop [active] 1093787008175 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1093787008176 iron binding site [ion binding]; other site 1093787008177 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1093787008178 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1093787008179 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1093787008180 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1093787008181 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1093787008182 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1093787008183 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1093787008184 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1093787008185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787008186 active site 1093787008187 phosphorylation site [posttranslational modification] 1093787008188 intermolecular recognition site; other site 1093787008189 dimerization interface [polypeptide binding]; other site 1093787008190 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787008191 DNA binding residues [nucleotide binding] 1093787008192 dimerization interface [polypeptide binding]; other site 1093787008193 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1093787008194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1093787008195 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1093787008196 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1093787008197 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1093787008198 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1093787008199 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1093787008200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787008201 Walker A motif; other site 1093787008202 ATP binding site [chemical binding]; other site 1093787008203 Walker B motif; other site 1093787008204 arginine finger; other site 1093787008205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787008206 Walker A motif; other site 1093787008207 ATP binding site [chemical binding]; other site 1093787008208 Walker B motif; other site 1093787008209 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 1093787008210 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1093787008211 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 1093787008212 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 1093787008213 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1093787008214 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1093787008215 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1093787008216 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 1093787008217 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 1093787008218 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1093787008219 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 1093787008220 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1093787008221 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1093787008222 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1093787008223 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1093787008224 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787008225 Walker A motif; other site 1093787008226 ATP binding site [chemical binding]; other site 1093787008227 Walker B motif; other site 1093787008228 arginine finger; other site 1093787008229 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1093787008230 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 1093787008231 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1093787008232 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1093787008233 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1093787008234 active site 1093787008235 dimer interface [polypeptide binding]; other site 1093787008236 non-prolyl cis peptide bond; other site 1093787008237 insertion regions; other site 1093787008238 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1093787008239 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1093787008240 Flavin binding site [chemical binding]; other site 1093787008241 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1093787008242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787008243 Walker A motif; other site 1093787008244 ATP binding site [chemical binding]; other site 1093787008245 Walker B motif; other site 1093787008246 arginine finger; other site 1093787008247 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1093787008248 Predicted ATPase [General function prediction only]; Region: COG1485 1093787008249 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787008250 Walker B; other site 1093787008251 D-loop; other site 1093787008252 H-loop/switch region; other site 1093787008253 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1093787008254 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1093787008255 active site 1093787008256 catalytic site [active] 1093787008257 metal binding site [ion binding]; metal-binding site 1093787008258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787008259 dimer interface [polypeptide binding]; other site 1093787008260 conserved gate region; other site 1093787008261 ABC-ATPase subunit interface; other site 1093787008262 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1093787008263 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1093787008264 Walker A/P-loop; other site 1093787008265 ATP binding site [chemical binding]; other site 1093787008266 Q-loop/lid; other site 1093787008267 ABC transporter signature motif; other site 1093787008268 Walker B; other site 1093787008269 D-loop; other site 1093787008270 H-loop/switch region; other site 1093787008271 NIL domain; Region: NIL; pfam09383 1093787008272 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1093787008273 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1093787008274 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1093787008275 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1093787008276 active site 1093787008277 non-prolyl cis peptide bond; other site 1093787008278 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1093787008279 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787008280 active site 1093787008281 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1093787008282 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787008283 active site 1093787008284 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1093787008285 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1093787008286 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1093787008287 putative substrate binding site [chemical binding]; other site 1093787008288 putative ATP binding site [chemical binding]; other site 1093787008289 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 1093787008290 N- and C-terminal domain interface [polypeptide binding]; other site 1093787008291 D-xylulose kinase; Region: XylB; TIGR01312 1093787008292 active site 1093787008293 MgATP binding site [chemical binding]; other site 1093787008294 catalytic site [active] 1093787008295 metal binding site [ion binding]; metal-binding site 1093787008296 xylulose binding site [chemical binding]; other site 1093787008297 putative homodimer interface [polypeptide binding]; other site 1093787008298 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1093787008299 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1093787008300 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1093787008301 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1093787008302 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1093787008303 Walker A/P-loop; other site 1093787008304 ATP binding site [chemical binding]; other site 1093787008305 Q-loop/lid; other site 1093787008306 ABC transporter signature motif; other site 1093787008307 Walker B; other site 1093787008308 D-loop; other site 1093787008309 H-loop/switch region; other site 1093787008310 TOBE domain; Region: TOBE_2; pfam08402 1093787008311 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1093787008312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787008313 dimer interface [polypeptide binding]; other site 1093787008314 conserved gate region; other site 1093787008315 ABC-ATPase subunit interface; other site 1093787008316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787008317 dimer interface [polypeptide binding]; other site 1093787008318 conserved gate region; other site 1093787008319 putative PBP binding loops; other site 1093787008320 ABC-ATPase subunit interface; other site 1093787008321 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1093787008322 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1093787008323 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1093787008324 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1093787008325 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787008326 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1093787008327 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1093787008328 substrate binding site [chemical binding]; other site 1093787008329 activation loop (A-loop); other site 1093787008330 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1093787008331 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787008332 N-terminal plug; other site 1093787008333 ligand-binding site [chemical binding]; other site 1093787008334 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787008335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787008336 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1093787008337 dimerization interface [polypeptide binding]; other site 1093787008338 Sulfatase; Region: Sulfatase; cl17466 1093787008339 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1093787008340 Cupin; Region: Cupin_6; pfam12852 1093787008341 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1093787008342 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787008343 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1093787008344 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1093787008345 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787008346 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1093787008347 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1093787008348 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1093787008349 Walker A/P-loop; other site 1093787008350 ATP binding site [chemical binding]; other site 1093787008351 Q-loop/lid; other site 1093787008352 ABC transporter signature motif; other site 1093787008353 Walker B; other site 1093787008354 D-loop; other site 1093787008355 H-loop/switch region; other site 1093787008356 NMT1-like family; Region: NMT1_2; pfam13379 1093787008357 NMT1/THI5 like; Region: NMT1; pfam09084 1093787008358 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1093787008359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787008360 dimer interface [polypeptide binding]; other site 1093787008361 conserved gate region; other site 1093787008362 putative PBP binding loops; other site 1093787008363 ABC-ATPase subunit interface; other site 1093787008364 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1093787008365 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1093787008366 active site 1093787008367 non-prolyl cis peptide bond; other site 1093787008368 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1093787008369 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1093787008370 Flavin binding site [chemical binding]; other site 1093787008371 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1093787008372 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1093787008373 Flavin binding site [chemical binding]; other site 1093787008374 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1093787008375 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1093787008376 tetrameric interface [polypeptide binding]; other site 1093787008377 activator binding site; other site 1093787008378 NADP binding site [chemical binding]; other site 1093787008379 substrate binding site [chemical binding]; other site 1093787008380 catalytic residues [active] 1093787008381 GntP family permease; Region: GntP_permease; pfam02447 1093787008382 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1093787008383 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1093787008384 AAA domain; Region: AAA_33; pfam13671 1093787008385 ATP-binding site [chemical binding]; other site 1093787008386 Gluconate-6-phosphate binding site [chemical binding]; other site 1093787008387 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1093787008388 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1093787008389 DNA binding site [nucleotide binding] 1093787008390 domain linker motif; other site 1093787008391 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1093787008392 putative ligand binding site [chemical binding]; other site 1093787008393 putative dimerization interface [polypeptide binding]; other site 1093787008394 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1093787008395 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1093787008396 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1093787008397 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787008398 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787008399 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 1093787008400 putative dimerization interface [polypeptide binding]; other site 1093787008401 putative effector binding pocket; other site 1093787008402 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1093787008403 Beta-lactamase; Region: Beta-lactamase; pfam00144 1093787008404 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1093787008405 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1093787008406 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1093787008407 non-specific DNA binding site [nucleotide binding]; other site 1093787008408 salt bridge; other site 1093787008409 sequence-specific DNA binding site [nucleotide binding]; other site 1093787008410 Cupin domain; Region: Cupin_2; pfam07883 1093787008411 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1093787008412 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1093787008413 active site 1093787008414 iron coordination sites [ion binding]; other site 1093787008415 substrate binding pocket [chemical binding]; other site 1093787008416 NMT1-like family; Region: NMT1_2; pfam13379 1093787008417 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1093787008418 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1093787008419 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1093787008420 Walker A/P-loop; other site 1093787008421 ATP binding site [chemical binding]; other site 1093787008422 Q-loop/lid; other site 1093787008423 ABC transporter signature motif; other site 1093787008424 Walker B; other site 1093787008425 D-loop; other site 1093787008426 H-loop/switch region; other site 1093787008427 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1093787008428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787008429 putative PBP binding loops; other site 1093787008430 ABC-ATPase subunit interface; other site 1093787008431 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1093787008432 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 1093787008433 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1093787008434 acyl-activating enzyme (AAE) consensus motif; other site 1093787008435 AMP binding site [chemical binding]; other site 1093787008436 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1093787008437 Condensation domain; Region: Condensation; pfam00668 1093787008438 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1093787008439 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1093787008440 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1093787008441 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1093787008442 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1093787008443 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1093787008444 acyl-activating enzyme (AAE) consensus motif; other site 1093787008445 AMP binding site [chemical binding]; other site 1093787008446 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1093787008447 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1093787008448 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1093787008449 Condensation domain; Region: Condensation; pfam00668 1093787008450 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1093787008451 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1093787008452 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 1093787008453 putative deacylase active site [active] 1093787008454 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1093787008455 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1093787008456 putative active site [active] 1093787008457 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1093787008458 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1093787008459 Interdomain contacts; other site 1093787008460 Cytokine receptor motif; other site 1093787008461 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1093787008462 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1093787008463 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787008464 DNA-binding site [nucleotide binding]; DNA binding site 1093787008465 UTRA domain; Region: UTRA; pfam07702 1093787008466 putative oxidoreductase; Provisional; Region: PRK08275 1093787008467 L-aspartate oxidase; Provisional; Region: PRK06175 1093787008468 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1093787008469 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1093787008470 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 1093787008471 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787008472 substrate binding pocket [chemical binding]; other site 1093787008473 membrane-bound complex binding site; other site 1093787008474 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1093787008475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1093787008476 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1093787008477 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1093787008478 Walker A/P-loop; other site 1093787008479 ATP binding site [chemical binding]; other site 1093787008480 Q-loop/lid; other site 1093787008481 ABC transporter signature motif; other site 1093787008482 Walker B; other site 1093787008483 D-loop; other site 1093787008484 H-loop/switch region; other site 1093787008485 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1093787008486 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1093787008487 Protein of unknown function (DUF971); Region: DUF971; cl01414 1093787008488 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 1093787008489 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1093787008490 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1093787008491 Trp docking motif [polypeptide binding]; other site 1093787008492 putative active site [active] 1093787008493 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1093787008494 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787008495 N-terminal plug; other site 1093787008496 ligand-binding site [chemical binding]; other site 1093787008497 Peptidase family M48; Region: Peptidase_M48; cl12018 1093787008498 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1093787008499 Peptidase family M48; Region: Peptidase_M48; cl12018 1093787008500 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1093787008501 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787008502 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1093787008503 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1093787008504 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1093787008505 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1093787008506 active site 1093787008507 arsenical pump membrane protein; Provisional; Region: PRK15445 1093787008508 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1093787008509 transmembrane helices; other site 1093787008510 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1093787008511 dimerization interface [polypeptide binding]; other site 1093787008512 putative DNA binding site [nucleotide binding]; other site 1093787008513 putative Zn2+ binding site [ion binding]; other site 1093787008514 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1093787008515 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1093787008516 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787008517 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1093787008518 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1093787008519 putative NAD(P) binding site [chemical binding]; other site 1093787008520 putative substrate binding site [chemical binding]; other site 1093787008521 catalytic Zn binding site [ion binding]; other site 1093787008522 structural Zn binding site [ion binding]; other site 1093787008523 dimer interface [polypeptide binding]; other site 1093787008524 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1093787008525 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1093787008526 DNA binding residues [nucleotide binding] 1093787008527 dimer interface [polypeptide binding]; other site 1093787008528 [2Fe-2S] cluster binding site [ion binding]; other site 1093787008529 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1093787008530 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1093787008531 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1093787008532 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1093787008533 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787008534 Coenzyme A binding pocket [chemical binding]; other site 1093787008535 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787008536 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787008537 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1093787008538 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1093787008539 conserved cys residue [active] 1093787008540 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1093787008541 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787008542 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787008543 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787008544 dimerization interface [polypeptide binding]; other site 1093787008545 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1093787008546 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1093787008547 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1093787008548 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1093787008549 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1093787008550 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1093787008551 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1093787008552 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1093787008553 dimerization interface [polypeptide binding]; other site 1093787008554 ligand binding site [chemical binding]; other site 1093787008555 NADP binding site [chemical binding]; other site 1093787008556 catalytic site [active] 1093787008557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787008558 D-galactonate transporter; Region: 2A0114; TIGR00893 1093787008559 putative substrate translocation pore; other site 1093787008560 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1093787008561 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1093787008562 substrate binding site [chemical binding]; other site 1093787008563 ATP binding site [chemical binding]; other site 1093787008564 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1093787008565 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1093787008566 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1093787008567 DNA binding site [nucleotide binding] 1093787008568 domain linker motif; other site 1093787008569 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1093787008570 putative dimerization interface [polypeptide binding]; other site 1093787008571 putative ligand binding site [chemical binding]; other site 1093787008572 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787008573 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787008574 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1093787008575 putative effector binding pocket; other site 1093787008576 dimerization interface [polypeptide binding]; other site 1093787008577 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1093787008578 Cytochrome c; Region: Cytochrom_C; cl11414 1093787008579 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1093787008580 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1093787008581 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 1093787008582 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1093787008583 substrate binding pocket [chemical binding]; other site 1093787008584 active site 1093787008585 iron coordination sites [ion binding]; other site 1093787008586 Pyoverdine/dityrosine biosynthesis protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: DIT1; COG3207 1093787008587 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 1093787008588 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1093787008589 active site 1093787008590 homodimer interface [polypeptide binding]; other site 1093787008591 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1093787008592 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1093787008593 Helix-turn-helix domain; Region: HTH_19; pfam12844 1093787008594 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1093787008595 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1093787008596 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1093787008597 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1093787008598 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1093787008599 E3 interaction surface; other site 1093787008600 lipoyl attachment site [posttranslational modification]; other site 1093787008601 e3 binding domain; Region: E3_binding; pfam02817 1093787008602 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1093787008603 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1093787008604 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1093787008605 alpha subunit interface [polypeptide binding]; other site 1093787008606 TPP binding site [chemical binding]; other site 1093787008607 heterodimer interface [polypeptide binding]; other site 1093787008608 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1093787008609 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 1093787008610 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1093787008611 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1093787008612 tetramer interface [polypeptide binding]; other site 1093787008613 TPP-binding site [chemical binding]; other site 1093787008614 heterodimer interface [polypeptide binding]; other site 1093787008615 phosphorylation loop region [posttranslational modification] 1093787008616 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1093787008617 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1093787008618 putative DNA binding site [nucleotide binding]; other site 1093787008619 putative Zn2+ binding site [ion binding]; other site 1093787008620 AsnC family; Region: AsnC_trans_reg; pfam01037 1093787008621 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1093787008622 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 1093787008623 active site 1093787008624 DNA binding site [nucleotide binding] 1093787008625 Int/Topo IB signature motif; other site 1093787008626 catalytic residues [active] 1093787008627 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 1093787008628 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1093787008629 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1093787008630 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1093787008631 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1093787008632 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1093787008633 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1093787008634 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1093787008635 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1093787008636 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 1093787008637 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1093787008638 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1093787008639 Chain length determinant protein; Region: Wzz; cl15801 1093787008640 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1093787008641 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1093787008642 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1093787008643 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1093787008644 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1093787008645 active site 1093787008646 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1093787008647 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1093787008648 Substrate binding site; other site 1093787008649 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1093787008650 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1093787008651 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1093787008652 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1093787008653 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1093787008654 catalytic residue [active] 1093787008655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1093787008656 MOSC domain; Region: MOSC; pfam03473 1093787008657 3-alpha domain; Region: 3-alpha; pfam03475 1093787008658 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1093787008659 classical (c) SDRs; Region: SDR_c; cd05233 1093787008660 NAD(P) binding site [chemical binding]; other site 1093787008661 active site 1093787008662 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1093787008663 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1093787008664 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1093787008665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787008666 AAA domain; Region: AAA_21; pfam13304 1093787008667 Walker A/P-loop; other site 1093787008668 ATP binding site [chemical binding]; other site 1093787008669 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1093787008670 putative active site [active] 1093787008671 putative metal-binding site [ion binding]; other site 1093787008672 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1093787008673 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1093787008674 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1093787008675 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1093787008676 active site 1093787008677 NTP binding site [chemical binding]; other site 1093787008678 metal binding triad [ion binding]; metal-binding site 1093787008679 antibiotic binding site [chemical binding]; other site 1093787008680 Uncharacterized conserved protein [Function unknown]; Region: COG2361 1093787008681 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1093787008682 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1093787008683 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1093787008684 catalytic residues [active] 1093787008685 catalytic nucleophile [active] 1093787008686 Presynaptic Site I dimer interface [polypeptide binding]; other site 1093787008687 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1093787008688 Synaptic Flat tetramer interface [polypeptide binding]; other site 1093787008689 Synaptic Site I dimer interface [polypeptide binding]; other site 1093787008690 DNA binding site [nucleotide binding] 1093787008691 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1093787008692 DNA-binding interface [nucleotide binding]; DNA binding site 1093787008693 transposase/IS protein; Provisional; Region: PRK09183 1093787008694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787008695 Walker A motif; other site 1093787008696 ATP binding site [chemical binding]; other site 1093787008697 Walker B motif; other site 1093787008698 arginine finger; other site 1093787008699 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 1093787008700 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1093787008701 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410 1093787008702 Phage protein GP46; Region: GP46; cl01814 1093787008703 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1093787008704 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 1093787008705 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1093787008706 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1093787008707 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787008708 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787008709 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1093787008710 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1093787008711 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1093787008712 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1093787008713 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 1093787008714 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1093787008715 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787008716 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787008717 Chromate transporter; Region: Chromate_transp; pfam02417 1093787008718 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1093787008719 Chromate transporter; Region: Chromate_transp; pfam02417 1093787008720 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 1093787008721 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1093787008722 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1093787008723 catalytic residues [active] 1093787008724 catalytic nucleophile [active] 1093787008725 Presynaptic Site I dimer interface [polypeptide binding]; other site 1093787008726 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1093787008727 Synaptic Flat tetramer interface [polypeptide binding]; other site 1093787008728 Synaptic Site I dimer interface [polypeptide binding]; other site 1093787008729 DNA binding site [nucleotide binding] 1093787008730 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1093787008731 DNA-binding interface [nucleotide binding]; DNA binding site 1093787008732 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1093787008733 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1093787008734 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 1093787008735 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 1093787008736 DNA binding site [nucleotide binding] 1093787008737 dimer interface [polypeptide binding]; other site 1093787008738 active site 1093787008739 Int/Topo IB signature motif; other site 1093787008740 Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505 1093787008741 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 1093787008742 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1093787008743 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787008744 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1093787008745 Coenzyme A binding pocket [chemical binding]; other site 1093787008746 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1093787008747 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1093787008748 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1093787008749 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 1093787008750 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1093787008751 active site 1093787008752 DNA binding site [nucleotide binding] 1093787008753 Int/Topo IB signature motif; other site 1093787008754 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1093787008755 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1093787008756 potential frameshift: common BLAST hit: gi|124267541|ref|YP_001021545.1| sterol desaturase-like protein 1093787008757 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1093787008758 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1093787008759 Helix-turn-helix domain; Region: HTH_18; pfam12833 1093787008760 Outer membrane efflux protein; Region: OEP; pfam02321 1093787008761 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 1093787008762 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787008763 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 1093787008764 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1093787008765 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1093787008766 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 1093787008767 DNA binding site [nucleotide binding] 1093787008768 dimer interface [polypeptide binding]; other site 1093787008769 active site 1093787008770 Int/Topo IB signature motif; other site 1093787008771 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 1093787008772 Transposase domain (DUF772); Region: DUF772; pfam05598 1093787008773 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1093787008774 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1093787008775 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1093787008776 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 1093787008777 AAA domain; Region: AAA_22; pfam13401 1093787008778 Integrase core domain; Region: rve; pfam00665 1093787008779 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1093787008780 active site 1093787008781 Int/Topo IB signature motif; other site 1093787008782 DNA binding site [nucleotide binding] 1093787008783 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1093787008784 DNA binding site [nucleotide binding] 1093787008785 active site 1093787008786 Int/Topo IB signature motif; other site 1093787008787 Integrase core domain; Region: rve_3; cl15866 1093787008788 potential frameshift: common BLAST hit: gi|339321743|ref|YP_004680637.1| integrase 1093787008789 Integrase core domain; Region: rve_2; pfam13333 1093787008790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787008791 AAA domain; Region: AAA_21; pfam13304 1093787008792 Walker A/P-loop; other site 1093787008793 ATP binding site [chemical binding]; other site 1093787008794 Protein of unknown function (DUF3223); Region: DUF3223; pfam11523 1093787008795 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787008796 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787008797 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1093787008798 putative effector binding pocket; other site 1093787008799 putative dimerization interface [polypeptide binding]; other site 1093787008800 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1093787008801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787008802 putative substrate translocation pore; other site 1093787008803 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1093787008804 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1093787008805 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1093787008806 dimer interface [polypeptide binding]; other site 1093787008807 NADP binding site [chemical binding]; other site 1093787008808 catalytic residues [active] 1093787008809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 1093787008810 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1093787008811 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1093787008812 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1093787008813 putative active site pocket [active] 1093787008814 putative metal binding site [ion binding]; other site 1093787008815 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1093787008816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787008817 putative substrate translocation pore; other site 1093787008818 outer membrane porin, OprD family; Region: OprD; pfam03573 1093787008819 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1093787008820 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1093787008821 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1093787008822 Amidohydrolase; Region: Amidohydro_2; pfam04909 1093787008823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787008824 D-galactonate transporter; Region: 2A0114; TIGR00893 1093787008825 putative substrate translocation pore; other site 1093787008826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1093787008827 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1093787008828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1093787008829 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787008830 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787008831 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787008832 dimerization interface [polypeptide binding]; other site 1093787008833 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1093787008834 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787008835 substrate binding pocket [chemical binding]; other site 1093787008836 membrane-bound complex binding site; other site 1093787008837 hinge residues; other site 1093787008838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787008839 dimer interface [polypeptide binding]; other site 1093787008840 conserved gate region; other site 1093787008841 putative PBP binding loops; other site 1093787008842 ABC-ATPase subunit interface; other site 1093787008843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787008844 dimer interface [polypeptide binding]; other site 1093787008845 conserved gate region; other site 1093787008846 putative PBP binding loops; other site 1093787008847 ABC-ATPase subunit interface; other site 1093787008848 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 1093787008849 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1093787008850 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1093787008851 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1093787008852 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1093787008853 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1093787008854 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1093787008855 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1093787008856 NAD(P) binding site [chemical binding]; other site 1093787008857 substrate binding site [chemical binding]; other site 1093787008858 dimer interface [polypeptide binding]; other site 1093787008859 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787008860 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787008861 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 1093787008862 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1093787008863 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1093787008864 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1093787008865 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1093787008866 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1093787008867 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1093787008868 catalytic loop [active] 1093787008869 iron binding site [ion binding]; other site 1093787008870 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1093787008871 FOG: CBS domain [General function prediction only]; Region: COG0517 1093787008872 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1093787008873 Anthrax toxin LF subunit; Region: Anthrax_toxA; pfam03497 1093787008874 General stress protein [General function prediction only]; Region: GsiB; COG3729 1093787008875 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1093787008876 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1093787008877 active site 1093787008878 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1093787008879 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1093787008880 NAD binding site [chemical binding]; other site 1093787008881 catalytic Zn binding site [ion binding]; other site 1093787008882 structural Zn binding site [ion binding]; other site 1093787008883 Low affinity iron permease; Region: Iron_permease; pfam04120 1093787008884 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1093787008885 dimanganese center [ion binding]; other site 1093787008886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 1093787008887 Predicted membrane protein [Function unknown]; Region: COG3205 1093787008888 carboxylate-amine ligase; Provisional; Region: PRK13515 1093787008889 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1093787008890 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1093787008891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787008892 S-adenosylmethionine binding site [chemical binding]; other site 1093787008893 Yip1 domain; Region: Yip1; cl17815 1093787008894 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787008895 PAS domain; Region: PAS_9; pfam13426 1093787008896 putative active site [active] 1093787008897 heme pocket [chemical binding]; other site 1093787008898 PAS domain S-box; Region: sensory_box; TIGR00229 1093787008899 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787008900 putative active site [active] 1093787008901 heme pocket [chemical binding]; other site 1093787008902 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787008903 dimer interface [polypeptide binding]; other site 1093787008904 phosphorylation site [posttranslational modification] 1093787008905 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787008906 ATP binding site [chemical binding]; other site 1093787008907 Mg2+ binding site [ion binding]; other site 1093787008908 G-X-G motif; other site 1093787008909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787008910 active site 1093787008911 phosphorylation site [posttranslational modification] 1093787008912 intermolecular recognition site; other site 1093787008913 dimerization interface [polypeptide binding]; other site 1093787008914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787008915 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1093787008916 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1093787008917 metal binding site [ion binding]; metal-binding site 1093787008918 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 1093787008919 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1093787008920 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1093787008921 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 1093787008922 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1093787008923 glycogen synthase; Provisional; Region: glgA; PRK00654 1093787008924 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1093787008925 ADP-binding pocket [chemical binding]; other site 1093787008926 homodimer interface [polypeptide binding]; other site 1093787008927 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1093787008928 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1093787008929 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1093787008930 catalytic site [active] 1093787008931 active site 1093787008932 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1093787008933 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1093787008934 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 1093787008935 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1093787008936 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1093787008937 active site 1093787008938 catalytic site [active] 1093787008939 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1093787008940 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1093787008941 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1093787008942 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1093787008943 active site 1093787008944 catalytic site [active] 1093787008945 FOG: CBS domain [General function prediction only]; Region: COG0517 1093787008946 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1093787008947 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1093787008948 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1093787008949 NAD binding site [chemical binding]; other site 1093787008950 catalytic Zn binding site [ion binding]; other site 1093787008951 structural Zn binding site [ion binding]; other site 1093787008952 Protein of unknown function DUF72; Region: DUF72; pfam01904 1093787008953 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1093787008954 putative catalytic site [active] 1093787008955 putative metal binding site [ion binding]; other site 1093787008956 putative phosphate binding site [ion binding]; other site 1093787008957 cardiolipin synthase 2; Provisional; Region: PRK11263 1093787008958 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1093787008959 putative active site [active] 1093787008960 catalytic site [active] 1093787008961 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1093787008962 putative active site [active] 1093787008963 catalytic site [active] 1093787008964 Predicted integral membrane protein [Function unknown]; Region: COG0392 1093787008965 glycogen branching enzyme; Provisional; Region: PRK05402 1093787008966 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1093787008967 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1093787008968 active site 1093787008969 catalytic site [active] 1093787008970 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1093787008971 trehalose synthase; Region: treS_nterm; TIGR02456 1093787008972 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1093787008973 active site 1093787008974 catalytic site [active] 1093787008975 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1093787008976 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1093787008977 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1093787008978 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1093787008979 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1093787008980 active site 1093787008981 homodimer interface [polypeptide binding]; other site 1093787008982 catalytic site [active] 1093787008983 acceptor binding site [chemical binding]; other site 1093787008984 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1093787008985 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1093787008986 putative DNA binding site [nucleotide binding]; other site 1093787008987 putative homodimer interface [polypeptide binding]; other site 1093787008988 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1093787008989 MgtC family; Region: MgtC; pfam02308 1093787008990 hydroperoxidase II; Provisional; Region: katE; PRK11249 1093787008991 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1093787008992 tetramer interface [polypeptide binding]; other site 1093787008993 heme binding pocket [chemical binding]; other site 1093787008994 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1093787008995 domain interactions; other site 1093787008996 General stress protein [General function prediction only]; Region: GsiB; COG3729 1093787008997 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1093787008998 homodimer interface [polypeptide binding]; other site 1093787008999 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1093787009000 active site pocket [active] 1093787009001 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 1093787009002 short chain dehydrogenase; Provisional; Region: PRK06701 1093787009003 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1093787009004 NAD binding site [chemical binding]; other site 1093787009005 metal binding site [ion binding]; metal-binding site 1093787009006 active site 1093787009007 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1093787009008 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 1093787009009 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 1093787009010 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1093787009011 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1093787009012 active site 1093787009013 DNA binding site [nucleotide binding] 1093787009014 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1093787009015 DNA binding site [nucleotide binding] 1093787009016 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 1093787009017 nucleotide binding site [chemical binding]; other site 1093787009018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1093787009019 active site 1093787009020 phosphorylation site [posttranslational modification] 1093787009021 intermolecular recognition site; other site 1093787009022 dimerization interface [polypeptide binding]; other site 1093787009023 Predicted membrane protein [Function unknown]; Region: COG2323 1093787009024 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1093787009025 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1093787009026 Predicted outer membrane protein [Function unknown]; Region: COG3652 1093787009027 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1093787009028 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 1093787009029 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1093787009030 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1093787009031 Fimbrial protein; Region: Fimbrial; cl01416 1093787009032 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1093787009033 PapC N-terminal domain; Region: PapC_N; pfam13954 1093787009034 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1093787009035 PapC C-terminal domain; Region: PapC_C; pfam13953 1093787009036 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1093787009037 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1093787009038 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1093787009039 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1093787009040 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1093787009041 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1093787009042 Active Sites [active] 1093787009043 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1093787009044 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1093787009045 ParB-like nuclease domain; Region: ParBc; pfam02195 1093787009046 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1093787009047 Pseudomonas putida aldehyde dehydrogenase PsfA (ACA09737)-like; Region: ALDH_PsfA-ACA09737; cd07120 1093787009048 NAD(P) binding site [chemical binding]; other site 1093787009049 catalytic residues [active] 1093787009050 choline dehydrogenase; Validated; Region: PRK02106 1093787009051 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1093787009052 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1093787009053 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787009054 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787009055 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1093787009056 putative effector binding pocket; other site 1093787009057 dimerization interface [polypeptide binding]; other site 1093787009058 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1093787009059 hydrophobic ligand binding site; other site 1093787009060 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1093787009061 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787009062 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1093787009063 substrate binding pocket [chemical binding]; other site 1093787009064 dimerization interface [polypeptide binding]; other site 1093787009065 SnoaL-like domain; Region: SnoaL_2; pfam12680 1093787009066 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1093787009067 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 1093787009068 tetramer interface [polypeptide binding]; other site 1093787009069 catalytic Zn binding site [ion binding]; other site 1093787009070 NADP binding site [chemical binding]; other site 1093787009071 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1093787009072 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1093787009073 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1093787009074 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787009075 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1093787009076 DNA binding site [nucleotide binding] 1093787009077 active site 1093787009078 Uncharacterized conserved protein [Function unknown]; Region: COG4336 1093787009079 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787009080 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787009081 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1093787009082 dimerization interface [polypeptide binding]; other site 1093787009083 benzoate transport; Region: 2A0115; TIGR00895 1093787009084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787009085 putative substrate translocation pore; other site 1093787009086 outer membrane porin, OprD family; Region: OprD; pfam03573 1093787009087 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1093787009088 putative active site [active] 1093787009089 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1093787009090 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1093787009091 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1093787009092 Predicted outer membrane protein [Function unknown]; Region: COG3652 1093787009093 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1093787009094 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1093787009095 PYR/PP interface [polypeptide binding]; other site 1093787009096 dimer interface [polypeptide binding]; other site 1093787009097 tetramer interface [polypeptide binding]; other site 1093787009098 TPP binding site [chemical binding]; other site 1093787009099 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1093787009100 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1093787009101 TPP-binding site [chemical binding]; other site 1093787009102 short chain dehydrogenase; Provisional; Region: PRK08267 1093787009103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787009104 NAD(P) binding site [chemical binding]; other site 1093787009105 active site 1093787009106 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1093787009107 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1093787009108 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1093787009109 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1093787009110 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1093787009111 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787009112 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1093787009113 FecR protein; Region: FecR; pfam04773 1093787009114 RNA polymerase sigma factor; Provisional; Region: PRK12525 1093787009115 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1093787009116 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1093787009117 DNA binding residues [nucleotide binding] 1093787009118 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1093787009119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1093787009120 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1093787009121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787009122 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1093787009123 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1093787009124 dimer interface [polypeptide binding]; other site 1093787009125 active site 1093787009126 non-prolyl cis peptide bond; other site 1093787009127 insertion regions; other site 1093787009128 Secretin and TonB N terminus short domain; Region: STN; smart00965 1093787009129 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1093787009130 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787009131 N-terminal plug; other site 1093787009132 ligand-binding site [chemical binding]; other site 1093787009133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1093787009134 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1093787009135 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1093787009136 inter-subunit interface; other site 1093787009137 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1093787009138 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1093787009139 active site 1093787009140 dimer interface [polypeptide binding]; other site 1093787009141 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1093787009142 Ligand Binding Site [chemical binding]; other site 1093787009143 Molecular Tunnel; other site 1093787009144 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1093787009145 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1093787009146 [2Fe-2S] cluster binding site [ion binding]; other site 1093787009147 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1093787009148 putative alpha subunit interface [polypeptide binding]; other site 1093787009149 putative active site [active] 1093787009150 putative substrate binding site [chemical binding]; other site 1093787009151 Fe binding site [ion binding]; other site 1093787009152 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1093787009153 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1093787009154 putative DNA binding site [nucleotide binding]; other site 1093787009155 putative Zn2+ binding site [ion binding]; other site 1093787009156 AsnC family; Region: AsnC_trans_reg; pfam01037 1093787009157 arylformamidase; Region: trp_arylform; TIGR03035 1093787009158 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 1093787009159 kynureninase; Region: kynureninase; TIGR01814 1093787009160 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1093787009161 catalytic residue [active] 1093787009162 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1093787009163 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1093787009164 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787009165 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787009166 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787009167 dimerization interface [polypeptide binding]; other site 1093787009168 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322 1093787009169 PAS domain S-box; Region: sensory_box; TIGR00229 1093787009170 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787009171 putative active site [active] 1093787009172 heme pocket [chemical binding]; other site 1093787009173 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787009174 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787009175 metal binding site [ion binding]; metal-binding site 1093787009176 active site 1093787009177 I-site; other site 1093787009178 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1093787009179 elongation factor G; Reviewed; Region: PRK00007 1093787009180 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1093787009181 G1 box; other site 1093787009182 putative GEF interaction site [polypeptide binding]; other site 1093787009183 GTP/Mg2+ binding site [chemical binding]; other site 1093787009184 Switch I region; other site 1093787009185 G2 box; other site 1093787009186 G3 box; other site 1093787009187 Switch II region; other site 1093787009188 G4 box; other site 1093787009189 G5 box; other site 1093787009190 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1093787009191 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1093787009192 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1093787009193 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1093787009194 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787009195 N-terminal plug; other site 1093787009196 ligand-binding site [chemical binding]; other site 1093787009197 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1093787009198 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1093787009199 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1093787009200 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1093787009201 MFS_1 like family; Region: MFS_1_like; pfam12832 1093787009202 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1093787009203 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1093787009204 motif II; other site 1093787009205 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1093787009206 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1093787009207 putative active site [active] 1093787009208 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 1093787009209 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1093787009210 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1093787009211 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 1093787009212 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1093787009213 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: PcoB; COG3667 1093787009214 Uncharacterized conserved protein [Function unknown]; Region: COG3673 1093787009215 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1093787009216 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1093787009217 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1093787009218 catalytic residue [active] 1093787009219 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1093787009220 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1093787009221 Walker A/P-loop; other site 1093787009222 ATP binding site [chemical binding]; other site 1093787009223 Q-loop/lid; other site 1093787009224 ABC transporter signature motif; other site 1093787009225 Walker B; other site 1093787009226 D-loop; other site 1093787009227 H-loop/switch region; other site 1093787009228 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1093787009229 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1093787009230 Walker A/P-loop; other site 1093787009231 ATP binding site [chemical binding]; other site 1093787009232 Q-loop/lid; other site 1093787009233 ABC transporter signature motif; other site 1093787009234 Walker B; other site 1093787009235 D-loop; other site 1093787009236 H-loop/switch region; other site 1093787009237 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1093787009238 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1093787009239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787009240 dimer interface [polypeptide binding]; other site 1093787009241 conserved gate region; other site 1093787009242 ABC-ATPase subunit interface; other site 1093787009243 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1093787009244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787009245 dimer interface [polypeptide binding]; other site 1093787009246 conserved gate region; other site 1093787009247 ABC-ATPase subunit interface; other site 1093787009248 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1093787009249 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1093787009250 Secretin and TonB N terminus short domain; Region: STN; smart00965 1093787009251 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787009252 N-terminal plug; other site 1093787009253 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1093787009254 ligand-binding site [chemical binding]; other site 1093787009255 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787009256 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787009257 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1093787009258 putative effector binding pocket; other site 1093787009259 dimerization interface [polypeptide binding]; other site 1093787009260 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1093787009261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787009262 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1093787009263 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787009264 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 1093787009265 dimerization interface [polypeptide binding]; other site 1093787009266 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1093787009267 active site clefts [active] 1093787009268 zinc binding site [ion binding]; other site 1093787009269 dimer interface [polypeptide binding]; other site 1093787009270 cyanate hydratase; Validated; Region: PRK02866 1093787009271 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1093787009272 oligomer interface [polypeptide binding]; other site 1093787009273 active site 1093787009274 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1093787009275 FecR protein; Region: FecR; pfam04773 1093787009276 RNA polymerase sigma factor; Provisional; Region: PRK12525 1093787009277 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1093787009278 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1093787009279 DNA binding residues [nucleotide binding] 1093787009280 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1093787009281 metal binding site [ion binding]; metal-binding site 1093787009282 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1093787009283 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1093787009284 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1093787009285 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1093787009286 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1093787009287 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787009288 Haemolytic domain; Region: Haemolytic; pfam01809 1093787009289 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 1093787009290 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1093787009291 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1093787009292 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1093787009293 probable active site [active] 1093787009294 serine/threonine transporter SstT; Provisional; Region: PRK13628 1093787009295 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1093787009296 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1093787009297 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1093787009298 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1093787009299 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1093787009300 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1093787009301 Predicted membrane protein [Function unknown]; Region: COG4392 1093787009302 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1093787009303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1093787009304 thiamine pyrophosphate protein; Validated; Region: PRK08199 1093787009305 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1093787009306 PYR/PP interface [polypeptide binding]; other site 1093787009307 dimer interface [polypeptide binding]; other site 1093787009308 TPP binding site [chemical binding]; other site 1093787009309 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1093787009310 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1093787009311 TPP-binding site [chemical binding]; other site 1093787009312 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1093787009313 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1093787009314 FAD binding pocket [chemical binding]; other site 1093787009315 FAD binding motif [chemical binding]; other site 1093787009316 phosphate binding motif [ion binding]; other site 1093787009317 NAD binding pocket [chemical binding]; other site 1093787009318 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1093787009319 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787009320 DNA-binding site [nucleotide binding]; DNA binding site 1093787009321 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1093787009322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787009323 homodimer interface [polypeptide binding]; other site 1093787009324 catalytic residue [active] 1093787009325 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547 1093787009326 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1093787009327 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1093787009328 putative DNA binding site [nucleotide binding]; other site 1093787009329 putative Zn2+ binding site [ion binding]; other site 1093787009330 AsnC family; Region: AsnC_trans_reg; pfam01037 1093787009331 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1093787009332 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1093787009333 glutathione reductase; Validated; Region: PRK06116 1093787009334 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1093787009335 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1093787009336 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1093787009337 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1093787009338 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1093787009339 active site 1093787009340 metal binding site [ion binding]; metal-binding site 1093787009341 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1093787009342 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1093787009343 active site 1093787009344 tetramer interface; other site 1093787009345 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1093787009346 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1093787009347 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1093787009348 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1093787009349 Protein of unknown function (DUF3203); Region: DUF3203; pfam11462 1093787009350 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787009351 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787009352 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 1093787009353 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787009354 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787009355 multidrug efflux protein; Reviewed; Region: PRK09577 1093787009356 Protein export membrane protein; Region: SecD_SecF; cl14618 1093787009357 SdiA-regulated; Region: SdiA-regulated; pfam06977 1093787009358 SdiA-regulated; Region: SdiA-regulated; cd09971 1093787009359 putative active site [active] 1093787009360 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 1093787009361 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1093787009362 DNA binding residues [nucleotide binding] 1093787009363 putative dimer interface [polypeptide binding]; other site 1093787009364 isovaleryl-CoA dehydrogenase; Region: PLN02519 1093787009365 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 1093787009366 substrate binding site [chemical binding]; other site 1093787009367 FAD binding site [chemical binding]; other site 1093787009368 catalytic base [active] 1093787009369 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1093787009370 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1093787009371 gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674 1093787009372 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1093787009373 substrate binding site [chemical binding]; other site 1093787009374 oxyanion hole (OAH) forming residues; other site 1093787009375 trimer interface [polypeptide binding]; other site 1093787009376 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1093787009377 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1093787009378 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1093787009379 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1093787009380 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1093787009381 carboxyltransferase (CT) interaction site; other site 1093787009382 biotinylation site [posttranslational modification]; other site 1093787009383 