-- dump date 20140620_003839 -- class Genbank::misc_feature -- table misc_feature_note -- id note 941193000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 941193000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193000003 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 941193000004 Walker A motif; other site 941193000005 ATP binding site [chemical binding]; other site 941193000006 Walker B motif; other site 941193000007 arginine finger; other site 941193000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 941193000009 DnaA box-binding interface [nucleotide binding]; other site 941193000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 941193000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 941193000012 putative DNA binding surface [nucleotide binding]; other site 941193000013 dimer interface [polypeptide binding]; other site 941193000014 beta-clamp/clamp loader binding surface; other site 941193000015 beta-clamp/translesion DNA polymerase binding surface; other site 941193000016 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 941193000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193000018 Walker A/P-loop; other site 941193000019 ATP binding site [chemical binding]; other site 941193000020 Q-loop/lid; other site 941193000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193000022 ABC transporter signature motif; other site 941193000023 Walker B; other site 941193000024 D-loop; other site 941193000025 H-loop/switch region; other site 941193000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 941193000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193000028 Mg2+ binding site [ion binding]; other site 941193000029 G-X-G motif; other site 941193000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 941193000031 anchoring element; other site 941193000032 dimer interface [polypeptide binding]; other site 941193000033 ATP binding site [chemical binding]; other site 941193000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 941193000035 active site 941193000036 putative metal-binding site [ion binding]; other site 941193000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 941193000038 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 941193000039 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 941193000040 putative acyl-acceptor binding pocket; other site 941193000041 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 941193000042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941193000043 active site 941193000044 motif I; other site 941193000045 motif II; other site 941193000046 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 941193000047 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 941193000048 dimer interface [polypeptide binding]; other site 941193000049 motif 1; other site 941193000050 active site 941193000051 motif 2; other site 941193000052 motif 3; other site 941193000053 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 941193000054 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 941193000055 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 941193000056 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 941193000057 putative acyl-acceptor binding pocket; other site 941193000058 PilZ domain; Region: PilZ; pfam07238 941193000059 hypothetical protein; Provisional; Region: PRK11212 941193000060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941193000061 TPR motif; other site 941193000062 TPR repeat; Region: TPR_11; pfam13414 941193000063 binding surface 941193000064 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 941193000065 TrkA-N domain; Region: TrkA_N; pfam02254 941193000066 TrkA-C domain; Region: TrkA_C; pfam02080 941193000067 TrkA-N domain; Region: TrkA_N; pfam02254 941193000068 TrkA-C domain; Region: TrkA_C; pfam02080 941193000069 16S rRNA methyltransferase B; Provisional; Region: PRK10901 941193000070 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 941193000071 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 941193000072 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 941193000073 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 941193000074 putative active site [active] 941193000075 substrate binding site [chemical binding]; other site 941193000076 putative cosubstrate binding site; other site 941193000077 catalytic site [active] 941193000078 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 941193000079 substrate binding site [chemical binding]; other site 941193000080 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 941193000081 active site 941193000082 catalytic residues [active] 941193000083 metal binding site [ion binding]; metal-binding site 941193000084 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941193000085 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 941193000086 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 941193000087 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 941193000088 DNA protecting protein DprA; Region: dprA; TIGR00732 941193000089 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 941193000090 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 941193000091 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 941193000092 NADP binding site [chemical binding]; other site 941193000093 dimer interface [polypeptide binding]; other site 941193000094 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 941193000095 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 941193000096 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 941193000097 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 941193000098 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 941193000099 shikimate binding site; other site 941193000100 NAD(P) binding site [chemical binding]; other site 941193000101 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 941193000102 Zn binding site [ion binding]; other site 941193000103 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 941193000104 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 941193000105 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 941193000106 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 941193000107 Sulfate transporter family; Region: Sulfate_transp; pfam00916 941193000108 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 941193000109 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 941193000110 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 941193000111 choline-sulfatase; Region: chol_sulfatase; TIGR03417 941193000112 Sulfatase; Region: Sulfatase; cl17466 941193000113 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 941193000114 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 941193000115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193000116 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 941193000117 dimerization interface [polypeptide binding]; other site 941193000118 substrate binding pocket [chemical binding]; other site 941193000119 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 941193000120 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 941193000121 putative binding surface; other site 941193000122 active site 941193000123 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941193000124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193000125 active site 941193000126 phosphorylation site [posttranslational modification] 941193000127 intermolecular recognition site; other site 941193000128 dimerization interface [polypeptide binding]; other site 941193000129 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193000130 DNA binding residues [nucleotide binding] 941193000131 dimerization interface [polypeptide binding]; other site 941193000132 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 941193000133 substrate binding site [chemical binding]; other site 941193000134 active site 941193000135 catalytic residues [active] 941193000136 heterodimer interface [polypeptide binding]; other site 941193000137 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 941193000138 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 941193000139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193000140 catalytic residue [active] 941193000141 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 941193000142 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193000143 The C-terminal substrate binding domain of LysR-type transcriptional regulator TrpI, which is involved in control of tryptophan synthesis, contains type 2 periplasmic binding fold; Region: PBP2_TrpI; cd08482 941193000144 putative dimerization interface [polypeptide binding]; other site 941193000145 putative substrate binding pocket [chemical binding]; other site 941193000146 Dodecin; Region: Dodecin; pfam07311 941193000147 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 941193000148 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 941193000149 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 941193000150 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 941193000151 haemagglutination activity domain; Region: Haemagg_act; pfam05860 941193000152 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 941193000153 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 941193000154 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 941193000155 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 941193000156 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 941193000157 Predicted membrane protein [Function unknown]; Region: COG3174 941193000158 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 941193000159 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 941193000160 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219 941193000161 switch II binding region; other site 941193000162 Rac1 P-loop interaction site [polypeptide binding]; other site 941193000163 GTP binding residues [chemical binding]; other site 941193000164 switch I binding region; other site 941193000165 ADP-ribosyltransferase exoenzyme; Region: ADPrib_exo_Tox; pfam03496 941193000166 active site 941193000167 conformational flexibility of ligand binding pocket; other site 941193000168 ADP-ribosylating toxin turn-turn motif; other site 941193000169 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 941193000170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 941193000171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 941193000172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941193000173 sequence-specific DNA binding site [nucleotide binding]; other site 941193000174 salt bridge; other site 941193000175 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 941193000176 active site 941193000177 dimer interface [polypeptide binding]; other site 941193000178 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 941193000179 Asparagine synthase; Region: Asn_synthase; pfam00733 941193000180 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 941193000181 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 941193000182 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 941193000183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3812 941193000184 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193000185 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193000186 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941193000187 putative effector binding pocket; other site 941193000188 dimerization interface [polypeptide binding]; other site 941193000189 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 941193000190 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 941193000191 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 941193000192 catalytic residues [active] 941193000193 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 941193000194 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 941193000195 Predicted aminopeptidase (DUF2265); Region: DUF2265; cl17720 941193000196 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 941193000197 Eukaryotic phosphomannomutase; Region: PMM; cl17107 941193000198 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941193000199 motif II; other site 941193000200 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 941193000201 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 941193000202 trimer interface [polypeptide binding]; other site 941193000203 putative metal binding site [ion binding]; other site 941193000204 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 941193000205 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 941193000206 active site 941193000207 Zn binding site [ion binding]; other site 941193000208 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 941193000209 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 941193000210 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 941193000211 FeS/SAM binding site; other site 941193000212 Uncharacterized conserved protein [Function unknown]; Region: COG1262 941193000213 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 941193000214 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 941193000215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193000216 Walker A/P-loop; other site 941193000217 ATP binding site [chemical binding]; other site 941193000218 Q-loop/lid; other site 941193000219 ABC transporter signature motif; other site 941193000220 Walker B; other site 941193000221 D-loop; other site 941193000222 H-loop/switch region; other site 941193000223 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 941193000224 active site 941193000225 Protein phosphatase 2C; Region: PP2C; pfam00481 941193000226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SciT; COG3913 941193000227 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 941193000228 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 941193000229 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 941193000230 hypothetical protein; Provisional; Region: PRK07033 941193000231 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 941193000232 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 941193000233 ligand binding site [chemical binding]; other site 941193000234 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 941193000235 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 941193000236 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 941193000237 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 941193000238 phosphopeptide binding site; other site 941193000239 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 941193000240 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 941193000241 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 941193000242 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 941193000243 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 941193000244 Protein of unknown function (DUF877); Region: DUF877; pfam05943 941193000245 Protein of unknown function (DUF796); Region: DUF796; pfam05638 941193000246 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 941193000247 ImpE protein; Region: ImpE; pfam07024 941193000248 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 941193000249 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 941193000250 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 941193000251 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 941193000252 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 941193000253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193000254 Walker A motif; other site 941193000255 ATP binding site [chemical binding]; other site 941193000256 Walker B motif; other site 941193000257 arginine finger; other site 941193000258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193000259 Walker A motif; other site 941193000260 ATP binding site [chemical binding]; other site 941193000261 Walker B motif; other site 941193000262 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 941193000263 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 941193000264 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 941193000265 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 941193000266 PAAR motif; Region: PAAR_motif; pfam05488 941193000267 Uncharacterized conserved protein [Function unknown]; Region: COG5435 941193000268 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 941193000269 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 941193000270 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 941193000271 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 941193000272 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 941193000273 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 941193000274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5351 941193000275 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 941193000276 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 941193000277 active site 941193000278 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 941193000279 conserved hypothetical protein; Region: TIGR02270 941193000280 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 941193000281 active site clefts [active] 941193000282 zinc binding site [ion binding]; other site 941193000283 dimer interface [polypeptide binding]; other site 941193000284 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 941193000285 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 941193000286 Sulfate transporter family; Region: Sulfate_transp; pfam00916 941193000287 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 941193000288 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 941193000289 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 941193000290 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 941193000291 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 941193000292 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 941193000293 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 941193000294 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 941193000295 Subunit I/III interface [polypeptide binding]; other site 941193000296 D-pathway; other site 941193000297 Subunit I/VIIc interface [polypeptide binding]; other site 941193000298 Subunit I/IV interface [polypeptide binding]; other site 941193000299 Subunit I/II interface [polypeptide binding]; other site 941193000300 Low-spin heme (heme a) binding site [chemical binding]; other site 941193000301 Subunit I/VIIa interface [polypeptide binding]; other site 941193000302 Subunit I/VIa interface [polypeptide binding]; other site 941193000303 Dimer interface; other site 941193000304 Putative water exit pathway; other site 941193000305 Binuclear center (heme a3/CuB) [ion binding]; other site 941193000306 K-pathway; other site 941193000307 Subunit I/Vb interface [polypeptide binding]; other site 941193000308 Putative proton exit pathway; other site 941193000309 Subunit I/VIb interface; other site 941193000310 Subunit I/VIc interface [polypeptide binding]; other site 941193000311 Electron transfer pathway; other site 941193000312 Subunit I/VIIIb interface [polypeptide binding]; other site 941193000313 Subunit I/VIIb interface [polypeptide binding]; other site 941193000314 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 941193000315 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 941193000316 Subunit III/VIIa interface [polypeptide binding]; other site 941193000317 Phospholipid binding site [chemical binding]; other site 941193000318 Subunit I/III interface [polypeptide binding]; other site 941193000319 Subunit III/VIb interface [polypeptide binding]; other site 941193000320 Subunit III/VIa interface; other site 941193000321 Subunit III/Vb interface [polypeptide binding]; other site 941193000322 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 941193000323 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 941193000324 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 941193000325 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 941193000326 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 941193000327 UbiA prenyltransferase family; Region: UbiA; pfam01040 941193000328 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 941193000329 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 941193000330 Cu(I) binding site [ion binding]; other site 941193000331 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 941193000332 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941193000333 Coenzyme A binding pocket [chemical binding]; other site 941193000334 Predicted transcriptional regulators [Transcription]; Region: COG1733 941193000335 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 941193000336 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 941193000337 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 941193000338 putative NAD(P) binding site [chemical binding]; other site 941193000339 active site 941193000340 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 941193000341 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 941193000342 putative catalytic residue [active] 941193000343 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 941193000344 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 941193000345 Transcriptional regulators [Transcription]; Region: FadR; COG2186 941193000346 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193000347 DNA-binding site [nucleotide binding]; DNA binding site 941193000348 FCD domain; Region: FCD; pfam07729 941193000349 Transcriptional regulators [Transcription]; Region: GntR; COG1802 941193000350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 941193000351 DNA-binding site [nucleotide binding]; DNA binding site 941193000352 FCD domain; Region: FCD; pfam07729 941193000353 Aegerolysin; Region: Aegerolysin; pfam06355 941193000354 transcriptional regulator; Provisional; Region: PRK10632 941193000355 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193000356 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941193000357 putative effector binding pocket; other site 941193000358 dimerization interface [polypeptide binding]; other site 941193000359 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 941193000360 Predicted transcriptional regulator [Transcription]; Region: COG3905 941193000361 Water Stress and Hypersensitive response; Region: WHy; smart00769 941193000362 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 941193000363 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 941193000364 PhnA protein; Region: PhnA; pfam03831 941193000365 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 941193000366 Spore germination protein; Region: Spore_permease; cl17796 941193000367 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 941193000368 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 941193000369 tetrameric interface [polypeptide binding]; other site 941193000370 NAD binding site [chemical binding]; other site 941193000371 catalytic residues [active] 941193000372 Cupin domain; Region: Cupin_2; cl17218 941193000373 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 941193000374 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941193000375 inhibitor-cofactor binding pocket; inhibition site 941193000376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193000377 catalytic residue [active] 941193000378 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193000379 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193000380 LysR substrate binding domain; Region: LysR_substrate; pfam03466 941193000381 dimerization interface [polypeptide binding]; other site 941193000382 guanine deaminase; Provisional; Region: PRK09228 941193000383 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 941193000384 active site 941193000385 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 941193000386 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 941193000387 Walker A/P-loop; other site 941193000388 ATP binding site [chemical binding]; other site 941193000389 Q-loop/lid; other site 941193000390 ABC transporter signature motif; other site 941193000391 Walker B; other site 941193000392 D-loop; other site 941193000393 H-loop/switch region; other site 941193000394 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 941193000395 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941193000396 