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1093787009384 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1093787009385 active site 1093787009386 catalytic residues [active] 1093787009387 metal binding site [ion binding]; metal-binding site 1093787009388 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1093787009389 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1093787009390 Bacterial transcriptional regulator; Region: IclR; pfam01614 1093787009391 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 1093787009392 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 1093787009393 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1093787009394 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1093787009395 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1093787009396 C-terminal domain interface [polypeptide binding]; other site 1093787009397 GSH binding site (G-site) [chemical binding]; other site 1093787009398 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1093787009399 putative dimer interface [polypeptide binding]; other site 1093787009400 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1093787009401 dimer interface [polypeptide binding]; other site 1093787009402 N-terminal domain interface [polypeptide binding]; other site 1093787009403 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1093787009404 benzoate transport; Region: 2A0115; TIGR00895 1093787009405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787009406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787009407 PAS domain; Region: PAS; smart00091 1093787009408 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1093787009409 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787009410 Walker B motif; other site 1093787009411 arginine finger; other site 1093787009412 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1093787009413 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1093787009414 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1093787009415 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1093787009416 NAD binding site [chemical binding]; other site 1093787009417 homotetramer interface [polypeptide binding]; other site 1093787009418 homodimer interface [polypeptide binding]; other site 1093787009419 substrate binding site [chemical binding]; other site 1093787009420 active site 1093787009421 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1093787009422 acetyl-CoA acetyltransferase; Provisional; Region: PRK05656 1093787009423 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1093787009424 dimer interface [polypeptide binding]; other site 1093787009425 active site 1093787009426 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1093787009427 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1093787009428 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787009429 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787009430 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1093787009431 putative dimerization interface [polypeptide binding]; other site 1093787009432 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1093787009433 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 1093787009434 acyl-activating enzyme (AAE) consensus motif; other site 1093787009435 putative AMP binding site [chemical binding]; other site 1093787009436 putative active site [active] 1093787009437 putative CoA binding site [chemical binding]; other site 1093787009438 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1093787009439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1093787009440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 1093787009441 major facilitator superfamily transporter; Provisional; Region: PRK05122 1093787009442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787009443 putative substrate translocation pore; other site 1093787009444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1093787009445 PAS domain S-box; Region: sensory_box; TIGR00229 1093787009446 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1093787009447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787009448 dimer interface [polypeptide binding]; other site 1093787009449 phosphorylation site [posttranslational modification] 1093787009450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787009451 ATP binding site [chemical binding]; other site 1093787009452 G-X-G motif; other site 1093787009453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787009454 active site 1093787009455 phosphorylation site [posttranslational modification] 1093787009456 intermolecular recognition site; other site 1093787009457 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 1093787009458 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1093787009459 putative active site [active] 1093787009460 metal binding site [ion binding]; metal-binding site 1093787009461 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1093787009462 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1093787009463 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 1093787009464 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1093787009465 FeS/SAM binding site; other site 1093787009466 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1093787009467 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 1093787009468 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 1093787009469 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 1093787009470 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 1093787009471 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 1093787009472 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1093787009473 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1093787009474 NAD(P) binding site [chemical binding]; other site 1093787009475 catalytic residues [active] 1093787009476 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1093787009477 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1093787009478 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1093787009479 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 1093787009480 dimer interface [polypeptide binding]; other site 1093787009481 Trp docking motif [polypeptide binding]; other site 1093787009482 active site 1093787009483 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1093787009484 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1093787009485 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1093787009486 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1093787009487 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1093787009488 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1093787009489 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1093787009490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787009491 active site 1093787009492 phosphorylation site [posttranslational modification] 1093787009493 intermolecular recognition site; other site 1093787009494 dimerization interface [polypeptide binding]; other site 1093787009495 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787009496 DNA binding residues [nucleotide binding] 1093787009497 dimerization interface [polypeptide binding]; other site 1093787009498 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1093787009499 Histidine kinase; Region: HisKA_3; pfam07730 1093787009500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787009501 ATP binding site [chemical binding]; other site 1093787009502 Mg2+ binding site [ion binding]; other site 1093787009503 G-X-G motif; other site 1093787009504 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1093787009505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787009506 active site 1093787009507 phosphorylation site [posttranslational modification] 1093787009508 intermolecular recognition site; other site 1093787009509 dimerization interface [polypeptide binding]; other site 1093787009510 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787009511 DNA binding residues [nucleotide binding] 1093787009512 dimerization interface [polypeptide binding]; other site 1093787009513 PAS fold; Region: PAS_7; pfam12860 1093787009514 PAS fold; Region: PAS_7; pfam12860 1093787009515 PAS fold; Region: PAS_4; pfam08448 1093787009516 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1093787009517 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787009518 dimer interface [polypeptide binding]; other site 1093787009519 phosphorylation site [posttranslational modification] 1093787009520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787009521 ATP binding site [chemical binding]; other site 1093787009522 Mg2+ binding site [ion binding]; other site 1093787009523 G-X-G motif; other site 1093787009524 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1093787009525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787009526 active site 1093787009527 phosphorylation site [posttranslational modification] 1093787009528 intermolecular recognition site; other site 1093787009529 dimerization interface [polypeptide binding]; other site 1093787009530 Uncharacterized conserved protein [Function unknown]; Region: COG3287 1093787009531 FIST N domain; Region: FIST; pfam08495 1093787009532 FIST C domain; Region: FIST_C; pfam10442 1093787009533 Gram-negative porin; Region: Porin_4; pfam13609 1093787009534 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 1093787009535 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1093787009536 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1093787009537 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1093787009538 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1093787009539 Sulfatase; Region: Sulfatase; pfam00884 1093787009540 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1093787009541 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 1093787009542 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1093787009543 putative substrate binding pocket [chemical binding]; other site 1093787009544 trimer interface [polypeptide binding]; other site 1093787009545 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1093787009546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787009547 Walker A/P-loop; other site 1093787009548 ATP binding site [chemical binding]; other site 1093787009549 Q-loop/lid; other site 1093787009550 ABC transporter signature motif; other site 1093787009551 Walker B; other site 1093787009552 D-loop; other site 1093787009553 H-loop/switch region; other site 1093787009554 ABC transporter; Region: ABC_tran_2; pfam12848 1093787009555 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1093787009556 azoreductase; Reviewed; Region: PRK00170 1093787009557 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1093787009558 LysR family transcriptional regulator; Provisional; Region: PRK14997 1093787009559 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787009560 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787009561 dimerization interface [polypeptide binding]; other site 1093787009562 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1093787009563 DNA-binding site [nucleotide binding]; DNA binding site 1093787009564 RNA-binding motif; other site 1093787009565 Predicted membrane protein [Function unknown]; Region: COG3326 1093787009566 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1093787009567 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1093787009568 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1093787009569 AAA domain; Region: AAA_28; pfam13521 1093787009570 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 1093787009571 putative active site [active] 1093787009572 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1093787009573 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1093787009574 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1093787009575 substrate binding site [chemical binding]; other site 1093787009576 dimer interface [polypeptide binding]; other site 1093787009577 ATP binding site [chemical binding]; other site 1093787009578 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1093787009579 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1093787009580 DNA binding site [nucleotide binding] 1093787009581 domain linker motif; other site 1093787009582 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1093787009583 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1093787009584 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1093787009585 TM-ABC transporter signature motif; other site 1093787009586 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1093787009587 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1093787009588 Walker A/P-loop; other site 1093787009589 ATP binding site [chemical binding]; other site 1093787009590 Q-loop/lid; other site 1093787009591 ABC transporter signature motif; other site 1093787009592 Walker B; other site 1093787009593 D-loop; other site 1093787009594 H-loop/switch region; other site 1093787009595 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1093787009596 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1093787009597 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1093787009598 ligand binding site [chemical binding]; other site 1093787009599 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1093787009600 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787009601 Walker A motif; other site 1093787009602 ATP binding site [chemical binding]; other site 1093787009603 Walker B motif; other site 1093787009604 arginine finger; other site 1093787009605 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1093787009606 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 1093787009607 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 1093787009608 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1093787009609 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1093787009610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787009611 Coenzyme A binding pocket [chemical binding]; other site 1093787009612 Peptidase_C39 like family; Region: DUF3335; pfam11814 1093787009613 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 1093787009614 putative heme binding pocket [chemical binding]; other site 1093787009615 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 1093787009616 metal binding site [ion binding]; metal-binding site 1093787009617 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1093787009618 Domain of unknown function (DUF4354); Region: DUF4354; pfam14263 1093787009619 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787009620 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1093787009621 putative active site [active] 1093787009622 heme pocket [chemical binding]; other site 1093787009623 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787009624 putative active site [active] 1093787009625 heme pocket [chemical binding]; other site 1093787009626 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1093787009627 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787009628 dimer interface [polypeptide binding]; other site 1093787009629 putative CheW interface [polypeptide binding]; other site 1093787009630 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1093787009631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1093787009632 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1093787009633 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1093787009634 THF binding site; other site 1093787009635 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1093787009636 substrate binding site [chemical binding]; other site 1093787009637 THF binding site; other site 1093787009638 zinc-binding site [ion binding]; other site 1093787009639 YcaO domain protein; Region: TIGR03549 1093787009640 OsmC-like protein; Region: OsmC; pfam02566 1093787009641 YcaO-like family; Region: YcaO; pfam02624 1093787009642 Uncharacterized conserved protein [Function unknown]; Region: COG4744 1093787009643 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1093787009644 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1093787009645 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1093787009646 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1093787009647 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 1093787009648 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787009649 N-terminal plug; other site 1093787009650 ligand-binding site [chemical binding]; other site 1093787009651 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1093787009652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787009653 S-adenosylmethionine binding site [chemical binding]; other site 1093787009654 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 1093787009655 ATP cone domain; Region: ATP-cone; pfam03477 1093787009656 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1093787009657 effector binding site; other site 1093787009658 active site 1093787009659 Zn binding site [ion binding]; other site 1093787009660 glycine loop; other site 1093787009661 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 1093787009662 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 1093787009663 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1093787009664 FeS/SAM binding site; other site 1093787009665 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1093787009666 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1093787009667 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1093787009668 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1093787009669 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1093787009670 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1093787009671 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1093787009672 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1093787009673 RNA polymerase sigma factor; Provisional; Region: PRK12528 1093787009674 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1093787009675 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1093787009676 DNA binding residues [nucleotide binding] 1093787009677 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1093787009678 FecR protein; Region: FecR; pfam04773 1093787009679 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1093787009680 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787009681 N-terminal plug; other site 1093787009682 ligand-binding site [chemical binding]; other site 1093787009683 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1093787009684 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1093787009685 RNA polymerase Rpb5, C-terminal domain; Region: RNA_pol_Rpb5_C; cl00883 1093787009686 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1093787009687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787009688 putative substrate translocation pore; other site 1093787009689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1093787009690 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1093787009691 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1093787009692 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1093787009693 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 1093787009694 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1093787009695 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1093787009696 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1093787009697 glutamine binding [chemical binding]; other site 1093787009698 catalytic triad [active] 1093787009699 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1093787009700 hydrophobic substrate binding pocket; other site 1093787009701 Isochorismatase family; Region: Isochorismatase; pfam00857 1093787009702 active site 1093787009703 conserved cis-peptide bond; other site 1093787009704 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 1093787009705 Phenazine biosynthesis protein A/B; Region: PHZA_PHZB; pfam03284 1093787009706 Phenazine biosynthesis protein A/B; Region: PHZA_PHZB; pfam03284 1093787009707 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1093787009708 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787009709 DNA binding residues [nucleotide binding] 1093787009710 dimerization interface [polypeptide binding]; other site 1093787009711 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1093787009712 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1093787009713 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1093787009714 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1093787009715 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1093787009716 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1093787009717 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1093787009718 active site 1093787009719 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1093787009720 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1093787009721 putative C-terminal domain interface [polypeptide binding]; other site 1093787009722 putative GSH binding site (G-site) [chemical binding]; other site 1093787009723 putative dimer interface [polypeptide binding]; other site 1093787009724 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1093787009725 putative N-terminal domain interface [polypeptide binding]; other site 1093787009726 putative dimer interface [polypeptide binding]; other site 1093787009727 putative substrate binding pocket (H-site) [chemical binding]; other site 1093787009728 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1093787009729 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1093787009730 dimer interface [polypeptide binding]; other site 1093787009731 active site 1093787009732 catalytic residue [active] 1093787009733 DNA polymerase II; Reviewed; Region: PRK05762 1093787009734 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1093787009735 active site 1093787009736 catalytic site [active] 1093787009737 substrate binding site [chemical binding]; other site 1093787009738 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1093787009739 active site 1093787009740 metal-binding site 1093787009741 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787009742 Coenzyme A binding pocket [chemical binding]; other site 1093787009743 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1093787009744 sequence-specific DNA binding site [nucleotide binding]; other site 1093787009745 salt bridge; other site 1093787009746 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1093787009747 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1093787009748 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1093787009749 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1093787009750 catalytic loop [active] 1093787009751 iron binding site [ion binding]; other site 1093787009752 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1093787009753 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1093787009754 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1093787009755 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1093787009756 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1093787009757 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1093787009758 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1093787009759 non-specific DNA binding site [nucleotide binding]; other site 1093787009760 salt bridge; other site 1093787009761 sequence-specific DNA binding site [nucleotide binding]; other site 1093787009762 HD domain; Region: HD_3; pfam13023 1093787009763 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1093787009764 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787009765 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787009766 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1093787009767 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 1093787009768 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1093787009769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787009770 Walker A/P-loop; other site 1093787009771 ATP binding site [chemical binding]; other site 1093787009772 Q-loop/lid; other site 1093787009773 ABC transporter signature motif; other site 1093787009774 Walker B; other site 1093787009775 D-loop; other site 1093787009776 H-loop/switch region; other site 1093787009777 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1093787009778 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1093787009779 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1093787009780 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1093787009781 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 1093787009782 Cl binding site [ion binding]; other site 1093787009783 oligomer interface [polypeptide binding]; other site 1093787009784 EcsC protein family; Region: EcsC; pfam12787 1093787009785 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1093787009786 Peptidase family M23; Region: Peptidase_M23; pfam01551 1093787009787 acyl carrier protein; Provisional; Region: acpP; PRK00982 1093787009788 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 1093787009789 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1093787009790 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1093787009791 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1093787009792 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1093787009793 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1093787009794 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1093787009795 DEAD_2; Region: DEAD_2; pfam06733 1093787009796 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1093787009797 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 1093787009798 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1093787009799 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787009800 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1093787009801 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1093787009802 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1093787009803 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1093787009804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787009805 dimer interface [polypeptide binding]; other site 1093787009806 conserved gate region; other site 1093787009807 putative PBP binding loops; other site 1093787009808 ABC-ATPase subunit interface; other site 1093787009809 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 1093787009810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787009811 Walker A/P-loop; other site 1093787009812 ATP binding site [chemical binding]; other site 1093787009813 Q-loop/lid; other site 1093787009814 ABC transporter signature motif; other site 1093787009815 Walker B; other site 1093787009816 D-loop; other site 1093787009817 H-loop/switch region; other site 1093787009818 TOBE domain; Region: TOBE; cl01440 1093787009819 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1093787009820 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1093787009821 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787009822 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787009823 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 1093787009824 putative effector binding pocket; other site 1093787009825 dimerization interface [polypeptide binding]; other site 1093787009826 Streptomycin 6-kinase [Defense mechanisms]; Region: StrB; COG3570 1093787009827 Protein of unknown function (DUF808); Region: DUF808; pfam05661 1093787009828 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1093787009829 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1093787009830 Low-spin heme binding site [chemical binding]; other site 1093787009831 Putative water exit pathway; other site 1093787009832 Binuclear center (active site) [active] 1093787009833 Putative proton exit pathway; other site 1093787009834 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 1093787009835 HPP family; Region: HPP; pfam04982 1093787009836 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 1093787009837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787009838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787009839 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1093787009840 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787009841 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787009842 metal binding site [ion binding]; metal-binding site 1093787009843 active site 1093787009844 I-site; other site 1093787009845 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1093787009846 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1093787009847 conserved cys residue [active] 1093787009848 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787009849 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787009850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 1093787009851 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 1093787009852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787009853 putative substrate translocation pore; other site 1093787009854 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1093787009855 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 1093787009856 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1093787009857 Cytochrome c; Region: Cytochrom_C; cl11414 1093787009858 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 1093787009859 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1093787009860 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1093787009861 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1093787009862 substrate binding pocket [chemical binding]; other site 1093787009863 dimer interface [polypeptide binding]; other site 1093787009864 inhibitor binding site; inhibition site 1093787009865 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1093787009866 B12 binding site [chemical binding]; other site 1093787009867 cobalt ligand [ion binding]; other site 1093787009868 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1093787009869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3171 1093787009870 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 1093787009871 putative deacylase active site [active] 1093787009872 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 1093787009873 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14464 1093787009874 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 1093787009875 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1093787009876 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1093787009877 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1093787009878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 1093787009879 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787009880 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787009881 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1093787009882 CoenzymeA binding site [chemical binding]; other site 1093787009883 subunit interaction site [polypeptide binding]; other site 1093787009884 PHB binding site; other site 1093787009885 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1093787009886 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1093787009887 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 1093787009888 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1093787009889 NADP binding site [chemical binding]; other site 1093787009890 dimer interface [polypeptide binding]; other site 1093787009891 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1093787009892 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1093787009893 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1093787009894 tandem repeat interface [polypeptide binding]; other site 1093787009895 oligomer interface [polypeptide binding]; other site 1093787009896 active site residues [active] 1093787009897 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1093787009898 catalytic core [active] 1093787009899 Putative sterol carrier protein [Lipid metabolism]; Region: COG3255 1093787009900 Phosphotransferase enzyme family; Region: APH; pfam01636 1093787009901 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1093787009902 putative active site [active] 1093787009903 putative substrate binding site [chemical binding]; other site 1093787009904 ATP binding site [chemical binding]; other site 1093787009905 short chain dehydrogenase; Provisional; Region: PRK07035 1093787009906 classical (c) SDRs; Region: SDR_c; cd05233 1093787009907 NAD(P) binding site [chemical binding]; other site 1093787009908 active site 1093787009909 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1093787009910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787009911 NAD(P) binding site [chemical binding]; other site 1093787009912 active site 1093787009913 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1093787009914 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787009915 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1093787009916 dimerization interface [polypeptide binding]; other site 1093787009917 substrate binding pocket [chemical binding]; other site 1093787009918 hypothetical protein; Provisional; Region: PRK10621 1093787009919 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1093787009920 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1093787009921 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1093787009922 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1093787009923 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1093787009924 putative NADH binding site [chemical binding]; other site 1093787009925 putative active site [active] 1093787009926 nudix motif; other site 1093787009927 putative metal binding site [ion binding]; other site 1093787009928 enoyl-CoA hydratase; Provisional; Region: PRK06142 1093787009929 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1093787009930 substrate binding site [chemical binding]; other site 1093787009931 oxyanion hole (OAH) forming residues; other site 1093787009932 trimer interface [polypeptide binding]; other site 1093787009933 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 1093787009934 arginine:agmatin antiporter; Provisional; Region: PRK10644 1093787009935 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1093787009936 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1093787009937 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1093787009938 homodimer interface [polypeptide binding]; other site 1093787009939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787009940 catalytic residue [active] 1093787009941 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1093787009942 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1093787009943 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1093787009944 active site 1093787009945 catalytic site [active] 1093787009946 substrate binding site [chemical binding]; other site 1093787009947 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1093787009948 RNA/DNA hybrid binding site [nucleotide binding]; other site 1093787009949 active site 1093787009950 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1093787009951 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1093787009952 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1093787009953 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1093787009954 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1093787009955 catalytic residue [active] 1093787009956 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1093787009957 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1093787009958 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1093787009959 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1093787009960 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1093787009961 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1093787009962 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1093787009963 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1093787009964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787009965 dimer interface [polypeptide binding]; other site 1093787009966 conserved gate region; other site 1093787009967 putative PBP binding loops; other site 1093787009968 ABC-ATPase subunit interface; other site 1093787009969 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1093787009970 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1093787009971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787009972 dimer interface [polypeptide binding]; other site 1093787009973 conserved gate region; other site 1093787009974 putative PBP binding loops; other site 1093787009975 ABC-ATPase subunit interface; other site 1093787009976 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1093787009977 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1093787009978 Walker A/P-loop; other site 1093787009979 ATP binding site [chemical binding]; other site 1093787009980 Q-loop/lid; other site 1093787009981 ABC transporter signature motif; other site 1093787009982 Walker B; other site 1093787009983 D-loop; other site 1093787009984 H-loop/switch region; other site 1093787009985 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1093787009986 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1093787009987 Walker A/P-loop; other site 1093787009988 ATP binding site [chemical binding]; other site 1093787009989 Q-loop/lid; other site 1093787009990 ABC transporter signature motif; other site 1093787009991 Walker B; other site 1093787009992 D-loop; other site 1093787009993 H-loop/switch region; other site 1093787009994 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1093787009995 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1093787009996 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1093787009997 NAD binding site [chemical binding]; other site 1093787009998 homotetramer interface [polypeptide binding]; other site 1093787009999 homodimer interface [polypeptide binding]; other site 1093787010000 substrate binding site [chemical binding]; other site 1093787010001 active site 1093787010002 periplasmic folding chaperone; Provisional; Region: PRK10788 1093787010003 SurA N-terminal domain; Region: SurA_N_3; pfam13624 1093787010004 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1093787010005 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1093787010006 IHF dimer interface [polypeptide binding]; other site 1093787010007 IHF - DNA interface [nucleotide binding]; other site 1093787010008 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1093787010009 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1093787010010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787010011 Walker A motif; other site 1093787010012 ATP binding site [chemical binding]; other site 1093787010013 Walker B motif; other site 1093787010014 arginine finger; other site 1093787010015 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1093787010016 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1093787010017 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1093787010018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787010019 Walker A motif; other site 1093787010020 ATP binding site [chemical binding]; other site 1093787010021 Walker B motif; other site 1093787010022 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1093787010023 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1093787010024 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1093787010025 oligomer interface [polypeptide binding]; other site 1093787010026 active site residues [active] 1093787010027 trigger factor; Provisional; Region: tig; PRK01490 1093787010028 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1093787010029 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1093787010030 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1093787010031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787010032 active site 1093787010033 phosphorylation site [posttranslational modification] 1093787010034 intermolecular recognition site; other site 1093787010035 dimerization interface [polypeptide binding]; other site 1093787010036 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787010037 DNA binding site [nucleotide binding] 1093787010038 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787010039 dimerization interface [polypeptide binding]; other site 1093787010040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787010041 dimer interface [polypeptide binding]; other site 1093787010042 phosphorylation site [posttranslational modification] 1093787010043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787010044 ATP binding site [chemical binding]; other site 1093787010045 Mg2+ binding site [ion binding]; other site 1093787010046 G-X-G motif; other site 1093787010047 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1093787010048 Beta-lactamase; Region: Beta-lactamase; pfam00144 1093787010049 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1093787010050 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1093787010051 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1093787010052 homodimer interface [polypeptide binding]; other site 1093787010053 NADP binding site [chemical binding]; other site 1093787010054 substrate binding site [chemical binding]; other site 1093787010055 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1093787010056 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1093787010057 active site 1093787010058 HIGH motif; other site 1093787010059 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1093787010060 KMSKS motif; other site 1093787010061 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1093787010062 tRNA binding surface [nucleotide binding]; other site 1093787010063 anticodon binding site; other site 1093787010064 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1093787010065 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1093787010066 active site 1093787010067 HIGH motif; other site 1093787010068 nucleotide binding site [chemical binding]; other site 1093787010069 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1093787010070 KMSKS motif; other site 1093787010071 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1093787010072 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1093787010073 substrate binding site [chemical binding]; other site 1093787010074 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1093787010075 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1093787010076 putative active site [active] 1093787010077 putative metal binding site [ion binding]; other site 1093787010078 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1093787010079 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1093787010080 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1093787010081 active site 1093787010082 dinuclear metal binding site [ion binding]; other site 1093787010083 dimerization interface [polypeptide binding]; other site 1093787010084 universal stress protein UspE; Provisional; Region: PRK11175 1093787010085 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1093787010086 Ligand Binding Site [chemical binding]; other site 1093787010087 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1093787010088 Ligand Binding Site [chemical binding]; other site 1093787010089 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1093787010090 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1093787010091 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1093787010092 substrate binding site [chemical binding]; other site 1093787010093 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1093787010094 substrate binding site [chemical binding]; other site 1093787010095 ligand binding site [chemical binding]; other site 1093787010096 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1093787010097 NMT1-like family; Region: NMT1_2; pfam13379 1093787010098 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1093787010099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787010100 active site 1093787010101 phosphorylation site [posttranslational modification] 1093787010102 intermolecular recognition site; other site 1093787010103 dimerization interface [polypeptide binding]; other site 1093787010104 ANTAR domain; Region: ANTAR; pfam03861 1093787010105 Alginate lyase; Region: Alginate_lyase2; pfam08787 1093787010106 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1093787010107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787010108 putative substrate translocation pore; other site 1093787010109 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1093787010110 active site 1093787010111 Protein kinase domain; Region: Pkinase; pfam00069 1093787010112 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1093787010113 active site 1093787010114 ATP binding site [chemical binding]; other site 1093787010115 substrate binding site [chemical binding]; other site 1093787010116 activation loop (A-loop); other site 1093787010117 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1093787010118 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1093787010119 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1093787010120 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1093787010121 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1093787010122 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1093787010123 [2Fe-2S] cluster binding site [ion binding]; other site 1093787010124 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1093787010125 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1093787010126 [4Fe-4S] binding site [ion binding]; other site 1093787010127 molybdopterin cofactor binding site; other site 1093787010128 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1093787010129 molybdopterin cofactor binding site; other site 1093787010130 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1093787010131 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1093787010132 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1093787010133 active site 1093787010134 SAM binding site [chemical binding]; other site 1093787010135 homodimer interface [polypeptide binding]; other site 1093787010136 OprF membrane domain; Region: OprF; pfam05736 1093787010137 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1093787010138 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1093787010139 ligand binding site [chemical binding]; other site 1093787010140 RNA polymerase sigma factor SigX; Reviewed; Region: PRK09640 1093787010141 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1093787010142 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1093787010143 DNA binding residues [nucleotide binding] 1093787010144 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1093787010145 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1093787010146 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1093787010147 Cl binding site [ion binding]; other site 1093787010148 oligomer interface [polypeptide binding]; other site 1093787010149 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1093787010150 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1093787010151 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1093787010152 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1093787010153 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1093787010154 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1093787010155 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1093787010156 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1093787010157 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 1093787010158 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 1093787010159 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 1093787010160 Maltose operon periplasmic protein precursor (MalM); Region: MalM; pfam07148 1093787010161 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 1093787010162 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1093787010163 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 1093787010164 putative active site [active] 1093787010165 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1093787010166 AAA ATPase domain; Region: AAA_16; pfam13191 1093787010167 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787010168 DNA binding residues [nucleotide binding] 1093787010169 dimerization interface [polypeptide binding]; other site 1093787010170 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1093787010171 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787010172 DNA binding residues [nucleotide binding] 1093787010173 dimerization interface [polypeptide binding]; other site 1093787010174 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1093787010175 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 1093787010176 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1093787010177 phosphoserine phosphatase; Provisional; Region: thrH; PRK13582 1093787010178 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1093787010179 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1093787010180 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1093787010181 Active Sites [active] 1093787010182 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1093787010183 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787010184 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1093787010185 substrate binding site [chemical binding]; other site 1093787010186 dimerization interface [polypeptide binding]; other site 1093787010187 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1093787010188 Ligand Binding Site [chemical binding]; other site 1093787010189 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 1093787010190 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1093787010191 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1093787010192 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1093787010193 catalytic residues [active] 1093787010194 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1093787010195 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1093787010196 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787010197 Coenzyme A binding pocket [chemical binding]; other site 1093787010198 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1093787010199 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1093787010200 substrate binding site [chemical binding]; other site 1093787010201 oxyanion hole (OAH) forming residues; other site 1093787010202 trimer interface [polypeptide binding]; other site 1093787010203 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1093787010204 ADP-ribose binding site [chemical binding]; other site 1093787010205 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1093787010206 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1093787010207 catalytic triad [active] 1093787010208 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 1093787010209 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1093787010210 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1093787010211 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1093787010212 active site 1093787010213 catalytic tetrad [active] 1093787010214 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787010215 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787010216 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1093787010217 putative effector binding pocket; other site 1093787010218 putative dimerization interface [polypeptide binding]; other site 1093787010219 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1093787010220 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1093787010221 substrate binding site [chemical binding]; other site 1093787010222 oxyanion hole (OAH) forming residues; other site 1093787010223 trimer interface [polypeptide binding]; other site 1093787010224 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1093787010225 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1093787010226 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1093787010227 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1093787010228 dimer interface [polypeptide binding]; other site 1093787010229 active site 1093787010230 Predicted permeases [General function prediction only]; Region: COG0679 1093787010231 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1093787010232 Cytochrome c; Region: Cytochrom_C; pfam00034 1093787010233 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 1093787010234 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 1093787010235 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1093787010236 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1093787010237 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1093787010238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1093787010239 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1093787010240 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1093787010241 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1093787010242 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1093787010243 catalytic triad [active] 1093787010244 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1093787010245 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1093787010246 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1093787010247 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1093787010248 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787010249 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787010250 metal binding site [ion binding]; metal-binding site 1093787010251 active site 1093787010252 I-site; other site 1093787010253 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1093787010254 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1093787010255 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1093787010256 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1093787010257 Switch II region; other site 1093787010258 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1093787010259 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 1093787010260 Flagellar assembly protein FliH; Region: FliH; pfam02108 1093787010261 YOP proteins translocation protein K (YscK); Region: YscK; pfam06578 1093787010262 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 1093787010263 type III secretion apparatus protein, YscI/HrpB, C-terminal domain; Region: yscI_hrpB_dom; TIGR02497 1093787010264 YopR Core; Region: YopR_core; cl07585 1093787010265 Bacterial type II secretion system chaperone protein (type_III_yscG); Region: Type_III_YscG; pfam09477 1093787010266 Type III secretion needle MxiH like; Region: MxiH; cl09641 1093787010267 Protein of unknown function (DUF1895); Region: DUF1895; cl07553 1093787010268 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 1093787010269 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 1093787010270 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1093787010271 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1093787010272 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1093787010273 type III secretion system chaperone, YscB family; Region: type_III_yscB; TIGR02513 1093787010274 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 1093787010275 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1093787010276 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787010277 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787010278 type III secretion system chaperone YscW; Region: YscW; TIGR02567 1093787010279 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 1093787010280 YopD protein; Region: YopD; pfam05844 1093787010281 Uncharacterized conserved protein [Function unknown]; Region: COG5613 1093787010282 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 1093787010283 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1093787010284 binding surface 1093787010285 TPR motif; other site 1093787010286 V antigen (LcrV) protein; Region: LcrV; pfam04792 1093787010287 LcrG protein; Region: LcrG; cl06311 1093787010288 type III secretion system regulator LcrR; Region: LcrR; TIGR02572 1093787010289 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 1093787010290 FHIPEP family; Region: FHIPEP; pfam00771 1093787010291 type III secretion protein, YscX family; Region: type_III_YscX; TIGR02502 1093787010292 type III secretion chaperone SycN; Region: type_III_SycN; TIGR02503 1093787010293 TyeA; Region: TyeA; pfam09059 1093787010294 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 1093787010295 type III secretion system ATPase; Provisional; Region: PRK06936 1093787010296 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1093787010297 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1093787010298 Walker A motif/ATP binding site; other site 1093787010299 Walker B motif; other site 1093787010300 Type III secretion protein YscO; Region: YscO; pfam07321 1093787010301 type III secretion system needle length determinant; Region: type_III_yscP; TIGR02514 1093787010302 type III secretion system protein; Validated; Region: PRK06933 1093787010303 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1093787010304 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 1093787010305 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 1093787010306 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 1093787010307 Type III secretory pathway, component EscU [Intracellular trafficking and secretion]; Region: EscU; COG4792 1093787010308 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1093787010309 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1093787010310 Sulfatase; Region: Sulfatase; pfam00884 1093787010311 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1093787010312 Strictosidine synthase; Region: Str_synth; pfam03088 1093787010313 spermidine synthase; Provisional; Region: PRK00811 1093787010314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787010315 S-adenosylmethionine binding site [chemical binding]; other site 1093787010316 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1093787010317 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1093787010318 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1093787010319 minor groove reading motif; other site 1093787010320 helix-hairpin-helix signature motif; other site 1093787010321 substrate binding pocket [chemical binding]; other site 1093787010322 active site 1093787010323 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 1093787010324 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1093787010325 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1093787010326 Cupin domain; Region: Cupin_2; cl17218 1093787010327 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 1093787010328 intersubunit interface [polypeptide binding]; other site 1093787010329 active site 1093787010330 Zn2+ binding site [ion binding]; other site 1093787010331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787010332 putative substrate translocation pore; other site 1093787010333 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1093787010334 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1093787010335 Tetramer interface [polypeptide binding]; other site 1093787010336 active site 1093787010337 FMN-binding site [chemical binding]; other site 1093787010338 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1093787010339 HemK family putative methylases; Region: hemK_fam; TIGR00536 1093787010340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787010341 S-adenosylmethionine binding site [chemical binding]; other site 1093787010342 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1093787010343 Isochorismatase family; Region: Isochorismatase; pfam00857 1093787010344 catalytic triad [active] 1093787010345 conserved cis-peptide bond; other site 1093787010346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1093787010347 Smr domain; Region: Smr; pfam01713 1093787010348 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1093787010349 homodecamer interface [polypeptide binding]; other site 1093787010350 GTP cyclohydrolase I; Provisional; Region: PLN03044 1093787010351 active site 1093787010352 putative catalytic site residues [active] 1093787010353 zinc binding site [ion binding]; other site 1093787010354 GTP-CH-I/GFRP interaction surface; other site 1093787010355 Hemerythrin; Region: Hemerythrin; cd12107 1093787010356 Fe binding site [ion binding]; other site 1093787010357 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1093787010358 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1093787010359 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1093787010360 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1093787010361 active site 1093787010362 ATP binding site [chemical binding]; other site 1093787010363 substrate binding site [chemical binding]; other site 1093787010364 activation loop (A-loop); other site 1093787010365 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1093787010366 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1093787010367 Protein phosphatase 2C; Region: PP2C; pfam00481 1093787010368 active site 1093787010369 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1093787010370 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1093787010371 G1 box; other site 1093787010372 GTP/Mg2+ binding site [chemical binding]; other site 1093787010373 G2 box; other site 1093787010374 Switch I region; other site 1093787010375 G3 box; other site 1093787010376 Switch II region; other site 1093787010377 G4 box; other site 1093787010378 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1093787010379 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1093787010380 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 1093787010381 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 1093787010382 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1093787010383 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 1093787010384 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 1093787010385 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1093787010386 phosphopeptide binding site; other site 1093787010387 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 1093787010388 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1093787010389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787010390 Walker A motif; other site 1093787010391 ATP binding site [chemical binding]; other site 1093787010392 Walker B motif; other site 1093787010393 arginine finger; other site 1093787010394 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1093787010395 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1093787010396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787010397 Walker A motif; other site 1093787010398 ATP binding site [chemical binding]; other site 1093787010399 Walker B motif; other site 1093787010400 arginine finger; other site 1093787010401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787010402 Walker A motif; other site 1093787010403 ATP binding site [chemical binding]; other site 1093787010404 Walker B motif; other site 1093787010405 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1093787010406 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 1093787010407 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1093787010408 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1093787010409 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1093787010410 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1093787010411 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1093787010412 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1093787010413 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 1093787010414 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1093787010415 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 1093787010416 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1093787010417 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1093787010418 putative C-terminal domain interface [polypeptide binding]; other site 1093787010419 putative GSH binding site (G-site) [chemical binding]; other site 1093787010420 putative dimer interface [polypeptide binding]; other site 1093787010421 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1093787010422 N-terminal domain interface [polypeptide binding]; other site 1093787010423 dimer interface [polypeptide binding]; other site 1093787010424 substrate binding pocket (H-site) [chemical binding]; other site 1093787010425 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1093787010426 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1093787010427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787010428 homodimer interface [polypeptide binding]; other site 1093787010429 catalytic residue [active] 1093787010430 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1093787010431 MarR family; Region: MarR_2; pfam12802 1093787010432 benzoate transporter; Region: benE; TIGR00843 1093787010433 Benzoate membrane transport protein; Region: BenE; pfam03594 1093787010434 bile acid transporter; Region: bass; TIGR00841 1093787010435 Sodium Bile acid symporter family; Region: SBF; cl17470 1093787010436 short chain dehydrogenase; Provisional; Region: PRK06172 1093787010437 classical (c) SDRs; Region: SDR_c; cd05233 1093787010438 NAD(P) binding site [chemical binding]; other site 1093787010439 active site 1093787010440 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1093787010441 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1093787010442 NAD(P) binding site [chemical binding]; other site 1093787010443 substrate binding site [chemical binding]; other site 1093787010444 dimer interface [polypeptide binding]; other site 1093787010445 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1093787010446 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1093787010447 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1093787010448 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1093787010449 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787010450 dimerization interface [polypeptide binding]; other site 1093787010451 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1093787010452 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787010453 dimer interface [polypeptide binding]; other site 1093787010454 putative CheW interface [polypeptide binding]; other site 1093787010455 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1093787010456 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1093787010457 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1093787010458 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1093787010459 active site residue [active] 1093787010460 selenophosphate synthetase; Provisional; Region: PRK00943 1093787010461 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1093787010462 dimerization interface [polypeptide binding]; other site 1093787010463 putative ATP binding site [chemical binding]; other site 1093787010464 hypothetical protein; Provisional; Region: PRK10279 1093787010465 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1093787010466 active site 1093787010467 nucleophile elbow; other site 1093787010468 glutaminase; Provisional; Region: PRK00971 1093787010469 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1093787010470 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1093787010471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787010472 active site 1093787010473 phosphorylation site [posttranslational modification] 1093787010474 intermolecular recognition site; other site 1093787010475 dimerization interface [polypeptide binding]; other site 1093787010476 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787010477 DNA binding site [nucleotide binding] 1093787010478 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1093787010479 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1093787010480 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1093787010481 Ligand Binding Site [chemical binding]; other site 1093787010482 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1093787010483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787010484 dimer interface [polypeptide binding]; other site 1093787010485 phosphorylation site [posttranslational modification] 1093787010486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787010487 ATP binding site [chemical binding]; other site 1093787010488 Mg2+ binding site [ion binding]; other site 1093787010489 G-X-G motif; other site 1093787010490 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1093787010491 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1093787010492 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1093787010493 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1093787010494 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1093787010495 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1093787010496 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787010497 active site 1093787010498 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1093787010499 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1093787010500 Bacterial transcriptional regulator; Region: IclR; pfam01614 1093787010501 enoyl-CoA hydratase; Provisional; Region: PRK08138 1093787010502 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1093787010503 substrate binding site [chemical binding]; other site 1093787010504 oxyanion hole (OAH) forming residues; other site 1093787010505 trimer interface [polypeptide binding]; other site 1093787010506 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 1093787010507 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1093787010508 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1093787010509 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1093787010510 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1093787010511 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787010512 DNA-binding site [nucleotide binding]; DNA binding site 1093787010513 FCD domain; Region: FCD; pfam07729 1093787010514 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1093787010515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787010516 putative substrate translocation pore; other site 1093787010517 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1093787010518 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1093787010519 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1093787010520 C-terminal domain interface [polypeptide binding]; other site 1093787010521 GSH binding site (G-site) [chemical binding]; other site 1093787010522 dimer interface [polypeptide binding]; other site 1093787010523 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1093787010524 N-terminal domain interface [polypeptide binding]; other site 1093787010525 dimer interface [polypeptide binding]; other site 1093787010526 substrate binding pocket (H-site) [chemical binding]; other site 1093787010527 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1093787010528 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1093787010529 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1093787010530 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1093787010531 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1093787010532 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787010533 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787010534 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1093787010535 CoenzymeA binding site [chemical binding]; other site 1093787010536 subunit interaction site [polypeptide binding]; other site 1093787010537 PHB binding site; other site 1093787010538 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1093787010539 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 1093787010540 acyl-activating enzyme (AAE) consensus motif; other site 1093787010541 putative AMP binding site [chemical binding]; other site 1093787010542 putative active site [active] 1093787010543 putative CoA binding site [chemical binding]; other site 1093787010544 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1093787010545 catalytic core [active] 1093787010546 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 1093787010547 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1093787010548 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1093787010549 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1093787010550 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1093787010551 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1093787010552 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG2984 1093787010553 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787010554 dimerization interface [polypeptide binding]; other site 1093787010555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787010556 dimer interface [polypeptide binding]; other site 1093787010557 phosphorylation site [posttranslational modification] 1093787010558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787010559 ATP binding site [chemical binding]; other site 1093787010560 Mg2+ binding site [ion binding]; other site 1093787010561 G-X-G motif; other site 1093787010562 Response regulator receiver domain; Region: Response_reg; pfam00072 1093787010563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787010564 active site 1093787010565 phosphorylation site [posttranslational modification] 1093787010566 intermolecular recognition site; other site 1093787010567 dimerization interface [polypeptide binding]; other site 1093787010568 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1093787010569 active site 1 [active] 1093787010570 dimer interface [polypeptide binding]; other site 1093787010571 active site 2 [active] 1093787010572 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1093787010573 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1093787010574 dimer interface [polypeptide binding]; other site 1093787010575 active site 1093787010576 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1093787010577 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787010578 dimerization interface [polypeptide binding]; other site 1093787010579 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1093787010580 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787010581 dimer interface [polypeptide binding]; other site 1093787010582 putative CheW interface [polypeptide binding]; other site 1093787010583 Predicted transcriptional regulators [Transcription]; Region: COG1733 1093787010584 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1093787010585 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 1093787010586 Amidohydrolase; Region: Amidohydro_2; pfam04909 1093787010587 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1093787010588 membrane-bound complex binding site; other site 1093787010589 hinge residues; other site 1093787010590 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1093787010591 MarR family; Region: MarR; pfam01047 1093787010592 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1093787010593 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1093787010594 catalytic loop [active] 1093787010595 iron binding site [ion binding]; other site 1093787010596 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1093787010597 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1093787010598 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1093787010599 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1093787010600 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1093787010601 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1093787010602 cytochrome c-550; Provisional; Region: psbV; cl17239 1093787010603 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1093787010604 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1093787010605 Cupin domain; Region: Cupin_2; cl17218 1093787010606 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1093787010607 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787010608 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787010609 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1093787010610 oligomerization interface [polypeptide binding]; other site 1093787010611 active site 1093787010612 metal binding site [ion binding]; metal-binding site 1093787010613 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1093787010614 heat shock protein 90; Provisional; Region: PRK05218 1093787010615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787010616 ATP binding site [chemical binding]; other site 1093787010617 Mg2+ binding site [ion binding]; other site 1093787010618 G-X-G motif; other site 1093787010619 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1093787010620 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1093787010621 CoenzymeA binding site [chemical binding]; other site 1093787010622 subunit interaction site [polypeptide binding]; other site 1093787010623 PHB binding site; other site 1093787010624 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1093787010625 CoenzymeA binding site [chemical binding]; other site 1093787010626 subunit interaction site [polypeptide binding]; other site 1093787010627 PHB binding site; other site 1093787010628 Predicted membrane protein [Function unknown]; Region: COG3821 1093787010629 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1093787010630 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1093787010631 CoA binding domain; Region: CoA_binding; pfam02629 1093787010632 CoA-ligase; Region: Ligase_CoA; pfam00549 1093787010633 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1093787010634 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1093787010635 CoA-ligase; Region: Ligase_CoA; pfam00549 1093787010636 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1093787010637 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1093787010638 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1093787010639 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1093787010640 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1093787010641 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1093787010642 E3 interaction surface; other site 1093787010643 lipoyl attachment site [posttranslational modification]; other site 1093787010644 e3 binding domain; Region: E3_binding; pfam02817 1093787010645 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1093787010646 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1093787010647 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1093787010648 TPP-binding site [chemical binding]; other site 1093787010649 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1093787010650 PYR/PP interface [polypeptide binding]; other site 1093787010651 dimer interface [polypeptide binding]; other site 1093787010652 TPP binding site [chemical binding]; other site 1093787010653 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1093787010654 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1093787010655 L-aspartate oxidase; Provisional; Region: PRK06175 1093787010656 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675 1093787010657 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1093787010658 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1093787010659 SdhC subunit interface [polypeptide binding]; other site 1093787010660 proximal heme binding site [chemical binding]; other site 1093787010661 cardiolipin binding site; other site 1093787010662 Iron-sulfur protein interface; other site 1093787010663 proximal quinone binding site [chemical binding]; other site 1093787010664 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1093787010665 Iron-sulfur protein interface; other site 1093787010666 proximal quinone binding site [chemical binding]; other site 1093787010667 SdhD (CybS) interface [polypeptide binding]; other site 1093787010668 proximal heme binding site [chemical binding]; other site 1093787010669 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1093787010670 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1093787010671 dimer interface [polypeptide binding]; other site 1093787010672 active site 1093787010673 citrylCoA binding site [chemical binding]; other site 1093787010674 NADH binding [chemical binding]; other site 1093787010675 cationic pore residues; other site 1093787010676 oxalacetate/citrate binding site [chemical binding]; other site 1093787010677 coenzyme A binding site [chemical binding]; other site 1093787010678 catalytic triad [active] 1093787010679 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 1093787010680 putative lipid binding site [chemical binding]; other site 1093787010681 Flagellin N-methylase; Region: FliB; pfam03692 1093787010682 Protein of unknown function, DUF486; Region: DUF486; pfam04342 1093787010683 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1093787010684 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1093787010685 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1093787010686 active site 1093787010687 catalytic site [active] 1093787010688 substrate binding site [chemical binding]; other site 1093787010689 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 1093787010690 potential frameshift: common BLAST hit: gi|218892471|ref|YP_002441338.1| putative periplasmic protein 1093787010691 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 1093787010692 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1093787010693 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1093787010694 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787010695 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1093787010696 dimerization interface [polypeptide binding]; other site 1093787010697 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1093787010698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787010699 putative substrate translocation pore; other site 1093787010700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787010701 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1093787010702 homotrimer interaction site [polypeptide binding]; other site 1093787010703 putative active site [active] 1093787010704 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1093787010705 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1093787010706 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1093787010707 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1093787010708 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1093787010709 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1093787010710 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1093787010711 CPxP motif; other site 1093787010712 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1093787010713 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1093787010714 aconitate hydratase; Validated; Region: PRK09277 1093787010715 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1093787010716 substrate binding site [chemical binding]; other site 1093787010717 ligand binding site [chemical binding]; other site 1093787010718 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1093787010719 substrate binding site [chemical binding]; other site 1093787010720 PAS domain; Region: PAS_9; pfam13426 1093787010721 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787010722 putative active site [active] 1093787010723 heme pocket [chemical binding]; other site 1093787010724 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1093787010725 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787010726 dimer interface [polypeptide binding]; other site 1093787010727 putative CheW interface [polypeptide binding]; other site 1093787010728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787010729 NAD(P) binding site [chemical binding]; other site 1093787010730 active site 1093787010731 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 1093787010732 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1093787010733 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1093787010734 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1093787010735 Low-spin heme binding site [chemical binding]; other site 1093787010736 Putative water exit pathway; other site 1093787010737 Binuclear center (active site) [active] 1093787010738 Putative proton exit pathway; other site 1093787010739 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1093787010740 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 1093787010741 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 1093787010742 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1093787010743 Cytochrome c; Region: Cytochrom_C; pfam00034 1093787010744 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1093787010745 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1093787010746 Putative water exit pathway; other site 1093787010747 Binuclear center (active site) [active] 1093787010748 Putative proton exit pathway; other site 1093787010749 Low-spin heme binding site [chemical binding]; other site 1093787010750 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1093787010751 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 1093787010752 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 1093787010753 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1093787010754 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1093787010755 Cytochrome c; Region: Cytochrom_C; cl11414 1093787010756 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1093787010757 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1093787010758 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1093787010759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 1093787010760 FixH; Region: FixH; pfam05751 1093787010761 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 1093787010762 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1093787010763 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1093787010764 metal-binding site [ion binding] 1093787010765 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1093787010766 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1093787010767 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 1093787010768 Uncharacterized conserved protein [Function unknown]; Region: COG2836 1093787010769 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1093787010770 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1093787010771 FeS/SAM binding site; other site 1093787010772 HemN C-terminal domain; Region: HemN_C; pfam06969 1093787010773 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1093787010774 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1093787010775 ligand binding site [chemical binding]; other site 1093787010776 flexible hinge region; other site 1093787010777 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1093787010778 putative switch regulator; other site 1093787010779 non-specific DNA interactions [nucleotide binding]; other site 1093787010780 DNA binding site [nucleotide binding] 1093787010781 sequence specific DNA binding site [nucleotide binding]; other site 1093787010782 putative cAMP binding site [chemical binding]; other site 1093787010783 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1093787010784 active site 1093787010785 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1093787010786 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1093787010787 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1093787010788 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1093787010789 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1093787010790 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787010791 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1093787010792 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1093787010793 short chain dehydrogenase; Provisional; Region: PRK06181 1093787010794 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787010795 NAD(P) binding site [chemical binding]; other site 1093787010796 active site 1093787010797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 1093787010798 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1093787010799 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787010800 active site 1093787010801 recombination protein RecR; Reviewed; Region: recR; PRK00076 1093787010802 RecR protein; Region: RecR; pfam02132 1093787010803 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1093787010804 putative active site [active] 1093787010805 putative metal-binding site [ion binding]; other site 1093787010806 tetramer interface [polypeptide binding]; other site 1093787010807 hypothetical protein; Validated; Region: PRK00153 1093787010808 potential frameshift: common BLAST hit: gi|218892512|ref|YP_002441379.1| DNA polymerase III subunits gamma and tau 1093787010809 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 1093787010810 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787010811 substrate binding pocket [chemical binding]; other site 1093787010812 membrane-bound complex binding site; other site 1093787010813 hinge residues; other site 1093787010814 Ligase N family; Region: LIGANc; smart00532 1093787010815 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1093787010816 nucleotide binding pocket [chemical binding]; other site 1093787010817 K-X-D-G motif; other site 1093787010818 catalytic site [active] 1093787010819 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1093787010820 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1093787010821 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1093787010822 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1093787010823 Dimer interface [polypeptide binding]; other site 1093787010824 BRCT sequence motif; other site 1093787010825 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 1093787010826 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1093787010827 FtsZ protein binding site [polypeptide binding]; other site 1093787010828 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1093787010829 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1093787010830 Walker A/P-loop; other site 1093787010831 ATP binding site [chemical binding]; other site 1093787010832 Q-loop/lid; other site 1093787010833 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1093787010834 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1093787010835 ABC transporter signature motif; other site 1093787010836 Walker B; other site 1093787010837 D-loop; other site 1093787010838 H-loop/switch region; other site 1093787010839 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1093787010840 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787010841 DNA-binding site [nucleotide binding]; DNA binding site 1093787010842 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1093787010843 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1093787010844 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1093787010845 Di-iron ligands [ion binding]; other site 1093787010846 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 1093787010847 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1093787010848 catalytic loop [active] 1093787010849 iron binding site [ion binding]; other site 1093787010850 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1093787010851 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1093787010852 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1093787010853 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1093787010854 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1093787010855 guanine deaminase; Provisional; Region: PRK09228 1093787010856 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1093787010857 active site 1093787010858 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1093787010859 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787010860 DNA-binding site [nucleotide binding]; DNA binding site 1093787010861 FCD domain; Region: FCD; pfam07729 1093787010862 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1093787010863 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1093787010864 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1093787010865 active site 1093787010866 homotetramer interface [polypeptide binding]; other site 1093787010867 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1093787010868 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1093787010869 active site 1093787010870 catalytic site [active] 1093787010871 tetramer interface [polypeptide binding]; other site 1093787010872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 1093787010873 Allantoicase [Nucleotide transport and metabolism]; Region: Alc; COG4266 1093787010874 Allantoicase repeat; Region: Allantoicase; pfam03561 1093787010875 Allantoicase repeat; Region: Allantoicase; pfam03561 1093787010876 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1093787010877 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1093787010878 Predicted membrane protein [Function unknown]; Region: COG3748 1093787010879 Protein of unknown function (DUF989); Region: DUF989; pfam06181 1093787010880 Cytochrome c; Region: Cytochrom_C; pfam00034 1093787010881 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1093787010882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 1093787010883 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1093787010884 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1093787010885 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1093787010886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 1093787010887 PGAP1-like protein; Region: PGAP1; pfam07819 1093787010888 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cl00532 1093787010889 PAAR motif; Region: PAAR_motif; pfam05488 1093787010890 xanthine permease; Region: pbuX; TIGR03173 1093787010891 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 1093787010892 active site 1093787010893 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 1093787010894 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1093787010895 FeS/SAM binding site; other site 1093787010896 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1093787010897 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1093787010898 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787010899 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1093787010900 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 1093787010901 glyoxylate carboligase; Provisional; Region: PRK11269 1093787010902 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1093787010903 PYR/PP interface [polypeptide binding]; other site 1093787010904 dimer interface [polypeptide binding]; other site 1093787010905 TPP binding site [chemical binding]; other site 1093787010906 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1093787010907 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1093787010908 TPP-binding site [chemical binding]; other site 1093787010909 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1093787010910 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1093787010911 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1093787010912 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1093787010913 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1093787010914 MOFRL family; Region: MOFRL; pfam05161 1093787010915 pyruvate kinase; Provisional; Region: PRK06247 1093787010916 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1093787010917 domain interfaces; other site 1093787010918 active site 1093787010919 Urea transporter; Region: UT; cl01829 1093787010920 Ion transport protein; Region: Ion_trans; pfam00520 1093787010921 Ion channel; Region: Ion_trans_2; pfam07885 1093787010922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 1093787010923 conserved hypothetical protein; Region: TIGR02231 1093787010924 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 1093787010925 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1093787010926 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1093787010927 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1093787010928 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1093787010929 Domain of unknown function (DUF1937); Region: DUF1937; pfam09152 1093787010930 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 1093787010931 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1093787010932 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1093787010933 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1093787010934 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1093787010935 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1093787010936 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1093787010937 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1093787010938 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1093787010939 Proteobacterial glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK_like_proteobact; cd07794 1093787010940 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1093787010941 N- and C-terminal domain interface [polypeptide binding]; other site 1093787010942 active site 1093787010943 MgATP binding site [chemical binding]; other site 1093787010944 catalytic site [active] 1093787010945 metal binding site [ion binding]; metal-binding site 1093787010946 putative homotetramer interface [polypeptide binding]; other site 1093787010947 putative homodimer interface [polypeptide binding]; other site 1093787010948 putative glycerol binding site [chemical binding]; other site 1093787010949 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 1093787010950 homodimer interface [polypeptide binding]; other site 1093787010951 homotetramer interface [polypeptide binding]; other site 1093787010952 active site pocket [active] 1093787010953 cleavage site 1093787010954 Amino acid permease; Region: AA_permease_2; pfam13520 1093787010955 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1093787010956 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787010957 DNA binding residues [nucleotide binding] 1093787010958 dimerization interface [polypeptide binding]; other site 1093787010959 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1093787010960 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1093787010961 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 1093787010962 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1093787010963 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1093787010964 catalytic residues [active] 1093787010965 central insert; other site 1093787010966 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1093787010967 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 1093787010968 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1093787010969 heme exporter protein CcmC; Region: ccmC; TIGR01191 1093787010970 heme exporter protein CcmB; Region: ccmB; TIGR01190 1093787010971 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1093787010972 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 1093787010973 Walker A/P-loop; other site 1093787010974 ATP binding site [chemical binding]; other site 1093787010975 Q-loop/lid; other site 1093787010976 ABC transporter signature motif; other site 1093787010977 Walker B; other site 1093787010978 D-loop; other site 1093787010979 H-loop/switch region; other site 1093787010980 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1093787010981 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1093787010982 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1093787010983 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1093787010984 short chain dehydrogenase; Provisional; Region: PRK12937 1093787010985 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1093787010986 NADP binding site [chemical binding]; other site 1093787010987 homodimer interface [polypeptide binding]; other site 1093787010988 active site 1093787010989 substrate binding site [chemical binding]; other site 1093787010990 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1093787010991 Predicted transcriptional regulator [Transcription]; Region: COG2378 1093787010992 HTH domain; Region: HTH_11; pfam08279 1093787010993 WYL domain; Region: WYL; pfam13280 1093787010994 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1093787010995 C-terminal domain interface [polypeptide binding]; other site 1093787010996 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1093787010997 GSH binding site (G-site) [chemical binding]; other site 1093787010998 dimer interface [polypeptide binding]; other site 1093787010999 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1093787011000 N-terminal domain interface [polypeptide binding]; other site 1093787011001 dimer interface [polypeptide binding]; other site 1093787011002 substrate binding pocket (H-site) [chemical binding]; other site 1093787011003 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 1093787011004 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1093787011005 putative CheA interaction surface; other site 1093787011006 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1093787011007 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1093787011008 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1093787011009 P-loop; other site 1093787011010 Magnesium ion binding site [ion binding]; other site 1093787011011 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1093787011012 Magnesium ion binding site [ion binding]; other site 1093787011013 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1093787011014 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1093787011015 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1093787011016 ligand binding site [chemical binding]; other site 1093787011017 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1093787011018 flagellar motor protein; Reviewed; Region: motC; PRK09109 1093787011019 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1093787011020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787011021 active site 1093787011022 phosphorylation site [posttranslational modification] 1093787011023 intermolecular recognition site; other site 1093787011024 dimerization interface [polypeptide binding]; other site 1093787011025 CheB methylesterase; Region: CheB_methylest; pfam01339 1093787011026 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1093787011027 putative binding surface; other site 1093787011028 active site 1093787011029 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1093787011030 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1093787011031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787011032 ATP binding site [chemical binding]; other site 1093787011033 Mg2+ binding site [ion binding]; other site 1093787011034 G-X-G motif; other site 1093787011035 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1093787011036 Chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheZ; COG3143 1093787011037 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1093787011038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787011039 active site 1093787011040 phosphorylation site [posttranslational modification] 1093787011041 intermolecular recognition site; other site 1093787011042 dimerization interface [polypeptide binding]; other site 1093787011043 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1093787011044 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1093787011045 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1093787011046 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1093787011047 DNA binding residues [nucleotide binding] 1093787011048 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1093787011049 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1093787011050 P-loop; other site 1093787011051 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1093787011052 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1093787011053 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1093787011054 FHIPEP family; Region: FHIPEP; pfam00771 1093787011055 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1093787011056 Repair protein; Region: Repair_PSII; pfam04536 1093787011057 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1093787011058 Repair protein; Region: Repair_PSII; pfam04536 1093787011059 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1093787011060 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1093787011061 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1093787011062 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1093787011063 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1093787011064 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 1093787011065 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1093787011066 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1093787011067 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1093787011068 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1093787011069 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696 1093787011070 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1093787011071 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1093787011072 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1093787011073 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 1093787011074 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1093787011075 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1093787011076 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787011077 dimer interface [polypeptide binding]; other site 1093787011078 phosphorylation site [posttranslational modification] 1093787011079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787011080 ATP binding site [chemical binding]; other site 1093787011081 Mg2+ binding site [ion binding]; other site 1093787011082 G-X-G motif; other site 1093787011083 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1093787011084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787011085 active site 1093787011086 phosphorylation site [posttranslational modification] 1093787011087 intermolecular recognition site; other site 1093787011088 dimerization interface [polypeptide binding]; other site 1093787011089 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787011090 DNA binding site [nucleotide binding] 1093787011091 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1093787011092 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1093787011093 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787011094 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787011095 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 1093787011096 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787011097 metal binding site [ion binding]; metal-binding site 1093787011098 active site 1093787011099 I-site; other site 1093787011100 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1093787011101 N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916 1093787011102 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1093787011103 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1093787011104 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1093787011105 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787011106 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787011107 Walker A/P-loop; other site 1093787011108 Walker A/P-loop; other site 1093787011109 ATP binding site [chemical binding]; other site 1093787011110 ATP binding site [chemical binding]; other site 1093787011111 Q-loop/lid; other site 1093787011112 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787011113 Q-loop/lid; other site 1093787011114 ABC transporter signature motif; other site 1093787011115 ABC transporter signature motif; other site 1093787011116 Walker B; other site 1093787011117 Walker B; other site 1093787011118 D-loop; other site 1093787011119 H-loop/switch region; other site 1093787011120 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1093787011121 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1093787011122 PAS domain; Region: PAS_9; pfam13426 1093787011123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787011124 putative active site [active] 1093787011125 heme pocket [chemical binding]; other site 1093787011126 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787011127 PAS domain; Region: PAS_9; pfam13426 1093787011128 putative active site [active] 1093787011129 heme pocket [chemical binding]; other site 1093787011130 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1093787011131 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787011132 dimer interface [polypeptide binding]; other site 1093787011133 putative CheW interface [polypeptide binding]; other site 1093787011134 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787011135 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787011136 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1093787011137 dimerization interface [polypeptide binding]; other site 1093787011138 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1093787011139 agmatinase; Region: agmatinase; TIGR01230 1093787011140 oligomer interface [polypeptide binding]; other site 1093787011141 putative active site [active] 1093787011142 Mn binding site [ion binding]; other site 1093787011143 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1093787011144 SnoaL-like domain; Region: SnoaL_3; pfam13474 1093787011145 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1093787011146 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1093787011147 Na binding site [ion binding]; other site 1093787011148 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 1093787011149 Na binding site [ion binding]; other site 1093787011150 hypothetical protein; Provisional; Region: PRK07524 1093787011151 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1093787011152 PYR/PP interface [polypeptide binding]; other site 1093787011153 dimer interface [polypeptide binding]; other site 1093787011154 TPP binding site [chemical binding]; other site 1093787011155 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1093787011156 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1093787011157 TPP-binding site [chemical binding]; other site 1093787011158 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1093787011159 FAD binding domain; Region: FAD_binding_4; pfam01565 1093787011160 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1093787011161 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787011162 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787011163 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1093787011164 putative dimerization interface [polypeptide binding]; other site 1093787011165 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1093787011166 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1093787011167 EamA-like transporter family; Region: EamA; pfam00892 1093787011168 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1093787011169 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1093787011170 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1093787011171 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1093787011172 active site 1093787011173 Zn binding site [ion binding]; other site 1093787011174 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 1093787011175 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 1093787011176 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1093787011177 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 1093787011178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787011179 S-adenosylmethionine binding site [chemical binding]; other site 1093787011180 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1093787011181 active site 1093787011182 NTP binding site [chemical binding]; other site 1093787011183 metal binding triad [ion binding]; metal-binding site 1093787011184 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1093787011185 Family description; Region: UvrD_C_2; pfam13538 1093787011186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787011187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787011188 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1093787011189 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1093787011190 Predicted ester cyclase [General function prediction only]; Region: COG5485 1093787011191 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1093787011192 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1093787011193 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1093787011194 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1093787011195 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1093787011196 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1093787011197 carboxyltransferase (CT) interaction site; other site 1093787011198 biotinylation site [posttranslational modification]; other site 1093787011199 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1093787011200 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1093787011201 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787011202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787011203 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1093787011204 substrate binding pocket [chemical binding]; other site 1093787011205 dimerization interface [polypeptide binding]; other site 1093787011206 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1093787011207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787011208 active site 1093787011209 phosphorylation site [posttranslational modification] 1093787011210 intermolecular recognition site; other site 1093787011211 dimerization interface [polypeptide binding]; other site 1093787011212 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787011213 DNA binding residues [nucleotide binding] 1093787011214 dimerization interface [polypeptide binding]; other site 1093787011215 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1093787011216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787011217 dimer interface [polypeptide binding]; other site 1093787011218 phosphorylation site [posttranslational modification] 1093787011219 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1093787011220 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787011221 ATP binding site [chemical binding]; other site 1093787011222 Mg2+ binding site [ion binding]; other site 1093787011223 G-X-G motif; other site 1093787011224 Response regulator receiver domain; Region: Response_reg; pfam00072 1093787011225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787011226 active site 1093787011227 phosphorylation site [posttranslational modification] 1093787011228 intermolecular recognition site; other site 1093787011229 dimerization interface [polypeptide binding]; other site 1093787011230 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1093787011231 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787011232 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787011233 active site 1093787011234 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1093787011235 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1093787011236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787011237 Coenzyme A binding pocket [chemical binding]; other site 1093787011238 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1093787011239 Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; pfam06315 1093787011240 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 1093787011241 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1093787011242 ligand binding site [chemical binding]; other site 1093787011243 NAD binding site [chemical binding]; other site 1093787011244 catalytic site [active] 1093787011245 homodimer interface [polypeptide binding]; other site 1093787011246 Predicted transcriptional regulators [Transcription]; Region: COG1733 1093787011247 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1093787011248 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 1093787011249 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1093787011250 dimer interface [polypeptide binding]; other site 1093787011251 active site 1093787011252 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1093787011253 Secretin and TonB N terminus short domain; Region: STN; smart00965 1093787011254 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1093787011255 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787011256 N-terminal plug; other site 1093787011257 ligand-binding site [chemical binding]; other site 1093787011258 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1093787011259 FecR protein; Region: FecR; pfam04773 1093787011260 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1093787011261 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1093787011262 DNA binding residues [nucleotide binding] 1093787011263 multidrug efflux protein; Reviewed; Region: PRK01766 1093787011264 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1093787011265 cation binding site [ion binding]; other site 1093787011266 threonine and homoserine efflux system; Provisional; Region: PRK10532 1093787011267 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1093787011268 non-specific DNA binding site [nucleotide binding]; other site 1093787011269 salt bridge; other site 1093787011270 sequence-specific DNA binding site [nucleotide binding]; other site 1093787011271 Cupin domain; Region: Cupin_2; pfam07883 1093787011272 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1093787011273 dimer interface [polypeptide binding]; other site 1093787011274 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1093787011275 putative deacylase active site [active] 1093787011276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1093787011277 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1093787011278 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1093787011279 dimer interface [polypeptide binding]; other site 1093787011280 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1093787011281 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1093787011282 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1093787011283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312 1093787011284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1093787011285 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1093787011286 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787011287 DNA binding residues [nucleotide binding] 1093787011288 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1093787011289 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1093787011290 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1093787011291 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 1093787011292 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 1093787011293 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1093787011294 short chain dehydrogenase; Provisional; Region: PRK06523 1093787011295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787011296 NAD(P) binding site [chemical binding]; other site 1093787011297 active site 1093787011298 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1093787011299 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787011300 substrate binding pocket [chemical binding]; other site 1093787011301 membrane-bound complex binding site; other site 1093787011302 hinge residues; other site 1093787011303 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1093787011304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787011305 dimer interface [polypeptide binding]; other site 1093787011306 conserved gate region; other site 1093787011307 putative PBP binding loops; other site 1093787011308 ABC-ATPase subunit interface; other site 1093787011309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787011310 dimer interface [polypeptide binding]; other site 1093787011311 conserved gate region; other site 1093787011312 putative PBP binding loops; other site 1093787011313 ABC-ATPase subunit interface; other site 1093787011314 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1093787011315 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1093787011316 Walker A/P-loop; other site 1093787011317 ATP binding site [chemical binding]; other site 1093787011318 Q-loop/lid; other site 1093787011319 ABC transporter signature motif; other site 1093787011320 Walker B; other site 1093787011321 D-loop; other site 1093787011322 H-loop/switch region; other site 1093787011323 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1093787011324 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1093787011325 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 1093787011326 homodimer interface [polypeptide binding]; other site 1093787011327 active site 1093787011328 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1093787011329 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787011330 dimer interface [polypeptide binding]; other site 1093787011331 phosphorylation site [posttranslational modification] 1093787011332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787011333 ATP binding site [chemical binding]; other site 1093787011334 Mg2+ binding site [ion binding]; other site 1093787011335 G-X-G motif; other site 1093787011336 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1093787011337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787011338 active site 1093787011339 phosphorylation site [posttranslational modification] 1093787011340 intermolecular recognition site; other site 1093787011341 dimerization interface [polypeptide binding]; other site 1093787011342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787011343 Walker A motif; other site 1093787011344 ATP binding site [chemical binding]; other site 1093787011345 Walker B motif; other site 1093787011346 arginine finger; other site 1093787011347 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1093787011348 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1093787011349 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1093787011350 FMN binding site [chemical binding]; other site 1093787011351 active site 1093787011352 substrate binding site [chemical binding]; other site 1093787011353 catalytic residue [active] 1093787011354 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1093787011355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787011356 S-adenosylmethionine binding site [chemical binding]; other site 1093787011357 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1093787011358 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1093787011359 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1093787011360 Transporter associated domain; Region: CorC_HlyC; smart01091 1093787011361 short chain dehydrogenase; Provisional; Region: PRK09291 1093787011362 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1093787011363 NADP binding site [chemical binding]; other site 1093787011364 active site 1093787011365 steroid binding site; other site 1093787011366 Domain of unknown function (DUF336); Region: DUF336; cl01249 1093787011367 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787011368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787011369 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1093787011370 putative effector binding pocket; other site 1093787011371 putative dimerization interface [polypeptide binding]; other site 1093787011372 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1093787011373 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1093787011374 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1093787011375 active site 1093787011376 substrate binding site [chemical binding]; other site 1093787011377 Mg2+ binding site [ion binding]; other site 1093787011378 threonine dehydratase; Reviewed; Region: PRK09224 1093787011379 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1093787011380 tetramer interface [polypeptide binding]; other site 1093787011381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787011382 catalytic residue [active] 1093787011383 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1093787011384 putative Ile/Val binding site [chemical binding]; other site 1093787011385 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1093787011386 putative Ile/Val binding site [chemical binding]; other site 1093787011387 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1093787011388 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1093787011389 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1093787011390 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787011391 N-terminal plug; other site 1093787011392 ligand-binding site [chemical binding]; other site 1093787011393 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1093787011394 UbiA prenyltransferase family; Region: UbiA; pfam01040 1093787011395 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 1093787011396 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1093787011397 Subunit I/III interface [polypeptide binding]; other site 1093787011398 Subunit III/IV interface [polypeptide binding]; other site 1093787011399 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1093787011400 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1093787011401 D-pathway; other site 1093787011402 Putative ubiquinol binding site [chemical binding]; other site 1093787011403 Low-spin heme (heme b) binding site [chemical binding]; other site 1093787011404 Putative water exit pathway; other site 1093787011405 Binuclear center (heme o3/CuB) [ion binding]; other site 1093787011406 K-pathway; other site 1093787011407 Putative proton exit pathway; other site 1093787011408 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 1093787011409 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1093787011410 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1093787011411 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1093787011412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787011413 putative substrate translocation pore; other site 1093787011414 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787011415 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787011416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1093787011417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787011418 putative substrate translocation pore; other site 1093787011419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787011420 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787011421 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787011422 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1093787011423 putative effector binding pocket; other site 1093787011424 dimerization interface [polypeptide binding]; other site 1093787011425 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1093787011426 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1093787011427 motif II; other site 1093787011428 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 1093787011429 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1093787011430 catalytic residue [active] 1093787011431 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787011432 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1093787011433 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1093787011434 dimerization interface [polypeptide binding]; other site 1093787011435 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 1093787011436 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1093787011437 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1093787011438 putative active site [active] 1093787011439 putative dimer interface [polypeptide binding]; other site 1093787011440 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1093787011441 nucleotide binding site/active site [active] 1093787011442 HIT family signature motif; other site 1093787011443 catalytic residue [active] 1093787011444 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1093787011445 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1093787011446 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1093787011447 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1093787011448 Catalytic site [active] 1093787011449 Secretin and TonB N terminus short domain; Region: STN; smart00965 1093787011450 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1093787011451 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787011452 N-terminal plug; other site 1093787011453 ligand-binding site [chemical binding]; other site 1093787011454 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1093787011455 FecR protein; Region: FecR; pfam04773 1093787011456 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1093787011457 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1093787011458 hypothetical protein; Provisional; Region: PRK05170 1093787011459 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1093787011460 putative metal binding site [ion binding]; other site 1093787011461 putative homodimer interface [polypeptide binding]; other site 1093787011462 putative homotetramer interface [polypeptide binding]; other site 1093787011463 putative homodimer-homodimer interface [polypeptide binding]; other site 1093787011464 putative allosteric switch controlling residues; other site 1093787011465 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1093787011466 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1093787011467 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1093787011468 NAD binding site [chemical binding]; other site 1093787011469 ligand binding site [chemical binding]; other site 1093787011470 catalytic site [active] 1093787011471 YcgL domain; Region: YcgL; pfam05166 1093787011472 ribonuclease D; Region: rnd; TIGR01388 1093787011473 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1093787011474 catalytic site [active] 1093787011475 putative active site [active] 1093787011476 putative substrate binding site [chemical binding]; other site 1093787011477 HRDC domain; Region: HRDC; pfam00570 1093787011478 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1093787011479 Strictosidine synthase; Region: Str_synth; pfam03088 1093787011480 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1093787011481 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1093787011482 active site residue [active] 1093787011483 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1093787011484 active site residue [active] 1093787011485 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1093787011486 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787011487 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787011488 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 1093787011489 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1093787011490 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1093787011491 catalytic residues [active] 1093787011492 dimer interface [polypeptide binding]; other site 1093787011493 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1093787011494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787011495 MarR family; Region: MarR_2; pfam12802 1093787011496 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1093787011497 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1093787011498 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787011499 active site 1093787011500 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1093787011501 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787011502 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787011503 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1093787011504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787011505 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1093787011506 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1093787011507 catalytic core [active] 1093787011508 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1093787011509 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1093787011510 putative dimer interface [polypeptide binding]; other site 1093787011511 active site pocket [active] 1093787011512 putative cataytic base [active] 1093787011513 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1093787011514 homotrimer interface [polypeptide binding]; other site 1093787011515 Walker A motif; other site 1093787011516 GTP binding site [chemical binding]; other site 1093787011517 Walker B motif; other site 1093787011518 cobyric acid synthase; Provisional; Region: PRK00784 1093787011519 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1093787011520 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1093787011521 catalytic triad [active] 1093787011522 threonine-phosphate decarboxylase; Reviewed; Region: PRK05664 1093787011523 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1093787011524 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1093787011525 catalytic residue [active] 1093787011526 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1093787011527 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1093787011528 FMN binding site [chemical binding]; other site 1093787011529 dimer interface [polypeptide binding]; other site 1093787011530 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1093787011531 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 1093787011532 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1093787011533 catalytic triad [active] 1093787011534 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 1093787011535 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1093787011536 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1093787011537 homodimer interface [polypeptide binding]; other site 1093787011538 Walker A motif; other site 1093787011539 ATP binding site [chemical binding]; other site 1093787011540 hydroxycobalamin binding site [chemical binding]; other site 1093787011541 Walker B motif; other site 1093787011542 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 1093787011543 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787011544 N-terminal plug; other site 1093787011545 ligand-binding site [chemical binding]; other site 1093787011546 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1093787011547 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1093787011548 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1093787011549 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787011550 DNA-binding site [nucleotide binding]; DNA binding site 1093787011551 FCD domain; Region: FCD; pfam07729 1093787011552 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 1093787011553 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1093787011554 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1093787011555 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1093787011556 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1093787011557 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1093787011558 EamA-like transporter family; Region: EamA; pfam00892 1093787011559 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787011560 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787011561 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787011562 Helix-turn-helix domain; Region: HTH_31; pfam13560 1093787011563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787011564 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1093787011565 putative substrate translocation pore; other site 1093787011566 PAS fold; Region: PAS_4; pfam08448 1093787011567 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787011568 putative active site [active] 1093787011569 heme pocket [chemical binding]; other site 1093787011570 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787011571 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787011572 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787011573 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1093787011574 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787011575 substrate binding pocket [chemical binding]; other site 1093787011576 membrane-bound complex binding site; other site 1093787011577 hinge residues; other site 1093787011578 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 1093787011579 substrate binding site [chemical binding]; other site 1093787011580 Protein of unknown function (DUF521); Region: DUF521; pfam04412 1093787011581 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 1093787011582 substrate binding site [chemical binding]; other site 1093787011583 ligand binding site [chemical binding]; other site 1093787011584 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1093787011585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787011586 dimer interface [polypeptide binding]; other site 1093787011587 conserved gate region; other site 1093787011588 putative PBP binding loops; other site 1093787011589 ABC-ATPase subunit interface; other site 1093787011590 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1093787011591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787011592 dimer interface [polypeptide binding]; other site 1093787011593 conserved gate region; other site 1093787011594 putative PBP binding loops; other site 1093787011595 ABC-ATPase subunit interface; other site 1093787011596 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1093787011597 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1093787011598 Walker A/P-loop; other site 1093787011599 ATP binding site [chemical binding]; other site 1093787011600 Q-loop/lid; other site 1093787011601 ABC transporter signature motif; other site 1093787011602 Walker B; other site 1093787011603 D-loop; other site 1093787011604 H-loop/switch region; other site 1093787011605 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 1093787011606 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1093787011607 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1093787011608 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1093787011609 inhibitor site; inhibition site 1093787011610 active site 1093787011611 dimer interface [polypeptide binding]; other site 1093787011612 catalytic residue [active] 1093787011613 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1093787011614 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1093787011615 dimer interface [polypeptide binding]; other site 1093787011616 NADP binding site [chemical binding]; other site 1093787011617 catalytic residues [active] 1093787011618 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1093787011619 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1093787011620 HAMP domain; Region: HAMP; pfam00672 1093787011621 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1093787011622 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787011623 dimer interface [polypeptide binding]; other site 1093787011624 putative CheW interface [polypeptide binding]; other site 1093787011625 Protease inhibitor Inh; Region: Inh; pfam02974 1093787011626 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1093787011627 active site 1093787011628 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1093787011629 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1093787011630 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1093787011631 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787011632 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787011633 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 1093787011634 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1093787011635 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787011636 Walker A/P-loop; other site 1093787011637 ATP binding site [chemical binding]; other site 1093787011638 Q-loop/lid; other site 1093787011639 ABC transporter signature motif; other site 1093787011640 Walker B; other site 1093787011641 D-loop; other site 1093787011642 H-loop/switch region; other site 1093787011643 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1093787011644 GAF domain; Region: GAF; pfam01590 1093787011645 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787011646 PAS domain; Region: PAS_9; pfam13426 1093787011647 putative active site [active] 1093787011648 heme pocket [chemical binding]; other site 1093787011649 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1093787011650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787011651 dimer interface [polypeptide binding]; other site 1093787011652 phosphorylation site [posttranslational modification] 1093787011653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787011654 ATP binding site [chemical binding]; other site 1093787011655 Mg2+ binding site [ion binding]; other site 1093787011656 G-X-G motif; other site 1093787011657 Response regulator receiver domain; Region: Response_reg; pfam00072 1093787011658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787011659 active site 1093787011660 phosphorylation site [posttranslational modification] 1093787011661 intermolecular recognition site; other site 1093787011662 dimerization interface [polypeptide binding]; other site 1093787011663 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1093787011664 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1093787011665 active site 1093787011666 catalytic residues [active] 1093787011667 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1093787011668 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1093787011669 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787011670 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1093787011671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787011672 putative substrate translocation pore; other site 1093787011673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787011674 Cupin domain; Region: Cupin_2; pfam07883 1093787011675 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787011676 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787011677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787011678 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1093787011679 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1093787011680 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1093787011681 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787011682 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787011683 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1093787011684 Phosphotransferase enzyme family; Region: APH; pfam01636 1093787011685 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787011686 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787011687 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1093787011688 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1093787011689 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1093787011690 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1093787011691 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787011692 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787011693 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 1093787011694 putative substrate binding pocket [chemical binding]; other site 1093787011695 putative dimerization interface [polypeptide binding]; other site 1093787011696 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1093787011697 MltA specific insert domain; Region: MltA; pfam03562 1093787011698 3D domain; Region: 3D; pfam06725 1093787011699 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1093787011700 acyl-activating enzyme (AAE) consensus motif; other site 1093787011701 AMP binding site [chemical binding]; other site 1093787011702 active site 1093787011703 CoA binding site [chemical binding]; other site 1093787011704 Thioesterase domain; Region: Thioesterase; pfam00975 1093787011705 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1093787011706 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1093787011707 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1093787011708 active site 1093787011709 catalytic residues [active] 1093787011710 metal binding site [ion binding]; metal-binding site 1093787011711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787011712 S-adenosylmethionine binding site [chemical binding]; other site 1093787011713 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1093787011714 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1093787011715 acyl-activating enzyme (AAE) consensus motif; other site 1093787011716 AMP binding site [chemical binding]; other site 1093787011717 active site 1093787011718 CoA binding site [chemical binding]; other site 1093787011719 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1093787011720 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1093787011721 active site 1093787011722 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1093787011723 Ligand Binding Site [chemical binding]; other site 1093787011724 Molecular Tunnel; other site 1093787011725 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 1093787011726 substrate binding pocket [chemical binding]; other site 1093787011727 active site 1093787011728 iron coordination sites [ion binding]; other site 1093787011729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787011730 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1093787011731 putative substrate translocation pore; other site 1093787011732 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1093787011733 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1093787011734 Pirin-related protein [General function prediction only]; Region: COG1741 1093787011735 Pirin; Region: Pirin; pfam02678 1093787011736 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1093787011737 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1093787011738 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1093787011739 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1093787011740 active site residue [active] 1093787011741 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1093787011742 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1093787011743 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1093787011744 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1093787011745 TrkA-N domain; Region: TrkA_N; pfam02254 1093787011746 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 1093787011747 putative hydrophobic ligand binding site [chemical binding]; other site 1093787011748 Pirin-related protein [General function prediction only]; Region: COG1741 1093787011749 Pirin; Region: Pirin; pfam02678 1093787011750 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1093787011751 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1093787011752 Predicted flavoprotein [General function prediction only]; Region: COG0431 1093787011753 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1093787011754 Isochorismatase family; Region: Isochorismatase; pfam00857 1093787011755 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1093787011756 catalytic triad [active] 1093787011757 dimer interface [polypeptide binding]; other site 1093787011758 conserved cis-peptide bond; other site 1093787011759 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787011760 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787011761 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1093787011762 putative effector binding pocket; other site 1093787011763 dimerization interface [polypeptide binding]; other site 1093787011764 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1093787011765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787011766 S-adenosylmethionine binding site [chemical binding]; other site 1093787011767 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1093787011768 NlpC/P60 family; Region: NLPC_P60; pfam00877 1093787011769 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1093787011770 NlpC/P60 family; Region: NLPC_P60; pfam00877 1093787011771 NAD-dependent deacetylase; Provisional; Region: PRK00481 1093787011772 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1093787011773 NAD+ binding site [chemical binding]; other site 1093787011774 substrate binding site [chemical binding]; other site 1093787011775 Zn binding site [ion binding]; other site 1093787011776 PAS fold; Region: PAS_4; pfam08448 1093787011777 photoactive yellow protein; Region: photo_yellow; TIGR02373 1093787011778 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1093787011779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787011780 Walker A motif; other site 1093787011781 ATP binding site [chemical binding]; other site 1093787011782 Walker B motif; other site 1093787011783 arginine finger; other site 1093787011784 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1093787011785 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1093787011786 Amidinotransferase; Region: Amidinotransf; cl12043 1093787011787 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1093787011788 3-methyladenine DNA glycosylase [DNA replication, recombination, and repair]; Region: Tag; COG2818 1093787011789 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1093787011790 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1093787011791 Ligand Binding Site [chemical binding]; other site 1093787011792 DNA-J related protein; Region: DNAJ_related; pfam12339 1093787011793 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 1093787011794 HSP70 interaction site [polypeptide binding]; other site 1093787011795 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1093787011796 hypothetical protein; Provisional; Region: PRK04860 1093787011797 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1093787011798 