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 941193000397 TM-ABC transporter signature motif; other site 941193000398 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941193000399 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 941193000400 TM-ABC transporter signature motif; other site 941193000401 peroxiredoxin; Region: AhpC; TIGR03137 941193000402 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 941193000403 dimer interface [polypeptide binding]; other site 941193000404 decamer (pentamer of dimers) interface [polypeptide binding]; other site 941193000405 catalytic triad [active] 941193000406 peroxidatic and resolving cysteines [active] 941193000407 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 941193000408 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 941193000409 catalytic residue [active] 941193000410 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 941193000411 catalytic residues [active] 941193000412 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941193000413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941193000414 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 941193000415 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 941193000416 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 941193000417 active site 941193000418 putative substrate binding pocket [chemical binding]; other site 941193000419 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 941193000420 active site 941193000421 tetramer interface [polypeptide binding]; other site 941193000422 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 941193000423 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 941193000424 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 941193000425 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 941193000426 putative ligand binding site [chemical binding]; other site 941193000427 oxidase reductase; Provisional; Region: PTZ00273 941193000428 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 941193000429 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 941193000430 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 941193000431 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 941193000432 active site 941193000433 purine riboside binding site [chemical binding]; other site 941193000434 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 941193000435 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941193000436 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941193000437 DNA binding residues [nucleotide binding] 941193000438 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 941193000439 FecR protein; Region: FecR; pfam04773 941193000440 Secretin and TonB N terminus short domain; Region: STN; smart00965 941193000441 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 941193000442 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193000443 N-terminal plug; other site 941193000444 ligand-binding site [chemical binding]; other site 941193000445 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 941193000446 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193000447 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193000448 dimerization interface [polypeptide binding]; other site 941193000449 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 941193000450 heterodimer interface [polypeptide binding]; other site 941193000451 multimer interface [polypeptide binding]; other site 941193000452 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 941193000453 active site 941193000454 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 941193000455 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 941193000456 heterodimer interface [polypeptide binding]; other site 941193000457 active site 941193000458 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 941193000459 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 941193000460 Bacterial transcriptional regulator; Region: IclR; pfam01614 941193000461 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 941193000462 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193000463 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193000464 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 941193000465 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193000466 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193000467 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 941193000468 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193000469 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193000470 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941193000471 putative effector binding pocket; other site 941193000472 dimerization interface [polypeptide binding]; other site 941193000473 outer membrane porin, OprD family; Region: OprD; pfam03573 941193000474 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 941193000475 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193000476 Helix-turn-helix domain; Region: HTH_18; pfam12833 941193000477 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 941193000478 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 941193000479 Nucleoside-binding outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: Tsx; COG3248 941193000480 xanthine permease; Region: pbuX; TIGR03173 941193000481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193000482 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 941193000483 Uncharacterized conserved protein [Function unknown]; Region: COG1739 941193000484 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 941193000485 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 941193000486 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193000487 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193000488 metal binding site [ion binding]; metal-binding site 941193000489 active site 941193000490 I-site; other site 941193000491 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 941193000492 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193000493 dimerization interface [polypeptide binding]; other site 941193000494 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 941193000495 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 941193000496 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 941193000497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193000498 active site 941193000499 phosphorylation site [posttranslational modification] 941193000500 intermolecular recognition site; other site 941193000501 dimerization interface [polypeptide binding]; other site 941193000502 CheB methylesterase; Region: CheB_methylest; pfam01339 941193000503 CheD chemotactic sensory transduction; Region: CheD; cl00810 941193000504 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 941193000505 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 941193000506 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 941193000507 PAS domain; Region: PAS; smart00091 941193000508 PAS domain; Region: PAS_9; pfam13426 941193000509 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941193000510 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193000511 dimer interface [polypeptide binding]; other site 941193000512 putative CheW interface [polypeptide binding]; other site 941193000513 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 941193000514 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 941193000515 putative binding surface; other site 941193000516 active site 941193000517 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 941193000518 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 941193000519 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193000520 ATP binding site [chemical binding]; other site 941193000521 G-X-G motif; other site 941193000522 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 941193000523 Response regulator receiver domain; Region: Response_reg; pfam00072 941193000524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193000525 active site 941193000526 phosphorylation site [posttranslational modification] 941193000527 intermolecular recognition site; other site 941193000528 dimerization interface [polypeptide binding]; other site 941193000529 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 941193000530 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193000531 putative CheW interface [polypeptide binding]; other site 941193000532 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193000533 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193000534 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941193000535 putative effector binding pocket; other site 941193000536 dimerization interface [polypeptide binding]; other site 941193000537 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 941193000538 classical (c) SDRs; Region: SDR_c; cd05233 941193000539 NAD(P) binding site [chemical binding]; other site 941193000540 active site 941193000541 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 941193000542 Sulfatase; Region: Sulfatase; pfam00884 941193000543 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 941193000544 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 941193000545 Walker A/P-loop; other site 941193000546 ATP binding site [chemical binding]; other site 941193000547 Q-loop/lid; other site 941193000548 ABC transporter signature motif; other site 941193000549 Walker B; other site 941193000550 D-loop; other site 941193000551 H-loop/switch region; other site 941193000552 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 941193000553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 941193000554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 941193000555 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 941193000556 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 941193000557 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 941193000558 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 941193000559 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 941193000560 substrate binding pocket [chemical binding]; other site 941193000561 active site 941193000562 iron coordination sites [ion binding]; other site 941193000563 Predicted permeases [General function prediction only]; Region: COG0679 941193000564 outer membrane porin, OprD family; Region: OprD; pfam03573 941193000565 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 941193000566 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 941193000567 active site 941193000568 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193000569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193000570 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941193000571 dimerization interface [polypeptide binding]; other site 941193000572 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 941193000573 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193000574 N-terminal plug; other site 941193000575 ligand-binding site [chemical binding]; other site 941193000576 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 941193000577 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 941193000578 active site 941193000579 iron coordination sites [ion binding]; other site 941193000580 substrate binding pocket [chemical binding]; other site 941193000581 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 941193000582 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 941193000583 active site 941193000584 iron coordination sites [ion binding]; other site 941193000585 substrate binding pocket [chemical binding]; other site 941193000586 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 941193000587 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 941193000588 ligand binding site [chemical binding]; other site 941193000589 homodimer interface [polypeptide binding]; other site 941193000590 NAD(P) binding site [chemical binding]; other site 941193000591 trimer interface B [polypeptide binding]; other site 941193000592 trimer interface A [polypeptide binding]; other site 941193000593 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 941193000594 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 941193000595 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 941193000596 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 941193000597 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 941193000598 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 941193000599 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 941193000600 TolR protein; Region: tolR; TIGR02801 941193000601 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 941193000602 Serine hydrolase; Region: Ser_hydrolase; pfam06821 941193000603 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 941193000604 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 941193000605 Coenzyme A transferase; Region: CoA_trans; cl17247 941193000606 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 941193000607 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 941193000608 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 941193000609 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 941193000610 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 941193000611 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833 941193000612 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 941193000613 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 941193000614 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 941193000615 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 941193000616 Malonate transporter MadL subunit; Region: MadL; cl04273 941193000617 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 941193000618 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193000619 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193000620 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 941193000621 putative dimerization interface [polypeptide binding]; other site 941193000622 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193000623 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193000624 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 941193000625 putative substrate binding pocket [chemical binding]; other site 941193000626 dimerization interface [polypeptide binding]; other site 941193000627 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 941193000628 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 941193000629 NAD(P) binding site [chemical binding]; other site 941193000630 catalytic residues [active] 941193000631 amino acid transporter; Region: 2A0306; TIGR00909 941193000632 putative aminotransferase; Provisional; Region: PRK12403 941193000633 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941193000634 inhibitor-cofactor binding pocket; inhibition site 941193000635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193000636 catalytic residue [active] 941193000637 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 941193000638 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 941193000639 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 941193000640 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 941193000641 inhibitor site; inhibition site 941193000642 active site 941193000643 dimer interface [polypeptide binding]; other site 941193000644 catalytic residue [active] 941193000645 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 941193000646 intersubunit interface [polypeptide binding]; other site 941193000647 active site 941193000648 Zn2+ binding site [ion binding]; other site 941193000649 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 941193000650 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941193000651 sequence-specific DNA binding site [nucleotide binding]; other site 941193000652 salt bridge; other site 941193000653 Cupin domain; Region: Cupin_2; pfam07883 941193000654 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 941193000655 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 941193000656 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 941193000657 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 941193000658 dimer interface [polypeptide binding]; other site 941193000659 active site 941193000660 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 941193000661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193000662 putative substrate translocation pore; other site 941193000663 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 941193000664 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 941193000665 tetramer interface [polypeptide binding]; other site 941193000666 active site 941193000667 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 941193000668 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 941193000669 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193000670 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193000671 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193000672 dimerization interface [polypeptide binding]; other site 941193000673 benzoate transport; Region: 2A0115; TIGR00895 941193000674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193000675 putative substrate translocation pore; other site 941193000676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193000677 Transcriptional regulator [Transcription]; Region: IclR; COG1414 941193000678 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 941193000679 Bacterial transcriptional regulator; Region: IclR; pfam01614 941193000680 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 941193000681 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 941193000682 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 941193000683 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 941193000684 EamA-like transporter family; Region: EamA; pfam00892 941193000685 outer membrane porin, OprD family; Region: OprD; pfam03573 941193000686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193000687 D-galactonate transporter; Region: 2A0114; TIGR00893 941193000688 putative substrate translocation pore; other site 941193000689 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 941193000690 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 941193000691 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 941193000692 dimer interface [polypeptide binding]; other site 941193000693 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 941193000694 active site 941193000695 Fe binding site [ion binding]; other site 941193000696 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193000697 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193000698 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 941193000699 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 941193000700 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 941193000701 shikimate binding site; other site 941193000702 NAD(P) binding site [chemical binding]; other site 941193000703 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 941193000704 Dehydroquinase class II; Region: DHquinase_II; pfam01220 941193000705 active site 941193000706 trimer interface [polypeptide binding]; other site 941193000707 dimer interface [polypeptide binding]; other site 941193000708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193000709 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941193000710 putative substrate translocation pore; other site 941193000711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193000712 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 941193000713 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941193000714 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 941193000715 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 941193000716 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941193000717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193000718 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 941193000719 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941193000720 Coenzyme A binding pocket [chemical binding]; other site 941193000721 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 941193000722 FOG: CBS domain [General function prediction only]; Region: COG0517 941193000723 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 941193000724 MarR family; Region: MarR_2; cl17246 941193000725 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 941193000726 Predicted membrane protein [Function unknown]; Region: COG3619 941193000727 Integrase core domain; Region: rve_3; pfam13683 941193000728 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 941193000729 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 941193000730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 941193000731 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 941193000732 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 941193000733 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 941193000734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 941193000735 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 941193000736 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 941193000737 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 941193000738 tetramerization interface [polypeptide binding]; other site 941193000739 NAD(P) binding site [chemical binding]; other site 941193000740 catalytic residues [active] 941193000741 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 941193000742 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941193000743 inhibitor-cofactor binding pocket; inhibition site 941193000744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193000745 catalytic residue [active] 941193000746 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 941193000747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193000748 active site 941193000749 phosphorylation site [posttranslational modification] 941193000750 intermolecular recognition site; other site 941193000751 dimerization interface [polypeptide binding]; other site 941193000752 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 941193000753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193000754 DNA-binding site [nucleotide binding]; DNA binding site 941193000755 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 941193000756 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941193000757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193000758 homodimer interface [polypeptide binding]; other site 941193000759 catalytic residue [active] 941193000760 Uncharacterized conserved protein [Function unknown]; Region: COG2128 941193000761 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 941193000762 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 941193000763 Uncharacterized conserved protein [Function unknown]; Region: COG1359 941193000764 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193000765 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193000766 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 941193000767 substrate binding pocket [chemical binding]; other site 941193000768 dimerization interface [polypeptide binding]; other site 941193000769 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 941193000770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193000771 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 941193000772 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 941193000773 ligand binding site [chemical binding]; other site 941193000774 flexible hinge region; other site 941193000775 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 941193000776 Protein of unknown function (DUF962); Region: DUF962; cl01879 941193000777 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 941193000778 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 941193000779 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941193000780 dimerization interface [polypeptide binding]; other site 941193000781 putative DNA binding site [nucleotide binding]; other site 941193000782 putative Zn2+ binding site [ion binding]; other site 941193000783 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 941193000784 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 941193000785 Walker A/P-loop; other site 941193000786 ATP binding site [chemical binding]; other site 941193000787 Q-loop/lid; other site 941193000788 ABC transporter signature motif; other site 941193000789 Walker B; other site 941193000790 D-loop; other site 941193000791 H-loop/switch region; other site 941193000792 TOBE-like domain; Region: TOBE_3; pfam12857 941193000793 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 941193000794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193000795 dimer interface [polypeptide binding]; other site 941193000796 conserved gate region; other site 941193000797 putative PBP binding loops; other site 941193000798 ABC-ATPase subunit interface; other site 941193000799 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 941193000800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193000801 dimer interface [polypeptide binding]; other site 941193000802 conserved gate region; other site 941193000803 putative PBP binding loops; other site 941193000804 ABC-ATPase subunit interface; other site 941193000805 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 941193000806 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 941193000807 Uncharacterized small protein [Function unknown]; Region: COG5583 941193000808 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193000809 PAS fold; Region: PAS_3; pfam08447 941193000810 putative active site [active] 941193000811 heme pocket [chemical binding]; other site 941193000812 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193000813 PAS domain; Region: PAS_9; pfam13426 941193000814 putative active site [active] 941193000815 heme pocket [chemical binding]; other site 941193000816 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193000817 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193000818 metal binding site [ion binding]; metal-binding site 941193000819 active site 941193000820 I-site; other site 941193000821 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941193000822 Fatty acid desaturase; Region: FA_desaturase; pfam00487 941193000823 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 941193000824 Di-iron ligands [ion binding]; other site 941193000825 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 941193000826 Transposase; Region: DDE_Tnp_ISL3; pfam01610 941193000827 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 941193000828 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 941193000829 Na binding site [ion binding]; other site 941193000830 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 941193000831 agmatinase; Region: agmatinase; TIGR01230 941193000832 oligomer interface [polypeptide binding]; other site 941193000833 putative active site [active] 941193000834 Mn binding site [ion binding]; other site 941193000835 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193000836 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193000837 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941193000838 dimerization interface [polypeptide binding]; other site 941193000839 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193000840 PAS fold; Region: PAS_3; pfam08447 941193000841 putative active site [active] 941193000842 heme pocket [chemical binding]; other site 941193000843 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193000844 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193000845 metal binding site [ion binding]; metal-binding site 941193000846 active site 941193000847 I-site; other site 941193000848 outer membrane porin, OprD family; Region: OprD; pfam03573 941193000849 agmatine deiminase; Provisional; Region: PRK13551 941193000850 agmatine deiminase; Region: agmatine_aguA; TIGR03380 941193000851 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 941193000852 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 941193000853 putative active site; other site 941193000854 catalytic triad [active] 941193000855 putative dimer interface [polypeptide binding]; other site 941193000856 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193000857 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193000858 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 941193000859 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941193000860 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 941193000861 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 941193000862 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 941193000863 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 941193000864 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 941193000865 catalytic triad [active] 941193000866 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 941193000867 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 941193000868 putative aminotransferase; Validated; Region: PRK07480 941193000869 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941193000870 inhibitor-cofactor binding pocket; inhibition site 941193000871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193000872 catalytic residue [active] 941193000873 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 941193000874 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941193000875 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 941193000876 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941193000877 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 941193000878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193000879 Walker A/P-loop; other site 941193000880 ATP binding site [chemical binding]; other site 941193000881 Q-loop/lid; other site 941193000882 ABC transporter signature motif; other site 941193000883 Walker B; other site 941193000884 D-loop; other site 941193000885 H-loop/switch region; other site 941193000886 TOBE domain; Region: TOBE_2; pfam08402 941193000887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193000888 dimer interface [polypeptide binding]; other site 941193000889 conserved gate region; other site 941193000890 putative PBP binding loops; other site 941193000891 ABC-ATPase subunit interface; other site 941193000892 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 941193000893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193000894 dimer interface [polypeptide binding]; other site 941193000895 conserved gate region; other site 941193000896 putative PBP binding loops; other site 941193000897 ABC-ATPase subunit interface; other site 941193000898 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 941193000899 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 941193000900 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 941193000901 active site 941193000902 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 941193000903 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941193000904 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 941193000905 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 941193000906 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 941193000907 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 941193000908 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 941193000909 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 941193000910 Uncharacterized conserved protein [Function unknown]; Region: COG1683 941193000911 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 941193000912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193000913 dimer interface [polypeptide binding]; other site 941193000914 conserved gate region; other site 941193000915 putative PBP binding loops; other site 941193000916 ABC-ATPase subunit interface; other site 941193000917 cystine transporter subunit; Provisional; Region: PRK11260 941193000918 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193000919 substrate binding pocket [chemical binding]; other site 941193000920 membrane-bound complex binding site; other site 941193000921 hinge residues; other site 941193000922 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 941193000923 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 941193000924 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 941193000925 ligand binding site [chemical binding]; other site 941193000926 NAD binding site [chemical binding]; other site 941193000927 tetramer interface [polypeptide binding]; other site 941193000928 catalytic site [active] 941193000929 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 941193000930 L-serine binding site [chemical binding]; other site 941193000931 ACT domain interface; other site 941193000932 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 941193000933 FAD binding domain; Region: FAD_binding_4; pfam01565 941193000934 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 941193000935 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 941193000936 SdiA-regulated; Region: SdiA-regulated; pfam06977 941193000937 SdiA-regulated; Region: SdiA-regulated; cd09971 941193000938 putative active site [active] 941193000939 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 941193000940 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 941193000941 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 941193000942 active site 941193000943 Zn binding site [ion binding]; other site 941193000944 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 941193000945 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 941193000946 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 941193000947 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 941193000948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193000949 dimer interface [polypeptide binding]; other site 941193000950 conserved gate region; other site 941193000951 putative PBP binding loops; other site 941193000952 ABC-ATPase subunit interface; other site 941193000953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193000954 dimer interface [polypeptide binding]; other site 941193000955 conserved gate region; other site 941193000956 putative PBP binding loops; other site 941193000957 ABC-ATPase subunit interface; other site 941193000958 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 941193000959 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193000960 Walker A/P-loop; other site 941193000961 ATP binding site [chemical binding]; other site 941193000962 Q-loop/lid; other site 941193000963 ABC transporter signature motif; other site 941193000964 Walker B; other site 941193000965 D-loop; other site 941193000966 H-loop/switch region; other site 941193000967 TOBE domain; Region: TOBE_2; pfam08402 941193000968 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 941193000969 SdiA-regulated; Region: SdiA-regulated; cd09971 941193000970 putative active site [active] 941193000971 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 941193000972 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 941193000973 metal binding site [ion binding]; metal-binding site 941193000974 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 941193000975 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 941193000976 trimer interface [polypeptide binding]; other site 941193000977 active site 941193000978 substrate binding site [chemical binding]; other site 941193000979 CoA binding site [chemical binding]; other site 941193000980 Uncharacterized conserved protein [Function unknown]; Region: COG3422 941193000981 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 941193000982 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 941193000983 tetramer (dimer of dimers) interface [polypeptide binding]; other site 941193000984 active site 941193000985 dimer interface [polypeptide binding]; other site 941193000986 threonine dehydratase; Reviewed; Region: PRK09224 941193000987 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 941193000988 tetramer interface [polypeptide binding]; other site 941193000989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193000990 catalytic residue [active] 941193000991 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 941193000992 putative Ile/Val binding site [chemical binding]; other site 941193000993 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 941193000994 putative Ile/Val binding site [chemical binding]; other site 941193000995 Predicted integral membrane protein [Function unknown]; Region: COG5528 941193000996 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 941193000997 NADH(P)-binding; Region: NAD_binding_10; pfam13460 941193000998 putative NAD(P) binding site [chemical binding]; other site 941193000999 active site 941193001000 DoxX-like family; Region: DoxX_3; pfam13781 941193001001 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 941193001002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193001003 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941193001004 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 941193001005 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 941193001006 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 941193001007 putative active site [active] 941193001008 Ap4A binding site [chemical binding]; other site 941193001009 nudix motif; other site 941193001010 putative metal binding site [ion binding]; other site 941193001011 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 941193001012 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 941193001013 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 941193001014 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 941193001015 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 941193001016 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193001017 PAS fold; Region: PAS_3; pfam08447 941193001018 putative active site [active] 941193001019 heme pocket [chemical binding]; other site 941193001020 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193001021 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193001022 metal binding site [ion binding]; metal-binding site 941193001023 active site 941193001024 I-site; other site 941193001025 Uncharacterized conserved protein [Function unknown]; Region: COG3332 941193001026 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 941193001027 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 941193001028 thymidylate synthase; Reviewed; Region: thyA; PRK01827 941193001029 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 941193001030 dimerization interface [polypeptide binding]; other site 941193001031 active site 941193001032 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 941193001033 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 941193001034 G1 box; other site 941193001035 GTP/Mg2+ binding site [chemical binding]; other site 941193001036 G2 box; other site 941193001037 Switch I region; other site 941193001038 G3 box; other site 941193001039 Switch II region; other site 941193001040 G4 box; other site 941193001041 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 941193001042 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 941193001043 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 941193001044 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 941193001045 putative active site [active] 941193001046 catalytic site [active] 941193001047 putative metal binding site [ion binding]; other site 941193001048 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 941193001049 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 941193001050 folate binding site [chemical binding]; other site 941193001051 NADP+ binding site [chemical binding]; other site 941193001052 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 941193001053 active site 941193001054 metal binding site [ion binding]; metal-binding site 941193001055 homotetramer interface [polypeptide binding]; other site 941193001056 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 941193001057 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 941193001058 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 941193001059 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 941193001060 putative RNA binding site [nucleotide binding]; other site 941193001061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193001062 S-adenosylmethionine binding site [chemical binding]; other site 941193001063 intracellular protease, PfpI family; Region: PfpI; TIGR01382 941193001064 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 941193001065 proposed catalytic triad [active] 941193001066 conserved cys residue [active] 941193001067 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 941193001068 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 941193001069 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 941193001070 DNA binding site [nucleotide binding] 941193001071 catalytic residue [active] 941193001072 H2TH interface [polypeptide binding]; other site 941193001073 putative catalytic residues [active] 941193001074 turnover-facilitating residue; other site 941193001075 intercalation triad [nucleotide binding]; other site 941193001076 8OG recognition residue [nucleotide binding]; other site 941193001077 putative reading head residues; other site 941193001078 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 941193001079 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 941193001080 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 941193001081 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 941193001082 putative acyl-acceptor binding pocket; other site 941193001083 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 941193001084 Sel1-like repeats; Region: SEL1; smart00671 941193001085 Sel1-like repeats; Region: SEL1; smart00671 941193001086 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 941193001087 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 941193001088 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 941193001089 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 941193001090 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 941193001091 active site 941193001092 (T/H)XGH motif; other site 941193001093 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 941193001094 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 941193001095 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 941193001096 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 941193001097 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 941193001098 NAD(P) binding site [chemical binding]; other site 941193001099 catalytic residues [active] 941193001100 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193001101 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193001102 Bacterial transcriptional repressor; Region: TetR; pfam13972 941193001103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941193001104 Coenzyme A binding pocket [chemical binding]; other site 941193001105 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 941193001106 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 941193001107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193001108 S-adenosylmethionine binding site [chemical binding]; other site 941193001109 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 941193001110 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 941193001111 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 941193001112 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 941193001113 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 941193001114 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 941193001115 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 941193001116 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 941193001117 P loop; other site 941193001118 GTP binding site [chemical binding]; other site 941193001119 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 941193001120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193001121 Walker A/P-loop; other site 941193001122 ATP binding site [chemical binding]; other site 941193001123 Q-loop/lid; other site 941193001124 ABC transporter signature motif; other site 941193001125 Walker B; other site 941193001126 D-loop; other site 941193001127 H-loop/switch region; other site 941193001128 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 941193001129 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 941193001130 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 941193001131 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 941193001132 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941193001133 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941193001134 DNA binding residues [nucleotide binding] 941193001135 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 941193001136 monofunctional biosynthetic peptidoglycan transglycosylase; Region: mono_pep_trsgly; TIGR02070 941193001137 Protein of unknown function (DUF423); Region: DUF423; pfam04241 941193001138 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 941193001139 thiS-thiF/thiG interaction site; other site 941193001140 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 941193001141 ThiS interaction site; other site 941193001142 putative active site [active] 941193001143 tetramer interface [polypeptide binding]; other site 941193001144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193001145 S-adenosylmethionine binding site [chemical binding]; other site 941193001146 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 941193001147 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 941193001148 HemN family oxidoreductase; Provisional; Region: PRK05660 941193001149 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941193001150 FeS/SAM binding site; other site 941193001151 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 941193001152 active site 941193001153 dimerization interface [polypeptide binding]; other site 941193001154 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 941193001155 Methyltransferase domain; Region: Methyltransf_31; pfam13847 941193001156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193001157 S-adenosylmethionine binding site [chemical binding]; other site 941193001158 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 941193001159 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 941193001160 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 941193001161 G1 box; other site 941193001162 GTP/Mg2+ binding site [chemical binding]; other site 941193001163 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 941193001164 G2 box; other site 941193001165 Switch I region; other site 941193001166 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 941193001167 G3 box; other site 941193001168 Switch II region; other site 941193001169 GTP/Mg2+ binding site [chemical binding]; other site 941193001170 G4 box; other site 941193001171 G5 box; other site 941193001172 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 941193001173 YGGT family; Region: YGGT; pfam02325 941193001174 YGGT family; Region: YGGT; pfam02325 941193001175 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 941193001176 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 941193001177 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 941193001178 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941193001179 catalytic residue [active] 941193001180 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 941193001181 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 941193001182 Walker A motif; other site 941193001183 ATP binding site [chemical binding]; other site 941193001184 Walker B motif; other site 941193001185 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 941193001186 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 941193001187 Walker A motif; other site 941193001188 ATP binding site [chemical binding]; other site 941193001189 Walker B motif; other site 941193001190 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 941193001191 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 941193001192 TM2 domain; Region: TM2; cl00984 941193001193 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 941193001194 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 941193001195 dimer interface [polypeptide binding]; other site 941193001196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193001197 catalytic residue [active] 941193001198 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 941193001199 FOG: CBS domain [General function prediction only]; Region: COG0517 941193001200 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 941193001201 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 941193001202 homodimer interface [polypeptide binding]; other site 941193001203 substrate-cofactor binding pocket; other site 941193001204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193001205 catalytic residue [active] 941193001206 dihydroorotase; Validated; Region: pyrC; PRK09357 941193001207 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 941193001208 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 941193001209 active site 941193001210 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 941193001211 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 941193001212 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 941193001213 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 941193001214 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941193001215 active site 941193001216 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 941193001217 hypothetical protein; Validated; Region: PRK00228 941193001218 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 941193001219 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 941193001220 glutathione synthetase; Provisional; Region: PRK05246 941193001221 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 941193001222 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 941193001223 Response regulator receiver domain; Region: Response_reg; pfam00072 941193001224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193001225 active site 941193001226 phosphorylation site [posttranslational modification] 941193001227 intermolecular recognition site; other site 941193001228 dimerization interface [polypeptide binding]; other site 941193001229 Response regulator receiver domain; Region: Response_reg; pfam00072 941193001230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193001231 active site 941193001232 phosphorylation site [posttranslational modification] 941193001233 intermolecular recognition site; other site 941193001234 dimerization interface [polypeptide binding]; other site 941193001235 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 941193001236 putative CheA interaction surface; other site 941193001237 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 941193001238 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941193001239 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193001240 dimer interface [polypeptide binding]; other site 941193001241 putative CheW interface [polypeptide binding]; other site 941193001242 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 941193001243 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 941193001244 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 941193001245 Hpt domain; Region: Hpt; pfam01627 941193001246 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 941193001247 putative binding surface; other site 941193001248 active site 941193001249 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 941193001250 putative binding surface; other site 941193001251 active site 941193001252 Hpt domain; Region: Hpt; pfam01627 941193001253 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 941193001254 putative binding surface; other site 941193001255 active site 941193001256 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 941193001257 putative binding surface; other site 941193001258 active site 941193001259 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 941193001260 putative binding surface; other site 941193001261 active site 941193001262 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 941193001263 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 941193001264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193001265 ATP binding site [chemical binding]; other site 941193001266 Mg2+ binding site [ion binding]; other site 941193001267 G-X-G motif; other site 941193001268 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 941193001269 Response regulator receiver domain; Region: Response_reg; pfam00072 941193001270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193001271 active site 941193001272 phosphorylation site [posttranslational modification] 941193001273 intermolecular recognition site; other site 941193001274 dimerization interface [polypeptide binding]; other site 941193001275 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 941193001276 CheB methylesterase; Region: CheB_methylest; pfam01339 941193001277 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 941193001278 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 941193001279 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941193001280 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193001281 LysE type translocator; Region: LysE; pfam01810 941193001282 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 941193001283 RNA methyltransferase, RsmE family; Region: TIGR00046 941193001284 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030 941193001285 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941193001286 inhibitor-cofactor binding pocket; inhibition site 941193001287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193001288 catalytic residue [active] 941193001289 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 941193001290 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941193001291 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 941193001292 hypothetical protein; Provisional; Region: PRK03757 941193001293 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941193001294 MarR family; Region: MarR; pfam01047 941193001295 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 941193001296 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193001297 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193001298 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 941193001299 Protein export membrane protein; Region: SecD_SecF; cl14618 941193001300 Protein export membrane protein; Region: SecD_SecF; cl14618 941193001301 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 941193001302 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 941193001303 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 941193001304 ATP binding site [chemical binding]; other site 941193001305 Mg++ binding site [ion binding]; other site 941193001306 motif III; other site 941193001307 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941193001308 nucleotide binding region [chemical binding]; other site 941193001309 ATP-binding site [chemical binding]; other site 941193001310 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 941193001311 FAD binding site [chemical binding]; other site 941193001312 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 941193001313 HD domain; Region: HD_4; pfam13328 941193001314 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 941193001315 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 941193001316 homotetramer interface [polypeptide binding]; other site 941193001317 ligand binding site [chemical binding]; other site 941193001318 catalytic site [active] 941193001319 NAD binding site [chemical binding]; other site 941193001320 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 941193001321 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193001322 N-terminal plug; other site 941193001323 ligand-binding site [chemical binding]; other site 941193001324 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 941193001325 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 941193001326 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 941193001327 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193001328 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 941193001329 cytosine deaminase; Provisional; Region: PRK09230 941193001330 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 941193001331 active site 941193001332 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 941193001333 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 941193001334 Na binding site [ion binding]; other site 941193001335 putative substrate binding site [chemical binding]; other site 941193001336 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 941193001337 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 941193001338 homodimer interface [polypeptide binding]; other site 941193001339 active site 941193001340 FMN binding site [chemical binding]; other site 941193001341 substrate binding site [chemical binding]; other site 941193001342 4Fe-4S binding domain; Region: Fer4_6; pfam12837 941193001343 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 941193001344 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941193001345 phenylhydantoinase; Validated; Region: PRK08323 941193001346 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 941193001347 tetramer interface [polypeptide binding]; other site 941193001348 active site 941193001349 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 941193001350 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 941193001351 Na binding site [ion binding]; other site 941193001352 putative substrate binding site [chemical binding]; other site 941193001353 allantoate amidohydrolase; Reviewed; Region: PRK09290 941193001354 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 941193001355 active site 941193001356 metal binding site [ion binding]; metal-binding site 941193001357 dimer interface [polypeptide binding]; other site 941193001358 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 941193001359 CoA-transferase family III; Region: CoA_transf_3; pfam02515 941193001360 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 941193001361 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941193001362 FAD binding site [chemical binding]; other site 941193001363 substrate binding pocket [chemical binding]; other site 941193001364 catalytic base [active] 941193001365 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 941193001366 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193001367 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 941193001368 dimerization interface [polypeptide binding]; other site 941193001369 substrate binding pocket [chemical binding]; other site 941193001370 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 941193001371 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 941193001372 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 941193001373 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 941193001374 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 941193001375 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 941193001376 dimer interface [polypeptide binding]; other site 941193001377 active site residues [active] 941193001378 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 941193001379 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 941193001380 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 941193001381 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941193001382 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193001383 substrate binding pocket [chemical binding]; other site 941193001384 membrane-bound complex binding site; other site 941193001385 hinge residues; other site 941193001386 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 941193001387 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 941193001388 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 941193001389 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 941193001390 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 941193001391 ATP binding site [chemical binding]; other site 941193001392 Mg++ binding site [ion binding]; other site 941193001393 motif III; other site 941193001394 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941193001395 nucleotide binding region [chemical binding]; other site 941193001396 ATP-binding site [chemical binding]; other site 941193001397 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 941193001398 putative RNA binding site [nucleotide binding]; other site 941193001399 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 941193001400 DNA-binding site [nucleotide binding]; DNA binding site 941193001401 RNA-binding motif; other site 941193001402 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 941193001403 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 941193001404 putative transporter; Provisional; Region: PRK10504 941193001405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193001406 putative substrate translocation pore; other site 941193001407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193001408 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 941193001409 Clp amino terminal domain; Region: Clp_N; pfam02861 941193001410 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193001411 Walker A motif; other site 941193001412 ATP binding site [chemical binding]; other site 941193001413 Walker B motif; other site 941193001414 arginine finger; other site 941193001415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193001416 Walker A motif; other site 941193001417 ATP binding site [chemical binding]; other site 941193001418 Walker B motif; other site 941193001419 arginine finger; other site 941193001420 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 941193001421 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 941193001422 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 941193001423 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 941193001424 putative acyl-acceptor binding pocket; other site 941193001425 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 941193001426 DNA-binding response regulator CreB; Provisional; Region: PRK11083 941193001427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193001428 active site 941193001429 phosphorylation site [posttranslational modification] 941193001430 intermolecular recognition site; other site 941193001431 dimerization interface [polypeptide binding]; other site 941193001432 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193001433 DNA binding site [nucleotide binding] 941193001434 sensory histidine kinase CreC; Provisional; Region: PRK11100 941193001435 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193001436 dimer interface [polypeptide binding]; other site 941193001437 phosphorylation site [posttranslational modification] 941193001438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193001439 ATP binding site [chemical binding]; other site 941193001440 G-X-G motif; other site 941193001441 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 941193001442 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 941193001443 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 941193001444 putative C-terminal domain interface [polypeptide binding]; other site 941193001445 putative GSH binding site (G-site) [chemical binding]; other site 941193001446 putative dimer interface [polypeptide binding]; other site 941193001447 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 941193001448 N-terminal domain interface [polypeptide binding]; other site 941193001449 dimer interface [polypeptide binding]; other site 941193001450 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 941193001451 Protein phosphatase 2C; Region: PP2C_2; pfam13672 941193001452 Secretin and TonB N terminus short domain; Region: STN; smart00965 941193001453 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 941193001454 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193001455 N-terminal plug; other site 941193001456 ligand-binding site [chemical binding]; other site 941193001457 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 941193001458 FecR protein; Region: FecR; pfam04773 941193001459 RNA polymerase sigma factor; Reviewed; Region: PRK12523 941193001460 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941193001461 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941193001462 DNA binding residues [nucleotide binding] 941193001463 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 941193001464 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 941193001465 C-terminal domain interface [polypeptide binding]; other site 941193001466 GSH binding site (G-site) [chemical binding]; other site 941193001467 dimer interface [polypeptide binding]; other site 941193001468 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 941193001469 N-terminal domain interface [polypeptide binding]; other site 941193001470 dimer interface [polypeptide binding]; other site 941193001471 substrate binding pocket (H-site) [chemical binding]; other site 941193001472 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 941193001473 CoenzymeA binding site [chemical binding]; other site 941193001474 subunit interaction site [polypeptide binding]; other site 941193001475 PHB binding site; other site 941193001476 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193001477 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193001478 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 941193001479 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 941193001480 Na binding site [ion binding]; other site 941193001481 putative substrate binding site [chemical binding]; other site 941193001482 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193001483 The C-terminal substrate biniding domain of an uncharacterized LysR-like transcriptional regulator Pa0477 related to DntR, contains the type 2 periplasmic binding fold; Region: PBP2_Pa0477; cd08468 941193001484 putative substrate binding pocket [chemical binding]; other site 941193001485 dimerization interface [polypeptide binding]; other site 941193001486 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 941193001487 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193001488 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193001489 dimerization interface [polypeptide binding]; other site 941193001490 LysR substrate binding domain; Region: LysR_substrate; pfam03466 941193001491 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 941193001492 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 941193001493 active site 941193001494 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 941193001495 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941193001496 Coenzyme A binding pocket [chemical binding]; other site 941193001497 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 941193001498 ACT domain; Region: ACT_6; pfam13740 941193001499 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 941193001500 Predicted permeases [General function prediction only]; Region: RarD; COG2962 941193001501 EamA-like transporter family; Region: EamA; pfam00892 941193001502 serine/threonine protein kinase; Provisional; Region: PRK11768 941193001503 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 941193001504 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 941193001505 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 941193001506 TOBE domain; Region: TOBE; cl01440 941193001507 TOBE domain; Region: TOBE; cl01440 941193001508 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574 941193001509 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 941193001510 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941193001511 active site 941193001512 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193001513 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193001514 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 941193001515 putative substrate binding pocket [chemical binding]; other site 941193001516 dimerization interface [polypeptide binding]; other site 941193001517 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_2; cd11664 941193001518 putative active site [active] 941193001519 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 941193001520 carboxyltransferase (CT) interaction site; other site 941193001521 biotinylation site [posttranslational modification]; other site 941193001522 acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833 941193001523 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 941193001524 ATP-grasp domain; Region: ATP-grasp_4; cl17255 941193001525 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 941193001526 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 941193001527 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 941193001528 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 941193001529 Fimbrial protein; Region: Fimbrial; pfam00419 941193001530 Fimbrial protein; Region: Fimbrial; pfam00419 941193001531 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 941193001532 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 941193001533 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 941193001534 biotin synthase; Provisional; Region: PRK15108 941193001535 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941193001536 FeS/SAM binding site; other site 941193001537 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 941193001538 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 941193001539 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 941193001540 substrate-cofactor binding pocket; other site 941193001541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193001542 catalytic residue [active] 941193001543 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 941193001544 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 941193001545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193001546 S-adenosylmethionine binding site [chemical binding]; other site 941193001547 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 941193001548 AAA domain; Region: AAA_26; pfam13500 941193001549 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 941193001550 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 941193001551 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193001552 active site 941193001553 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 941193001554 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 941193001555 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 941193001556 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193001557 active site 941193001558 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 941193001559 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 941193001560 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 941193001561 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193001562 active site 941193001563 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 941193001564 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 941193001565 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 941193001566 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 941193001567 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 941193001568 structural tetrad; other site 941193001569 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 941193001570 active site 941193001571 SAM binding site [chemical binding]; other site 941193001572 homodimer interface [polypeptide binding]; other site 941193001573 heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051 941193001574 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941193001575 FeS/SAM binding site; other site 941193001576 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941193001577 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941193001578 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941193001579 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941193001580 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 941193001581 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 941193001582 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 941193001583 Cytochrome c551/c552 [Energy production and conversion]; Region: COG4654 941193001584 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 941193001585 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 941193001586 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 941193001587 MoxR-like ATPases [General function prediction only]; Region: COG0714 941193001588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193001589 Walker A motif; other site 941193001590 ATP binding site [chemical binding]; other site 941193001591 Walker B motif; other site 941193001592 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 941193001593 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 941193001594 Subunit I/III interface [polypeptide binding]; other site 941193001595 Cytochrome c; Region: Cytochrom_C; pfam00034 941193001596 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 941193001597 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 941193001598 Low-spin heme binding site [chemical binding]; other site 941193001599 D-pathway; other site 941193001600 Putative water exit pathway; other site 941193001601 Binuclear center (active site) [active] 941193001602 K-pathway; other site 941193001603 Putative proton exit pathway; other site 941193001604 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 941193001605 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 941193001606 metal ion-dependent adhesion site (MIDAS); other site 941193001607 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 941193001608 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 941193001609 ligand binding site [chemical binding]; other site 941193001610 flexible hinge region; other site 941193001611 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 941193001612 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193001613 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193001614 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941193001615 dimerization interface [polypeptide binding]; other site 941193001616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 941193001617 MOSC domain; Region: MOSC; pfam03473 941193001618 3-alpha domain; Region: 3-alpha; pfam03475 941193001619 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 941193001620 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941193001621 inhibitor-cofactor binding pocket; inhibition site 941193001622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193001623 catalytic residue [active] 941193001624 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 941193001625 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 941193001626 catalytic triad [active] 941193001627 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 941193001628 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193001629 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 941193001630 putative active site [active] 941193001631 heme pocket [chemical binding]; other site 941193001632 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193001633 putative active site [active] 941193001634 heme pocket [chemical binding]; other site 941193001635 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941193001636 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193001637 DNA binding residues [nucleotide binding] 941193001638 dimerization interface [polypeptide binding]; other site 941193001639 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 941193001640 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 941193001641 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941193001642 non-specific DNA binding site [nucleotide binding]; other site 941193001643 salt bridge; other site 941193001644 sequence-specific DNA binding site [nucleotide binding]; other site 941193001645 Cupin domain; Region: Cupin_2; pfam07883 941193001646 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 941193001647 Repair protein; Region: Repair_PSII; pfam04536 941193001648 LemA family; Region: LemA; pfam04011 941193001649 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 941193001650 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 941193001651 EamA-like transporter family; Region: EamA; pfam00892 941193001652 Predicted membrane protein [Function unknown]; Region: COG3686 941193001653 Cytochrome c556 [Energy production and conversion]; Region: COG3909 941193001654 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 941193001655 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 941193001656 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 941193001657 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 941193001658 active site 941193001659 metal binding site [ion binding]; metal-binding site 941193001660 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 941193001661 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 941193001662 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 941193001663 FAD binding pocket [chemical binding]; other site 941193001664 FAD binding motif [chemical binding]; other site 941193001665 phosphate binding motif [ion binding]; other site 941193001666 beta-alpha-beta structure motif; other site 941193001667 NAD binding pocket [chemical binding]; other site 941193001668 S-adenosylmethionine synthetase; Validated; Region: PRK05250 941193001669 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 941193001670 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 941193001671 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 941193001672 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941193001673 putative DNA binding site [nucleotide binding]; other site 941193001674 dimerization interface [polypeptide binding]; other site 941193001675 putative Zn2+ binding site [ion binding]; other site 941193001676 Methyltransferase domain; Region: Methyltransf_23; pfam13489 941193001677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193001678 S-adenosylmethionine binding site [chemical binding]; other site 941193001679 transketolase; Reviewed; Region: PRK12753 941193001680 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 941193001681 TPP-binding site [chemical binding]; other site 941193001682 dimer interface [polypeptide binding]; other site 941193001683 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 941193001684 PYR/PP interface [polypeptide binding]; other site 941193001685 dimer interface [polypeptide binding]; other site 941193001686 TPP binding site [chemical binding]; other site 941193001687 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 941193001688 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 941193001689 erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532 941193001690 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 941193001691 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 941193001692 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 941193001693 Phosphoglycerate kinase; Region: PGK; pfam00162 941193001694 substrate binding site [chemical binding]; other site 941193001695 hinge regions; other site 941193001696 ADP binding site [chemical binding]; other site 941193001697 catalytic site [active] 941193001698 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 941193001699 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 941193001700 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 941193001701 intersubunit interface [polypeptide binding]; other site 941193001702 active site 941193001703 zinc binding site [ion binding]; other site 941193001704 Na+ binding site [ion binding]; other site 941193001705 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 941193001706 SnoaL-like domain; Region: SnoaL_3; pfam13474 941193001707 Methyltransferase domain; Region: Methyltransf_31; pfam13847 941193001708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193001709 S-adenosylmethionine binding site [chemical binding]; other site 941193001710 Predicted flavoproteins [General function prediction only]; Region: COG2081 941193001711 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 941193001712 hydroxyglutarate oxidase; Provisional; Region: PRK11728 941193001713 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 941193001714 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 941193001715 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941193001716 motif II; other site 941193001717 Protein of unknown function (DUF805); Region: DUF805; pfam05656 941193001718 Cupin; Region: Cupin_6; pfam12852 941193001719 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941193001720 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193001721 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 941193001722 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 941193001723 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 941193001724 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 941193001725 Peptidase M60-like family; Region: M60-like; pfam13402 941193001726 Nuclease-related domain; Region: NERD; pfam08378 941193001727 Fic family protein [Function unknown]; Region: COG3177 941193001728 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 941193001729 Fic/DOC family; Region: Fic; pfam02661 941193001730 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941193001731 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193001732 substrate binding pocket [chemical binding]; other site 941193001733 membrane-bound complex binding site; other site 941193001734 hinge residues; other site 941193001735 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 941193001736 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193001737 putative active site [active] 941193001738 heme pocket [chemical binding]; other site 941193001739 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193001740 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 941193001741 putative active site [active] 941193001742 heme pocket [chemical binding]; other site 941193001743 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193001744 putative active site [active] 941193001745 heme pocket [chemical binding]; other site 941193001746 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193001747 putative active site [active] 941193001748 heme pocket [chemical binding]; other site 941193001749 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193001750 metal binding site [ion binding]; metal-binding site 941193001751 active site 941193001752 I-site; other site 941193001753 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941193001754 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 941193001755 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 941193001756 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 941193001757 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 941193001758 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941193001759 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 941193001760 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941193001761 DNA binding residues [nucleotide binding] 941193001762 DNA primase, catalytic core; Region: dnaG; TIGR01391 941193001763 CHC2 zinc finger; Region: zf-CHC2; pfam01807 941193001764 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 941193001765 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 941193001766 active site 941193001767 metal binding site [ion binding]; metal-binding site 941193001768 interdomain interaction site; other site 941193001769 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 941193001770 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 941193001771 Yqey-like protein; Region: YqeY; pfam09424 941193001772 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 941193001773 UGMP family protein; Validated; Region: PRK09604 941193001774 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 941193001775 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 941193001776 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 941193001777 homooctamer interface [polypeptide binding]; other site 941193001778 active site 941193001779 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 941193001780 catalytic center binding site [active] 941193001781 ATP binding site [chemical binding]; other site 941193001782 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 941193001783 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 941193001784 active site 941193001785 NTP binding site [chemical binding]; other site 941193001786 metal binding triad [ion binding]; metal-binding site 941193001787 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 941193001788 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941193001789 Zn2+ binding site [ion binding]; other site 941193001790 Mg2+ binding site [ion binding]; other site 941193001791 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 941193001792 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 941193001793 SpoVR family protein; Provisional; Region: PRK11767 941193001794 hypothetical protein; Provisional; Region: PRK05325 941193001795 PrkA family serine protein kinase; Provisional; Region: PRK15455 941193001796 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 941193001797 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 941193001798 active site residue [active] 941193001799 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 941193001800 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 941193001801 active site 941193001802 metal binding site [ion binding]; metal-binding site 941193001803 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 941193001804 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 941193001805 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 941193001806 S-adenosylmethionine binding site [chemical binding]; other site 941193001807 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 941193001808 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 941193001809 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 941193001810 SurA N-terminal domain; Region: SurA_N; pfam09312 941193001811 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 941193001812 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 941193001813 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 941193001814 OstA-like protein; Region: OstA; cl00844 941193001815 Organic solvent tolerance protein; Region: OstA_C; pfam04453 941193001816 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 941193001817 Phosphotransferase enzyme family; Region: APH; pfam01636 941193001818 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 941193001819 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 941193001820 Substrate binding site; other site 941193001821 metal-binding site 941193001822 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 941193001823 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 941193001824 putative metal binding site [ion binding]; other site 941193001825 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 941193001826 HSP70 interaction site [polypeptide binding]; other site 941193001827 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 941193001828 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193001829 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941193001830 substrate binding pocket [chemical binding]; other site 941193001831 membrane-bound complex binding site; other site 941193001832 hinge residues; other site 941193001833 PAS domain S-box; Region: sensory_box; TIGR00229 941193001834 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193001835 putative active site [active] 941193001836 heme pocket [chemical binding]; other site 941193001837 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193001838 PAS fold; Region: PAS_3; pfam08447 941193001839 putative active site [active] 941193001840 heme pocket [chemical binding]; other site 941193001841 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 941193001842 Histidine kinase; Region: HisKA_3; pfam07730 941193001843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193001844 ATP binding site [chemical binding]; other site 941193001845 Mg2+ binding site [ion binding]; other site 941193001846 G-X-G motif; other site 941193001847 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941193001848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193001849 active site 941193001850 phosphorylation site [posttranslational modification] 941193001851 intermolecular recognition site; other site 941193001852 dimerization interface [polypeptide binding]; other site 941193001853 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193001854 DNA binding residues [nucleotide binding] 941193001855 dimerization interface [polypeptide binding]; other site 941193001856 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 941193001857 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941193001858 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 941193001859 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 941193001860 Walker A/P-loop; other site 941193001861 ATP binding site [chemical binding]; other site 941193001862 Q-loop/lid; other site 941193001863 ABC transporter signature motif; other site 941193001864 Walker B; other site 941193001865 D-loop; other site 941193001866 H-loop/switch region; other site 941193001867 Poxvirus L5 protein family; Region: Pox_L5; cl17406 941193001868 TOBE domain; Region: TOBE_2; pfam08402 941193001869 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 941193001870 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941193001871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193001872 dimer interface [polypeptide binding]; other site 941193001873 conserved gate region; other site 941193001874 putative PBP binding loops; other site 941193001875 ABC-ATPase subunit interface; other site 941193001876 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 941193001877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193001878 dimer interface [polypeptide binding]; other site 941193001879 conserved gate region; other site 941193001880 putative PBP binding loops; other site 941193001881 ABC-ATPase subunit interface; other site 941193001882 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 941193001883 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 941193001884 substrate binding site [chemical binding]; other site 941193001885 hexamer interface [polypeptide binding]; other site 941193001886 metal binding site [ion binding]; metal-binding site 941193001887 phosphoglycolate phosphatase; Provisional; Region: PRK13223 941193001888 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941193001889 motif II; other site 941193001890 anthranilate synthase component I; Provisional; Region: PRK13565 941193001891 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 941193001892 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 941193001893 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 941193001894 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941193001895 non-specific DNA binding site [nucleotide binding]; other site 941193001896 Predicted transcriptional regulator [Transcription]; Region: COG2932 941193001897 salt bridge; other site 941193001898 sequence-specific DNA binding site [nucleotide binding]; other site 941193001899 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 941193001900 Catalytic site [active] 941193001901 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 941193001902 Predicted chitinase [General function prediction only]; Region: COG3179 941193001903 catalytic residue [active] 941193001904 Phage-related minor tail protein [Function unknown]; Region: COG5281 941193001905 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 941193001906 Phage-related minor tail protein [Function unknown]; Region: COG5281 941193001907 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 941193001908 Phage-related protein [Function unknown]; Region: COG4718 941193001909 Phage-related protein [Function unknown]; Region: gp18; COG4672 941193001910 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 941193001911 MPN+ (JAMM) motif; other site 941193001912 Zinc-binding site [ion binding]; other site 941193001913 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 941193001914 NlpC/P60 family; Region: NLPC_P60; pfam00877 941193001915 Phage-related protein, tail component [Function unknown]; Region: COG4723 941193001916 Phage-related protein, tail component [Function unknown]; Region: COG4733 941193001917 Putative phage tail protein; Region: Phage-tail_3; pfam13550 941193001918 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 941193001919 Interdomain contacts; other site 941193001920 Cytokine receptor motif; other site 941193001921 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 941193001922 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 941193001923 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 941193001924 glutamine binding [chemical binding]; other site 941193001925 catalytic triad [active] 941193001926 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 941193001927 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 941193001928 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 941193001929 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 941193001930 active site 941193001931 ribulose/triose binding site [chemical binding]; other site 941193001932 phosphate binding site [ion binding]; other site 941193001933 substrate (anthranilate) binding pocket [chemical binding]; other site 941193001934 product (indole) binding pocket [chemical binding]; other site 941193001935 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 941193001936 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 941193001937 ligand binding site [chemical binding]; other site 941193001938 flexible hinge region; other site 941193001939 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 941193001940 putative switch regulator; other site 941193001941 non-specific DNA interactions [nucleotide binding]; other site 941193001942 DNA binding site [nucleotide binding] 941193001943 sequence specific DNA binding site [nucleotide binding]; other site 941193001944 putative cAMP binding site [chemical binding]; other site 941193001945 OsmC-like protein; Region: OsmC; cl00767 941193001946 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 941193001947 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 941193001948 diiron binding motif [ion binding]; other site 941193001949 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 941193001950 nucleotide binding site/active site [active] 941193001951 HIT family signature motif; other site 941193001952 catalytic residue [active] 941193001953 Ycf46; Provisional; Region: ycf46; CHL00195 941193001954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193001955 Walker A motif; other site 941193001956 ATP binding site [chemical binding]; other site 941193001957 Walker B motif; other site 941193001958 arginine finger; other site 941193001959 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 941193001960 classical (c) SDRs; Region: SDR_c; cd05233 941193001961 NAD(P) binding site [chemical binding]; other site 941193001962 active site 941193001963 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 941193001964 Predicted membrane protein [Function unknown]; Region: COG3152 941193001965 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 941193001966 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 941193001967 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 941193001968 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 941193001969 FMN binding site [chemical binding]; other site 941193001970 substrate binding site [chemical binding]; other site 941193001971 putative catalytic residue [active] 941193001972 Predicted membrane protein [Function unknown]; Region: COG1981 941193001973 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 941193001974 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 941193001975 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 941193001976 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 941193001977 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 941193001978 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 941193001979 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 941193001980 Peptidase family M23; Region: Peptidase_M23; pfam01551 941193001981 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 941193001982 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 941193001983 active site 941193001984 HIGH motif; other site 941193001985 dimer interface [polypeptide binding]; other site 941193001986 KMSKS motif; other site 941193001987 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 