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1093787011799 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1093787011800 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1093787011801 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787011802 active site 1093787011803 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 1093787011804 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1093787011805 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1093787011806 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1093787011807 C-terminal domain interface [polypeptide binding]; other site 1093787011808 GSH binding site (G-site) [chemical binding]; other site 1093787011809 dimer interface [polypeptide binding]; other site 1093787011810 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 1093787011811 dimer interface [polypeptide binding]; other site 1093787011812 N-terminal domain interface [polypeptide binding]; other site 1093787011813 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1093787011814 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787011815 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1093787011816 dimerization interface [polypeptide binding]; other site 1093787011817 substrate binding pocket [chemical binding]; other site 1093787011818 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1093787011819 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1093787011820 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1093787011821 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787011822 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787011823 potential frameshift: common BLAST hit: gi|116049113|ref|YP_792085.1| putative sensor protein 1093787011824 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787011825 dimer interface [polypeptide binding]; other site 1093787011826 phosphorylation site [posttranslational modification] 1093787011827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787011828 ATP binding site [chemical binding]; other site 1093787011829 G-X-G motif; other site 1093787011830 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1093787011831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787011832 active site 1093787011833 phosphorylation site [posttranslational modification] 1093787011834 intermolecular recognition site; other site 1093787011835 dimerization interface [polypeptide binding]; other site 1093787011836 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787011837 DNA binding site [nucleotide binding] 1093787011838 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1093787011839 Periplasmic nitrate reductase system, NapE component [Energy production and conversion]; Region: NapE; COG4459 1093787011840 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1093787011841 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1093787011842 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1093787011843 Uncharacterized protein involved in formation of periplasmic nitrate reductase [Inorganic ion transport and metabolism]; Region: NapD; COG3062 1093787011844 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1093787011845 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1093787011846 [4Fe-4S] binding site [ion binding]; other site 1093787011847 molybdopterin cofactor binding site; other site 1093787011848 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1093787011849 molybdopterin cofactor binding site; other site 1093787011850 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 1093787011851 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 1093787011852 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 1093787011853 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1093787011854 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1093787011855 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1093787011856 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1093787011857 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1093787011858 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1093787011859 Lipoxygenase; Region: Lipoxygenase; pfam00305 1093787011860 Alginate lyase; Region: Alginate_lyase2; pfam08787 1093787011861 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1093787011862 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1093787011863 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1093787011864 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1093787011865 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1093787011866 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1093787011867 putative ATP binding site [chemical binding]; other site 1093787011868 putative substrate interface [chemical binding]; other site 1093787011869 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1093787011870 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1093787011871 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1093787011872 active site 1093787011873 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1093787011874 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1093787011875 metal binding site [ion binding]; metal-binding site 1093787011876 dimer interface [polypeptide binding]; other site 1093787011877 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1093787011878 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1093787011879 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1093787011880 DNA-binding site [nucleotide binding]; DNA binding site 1093787011881 RNA-binding motif; other site 1093787011882 sensor protein RstB; Provisional; Region: PRK10604 1093787011883 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787011884 dimerization interface [polypeptide binding]; other site 1093787011885 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787011886 dimer interface [polypeptide binding]; other site 1093787011887 phosphorylation site [posttranslational modification] 1093787011888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787011889 ATP binding site [chemical binding]; other site 1093787011890 Mg2+ binding site [ion binding]; other site 1093787011891 G-X-G motif; other site 1093787011892 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1093787011893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787011894 active site 1093787011895 phosphorylation site [posttranslational modification] 1093787011896 intermolecular recognition site; other site 1093787011897 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787011898 DNA binding site [nucleotide binding] 1093787011899 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 1093787011900 ATP cone domain; Region: ATP-cone; pfam03477 1093787011901 ATP cone domain; Region: ATP-cone; pfam03477 1093787011902 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1093787011903 active site 1093787011904 dimer interface [polypeptide binding]; other site 1093787011905 catalytic residues [active] 1093787011906 effector binding site; other site 1093787011907 R2 peptide binding site; other site 1093787011908 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1093787011909 dimer interface [polypeptide binding]; other site 1093787011910 putative radical transfer pathway; other site 1093787011911 diiron center [ion binding]; other site 1093787011912 tyrosyl radical; other site 1093787011913 HTH-like domain; Region: HTH_21; pfam13276 1093787011914 Integrase core domain; Region: rve; pfam00665 1093787011915 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1093787011916 Integrase core domain; Region: rve_3; pfam13683 1093787011917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1093787011918 Transposase; Region: HTH_Tnp_1; pfam01527 1093787011919 Prophage antirepressor [Transcription]; Region: COG3617 1093787011920 BRO family, N-terminal domain; Region: Bro-N; cl10591 1093787011921 Bacterial self-protective colicin-like immunity; Region: Colicin_immun; pfam09204 1093787011922 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 1093787011923 Uncharacterized protein conserved in bacteria (DUF2195); Region: DUF2195; cl02042 1093787011924 Exotoxin A binding; Region: Exotox-A_bind; pfam09101 1093787011925 Exotoxin A, targeting; Region: Exotox-A_target; pfam09102 1093787011926 Mono-ADP-ribosylating toxins catalyze the transfer of ADP_ribose from NAD+ to eukaryotic Elongation Factor 2, halting protein synthesis. A single molecule of delivered toxin is sufficient to kill a cell. These toxins share mono-ADP-ribosylating activity...; Region: Dipth_tox_like; cd01436 1093787011927 nad+ binding pocket [chemical binding]; other site 1093787011928 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 1093787011929 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1093787011930 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 1093787011931 putative active site [active] 1093787011932 metal binding site [ion binding]; metal-binding site 1093787011933 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787011934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787011935 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1093787011936 dimerization interface [polypeptide binding]; other site 1093787011937 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1093787011938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787011939 putative substrate translocation pore; other site 1093787011940 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1093787011941 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1093787011942 transcriptional regulator protein; Region: phnR; TIGR03337 1093787011943 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787011944 DNA-binding site [nucleotide binding]; DNA binding site 1093787011945 UTRA domain; Region: UTRA; pfam07702 1093787011946 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1093787011947 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1093787011948 putative trimer interface [polypeptide binding]; other site 1093787011949 putative CoA binding site [chemical binding]; other site 1093787011950 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787011951 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787011952 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1093787011953 dimerization interface [polypeptide binding]; other site 1093787011954 hypothetical protein; Provisional; Region: PRK11171 1093787011955 Cupin domain; Region: Cupin_2; pfam07883 1093787011956 Cupin domain; Region: Cupin_2; pfam07883 1093787011957 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1093787011958 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1093787011959 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787011960 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787011961 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1093787011962 dimerization interface [polypeptide binding]; other site 1093787011963 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1093787011964 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1093787011965 NAD(P) binding site [chemical binding]; other site 1093787011966 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 1093787011967 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1093787011968 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787011969 DNA binding residues [nucleotide binding] 1093787011970 dimerization interface [polypeptide binding]; other site 1093787011971 chaperone protein HchA; Provisional; Region: PRK04155 1093787011972 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1093787011973 conserved cys residue [active] 1093787011974 Protein of unknown function, DUF393; Region: DUF393; cl01136 1093787011975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787011976 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1093787011977 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 1093787011978 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 1093787011979 Ligand binding site; other site 1093787011980 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 1093787011981 dimer interface [polypeptide binding]; other site 1093787011982 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1093787011983 Mn binding site [ion binding]; other site 1093787011984 K binding site [ion binding]; other site 1093787011985 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787011986 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787011987 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1093787011988 putative effector binding pocket; other site 1093787011989 putative dimerization interface [polypeptide binding]; other site 1093787011990 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1093787011991 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1093787011992 active site 1093787011993 catalytic tetrad [active] 1093787011994 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 1093787011995 NAD-dependent deacetylase; Provisional; Region: PRK00481 1093787011996 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1093787011997 NAD+ binding site [chemical binding]; other site 1093787011998 substrate binding site [chemical binding]; other site 1093787011999 Zn binding site [ion binding]; other site 1093787012000 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1093787012001 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1093787012002 Zn2+ binding site [ion binding]; other site 1093787012003 Mg2+ binding site [ion binding]; other site 1093787012004 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1093787012005 Protein of unknown function (DUF2025); Region: DUF2025; pfam09634 1093787012006 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1093787012007 active site 1093787012008 catalytic residues [active] 1093787012009 metal binding site [ion binding]; metal-binding site 1093787012010 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1093787012011 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1093787012012 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787012013 dimerization interface [polypeptide binding]; other site 1093787012014 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787012015 metal binding site [ion binding]; metal-binding site 1093787012016 active site 1093787012017 I-site; other site 1093787012018 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1093787012019 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1093787012020 ligand binding site [chemical binding]; other site 1093787012021 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1093787012022 S1 domain; Region: S1_2; pfam13509 1093787012023 S1 domain; Region: S1_2; pfam13509 1093787012024 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1093787012025 Sulfatase; Region: Sulfatase; pfam00884 1093787012026 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1093787012027 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1093787012028 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 1093787012029 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1093787012030 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787012031 Walker A/P-loop; other site 1093787012032 ATP binding site [chemical binding]; other site 1093787012033 Q-loop/lid; other site 1093787012034 ABC transporter signature motif; other site 1093787012035 Walker B; other site 1093787012036 D-loop; other site 1093787012037 H-loop/switch region; other site 1093787012038 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 1093787012039 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1093787012040 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1093787012041 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1093787012042 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1093787012043 RNA binding surface [nucleotide binding]; other site 1093787012044 Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555 1093787012045 active site 1093787012046 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1093787012047 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1093787012048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787012049 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787012050 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787012051 metal binding site [ion binding]; metal-binding site 1093787012052 active site 1093787012053 I-site; other site 1093787012054 conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001 1093787012055 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1093787012056 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1093787012057 flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688 1093787012058 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1093787012059 Walker A motif/ATP binding site; other site 1093787012060 Walker B motif; other site 1093787012061 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1093787012062 Flagellar assembly protein FliH; Region: FliH; pfam02108 1093787012063 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1093787012064 MgtE intracellular N domain; Region: MgtE_N; smart00924 1093787012065 FliG C-terminal domain; Region: FliG_C; pfam01706 1093787012066 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1093787012067 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1093787012068 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1093787012069 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1093787012070 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1093787012071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787012072 active site 1093787012073 phosphorylation site [posttranslational modification] 1093787012074 intermolecular recognition site; other site 1093787012075 dimerization interface [polypeptide binding]; other site 1093787012076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787012077 Walker A motif; other site 1093787012078 ATP binding site [chemical binding]; other site 1093787012079 Walker B motif; other site 1093787012080 arginine finger; other site 1093787012081 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1093787012082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1093787012083 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787012084 putative active site [active] 1093787012085 heme pocket [chemical binding]; other site 1093787012086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787012087 dimer interface [polypeptide binding]; other site 1093787012088 phosphorylation site [posttranslational modification] 1093787012089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787012090 ATP binding site [chemical binding]; other site 1093787012091 Mg2+ binding site [ion binding]; other site 1093787012092 G-X-G motif; other site 1093787012093 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1093787012094 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 1093787012095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787012096 Walker A motif; other site 1093787012097 ATP binding site [chemical binding]; other site 1093787012098 Walker B motif; other site 1093787012099 arginine finger; other site 1093787012100 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1093787012101 flagellar protein FliS; Validated; Region: fliS; PRK05685 1093787012102 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 1093787012103 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1093787012104 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1093787012105 Uncharacterized flagellar protein FlaG [Cell motility and secretion]; Region: FlaG; COG1334 1093787012106 flagellin; Provisional; Region: PRK12806 1093787012107 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1093787012108 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 1093787012109 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1093787012110 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1093787012111 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1093787012112 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1093787012113 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1093787012114 active site 1093787012115 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1093787012116 Predicted sugar nucleotidyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1213 1093787012117 active site 1093787012118 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1093787012119 Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; Region: HAD-SF-IB; TIGR01488 1093787012120 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1093787012121 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1093787012122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787012123 S-adenosylmethionine binding site [chemical binding]; other site 1093787012124 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 1093787012125 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1093787012126 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1093787012127 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683 1093787012128 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1093787012129 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1093787012130 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1093787012131 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1093787012132 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1093787012133 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1093787012134 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 1093787012135 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1093787012136 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1093787012137 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1093787012138 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1093787012139 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1093787012140 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1093787012141 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1093787012142 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1093787012143 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1093787012144 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1093787012145 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1093787012146 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1093787012147 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1093787012148 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1093787012149 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1093787012150 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1093787012151 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1093787012152 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1093787012153 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1093787012154 Protein of unknown function (DUF2288); Region: DUF2288; cl02399 1093787012155 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1093787012156 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1093787012157 dimerization interface [polypeptide binding]; other site 1093787012158 ligand binding site [chemical binding]; other site 1093787012159 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1093787012160 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1093787012161 TM-ABC transporter signature motif; other site 1093787012162 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1093787012163 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1093787012164 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1093787012165 TM-ABC transporter signature motif; other site 1093787012166 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1093787012167 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1093787012168 Walker A/P-loop; other site 1093787012169 ATP binding site [chemical binding]; other site 1093787012170 Q-loop/lid; other site 1093787012171 ABC transporter signature motif; other site 1093787012172 Walker B; other site 1093787012173 D-loop; other site 1093787012174 H-loop/switch region; other site 1093787012175 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1093787012176 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1093787012177 Walker A/P-loop; other site 1093787012178 ATP binding site [chemical binding]; other site 1093787012179 Q-loop/lid; other site 1093787012180 ABC transporter signature motif; other site 1093787012181 Walker B; other site 1093787012182 D-loop; other site 1093787012183 H-loop/switch region; other site 1093787012184 NMDA receptor-regulated protein 1; Region: NARP1; pfam12569 1093787012185 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 1093787012186 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 1093787012187 ATP binding site [chemical binding]; other site 1093787012188 Mg2+ binding site [ion binding]; other site 1093787012189 G-X-G motif; other site 1093787012190 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787012191 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787012192 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1093787012193 putative effector binding pocket; other site 1093787012194 dimerization interface [polypeptide binding]; other site 1093787012195 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 1093787012196 putative NAD(P) binding site [chemical binding]; other site 1093787012197 homodimer interface [polypeptide binding]; other site 1093787012198 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1093787012199 Predicted membrane protein [Function unknown]; Region: COG3650 1093787012200 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1093787012201 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1093787012202 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1093787012203 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1093787012204 catalytic residue [active] 1093787012205 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1093787012206 EamA-like transporter family; Region: EamA; pfam00892 1093787012207 EamA-like transporter family; Region: EamA; pfam00892 1093787012208 Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320 1093787012209 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 1093787012210 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1093787012211 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 1093787012212 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1093787012213 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 1093787012214 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 1093787012215 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1093787012216 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 1093787012217 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1093787012218 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1093787012219 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1093787012220 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1093787012221 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1093787012222 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1093787012223 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1093787012224 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1093787012225 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1093787012226 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1093787012227 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1093787012228 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1093787012229 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1093787012230 ligand binding site [chemical binding]; other site 1093787012231 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1093787012232 Beta-lactamase; Region: Beta-lactamase; pfam00144 1093787012233 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1093787012234 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1093787012235 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1093787012236 Predicted integral membrane protein [Function unknown]; Region: COG5615 1093787012237 Predicted membrane protein [Function unknown]; Region: COG3776 1093787012238 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1093787012239 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1093787012240 ligand binding site [chemical binding]; other site 1093787012241 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1093787012242 SEC-C motif; Region: SEC-C; pfam02810 1093787012243 hypothetical protein; Provisional; Region: PRK04233 1093787012244 Predicted membrane protein [Function unknown]; Region: COG2860 1093787012245 UPF0126 domain; Region: UPF0126; pfam03458 1093787012246 UPF0126 domain; Region: UPF0126; pfam03458 1093787012247 LEA14-like dessication related protein [Defense mechanisms]; Region: COG5608 1093787012248 Water Stress and Hypersensitive response; Region: WHy; smart00769 1093787012249 SEC-C motif; Region: SEC-C; pfam02810 1093787012250 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1093787012251 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1093787012252 C-terminal domain interface [polypeptide binding]; other site 1093787012253 GSH binding site (G-site) [chemical binding]; other site 1093787012254 dimer interface [polypeptide binding]; other site 1093787012255 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1093787012256 N-terminal domain interface [polypeptide binding]; other site 1093787012257 putative dimer interface [polypeptide binding]; other site 1093787012258 active site 1093787012259 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1093787012260 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1093787012261 active site 1093787012262 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 1093787012263 RmuC family; Region: RmuC; pfam02646 1093787012264 RES domain; Region: RES; smart00953 1093787012265 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1093787012266 salt bridge; other site 1093787012267 sequence-specific DNA binding site [nucleotide binding]; other site 1093787012268 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1093787012269 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1093787012270 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1093787012271 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1093787012272 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1093787012273 tetrameric interface [polypeptide binding]; other site 1093787012274 NAD binding site [chemical binding]; other site 1093787012275 catalytic residues [active] 1093787012276 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1093787012277 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 1093787012278 outer membrane porin, OprD family; Region: OprD; pfam03573 1093787012279 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1093787012280 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1093787012281 FMN binding site [chemical binding]; other site 1093787012282 substrate binding site [chemical binding]; other site 1093787012283 putative catalytic residue [active] 1093787012284 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1093787012285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787012286 NAD(P) binding site [chemical binding]; other site 1093787012287 active site 1093787012288 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1093787012289 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787012290 active site 1093787012291 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1093787012292 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1093787012293 substrate binding site [chemical binding]; other site 1093787012294 oxyanion hole (OAH) forming residues; other site 1093787012295 trimer interface [polypeptide binding]; other site 1093787012296 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787012297 active site 1093787012298 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1093787012299 CoenzymeA binding site [chemical binding]; other site 1093787012300 subunit interaction site [polypeptide binding]; other site 1093787012301 PHB binding site; other site 1093787012302 benzoate transport; Region: 2A0115; TIGR00895 1093787012303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787012304 putative substrate translocation pore; other site 1093787012305 enoyl-CoA hydratase; Region: PLN02864 1093787012306 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1093787012307 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1093787012308 dimer interaction site [polypeptide binding]; other site 1093787012309 substrate-binding tunnel; other site 1093787012310 active site 1093787012311 catalytic site [active] 1093787012312 substrate binding site [chemical binding]; other site 1093787012313 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1093787012314 CoA binding domain; Region: CoA_binding_2; pfam13380 1093787012315 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1093787012316 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1093787012317 thiolase; Provisional; Region: PRK06158 1093787012318 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1093787012319 active site 1093787012320 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1093787012321 DUF35 OB-fold domain; Region: DUF35; pfam01796 1093787012322 potential frameshift: common BLAST hit: gi|116054438|ref|YP_792256.1| putative transcriptional regulator 1093787012323 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1093787012324 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1093787012325 active site 1093787012326 integrase; Provisional; Region: int; PHA02601 1093787012327 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1093787012328 active site 1093787012329 DNA binding site [nucleotide binding] 1093787012330 Int/Topo IB signature motif; other site 1093787012331 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1093787012332 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1093787012333 ATP binding site [chemical binding]; other site 1093787012334 active site 1093787012335 substrate binding site [chemical binding]; other site 1093787012336 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1093787012337 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 1093787012338 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1093787012339 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1093787012340 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1093787012341 dimer interface [polypeptide binding]; other site 1093787012342 active site 1093787012343 catalytic residue [active] 1093787012344 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1093787012345 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1093787012346 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1093787012347 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1093787012348 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1093787012349 catalytic triad [active] 1093787012350 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1093787012351 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1093787012352 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1093787012353 CPxP motif; other site 1093787012354 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1093787012355 Peptidase family M48; Region: Peptidase_M48; cl12018 1093787012356 quinolinate synthetase; Provisional; Region: PRK09375 1093787012357 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787012358 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787012359 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1093787012360 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1093787012361 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1093787012362 glutamine binding [chemical binding]; other site 1093787012363 catalytic triad [active] 1093787012364 anthranilate synthase component I; Provisional; Region: PRK13564 1093787012365 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1093787012366 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1093787012367 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1093787012368 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1093787012369 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1093787012370 dimer interface [polypeptide binding]; other site 1093787012371 active site 1093787012372 CoA binding pocket [chemical binding]; other site 1093787012373 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1093787012374 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1093787012375 active site 1093787012376 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1093787012377 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1093787012378 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1093787012379 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 1093787012380 dimer interface [polypeptide binding]; other site 1093787012381 acyl-activating enzyme (AAE) consensus motif; other site 1093787012382 putative active site [active] 1093787012383 putative AMP binding site [chemical binding]; other site 1093787012384 putative CoA binding site [chemical binding]; other site 1093787012385 chemical substrate binding site [chemical binding]; other site 1093787012386 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1093787012387 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1093787012388 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1093787012389 DNA binding site [nucleotide binding] 1093787012390 active site 1093787012391 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1093787012392 PapC N-terminal domain; Region: PapC_N; pfam13954 1093787012393 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1093787012394 PapC C-terminal domain; Region: PapC_C; pfam13953 1093787012395 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1093787012396 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1093787012397 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1093787012398 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1093787012399 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 1093787012400 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1093787012401 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1093787012402 nudix motif; other site 1093787012403 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1093787012404 active site 1093787012405 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1093787012406 Ligand Binding Site [chemical binding]; other site 1093787012407 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 1093787012408 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1093787012409 FeS/SAM binding site; other site 1093787012410 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1093787012411 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1093787012412 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1093787012413 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1093787012414 ligand binding site [chemical binding]; other site 1093787012415 translocation protein TolB; Provisional; Region: tolB; PRK00178 1093787012416 TolB amino-terminal domain; Region: TolB_N; pfam04052 1093787012417 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1093787012418 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1093787012419 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1093787012420 TolA protein; Region: tolA_full; TIGR02794 1093787012421 TolA protein; Region: tolA_full; TIGR02794 1093787012422 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1093787012423 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1093787012424 TolR protein; Region: tolR; TIGR02801 1093787012425 TolQ protein; Region: tolQ; TIGR02796 1093787012426 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1093787012427 active site 1093787012428 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1093787012429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787012430 Walker A motif; other site 1093787012431 ATP binding site [chemical binding]; other site 1093787012432 Walker B motif; other site 1093787012433 arginine finger; other site 1093787012434 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1093787012435 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1093787012436 RuvA N terminal domain; Region: RuvA_N; pfam01330 1093787012437 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1093787012438 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1093787012439 dimer interface [polypeptide binding]; other site 1093787012440 active site 1093787012441 putative DNA-binding cleft [nucleotide binding]; other site 1093787012442 hypothetical protein; Validated; Region: PRK00110 1093787012443 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1093787012444 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1093787012445 dimer interface [polypeptide binding]; other site 1093787012446 anticodon binding site; other site 1093787012447 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1093787012448 homodimer interface [polypeptide binding]; other site 1093787012449 motif 1; other site 1093787012450 active site 1093787012451 motif 2; other site 1093787012452 GAD domain; Region: GAD; pfam02938 1093787012453 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1093787012454 active site 1093787012455 motif 3; other site 1093787012456 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1093787012457 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1093787012458 dimerization interface [polypeptide binding]; other site 1093787012459 DPS ferroxidase diiron center [ion binding]; other site 1093787012460 ion pore; other site 1093787012461 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1093787012462 DNA-binding site [nucleotide binding]; DNA binding site 1093787012463 RNA-binding motif; other site 1093787012464 hypothetical protein; Provisional; Region: PRK00295 1093787012465 HIT domain; Region: HIT; pfam01230 1093787012466 nucleotide binding site/active site [active] 1093787012467 HIT family signature motif; other site 1093787012468 catalytic residue [active] 1093787012469 outer membrane porin, OprD family; Region: OprD; pfam03573 1093787012470 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1093787012471 CoenzymeA binding site [chemical binding]; other site 1093787012472 subunit interaction site [polypeptide binding]; other site 1093787012473 PHB binding site; other site 1093787012474 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1093787012475 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1093787012476 dimer interface [polypeptide binding]; other site 1093787012477 motif 1; other site 1093787012478 active site 1093787012479 motif 2; other site 1093787012480 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1093787012481 putative deacylase active site [active] 1093787012482 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1093787012483 active site 1093787012484 motif 3; other site 1093787012485 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1093787012486 anticodon binding site; other site 1093787012487 acylphosphatase; Provisional; Region: PRK14442 1093787012488 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1093787012489 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1093787012490 catalytic residues [active] 1093787012491 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1093787012492 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1093787012493 ArsC family; Region: ArsC; pfam03960 1093787012494 catalytic residues [active] 1093787012495 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1093787012496 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1093787012497 Predicted membrane protein [Function unknown]; Region: COG3308 1093787012498 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1093787012499 DNA replication initiation factor; Validated; Region: PRK05642 1093787012500 Walker A motif; other site 1093787012501 ATP binding site [chemical binding]; other site 1093787012502 Walker B motif; other site 1093787012503 arginine finger; other site 1093787012504 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3249 1093787012505 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 1093787012506 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1093787012507 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1093787012508 dimerization interface [polypeptide binding]; other site 1093787012509 putative ATP binding site [chemical binding]; other site 1093787012510 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1093787012511 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1093787012512 active site 1093787012513 substrate binding site [chemical binding]; other site 1093787012514 cosubstrate binding site; other site 1093787012515 catalytic site [active] 1093787012516 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1093787012517 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1093787012518 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1093787012519 MarR family; Region: MarR_2; cl17246 1093787012520 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 1093787012521 Domain of unknown function (DUF2024); Region: DUF2024; pfam09630 1093787012522 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 1093787012523 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 1093787012524 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 1093787012525 potential frameshift: common BLAST hit: gi|218893095|ref|YP_002441964.1| lipopolysaccharide biosynthetic protein LpxO2 1093787012526 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1093787012527 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1093787012528 homodimer interface [polypeptide binding]; other site 1093787012529 metal binding site [ion binding]; metal-binding site 1093787012530 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1093787012531 homodimer interface [polypeptide binding]; other site 1093787012532 active site 1093787012533 putative chemical substrate binding site [chemical binding]; other site 1093787012534 metal binding site [ion binding]; metal-binding site 1093787012535 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1093787012536 HD domain; Region: HD_4; pfam13328 1093787012537 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1093787012538 synthetase active site [active] 1093787012539 NTP binding site [chemical binding]; other site 1093787012540 metal binding site [ion binding]; metal-binding site 1093787012541 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1093787012542 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1093787012543 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1093787012544 TRAM domain; Region: TRAM; pfam01938 1093787012545 cysteine synthase B; Region: cysM; TIGR01138 1093787012546 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1093787012547 dimer interface [polypeptide binding]; other site 1093787012548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787012549 catalytic residue [active] 1093787012550 outer membrane receptor FepA; Provisional; Region: PRK13528 1093787012551 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787012552 N-terminal plug; other site 1093787012553 ligand-binding site [chemical binding]; other site 1093787012554 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1093787012555 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787012556 dimerization interface [polypeptide binding]; other site 1093787012557 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787012558 dimer interface [polypeptide binding]; other site 1093787012559 phosphorylation site [posttranslational modification] 1093787012560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787012561 ATP binding site [chemical binding]; other site 1093787012562 G-X-G motif; other site 1093787012563 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1093787012564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787012565 active site 1093787012566 phosphorylation site [posttranslational modification] 1093787012567 intermolecular recognition site; other site 1093787012568 dimerization interface [polypeptide binding]; other site 1093787012569 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787012570 DNA binding site [nucleotide binding] 1093787012571 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1093787012572 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787012573 dimerization interface [polypeptide binding]; other site 1093787012574 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787012575 dimer interface [polypeptide binding]; other site 1093787012576 phosphorylation site [posttranslational modification] 1093787012577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787012578 ATP binding site [chemical binding]; other site 1093787012579 Mg2+ binding site [ion binding]; other site 1093787012580 G-X-G motif; other site 1093787012581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787012582 active site 1093787012583 phosphorylation site [posttranslational modification] 1093787012584 intermolecular recognition site; other site 1093787012585 dimerization interface [polypeptide binding]; other site 1093787012586 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1093787012587 putative binding surface; other site 1093787012588 active site 1093787012589 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1093787012590 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1093787012591 putative ligand binding site [chemical binding]; other site 1093787012592 putative NAD binding site [chemical binding]; other site 1093787012593 catalytic site [active] 1093787012594 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 1093787012595 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1093787012596 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1093787012597 Sulfatase; Region: Sulfatase; cl17466 1093787012598 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1093787012599 active site 1093787012600 DNA polymerase IV; Validated; Region: PRK02406 1093787012601 DNA binding site [nucleotide binding] 1093787012602 Replication protein A C terminal; Region: RPA_C; pfam08784 1093787012603 Predicted integral membrane protein [Function unknown]; Region: COG0392 1093787012604 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1093787012605 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1093787012606 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 1093787012607 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 1093787012608 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1093787012609 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1093787012610 potassium uptake protein; Region: kup; TIGR00794 1093787012611 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1093787012612 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1093787012613 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1093787012614 FeS/SAM binding site; other site 1093787012615 TRAM domain; Region: TRAM; pfam01938 1093787012616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1093787012617 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1093787012618 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1093787012619 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1093787012620 MgtE intracellular N domain; Region: MgtE_N; smart00924 1093787012621 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1093787012622 Divalent cation transporter; Region: MgtE; pfam01769 1093787012623 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1093787012624 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1093787012625 Protein of unknown function (DUF754); Region: DUF754; pfam05449 1093787012626 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1093787012627 non-specific DNA binding site [nucleotide binding]; other site 1093787012628 Predicted transcriptional regulator [Transcription]; Region: COG2932 1093787012629 salt bridge; other site 1093787012630 sequence-specific DNA binding site [nucleotide binding]; other site 1093787012631 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1093787012632 Catalytic site [active] 1093787012633 carbon storage regulator; Provisional; Region: PRK01712 1093787012634 aspartate kinase; Reviewed; Region: PRK06635 1093787012635 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1093787012636 putative nucleotide binding site [chemical binding]; other site 1093787012637 putative catalytic residues [active] 1093787012638 putative Mg ion binding site [ion binding]; other site 1093787012639 putative aspartate binding site [chemical binding]; other site 1093787012640 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1093787012641 putative allosteric regulatory site; other site 1093787012642 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1093787012643 putative allosteric regulatory residue; other site 1093787012644 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1093787012645 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1093787012646 motif 1; other site 1093787012647 active site 1093787012648 motif 2; other site 1093787012649 motif 3; other site 1093787012650 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1093787012651 DHHA1 domain; Region: DHHA1; pfam02272 1093787012652 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1093787012653 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1093787012654 tetramer interface [polypeptide binding]; other site 1093787012655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787012656 catalytic residue [active] 1093787012657 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1093787012658 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1093787012659 putative active site [active] 1093787012660 Zn binding site [ion binding]; other site 1093787012661 succinylarginine dihydrolase; Provisional; Region: PRK13281 1093787012662 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1093787012663 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1093787012664 NAD(P) binding site [chemical binding]; other site 1093787012665 catalytic residues [active] 1093787012666 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1093787012667 arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244 1093787012668 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1093787012669 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1093787012670 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1093787012671 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1093787012672 inhibitor-cofactor binding pocket; inhibition site 1093787012673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787012674 catalytic residue [active] 1093787012675 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1093787012676 conserved cys residue [active] 1093787012677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787012678 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787012679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787012680 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1093787012681 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1093787012682 Walker A/P-loop; other site 1093787012683 ATP binding site [chemical binding]; other site 1093787012684 Q-loop/lid; other site 1093787012685 ABC transporter signature motif; other site 1093787012686 Walker B; other site 1093787012687 D-loop; other site 1093787012688 H-loop/switch region; other site 1093787012689 Predicted deacylase [General function prediction only]; Region: COG3608 1093787012690 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1093787012691 active site 1093787012692 Zn binding site [ion binding]; other site 1093787012693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787012694 dimer interface [polypeptide binding]; other site 1093787012695 conserved gate region; other site 1093787012696 putative PBP binding loops; other site 1093787012697 ABC-ATPase subunit interface; other site 1093787012698 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1093787012699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787012700 dimer interface [polypeptide binding]; other site 1093787012701 conserved gate region; other site 1093787012702 putative PBP binding loops; other site 1093787012703 ABC-ATPase subunit interface; other site 1093787012704 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1093787012705 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787012706 substrate binding pocket [chemical binding]; other site 1093787012707 membrane-bound complex binding site; other site 1093787012708 hinge residues; other site 1093787012709 acetyl-CoA synthetase; Provisional; Region: PRK00174 1093787012710 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1093787012711 active site 1093787012712 CoA binding site [chemical binding]; other site 1093787012713 acyl-activating enzyme (AAE) consensus motif; other site 1093787012714 AMP binding site [chemical binding]; other site 1093787012715 acetate binding site [chemical binding]; other site 1093787012716 DctM-like transporters; Region: DctM; pfam06808 1093787012717 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1093787012718 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1093787012719 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1093787012720 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1093787012721 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1093787012722 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1093787012723 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1093787012724 MmgE/PrpD family; Region: MmgE_PrpD; pfam03972 1093787012725 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1093787012726 dimer interface [polypeptide binding]; other site 1093787012727 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1093787012728 metal binding site [ion binding]; metal-binding site 1093787012729 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1093787012730 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787012731 active site 1093787012732 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1093787012733 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1093787012734 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1093787012735 active site 2 [active] 1093787012736 active site 1 [active] 1093787012737 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787012738 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787012739 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1093787012740 putative dimerization interface [polypeptide binding]; other site 1093787012741 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787012742 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787012743 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1093787012744 putative effector binding pocket; other site 1093787012745 dimerization interface [polypeptide binding]; other site 1093787012746 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1093787012747 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1093787012748 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 1093787012749 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1093787012750 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 1093787012751 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1093787012752 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787012753 putative active site [active] 1093787012754 heme pocket [chemical binding]; other site 1093787012755 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787012756 Walker A motif; other site 1093787012757 ATP binding site [chemical binding]; other site 1093787012758 Walker B motif; other site 1093787012759 arginine finger; other site 1093787012760 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 1093787012761 cofactor binding site; other site 1093787012762 metal binding site [ion binding]; metal-binding site 1093787012763 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 1093787012764 aromatic arch; other site 1093787012765 DCoH dimer interaction site [polypeptide binding]; other site 1093787012766 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1093787012767 DCoH tetramer interaction site [polypeptide binding]; other site 1093787012768 substrate binding site [chemical binding]; other site 1093787012769 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1093787012770 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1093787012771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787012772 homodimer interface [polypeptide binding]; other site 1093787012773 catalytic residue [active] 1093787012774 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1093787012775 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1093787012776 hypothetical protein; Provisional; Region: PRK09256 1093787012777 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1093787012778 lysozyme inhibitor; Provisional; Region: PRK13792 1093787012779 Predicted periplasmic protein [General function prediction only]; Region: COG3895 1093787012780 aromatic amino acid transporter; Provisional; Region: PRK10238 1093787012781 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1093787012782 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1093787012783 dimer interface [polypeptide binding]; other site 1093787012784 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1093787012785 active site 1093787012786 Fe binding site [ion binding]; other site 1093787012787 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1093787012788 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1093787012789 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787012790 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787012791 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 1093787012792 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1093787012793 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1093787012794 putative NAD(P) binding site [chemical binding]; other site 1093787012795 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 1093787012796 PAS domain S-box; Region: sensory_box; TIGR00229 1093787012797 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787012798 putative active site [active] 1093787012799 heme pocket [chemical binding]; other site 1093787012800 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787012801 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787012802 metal binding site [ion binding]; metal-binding site 1093787012803 active site 1093787012804 I-site; other site 1093787012805 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1093787012806 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1093787012807 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787012808 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1093787012809 Walker A/P-loop; other site 1093787012810 ATP binding site [chemical binding]; other site 1093787012811 Q-loop/lid; other site 1093787012812 ABC transporter signature motif; other site 1093787012813 Walker B; other site 1093787012814 D-loop; other site 1093787012815 H-loop/switch region; other site 1093787012816 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1093787012817 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1093787012818 catalytic residues [active] 1093787012819 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 1093787012820 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1093787012821 active site residue [active] 1093787012822 BolA-like protein; Region: BolA; cl00386 1093787012823 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 1093787012824 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 1093787012825 fumarate hydratase; Provisional; Region: PRK12425 1093787012826 Class II fumarases; Region: Fumarase_classII; cd01362 1093787012827 active site 1093787012828 tetramer interface [polypeptide binding]; other site 1093787012829 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1093787012830 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1093787012831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 1093787012832 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1093787012833 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1093787012834 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1093787012835 tetramer interface [polypeptide binding]; other site 1093787012836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787012837 catalytic residue [active] 1093787012838 MAPEG family; Region: MAPEG; pfam01124 1093787012839 thioredoxin reductase; Provisional; Region: PRK10262 1093787012840 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1093787012841 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1093787012842 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1093787012843 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1093787012844 dimer interface [polypeptide binding]; other site 1093787012845 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1093787012846 catalytic triad [active] 1093787012847 peroxidatic and resolving cysteines [active] 1093787012848 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322 1093787012849 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787012850 dimerization interface [polypeptide binding]; other site 1093787012851 PAS domain S-box; Region: sensory_box; TIGR00229 1093787012852 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787012853 putative active site [active] 1093787012854 heme pocket [chemical binding]; other site 1093787012855 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787012856 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787012857 metal binding site [ion binding]; metal-binding site 1093787012858 active site 1093787012859 I-site; other site 1093787012860 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1093787012861 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 1093787012862 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1093787012863 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1093787012864 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1093787012865 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1093787012866 phospholipase C accessory protein PlcR; Region: plc_access_R; TIGR03398 1093787012867 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1093787012868 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1093787012869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1093787012870 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1093787012871 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1093787012872 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 1093787012873 putative active site [active] 1093787012874 putative FMN binding site [chemical binding]; other site 1093787012875 putative substrate binding site [chemical binding]; other site 1093787012876 putative catalytic residue [active] 1093787012877 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787012878 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787012879 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1093787012880 catalytic residues [active] 1093787012881 dimer interface [polypeptide binding]; other site 1093787012882 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 1093787012883 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1093787012884 Protein of unknown function (DUF3565); Region: DUF3565; pfam12088 1093787012885 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1093787012886 propionate/acetate kinase; Provisional; Region: PRK12379 1093787012887 phosphate acetyltransferase; Reviewed; Region: PRK05632 1093787012888 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1093787012889 DRTGG domain; Region: DRTGG; pfam07085 1093787012890 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1093787012891 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1093787012892 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1093787012893 putative acyl-acceptor binding pocket; other site 1093787012894 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1093787012895 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1093787012896 ligand binding site [chemical binding]; other site 1093787012897 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1093787012898 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1093787012899 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787012900 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787012901 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1093787012902 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1093787012903 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1093787012904 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1093787012905 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1093787012906 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787012907 HTH-like domain; Region: HTH_21; pfam13276 1093787012908 Integrase core domain; Region: rve; pfam00665 1093787012909 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1093787012910 Integrase core domain; Region: rve_3; pfam13683 1093787012911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1093787012912 Transposase; Region: HTH_Tnp_1; pfam01527 1093787012913 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 1093787012914 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1093787012915 putative metal binding site [ion binding]; other site 1093787012916 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787012917 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787012918 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 1093787012919 putative dimerization interface [polypeptide binding]; other site 1093787012920 cell density-dependent motility repressor; Provisional; Region: PRK10082 1093787012921 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787012922 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1093787012923 dimerization interface [polypeptide binding]; other site 1093787012924 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1093787012925 homotrimer interaction site [polypeptide binding]; other site 1093787012926 putative active site [active] 1093787012927 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1093787012928 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1093787012929 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1093787012930 catalytic residue [active] 1093787012931 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 1093787012932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787012933 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1093787012934 putative substrate translocation pore; other site 1093787012935 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1093787012936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1093787012937 motif II; other site 1093787012938 manganese transport protein MntH; Reviewed; Region: PRK00701 1093787012939 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1093787012940 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 1093787012941 putative hydrophobic ligand binding site [chemical binding]; other site 1093787012942 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1093787012943 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1093787012944 amidase catalytic site [active] 1093787012945 Zn binding residues [ion binding]; other site 1093787012946 substrate binding site [chemical binding]; other site 1093787012947 Predicted membrane protein [Function unknown]; Region: COG4270 1093787012948 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1093787012949 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1093787012950 active site 1093787012951 catalytic tetrad [active] 1093787012952 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1093787012953 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1093787012954 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 1093787012955 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1093787012956 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1093787012957 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1093787012958 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1093787012959 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1093787012960 ATP binding site [chemical binding]; other site 1093787012961 putative Mg++ binding site [ion binding]; other site 1093787012962 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1093787012963 nucleotide binding region [chemical binding]; other site 1093787012964 ATP-binding site [chemical binding]; other site 1093787012965 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1093787012966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787012967 S-adenosylmethionine binding site [chemical binding]; other site 1093787012968 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1093787012969 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787012970 DNA-binding site [nucleotide binding]; DNA binding site 1093787012971 FCD domain; Region: FCD; pfam07729 1093787012972 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1093787012973 tetramer interface [polypeptide binding]; other site 1093787012974 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1093787012975 active site 1093787012976 Mg2+/Mn2+ binding site [ion binding]; other site 1093787012977 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1093787012978 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 1093787012979 dimer interface [polypeptide binding]; other site 1093787012980 active site 1093787012981 citrylCoA binding site [chemical binding]; other site 1093787012982 oxalacetate/citrate binding site [chemical binding]; other site 1093787012983 coenzyme A binding site [chemical binding]; other site 1093787012984 catalytic triad [active] 1093787012985 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 1093787012986 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1093787012987 substrate binding site [chemical binding]; other site 1093787012988 ligand binding site [chemical binding]; other site 1093787012989 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1093787012990 substrate binding site [chemical binding]; other site 1093787012991 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 1093787012992 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1093787012993 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1093787012994 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1093787012995 Helix-turn-helix domain; Region: HTH_18; pfam12833 1093787012996 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787012997 Predicted permeases [General function prediction only]; Region: COG0730 1093787012998 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1093787012999 Spore germination protein; Region: Spore_permease; cl17796 1093787013000 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1093787013001 Transglycosylase; Region: Transgly; cl17702 1093787013002 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1093787013003 