941193001988 Biotin operon repressor [Transcription]; Region: BirA; COG1654 941193001989 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 941193001990 pantothenate kinase; Reviewed; Region: PRK13322 941193001991 Sporulation related domain; Region: SPOR; pfam05036 941193001992 Sporulation related domain; Region: SPOR; pfam05036 941193001993 Sporulation related domain; Region: SPOR; cl10051 941193001994 elongation factor Tu; Reviewed; Region: PRK00049 941193001995 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 941193001996 G1 box; other site 941193001997 GEF interaction site [polypeptide binding]; other site 941193001998 GTP/Mg2+ binding site [chemical binding]; other site 941193001999 Switch I region; other site 941193002000 G2 box; other site 941193002001 G3 box; other site 941193002002 Switch II region; other site 941193002003 G4 box; other site 941193002004 G5 box; other site 941193002005 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 941193002006 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 941193002007 Antibiotic Binding Site [chemical binding]; other site 941193002008 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 941193002009 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 941193002010 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 941193002011 putative homodimer interface [polypeptide binding]; other site 941193002012 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 941193002013 heterodimer interface [polypeptide binding]; other site 941193002014 homodimer interface [polypeptide binding]; other site 941193002015 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 941193002016 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 941193002017 23S rRNA interface [nucleotide binding]; other site 941193002018 L7/L12 interface [polypeptide binding]; other site 941193002019 putative thiostrepton binding site; other site 941193002020 L25 interface [polypeptide binding]; other site 941193002021 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 941193002022 mRNA/rRNA interface [nucleotide binding]; other site 941193002023 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 941193002024 23S rRNA interface [nucleotide binding]; other site 941193002025 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 941193002026 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 941193002027 core dimer interface [polypeptide binding]; other site 941193002028 peripheral dimer interface [polypeptide binding]; other site 941193002029 L10 interface [polypeptide binding]; other site 941193002030 L11 interface [polypeptide binding]; other site 941193002031 putative EF-Tu interaction site [polypeptide binding]; other site 941193002032 putative EF-G interaction site [polypeptide binding]; other site 941193002033 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 941193002034 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 941193002035 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 941193002036 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 941193002037 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 941193002038 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 941193002039 RPB3 interaction site [polypeptide binding]; other site 941193002040 RPB1 interaction site [polypeptide binding]; other site 941193002041 RPB11 interaction site [polypeptide binding]; other site 941193002042 RPB10 interaction site [polypeptide binding]; other site 941193002043 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 941193002044 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 941193002045 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 941193002046 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 941193002047 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 941193002048 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 941193002049 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 941193002050 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 941193002051 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 941193002052 DNA binding site [nucleotide binding] 941193002053 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 941193002054 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 941193002055 S17 interaction site [polypeptide binding]; other site 941193002056 S8 interaction site; other site 941193002057 16S rRNA interaction site [nucleotide binding]; other site 941193002058 streptomycin interaction site [chemical binding]; other site 941193002059 23S rRNA interaction site [nucleotide binding]; other site 941193002060 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 941193002061 30S ribosomal protein S7; Validated; Region: PRK05302 941193002062 elongation factor G; Reviewed; Region: PRK00007 941193002063 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 941193002064 G1 box; other site 941193002065 putative GEF interaction site [polypeptide binding]; other site 941193002066 GTP/Mg2+ binding site [chemical binding]; other site 941193002067 Switch I region; other site 941193002068 G2 box; other site 941193002069 G3 box; other site 941193002070 Switch II region; other site 941193002071 G4 box; other site 941193002072 G5 box; other site 941193002073 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 941193002074 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 941193002075 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 941193002076 elongation factor Tu; Reviewed; Region: PRK00049 941193002077 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 941193002078 G1 box; other site 941193002079 GEF interaction site [polypeptide binding]; other site 941193002080 GTP/Mg2+ binding site [chemical binding]; other site 941193002081 Switch I region; other site 941193002082 G2 box; other site 941193002083 G3 box; other site 941193002084 Switch II region; other site 941193002085 G4 box; other site 941193002086 G5 box; other site 941193002087 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 941193002088 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 941193002089 Antibiotic Binding Site [chemical binding]; other site 941193002090 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 941193002091 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 941193002092 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 941193002093 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 941193002094 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 941193002095 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 941193002096 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 941193002097 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 941193002098 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 941193002099 protein-rRNA interface [nucleotide binding]; other site 941193002100 putative translocon binding site; other site 941193002101 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 941193002102 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 941193002103 G-X-X-G motif; other site 941193002104 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 941193002105 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 941193002106 23S rRNA interface [nucleotide binding]; other site 941193002107 5S rRNA interface [nucleotide binding]; other site 941193002108 putative antibiotic binding site [chemical binding]; other site 941193002109 L25 interface [polypeptide binding]; other site 941193002110 L27 interface [polypeptide binding]; other site 941193002111 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 941193002112 23S rRNA interface [nucleotide binding]; other site 941193002113 putative translocon interaction site; other site 941193002114 signal recognition particle (SRP54) interaction site; other site 941193002115 L23 interface [polypeptide binding]; other site 941193002116 trigger factor interaction site; other site 941193002117 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 941193002118 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 941193002119 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 941193002120 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 941193002121 RNA binding site [nucleotide binding]; other site 941193002122 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 941193002123 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 941193002124 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 941193002125 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 941193002126 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 941193002127 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 941193002128 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 941193002129 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 941193002130 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 941193002131 5S rRNA interface [nucleotide binding]; other site 941193002132 23S rRNA interface [nucleotide binding]; other site 941193002133 L5 interface [polypeptide binding]; other site 941193002134 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 941193002135 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 941193002136 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 941193002137 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 941193002138 23S rRNA binding site [nucleotide binding]; other site 941193002139 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 941193002140 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 941193002141 SecY translocase; Region: SecY; pfam00344 941193002142 Ribosomal protein L36 [Translation, ribosomal structure and biogenesis]; Region: RpmJ; COG0257 941193002143 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 941193002144 30S ribosomal protein S13; Region: bact_S13; TIGR03631 941193002145 30S ribosomal protein S11; Validated; Region: PRK05309 941193002146 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 941193002147 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 941193002148 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941193002149 RNA binding surface [nucleotide binding]; other site 941193002150 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 941193002151 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 941193002152 alphaNTD homodimer interface [polypeptide binding]; other site 941193002153 alphaNTD - beta interaction site [polypeptide binding]; other site 941193002154 alphaNTD - beta' interaction site [polypeptide binding]; other site 941193002155 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 941193002156 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 941193002157 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 941193002158 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 941193002159 tetramer interface [polypeptide binding]; other site 941193002160 heme binding pocket [chemical binding]; other site 941193002161 NADPH binding site [chemical binding]; other site 941193002162 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 941193002163 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 941193002164 heme binding site [chemical binding]; other site 941193002165 ferroxidase pore; other site 941193002166 ferroxidase diiron center [ion binding]; other site 941193002167 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 941193002168 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 941193002169 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 941193002170 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 941193002171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193002172 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941193002173 putative substrate translocation pore; other site 941193002174 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 941193002175 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 941193002176 dimer interface [polypeptide binding]; other site 941193002177 ssDNA binding site [nucleotide binding]; other site 941193002178 tetramer (dimer of dimers) interface [polypeptide binding]; other site 941193002179 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 941193002180 active site 941193002181 Int/Topo IB signature motif; other site 941193002182 DNA binding site [nucleotide binding] 941193002183 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 941193002184 active site 941193002185 catalytic residues [active] 941193002186 DNA binding site [nucleotide binding] 941193002187 Int/Topo IB signature motif; other site 941193002188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 941193002189 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 941193002190 DNA binding site [nucleotide binding] 941193002191 active site 941193002192 Int/Topo IB signature motif; other site 941193002193 catalytic residues [active] 941193002194 AAA domain; Region: AAA_23; pfam13476 941193002195 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193002196 Walker A/P-loop; other site 941193002197 ATP binding site [chemical binding]; other site 941193002198 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193002199 ABC transporter signature motif; other site 941193002200 Walker B; other site 941193002201 D-loop; other site 941193002202 H-loop/switch region; other site 941193002203 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 941193002204 DNA methylase; Region: N6_N4_Mtase; pfam01555 941193002205 DNA methylase; Region: N6_N4_Mtase; pfam01555 941193002206 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 941193002207 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 941193002208 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 941193002209 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 941193002210 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 941193002211 isochorismate synthases; Region: isochor_syn; TIGR00543 941193002212 isochorismate-pyruvate lyase; Reviewed; Region: PRK07075 941193002213 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 941193002214 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 941193002215 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 941193002216 acyl-activating enzyme (AAE) consensus motif; other site 941193002217 active site 941193002218 AMP binding site [chemical binding]; other site 941193002219 substrate binding site [chemical binding]; other site 941193002220 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941193002221 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193002222 Phosphopantetheine attachment site; Region: PP-binding; cl09936 941193002223 Condensation domain; Region: Condensation; pfam00668 941193002224 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 941193002225 Nonribosomal peptide synthase; Region: NRPS; pfam08415 941193002226 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 941193002227 acyl-activating enzyme (AAE) consensus motif; other site 941193002228 AMP binding site [chemical binding]; other site 941193002229 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 941193002230 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941193002231 Condensation domain; Region: Condensation; pfam00668 941193002232 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 941193002233 Nonribosomal peptide synthase; Region: NRPS; pfam08415 941193002234 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 941193002235 acyl-activating enzyme (AAE) consensus motif; other site 941193002236 AMP binding site [chemical binding]; other site 941193002237 Methyltransferase domain; Region: Methyltransf_12; pfam08242 941193002238 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 941193002239 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941193002240 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 941193002241 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 941193002242 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 941193002243 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 941193002244 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193002245 Walker A/P-loop; other site 941193002246 ATP binding site [chemical binding]; other site 941193002247 Q-loop/lid; other site 941193002248 ABC transporter signature motif; other site 941193002249 Walker B; other site 941193002250 D-loop; other site 941193002251 H-loop/switch region; other site 941193002252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193002253 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 941193002254 Walker A/P-loop; other site 941193002255 ATP binding site [chemical binding]; other site 941193002256 Q-loop/lid; other site 941193002257 ABC transporter signature motif; other site 941193002258 Walker B; other site 941193002259 D-loop; other site 941193002260 H-loop/switch region; other site 941193002261 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 941193002262 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193002263 N-terminal plug; other site 941193002264 ligand-binding site [chemical binding]; other site 941193002265 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 941193002266 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 941193002267 Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000 941193002268 hypothetical protein; Provisional; Region: PRK07538 941193002269 hypothetical protein; Provisional; Region: PRK07236 941193002270 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 941193002271 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 941193002272 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 941193002273 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 941193002274 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 941193002275 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 941193002276 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 941193002277 Glutamine amidotransferase class-I; Region: GATase; pfam00117 941193002278 glutamine binding [chemical binding]; other site 941193002279 catalytic triad [active] 941193002280 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 941193002281 hydrophobic substrate binding pocket; other site 941193002282 Isochorismatase family; Region: Isochorismatase; pfam00857 941193002283 active site 941193002284 conserved cis-peptide bond; other site 941193002285 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 941193002286 Phenazine biosynthesis protein A/B; Region: PHZA_PHZB; pfam03284 941193002287 Phenazine biosynthesis protein A/B; Region: PHZA_PHZB; pfam03284 941193002288 O-methyltransferase; Region: Methyltransf_2; pfam00891 941193002289 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 941193002290 multidrug efflux protein; Reviewed; Region: PRK09579 941193002291 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 941193002292 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193002293 Predicted membrane protein [Function unknown]; Region: COG2259 941193002294 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 941193002295 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193002296 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193002297 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193002298 dimerization interface [polypeptide binding]; other site 941193002299 Nitronate monooxygenase; Region: NMO; pfam03060 941193002300 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 941193002301 FMN binding site [chemical binding]; other site 941193002302 substrate binding site [chemical binding]; other site 941193002303 putative catalytic residue [active] 941193002304 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 941193002305 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 941193002306 ATP-grasp domain; Region: ATP-grasp_4; cl17255 941193002307 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941193002308 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 941193002309 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 941193002310 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193002311 active site 941193002312 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 941193002313 acyl-CoA synthetase; Validated; Region: PRK08162 941193002314 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 941193002315 acyl-activating enzyme (AAE) consensus motif; other site 941193002316 putative active site [active] 941193002317 AMP binding site [chemical binding]; other site 941193002318 putative CoA binding site [chemical binding]; other site 941193002319 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 941193002320 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193002321 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 941193002322 putative active site [active] 941193002323 heme pocket [chemical binding]; other site 941193002324 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 941193002325 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193002326 putative active site [active] 941193002327 heme pocket [chemical binding]; other site 941193002328 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193002329 dimer interface [polypeptide binding]; other site 941193002330 phosphorylation site [posttranslational modification] 941193002331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193002332 ATP binding site [chemical binding]; other site 941193002333 Mg2+ binding site [ion binding]; other site 941193002334 G-X-G motif; other site 941193002335 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 941193002336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193002337 active site 941193002338 phosphorylation site [posttranslational modification] 941193002339 intermolecular recognition site; other site 941193002340 dimerization interface [polypeptide binding]; other site 941193002341 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193002342 DNA binding residues [nucleotide binding] 941193002343 dimerization interface [polypeptide binding]; other site 941193002344 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941193002345 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193002346 substrate binding pocket [chemical binding]; other site 941193002347 membrane-bound complex binding site; other site 941193002348 hinge residues; other site 941193002349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193002350 dimer interface [polypeptide binding]; other site 941193002351 conserved gate region; other site 941193002352 putative PBP binding loops; other site 941193002353 ABC-ATPase subunit interface; other site 941193002354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193002355 dimer interface [polypeptide binding]; other site 941193002356 conserved gate region; other site 941193002357 putative PBP binding loops; other site 941193002358 ABC-ATPase subunit interface; other site 941193002359 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 941193002360 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 941193002361 Walker A/P-loop; other site 941193002362 ATP binding site [chemical binding]; other site 941193002363 Q-loop/lid; other site 941193002364 ABC transporter signature motif; other site 941193002365 Walker B; other site 941193002366 D-loop; other site 941193002367 H-loop/switch region; other site 941193002368 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 941193002369 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 941193002370 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 941193002371 putative monooxygenase; Reviewed; Region: PRK07045 941193002372 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 941193002373 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 941193002374 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 941193002375 NAD(P) binding site [chemical binding]; other site 941193002376 catalytic residues [active] 941193002377 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 941193002378 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 941193002379 inhibitor site; inhibition site 941193002380 active site 941193002381 dimer interface [polypeptide binding]; other site 941193002382 catalytic residue [active] 941193002383 benzoate transport; Region: 2A0115; TIGR00895 941193002384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193002385 putative substrate translocation pore; other site 941193002386 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 941193002387 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 941193002388 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 941193002389 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193002390 DNA-binding site [nucleotide binding]; DNA binding site 941193002391 FCD domain; Region: FCD; pfam07729 941193002392 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 941193002393 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 941193002394 conserved cys residue [active] 941193002395 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193002396 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941193002397 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 941193002398 active site 941193002399 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 941193002400 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 941193002401 B3/4 domain; Region: B3_4; pfam03483 941193002402 acetolactate synthase; Reviewed; Region: PRK08322 941193002403 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 941193002404 PYR/PP interface [polypeptide binding]; other site 941193002405 dimer interface [polypeptide binding]; other site 941193002406 TPP binding site [chemical binding]; other site 941193002407 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 941193002408 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 941193002409 TPP-binding site [chemical binding]; other site 941193002410 dimer interface [polypeptide binding]; other site 941193002411 outer membrane porin, OprD family; Region: OprD; pfam03573 941193002412 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 941193002413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193002414 S-adenosylmethionine binding site [chemical binding]; other site 941193002415 Uncharacterized conserved protein [Function unknown]; Region: COG3791 941193002416 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 941193002417 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 941193002418 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193002419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193002420 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 941193002421 putative effector binding pocket; other site 941193002422 putative dimerization interface [polypeptide binding]; other site 941193002423 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 941193002424 homotrimer interaction site [polypeptide binding]; other site 941193002425 putative active site [active] 941193002426 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 941193002427 putative catalytic site [active] 941193002428 putative phosphate binding site [ion binding]; other site 941193002429 active site 941193002430 metal binding site A [ion binding]; metal-binding site 941193002431 DNA binding site [nucleotide binding] 941193002432 putative AP binding site [nucleotide binding]; other site 941193002433 putative metal binding site B [ion binding]; other site 941193002434 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 941193002435 intracellular protease, PfpI family; Region: PfpI; TIGR01382 941193002436 proposed catalytic triad [active] 941193002437 conserved cys residue [active] 941193002438 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 941193002439 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 941193002440 Predicted transcriptional regulator [Transcription]; Region: COG1959 941193002441 Transcriptional regulator; Region: Rrf2; pfam02082 941193002442 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 941193002443 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193002444 N-terminal plug; other site 941193002445 ligand-binding site [chemical binding]; other site 941193002446 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 941193002447 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 941193002448 active site 941193002449 catalytic tetrad [active] 941193002450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941193002451 Coenzyme A binding pocket [chemical binding]; other site 941193002452 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 941193002453 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193002454 DNA-binding site [nucleotide binding]; DNA binding site 941193002455 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941193002456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193002457 homodimer interface [polypeptide binding]; other site 941193002458 catalytic residue [active] 941193002459 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 941193002460 putative active site pocket [active] 941193002461 dimerization interface [polypeptide binding]; other site 941193002462 putative catalytic residue [active] 941193002463 amidase; Validated; Region: PRK06565 941193002464 Amidase; Region: Amidase; cl11426 941193002465 short chain dehydrogenase; Provisional; Region: PRK07577 941193002466 classical (c) SDRs; Region: SDR_c; cd05233 941193002467 NAD(P) binding site [chemical binding]; other site 941193002468 active site 941193002469 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 941193002470 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941193002471 ABC-ATPase subunit interface; other site 941193002472 dimer interface [polypeptide binding]; other site 941193002473 putative PBP binding regions; other site 941193002474 FecCD transport family; Region: FecCD; pfam01032 941193002475 ABC-ATPase subunit interface; other site 941193002476 dimer interface [polypeptide binding]; other site 941193002477 putative PBP binding regions; other site 941193002478 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 941193002479 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 941193002480 siderophore binding site; other site 941193002481 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 941193002482 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 941193002483 Walker A/P-loop; other site 941193002484 ATP binding site [chemical binding]; other site 941193002485 Q-loop/lid; other site 941193002486 ABC transporter signature motif; other site 941193002487 Walker B; other site 941193002488 D-loop; other site 941193002489 H-loop/switch region; other site 941193002490 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 941193002491 Transcriptional regulator [Transcription]; Region: IclR; COG1414 941193002492 Bacterial transcriptional regulator; Region: IclR; pfam01614 941193002493 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 941193002494 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 941193002495 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 941193002496 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 941193002497 active site 941193002498 non-prolyl cis peptide bond; other site 941193002499 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 941193002500 Bacterial SH3 domain; Region: SH3_3; pfam08239 941193002501 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 941193002502 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 941193002503 putative NAD(P) binding site [chemical binding]; other site 941193002504 catalytic Zn binding site [ion binding]; other site 941193002505 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 941193002506 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 941193002507 E3 interaction surface; other site 941193002508 lipoyl attachment site [posttranslational modification]; other site 941193002509 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 941193002510 nucleophilic elbow; other site 941193002511 catalytic triad; other site 941193002512 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 941193002513 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 941193002514 alpha subunit interface [polypeptide binding]; other site 941193002515 TPP binding site [chemical binding]; other site 941193002516 heterodimer interface [polypeptide binding]; other site 941193002517 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 941193002518 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 941193002519 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 941193002520 tetramer interface [polypeptide binding]; other site 941193002521 TPP-binding site [chemical binding]; other site 941193002522 heterodimer interface [polypeptide binding]; other site 941193002523 phosphorylation loop region [posttranslational modification] 941193002524 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 941193002525 ATP-NAD kinase; Region: NAD_kinase; pfam01513 941193002526 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 941193002527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193002528 NAD(P) binding site [chemical binding]; other site 941193002529 active site 941193002530 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 941193002531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193002532 Walker A motif; other site 941193002533 ATP binding site [chemical binding]; other site 941193002534 Walker B motif; other site 941193002535 arginine finger; other site 941193002536 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941193002537 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 941193002538 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193002539 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941193002540 putative effector binding pocket; other site 941193002541 dimerization interface [polypeptide binding]; other site 941193002542 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 941193002543 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 941193002544 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 941193002545 putative active site [active] 941193002546 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941193002547 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 941193002548 Walker A/P-loop; other site 941193002549 ATP binding site [chemical binding]; other site 941193002550 Q-loop/lid; other site 941193002551 ABC transporter signature motif; other site 941193002552 Walker B; other site 941193002553 D-loop; other site 941193002554 H-loop/switch region; other site 941193002555 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 941193002556 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193002557 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193002558 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 941193002559 FAD binding domain; Region: FAD_binding_4; pfam01565 941193002560 Cholesterol oxidase, substrate-binding; Region: Chol_subst-bind; pfam09129 941193002561 outer membrane porin, OprD family; Region: OprD; pfam03573 941193002562 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 941193002563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193002564 putative substrate translocation pore; other site 941193002565 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 941193002566 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941193002567 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 941193002568 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 941193002569 Low-spin heme binding site [chemical binding]; other site 941193002570 Putative water exit pathway; other site 941193002571 Binuclear center (active site) [active] 941193002572 Putative proton exit pathway; other site 941193002573 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 941193002574 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193002575 DNA-binding site [nucleotide binding]; DNA binding site 941193002576 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941193002577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193002578 homodimer interface [polypeptide binding]; other site 941193002579 catalytic residue [active] 941193002580 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 941193002581 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 941193002582 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 941193002583 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 941193002584 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 941193002585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 941193002586 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 941193002587 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 941193002588 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 941193002589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193002590 putative substrate translocation pore; other site 941193002591 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 941193002592 putative substrate binding pocket [chemical binding]; other site 941193002593 trimer interface [polypeptide binding]; other site 941193002594 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 941193002595 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 941193002596 putative active site [active] 941193002597 putative metal binding site [ion binding]; other site 941193002598 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 941193002599 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 941193002600 NAD binding site [chemical binding]; other site 941193002601 catalytic residues [active] 941193002602 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 941193002603 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 941193002604 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 941193002605 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 941193002606 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 941193002607 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 941193002608 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193002609 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 941193002610 Phosphotransferase enzyme family; Region: APH; pfam01636 941193002611 substrate binding site [chemical binding]; other site 941193002612 Predicted periplasmic protein [Function unknown]; Region: COG3904 941193002613 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 941193002614 GAF domain; Region: GAF; pfam01590 941193002615 Phytochrome region; Region: PHY; pfam00360 941193002616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193002617 dimer interface [polypeptide binding]; other site 941193002618 phosphorylation site [posttranslational modification] 941193002619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193002620 ATP binding site [chemical binding]; other site 941193002621 Mg2+ binding site [ion binding]; other site 941193002622 G-X-G motif; other site 941193002623 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 941193002624 heme binding pocket [chemical binding]; other site 941193002625 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 941193002626 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 941193002627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941193002628 Coenzyme A binding pocket [chemical binding]; other site 941193002629 putative arabinose transporter; Provisional; Region: PRK03545 941193002630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193002631 putative substrate translocation pore; other site 941193002632 CHASE domain; Region: CHASE; cl01369 941193002633 PAS domain S-box; Region: sensory_box; TIGR00229 941193002634 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193002635 putative active site [active] 941193002636 heme pocket [chemical binding]; other site 941193002637 PAS domain; Region: PAS_9; pfam13426 941193002638 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193002639 putative active site [active] 941193002640 heme pocket [chemical binding]; other site 941193002641 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193002642 PAS fold; Region: PAS_3; pfam08447 941193002643 putative active site [active] 941193002644 heme pocket [chemical binding]; other site 941193002645 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193002646 dimer interface [polypeptide binding]; other site 941193002647 phosphorylation site [posttranslational modification] 941193002648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193002649 ATP binding site [chemical binding]; other site 941193002650 Mg2+ binding site [ion binding]; other site 941193002651 G-X-G motif; other site 941193002652 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 941193002653 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193002654 active site 941193002655 phosphorylation site [posttranslational modification] 941193002656 intermolecular recognition site; other site 941193002657 dimerization interface [polypeptide binding]; other site 941193002658 Response regulator receiver domain; Region: Response_reg; pfam00072 941193002659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193002660 active site 941193002661 phosphorylation site [posttranslational modification] 941193002662 intermolecular recognition site; other site 941193002663 dimerization interface [polypeptide binding]; other site 941193002664 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 941193002665 putative binding surface; other site 941193002666 active site 941193002667 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 941193002668 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 941193002669 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 941193002670 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193002671 The C-terminal substrate-domain of LysR-type transcriptional regulators for beta-lactamase genes, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_beta_lactamase; cd08484 941193002672 putative dimerization interface [polypeptide binding]; other site 941193002673 putative substrate binding pocket [chemical binding]; other site 941193002674 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 941193002675 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 941193002676 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941193002677 Zn2+ binding site [ion binding]; other site 941193002678 Mg2+ binding site [ion binding]; other site 941193002679 SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate...; Region: SPARC_EC; cd00252 941193002680 EF-hand Ca2+ binding loops [ion binding]; other site 941193002681 FS-domain interface [polypeptide binding]; other site 941193002682 Protein of unknown function (DUF692); Region: DUF692; pfam05114 941193002683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3219 941193002684 DoxX; Region: DoxX; pfam07681 941193002685 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 941193002686 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941193002687 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 941193002688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193002689 ATP binding site [chemical binding]; other site 941193002690 Mg2+ binding site [ion binding]; other site 941193002691 G-X-G motif; other site 941193002692 osmolarity response regulator; Provisional; Region: ompR; PRK09468 941193002693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193002694 active site 941193002695 phosphorylation site [posttranslational modification] 941193002696 intermolecular recognition site; other site 941193002697 dimerization interface [polypeptide binding]; other site 941193002698 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193002699 DNA binding site [nucleotide binding] 941193002700 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 941193002701 choline dehydrogenase; Validated; Region: PRK02106 941193002702 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 941193002703 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 941193002704 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 941193002705 classical (c) SDRs; Region: SDR_c; cd05233 941193002706 NAD(P) binding site [chemical binding]; other site 941193002707 active site 941193002708 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 941193002709 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 941193002710 putative NAD(P) binding site [chemical binding]; other site 941193002711 catalytic Zn binding site [ion binding]; other site 941193002712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193002713 D-galactonate transporter; Region: 2A0114; TIGR00893 941193002714 putative substrate translocation pore; other site 941193002715 Cupin domain; Region: Cupin_2; pfam07883 941193002716 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941193002717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193002718 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 941193002719 CoenzymeA binding site [chemical binding]; other site 941193002720 subunit interaction site [polypeptide binding]; other site 941193002721 PHB binding site; other site 941193002722 Flavin Reductases; Region: FlaRed; cl00801 941193002723 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 941193002724 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 941193002725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3553 941193002726 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 941193002727 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193002728 NAD(P) binding site [chemical binding]; other site 941193002729 active site 941193002730 aminotransferase; Validated; Region: PRK07046 941193002731 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941193002732 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941193002733 catalytic residue [active] 941193002734 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 941193002735 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 941193002736 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 941193002737 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 941193002738 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 941193002739 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 941193002740 PapC N-terminal domain; Region: PapC_N; pfam13954 941193002741 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 941193002742 PapC C-terminal domain; Region: PapC_C; pfam13953 941193002743 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 941193002744 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 941193002745 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 941193002746 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 941193002747 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 941193002748 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 941193002749 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941193002750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193002751 active site 941193002752 phosphorylation site [posttranslational modification] 941193002753 intermolecular recognition site; other site 941193002754 dimerization interface [polypeptide binding]; other site 941193002755 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193002756 DNA binding residues [nucleotide binding] 941193002757 dimerization interface [polypeptide binding]; other site 941193002758 short chain dehydrogenase; Provisional; Region: PRK08177 941193002759 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 941193002760 NAD(P) binding site [chemical binding]; other site 941193002761 active site 941193002762 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 941193002763 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 941193002764 acyl-activating enzyme (AAE) consensus motif; other site 941193002765 AMP binding site [chemical binding]; other site 941193002766 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941193002767 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 941193002768 Male sterility protein; Region: NAD_binding_4; pfam07993 941193002769 NAD(P) binding site [chemical binding]; other site 941193002770 active site 941193002771 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941193002772 non-specific DNA binding site [nucleotide binding]; other site 941193002773 salt bridge; other site 941193002774 sequence-specific DNA binding site [nucleotide binding]; other site 941193002775 Methyltransferase domain; Region: Methyltransf_11; pfam08241 941193002776 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193002777 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941193002778 DNA binding residues [nucleotide binding] 941193002779 dimerization interface [polypeptide binding]; other site 941193002780 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 941193002781 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 941193002782 NAD(P) binding site [chemical binding]; other site 941193002783 