Predicted ATPase [General function prediction only]; Region: COG4637 1093787013004 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787013005 Walker A/P-loop; other site 1093787013006 ATP binding site [chemical binding]; other site 1093787013007 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1093787013008 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1093787013009 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1093787013010 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1093787013011 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787013012 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787013013 dimerization interface [polypeptide binding]; other site 1093787013014 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1093787013015 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1093787013016 Na binding site [ion binding]; other site 1093787013017 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 1093787013018 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1093787013019 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1093787013020 Glutamate binding site [chemical binding]; other site 1093787013021 NAD binding site [chemical binding]; other site 1093787013022 catalytic residues [active] 1093787013023 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1093787013024 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787013025 N-terminal plug; other site 1093787013026 ligand-binding site [chemical binding]; other site 1093787013027 Cupin domain; Region: Cupin_2; cl17218 1093787013028 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1093787013029 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787013030 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787013031 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1093787013032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787013033 Walker A motif; other site 1093787013034 ATP binding site [chemical binding]; other site 1093787013035 Walker B motif; other site 1093787013036 arginine finger; other site 1093787013037 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1093787013038 Predicted secreted protein [Function unknown]; Region: COG5513 1093787013039 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 1093787013040 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1093787013041 membrane-bound complex binding site; other site 1093787013042 hinge residues; other site 1093787013043 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1093787013044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787013045 S-adenosylmethionine binding site [chemical binding]; other site 1093787013046 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1093787013047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787013048 S-adenosylmethionine binding site [chemical binding]; other site 1093787013049 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1093787013050 active site 1093787013051 hydrophilic channel; other site 1093787013052 dimerization interface [polypeptide binding]; other site 1093787013053 catalytic residues [active] 1093787013054 active site lid [active] 1093787013055 Recombination protein O N terminal; Region: RecO_N; pfam11967 1093787013056 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1093787013057 Recombination protein O C terminal; Region: RecO_C; pfam02565 1093787013058 GTPase Era; Reviewed; Region: era; PRK00089 1093787013059 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1093787013060 G1 box; other site 1093787013061 GTP/Mg2+ binding site [chemical binding]; other site 1093787013062 Switch I region; other site 1093787013063 G2 box; other site 1093787013064 Switch II region; other site 1093787013065 G3 box; other site 1093787013066 G4 box; other site 1093787013067 G5 box; other site 1093787013068 KH domain; Region: KH_2; pfam07650 1093787013069 ribonuclease III; Reviewed; Region: rnc; PRK00102 1093787013070 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1093787013071 dimerization interface [polypeptide binding]; other site 1093787013072 active site 1093787013073 metal binding site [ion binding]; metal-binding site 1093787013074 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1093787013075 dsRNA binding site [nucleotide binding]; other site 1093787013076 signal peptidase I; Provisional; Region: PRK10861 1093787013077 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1093787013078 Catalytic site [active] 1093787013079 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1093787013080 GTP-binding protein LepA; Provisional; Region: PRK05433 1093787013081 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1093787013082 G1 box; other site 1093787013083 putative GEF interaction site [polypeptide binding]; other site 1093787013084 GTP/Mg2+ binding site [chemical binding]; other site 1093787013085 Switch I region; other site 1093787013086 G2 box; other site 1093787013087 G3 box; other site 1093787013088 Switch II region; other site 1093787013089 G4 box; other site 1093787013090 G5 box; other site 1093787013091 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1093787013092 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1093787013093 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1093787013094 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1093787013095 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1093787013096 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1093787013097 protein binding site [polypeptide binding]; other site 1093787013098 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1093787013099 protein binding site [polypeptide binding]; other site 1093787013100 Positive regulator of sigma E activity [Signal transduction mechanisms]; Region: RseC; COG3086 1093787013101 MucB/RseB family; Region: MucB_RseB; pfam03888 1093787013102 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1093787013103 potential frameshift: common BLAST hit: gi|218893294|ref|YP_002442163.1| anti-sigma factor MucA 1093787013104 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 1093787013105 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1093787013106 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1093787013107 DNA binding residues [nucleotide binding] 1093787013108 L-aspartate oxidase; Provisional; Region: PRK09077 1093787013109 L-aspartate oxidase; Provisional; Region: PRK06175 1093787013110 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1093787013111 Uncharacterized conserved protein [Function unknown]; Region: COG2938 1093787013112 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1093787013113 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1093787013114 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1093787013115 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1093787013116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1093787013117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787013118 dimer interface [polypeptide binding]; other site 1093787013119 phosphorylation site [posttranslational modification] 1093787013120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787013121 ATP binding site [chemical binding]; other site 1093787013122 G-X-G motif; other site 1093787013123 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1093787013124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787013125 active site 1093787013126 phosphorylation site [posttranslational modification] 1093787013127 intermolecular recognition site; other site 1093787013128 dimerization interface [polypeptide binding]; other site 1093787013129 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787013130 DNA binding site [nucleotide binding] 1093787013131 outer membrane porin, OprD family; Region: OprD; pfam03573 1093787013132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1093787013133 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1093787013134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1093787013135 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1093787013136 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1093787013137 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1093787013138 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1093787013139 ligand binding site [chemical binding]; other site 1093787013140 active site 1093787013141 UGI interface [polypeptide binding]; other site 1093787013142 catalytic site [active] 1093787013143 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 1093787013144 VanW like protein; Region: VanW; pfam04294 1093787013145 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1093787013146 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1093787013147 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787013148 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787013149 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1093787013150 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1093787013151 tetrameric interface [polypeptide binding]; other site 1093787013152 NAD binding site [chemical binding]; other site 1093787013153 catalytic residues [active] 1093787013154 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1093787013155 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 1093787013156 substrate binding pocket [chemical binding]; other site 1093787013157 FAD binding site [chemical binding]; other site 1093787013158 catalytic base [active] 1093787013159 enoyl-CoA hydratase; Provisional; Region: PRK09076 1093787013160 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1093787013161 substrate binding site [chemical binding]; other site 1093787013162 oxyanion hole (OAH) forming residues; other site 1093787013163 trimer interface [polypeptide binding]; other site 1093787013164 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1093787013165 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1093787013166 substrate binding site [chemical binding]; other site 1093787013167 oxyanion hole (OAH) forming residues; other site 1093787013168 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1093787013169 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1093787013170 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1093787013171 Ion channel; Region: Ion_trans_2; pfam07885 1093787013172 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1093787013173 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1093787013174 NAD binding site [chemical binding]; other site 1093787013175 substrate binding site [chemical binding]; other site 1093787013176 putative active site [active] 1093787013177 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1093787013178 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1093787013179 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1093787013180 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787013181 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787013182 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1093787013183 dimerization interface [polypeptide binding]; other site 1093787013184 Predicted membrane protein [Function unknown]; Region: COG3776 1093787013185 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 1093787013186 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1093787013187 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1093787013188 RNA binding surface [nucleotide binding]; other site 1093787013189 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1093787013190 active site 1093787013191 uracil binding [chemical binding]; other site 1093787013192 hypothetical protein; Provisional; Region: PRK06132 1093787013193 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1093787013194 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 1093787013195 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1093787013196 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 1093787013197 hypothetical protein; Provisional; Region: PRK13687 1093787013198 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1093787013199 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787013200 Coenzyme A binding pocket [chemical binding]; other site 1093787013201 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1093787013202 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1093787013203 dimer interface [polypeptide binding]; other site 1093787013204 active site 1093787013205 metal binding site [ion binding]; metal-binding site 1093787013206 glutathione binding site [chemical binding]; other site 1093787013207 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1093787013208 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787013209 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787013210 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787013211 dimerization interface [polypeptide binding]; other site 1093787013212 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1093787013213 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1093787013214 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1093787013215 trimer interface [polypeptide binding]; other site 1093787013216 active site 1093787013217 substrate binding site [chemical binding]; other site 1093787013218 CoA binding site [chemical binding]; other site 1093787013219 potential frameshift: common BLAST hit: gi|386060392|ref|YP_005976914.1| putative glycosyl transferase 1093787013220 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1093787013221 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1093787013222 active site 1093787013223 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1093787013224 trimer interface [polypeptide binding]; other site 1093787013225 active site 1093787013226 substrate binding site [chemical binding]; other site 1093787013227 CoA binding site [chemical binding]; other site 1093787013228 amidase; Provisional; Region: PRK07042 1093787013229 Amidase; Region: Amidase; pfam01425 1093787013230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787013231 metabolite-proton symporter; Region: 2A0106; TIGR00883 1093787013232 putative substrate translocation pore; other site 1093787013233 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1093787013234 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1093787013235 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787013236 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787013237 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787013238 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1093787013239 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1093787013240 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1093787013241 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 1093787013242 TonB C terminal; Region: TonB_2; pfam13103 1093787013243 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1093787013244 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1093787013245 Uncharacterized conserved protein [Function unknown]; Region: COG5306 1093787013246 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 1093787013247 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1093787013248 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1093787013249 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1093787013250 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1093787013251 Surface antigen; Region: Bac_surface_Ag; pfam01103 1093787013252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1093787013253 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1093787013254 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 1093787013255 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1093787013256 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1093787013257 type II secretion system protein F; Region: GspF; TIGR02120 1093787013258 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1093787013259 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1093787013260 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1093787013261 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1093787013262 Walker A motif; other site 1093787013263 ATP binding site [chemical binding]; other site 1093787013264 Walker B motif; other site 1093787013265 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1093787013266 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1093787013267 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1093787013268 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 1093787013269 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1093787013270 Type II secretory pathway, component PulM [Intracellular trafficking and secretion]; Region: PulM; COG3149 1093787013271 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 1093787013272 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 1093787013273 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1093787013274 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1093787013275 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1093787013276 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1093787013277 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1093787013278 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1093787013279 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 1093787013280 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 1093787013281 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1093787013282 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1093787013283 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1093787013284 FecR protein; Region: FecR; pfam04773 1093787013285 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1093787013286 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1093787013287 DNA binding residues [nucleotide binding] 1093787013288 Secretin and TonB N terminus short domain; Region: STN; smart00965 1093787013289 TonB C terminal; Region: TonB_2; pfam13103 1093787013290 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1093787013291 heme binding pocket [chemical binding]; other site 1093787013292 heme ligand [chemical binding]; other site 1093787013293 Cell division inhibitor SulA; Region: SulA; cl01880 1093787013294 DNA Polymerase Y-family; Region: PolY_like; cd03468 1093787013295 active site 1093787013296 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1093787013297 DNA binding site [nucleotide binding] 1093787013298 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1093787013299 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1093787013300 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 1093787013301 putative active site [active] 1093787013302 putative PHP Thumb interface [polypeptide binding]; other site 1093787013303 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1093787013304 generic binding surface II; other site 1093787013305 generic binding surface I; other site 1093787013306 exonuclease subunit SbcD; Provisional; Region: PRK10966 1093787013307 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1093787013308 active site 1093787013309 metal binding site [ion binding]; metal-binding site 1093787013310 DNA binding site [nucleotide binding] 1093787013311 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1093787013312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787013313 AAA domain; Region: AAA_23; pfam13476 1093787013314 Walker A/P-loop; other site 1093787013315 ATP binding site [chemical binding]; other site 1093787013316 Q-loop/lid; other site 1093787013317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787013318 ABC transporter signature motif; other site 1093787013319 Walker B; other site 1093787013320 D-loop; other site 1093787013321 H-loop/switch region; other site 1093787013322 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1093787013323 AAA domain; Region: AAA_30; pfam13604 1093787013324 Family description; Region: UvrD_C_2; pfam13538 1093787013325 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1093787013326 Family description; Region: UvrD_C_2; pfam13538 1093787013327 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1093787013328 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1093787013329 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1093787013330 EamA-like transporter family; Region: EamA; pfam00892 1093787013331 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1093787013332 Helix-turn-helix domain; Region: HTH_18; pfam12833 1093787013333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787013334 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1093787013335 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1093787013336 Chromate transporter; Region: Chromate_transp; pfam02417 1093787013337 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1093787013338 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787013339 dimer interface [polypeptide binding]; other site 1093787013340 putative CheW interface [polypeptide binding]; other site 1093787013341 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1093787013342 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1093787013343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787013344 PAS fold; Region: PAS_3; pfam08447 1093787013345 putative active site [active] 1093787013346 heme pocket [chemical binding]; other site 1093787013347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787013348 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1093787013349 putative active site [active] 1093787013350 heme pocket [chemical binding]; other site 1093787013351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787013352 dimer interface [polypeptide binding]; other site 1093787013353 phosphorylation site [posttranslational modification] 1093787013354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787013355 ATP binding site [chemical binding]; other site 1093787013356 Mg2+ binding site [ion binding]; other site 1093787013357 G-X-G motif; other site 1093787013358 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1093787013359 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 1093787013360 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1093787013361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787013362 active site 1093787013363 phosphorylation site [posttranslational modification] 1093787013364 intermolecular recognition site; other site 1093787013365 dimerization interface [polypeptide binding]; other site 1093787013366 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787013367 DNA binding residues [nucleotide binding] 1093787013368 dimerization interface [polypeptide binding]; other site 1093787013369 Predicted membrane protein [Function unknown]; Region: COG4655 1093787013370 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 1093787013371 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 1093787013372 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1093787013373 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1093787013374 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1093787013375 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1093787013376 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1093787013377 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1093787013378 ATP binding site [chemical binding]; other site 1093787013379 Walker A motif; other site 1093787013380 hexamer interface [polypeptide binding]; other site 1093787013381 Walker B motif; other site 1093787013382 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 1093787013383 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1093787013384 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1093787013385 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1093787013386 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1093787013387 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1093787013388 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1093787013389 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 1093787013390 potential frameshift: common BLAST hit: gi|15599503|ref|NP_252997.1| chemotactic transducer PctC 1093787013391 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1093787013392 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1093787013393 Cache domain; Region: Cache_1; pfam02743 1093787013394 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787013395 dimerization interface [polypeptide binding]; other site 1093787013396 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1093787013397 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787013398 dimer interface [polypeptide binding]; other site 1093787013399 putative CheW interface [polypeptide binding]; other site 1093787013400 Vibrio chemotaxis protein N terminus; Region: MCP_N; pfam05581 1093787013401 Cache domain; Region: Cache_1; pfam02743 1093787013402 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787013403 dimerization interface [polypeptide binding]; other site 1093787013404 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1093787013405 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787013406 dimer interface [polypeptide binding]; other site 1093787013407 putative CheW interface [polypeptide binding]; other site 1093787013408 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1093787013409 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1093787013410 Predicted deacetylase [General function prediction only]; Region: COG3233 1093787013411 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1093787013412 putative active site [active] 1093787013413 putative Zn binding site [ion binding]; other site 1093787013414 Predicted integral membrane protein [Function unknown]; Region: COG0392 1093787013415 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1093787013416 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1093787013417 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1093787013418 putative active site [active] 1093787013419 putative substrate binding site [chemical binding]; other site 1093787013420 putative cosubstrate binding site; other site 1093787013421 catalytic site [active] 1093787013422 exonuclease I; Provisional; Region: sbcB; PRK11779 1093787013423 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1093787013424 active site 1093787013425 catalytic site [active] 1093787013426 substrate binding site [chemical binding]; other site 1093787013427 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1093787013428 Protein of unknown function (DUF975); Region: DUF975; cl10504 1093787013429 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1093787013430 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1093787013431 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1093787013432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787013433 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1093787013434 Walker A motif; other site 1093787013435 ATP binding site [chemical binding]; other site 1093787013436 Walker B motif; other site 1093787013437 arginine finger; other site 1093787013438 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1093787013439 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1093787013440 metal ion-dependent adhesion site (MIDAS); other site 1093787013441 PilZ domain; Region: PilZ; pfam07238 1093787013442 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1093787013443 universal stress protein UspE; Provisional; Region: PRK11175 1093787013444 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1093787013445 Ligand Binding Site [chemical binding]; other site 1093787013446 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1093787013447 Ligand Binding Site [chemical binding]; other site 1093787013448 pyruvate kinase; Provisional; Region: PRK05826 1093787013449 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1093787013450 domain interfaces; other site 1093787013451 active site 1093787013452 enoyl-CoA hydratase; Provisional; Region: PRK06688 1093787013453 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1093787013454 substrate binding site [chemical binding]; other site 1093787013455 oxyanion hole (OAH) forming residues; other site 1093787013456 trimer interface [polypeptide binding]; other site 1093787013457 hypothetical protein; Provisional; Region: PRK05713 1093787013458 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1093787013459 catalytic loop [active] 1093787013460 iron binding site [ion binding]; other site 1093787013461 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1093787013462 FAD binding pocket [chemical binding]; other site 1093787013463 conserved FAD binding motif [chemical binding]; other site 1093787013464 phosphate binding motif [ion binding]; other site 1093787013465 beta-alpha-beta structure motif; other site 1093787013466 NAD binding pocket [chemical binding]; other site 1093787013467 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787013468 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787013469 metal binding site [ion binding]; metal-binding site 1093787013470 active site 1093787013471 I-site; other site 1093787013472 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1093787013473 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1093787013474 manganese transport protein MntH; Reviewed; Region: PRK00701 1093787013475 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1093787013476 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 1093787013477 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1093787013478 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1093787013479 conserved cys residue [active] 1093787013480 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 1093787013481 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1093787013482 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1093787013483 PLD-like domain; Region: PLDc_2; pfam13091 1093787013484 putative active site [active] 1093787013485 catalytic site [active] 1093787013486 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1093787013487 PLD-like domain; Region: PLDc_2; pfam13091 1093787013488 putative active site [active] 1093787013489 catalytic site [active] 1093787013490 YceI-like domain; Region: YceI; pfam04264 1093787013491 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1093787013492 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1093787013493 amidase; Provisional; Region: PRK07486 1093787013494 Amidase; Region: Amidase; pfam01425 1093787013495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787013496 metabolite-proton symporter; Region: 2A0106; TIGR00883 1093787013497 putative substrate translocation pore; other site 1093787013498 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1093787013499 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1093787013500 metal binding site [ion binding]; metal-binding site 1093787013501 putative dimer interface [polypeptide binding]; other site 1093787013502 YceI-like domain; Region: YceI; pfam04264 1093787013503 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1093787013504 Beta-lactamase; Region: Beta-lactamase; pfam00144 1093787013505 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1093787013506 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1093787013507 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787013508 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1093787013509 active site 1093787013510 Putative hemolysin [General function prediction only]; Region: COG3176 1093787013511 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1093787013512 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1093787013513 putative acyl-acceptor binding pocket; other site 1093787013514 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1093787013515 Ligand Binding Site [chemical binding]; other site 1093787013516 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1093787013517 Ligand Binding Site [chemical binding]; other site 1093787013518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3124 1093787013519 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1093787013520 dimerization interface [polypeptide binding]; other site 1093787013521 putative DNA binding site [nucleotide binding]; other site 1093787013522 putative Zn2+ binding site [ion binding]; other site 1093787013523 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1093787013524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787013525 putative substrate translocation pore; other site 1093787013526 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1093787013527 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1093787013528 FMN binding site [chemical binding]; other site 1093787013529 active site 1093787013530 substrate binding site [chemical binding]; other site 1093787013531 catalytic residue [active] 1093787013532 FeoC like transcriptional regulator; Region: FeoC; cl17677 1093787013533 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1093787013534 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1093787013535 G1 box; other site 1093787013536 GTP/Mg2+ binding site [chemical binding]; other site 1093787013537 Switch I region; other site 1093787013538 G2 box; other site 1093787013539 G3 box; other site 1093787013540 Switch II region; other site 1093787013541 G4 box; other site 1093787013542 G5 box; other site 1093787013543 Nucleoside recognition; Region: Gate; pfam07670 1093787013544 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1093787013545 Nucleoside recognition; Region: Gate; pfam07670 1093787013546 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 1093787013547 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1093787013548 oligomer interface [polypeptide binding]; other site 1093787013549 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1093787013550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787013551 NAD(P) binding site [chemical binding]; other site 1093787013552 active site 1093787013553 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1093787013554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787013555 NAD(P) binding site [chemical binding]; other site 1093787013556 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1093787013557 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787013558 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787013559 dimerization interface [polypeptide binding]; other site 1093787013560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 1093787013561 ACT domain; Region: ACT_3; pfam10000 1093787013562 Lysine efflux permease [General function prediction only]; Region: COG1279 1093787013563 superoxide dismutase; Provisional; Region: PRK10543 1093787013564 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1093787013565 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1093787013566 biofilm formation regulator HmsP; Provisional; Region: PRK11829 1093787013567 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787013568 metal binding site [ion binding]; metal-binding site 1093787013569 active site 1093787013570 I-site; other site 1093787013571 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1093787013572 E3 Ubiquitin ligase; Region: GIDE; pfam12483 1093787013573 LemA family; Region: LemA; pfam04011 1093787013574 Imelysin; Region: Peptidase_M75; cl09159 1093787013575 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1093787013576 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 1093787013577 Imelysin; Region: Peptidase_M75; cl09159 1093787013578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 1093787013579 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1093787013580 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787013581 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787013582 multidrug efflux protein; Reviewed; Region: PRK09579 1093787013583 Protein export membrane protein; Region: SecD_SecF; cl14618 1093787013584 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1093787013585 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1093787013586 active site 1093787013587 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293 1093787013588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787013589 S-adenosylmethionine binding site [chemical binding]; other site 1093787013590 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1093787013591 HAMP domain; Region: HAMP; pfam00672 1093787013592 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787013593 dimer interface [polypeptide binding]; other site 1093787013594 phosphorylation site [posttranslational modification] 1093787013595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787013596 ATP binding site [chemical binding]; other site 1093787013597 Mg2+ binding site [ion binding]; other site 1093787013598 G-X-G motif; other site 1093787013599 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1093787013600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787013601 active site 1093787013602 phosphorylation site [posttranslational modification] 1093787013603 intermolecular recognition site; other site 1093787013604 dimerization interface [polypeptide binding]; other site 1093787013605 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787013606 DNA binding site [nucleotide binding] 1093787013607 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1093787013608 active site 1093787013609 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1093787013610 chromosome condensation membrane protein; Provisional; Region: PRK14196 1093787013611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4318 1093787013612 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1093787013613 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1093787013614 ring oligomerisation interface [polypeptide binding]; other site 1093787013615 ATP/Mg binding site [chemical binding]; other site 1093787013616 stacking interactions; other site 1093787013617 hinge regions; other site 1093787013618 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1093787013619 oligomerisation interface [polypeptide binding]; other site 1093787013620 mobile loop; other site 1093787013621 roof hairpin; other site 1093787013622 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1093787013623 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 1093787013624 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 1093787013625 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1093787013626 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1093787013627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787013628 NAD(P) binding site [chemical binding]; other site 1093787013629 active site 1093787013630 Protein of unknown function, DUF481; Region: DUF481; pfam04338 1093787013631 Protein of unknown function, DUF481; Region: DUF481; cl01213 1093787013632 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1093787013633 DNA binding site [nucleotide binding] 1093787013634 active site 1093787013635 AmpG-like permease; Region: 2A0125; TIGR00901 1093787013636 muropeptide transporter; Validated; Region: ampG; cl17669 1093787013637 mechanosensitive channel MscS; Provisional; Region: PRK10334 1093787013638 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1093787013639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1093787013640 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1093787013641 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1093787013642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787013643 active site 1093787013644 phosphorylation site [posttranslational modification] 1093787013645 intermolecular recognition site; other site 1093787013646 dimerization interface [polypeptide binding]; other site 1093787013647 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1093787013648 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1093787013649 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 1093787013650 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1093787013651 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787013652 dimerization interface [polypeptide binding]; other site 1093787013653 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1093787013654 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787013655 putative active site [active] 1093787013656 heme pocket [chemical binding]; other site 1093787013657 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787013658 dimer interface [polypeptide binding]; other site 1093787013659 phosphorylation site [posttranslational modification] 1093787013660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787013661 ATP binding site [chemical binding]; other site 1093787013662 Mg2+ binding site [ion binding]; other site 1093787013663 G-X-G motif; other site 1093787013664 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1093787013665 hypothetical protein; Provisional; Region: PRK08999 1093787013666 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1093787013667 active site 1093787013668 8-oxo-dGMP binding site [chemical binding]; other site 1093787013669 nudix motif; other site 1093787013670 metal binding site [ion binding]; metal-binding site 1093787013671 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1093787013672 thiamine phosphate binding site [chemical binding]; other site 1093787013673 active site 1093787013674 pyrophosphate binding site [ion binding]; other site 1093787013675 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1093787013676 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1093787013677 putative C-terminal domain interface [polypeptide binding]; other site 1093787013678 putative GSH binding site (G-site) [chemical binding]; other site 1093787013679 putative dimer interface [polypeptide binding]; other site 1093787013680 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 1093787013681 putative N-terminal domain interface [polypeptide binding]; other site 1093787013682 putative dimer interface [polypeptide binding]; other site 1093787013683 putative substrate binding pocket (H-site) [chemical binding]; other site 1093787013684 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1093787013685 heterotetramer interface [polypeptide binding]; other site 1093787013686 active site pocket [active] 1093787013687 cleavage site 1093787013688 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103 1093787013689 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1093787013690 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1093787013691 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1093787013692 nucleotide binding region [chemical binding]; other site 1093787013693 ATP-binding site [chemical binding]; other site 1093787013694 SEC-C motif; Region: SEC-C; pfam02810 1093787013695 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1093787013696 Peptidase family M23; Region: Peptidase_M23; pfam01551 1093787013697 Protein of unknown function (DUF721); Region: DUF721; cl02324 1093787013698 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1093787013699 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1093787013700 cell division protein FtsZ; Validated; Region: PRK09330 1093787013701 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1093787013702 nucleotide binding site [chemical binding]; other site 1093787013703 SulA interaction site; other site 1093787013704 cell division protein FtsA; Region: ftsA; TIGR01174 1093787013705 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1093787013706 nucleotide binding site [chemical binding]; other site 1093787013707 Cell division protein FtsA; Region: FtsA; pfam14450 1093787013708 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1093787013709 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1093787013710 Cell division protein FtsQ; Region: FtsQ; pfam03799 1093787013711 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1093787013712 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1093787013713 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1093787013714 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1093787013715 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1093787013716 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1093787013717 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1093787013718 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1093787013719 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1093787013720 active site 1093787013721 homodimer interface [polypeptide binding]; other site 1093787013722 cell division protein FtsW; Region: ftsW; TIGR02614 1093787013723 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 1093787013724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787013725 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1093787013726 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1093787013727 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1093787013728 Mg++ binding site [ion binding]; other site 1093787013729 putative catalytic motif [active] 1093787013730 putative substrate binding site [chemical binding]; other site 1093787013731 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1093787013732 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1093787013733 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1093787013734 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1093787013735 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1093787013736 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1093787013737 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1093787013738 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1093787013739 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1093787013740 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1093787013741 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1093787013742 Cell division protein [Cell division and chromosome partitioning]; Region: FtsL; COG3116 1093787013743 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1093787013744 MraW methylase family; Region: Methyltransf_5; pfam01795 1093787013745 cell division protein MraZ; Reviewed; Region: PRK00326 1093787013746 MraZ protein; Region: MraZ; pfam02381 1093787013747 MraZ protein; Region: MraZ; pfam02381 1093787013748 Predicted methyltransferases [General function prediction only]; Region: COG0313 1093787013749 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1093787013750 putative SAM binding site [chemical binding]; other site 1093787013751 putative homodimer interface [polypeptide binding]; other site 1093787013752 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 1093787013753 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1093787013754 putative ligand binding site [chemical binding]; other site 1093787013755 hypothetical protein; Reviewed; Region: PRK12497 1093787013756 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1093787013757 dimer interface [polypeptide binding]; other site 1093787013758 active site 1093787013759 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1093787013760 BON domain; Region: BON; pfam04972 1093787013761 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1093787013762 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1093787013763 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1093787013764 C-terminal domain interface [polypeptide binding]; other site 1093787013765 putative GSH binding site (G-site) [chemical binding]; other site 1093787013766 dimer interface [polypeptide binding]; other site 1093787013767 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1093787013768 dimer interface [polypeptide binding]; other site 1093787013769 N-terminal domain interface [polypeptide binding]; other site 1093787013770 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 1093787013771 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1093787013772 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1093787013773 Qi binding site; other site 1093787013774 intrachain domain interface; other site 1093787013775 interchain domain interface [polypeptide binding]; other site 1093787013776 heme bH binding site [chemical binding]; other site 1093787013777 heme bL binding site [chemical binding]; other site 1093787013778 Qo binding site; other site 1093787013779 interchain domain interface [polypeptide binding]; other site 1093787013780 intrachain domain interface; other site 1093787013781 Qi binding site; other site 1093787013782 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 1093787013783 Qo binding site; other site 1093787013784 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1093787013785 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1093787013786 [2Fe-2S] cluster binding site [ion binding]; other site 1093787013787 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1093787013788 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1093787013789 23S rRNA interface [nucleotide binding]; other site 1093787013790 L3 interface [polypeptide binding]; other site 1093787013791 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1093787013792 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1093787013793 active site 1093787013794 catalytic tetrad [active] 1093787013795 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1093787013796 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787013797 active site 1093787013798 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1093787013799 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1093787013800 conserved cys residue [active] 1093787013801 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787013802 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787013803 Predicted ATPase [General function prediction only]; Region: COG1485 1093787013804 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 1093787013805 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1093787013806 active site 1093787013807 HIGH motif; other site 1093787013808 dimer interface [polypeptide binding]; other site 1093787013809 KMSKS motif; other site 1093787013810 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1093787013811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1093787013812 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 1093787013813 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1093787013814 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1093787013815 CysD dimerization site [polypeptide binding]; other site 1093787013816 G1 box; other site 1093787013817 putative GEF interaction site [polypeptide binding]; other site 1093787013818 GTP/Mg2+ binding site [chemical binding]; other site 1093787013819 Switch I region; other site 1093787013820 G2 box; other site 1093787013821 G3 box; other site 1093787013822 Switch II region; other site 1093787013823 G4 box; other site 1093787013824 G5 box; other site 1093787013825 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1093787013826 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1093787013827 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1093787013828 ligand-binding site [chemical binding]; other site 1093787013829 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1093787013830 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1093787013831 Active Sites [active] 1093787013832 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1093787013833 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1093787013834 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1093787013835 catalytic residue [active] 1093787013836 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1093787013837 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1093787013838 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1093787013839 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1093787013840 protein binding site [polypeptide binding]; other site 1093787013841 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1093787013842 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1093787013843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787013844 homodimer interface [polypeptide binding]; other site 1093787013845 catalytic residue [active] 1093787013846 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1093787013847 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1093787013848 NAD binding site [chemical binding]; other site 1093787013849 dimerization interface [polypeptide binding]; other site 1093787013850 product binding site; other site 1093787013851 substrate binding site [chemical binding]; other site 1093787013852 zinc binding site [ion binding]; other site 1093787013853 catalytic residues [active] 1093787013854 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1093787013855 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1093787013856 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1093787013857 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1093787013858 hinge; other site 1093787013859 active site 1093787013860 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1093787013861 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1093787013862 anti sigma factor interaction site; other site 1093787013863 regulatory phosphorylation site [posttranslational modification]; other site 1093787013864 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; COG2854 1093787013865 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1093787013866 mce related protein; Region: MCE; pfam02470 1093787013867 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1093787013868 conserved hypothetical integral membrane protein; Region: TIGR00056 1093787013869 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1093787013870 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1093787013871 Walker A/P-loop; other site 1093787013872 ATP binding site [chemical binding]; other site 1093787013873 Q-loop/lid; other site 1093787013874 ABC transporter signature motif; other site 1093787013875 Walker B; other site 1093787013876 D-loop; other site 1093787013877 H-loop/switch region; other site 1093787013878 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1093787013879 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1093787013880 putative active site [active] 1093787013881 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1093787013882 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 1093787013883 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1093787013884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 1093787013885 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1093787013886 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1093787013887 OstA-like protein; Region: OstA; pfam03968 1093787013888 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1093787013889 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1093787013890 Walker A/P-loop; other site 1093787013891 ATP binding site [chemical binding]; other site 1093787013892 Q-loop/lid; other site 1093787013893 ABC transporter signature motif; other site 1093787013894 Walker B; other site 1093787013895 D-loop; other site 1093787013896 H-loop/switch region; other site 1093787013897 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1093787013898 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1093787013899 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1093787013900 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1093787013901 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1093787013902 30S subunit binding site; other site 1093787013903 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1093787013904 active site 1093787013905 phosphorylation site [posttranslational modification] 1093787013906 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1093787013907 AAA domain; Region: AAA_18; pfam13238 1093787013908 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1093787013909 dimerization domain swap beta strand [polypeptide binding]; other site 1093787013910 regulatory protein interface [polypeptide binding]; other site 1093787013911 active site 1093787013912 regulatory phosphorylation site [posttranslational modification]; other site 1093787013913 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1093787013914 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1093787013915 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1093787013916 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1093787013917 Protein of unknown function (DUF2753); Region: DUF2753; pfam10952 1093787013918 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1093787013919 Class II fumarases; Region: Fumarase_classII; cd01362 1093787013920 active site 1093787013921 tetramer interface [polypeptide binding]; other site 1093787013922 peptidase PmbA; Provisional; Region: PRK11040 1093787013923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3028 1093787013924 protease TldD; Provisional; Region: tldD; PRK10735 1093787013925 nitrilase; Region: PLN02798 1093787013926 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1093787013927 putative active site [active] 1093787013928 catalytic triad [active] 1093787013929 dimer interface [polypeptide binding]; other site 1093787013930 Predicted membrane protein [Function unknown]; Region: COG3164 1093787013931 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1093787013932 ribonuclease G; Provisional; Region: PRK11712 1093787013933 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1093787013934 homodimer interface [polypeptide binding]; other site 1093787013935 oligonucleotide binding site [chemical binding]; other site 1093787013936 Maf-like protein; Region: Maf; pfam02545 1093787013937 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1093787013938 active site 1093787013939 dimer interface [polypeptide binding]; other site 1093787013940 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1093787013941 rod shape-determining protein MreC; Provisional; Region: PRK13922 1093787013942 rod shape-determining protein MreC; Region: MreC; pfam04085 1093787013943 rod shape-determining protein MreB; Provisional; Region: PRK13927 1093787013944 MreB and similar proteins; Region: MreB_like; cd10225 1093787013945 nucleotide binding site [chemical binding]; other site 1093787013946 Mg binding site [ion binding]; other site 1093787013947 putative protofilament interaction site [polypeptide binding]; other site 1093787013948 RodZ interaction site [polypeptide binding]; other site 1093787013949 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1093787013950 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1093787013951 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1093787013952 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1093787013953 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1093787013954 GatB domain; Region: GatB_Yqey; smart00845 1093787013955 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1093787013956 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1093787013957 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1093787013958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1093787013959 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cl17565 1093787013960 putative metal binding site [ion binding]; other site 1093787013961 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 1093787013962 Predicted secreted protein [Function unknown]; Region: COG5445 1093787013963 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 1093787013964 Predicted secreted protein [Function unknown]; Region: COG5445 1093787013965 Stage II sporulation protein; Region: SpoIID; pfam08486 1093787013966 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 1093787013967 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1093787013968 MG2 domain; Region: A2M_N; pfam01835 1093787013969 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1093787013970 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1093787013971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 1093787013972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 1093787013973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1093787013974 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 1093787013975 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1093787013976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787013977 active site 1093787013978 phosphorylation site [posttranslational modification] 1093787013979 intermolecular recognition site; other site 1093787013980 dimerization interface [polypeptide binding]; other site 1093787013981 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1093787013982 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1093787013983 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787013984 phosphorylation site [posttranslational modification] 1093787013985 dimer interface [polypeptide binding]; other site 1093787013986 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 1093787013987 ATP binding site [chemical binding]; other site 1093787013988 G-X-G motif; other site 1093787013989 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3471 1093787013990 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1093787013991 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1093787013992 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1093787013993 peptide binding site [polypeptide binding]; other site 1093787013994 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1093787013995 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1093787013996 peptide binding site [polypeptide binding]; other site 1093787013997 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1093787013998 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1093787013999 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1093787014000 active site 1093787014001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1093787014002 non-specific DNA binding site [nucleotide binding]; other site 1093787014003 salt bridge; other site 1093787014004 sequence-specific DNA binding site [nucleotide binding]; other site 1093787014005 Cupin domain; Region: Cupin_2; pfam07883 1093787014006 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1093787014007 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1093787014008 peptide binding site [polypeptide binding]; other site 1093787014009 outer membrane porin, OprD family; Region: OprD; pfam03573 1093787014010 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1093787014011 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1093787014012 peptide binding site [polypeptide binding]; other site 1093787014013 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1093787014014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787014015 dimer interface [polypeptide binding]; other site 1093787014016 conserved gate region; other site 1093787014017 putative PBP binding loops; other site 1093787014018 ABC-ATPase subunit interface; other site 1093787014019 dipeptide transporter; Provisional; Region: PRK10913 1093787014020 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1093787014021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787014022 putative PBP binding loops; other site 1093787014023 dimer interface [polypeptide binding]; other site 1093787014024 ABC-ATPase subunit interface; other site 1093787014025 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1093787014026 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1093787014027 Walker A/P-loop; other site 1093787014028 ATP binding site [chemical binding]; other site 1093787014029 Q-loop/lid; other site 1093787014030 ABC transporter signature motif; other site 1093787014031 Walker B; other site 1093787014032 D-loop; other site 1093787014033 H-loop/switch region; other site 1093787014034 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1093787014035 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1093787014036 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1093787014037 Walker A/P-loop; other site 1093787014038 ATP binding site [chemical binding]; other site 1093787014039 Q-loop/lid; other site 1093787014040 ABC transporter signature motif; other site 1093787014041 Walker B; other site 1093787014042 D-loop; other site 1093787014043 H-loop/switch region; other site 1093787014044 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1093787014045 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1093787014046 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1093787014047 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1093787014048 putative DNA binding site [nucleotide binding]; other site 1093787014049 putative Zn2+ binding site [ion binding]; other site 1093787014050 AsnC family; Region: AsnC_trans_reg; pfam01037 1093787014051 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1093787014052 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1093787014053 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1093787014054 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1093787014055 putative active site [active] 1093787014056 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1093787014057 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1093787014058 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1093787014059 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1093787014060 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1093787014061 Flavodoxin; Region: Flavodoxin_1; pfam00258 1093787014062 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 1093787014063 FAD binding pocket [chemical binding]; other site 1093787014064 FAD binding motif [chemical binding]; other site 1093787014065 catalytic residues [active] 1093787014066 NAD binding pocket [chemical binding]; other site 1093787014067 phosphate binding motif [ion binding]; other site 1093787014068 beta-alpha-beta structure motif; other site 1093787014069 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1093787014070 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787014071 N-terminal plug; other site 1093787014072 ligand-binding site [chemical binding]; other site 1093787014073 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1093787014074 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1093787014075 Sel1-like repeats; Region: SEL1; smart00671 1093787014076 Sel1-like repeats; Region: SEL1; smart00671 1093787014077 hypothetical protein; Provisional; Region: PRK10649 1093787014078 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1093787014079 Sulfatase; Region: Sulfatase; pfam00884 1093787014080 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1093787014081 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1093787014082 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1093787014083 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1093787014084 dimer interface [polypeptide binding]; other site 1093787014085 active site 1093787014086 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1093787014087 catalytic residues [active] 1093787014088 substrate binding site [chemical binding]; other site 1093787014089 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1093787014090 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787014091 dimerization interface [polypeptide binding]; other site 1093787014092 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787014093 dimer interface [polypeptide binding]; other site 1093787014094 putative CheW interface [polypeptide binding]; other site 1093787014095 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896 1093787014096 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1093787014097 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1093787014098 amidase catalytic site [active] 1093787014099 Zn binding residues [ion binding]; other site 1093787014100 substrate binding site [chemical binding]; other site 1093787014101 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 1093787014102 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742 1093787014103 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1093787014104 dimerization interface [polypeptide binding]; other site 1093787014105 active site 1093787014106 Pilin (bacterial filament); Region: Pilin; pfam00114 1093787014107 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1093787014108 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1093787014109 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1093787014110 Walker A motif; other site 1093787014111 ATP binding site [chemical binding]; other site 1093787014112 Walker B motif; other site 1093787014113 HTH-like domain; Region: HTH_21; pfam13276 1093787014114 Integrase core domain; Region: rve; pfam00665 1093787014115 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1093787014116 Integrase core domain; Region: rve_3; pfam13683 1093787014117 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1093787014118 Transposase; Region: HTH_Tnp_1; pfam01527 1093787014119 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1093787014120 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1093787014121 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1093787014122 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1093787014123 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1093787014124 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1093787014125 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1093787014126 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1093787014127 CoA-binding site [chemical binding]; other site 1093787014128 ATP-binding [chemical binding]; other site 1093787014129 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1093787014130 Predicted membrane protein [Function unknown]; Region: COG3235 1093787014131 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1093787014132 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1093787014133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787014134 Coenzyme A binding pocket [chemical binding]; other site 1093787014135 Protein of unknown function (DUF1780); Region: DUF1780; pfam08682 1093787014136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1093787014137 MOSC domain; Region: MOSC; pfam03473 1093787014138 Protein of unknown function (DUF3094); Region: DUF3094; pfam11293 1093787014139 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1093787014140 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1093787014141 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1093787014142 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1093787014143 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1093787014144 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1093787014145 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1093787014146 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1093787014147 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1093787014148 P-loop; other site 1093787014149 Magnesium ion binding site [ion binding]; other site 1093787014150 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1093787014151 Magnesium ion binding site [ion binding]; other site 1093787014152 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1093787014153 replicative DNA helicase; Region: DnaB; TIGR00665 1093787014154 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1093787014155 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1093787014156 Walker A motif; other site 1093787014157 ATP binding site [chemical binding]; other site 1093787014158 Walker B motif; other site 1093787014159 DNA binding loops [nucleotide binding] 1093787014160 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1093787014161 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1093787014162 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1093787014163 Arc-like DNA binding domain; Region: Arc; pfam03869 1093787014164 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 1093787014165 ParB-like nuclease domain; Region: ParB; smart00470 1093787014166 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 1093787014167 integrating conjugative element protein, PFL_4669 family; Region: ICE_PFL4669; TIGR03761 1093787014168 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 1093787014169 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1093787014170 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1093787014171 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1093787014172 dimer interface [polypeptide binding]; other site 1093787014173 ssDNA binding site [nucleotide binding]; other site 1093787014174 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1093787014175 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 1093787014176 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1093787014177 active site 1093787014178 metal binding site [ion binding]; metal-binding site 1093787014179 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1093787014180 domain I; other site 1093787014181 DNA binding groove [nucleotide binding] 1093787014182 phosphate binding site [ion binding]; other site 1093787014183 domain II; other site 1093787014184 domain III; other site 1093787014185 nucleotide binding site [chemical binding]; other site 1093787014186 catalytic site [active] 1093787014187 domain IV; other site 1093787014188 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1093787014189 ATP binding site [chemical binding]; other site 1093787014190 putative Mg++ binding site [ion binding]; other site 1093787014191 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1093787014192 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1093787014193 nucleotide binding region [chemical binding]; other site 1093787014194 ATP-binding site [chemical binding]; other site 1093787014195 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 1093787014196 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 1093787014197 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 1093787014198 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 1093787014199 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1093787014200 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 1093787014201 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 1093787014202 Type II/IV secretion system protein; Region: T2SE; pfam00437 1093787014203 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1093787014204 Walker A motif; other site 1093787014205 ATP binding site [chemical binding]; other site 1093787014206 Walker B motif; other site 1093787014207 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1093787014208 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1093787014209 PilS N terminal; Region: PilS; pfam08805 1093787014210 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1093787014211 Walker A motif; other site 1093787014212 ATP binding site [chemical binding]; other site 1093787014213 Walker B motif; other site 1093787014214 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 1093787014215 PilM; Region: PilM; pfam07419 1093787014216 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 1093787014217 Protein of unknown function (DUF3275); Region: DUF3275; pfam11679 1093787014218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787014219 S-adenosylmethionine binding site [chemical binding]; other site 1093787014220 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1093787014221 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 1093787014222 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1093787014223 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1093787014224 putative active site [active] 1093787014225 putative NTP binding site [chemical binding]; other site 1093787014226 putative nucleic acid binding site [nucleotide binding]; other site 1093787014227 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1093787014228 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1093787014229 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1093787014230 active site 1093787014231 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1093787014232 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1093787014233 putative Mg++ binding site [ion binding]; other site 1093787014234 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1093787014235 nucleotide binding region [chemical binding]; other site 1093787014236 ATP-binding site [chemical binding]; other site 1093787014237 Integrase core domain; Region: rve; pfam00665 1093787014238 Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505 1093787014239 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 1093787014240 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 1093787014241 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 1093787014242 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 1093787014243 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 1093787014244 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1093787014245 Family description; Region: UvrD_C_2; pfam13538 1093787014246 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 1093787014247 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1093787014248 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 1093787014249 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 1093787014250 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 1093787014251 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 1093787014252 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 1093787014253 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 1093787014254 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 1093787014255 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1093787014256 Protein of unknown function (DUF972); Region: DUF972; pfam06156 1093787014257 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 1093787014258 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 1093787014259 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 1093787014260 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1093787014261 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1093787014262 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1093787014263 Thioredoxin; Region: Thioredoxin_4; cl17273 1093787014264 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 1093787014265 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 1093787014266 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 1093787014267 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 1093787014268 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 1093787014269 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1093787014270 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 1093787014271 DNA methylase; Region: N6_N4_Mtase; cl17433 1093787014272 Putative helicase; Region: TraI_2; pfam07514 1093787014273 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1093787014274 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 1093787014275 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1093787014276 active site 1093787014277 catalytic residues [active] 1093787014278 DNA binding site [nucleotide binding] 1093787014279 Int/Topo IB signature motif; other site 1093787014280 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1093787014281 Clp amino terminal domain; Region: Clp_N; pfam02861 1093787014282 Clp amino terminal domain; Region: Clp_N; pfam02861 1093787014283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787014284 Walker A motif; other site 1093787014285 ATP binding site [chemical binding]; other site 1093787014286 Walker B motif; other site 1093787014287 arginine finger; other site 1093787014288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787014289 Walker A motif; other site 1093787014290 ATP binding site [chemical binding]; other site 1093787014291 Walker B motif; other site 1093787014292 arginine finger; other site 1093787014293 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1093787014294 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1093787014295 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1093787014296 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1093787014297 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1093787014298 RNA binding surface [nucleotide binding]; other site 1093787014299 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1093787014300 active site 1093787014301 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1093787014302 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1093787014303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787014304 dimer interface [polypeptide binding]; other site 1093787014305 phosphorylation site [posttranslational modification] 1093787014306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787014307 ATP binding site [chemical binding]; other site 1093787014308 Mg2+ binding site [ion binding]; other site 1093787014309 G-X-G motif; other site 1093787014310 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1093787014311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787014312 active site 1093787014313 phosphorylation site [posttranslational modification] 1093787014314 intermolecular recognition site; other site 1093787014315 dimerization interface [polypeptide binding]; other site 1093787014316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787014317 Walker A motif; other site 1093787014318 ATP binding site [chemical binding]; other site 1093787014319 Walker B motif; other site 1093787014320 arginine finger; other site 1093787014321 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1093787014322 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1093787014323 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1093787014324 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 1093787014325 Type II transport protein GspH; Region: GspH; pfam12019 1093787014326 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 1093787014327 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1093787014328 Type II transport protein GspH; Region: GspH; pfam12019 1093787014329 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 1093787014330 Prokaryotic N-terminal methylation site; Region: N_methyl_3; pfam13633 1093787014331 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 1093787014332 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 1093787014333 PilX N-terminal; Region: PilX_N; pfam14341 1093787014334 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 1093787014335 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 1093787014336 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1093787014337 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1093787014338 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1093787014339 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1093787014340 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1093787014341 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1093787014342 lipoprotein signal peptidase; Provisional; Region: PRK14787 1093787014343 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1093787014344 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1093787014345 active site 1093787014346 HIGH motif; other site 1093787014347 nucleotide binding site [chemical binding]; other site 1093787014348 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1093787014349 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1093787014350 active site 1093787014351 KMSKS motif; other site 1093787014352 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1093787014353 tRNA binding surface [nucleotide binding]; other site 1093787014354 anticodon binding site; other site 1093787014355 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1093787014356 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1093787014357 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1093787014358 active site 1093787014359 Riboflavin kinase; Region: Flavokinase; pfam01687 1093787014360 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1093787014361 MviN-like protein; Region: MVIN; pfam03023 1093787014362 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1093787014363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 1093787014364 CreA protein; Region: CreA; pfam05981 1093787014365 gamma-glutamyl kinase; Provisional; Region: PRK05429 1093787014366 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1093787014367 nucleotide binding site [chemical binding]; other site 1093787014368 homotetrameric interface [polypeptide binding]; other site 1093787014369 putative phosphate binding site [ion binding]; other site 1093787014370 putative allosteric binding site; other site 1093787014371 PUA domain; Region: PUA; pfam01472 1093787014372 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1093787014373 GTP1/OBG; Region: GTP1_OBG; pfam01018 1093787014374 Obg GTPase; Region: Obg; cd01898 1093787014375 G1 box; other site 1093787014376 GTP/Mg2+ binding site [chemical binding]; other site 1093787014377 Switch I region; other site 1093787014378 G2 box; other site 1093787014379 G3 box; other site 1093787014380 Switch II region; other site 1093787014381 G4 box; other site 1093787014382 G5 box; other site 1093787014383 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1093787014384 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1093787014385 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1093787014386 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1093787014387 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1093787014388 substrate binding pocket [chemical binding]; other site 1093787014389 chain length determination region; other site 1093787014390 substrate-Mg2+ binding site; other site 1093787014391 catalytic residues [active] 1093787014392 aspartate-rich region 1; other site 1093787014393 active site lid residues [active] 1093787014394 aspartate-rich region 2; other site 1093787014395 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1093787014396 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1093787014397 Cytochrome c; Region: Cytochrom_C; pfam00034 1093787014398 Cytochrome c [Energy production and conversion]; Region: COG3258 1093787014399 Cytochrome c; Region: Cytochrom_C; pfam00034 1093787014400 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1093787014401 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1093787014402 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1093787014403 hypothetical protein; Provisional; Region: PRK05208 1093787014404 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 1093787014405 AAA domain; Region: AAA_32; pfam13654 1093787014406 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1093787014407 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1093787014408 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 1093787014409 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1093787014410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 1093787014411 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 1093787014412 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 1093787014413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787014414 Walker A motif; other site 1093787014415 ATP binding site [chemical binding]; other site 1093787014416 Walker B motif; other site 1093787014417 arginine finger; other site 1093787014418 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1093787014419 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1093787014420 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1093787014421 hypothetical protein; Reviewed; Region: PRK09588 1093787014422 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1093787014423 active site 1093787014424 NTP binding site [chemical binding]; other site 1093787014425 metal binding triad [ion binding]; metal-binding site 1093787014426 antibiotic binding site [chemical binding]; other site 1093787014427 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 1093787014428 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 1093787014429 putative active site [active] 1093787014430 adenylation catalytic residue [active] 1093787014431 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1093787014432 glutamate dehydrogenase; Provisional; Region: PRK09414 1093787014433 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1093787014434 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1093787014435 NAD(P) binding site [chemical binding]; other site 1093787014436 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 1093787014437 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1093787014438 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787014439 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787014440 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1093787014441 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1093787014442 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1093787014443 FtsX-like permease family; Region: FtsX; pfam02687 1093787014444 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1093787014445 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1093787014446 Walker A/P-loop; other site 1093787014447 ATP binding site [chemical binding]; other site 1093787014448 Q-loop/lid; other site 1093787014449 ABC transporter signature motif; other site 1093787014450 Walker B; other site 1093787014451 D-loop; other site 1093787014452 H-loop/switch region; other site 1093787014453 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1093787014454 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1093787014455 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1093787014456 ABC transporter; Region: ABC_tran_2; pfam12848 1093787014457 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1093787014458 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787014459 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787014460 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1093787014461 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1093787014462 Protein export membrane protein; Region: SecD_SecF; cl14618 1093787014463 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 1093787014464 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787014465 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787014466 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787014467 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 1093787014468 PAS domain; Region: PAS_9; pfam13426 1093787014469 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787014470 PAS fold; Region: PAS_3; pfam08447 1093787014471 putative active site [active] 1093787014472 heme pocket [chemical binding]; other site 1093787014473 PAS domain; Region: PAS_9; pfam13426 1093787014474 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1093787014475 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787014476 PAS domain; Region: PAS_9; pfam13426 1093787014477 putative active site [active] 1093787014478 heme pocket [chemical binding]; other site 1093787014479 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787014480 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787014481 metal binding site [ion binding]; metal-binding site 1093787014482 active site 1093787014483 I-site; other site 1093787014484 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1093787014485 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1093787014486 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1093787014487 dimer interface [polypeptide binding]; other site 1093787014488 active site 1093787014489 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1093787014490 folate binding site [chemical binding]; other site 1093787014491 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1093787014492 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1093787014493 P-loop, Walker A motif; other site 1093787014494 Base recognition motif; other site 1093787014495 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1093787014496 Uncharacterized small protein [Function unknown]; Region: COG2879 1093787014497 carbon starvation protein A; Provisional; Region: PRK15015 1093787014498 Carbon starvation protein CstA; Region: CstA; pfam02554 1093787014499 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1093787014500 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 1093787014501 PilZ domain; Region: PilZ; pfam07238 1093787014502 DNA repair protein RadA; Provisional; Region: PRK11823 1093787014503 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1093787014504 Walker A motif/ATP binding site; other site 1093787014505 ATP binding site [chemical binding]; other site 1093787014506 Walker B motif; other site 1093787014507 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1093787014508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 1093787014509 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1093787014510 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1093787014511 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1093787014512 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1093787014513 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1093787014514 tetramer interface [polypeptide binding]; other site 1093787014515 heme binding pocket [chemical binding]; other site 1093787014516 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1093787014517 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1093787014518 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1093787014519 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1093787014520 FAD binding pocket [chemical binding]; other site 1093787014521 FAD binding motif [chemical binding]; other site 1093787014522 phosphate binding motif [ion binding]; other site 1093787014523 beta-alpha-beta structure motif; other site 1093787014524 NAD binding pocket [chemical binding]; other site 1093787014525 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1093787014526 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1093787014527 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1093787014528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787014529 S-adenosylmethionine binding site [chemical binding]; other site 1093787014530 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1093787014531 Ligand binding site; other site 1093787014532 metal-binding site 1093787014533 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1093787014534 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1093787014535 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1093787014536 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1093787014537 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1093787014538 Cytochrome c; Region: Cytochrom_C; pfam00034 1093787014539 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1093787014540 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1093787014541 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1093787014542 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1093787014543 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1093787014544 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1093787014545 H+ Antiporter protein; Region: 2A0121; TIGR00900 1093787014546 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1093787014547 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1093787014548 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1093787014549 glycerate dehydrogenase; Provisional; Region: PRK06487 1093787014550 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1093787014551 putative ligand binding site [chemical binding]; other site 1093787014552 putative NAD binding site [chemical binding]; other site 1093787014553 catalytic site [active] 1093787014554 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1093787014555 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1093787014556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787014557 S-adenosylmethionine binding site [chemical binding]; other site 1093787014558 lysine transporter; Provisional; Region: PRK10836 1093787014559 Predicted membrane protein [Function unknown]; Region: COG2119 1093787014560 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1093787014561 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1093787014562 conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096 1093787014563 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1093787014564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787014565 NAD(P) binding site [chemical binding]; other site 1093787014566 active site 1093787014567 Peptidase family M48; Region: Peptidase_M48; pfam01435 1093787014568 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787014569 dimerization interface [polypeptide binding]; other site 1093787014570 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1093787014571 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787014572 dimer interface [polypeptide binding]; other site 1093787014573 putative CheW interface [polypeptide binding]; other site 1093787014574 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1093787014575 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1093787014576 MgtC family; Region: MgtC; pfam02308 1093787014577 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1093787014578 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 1093787014579 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1093787014580 putative acyl-acceptor binding pocket; other site 1093787014581 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 1093787014582 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1093787014583 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1093787014584 dimer interface [polypeptide binding]; other site 1093787014585 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1093787014586 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 1093787014587 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1093787014588 active site 1093787014589 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1093787014590 active site 1093787014591 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1093787014592 Uncharacterized secreted protein [Function unknown]; Region: COG5430 1093787014593 Uncharacterized secreted protein [Function unknown]; Region: COG5430 1093787014594 Uncharacterized secreted protein [Function unknown]; Region: COG5430 1093787014595 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1093787014596 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1093787014597 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1093787014598 PapC N-terminal domain; Region: PapC_N; pfam13954 1093787014599 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1093787014600 PapC C-terminal domain; Region: PapC_C; pfam13953 1093787014601 Spore Coat Protein U domain; Region: SCPU; pfam05229 1093787014602 Uncharacterized secreted protein [Function unknown]; Region: COG5430 1093787014603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787014604 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1093787014605 putative substrate translocation pore; other site 1093787014606 ferrochelatase; Reviewed; Region: hemH; PRK00035 1093787014607 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1093787014608 C-terminal domain interface [polypeptide binding]; other site 1093787014609 active site 1093787014610 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1093787014611 active site 1093787014612 N-terminal domain interface [polypeptide binding]; other site 1093787014613 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1093787014614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787014615 NAD(P) binding site [chemical binding]; other site 1093787014616 active site 1093787014617 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1093787014618 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1093787014619 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1093787014620 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1093787014621 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1093787014622 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1093787014623 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1093787014624 DNA binding residues [nucleotide binding] 1093787014625 B12 binding domain; Region: B12-binding_2; pfam02607 1093787014626 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1093787014627 DNA photolyase; Region: DNA_photolyase; pfam00875 1093787014628 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1093787014629 glutamate racemase; Provisional; Region: PRK00865 1093787014630 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1093787014631 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1093787014632 ATP binding site [chemical binding]; other site 1093787014633 substrate interface [chemical binding]; other site 1093787014634 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1093787014635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787014636 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1093787014637 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1093787014638 RF-1 domain; Region: RF-1; pfam00472 1093787014639 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1093787014640 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1093787014641 tRNA; other site 1093787014642 putative tRNA binding site [nucleotide binding]; other site 1093787014643 putative NADP binding site [chemical binding]; other site 1093787014644 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1093787014645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1093787014646 TPR motif; other site 1093787014647 binding surface 1093787014648 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1093787014649 binding surface 1093787014650 TPR motif; other site 1093787014651 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1093787014652 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1093787014653 binding surface 1093787014654 TPR motif; other site 1093787014655 TPR repeat; Region: TPR_11; pfam13414 1093787014656 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1093787014657 binding surface 1093787014658 TPR motif; other site 1093787014659 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1093787014660 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1093787014661 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1093787014662 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1093787014663 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1093787014664 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1093787014665 active site 1093787014666 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1093787014667 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1093787014668 5S rRNA interface [nucleotide binding]; other site 1093787014669 CTC domain interface [polypeptide binding]; other site 1093787014670 L16 interface [polypeptide binding]; other site 1093787014671 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1093787014672 metal binding site [ion binding]; metal-binding site 1093787014673 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1093787014674 putative active site [active] 1093787014675 catalytic residue [active] 1093787014676 GTP-binding protein YchF; Reviewed; Region: PRK09601 1093787014677 YchF GTPase; Region: YchF; cd01900 1093787014678 G1 box; other site 1093787014679 GTP/Mg2+ binding site [chemical binding]; other site 1093787014680 Switch I region; other site 1093787014681 G2 box; other site 1093787014682 Switch II region; other site 1093787014683 G3 box; other site 1093787014684 G4 box; other site 1093787014685 G5 box; other site 1093787014686 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1093787014687 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1093787014688 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1093787014689 non-specific DNA binding site [nucleotide binding]; other site 1093787014690 salt bridge; other site 1093787014691 sequence-specific DNA binding site [nucleotide binding]; other site 1093787014692 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1093787014693 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1093787014694 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787014695 N-terminal plug; other site 1093787014696 ligand-binding site [chemical binding]; other site 1093787014697 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1093787014698 active site clefts [active] 1093787014699 zinc binding site [ion binding]; other site 1093787014700 dimer interface [polypeptide binding]; other site 1093787014701 Peptidase family C69; Region: Peptidase_C69; cl17793 1093787014702 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1093787014703 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1093787014704 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1093787014705 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1093787014706 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1093787014707 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1093787014708 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1093787014709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787014710 dimer interface [polypeptide binding]; other site 1093787014711 conserved gate region; other site 1093787014712 putative PBP binding loops; other site 1093787014713 ABC-ATPase subunit interface; other site 1093787014714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787014715 dimer interface [polypeptide binding]; other site 1093787014716 conserved gate region; other site 1093787014717 putative PBP binding loops; other site 1093787014718 ABC-ATPase subunit interface; other site 1093787014719 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1093787014720 mce related protein; Region: MCE; pfam02470 1093787014721 mce related protein; Region: MCE; pfam02470 1093787014722 mce related protein; Region: MCE; pfam02470 1093787014723 mce related protein; Region: MCE; pfam02470 1093787014724 mce related protein; Region: MCE; pfam02470 1093787014725 mce related protein; Region: MCE; pfam02470 1093787014726 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1093787014727 Paraquat-inducible protein A; Region: PqiA; pfam04403 1093787014728 Paraquat-inducible protein A; Region: PqiA; pfam04403 1093787014729 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1093787014730 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1093787014731 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1093787014732 Moco binding site; other site 1093787014733 metal coordination site [ion binding]; other site 1093787014734 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1093787014735 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1093787014736 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1093787014737 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1093787014738 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1093787014739 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1093787014740 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1093787014741 putative valine binding site [chemical binding]; other site 1093787014742 dimer interface [polypeptide binding]; other site 1093787014743 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1093787014744 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 1093787014745 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1093787014746 PYR/PP interface [polypeptide binding]; other site 1093787014747 dimer interface [polypeptide binding]; other site 1093787014748 TPP binding site [chemical binding]; other site 1093787014749 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1093787014750 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1093787014751 TPP-binding site [chemical binding]; other site 1093787014752 dimer interface [polypeptide binding]; other site 1093787014753 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1093787014754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 1093787014755 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1093787014756 TPR motif; other site 1093787014757 binding surface 1093787014758 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 1093787014759 Transglycosylase; Region: Transgly; pfam00912 1093787014760 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1093787014761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1093787014762 Predicted kinase [General function prediction only]; Region: COG0645 1093787014763 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1093787014764 ATP-binding site [chemical binding]; other site 1093787014765 Gluconate-6-phosphate binding site [chemical binding]; other site 1093787014766 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1093787014767 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1093787014768 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1093787014769 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1093787014770 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1093787014771 ligand binding site [chemical binding]; other site 1093787014772 flexible hinge region; other site 1093787014773 Uncharacterized iron-regulated protein [Function unknown]; Region: PhuW; COG3016 1093787014774 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1093787014775 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1093787014776 Walker A/P-loop; other site 1093787014777 ATP binding site [chemical binding]; other site 1093787014778 Q-loop/lid; other site 1093787014779 ABC transporter signature motif; other site 1093787014780 Walker B; other site 1093787014781 D-loop; other site 1093787014782 H-loop/switch region; other site 1093787014783 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1093787014784 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1093787014785 ABC-ATPase subunit interface; other site 1093787014786 dimer interface [polypeptide binding]; other site 1093787014787 putative PBP binding regions; other site 1093787014788 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1093787014789 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 1093787014790 putative hemin binding site; other site 1093787014791 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 1093787014792 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1093787014793 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1093787014794 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1093787014795 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787014796 N-terminal plug; other site 1093787014797 ligand-binding site [chemical binding]; other site 1093787014798 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1093787014799 iron-sulfur cluster [ion binding]; other site 1093787014800 [2Fe-2S] cluster binding site [ion binding]; other site 1093787014801 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1093787014802 Predicted metal-binding protein [General function prediction only]; Region: COG3019 1093787014803 aminotransferase; Validated; Region: PRK08175 1093787014804 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1093787014805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787014806 homodimer interface [polypeptide binding]; other site 1093787014807 catalytic residue [active] 1093787014808 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1093787014809 Predicted metalloprotease [General function prediction only]; Region: COG2321 1093787014810 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1093787014811 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1093787014812 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1093787014813 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1093787014814 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1093787014815 hypothetical protein; Provisional; Region: PRK08960 1093787014816 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1093787014817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787014818 homodimer interface [polypeptide binding]; other site 1093787014819 catalytic residue [active] 1093787014820 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1093787014821 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1093787014822 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1093787014823 active site 1093787014824 HIGH motif; other site 1093787014825 nucleotide binding site [chemical binding]; other site 1093787014826 KMSKS motif; other site 1093787014827 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1093787014828 Na binding site [ion binding]; other site 1093787014829 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1093787014830 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1093787014831 putative active site [active] 1093787014832 heme pocket [chemical binding]; other site 1093787014833 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787014834 dimer interface [polypeptide binding]; other site 1093787014835 phosphorylation site [posttranslational modification] 1093787014836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787014837 ATP binding site [chemical binding]; other site 1093787014838 Mg2+ binding site [ion binding]; other site 1093787014839 G-X-G motif; other site 1093787014840 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1093787014841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787014842 active site 1093787014843 phosphorylation site [posttranslational modification] 1093787014844 intermolecular recognition site; other site 1093787014845 dimerization interface [polypeptide binding]; other site 1093787014846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787014847 Walker A motif; other site 1093787014848 ATP binding site [chemical binding]; other site 1093787014849 Walker B motif; other site 1093787014850 arginine finger; other site 1093787014851 poly(A) polymerase; Region: pcnB; TIGR01942 1093787014852 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1093787014853 active site 1093787014854 NTP binding site [chemical binding]; other site 1093787014855 metal binding triad [ion binding]; metal-binding site 1093787014856 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1093787014857 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1093787014858 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1093787014859 catalytic center binding site [active] 1093787014860 ATP binding site [chemical binding]; other site 1093787014861 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1093787014862 oligomerization interface [polypeptide binding]; other site 1093787014863 active site 1093787014864 metal binding site [ion binding]; metal-binding site 1093787014865 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1093787014866 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1093787014867 active site 1093787014868 ATP-binding site [chemical binding]; other site 1093787014869 pantoate-binding site; other site 1093787014870 HXXH motif; other site 1093787014871 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1093787014872 tetramerization interface [polypeptide binding]; other site 1093787014873 active site 1093787014874 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1093787014875 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1093787014876 active site 1093787014877 dimer interface [polypeptide binding]; other site 1093787014878 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1093787014879 dimer interface [polypeptide binding]; other site 1093787014880 active site 1093787014881 acetyl-CoA synthetase; Provisional; Region: PRK00174 1093787014882 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1093787014883 active site 1093787014884 CoA binding site [chemical binding]; other site 1093787014885 acyl-activating enzyme (AAE) consensus motif; other site 1093787014886 AMP binding site [chemical binding]; other site 1093787014887 acetate binding site [chemical binding]; other site 1093787014888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1093787014889 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1093787014890 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1093787014891 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1093787014892 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1093787014893 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1093787014894 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 1093787014895 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 1093787014896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1093787014897 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1093787014898 BON domain; Region: BON; pfam04972 1093787014899 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1093787014900 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1093787014901 RNase E interface [polypeptide binding]; other site 1093787014902 trimer interface [polypeptide binding]; other site 1093787014903 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1093787014904 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1093787014905 RNase E interface [polypeptide binding]; other site 1093787014906 trimer interface [polypeptide binding]; other site 1093787014907 active site 1093787014908 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1093787014909 putative nucleic acid binding region [nucleotide binding]; other site 1093787014910 G-X-X-G motif; other site 1093787014911 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1093787014912 RNA binding site [nucleotide binding]; other site 1093787014913 domain interface; other site 1093787014914 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1093787014915 16S/18S rRNA binding site [nucleotide binding]; other site 1093787014916 S13e-L30e interaction site [polypeptide binding]; other site 1093787014917 25S rRNA binding site [nucleotide binding]; other site 1093787014918 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1093787014919 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1093787014920 RNA binding site [nucleotide binding]; other site 1093787014921 active site 1093787014922 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1093787014923 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1093787014924 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1093787014925 translation initiation factor IF-2; Region: IF-2; TIGR00487 1093787014926 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1093787014927 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1093787014928 G1 box; other site 1093787014929 putative GEF interaction site [polypeptide binding]; other site 1093787014930 GTP/Mg2+ binding site [chemical binding]; other site 1093787014931 Switch I region; other site 1093787014932 G2 box; other site 1093787014933 G3 box; other site 1093787014934 Switch II region; other site 1093787014935 G4 box; other site 1093787014936 G5 box; other site 1093787014937 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1093787014938 Translation-initiation factor 2; Region: IF-2; pfam11987 1093787014939 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1093787014940 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1093787014941 NusA N-terminal domain; Region: NusA_N; pfam08529 1093787014942 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1093787014943 RNA binding site [nucleotide binding]; other site 1093787014944 homodimer interface [polypeptide binding]; other site 1093787014945 NusA-like KH domain; Region: KH_5; pfam13184 1093787014946 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1093787014947 G-X-X-G motif; other site 1093787014948 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1093787014949 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1093787014950 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1093787014951 Sm and related proteins; Region: Sm_like; cl00259 1093787014952 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1093787014953 putative oligomer interface [polypeptide binding]; other site 1093787014954 putative RNA binding site [nucleotide binding]; other site 1093787014955 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1093787014956 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1093787014957 triosephosphate isomerase; Provisional; Region: PRK14567 1093787014958 substrate binding site [chemical binding]; other site 1093787014959 dimer interface [polypeptide binding]; other site 1093787014960 catalytic triad [active] 1093787014961 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1093787014962 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1093787014963 active site 1093787014964 substrate binding site [chemical binding]; other site 1093787014965 metal binding site [ion binding]; metal-binding site 1093787014966 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1093787014967 dihydropteroate synthase; Region: DHPS; TIGR01496 1093787014968 substrate binding pocket [chemical binding]; other site 1093787014969 dimer interface [polypeptide binding]; other site 1093787014970 inhibitor binding site; inhibition site 1093787014971 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1093787014972 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787014973 Walker A motif; other site 1093787014974 ATP binding site [chemical binding]; other site 1093787014975 Walker B motif; other site 1093787014976 arginine finger; other site 1093787014977 Peptidase family M41; Region: Peptidase_M41; pfam01434 1093787014978 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1093787014979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787014980 S-adenosylmethionine binding site [chemical binding]; other site 1093787014981 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1093787014982 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1093787014983 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1093787014984 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1093787014985 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1093787014986 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1093787014987 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1093787014988 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1093787014989 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1093787014990 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1093787014991 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1093787014992 IMP binding site; other site 1093787014993 dimer interface [polypeptide binding]; other site 1093787014994 interdomain contacts; other site 1093787014995 partial ornithine binding site; other site 1093787014996 leucine export protein LeuE; Provisional; Region: PRK10958 1093787014997 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1093787014998 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1093787014999 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1093787015000 catalytic site [active] 1093787015001 subunit interface [polypeptide binding]; other site 1093787015002 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1093787015003 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1093787015004 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1093787015005 chaperone protein DnaJ; Provisional; Region: PRK10767 1093787015006 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1093787015007 HSP70 interaction site [polypeptide binding]; other site 1093787015008 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1093787015009 substrate binding site [polypeptide binding]; other site 1093787015010 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1093787015011 Zn binding sites [ion binding]; other site 1093787015012 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1093787015013 dimer interface [polypeptide binding]; other site 1093787015014 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1093787015015 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1093787015016 nucleotide binding site [chemical binding]; other site 1093787015017 GrpE; Region: GrpE; pfam01025 1093787015018 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1093787015019 dimer interface [polypeptide binding]; other site 1093787015020 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1093787015021 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1093787015022 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1093787015023 Walker A/P-loop; other site 1093787015024 ATP binding site [chemical binding]; other site 1093787015025 Q-loop/lid; other site 1093787015026 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1093787015027 ABC transporter signature motif; other site 1093787015028 Walker B; other site 1093787015029 D-loop; other site 1093787015030 H-loop/switch region; other site 1093787015031 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1093787015032 metal binding site 2 [ion binding]; metal-binding site 1093787015033 putative DNA binding helix; other site 1093787015034 metal binding site 1 [ion binding]; metal-binding site 1093787015035 dimer interface [polypeptide binding]; other site 1093787015036 structural Zn2+ binding site [ion binding]; other site 1093787015037 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1093787015038 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1093787015039 RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658 1093787015040 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1093787015041 putative coenzyme Q binding site [chemical binding]; other site 1093787015042 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1093787015043 SmpB-tmRNA interface; other site 1093787015044 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1093787015045 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787015046 DNA-binding site [nucleotide binding]; DNA binding site 1093787015047 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1093787015048 glycolate transporter; Provisional; Region: PRK09695 1093787015049 L-lactate permease; Region: Lactate_perm; cl00701 1093787015050 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1093787015051 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1093787015052 phosphate binding site [ion binding]; other site 1093787015053 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1093787015054 FAD binding domain; Region: FAD_binding_4; pfam01565 1093787015055 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1093787015056 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1093787015057 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 1093787015058 spermidine synthase; Provisional; Region: PRK00811 1093787015059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787015060 S-adenosylmethionine binding site [chemical binding]; other site 1093787015061 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1093787015062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787015063 active site 1093787015064 phosphorylation site [posttranslational modification] 1093787015065 intermolecular recognition site; other site 1093787015066 dimerization interface [polypeptide binding]; other site 1093787015067 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787015068 DNA binding site [nucleotide binding] 1093787015069 sensor protein QseC; Provisional; Region: PRK10337 1093787015070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787015071 dimer interface [polypeptide binding]; other site 1093787015072 phosphorylation site [posttranslational modification] 1093787015073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787015074 ATP binding site [chemical binding]; other site 1093787015075 Mg2+ binding site [ion binding]; other site 1093787015076 G-X-G motif; other site 1093787015077 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1093787015078 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1093787015079 DNA binding residues [nucleotide binding] 1093787015080 dimer interface [polypeptide binding]; other site 1093787015081 copper binding site [ion binding]; other site 1093787015082 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 1093787015083 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1093787015084 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 1093787015085 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 1093787015086 ATP binding site [chemical binding]; other site 1093787015087 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1093787015088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787015089 active site 1093787015090 phosphorylation site [posttranslational modification] 1093787015091 intermolecular recognition site; other site 1093787015092 dimerization interface [polypeptide binding]; other site 1093787015093 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1093787015094 Zn2+ binding site [ion binding]; other site 1093787015095 Mg2+ binding site [ion binding]; other site 1093787015096 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1093787015097 EamA-like transporter family; Region: EamA; pfam00892 1093787015098 EamA-like transporter family; Region: EamA; pfam00892 1093787015099 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1093787015100 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1093787015101 putative DNA binding site [nucleotide binding]; other site 1093787015102 putative Zn2+ binding site [ion binding]; other site 1093787015103 AsnC family; Region: AsnC_trans_reg; pfam01037 1093787015104 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1093787015105 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1093787015106 dimer interface [polypeptide binding]; other site 1093787015107 active site 1093787015108 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1093787015109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787015110 NAD(P) binding site [chemical binding]; other site 1093787015111 active site 1093787015112 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1093787015113 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1093787015114 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787015115 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1093787015116 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1093787015117 active site 2 [active] 1093787015118 active site 1 [active] 1093787015119 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1093787015120 homodimer interface [polypeptide binding]; other site 1093787015121 chemical substrate binding site [chemical binding]; other site 1093787015122 oligomer interface [polypeptide binding]; other site 1093787015123 metal binding site [ion binding]; metal-binding site 1093787015124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787015125 S-adenosylmethionine binding site [chemical binding]; other site 1093787015126 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1093787015127 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1093787015128 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 1093787015129 putative active site [active] 1093787015130 catalytic site [active] 1093787015131 putative metal binding site [ion binding]; other site 1093787015132 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1093787015133 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1093787015134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787015135 Coenzyme A binding pocket [chemical binding]; other site 1093787015136 Predicted peroxiredoxins [General function prediction only]; Region: COG2044 1093787015137 glycine cleavage system protein H; Provisional; Region: PRK13380 1093787015138 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1093787015139 lipoyl attachment site [posttranslational modification]; other site 1093787015140 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1093787015141 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1093787015142 AAA domain; Region: AAA_17; pfam13207 1093787015143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787015144 S-adenosylmethionine binding site [chemical binding]; other site 1093787015145 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1093787015146 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1093787015147 active site 1093787015148 catalytic triad [active] 1093787015149 dimer interface [polypeptide binding]; other site 1093787015150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787015151 S-adenosylmethionine binding site [chemical binding]; other site 1093787015152 Amino acid permease; Region: AA_permease; pfam00324 1093787015153 hypothetical protein; Provisional; Region: PRK07036 1093787015154 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1093787015155 inhibitor-cofactor binding pocket; inhibition site 1093787015156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787015157 catalytic residue [active] 1093787015158 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1093787015159 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1093787015160 DNA binding residues [nucleotide binding] 1093787015161 dimerization interface [polypeptide binding]; other site 1093787015162 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1093787015163 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1093787015164 G1 box; other site 1093787015165 putative GEF interaction site [polypeptide binding]; other site 1093787015166 GTP/Mg2+ binding site [chemical binding]; other site 1093787015167 Switch I region; other site 1093787015168 G2 box; other site 1093787015169 G3 box; other site 1093787015170 Switch II region; other site 1093787015171 G4 box; other site 1093787015172 G5 box; other site 1093787015173 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1093787015174 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1093787015175 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1093787015176 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1093787015177 selenocysteine synthase; Provisional; Region: PRK04311 1093787015178 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1093787015179 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1093787015180 catalytic residue [active] 1093787015181 Uncharacterized protein involved in formate dehydrogenase formation [Posttranslational modification, protein turnover, chaperones]; Region: FdhE; COG3058 1093787015182 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1093787015183 Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864 1093787015184 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1093787015185 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1093787015186 4Fe-4S binding domain; Region: Fer4; cl02805 1093787015187 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1093787015188 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1093787015189 molybdopterin cofactor binding site; other site 1093787015190 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1093787015191 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1093787015192 molybdopterin cofactor binding site; other site 1093787015193 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1093787015194 Lipase (class 2); Region: Lipase_2; pfam01674 1093787015195 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1093787015196 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1093787015197 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1093787015198 active site 1093787015199 FMN binding site [chemical binding]; other site 1093787015200 2,4-decadienoyl-CoA binding site; other site 1093787015201 catalytic residue [active] 1093787015202 4Fe-4S cluster binding site [ion binding]; other site 1093787015203 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1093787015204 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1093787015205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1093787015206 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 1093787015207 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1093787015208 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1093787015209 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1093787015210 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1093787015211 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1093787015212 Ligand binding site; other site 1093787015213 Putative Catalytic site; other site 1093787015214 DXD motif; other site 1093787015215 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1093787015216 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1093787015217 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 1093787015218 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1093787015219 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1093787015220 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1093787015221 PhoU domain; Region: PhoU; pfam01895 1093787015222 magnesium-transporting ATPase; Provisional; Region: PRK15122 1093787015223 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1093787015224 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1093787015225 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1093787015226 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1093787015227 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1093787015228 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1093787015229 Predicted membrane protein [Function unknown]; Region: COG3556 1093787015230 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115 1093787015231 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1093787015232 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1093787015233 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1093787015234 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1093787015235 CoenzymeA binding site [chemical binding]; other site 1093787015236 subunit interaction site [polypeptide binding]; other site 1093787015237 PHB binding site; other site 1093787015238 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787015239 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787015240 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1093787015241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787015242 NAD(P) binding site [chemical binding]; other site 1093787015243 active site 1093787015244 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1093787015245 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1093787015246 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1093787015247 EamA-like transporter family; Region: EamA; pfam00892 1093787015248 EamA-like transporter family; Region: EamA; pfam00892 1093787015249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 1093787015250 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 1093787015251 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1093787015252 Nicotianamine synthase protein; Region: NAS; cl17658 1093787015253 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1093787015254 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1093787015255 N-terminal plug; other site 1093787015256 ligand-binding site [chemical binding]; other site 1093787015257 Predicted membrane protein [Function unknown]; Region: COG3503 1093787015258 arginine decarboxylase; Provisional; Region: PRK05354 1093787015259 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1093787015260 dimer interface [polypeptide binding]; other site 1093787015261 active site 1093787015262 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1093787015263 catalytic residues [active] 1093787015264 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1093787015265 translation initiation factor Sui1; Validated; Region: PRK06824 1093787015266 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1093787015267 putative rRNA binding site [nucleotide binding]; other site 1093787015268 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1093787015269 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1093787015270 nudix motif; other site 1093787015271 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095 1093787015272 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 1093787015273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787015274 active site 1093787015275 phosphorylation site [posttranslational modification] 1093787015276 intermolecular recognition site; other site 1093787015277 dimerization interface [polypeptide binding]; other site 1093787015278 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787015279 metal binding site [ion binding]; metal-binding site 1093787015280 active site 1093787015281 I-site; other site 1093787015282 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1093787015283 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787015284 dimer interface [polypeptide binding]; other site 1093787015285 putative CheW interface [polypeptide binding]; other site 1093787015286 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1093787015287 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1093787015288 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1093787015289 DsbD alpha interface [polypeptide binding]; other site 1093787015290 catalytic residues [active] 1093787015291 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1093787015292 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1093787015293 active site 1093787015294 trimer interface [polypeptide binding]; other site 1093787015295 dimer interface [polypeptide binding]; other site 1093787015296 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1093787015297 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1093787015298 carboxyltransferase (CT) interaction site; other site 1093787015299 biotinylation site [posttranslational modification]; other site 1093787015300 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1093787015301 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1093787015302 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1093787015303 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1093787015304 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1093787015305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787015306 S-adenosylmethionine binding site [chemical binding]; other site 1093787015307 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 1093787015308 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 1093787015309 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1093787015310 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1093787015311 FMN binding site [chemical binding]; other site 1093787015312 active site 1093787015313 catalytic residues [active] 1093787015314 substrate binding site [chemical binding]; other site 1093787015315 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1093787015316 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1093787015317 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1093787015318 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1093787015319 purine monophosphate binding site [chemical binding]; other site 1093787015320 dimer interface [polypeptide binding]; other site 1093787015321 putative catalytic residues [active] 1093787015322 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1093787015323 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1093787015324 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1093787015325 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1093787015326 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1093787015327 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1093787015328 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1093787015329 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1093787015330 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787015331 dimer interface [polypeptide binding]; other site 1093787015332 phosphorylation site [posttranslational modification] 1093787015333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787015334 ATP binding site [chemical binding]; other site 1093787015335 Mg2+ binding site [ion binding]; other site 1093787015336 G-X-G motif; other site 1093787015337 Response regulator receiver domain; Region: Response_reg; pfam00072 1093787015338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787015339 active site 1093787015340 phosphorylation site [posttranslational modification] 1093787015341 intermolecular recognition site; other site 1093787015342 dimerization interface [polypeptide binding]; other site 1093787015343 Response regulator receiver domain; Region: Response_reg; pfam00072 1093787015344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787015345 active site 1093787015346 phosphorylation site [posttranslational modification] 1093787015347 intermolecular recognition site; other site 1093787015348 dimerization interface [polypeptide binding]; other site 1093787015349 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1093787015350 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1093787015351 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1093787015352 putative ligand binding site [chemical binding]; other site 1093787015353 HEAT repeats; Region: HEAT_2; pfam13646 1093787015354 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1093787015355 TM-ABC transporter signature motif; other site 1093787015356 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1093787015357 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1093787015358 TM-ABC transporter signature motif; other site 1093787015359 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1093787015360 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1093787015361 Walker A/P-loop; other site 1093787015362 ATP binding site [chemical binding]; other site 1093787015363 Q-loop/lid; other site 1093787015364 ABC transporter signature motif; other site 1093787015365 Walker B; other site 1093787015366 D-loop; other site 1093787015367 H-loop/switch region; other site 1093787015368 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1093787015369 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1093787015370 Walker A/P-loop; other site 1093787015371 ATP binding site [chemical binding]; other site 1093787015372 Q-loop/lid; other site 1093787015373 ABC transporter signature motif; other site 1093787015374 Walker B; other site 1093787015375 D-loop; other site 1093787015376 H-loop/switch region; other site 1093787015377 putative acetyltransferase; Provisional; Region: PRK03624 1093787015378 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787015379 Coenzyme A binding pocket [chemical binding]; other site 1093787015380 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1093787015381 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1093787015382 alpha-gamma subunit interface [polypeptide binding]; other site 1093787015383 beta-gamma subunit interface [polypeptide binding]; other site 1093787015384 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1093787015385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787015386 Coenzyme A binding pocket [chemical binding]; other site 1093787015387 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1093787015388 gamma-beta subunit interface [polypeptide binding]; other site 1093787015389 alpha-beta subunit interface [polypeptide binding]; other site 1093787015390 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1093787015391 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1093787015392 subunit interactions [polypeptide binding]; other site 1093787015393 active site 1093787015394 flap region; other site 1093787015395 hypothetical protein; Provisional; Region: PRK11019 1093787015396 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1093787015397 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1093787015398 tetramer interface [polypeptide binding]; other site 1093787015399 active site 1093787015400 Mg2+/Mn2+ binding site [ion binding]; other site 1093787015401 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1093787015402 putative chaperone; Provisional; Region: PRK11678 1093787015403 nucleotide binding site [chemical binding]; other site 1093787015404 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1093787015405 SBD interface [polypeptide binding]; other site 1093787015406 psiF repeat; Region: PsiF_repeat; pfam07769 1093787015407 psiF repeat; Region: PsiF_repeat; pfam07769 1093787015408 psiF repeat; Region: PsiF_repeat; pfam07769 1093787015409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1093787015410 MOSC domain; Region: MOSC; pfam03473 1093787015411 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 1093787015412 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1093787015413 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1093787015414 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1093787015415 DNA binding residues [nucleotide binding] 1093787015416 drug binding residues [chemical binding]; other site 1093787015417 dimer interface [polypeptide binding]; other site 1093787015418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1093787015419 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1093787015420 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1093787015421 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1093787015422 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1093787015423 dinuclear metal binding motif [ion binding]; other site 1093787015424 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1093787015425 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 1093787015426 Moco binding site; other site 1093787015427 metal coordination site [ion binding]; other site 1093787015428 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1093787015429 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1093787015430 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1093787015431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787015432 active site 1093787015433 phosphorylation site [posttranslational modification] 1093787015434 intermolecular recognition site; other site 1093787015435 dimerization interface [polypeptide binding]; other site 1093787015436 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787015437 DNA binding site [nucleotide binding] 1093787015438 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1093787015439 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787015440 dimerization interface [polypeptide binding]; other site 1093787015441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787015442 dimer interface [polypeptide binding]; other site 1093787015443 phosphorylation site [posttranslational modification] 1093787015444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787015445 ATP binding site [chemical binding]; other site 1093787015446 Mg2+ binding site [ion binding]; other site 1093787015447 G-X-G motif; other site 1093787015448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787015449 putative MFS family transporter protein; Provisional; Region: PRK03633 1093787015450 putative substrate translocation pore; other site 1093787015451 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1093787015452 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1093787015453 putative di-iron ligands [ion binding]; other site 1093787015454 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1093787015455 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1093787015456 FAD binding pocket [chemical binding]; other site 1093787015457 FAD binding motif [chemical binding]; other site 1093787015458 phosphate binding motif [ion binding]; other site 1093787015459 beta-alpha-beta structure motif; other site 1093787015460 NAD binding pocket [chemical binding]; other site 1093787015461 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1093787015462 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1093787015463 catalytic loop [active] 1093787015464 iron binding site [ion binding]; other site 1093787015465 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1093787015466 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787015467 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1093787015468 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1093787015469 dimer interface [polypeptide binding]; other site 1093787015470 catalytic residues [active] 1093787015471 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1093787015472 UreF; Region: UreF; pfam01730 1093787015473 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1093787015474 G1 box; other site 1093787015475 GTP/Mg2+ binding site [chemical binding]; other site 1093787015476 G2 box; other site 1093787015477 Switch I region; other site 1093787015478 G3 box; other site 1093787015479 Switch II region; other site 1093787015480 G4 box; other site 1093787015481 G5 box; other site 1093787015482 HupE / UreJ protein; Region: HupE_UreJ; cl01011 1093787015483 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1093787015484 FecR protein; Region: FecR; pfam04773 1093787015485 RNA polymerase sigma factor; Provisional; Region: PRK12529 1093787015486 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1093787015487 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1093787015488 DNA binding residues [nucleotide binding] 1093787015489 Secretin and TonB N terminus short domain; Region: STN; smart00965 1093787015490 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1093787015491 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1093787015492 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1093787015493 outer membrane porin, OprD family; Region: OprD; pfam03573 1093787015494 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1093787015495 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1093787015496 NAD(P) binding site [chemical binding]; other site 1093787015497 catalytic residues [active] 1093787015498 benzoate transport; Region: 2A0115; TIGR00895 1093787015499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787015500 putative substrate translocation pore; other site 1093787015501 benzoylformate decarboxylase; Reviewed; Region: PRK07092 1093787015502 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1093787015503 PYR/PP interface [polypeptide binding]; other site 1093787015504 dimer interface [polypeptide binding]; other site 1093787015505 TPP binding site [chemical binding]; other site 1093787015506 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1093787015507 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1093787015508 TPP-binding site [chemical binding]; other site 1093787015509 dimer interface [polypeptide binding]; other site 1093787015510 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787015511 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787015512 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 1093787015513 substrate binding pocket [chemical binding]; other site 1093787015514 dimerization interface [polypeptide binding]; other site 1093787015515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787015516 putative substrate translocation pore; other site 1093787015517 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1093787015518 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1093787015519 iron-sulfur cluster [ion binding]; other site 1093787015520 [2Fe-2S] cluster binding site [ion binding]; other site 1093787015521 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 1093787015522 alpha subunit interface [polypeptide binding]; other site 1093787015523 active site 1093787015524 substrate binding site [chemical binding]; other site 1093787015525 Fe binding site [ion binding]; other site 1093787015526 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1093787015527 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1093787015528 FMN-binding pocket [chemical binding]; other site 1093787015529 flavin binding motif; other site 1093787015530 phosphate binding motif [ion binding]; other site 1093787015531 beta-alpha-beta structure motif; other site 1093787015532 NAD binding pocket [chemical binding]; other site 1093787015533 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1093787015534 catalytic loop [active] 1093787015535 iron binding site [ion binding]; other site 1093787015536 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787015537 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1093787015538 DNA-binding site [nucleotide binding]; DNA binding site 1093787015539 FCD domain; Region: FCD; pfam07729 1093787015540 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1093787015541 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1093787015542 putative NAD(P) binding site [chemical binding]; other site 1093787015543 homodimer interface [polypeptide binding]; other site 1093787015544 homotetramer interface [polypeptide binding]; other site 1093787015545 active site 1093787015546 ornithine cyclodeaminase; Validated; Region: PRK06141 1093787015547 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1093787015548 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1093787015549 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1093787015550 Walker A/P-loop; other site 1093787015551 ATP binding site [chemical binding]; other site 1093787015552 Q-loop/lid; other site 1093787015553 ABC transporter signature motif; other site 1093787015554 Walker B; other site 1093787015555 D-loop; other site 1093787015556 H-loop/switch region; other site 1093787015557 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1093787015558 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1093787015559 Walker A/P-loop; other site 1093787015560 ATP binding site [chemical binding]; other site 1093787015561 Q-loop/lid; other site 1093787015562 ABC transporter signature motif; other site 1093787015563 Walker B; other site 1093787015564 D-loop; other site 1093787015565 H-loop/switch region; other site 1093787015566 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1093787015567 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1093787015568 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1093787015569 TM-ABC transporter signature motif; other site 1093787015570 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1093787015571 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1093787015572 TM-ABC transporter signature motif; other site 1093787015573 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1093787015574 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1093787015575 dimerization interface [polypeptide binding]; other site 1093787015576 ligand binding site [chemical binding]; other site 1093787015577 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1093787015578 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787015579 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787015580 dimerization interface [polypeptide binding]; other site 1093787015581 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1093787015582 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787015583 dimerization interface [polypeptide binding]; other site 1093787015584 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1093787015585 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787015586 dimer interface [polypeptide binding]; other site 1093787015587 putative CheW interface [polypeptide binding]; other site 1093787015588 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1093787015589 nudix motif; other site 1093787015590 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 1093787015591 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 1093787015592 active site 1093787015593 nucleotide binding site [chemical binding]; other site 1093787015594 HIGH motif; other site 1093787015595 KMSKS motif; other site 1093787015596 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1093787015597 Isochorismatase family; Region: Isochorismatase; pfam00857 1093787015598 catalytic triad [active] 1093787015599 metal binding site [ion binding]; metal-binding site 1093787015600 conserved cis-peptide bond; other site 1093787015601 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1093787015602 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1093787015603 active site 1093787015604 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1093787015605 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1093787015606 homodimer interface [polypeptide binding]; other site 1093787015607 NAD binding pocket [chemical binding]; other site 1093787015608 ATP binding pocket [chemical binding]; other site 1093787015609 Mg binding site [ion binding]; other site 1093787015610 active-site loop [active] 1093787015611 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1093787015612 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 1093787015613 active site 1093787015614 catalytic triad [active] 1093787015615 oxyanion hole [active] 1093787015616 Azurin [Energy production and conversion]; Region: COG3241 1093787015617 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1093787015618 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1093787015619 Peptidase family M23; Region: Peptidase_M23; pfam01551 1093787015620 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1093787015621 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1093787015622 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1093787015623 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1093787015624 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1093787015625 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1093787015626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1093787015627 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1093787015628 hypothetical protein; Provisional; Region: PRK01254 1093787015629 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1093787015630 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1093787015631 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1093787015632 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1093787015633 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787015634 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787015635 metal binding site [ion binding]; metal-binding site 1093787015636 active site 1093787015637 I-site; other site 1093787015638 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1093787015639 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1093787015640 active site 1093787015641 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1093787015642 substrate binding site [chemical binding]; other site 1093787015643 catalytic residues [active] 1093787015644 dimer interface [polypeptide binding]; other site 1093787015645 replicative DNA helicase; Provisional; Region: PRK05748 1093787015646 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1093787015647 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1093787015648 Walker A motif; other site 1093787015649 ATP binding site [chemical binding]; other site 1093787015650 Walker B motif; other site 1093787015651 DNA binding loops [nucleotide binding] 1093787015652 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1093787015653 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1093787015654 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1093787015655 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1093787015656 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1093787015657 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1093787015658 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1093787015659 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1093787015660 exoribonuclease R; Provisional; Region: PRK11642 1093787015661 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1093787015662 RNB domain; Region: RNB; pfam00773 1093787015663 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1093787015664 RNA binding site [nucleotide binding]; other site 1093787015665 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1093787015666 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1093787015667 GDP-binding site [chemical binding]; other site 1093787015668 ACT binding site; other site 1093787015669 IMP binding site; other site 1093787015670 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 1093787015671 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1093787015672 dimer interface [polypeptide binding]; other site 1093787015673 motif 1; other site 1093787015674 active site 1093787015675 motif 2; other site 1093787015676 motif 3; other site 1093787015677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1093787015678 FtsH protease regulator HflC; Provisional; Region: PRK11029 1093787015679 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1093787015680 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1093787015681 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1093787015682 HflK protein; Region: hflK; TIGR01933 1093787015683 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1093787015684 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1093787015685 HflX GTPase family; Region: HflX; cd01878 1093787015686 G1 box; other site 1093787015687 GTP/Mg2+ binding site [chemical binding]; other site 1093787015688 Switch I region; other site 1093787015689 G2 box; other site 1093787015690 G3 box; other site 1093787015691 Switch II region; other site 1093787015692 G4 box; other site 1093787015693 G5 box; other site 1093787015694 bacterial Hfq-like; Region: Hfq; cd01716 1093787015695 hexamer interface [polypeptide binding]; other site 1093787015696 Sm1 motif; other site 1093787015697 RNA binding site [nucleotide binding]; other site 1093787015698 Sm2 motif; other site 1093787015699 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1093787015700 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1093787015701 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1093787015702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787015703 ATP binding site [chemical binding]; other site 1093787015704 Mg2+ binding site [ion binding]; other site 1093787015705 G-X-G motif; other site 1093787015706 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1093787015707 ATP binding site [chemical binding]; other site 1093787015708 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1093787015709 AMIN domain; Region: AMIN; pfam11741 1093787015710 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1093787015711 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1093787015712 active site 1093787015713 metal binding site [ion binding]; metal-binding site 1093787015714 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1093787015715 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1093787015716 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1093787015717 putative carbohydrate kinase; Provisional; Region: PRK10565 1093787015718 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1093787015719 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1093787015720 putative substrate binding site [chemical binding]; other site 1093787015721 putative ATP binding site [chemical binding]; other site 1093787015722 epoxyqueuosine reductase; Region: TIGR00276 1093787015723 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1093787015724 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1093787015725 catalytic site [active] 1093787015726 putative active site [active] 1093787015727 putative substrate binding site [chemical binding]; other site 1093787015728 dimer interface [polypeptide binding]; other site 1093787015729 GTPase RsgA; Reviewed; Region: PRK12288 1093787015730 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1093787015731 RNA binding site [nucleotide binding]; other site 1093787015732 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1093787015733 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1093787015734 GTP/Mg2+ binding site [chemical binding]; other site 1093787015735 G4 box; other site 1093787015736 G5 box; other site 1093787015737 G1 box; other site 1093787015738 Switch I region; other site 1093787015739 G2 box; other site 1093787015740 G3 box; other site 1093787015741 Switch II region; other site 1093787015742 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1093787015743 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1093787015744 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1093787015745 ligand binding site [chemical binding]; other site 1093787015746 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1093787015747 flagellar motor protein MotA; Validated; Region: PRK09110 1093787015748 HDOD domain; Region: HDOD; pfam08668 1093787015749 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1093787015750 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1093787015751 active site residue [active] 1093787015752 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1093787015753 active site residue [active] 1093787015754 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1093787015755 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1093787015756 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1093787015757 active site 1093787015758 phosphorylation site [posttranslational modification] 1093787015759 dimerization interface [polypeptide binding]; other site 1093787015760 PAS fold; Region: PAS; pfam00989 1093787015761 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787015762 putative active site [active] 1093787015763 heme pocket [chemical binding]; other site 1093787015764 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787015765 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787015766 metal binding site [ion binding]; metal-binding site 1093787015767 active site 1093787015768 I-site; other site 1093787015769 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1093787015770 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1093787015771 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1093787015772 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1093787015773 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1093787015774 motif II; other site 1093787015775 Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726 1093787015776 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1093787015777 metal binding site [ion binding]; metal-binding site 1093787015778 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1093787015779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1093787015780 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1093787015781 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1093787015782 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1093787015783 CAP-like domain; other site 1093787015784 active site 1093787015785 primary dimer interface [polypeptide binding]; other site 1093787015786 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1093787015787 catalytic motif [active] 1093787015788 Catalytic residue [active] 1093787015789 SdiA-regulated; Region: SdiA-regulated; cd09971 1093787015790 putative active site [active] 1093787015791 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1093787015792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787015793 ATP binding site [chemical binding]; other site 1093787015794 Mg2+ binding site [ion binding]; other site 1093787015795 G-X-G motif; other site 1093787015796 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1093787015797 anchoring element; other site 1093787015798 dimer interface [polypeptide binding]; other site 1093787015799 ATP binding site [chemical binding]; other site 1093787015800 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1093787015801 active site 1093787015802 metal binding site [ion binding]; metal-binding site 1093787015803 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1093787015804 Predicted esterase [General function prediction only]; Region: COG3150 1093787015805 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1093787015806 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1093787015807 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1093787015808 active site 1093787015809 metal binding site [ion binding]; metal-binding site 1093787015810 hexamer interface [polypeptide binding]; other site 1093787015811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3151 1093787015812 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1093787015813 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1093787015814 dimer interface [polypeptide binding]; other site 1093787015815 ADP-ribose binding site [chemical binding]; other site 1093787015816 active site 1093787015817 nudix motif; other site 1093787015818 metal binding site [ion binding]; metal-binding site 1093787015819 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1093787015820 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1093787015821 ThiC-associated domain; Region: ThiC-associated; pfam13667 1093787015822 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1093787015823 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1093787015824 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1093787015825 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1093787015826 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1093787015827 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1093787015828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787015829 homodimer interface [polypeptide binding]; other site 1093787015830 catalytic residue [active] 1093787015831 hypothetical protein; Provisional; Region: PRK07524 1093787015832 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1093787015833 PYR/PP interface [polypeptide binding]; other site 1093787015834 dimer interface [polypeptide binding]; other site 1093787015835 TPP binding site [chemical binding]; other site 1093787015836 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1093787015837 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1093787015838 TPP-binding site [chemical binding]; other site 1093787015839 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1093787015840 CoA binding domain; Region: CoA_binding_2; pfam13380 1093787015841 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1093787015842 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1093787015843 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1093787015844 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787015845 active site 1093787015846 enoyl-CoA hydratase; Provisional; Region: PRK06688 1093787015847 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1093787015848 substrate binding site [chemical binding]; other site 1093787015849 oxyanion hole (OAH) forming residues; other site 1093787015850 trimer interface [polypeptide binding]; other site 1093787015851 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1093787015852 S-methylmethionine transporter; Provisional; Region: PRK11387 1093787015853 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1093787015854 HAMP domain; Region: HAMP; pfam00672 1093787015855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787015856 dimer interface [polypeptide binding]; other site 1093787015857 phosphorylation site [posttranslational modification] 1093787015858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787015859 ATP binding site [chemical binding]; other site 1093787015860 Mg2+ binding site [ion binding]; other site 1093787015861 G-X-G motif; other site 1093787015862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787015863 Response regulator receiver domain; Region: Response_reg; pfam00072 1093787015864 active site 1093787015865 phosphorylation site [posttranslational modification] 1093787015866 intermolecular recognition site; other site 1093787015867 dimerization interface [polypeptide binding]; other site 1093787015868 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1093787015869 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787015870 substrate binding pocket [chemical binding]; other site 1093787015871 membrane-bound complex binding site; other site 1093787015872 hinge residues; other site 1093787015873 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 1093787015874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787015875 active site 1093787015876 phosphorylation site [posttranslational modification] 1093787015877 intermolecular recognition site; other site 1093787015878 dimerization interface [polypeptide binding]; other site 1093787015879 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787015880 DNA binding site [nucleotide binding] 1093787015881 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1093787015882 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787015883 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1093787015884 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1093787015885 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1093787015886 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1093787015887 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 1093787015888 putative active site [active] 1093787015889 putative FMN binding site [chemical binding]; other site 1093787015890 putative substrate binding site [chemical binding]; other site 1093787015891 putative catalytic residue [active] 1093787015892 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1093787015893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1093787015894 non-specific DNA binding site [nucleotide binding]; other site 1093787015895 salt bridge; other site 1093787015896 sequence-specific DNA binding site [nucleotide binding]; other site 1093787015897 Cupin domain; Region: Cupin_2; pfam07883 1093787015898 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1093787015899 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1093787015900 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1093787015901 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787015902 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787015903 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1093787015904 dimerization interface [polypeptide binding]; other site 1093787015905 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1093787015906 FAD dependent oxidoreductase; Region: DAO; pfam01266 1093787015907 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1093787015908 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1093787015909 active site 1093787015910 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1093787015911 catalytic tetrad [active] 1093787015912 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1093787015913 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787015914 active site 1093787015915 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1093787015916 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787015917 active site 1093787015918 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1093787015919 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1093787015920 putative ribose interaction site [chemical binding]; other site 1093787015921 putative ADP binding site [chemical binding]; other site 1093787015922 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1093787015923 active site 1093787015924 nucleotide binding site [chemical binding]; other site 1093787015925 HIGH motif; other site 1093787015926 KMSKS motif; other site 1093787015927 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1093787015928 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1093787015929 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1093787015930 Walker A/P-loop; other site 1093787015931 ATP binding site [chemical binding]; other site 1093787015932 Q-loop/lid; other site 1093787015933 ABC transporter signature motif; other site 1093787015934 Walker B; other site 1093787015935 D-loop; other site 1093787015936 H-loop/switch region; other site 1093787015937 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1093787015938 active site 1093787015939 substrate binding site [chemical binding]; other site 1093787015940 ATP binding site [chemical binding]; other site 1093787015941 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1093787015942 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1093787015943 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1093787015944 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1093787015945 active site 1093787015946 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1093787015947 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1093787015948 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1093787015949 Mig-14; Region: Mig-14; pfam07395 1093787015950 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1093787015951 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1093787015952 putative ADP-binding pocket [chemical binding]; other site 1093787015953 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1093787015954 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1093787015955 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1093787015956 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1093787015957 active site 1093787015958 ATP binding site [chemical binding]; other site 1093787015959 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1093787015960 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293 1093787015961 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1093787015962 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 1093787015963 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1093787015964 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1093787015965 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1093787015966 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1093787015967 putative active site [active] 1093787015968 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1093787015969 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1093787015970 putative active site [active] 1093787015971 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1093787015972 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1093787015973 homodimer interface [polypeptide binding]; other site 1093787015974 substrate-cofactor binding pocket; other site 1093787015975 catalytic residue [active] 1093787015976 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1093787015977 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1093787015978 metal binding triad; other site 1093787015979 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1093787015980 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1093787015981 metal binding triad; other site 1093787015982 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1093787015983 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1093787015984 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1093787015985 dimer interface [polypeptide binding]; other site 1093787015986 TPP-binding site [chemical binding]; other site 1093787015987 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1093787015988 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_long; TIGR01348 1093787015989 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1093787015990 E3 interaction surface; other site 1093787015991 lipoyl attachment site [posttranslational modification]; other site 1093787015992 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1093787015993 E3 interaction surface; other site 1093787015994 lipoyl attachment site [posttranslational modification]; other site 1093787015995 e3 binding domain; Region: E3_binding; pfam02817 1093787015996 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1093787015997 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1093787015998 GAF domain; Region: GAF; pfam01590 1093787015999 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787016000 PAS domain; Region: PAS_9; pfam13426 1093787016001 putative active site [active] 1093787016002 heme pocket [chemical binding]; other site 1093787016003 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787016004 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787016005 metal binding site [ion binding]; metal-binding site 1093787016006 active site 1093787016007 I-site; other site 1093787016008 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1093787016009 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1093787016010 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1093787016011 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1093787016012 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1093787016013 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787016014 active site 1093787016015 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1093787016016 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1093787016017 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1093787016018 TrkA-C domain; Region: TrkA_C; pfam02080 1093787016019 Transporter associated domain; Region: CorC_HlyC; smart01091 1093787016020 hypothetical protein; Provisional; Region: PRK11281 1093787016021 Vegetative insecticide protein 3A N terminal; Region: Vip3A_N; pfam12495 1093787016022 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1093787016023 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1093787016024 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1093787016025 hypothetical protein; Validated; Region: PRK00029 1093787016026 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1093787016027 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 1093787016028 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1093787016029 homodimer interface [polypeptide binding]; other site 1093787016030 substrate-cofactor binding pocket; other site 1093787016031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787016032 catalytic residue [active] 1093787016033 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1093787016034 CoenzymeA binding site [chemical binding]; other site 1093787016035 subunit interaction site [polypeptide binding]; other site 1093787016036 PHB binding site; other site 1093787016037 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1093787016038 Ligand Binding Site [chemical binding]; other site 1093787016039 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1093787016040 Ligand Binding Site [chemical binding]; other site 1093787016041 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1093787016042 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1093787016043 P-loop; other site 1093787016044 Magnesium ion binding site [ion binding]; other site 1093787016045 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1093787016046 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1093787016047 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787016048 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1093787016049 dimerization interface [polypeptide binding]; other site 1093787016050 substrate binding pocket [chemical binding]; other site 1093787016051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787016052 putative substrate translocation pore; other site 1093787016053 short chain dehydrogenase; Provisional; Region: PRK06197 1093787016054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787016055 NAD(P) binding site [chemical binding]; other site 1093787016056 active site 1093787016057 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1093787016058 Helix-turn-helix domain; Region: HTH_18; pfam12833 1093787016059 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787016060 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1093787016061 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1093787016062 substrate binding site [chemical binding]; other site 1093787016063 active site 1093787016064 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1093787016065 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1093787016066 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1093787016067 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1093787016068 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1093787016069 active site 1093787016070 dimer interface [polypeptide binding]; other site 1093787016071 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1093787016072 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1093787016073 active site 1093787016074 FMN binding site [chemical binding]; other site 1093787016075 substrate binding site [chemical binding]; other site 1093787016076 3Fe-4S cluster binding site [ion binding]; other site 1093787016077 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1093787016078 domain interface; other site 1093787016079 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1093787016080 AAA ATPase domain; Region: AAA_16; pfam13191 1093787016081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 1093787016082 Sporulation related domain; Region: SPOR; pfam05036 1093787016083 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1093787016084 active site 1093787016085 dimer interface [polypeptide binding]; other site 1093787016086 metal binding site [ion binding]; metal-binding site 1093787016087 shikimate kinase; Reviewed; Region: aroK; PRK00131 1093787016088 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1093787016089 ADP binding site [chemical binding]; other site 1093787016090 magnesium binding site [ion binding]; other site 1093787016091 putative shikimate binding site; other site 1093787016092 AMIN domain; Region: AMIN; pfam11741 1093787016093 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1093787016094 Secretin and TonB N terminus short domain; Region: STN; smart00965 1093787016095 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1093787016096 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1093787016097 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 1093787016098 Pilus assembly protein, PilP; Region: PilP; pfam04351 1093787016099 Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilO; COG3167 1093787016100 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1093787016101 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1093787016102 Competence protein A; Region: Competence_A; pfam11104 1093787016103 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1093787016104 nucleotide binding site [chemical binding]; other site 1093787016105 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1093787016106 Transglycosylase; Region: Transgly; pfam00912 1093787016107 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1093787016108 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1093787016109 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1093787016110 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1093787016111 putative NAD(P) binding site [chemical binding]; other site 1093787016112 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 1093787016113 Peptidase family M48; Region: Peptidase_M48; pfam01435 1093787016114 Staphylococcal nuclease homologues; Region: SNc; smart00318 1093787016115 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1093787016116 Catalytic site; other site 1093787016117 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1093787016118 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1093787016119 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1093787016120 ATP binding site [chemical binding]; other site 1093787016121 putative Mg++ binding site [ion binding]; other site 1093787016122 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1093787016123 nucleotide binding region [chemical binding]; other site 1093787016124 ATP-binding site [chemical binding]; other site 1093787016125 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1093787016126 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1093787016127 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1093787016128 active site 1093787016129 HIGH motif; other site 1093787016130 KMSK motif region; other site 1093787016131 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1093787016132 tRNA binding surface [nucleotide binding]; other site 1093787016133 anticodon binding site; other site 1093787016134 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 1093787016135 Sporulation related domain; Region: SPOR; pfam05036 1093787016136 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1093787016137 active site 1093787016138 HslU subunit interaction site [polypeptide binding]; other site 1093787016139 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1093787016140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787016141 Walker A motif; other site 1093787016142 ATP binding site [chemical binding]; other site 1093787016143 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1093787016144 Walker B motif; other site 1093787016145 arginine finger; other site 1093787016146 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1093787016147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 1093787016148 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 1093787016149 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1093787016150 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 1093787016151 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1093787016152 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 1093787016153 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1093787016154 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1093787016155 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787016156 Bacterial transcriptional repressor; Region: TetR; pfam13972 1093787016157 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 1093787016158 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 1093787016159 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 1093787016160 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1093787016161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787016162 S-adenosylmethionine binding site [chemical binding]; other site 1093787016163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1093787016164 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1093787016165 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1093787016166 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1093787016167 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1093787016168 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1093787016169 metal binding site [ion binding]; metal-binding site 1093787016170 twin arginine translocase protein A; Provisional; Region: tatA; PRK00442 1093787016171 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1093787016172 sec-independent translocase; Provisional; Region: tatB; PRK00404 1093787016173 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 1093787016174 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1093787016175 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1093787016176 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1093787016177 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1093787016178 dimer interface [polypeptide binding]; other site 1093787016179 putative CheW interface [polypeptide binding]; other site 1093787016180 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 1093787016181 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1093787016182 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1093787016183 Walker A/P-loop; other site 1093787016184 ATP binding site [chemical binding]; other site 1093787016185 Q-loop/lid; other site 1093787016186 ABC transporter signature motif; other site 1093787016187 Walker B; other site 1093787016188 D-loop; other site 1093787016189 H-loop/switch region; other site 1093787016190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787016191 ABC-ATPase subunit interface; other site 1093787016192 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1093787016193 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787016194 substrate binding pocket [chemical binding]; other site 1093787016195 membrane-bound complex binding site; other site 1093787016196 hinge residues; other site 1093787016197 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1093787016198 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1093787016199 Ligand binding site; other site 1093787016200 DXD motif; other site 1093787016201 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1093787016202 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 1093787016203 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1093787016204 putative active site [active] 1093787016205 dimerization interface [polypeptide binding]; other site 1093787016206 putative tRNAtyr binding site [nucleotide binding]; other site 1093787016207 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1093787016208 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1093787016209 TAP-like protein; Region: Abhydrolase_4; pfam08386 1093787016210 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1093787016211 nudix motif; other site 1093787016212 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1093787016213 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787016214 substrate binding pocket [chemical binding]; other site 1093787016215 membrane-bound complex binding site; other site 1093787016216 hinge residues; other site 1093787016217 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1093787016218 homotrimer interaction site [polypeptide binding]; other site 1093787016219 putative active site [active] 1093787016220 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1093787016221 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1093787016222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787016223 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787016224 dimerization interface [polypeptide binding]; other site 1093787016225 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1093787016226 Sel1-like repeats; Region: SEL1; smart00671 1093787016227 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1093787016228 Sel1 repeat; Region: Sel1; cl02723 1093787016229 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1093787016230 Sel1 repeat; Region: Sel1; cl02723 1093787016231 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1093787016232 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1093787016233 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1093787016234 putative active site [active] 1093787016235 catalytic site [active] 1093787016236 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1093787016237 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1093787016238 putative active site [active] 1093787016239 catalytic site [active] 1093787016240 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1093787016241 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1093787016242 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1093787016243 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1093787016244 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1093787016245 imidazolonepropionase; Validated; Region: PRK09356 1093787016246 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1093787016247 active site 1093787016248 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1093787016249 active sites [active] 1093787016250 tetramer interface [polypeptide binding]; other site 1093787016251 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1093787016252 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1093787016253 Walker A/P-loop; other site 1093787016254 ATP binding site [chemical binding]; other site 1093787016255 Q-loop/lid; other site 1093787016256 ABC transporter signature motif; other site 1093787016257 Walker B; other site 1093787016258 D-loop; other site 1093787016259 H-loop/switch region; other site 1093787016260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787016261 dimer interface [polypeptide binding]; other site 1093787016262 conserved gate region; other site 1093787016263 putative PBP binding loops; other site 1093787016264 ABC-ATPase subunit interface; other site 1093787016265 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1093787016266 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1093787016267 putative proline-specific permease; Provisional; Region: proY; PRK10580 1093787016268 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1093787016269 active sites [active] 1093787016270 tetramer interface [polypeptide binding]; other site 1093787016271 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1093787016272 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1093787016273 Na binding site [ion binding]; other site 1093787016274 urocanate hydratase; Provisional; Region: PRK05414 1093787016275 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1093787016276 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1093787016277 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1093787016278 putative di-iron ligands [ion binding]; other site 1093787016279 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1093787016280 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1093787016281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758 1093787016282 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1093787016283 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787016284 DNA-binding site [nucleotide binding]; DNA binding site 1093787016285 UTRA domain; Region: UTRA; pfam07702 1093787016286 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1093787016287 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 1093787016288 active site 1093787016289 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 1093787016290 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1093787016291 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1093787016292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 1093787016293 fructose-1,6-bisphosphatase family protein; Region: PLN02628 1093787016294 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1093787016295 AMP binding site [chemical binding]; other site 1093787016296 metal binding site [ion binding]; metal-binding site 1093787016297 active site 1093787016298 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1093787016299 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1093787016300 dimer interface [polypeptide binding]; other site 1093787016301 active site 1093787016302 metal binding site [ion binding]; metal-binding site 1093787016303 glutathione binding site [chemical binding]; other site 1093787016304 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1093787016305 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 1093787016306 active site 1093787016307 catalytic triad [active] 1093787016308 oxyanion hole [active] 1093787016309 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1093787016310 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 1093787016311 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 1093787016312 Predicted membrane protein [Function unknown]; Region: COG5373 1093787016313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787016314 S-adenosylmethionine binding site [chemical binding]; other site 1093787016315 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 1093787016316 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1093787016317 DNA binding residues [nucleotide binding] 1093787016318 putative dimer interface [polypeptide binding]; other site 1093787016319 putative metal binding residues [ion binding]; other site 1093787016320 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1093787016321 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1093787016322 G1 box; other site 1093787016323 putative GEF interaction site [polypeptide binding]; other site 1093787016324 GTP/Mg2+ binding site [chemical binding]; other site 1093787016325 Switch I region; other site 1093787016326 G2 box; other site 1093787016327 G3 box; other site 1093787016328 Switch II region; other site 1093787016329 G4 box; other site 1093787016330 G5 box; other site 1093787016331 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1093787016332 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1093787016333 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1093787016334 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1093787016335 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1093787016336 Ligand Binding Site [chemical binding]; other site 1093787016337 thiazole biosynthesis domain; Region: ThiI_C_thiazole; TIGR04271 1093787016338 glutamine synthetase; Provisional; Region: glnA; PRK09469 1093787016339 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1093787016340 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1093787016341 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1093787016342 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1093787016343 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1093787016344 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1093787016345 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1093787016346 PAS domain; Region: PAS; smart00091 1093787016347 putative active site [active] 1093787016348 heme pocket [chemical binding]; other site 1093787016349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787016350 dimer interface [polypeptide binding]; other site 1093787016351 phosphorylation site [posttranslational modification] 1093787016352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787016353 ATP binding site [chemical binding]; other site 1093787016354 Mg2+ binding site [ion binding]; other site 1093787016355 G-X-G motif; other site 1093787016356 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1093787016357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787016358 active site 1093787016359 phosphorylation site [posttranslational modification] 1093787016360 intermolecular recognition site; other site 1093787016361 dimerization interface [polypeptide binding]; other site 1093787016362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787016363 Walker A motif; other site 1093787016364 ATP binding site [chemical binding]; other site 1093787016365 Walker B motif; other site 1093787016366 arginine finger; other site 1093787016367 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1093787016368 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1093787016369 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1093787016370 SecA binding site; other site 1093787016371 Preprotein binding site; other site 1093787016372 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1093787016373 GSH binding site [chemical binding]; other site 1093787016374 catalytic residues [active] 1093787016375 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1093787016376 active site residue [active] 1093787016377 phosphoglyceromutase; Provisional; Region: PRK05434 1093787016378 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1093787016379 CAAX protease self-immunity; Region: Abi; pfam02517 1093787016380 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1093787016381 Peptidase family M23; Region: Peptidase_M23; pfam01551 1093787016382 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1093787016383 C-terminal peptidase (prc); Region: prc; TIGR00225 1093787016384 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1093787016385 protein binding site [polypeptide binding]; other site 1093787016386 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1093787016387 Catalytic dyad [active] 1093787016388 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1093787016389 NodB motif; other site 1093787016390 putative active site [active] 1093787016391 putative catalytic site [active] 1093787016392 Zn binding site [ion binding]; other site 1093787016393 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 1093787016394 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787016395 substrate binding pocket [chemical binding]; other site 1093787016396 membrane-bound complex binding site; other site 1093787016397 hinge residues; other site 1093787016398 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787016399 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1093787016400 substrate binding pocket [chemical binding]; other site 1093787016401 membrane-bound complex binding site; other site 1093787016402 hinge residues; other site 1093787016403 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787016404 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1093787016405 substrate binding pocket [chemical binding]; other site 1093787016406 membrane-bound complex binding site; other site 1093787016407 hinge residues; other site 1093787016408 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1093787016409 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1093787016410 substrate binding site [chemical binding]; other site 1093787016411 glutamase interaction surface [polypeptide binding]; other site 1093787016412 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1093787016413 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1093787016414 catalytic residues [active] 1093787016415 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 1093787016416 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1093787016417 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1093787016418 putative active site [active] 1093787016419 oxyanion strand; other site 1093787016420 catalytic triad [active] 1093787016421 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1093787016422 putative active site pocket [active] 1093787016423 4-fold oligomerization interface [polypeptide binding]; other site 1093787016424 metal binding residues [ion binding]; metal-binding site 1093787016425 3-fold/trimer interface [polypeptide binding]; other site 1093787016426 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1093787016427 Sec63 Brl domain; Region: Sec63; pfam02889 1093787016428 FAD dependent oxidoreductase; Region: DAO; pfam01266 1093787016429 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1093787016430 AsmA family; Region: AsmA; pfam05170 1093787016431 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1093787016432 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1093787016433 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1093787016434 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1093787016435 minor groove reading motif; other site 1093787016436 helix-hairpin-helix signature motif; other site 1093787016437 substrate binding pocket [chemical binding]; other site 1093787016438 active site 1093787016439 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1093787016440 DNA binding and oxoG recognition site [nucleotide binding] 1093787016441 oxidative damage protection protein; Provisional; Region: PRK05408 1093787016442 putative oxidoreductase; Provisional; Region: PRK11579 1093787016443 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1093787016444 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1093787016445 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1093787016446 classical (c) SDRs; Region: SDR_c; cd05233 1093787016447 NAD(P) binding site [chemical binding]; other site 1093787016448 active site 1093787016449 Uncharacterized conserved protein [Function unknown]; Region: COG2928 1093787016450 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1093787016451 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1093787016452 Walker A/P-loop; other site 1093787016453 ATP binding site [chemical binding]; other site 1093787016454 Q-loop/lid; other site 1093787016455 ABC transporter signature motif; other site 1093787016456 Walker B; other site 1093787016457 D-loop; other site 1093787016458 H-loop/switch region; other site 1093787016459 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1093787016460 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787016461 substrate binding pocket [chemical binding]; other site 1093787016462 membrane-bound complex binding site; other site 1093787016463 hinge residues; other site 1093787016464 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1093787016465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787016466 dimer interface [polypeptide binding]; other site 1093787016467 conserved gate region; other site 1093787016468 putative PBP binding loops; other site 1093787016469 ABC-ATPase subunit interface; other site 1093787016470 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1093787016471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787016472 dimer interface [polypeptide binding]; other site 1093787016473 conserved gate region; other site 1093787016474 putative PBP binding loops; other site 1093787016475 ABC-ATPase subunit interface; other site 1093787016476 Methyltransferase domain; Region: Methyltransf_32; pfam13679 1093787016477 MarR family; Region: MarR_2; cl17246 1093787016478 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1093787016479 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1093787016480 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1093787016481 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1093787016482 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787016483 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1093787016484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787016485 putative substrate translocation pore; other site 1093787016486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787016487 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1093787016488 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1093787016489 NAD binding site [chemical binding]; other site 1093787016490 substrate binding site [chemical binding]; other site 1093787016491 homodimer interface [polypeptide binding]; other site 1093787016492 active site 1093787016493 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 1093787016494 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1093787016495 NADP binding site [chemical binding]; other site 1093787016496 active site 1093787016497 putative substrate binding site [chemical binding]; other site 1093787016498 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1093787016499 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1093787016500 substrate binding site; other site 1093787016501 tetramer interface; other site 1093787016502 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 1093787016503 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1093787016504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787016505 dimer interface [polypeptide binding]; other site 1093787016506 phosphorylation site [posttranslational modification] 1093787016507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787016508 ATP binding site [chemical binding]; other site 1093787016509 Mg2+ binding site [ion binding]; other site 1093787016510 G-X-G motif; other site 1093787016511 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1093787016512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787016513 active site 1093787016514 phosphorylation site [posttranslational modification] 1093787016515 intermolecular recognition site; other site 1093787016516 dimerization interface [polypeptide binding]; other site 1093787016517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787016518 Walker A motif; other site 1093787016519 ATP binding site [chemical binding]; other site 1093787016520 Walker B motif; other site 1093787016521 arginine finger; other site 1093787016522 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1093787016523 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1093787016524 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1093787016525 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1093787016526 DctM-like transporters; Region: DctM; pfam06808 1093787016527 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1093787016528 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1093787016529 arginine deiminase; Provisional; Region: PRK01388 1093787016530 ornithine carbamoyltransferase; Validated; Region: PRK02102 1093787016531 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1093787016532 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1093787016533 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1093787016534 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1093787016535 putative substrate binding site [chemical binding]; other site 1093787016536 nucleotide binding site [chemical binding]; other site 1093787016537 nucleotide binding site [chemical binding]; other site 1093787016538 homodimer interface [polypeptide binding]; other site 1093787016539 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1093787016540 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1093787016541 active site 1093787016542 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1093787016543 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1093787016544 active site 1093787016545 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1093787016546 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1093787016547 dimer interface [polypeptide binding]; other site 1093787016548 ADP-ribose binding site [chemical binding]; other site 1093787016549 active site 1093787016550 nudix motif; other site 1093787016551 metal binding site [ion binding]; metal-binding site 1093787016552 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1093787016553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1093787016554 motif II; other site 1093787016555 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1093787016556 BON domain; Region: BON; pfam04972 1093787016557 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1093787016558 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787016559 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787016560 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1093787016561 dimerization interface [polypeptide binding]; other site 1093787016562 Uncharacterized protein required for formate dehydrogenase activity [Energy production and conversion]; Region: FdhD; COG1526 1093787016563 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1093787016564 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1093787016565 putative molybdopterin cofactor binding site [chemical binding]; other site 1093787016566 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1093787016567 putative molybdopterin cofactor binding site; other site 1093787016568 Global regulator protein family; Region: CsrA; pfam02599 1093787016569 chorismate mutase; Provisional; Region: PRK09269 1093787016570 chorismate mutase, putative; Region: CM_mono2; TIGR01806 1093787016571 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1093787016572 active site 1093787016573 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1093787016574 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 1093787016575 putative active site [active] 1093787016576 metal binding site [ion binding]; metal-binding site 1093787016577 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1093787016578 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1093787016579 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1093787016580 active site 1093787016581 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1093787016582 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1093787016583 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1093787016584 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1093787016585 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1093787016586 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1093787016587 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787016588 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1093787016589 dimerization interface [polypeptide binding]; other site 1093787016590 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1093787016591 dimer interface [polypeptide binding]; other site 1093787016592 FMN binding site [chemical binding]; other site 1093787016593 Fimbrial protein; Region: Fimbrial; cl01416 1093787016594 potential frameshift: common BLAST hit: gi|218894294|ref|YP_002443164.1| phosphoenolpyruvate carboxykinase 1093787016595 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1093787016596 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1093787016597 dimerization interface [polypeptide binding]; other site 1093787016598 domain crossover interface; other site 1093787016599 redox-dependent activation switch; other site 1093787016600 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1093787016601 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1093787016602 active site 1093787016603 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1093787016604 RNA binding surface [nucleotide binding]; other site 1093787016605 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1093787016606 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1093787016607 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1093787016608 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1093787016609 dimer interface [polypeptide binding]; other site 1093787016610 catalytic triad [active] 1093787016611 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1093787016612 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787016613 dimerization interface [polypeptide binding]; other site 1093787016614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787016615 ATP binding site [chemical binding]; other site 1093787016616 Mg2+ binding site [ion binding]; other site 1093787016617 G-X-G motif; other site 1093787016618 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1093787016619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787016620 active site 1093787016621 phosphorylation site [posttranslational modification] 1093787016622 intermolecular recognition site; other site 1093787016623 dimerization interface [polypeptide binding]; other site 1093787016624 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787016625 DNA binding site [nucleotide binding] 1093787016626 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1093787016627 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1093787016628 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1093787016629 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1093787016630 RNA binding site [nucleotide binding]; other site 1093787016631 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1093787016632 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1093787016633 CoenzymeA binding site [chemical binding]; other site 1093787016634 subunit interaction site [polypeptide binding]; other site 1093787016635 PHB binding site; other site 1093787016636 glutamate--cysteine ligase; Provisional; Region: PRK02107 1093787016637 N-acetylglutamate synthase; Validated; Region: PRK05279 1093787016638 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1093787016639 putative feedback inhibition sensing region; other site 1093787016640 putative nucleotide binding site [chemical binding]; other site 1093787016641 putative substrate binding site [chemical binding]; other site 1093787016642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787016643 Coenzyme A binding pocket [chemical binding]; other site 1093787016644 inner membrane protein; Provisional; Region: PRK10995 1093787016645 acetylornithine deacetylase; Provisional; Region: PRK05111 1093787016646 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1093787016647 metal binding site [ion binding]; metal-binding site 1093787016648 putative dimer interface [polypeptide binding]; other site 1093787016649 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1093787016650 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1093787016651 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1093787016652 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1093787016653 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1093787016654 putative active site [active] 1093787016655 putative metal binding residues [ion binding]; other site 1093787016656 signature motif; other site 1093787016657 putative triphosphate binding site [ion binding]; other site 1093787016658 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1093787016659 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1093787016660 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1093787016661 Walker A motif; other site 1093787016662 ATP binding site [chemical binding]; other site 1093787016663 Walker B motif; other site 1093787016664 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1093787016665 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1093787016666 glycine dehydrogenase; Provisional; Region: PRK12566 1093787016667 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1093787016668 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1093787016669 catalytic residue [active] 1093787016670 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1093787016671 tetramer interface [polypeptide binding]; other site 1093787016672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787016673 catalytic residue [active] 1093787016674 glycine cleavage system protein H; Provisional; Region: PRK13380 1093787016675 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1093787016676 lipoyl attachment site [posttranslational modification]; other site 1093787016677 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1093787016678 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1093787016679 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1093787016680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787016681 dimer interface [polypeptide binding]; other site 1093787016682 conserved gate region; other site 1093787016683 putative PBP binding loops; other site 1093787016684 ABC-ATPase subunit interface; other site 1093787016685 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1093787016686 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1093787016687 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1093787016688 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787016689 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1093787016690 dimerization interface [polypeptide binding]; other site 1093787016691 substrate binding pocket [chemical binding]; other site 1093787016692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787016693 putative substrate translocation pore; other site 1093787016694 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1093787016695 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714 1093787016696 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1093787016697 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; cl17557 1093787016698 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1093787016699 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 1093787016700 proline aminopeptidase P II; Provisional; Region: PRK10879 1093787016701 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1093787016702 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1093787016703 active site 1093787016704 hypothetical protein; Reviewed; Region: PRK02166 1093787016705 TIGR02449 family protein; Region: TIGR02449 1093787016706 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 1093787016707 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1093787016708 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1093787016709 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1093787016710 Uncharacterized conserved protein [Function unknown]; Region: COG2947 1093787016711 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1093787016712 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1093787016713 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1093787016714 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1093787016715 Walker A/P-loop; other site 1093787016716 ATP binding site [chemical binding]; other site 1093787016717 Q-loop/lid; other site 1093787016718 ABC transporter signature motif; other site 1093787016719 Walker B; other site 1093787016720 D-loop; other site 1093787016721 H-loop/switch region; other site 1093787016722 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1093787016723 Walker A/P-loop; other site 1093787016724 ATP binding site [chemical binding]; other site 1093787016725 Q-loop/lid; other site 1093787016726 ABC transporter signature motif; other site 1093787016727 Walker B; other site 1093787016728 D-loop; other site 1093787016729 H-loop/switch region; other site 1093787016730 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1093787016731 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1093787016732 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1093787016733 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1093787016734 HlyD family secretion protein; Region: HlyD_3; pfam13437 1093787016735 flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697 1093787016736 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1093787016737 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1093787016738 NAD(P) binding site [chemical binding]; other site 1093787016739 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1093787016740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787016741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787016742 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1093787016743 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1093787016744 catalytic loop [active] 1093787016745 iron binding site [ion binding]; other site 1093787016746 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1093787016747 FAD binding pocket [chemical binding]; other site 1093787016748 FAD binding motif [chemical binding]; other site 1093787016749 phosphate binding motif [ion binding]; other site 1093787016750 beta-alpha-beta structure motif; other site 1093787016751 NAD binding pocket [chemical binding]; other site 1093787016752 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1093787016753 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1093787016754 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1093787016755 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1093787016756 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1093787016757 RNA binding site [nucleotide binding]; other site 1093787016758 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1093787016759 multimer interface [polypeptide binding]; other site 1093787016760 Walker A motif; other site 1093787016761 ATP binding site [chemical binding]; other site 1093787016762 Walker B motif; other site 1093787016763 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1093787016764 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1093787016765 catalytic residues [active] 1093787016766 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1093787016767 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1093787016768 polyphosphate kinase; Provisional; Region: PRK05443 1093787016769 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1093787016770 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1093787016771 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1093787016772 putative domain interface [polypeptide binding]; other site 1093787016773 putative active site [active] 1093787016774 catalytic site [active] 1093787016775 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1093787016776 putative domain interface [polypeptide binding]; other site 1093787016777 putative active site [active] 1093787016778 catalytic site [active] 1093787016779 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1093787016780 dimer interface [polypeptide binding]; other site 1093787016781 active site 1093787016782 aspartate-rich active site metal binding site; other site 1093787016783 allosteric magnesium binding site [ion binding]; other site 1093787016784 Schiff base residues; other site 1093787016785 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1093787016786 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1093787016787 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1093787016788 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1093787016789 conserved cys residue [active] 1093787016790 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1093787016791 CoenzymeA binding site [chemical binding]; other site 1093787016792 subunit interaction site [polypeptide binding]; other site 1093787016793 PHB binding site; other site 1093787016794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 1093787016795 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1093787016796 Cytochrome c; Region: Cytochrom_C; pfam00034 1093787016797 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1093787016798 LysE type translocator; Region: LysE; cl00565 1093787016799 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1093787016800 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1093787016801 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1093787016802 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1093787016803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787016804 Walker A/P-loop; other site 1093787016805 ATP binding site [chemical binding]; other site 1093787016806 Q-loop/lid; other site 1093787016807 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1093787016808 ABC transporter; Region: ABC_tran_2; pfam12848 1093787016809 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1093787016810 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 1093787016811 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1093787016812 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1093787016813 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1093787016814 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 1093787016815 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1093787016816 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 1093787016817 HemY protein N-terminus; Region: HemY_N; pfam07219 1093787016818 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1093787016819 binding surface 1093787016820 TPR motif; other site 1093787016821 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1093787016822 uroporphyrinogen-III synthase; Validated; Region: PRK05752 1093787016823 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1093787016824 active site 1093787016825 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1093787016826 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1093787016827 domain interfaces; other site 1093787016828 active site 1093787016829 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1093787016830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787016831 active site 1093787016832 phosphorylation site [posttranslational modification] 1093787016833 intermolecular recognition site; other site 1093787016834 dimerization interface [polypeptide binding]; other site 1093787016835 LytTr DNA-binding domain; Region: LytTR; pfam04397 1093787016836 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1093787016837 Histidine kinase; Region: His_kinase; pfam06580 1093787016838 argininosuccinate lyase; Provisional; Region: PRK00855 1093787016839 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1093787016840 active sites [active] 1093787016841 tetramer interface [polypeptide binding]; other site 1093787016842 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1093787016843 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1093787016844 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1093787016845 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1093787016846 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1093787016847 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1093787016848 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 1093787016849 Cl binding site [ion binding]; other site 1093787016850 oligomer interface [polypeptide binding]; other site 1093787016851 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 1093787016852 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787016853 substrate binding pocket [chemical binding]; other site 1093787016854 membrane-bound complex binding site; other site 1093787016855 hinge residues; other site 1093787016856 TIGR02647 family protein; Region: DNA 1093787016857 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 1093787016858 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1093787016859 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1093787016860 Uncharacterized conserved protein [Function unknown]; Region: COG4278 1093787016861 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1093787016862 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1093787016863 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1093787016864 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1093787016865 putative iron binding site [ion binding]; other site 1093787016866 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 1093787016867 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1093787016868 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1093787016869 active site 1093787016870 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1093787016871 substrate binding site [chemical binding]; other site 1093787016872 catalytic residues [active] 1093787016873 dimer interface [polypeptide binding]; other site 1093787016874 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1093787016875 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1093787016876 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1093787016877 Protein of unknown function, DUF484; Region: DUF484; pfam04340 1093787016878 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1093787016879 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1093787016880 active site 1093787016881 DNA binding site [nucleotide binding] 1093787016882 Int/Topo IB signature motif; other site 1093787016883 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1093787016884 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1093787016885 motif II; other site 1093787016886 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1093787016887 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787016888 DNA-binding site [nucleotide binding]; DNA binding site 1093787016889 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1093787016890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787016891 homodimer interface [polypeptide binding]; other site 1093787016892 catalytic residue [active] 1093787016893 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1093787016894 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1093787016895 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1093787016896 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1093787016897 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1093787016898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1093787016899 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1093787016900 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1093787016901 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1093787016902 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1093787016903 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1093787016904 active site 1093787016905 dimerization interface [polypeptide binding]; other site 1093787016906 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1093787016907 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1093787016908 active site 1093787016909 Transposase domain (DUF772); Region: DUF772; pfam05598 1093787016910 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 1093787016911 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1093787016912 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1093787016913 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1093787016914 MarR family; Region: MarR; pfam01047 1093787016915 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1093787016916 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1093787016917 Coenzyme A binding pocket [chemical binding]; other site 1093787016918 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1093787016919 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 1093787016920 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 1093787016921 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1093787016922 P loop; other site 1093787016923 Nucleotide binding site [chemical binding]; other site 1093787016924 DTAP/Switch II; other site 1093787016925 Switch I; other site 1093787016926 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1093787016927 P loop; other site 1093787016928 Nucleotide binding site [chemical binding]; other site 1093787016929 DTAP/Switch II; other site 1093787016930 Switch I; other site 1093787016931 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1093787016932 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1093787016933 active site 1093787016934 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1093787016935 dimerization interface [polypeptide binding]; other site 1093787016936 putative DNA binding site [nucleotide binding]; other site 1093787016937 putative Zn2+ binding site [ion binding]; other site 1093787016938 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1093787016939 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1093787016940 active site 1093787016941 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1093787016942 arsenical-resistance protein; Region: acr3; TIGR00832 1093787016943 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 1093787016944 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1093787016945 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1093787016946 active site 1093787016947 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 1093787016948 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1093787016949 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1093787016950 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1093787016951 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787016952 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1093787016953 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1093787016954 AAA domain; Region: AAA_23; pfam13476 1093787016955 AAA domain; Region: AAA_21; pfam13304 1093787016956 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787016957 ABC transporter signature motif; other site 1093787016958 Walker B; other site 1093787016959 D-loop; other site 1093787016960 H-loop/switch region; other site 1093787016961 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1093787016962 active site 1093787016963 metal binding site [ion binding]; metal-binding site 1093787016964 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1093787016965 Family description; Region: UvrD_C_2; pfam13538 1093787016966 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1093787016967 DNA binding site [nucleotide binding] 1093787016968 active site 1093787016969 Int/Topo IB signature motif; other site 1093787016970 catalytic residues [active] 1093787016971 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1093787016972 active site 1093787016973 catalytic residues [active] 1093787016974 DNA binding site [nucleotide binding] 1093787016975 Int/Topo IB signature motif; other site 1093787016976 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1093787016977 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1093787016978 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1093787016979 BCCT family transporter; Region: BCCT; cl00569 1093787016980 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1093787016981 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1093787016982 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787016983 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1093787016984 dimerization interface [polypeptide binding]; other site 1093787016985 substrate binding pocket [chemical binding]; other site 1093787016986 multidrug efflux protein NorA; Provisional; Region: PRK00187 1093787016987 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1093787016988 cation binding site [ion binding]; other site 1093787016989 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787016990 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787016991 metal binding site [ion binding]; metal-binding site 1093787016992 active site 1093787016993 I-site; other site 1093787016994 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1093787016995 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 1093787016996 Part of AAA domain; Region: AAA_19; pfam13245 1093787016997 Family description; Region: UvrD_C_2; pfam13538 1093787016998 pyruvate dehydrogenase; Provisional; Region: PRK09124 1093787016999 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1093787017000 PYR/PP interface [polypeptide binding]; other site 1093787017001 dimer interface [polypeptide binding]; other site 1093787017002 tetramer interface [polypeptide binding]; other site 1093787017003 TPP binding site [chemical binding]; other site 1093787017004 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1093787017005 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1093787017006 TPP-binding site [chemical binding]; other site 1093787017007 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1093787017008 active site 1093787017009 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1093787017010 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1093787017011 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 1093787017012 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1093787017013 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1093787017014 non-specific DNA binding site [nucleotide binding]; other site 1093787017015 salt bridge; other site 1093787017016 sequence-specific DNA binding site [nucleotide binding]; other site 1093787017017 Cupin domain; Region: Cupin_2; pfam07883 1093787017018 alanine racemase; Reviewed; Region: dadX; PRK03646 1093787017019 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1093787017020 active site 1093787017021 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1093787017022 substrate binding site [chemical binding]; other site 1093787017023 catalytic residues [active] 1093787017024 dimer interface [polypeptide binding]; other site 1093787017025 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1093787017026 homotrimer interaction site [polypeptide binding]; other site 1093787017027 putative active site [active] 1093787017028 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1093787017029 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1093787017030 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 1093787017031 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1093787017032 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 1093787017033 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1093787017034 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1093787017035 putative DNA binding site [nucleotide binding]; other site 1093787017036 putative Zn2+ binding site [ion binding]; other site 1093787017037 AsnC family; Region: AsnC_trans_reg; pfam01037 1093787017038 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1093787017039 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1093787017040 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1093787017041 PLD-like domain; Region: PLDc_2; pfam13091 1093787017042 putative active site [active] 1093787017043 catalytic site [active] 1093787017044 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1093787017045 PLD-like domain; Region: PLDc_2; pfam13091 1093787017046 putative active site [active] 1093787017047 catalytic site [active] 1093787017048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787017049 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1093787017050 putative substrate translocation pore; other site 1093787017051 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1093787017052 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1093787017053 NAD(P) binding site [chemical binding]; other site 1093787017054 catalytic residues [active] 1093787017055 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1093787017056 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1093787017057 inhibitor-cofactor binding pocket; inhibition site 1093787017058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787017059 catalytic residue [active] 1093787017060 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1093787017061 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1093787017062 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1093787017063 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1093787017064 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1093787017065 peptide binding site [polypeptide binding]; other site 1093787017066 hypothetical protein; Reviewed; Region: PRK00024 1093787017067 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1093787017068 MPN+ (JAMM) motif; other site 1093787017069 Zinc-binding site [ion binding]; other site 1093787017070 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1093787017071 Flavoprotein; Region: Flavoprotein; pfam02441 1093787017072 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1093787017073 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1093787017074 trimer interface [polypeptide binding]; other site 1093787017075 active site 1093787017076 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1093787017077 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1093787017078 active site 1093787017079 substrate binding site [chemical binding]; other site 1093787017080 metal binding site [ion binding]; metal-binding site 1093787017081 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1093787017082 feedback inhibition sensing region; other site 1093787017083 homohexameric interface [polypeptide binding]; other site 1093787017084 nucleotide binding site [chemical binding]; other site 1093787017085 N-acetyl-L-glutamate binding site [chemical binding]; other site 1093787017086 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1093787017087 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1093787017088 SurA N-terminal domain; Region: SurA_N; pfam09312 1093787017089 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787017090 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 1093787017091 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1093787017092 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 3; Region: PLPDE_III_DSD_D-TA_like_3; cd06814 1093787017093 dimer interface [polypeptide binding]; other site 1093787017094 active site 1093787017095 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1093787017096 substrate binding site [chemical binding]; other site 1093787017097 catalytic residue [active] 1093787017098 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1093787017099 FAD binding domain; Region: FAD_binding_4; pfam01565 1093787017100 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1093787017101 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 1093787017102 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1093787017103 active site 1093787017104 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1093787017105 active site 1093787017106 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1093787017107 putative active site [active] 1093787017108 putative catalytic site [active] 1093787017109 putative DNA binding site [nucleotide binding]; other site 1093787017110 putative phosphate binding site [ion binding]; other site 1093787017111 metal binding site A [ion binding]; metal-binding site 1093787017112 putative AP binding site [nucleotide binding]; other site 1093787017113 putative metal binding site B [ion binding]; other site 1093787017114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 1093787017115 ribonuclease PH; Reviewed; Region: rph; PRK00173 1093787017116 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1093787017117 hexamer interface [polypeptide binding]; other site 1093787017118 active site 1093787017119 hypothetical protein; Provisional; Region: PRK11820 1093787017120 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1093787017121 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1093787017122 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1093787017123 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1093787017124 catalytic site [active] 1093787017125 G-X2-G-X-G-K; other site 1093787017126 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1093787017127 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1093787017128 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1093787017129 Zn2+ binding site [ion binding]; other site 1093787017130 Mg2+ binding site [ion binding]; other site 1093787017131 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1093787017132 synthetase active site [active] 1093787017133 NTP binding site [chemical binding]; other site 1093787017134 metal binding site [ion binding]; metal-binding site 1093787017135 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1093787017136 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1093787017137 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1093787017138 homotrimer interaction site [polypeptide binding]; other site 1093787017139 putative active site [active] 1093787017140 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1093787017141 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1093787017142 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1093787017143 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787017144 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1093787017145 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1093787017146 putative NAD(P) binding site [chemical binding]; other site 1093787017147 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1093787017148 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787017149 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1093787017150 dimerization interface [polypeptide binding]; other site 1093787017151 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1093787017152 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1093787017153 ssDNA binding site; other site 1093787017154 generic binding surface II; other site 1093787017155 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1093787017156 ATP binding site [chemical binding]; other site 1093787017157 putative Mg++ binding site [ion binding]; other site 1093787017158 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1093787017159 nucleotide binding region [chemical binding]; other site 1093787017160 ATP-binding site [chemical binding]; other site 1093787017161 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1093787017162 putative deacylase active site [active] 1093787017163 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1093787017164 Iron/zinc purple acid phosphatase-like protein C; Region: Metallophos_C; pfam14008 1093787017165 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1093787017166 IHF dimer interface [polypeptide binding]; other site 1093787017167 IHF - DNA interface [nucleotide binding]; other site 1093787017168 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1093787017169 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1093787017170 Rubredoxin [Energy production and conversion]; Region: COG1773 1093787017171 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1093787017172 iron binding site [ion binding]; other site 1093787017173 Rubredoxin [Energy production and conversion]; Region: COG1773 1093787017174 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1093787017175 iron binding site [ion binding]; other site 1093787017176 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 1093787017177 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1093787017178 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1093787017179 Cysteine-rich domain; Region: CCG; pfam02754 1093787017180 Cysteine-rich domain; Region: CCG; pfam02754 1093787017181 FAD binding domain; Region: FAD_binding_4; pfam01565 1093787017182 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1093787017183 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1093787017184 FAD binding domain; Region: FAD_binding_4; pfam01565 1093787017185 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 1093787017186 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787017187 DNA-binding site [nucleotide binding]; DNA binding site 1093787017188 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1093787017189 Chorismate lyase; Region: Chor_lyase; pfam04345 1093787017190 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1093787017191 UbiA prenyltransferase family; Region: UbiA; pfam01040 1093787017192 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1093787017193 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1093787017194 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1093787017195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787017196 active site 1093787017197 phosphorylation site [posttranslational modification] 1093787017198 intermolecular recognition site; other site 1093787017199 dimerization interface [polypeptide binding]; other site 1093787017200 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1093787017201 DNA binding site [nucleotide binding] 1093787017202 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1093787017203 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1093787017204 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787017205 putative active site [active] 1093787017206 heme pocket [chemical binding]; other site 1093787017207 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787017208 dimer interface [polypeptide binding]; other site 1093787017209 phosphorylation site [posttranslational modification] 1093787017210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787017211 ATP binding site [chemical binding]; other site 1093787017212 Mg2+ binding site [ion binding]; other site 1093787017213 G-X-G motif; other site 1093787017214 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1093787017215 Domain of unknown function DUF21; Region: DUF21; pfam01595 1093787017216 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1093787017217 Transporter associated domain; Region: CorC_HlyC; smart01091 1093787017218 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1093787017219 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1093787017220 Peptidase family M23; Region: Peptidase_M23; pfam01551 1093787017221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787017222 Response regulator receiver domain; Region: Response_reg; pfam00072 1093787017223 active site 1093787017224 phosphorylation site [posttranslational modification] 1093787017225 intermolecular recognition site; other site 1093787017226 dimerization interface [polypeptide binding]; other site 1093787017227 transcriptional regulator PhoU; Provisional; Region: PRK11115 1093787017228 PhoU domain; Region: PhoU; pfam01895 1093787017229 PhoU domain; Region: PhoU; pfam01895 1093787017230 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 1093787017231 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1093787017232 Walker A/P-loop; other site 1093787017233 ATP binding site [chemical binding]; other site 1093787017234 Q-loop/lid; other site 1093787017235 ABC transporter signature motif; other site 1093787017236 Walker B; other site 1093787017237 D-loop; other site 1093787017238 H-loop/switch region; other site 1093787017239 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 1093787017240 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1093787017241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787017242 dimer interface [polypeptide binding]; other site 1093787017243 conserved gate region; other site 1093787017244 putative PBP binding loops; other site 1093787017245 ABC-ATPase subunit interface; other site 1093787017246 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 1093787017247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787017248 ABC-ATPase subunit interface; other site 1093787017249 PBP superfamily domain; Region: PBP_like_2; cl17296 1093787017250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787017251 metabolite-proton symporter; Region: 2A0106; TIGR00883 1093787017252 putative substrate translocation pore; other site 1093787017253 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1093787017254 choline dehydrogenase; Validated; Region: PRK02106 1093787017255 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1093787017256 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1093787017257 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1093787017258 tetrameric interface [polypeptide binding]; other site 1093787017259 NAD binding site [chemical binding]; other site 1093787017260 catalytic residues [active] 1093787017261 transcriptional regulator BetI; Validated; Region: PRK00767 1093787017262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1093787017263 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1093787017264 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1093787017265 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 1093787017266 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1093787017267 Walker A/P-loop; other site 1093787017268 ATP binding site [chemical binding]; other site 1093787017269 Q-loop/lid; other site 1093787017270 ABC transporter signature motif; other site 1093787017271 Walker B; other site 1093787017272 D-loop; other site 1093787017273 H-loop/switch region; other site 1093787017274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787017275 dimer interface [polypeptide binding]; other site 1093787017276 conserved gate region; other site 1093787017277 putative PBP binding loops; other site 1093787017278 ABC-ATPase subunit interface; other site 1093787017279 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1093787017280 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1093787017281 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1093787017282 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1093787017283 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1093787017284 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1093787017285 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1093787017286 conserved cys residue [active] 1093787017287 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787017288 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1093787017289 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787017290 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1093787017291 putative dimerization interface [polypeptide binding]; other site 1093787017292 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 1093787017293 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1093787017294 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1093787017295 active site 1093787017296 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 1093787017297 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1093787017298 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1093787017299 Uncharacterized conserved protein [Function unknown]; Region: COG3246 1093787017300 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1093787017301 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1093787017302 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1093787017303 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1093787017304 conserved cys residue [active] 1093787017305 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1093787017306 acetylornithine deacetylase; Provisional; Region: PRK07522 1093787017307 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1093787017308 metal binding site [ion binding]; metal-binding site 1093787017309 putative dimer interface [polypeptide binding]; other site 1093787017310 Uncharacterized conserved protein [Function unknown]; Region: COG3342 1093787017311 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1093787017312 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1093787017313 homotrimer interaction site [polypeptide binding]; other site 1093787017314 putative active site [active] 1093787017315 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1093787017316 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1093787017317 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1093787017318 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 1093787017319 putative active site [active] 1093787017320 catalytic site [active] 1093787017321 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 1093787017322 putative active site [active] 1093787017323 catalytic site [active] 1093787017324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 1093787017325 SnoaL-like domain; Region: SnoaL_2; pfam12680 1093787017326 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1093787017327 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 1093787017328 active site 1093787017329 V4R domain; Region: V4R; cl15268 1093787017330 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1093787017331 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 1093787017332 putative active site [active] 1093787017333 putative FMN binding site [chemical binding]; other site 1093787017334 putative substrate binding site [chemical binding]; other site 1093787017335 putative catalytic residue [active] 1093787017336 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1093787017337 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 1093787017338 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1093787017339 Cysteine-rich domain; Region: CCG; pfam02754 1093787017340 Cysteine-rich domain; Region: CCG; pfam02754 1093787017341 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1093787017342 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1093787017343 Ligand Binding Site [chemical binding]; other site 1093787017344 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1093787017345 Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086 1093787017346 Ligand Binding Site [chemical binding]; other site 1093787017347 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1093787017348 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 1093787017349 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1093787017350 non-specific DNA binding site [nucleotide binding]; other site 1093787017351 salt bridge; other site 1093787017352 sequence-specific DNA binding site [nucleotide binding]; other site 1093787017353 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 1093787017354 Cell division protein ZapA; Region: ZapA; pfam05164 1093787017355 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1093787017356 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1093787017357 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1093787017358 [2Fe-2S] cluster binding site [ion binding]; other site 1093787017359 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1093787017360 putative alpha subunit interface [polypeptide binding]; other site 1093787017361 putative active site [active] 1093787017362 putative substrate binding site [chemical binding]; other site 1093787017363 Fe binding site [ion binding]; other site 1093787017364 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1093787017365 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1093787017366 FAD binding pocket [chemical binding]; other site 1093787017367 FAD binding motif [chemical binding]; other site 1093787017368 phosphate binding motif [ion binding]; other site 1093787017369 beta-alpha-beta structure motif; other site 1093787017370 NAD binding pocket [chemical binding]; other site 1093787017371 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1093787017372 catalytic loop [active] 1093787017373 iron binding site [ion binding]; other site 1093787017374 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1093787017375 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1093787017376 tetramer interface [polypeptide binding]; other site 1093787017377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787017378 catalytic residue [active] 1093787017379 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1093787017380 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1093787017381 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 1093787017382 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1093787017383 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1093787017384 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1093787017385 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 1093787017386 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 1093787017387 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1093787017388 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1093787017389 putative active site [active] 1093787017390 putative substrate binding site [chemical binding]; other site 1093787017391 putative cosubstrate binding site; other site 1093787017392 catalytic site [active] 1093787017393 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1093787017394 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1093787017395 NAD binding site [chemical binding]; other site 1093787017396 catalytic Zn binding site [ion binding]; other site 1093787017397 structural Zn binding site [ion binding]; other site 1093787017398 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1093787017399 active site 1093787017400 phosphate binding residues; other site 1093787017401 catalytic residues [active] 1093787017402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3495 1093787017403 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1093787017404 ATP-grasp domain; Region: ATP-grasp; pfam02222 1093787017405 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1093787017406 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1093787017407 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1093787017408 NAD binding site [chemical binding]; other site 1093787017409 substrate binding site [chemical binding]; other site 1093787017410 catalytic Zn binding site [ion binding]; other site 1093787017411 tetramer interface [polypeptide binding]; other site 1093787017412 structural Zn binding site [ion binding]; other site 1093787017413 cell density-dependent motility repressor; Provisional; Region: PRK10082 1093787017414 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787017415 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1093787017416 dimerization interface [polypeptide binding]; other site 1093787017417 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1093787017418 Aspartase; Region: Aspartase; cd01357 1093787017419 active sites [active] 1093787017420 tetramer interface [polypeptide binding]; other site 1093787017421 Predicted transporter component [General function prediction only]; Region: COG2391 1093787017422 Sulphur transport; Region: Sulf_transp; pfam04143 1093787017423 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1093787017424 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787017425 DNA-binding site [nucleotide binding]; DNA binding site 1093787017426 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1093787017427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787017428 homodimer interface [polypeptide binding]; other site 1093787017429 catalytic residue [active] 1093787017430 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1093787017431 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1093787017432 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1093787017433 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1093787017434 aromatic amino acid transport protein; Region: araaP; TIGR00837 1093787017435 pyruvate carboxylase subunit B; Validated; Region: PRK09282 1093787017436 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1093787017437 active site 1093787017438 catalytic residues [active] 1093787017439 metal binding site [ion binding]; metal-binding site 1093787017440 homodimer binding site [polypeptide binding]; other site 1093787017441 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1093787017442 carboxyltransferase (CT) interaction site; other site 1093787017443 biotinylation site [posttranslational modification]; other site 1093787017444 pyruvate carboxylase subunit A; Validated; Region: PRK07178 1093787017445 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1093787017446 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1093787017447 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1093787017448 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1093787017449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1093787017450 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 1093787017451 putative dimerization interface [polypeptide binding]; other site 1093787017452 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1093787017453 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1093787017454 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1093787017455 putative active site [active] 1093787017456 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1093787017457 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1093787017458 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1093787017459 putative protease; Provisional; Region: PRK15452 1093787017460 Peptidase family U32; Region: Peptidase_U32; pfam01136 1093787017461 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 1093787017462 PAS fold; Region: PAS_3; pfam08447 1093787017463 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787017464 heme pocket [chemical binding]; other site 1093787017465 putative active site [active] 1093787017466 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787017467 PAS domain; Region: PAS_9; pfam13426 1093787017468 putative active site [active] 1093787017469 heme pocket [chemical binding]; other site 1093787017470 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787017471 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787017472 metal binding site [ion binding]; metal-binding site 1093787017473 active site 1093787017474 I-site; other site 1093787017475 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1093787017476 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1093787017477 Part of AAA domain; Region: AAA_19; pfam13245 1093787017478 Family description; Region: UvrD_C_2; pfam13538 1093787017479 Predicted membrane protein [Function unknown]; Region: COG2510 1093787017480 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1093787017481 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1093787017482 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1093787017483 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1093787017484 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1093787017485 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 1093787017486 putative ADP-binding pocket [chemical binding]; other site 1093787017487 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1093787017488 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1093787017489 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1093787017490 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1093787017491 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1093787017492 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1093787017493 Walker A/P-loop; other site 1093787017494 ATP binding site [chemical binding]; other site 1093787017495 Q-loop/lid; other site 1093787017496 ABC transporter signature motif; other site 1093787017497 Walker B; other site 1093787017498 D-loop; other site 1093787017499 H-loop/switch region; other site 1093787017500 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1093787017501 putative carbohydrate binding site [chemical binding]; other site 1093787017502 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1093787017503 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1093787017504 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1093787017505 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1093787017506 Substrate binding site; other site 1093787017507 Cupin domain; Region: Cupin_2; cl17218 1093787017508 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1093787017509 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1093787017510 NADP-binding site; other site 1093787017511 homotetramer interface [polypeptide binding]; other site 1093787017512 substrate binding site [chemical binding]; other site 1093787017513 homodimer interface [polypeptide binding]; other site 1093787017514 active site 1093787017515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787017516 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1093787017517 NAD(P) binding site [chemical binding]; other site 1093787017518 active site 1093787017519 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1093787017520 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1093787017521 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1093787017522 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1093787017523 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 1093787017524 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1093787017525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787017526 S-adenosylmethionine binding site [chemical binding]; other site 1093787017527 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1093787017528 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1093787017529 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1093787017530 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1093787017531 conserverd hypothetical protein; Region: TIGR02448 1093787017532 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1093787017533 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1093787017534 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1093787017535 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1093787017536 Predicted permeases [General function prediction only]; Region: COG0679 1093787017537 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1093787017538 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1093787017539 Citrate transporter; Region: CitMHS; pfam03600 1093787017540 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1093787017541 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 1093787017542 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1093787017543 hypothetical protein; Reviewed; Region: PRK09588 1093787017544 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 1093787017545 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1093787017546 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1093787017547 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1093787017548 PhoU domain; Region: PhoU; pfam01895 1093787017549 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1093787017550 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1093787017551 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1093787017552 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1093787017553 citrate-proton symporter; Provisional; Region: PRK15075 1093787017554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787017555 putative substrate translocation pore; other site 1093787017556 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 1093787017557 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1093787017558 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1093787017559 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1093787017560 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1093787017561 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 1093787017562 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1093787017563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787017564 active site 1093787017565 phosphorylation site [posttranslational modification] 1093787017566 intermolecular recognition site; other site 1093787017567 dimerization interface [polypeptide binding]; other site 1093787017568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787017569 Walker A motif; other site 1093787017570 ATP binding site [chemical binding]; other site 1093787017571 Walker B motif; other site 1093787017572 arginine finger; other site 1093787017573 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1093787017574 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1093787017575 dimerization interface [polypeptide binding]; other site 1093787017576 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1093787017577 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1093787017578 putative active site [active] 1093787017579 heme pocket [chemical binding]; other site 1093787017580 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787017581 dimer interface [polypeptide binding]; other site 1093787017582 phosphorylation site [posttranslational modification] 1093787017583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787017584 ATP binding site [chemical binding]; other site 1093787017585 Mg2+ binding site [ion binding]; other site 1093787017586 G-X-G motif; other site 1093787017587 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1093787017588 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1093787017589 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1093787017590 amidase catalytic site [active] 1093787017591 Zn binding residues [ion binding]; other site 1093787017592 substrate binding site [chemical binding]; other site 1093787017593 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1093787017594 MarC family integral membrane protein; Region: MarC; cl00919 1093787017595 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1093787017596 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1093787017597 metal binding site [ion binding]; metal-binding site 1093787017598 active site 1093787017599 I-site; other site 1093787017600 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1093787017601 putative catalytic site [active] 1093787017602 putative metal binding site [ion binding]; other site 1093787017603 putative phosphate binding site [ion binding]; other site 1093787017604 putative catalytic site [active] 1093787017605 putative phosphate binding site [ion binding]; other site 1093787017606 putative metal binding site [ion binding]; other site 1093787017607 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1093787017608 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1093787017609 catalytic residues [active] 1093787017610 hinge region; other site 1093787017611 alpha helical domain; other site 1093787017612 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1093787017613 Cytochrome c; Region: Cytochrom_C; cl11414 1093787017614 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 1093787017615 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1093787017616 G1 box; other site 1093787017617 GTP/Mg2+ binding site [chemical binding]; other site 1093787017618 Switch I region; other site 1093787017619 G2 box; other site 1093787017620 G3 box; other site 1093787017621 Switch II region; other site 1093787017622 G4 box; other site 1093787017623 G5 box; other site 1093787017624 DNA polymerase I; Provisional; Region: PRK05755 1093787017625 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1093787017626 active site 1093787017627 metal binding site 1 [ion binding]; metal-binding site 1093787017628 putative 5' ssDNA interaction site; other site 1093787017629 metal binding site 3; metal-binding site 1093787017630 metal binding site 2 [ion binding]; metal-binding site 1093787017631 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1093787017632 putative DNA binding site [nucleotide binding]; other site 1093787017633 putative metal binding site [ion binding]; other site 1093787017634 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1093787017635 active site 1093787017636 catalytic site [active] 1093787017637 substrate binding site [chemical binding]; other site 1093787017638 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1093787017639 active site 1093787017640 DNA binding site [nucleotide binding] 1093787017641 catalytic site [active] 1093787017642 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1093787017643 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1093787017644 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1093787017645 putative active site [active] 1093787017646 putative substrate binding site [chemical binding]; other site 1093787017647 ATP binding site [chemical binding]; other site 1093787017648 Ribonucleotide reductase, alpha subunit [Nucleotide transport and metabolism]; Region: NrdA; COG0209 1093787017649 TSCPD domain; Region: TSCPD; pfam12637 1093787017650 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1093787017651 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1093787017652 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1093787017653 active site 1093787017654 dimer interface [polypeptide binding]; other site 1093787017655 effector binding site; other site 1093787017656 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1093787017657 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 1093787017658 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1093787017659 metal binding site [ion binding]; metal-binding site 1093787017660 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1093787017661 Predicted transcriptional regulators [Transcription]; Region: COG1695 1093787017662 metal binding site 2 [ion binding]; metal-binding site 1093787017663 putative DNA binding helix; other site 1093787017664 metal binding site 1 [ion binding]; metal-binding site 1093787017665 dimer interface [polypeptide binding]; other site 1093787017666 structural Zn2+ binding site [ion binding]; other site 1093787017667 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1093787017668 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1093787017669 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1093787017670 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1093787017671 dimer interface [polypeptide binding]; other site 1093787017672 putative PBP binding regions; other site 1093787017673 ABC-ATPase subunit interface; other site 1093787017674 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1093787017675 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1093787017676 Walker A/P-loop; other site 1093787017677 ATP binding site [chemical binding]; other site 1093787017678 Q-loop/lid; other site 1093787017679 ABC transporter signature motif; other site 1093787017680 Walker B; other site 1093787017681 D-loop; other site 1093787017682 H-loop/switch region; other site 1093787017683 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1093787017684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1093787017685 dimer interface [polypeptide binding]; other site 1093787017686 conserved gate region; other site 1093787017687 ABC-ATPase subunit interface; other site 1093787017688 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1093787017689 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1093787017690 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1093787017691 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1093787017692 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1093787017693 putative active site [active] 1093787017694 Isochorismatase family; Region: Isochorismatase; pfam00857 1093787017695 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1093787017696 catalytic triad [active] 1093787017697 conserved cis-peptide bond; other site 1093787017698 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1093787017699 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1093787017700 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 1093787017701 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1093787017702 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1093787017703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1093787017704 active site 1093787017705 phosphorylation site [posttranslational modification] 1093787017706 intermolecular recognition site; other site 1093787017707 dimerization interface [polypeptide binding]; other site 1093787017708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1093787017709 Walker A motif; other site 1093787017710 ATP binding site [chemical binding]; other site 1093787017711 Walker B motif; other site 1093787017712 arginine finger; other site 1093787017713 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1093787017714 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1093787017715 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1093787017716 dimer interface [polypeptide binding]; other site 1093787017717 phosphorylation site [posttranslational modification] 1093787017718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1093787017719 ATP binding site [chemical binding]; other site 1093787017720 Mg2+ binding site [ion binding]; other site 1093787017721 G-X-G motif; other site 1093787017722 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1093787017723 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1093787017724 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1093787017725 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 1093787017726 pyridoxamine kinase; Validated; Region: PRK05756 1093787017727 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1093787017728 pyridoxal binding site [chemical binding]; other site 1093787017729 dimer interface [polypeptide binding]; other site 1093787017730 ATP binding site [chemical binding]; other site 1093787017731 Predicted membrane protein [Function unknown]; Region: COG1238 1093787017732 putative cation:proton antiport protein; Provisional; Region: PRK10669 1093787017733 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1093787017734 TrkA-N domain; Region: TrkA_N; pfam02254 1093787017735 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1093787017736 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1093787017737 classical (c) SDRs; Region: SDR_c; cd05233 1093787017738 NAD(P) binding site [chemical binding]; other site 1093787017739 active site 1093787017740 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1093787017741 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1093787017742 aminotransferase; Validated; Region: PRK07046 1093787017743 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1093787017744 inhibitor-cofactor binding pocket; inhibition site 1093787017745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1093787017746 catalytic residue [active] 1093787017747 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1093787017748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1093787017749 NAD(P) binding site [chemical binding]; other site 1093787017750 active site 1093787017751 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1093787017752 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1093787017753 DNA-binding site [nucleotide binding]; DNA binding site 1093787017754 FCD domain; Region: FCD; pfam07729 1093787017755 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1093787017756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 1093787017757 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1093787017758 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1093787017759 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1093787017760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787017761 putative substrate translocation pore; other site 1093787017762 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1093787017763 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1093787017764 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1093787017765 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1093787017766 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 1093787017767 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 1093787017768 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1093787017769 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1093787017770 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1093787017771 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1093787017772 AMIN domain; Region: AMIN; pfam11741 1093787017773 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1093787017774 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1093787017775 active site 1093787017776 metal binding site [ion binding]; metal-binding site 1093787017777 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1093787017778 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1093787017779 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 1093787017780 trimer interface [polypeptide binding]; other site 1093787017781 active site 1093787017782 dihydroorotase; Reviewed; Region: PRK09236 1093787017783 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1093787017784 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 1093787017785 active site 1093787017786 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1093787017787 Beta-lactamase; Region: Beta-lactamase; pfam00144 1093787017788 Uncharacterized conserved protein [Function unknown]; Region: COG4729 1093787017789 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 1093787017790 DctM-like transporters; Region: DctM; pfam06808 1093787017791 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1093787017792 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1093787017793 substrate binding pocket [chemical binding]; other site 1093787017794 membrane-bound complex binding site; other site 1093787017795 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1093787017796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1093787017797 S-adenosylmethionine binding site [chemical binding]; other site 1093787017798 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1093787017799 Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; Region: HAD-SF-IB; TIGR01488 1093787017800 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1093787017801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1093787017802 putative substrate translocation pore; other site 1093787017803 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1093787017804 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1093787017805 glutaminase active site [active] 1093787017806 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1093787017807 dimer interface [polypeptide binding]; other site 1093787017808 active site 1093787017809 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1093787017810 dimer interface [polypeptide binding]; other site 1093787017811 active site 1093787017812 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1093787017813 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1093787017814 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1093787017815 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1093787017816 Peptidase family M23; Region: Peptidase_M23; pfam01551 1093787017817 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 1093787017818 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1093787017819 Substrate binding site; other site 1093787017820 Mg++ binding site; other site 1093787017821 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1093787017822 active site 1093787017823 substrate binding site [chemical binding]; other site 1093787017824 CoA binding site [chemical binding]; other site 1093787017825 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1093787017826 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1093787017827 gamma subunit interface [polypeptide binding]; other site 1093787017828 epsilon subunit interface [polypeptide binding]; other site 1093787017829 LBP interface [polypeptide binding]; other site 1093787017830 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1093787017831 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1093787017832 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1093787017833 alpha subunit interaction interface [polypeptide binding]; other site 1093787017834 Walker A motif; other site 1093787017835 ATP binding site [chemical binding]; other site 1093787017836 Walker B motif; other site 1093787017837 inhibitor binding site; inhibition site 1093787017838 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1093787017839 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1093787017840 core domain interface [polypeptide binding]; other site 1093787017841 delta subunit interface [polypeptide binding]; other site 1093787017842 epsilon subunit interface [polypeptide binding]; other site 1093787017843 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1093787017844 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1093787017845 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1093787017846 beta subunit interaction interface [polypeptide binding]; other site 1093787017847 Walker A motif; other site 1093787017848 ATP binding site [chemical binding]; other site 1093787017849 Walker B motif; other site 1093787017850 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1093787017851 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1093787017852 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1093787017853 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1093787017854 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1093787017855 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1093787017856 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1093787017857 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1093787017858 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 1093787017859 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1093787017860 ParB-like nuclease domain; Region: ParBc; pfam02195 1093787017861 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1093787017862 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1093787017863 P-loop; other site 1093787017864 Magnesium ion binding site [ion binding]; other site 1093787017865 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1093787017866 Magnesium ion binding site [ion binding]; other site 1093787017867 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1093787017868 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1093787017869 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1093787017870 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1093787017871 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1093787017872 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1093787017873 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1093787017874 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1093787017875 G1 box; other site 1093787017876 GTP/Mg2+ binding site [chemical binding]; other site 1093787017877 Switch I region; other site 1093787017878 G2 box; other site 1093787017879 Switch II region; other site 1093787017880 G3 box; other site 1093787017881 G4 box; other site 1093787017882 G5 box; other site 1093787017883 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1093787017884 membrane protein insertase; Provisional; Region: PRK01318 1093787017885 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1093787017886 ribonuclease P; Reviewed; Region: rnpA; PRK00396 1093787017887 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399