catalytic residues [active] 941193002784 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 941193002785 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 941193002786 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 941193002787 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193002788 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 941193002789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193002790 NAD(P) binding site [chemical binding]; other site 941193002791 active site 941193002792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193002793 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 941193002794 NAD(P) binding site [chemical binding]; other site 941193002795 active site 941193002796 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 941193002797 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 941193002798 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 941193002799 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 941193002800 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 941193002801 FtsX-like permease family; Region: FtsX; pfam02687 941193002802 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 941193002803 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 941193002804 Walker A/P-loop; other site 941193002805 ATP binding site [chemical binding]; other site 941193002806 Q-loop/lid; other site 941193002807 ABC transporter signature motif; other site 941193002808 Walker B; other site 941193002809 D-loop; other site 941193002810 H-loop/switch region; other site 941193002811 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 941193002812 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 941193002813 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 941193002814 Predicted methyltransferase [General function prediction only]; Region: COG3897 941193002815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 941193002816 S-adenosylmethionine binding site [chemical binding]; other site 941193002817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 941193002818 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 941193002819 ATP cone domain; Region: ATP-cone; pfam03477 941193002820 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 941193002821 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 941193002822 catalytic motif [active] 941193002823 Zn binding site [ion binding]; other site 941193002824 RibD C-terminal domain; Region: RibD_C; cl17279 941193002825 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 941193002826 Lumazine binding domain; Region: Lum_binding; pfam00677 941193002827 Lumazine binding domain; Region: Lum_binding; pfam00677 941193002828 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 941193002829 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 941193002830 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 941193002831 dimerization interface [polypeptide binding]; other site 941193002832 active site 941193002833 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 941193002834 homopentamer interface [polypeptide binding]; other site 941193002835 active site 941193002836 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 941193002837 thiamine monophosphate kinase; Provisional; Region: PRK05731 941193002838 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 941193002839 ATP binding site [chemical binding]; other site 941193002840 dimerization interface [polypeptide binding]; other site 941193002841 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 941193002842 tetramer interfaces [polypeptide binding]; other site 941193002843 binuclear metal-binding site [ion binding]; other site 941193002844 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941193002845 Predicted aspartyl protease [General function prediction only]; Region: COG3577 941193002846 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 941193002847 catalytic motif [active] 941193002848 Catalytic residue [active] 941193002849 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 941193002850 dimerization interface [polypeptide binding]; other site 941193002851 active site 941193002852 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 941193002853 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 941193002854 cobalamin binding residues [chemical binding]; other site 941193002855 putative BtuC binding residues; other site 941193002856 dimer interface [polypeptide binding]; other site 941193002857 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 941193002858 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 941193002859 TPP-binding site; other site 941193002860 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 941193002861 PYR/PP interface [polypeptide binding]; other site 941193002862 dimer interface [polypeptide binding]; other site 941193002863 TPP binding site [chemical binding]; other site 941193002864 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 941193002865 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 941193002866 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 941193002867 substrate binding pocket [chemical binding]; other site 941193002868 chain length determination region; other site 941193002869 substrate-Mg2+ binding site; other site 941193002870 catalytic residues [active] 941193002871 aspartate-rich region 1; other site 941193002872 active site lid residues [active] 941193002873 aspartate-rich region 2; other site 941193002874 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 941193002875 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 941193002876 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 941193002877 putative active site pocket [active] 941193002878 metal binding site [ion binding]; metal-binding site 941193002879 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 941193002880 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 941193002881 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 941193002882 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 941193002883 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941193002884 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 941193002885 Walker A/P-loop; other site 941193002886 ATP binding site [chemical binding]; other site 941193002887 Q-loop/lid; other site 941193002888 ABC transporter signature motif; other site 941193002889 Walker B; other site 941193002890 D-loop; other site 941193002891 H-loop/switch region; other site 941193002892 CHASE2 domain; Region: CHASE2; pfam05226 941193002893 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 941193002894 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 941193002895 PAS domain; Region: PAS; smart00091 941193002896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193002897 dimer interface [polypeptide binding]; other site 941193002898 phosphorylation site [posttranslational modification] 941193002899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193002900 ATP binding site [chemical binding]; other site 941193002901 Mg2+ binding site [ion binding]; other site 941193002902 G-X-G motif; other site 941193002903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 941193002904 FecR protein; Region: FecR; pfam04773 941193002905 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 941193002906 amphipathic channel; other site 941193002907 Asn-Pro-Ala signature motifs; other site 941193002908 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941193002909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193002910 active site 941193002911 phosphorylation site [posttranslational modification] 941193002912 intermolecular recognition site; other site 941193002913 dimerization interface [polypeptide binding]; other site 941193002914 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193002915 DNA binding site [nucleotide binding] 941193002916 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 941193002917 dimer interface [polypeptide binding]; other site 941193002918 substrate binding site [chemical binding]; other site 941193002919 metal binding sites [ion binding]; metal-binding site 941193002920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3228 941193002921 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 941193002922 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 941193002923 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 941193002924 substrate binding site [chemical binding]; other site 941193002925 activation loop (A-loop); other site 941193002926 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941193002927 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193002928 substrate binding pocket [chemical binding]; other site 941193002929 membrane-bound complex binding site; other site 941193002930 hinge residues; other site 941193002931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941193002932 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 941193002933 Coenzyme A binding pocket [chemical binding]; other site 941193002934 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 941193002935 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 941193002936 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 941193002937 ethanolamine permease; Region: 2A0305; TIGR00908 941193002938 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 941193002939 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 941193002940 NAD(P) binding site [chemical binding]; other site 941193002941 catalytic residues [active] 941193002942 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 941193002943 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193002944 putative active site [active] 941193002945 heme pocket [chemical binding]; other site 941193002946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193002947 Walker A motif; other site 941193002948 ATP binding site [chemical binding]; other site 941193002949 Walker B motif; other site 941193002950 arginine finger; other site 941193002951 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941193002952 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 941193002953 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 941193002954 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941193002955 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 941193002956 aromatic acid decarboxylase; Validated; Region: PRK05920 941193002957 Flavoprotein; Region: Flavoprotein; pfam02441 941193002958 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5645 941193002959 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 941193002960 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 941193002961 NAD binding site [chemical binding]; other site 941193002962 active site 941193002963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 941193002964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 941193002965 MORN repeat; Region: MORN; cl14787 941193002966 Peptidase C13 family; Region: Peptidase_C13; pfam01650 941193002967 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 941193002968 putative active site [active] 941193002969 putative catalytic site [active] 941193002970 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 941193002971 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 941193002972 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 941193002973 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 941193002974 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 941193002975 active site 941193002976 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 941193002977 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 941193002978 active site 941193002979 DNA binding site [nucleotide binding] 941193002980 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 941193002981 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 941193002982 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 941193002983 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 941193002984 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 941193002985 putative catalytic cysteine [active] 941193002986 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 941193002987 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 941193002988 active site 941193002989 (T/H)XGH motif; other site 941193002990 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 941193002991 Uncharacterized conserved protein [Function unknown]; Region: COG1576 941193002992 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 941193002993 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 941193002994 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 941193002995 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 941193002996 Transglycosylase SLT domain; Region: SLT_2; pfam13406 941193002997 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 941193002998 N-acetyl-D-glucosamine binding site [chemical binding]; other site 941193002999 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 941193003000 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 941193003001 Sporulation related domain; Region: SPOR; pfam05036 941193003002 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 941193003003 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 941193003004 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 941193003005 hypothetical protein; Provisional; Region: PRK00341 941193003006 lipoate-protein ligase B; Provisional; Region: PRK14342 941193003007 lipoyl synthase; Provisional; Region: PRK05481 941193003008 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941193003009 FeS/SAM binding site; other site 941193003010 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193003011 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193003012 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193003013 dimerization interface [polypeptide binding]; other site 941193003014 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 941193003015 Transglycosylase SLT domain; Region: SLT_2; pfam13406 941193003016 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 941193003017 N-acetyl-D-glucosamine binding site [chemical binding]; other site 941193003018 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 941193003019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 941193003020 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 941193003021 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 941193003022 Rare lipoprotein B [Cell envelope biogenesis, outer membrane]; Region: RlpB; COG2980 941193003023 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 941193003024 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 941193003025 HIGH motif; other site 941193003026 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 941193003027 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 941193003028 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 941193003029 active site 941193003030 KMSKS motif; other site 941193003031 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 941193003032 tRNA binding surface [nucleotide binding]; other site 941193003033 Uncharacterized conserved protein [Function unknown]; Region: COG1434 941193003034 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 941193003035 putative active site [active] 941193003036 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 941193003037 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 941193003038 putative active site [active] 941193003039 catalytic triad [active] 941193003040 putative dimer interface [polypeptide binding]; other site 941193003041 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 941193003042 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 941193003043 Transporter associated domain; Region: CorC_HlyC; smart01091 941193003044 metal-binding heat shock protein; Provisional; Region: PRK00016 941193003045 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 941193003046 PhoH-like protein; Region: PhoH; pfam02562 941193003047 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 941193003048 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 941193003049 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941193003050 FeS/SAM binding site; other site 941193003051 TRAM domain; Region: TRAM; pfam01938 941193003052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4517 941193003053 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 941193003054 Sel1-like repeats; Region: SEL1; smart00671 941193003055 Sel1-like repeats; Region: SEL1; smart00671 941193003056 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 941193003057 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941193003058 inhibitor-cofactor binding pocket; inhibition site 941193003059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193003060 catalytic residue [active] 941193003061 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 941193003062 thiamine phosphate binding site [chemical binding]; other site 941193003063 active site 941193003064 pyrophosphate binding site [ion binding]; other site 941193003065 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 941193003066 substrate binding site [chemical binding]; other site 941193003067 dimer interface [polypeptide binding]; other site 941193003068 ATP binding site [chemical binding]; other site 941193003069 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 941193003070 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 941193003071 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941193003072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193003073 dimer interface [polypeptide binding]; other site 941193003074 phosphorylation site [posttranslational modification] 941193003075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193003076 ATP binding site [chemical binding]; other site 941193003077 Mg2+ binding site [ion binding]; other site 941193003078 G-X-G motif; other site 941193003079 Response regulator receiver domain; Region: Response_reg; pfam00072 941193003080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193003081 active site 941193003082 phosphorylation site [posttranslational modification] 941193003083 intermolecular recognition site; other site 941193003084 dimerization interface [polypeptide binding]; other site 941193003085 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193003086 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193003087 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 941193003088 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193003089 active site 941193003090 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 941193003091 CoenzymeA binding site [chemical binding]; other site 941193003092 subunit interaction site [polypeptide binding]; other site 941193003093 PHB binding site; other site 941193003094 AMP nucleosidase; Provisional; Region: PRK08292 941193003095 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 941193003096 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 941193003097 SEC-C motif; Region: SEC-C; pfam02810 941193003098 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 941193003099 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 941193003100 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 941193003101 pseudouridine synthase; Region: TIGR00093 941193003102 active site 941193003103 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 941193003104 heme-binding site [chemical binding]; other site 941193003105 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 941193003106 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941193003107 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941193003108 putative DNA binding site [nucleotide binding]; other site 941193003109 putative Zn2+ binding site [ion binding]; other site 941193003110 AsnC family; Region: AsnC_trans_reg; pfam01037 941193003111 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 941193003112 Cation efflux family; Region: Cation_efflux; cl00316 941193003113 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 941193003114 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941193003115 ATP binding site [chemical binding]; other site 941193003116 putative Mg++ binding site [ion binding]; other site 941193003117 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941193003118 nucleotide binding region [chemical binding]; other site 941193003119 ATP-binding site [chemical binding]; other site 941193003120 Helicase associated domain (HA2); Region: HA2; pfam04408 941193003121 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 941193003122 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941193003123 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 941193003124 putative metal binding site [ion binding]; other site 941193003125 short chain dehydrogenase; Provisional; Region: PRK06181 941193003126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193003127 NAD(P) binding site [chemical binding]; other site 941193003128 active site 941193003129 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 941193003130 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 941193003131 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 941193003132 active site 941193003133 dimer interface [polypeptide binding]; other site 941193003134 non-prolyl cis peptide bond; other site 941193003135 insertion regions; other site 941193003136 Isochorismatase family; Region: Isochorismatase; pfam00857 941193003137 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 941193003138 catalytic triad [active] 941193003139 conserved cis-peptide bond; other site 941193003140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3416 941193003141 Uncharacterized conserved protein [Function unknown]; Region: COG1432 941193003142 LabA_like proteins; Region: LabA; cd10911 941193003143 putative metal binding site [ion binding]; other site 941193003144 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 941193003145 ATP binding site [chemical binding]; other site 941193003146 Mg++ binding site [ion binding]; other site 941193003147 motif III; other site 941193003148 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941193003149 nucleotide binding region [chemical binding]; other site 941193003150 ATP-binding site [chemical binding]; other site 941193003151 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 941193003152 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941193003153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193003154 active site 941193003155 phosphorylation site [posttranslational modification] 941193003156 intermolecular recognition site; other site 941193003157 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193003158 DNA binding residues [nucleotide binding] 941193003159 dimerization interface [polypeptide binding]; other site 941193003160 Response regulator receiver domain; Region: Response_reg; pfam00072 941193003161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193003162 active site 941193003163 phosphorylation site [posttranslational modification] 941193003164 intermolecular recognition site; other site 941193003165 dimerization interface [polypeptide binding]; other site 941193003166 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941193003167 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 941193003168 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193003169 substrate binding pocket [chemical binding]; other site 941193003170 membrane-bound complex binding site; other site 941193003171 hinge residues; other site 941193003172 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193003173 substrate binding pocket [chemical binding]; other site 941193003174 membrane-bound complex binding site; other site 941193003175 hinge residues; other site 941193003176 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193003177 putative active site [active] 941193003178 heme pocket [chemical binding]; other site 941193003179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193003180 dimer interface [polypeptide binding]; other site 941193003181 phosphorylation site [posttranslational modification] 941193003182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193003183 ATP binding site [chemical binding]; other site 941193003184 Mg2+ binding site [ion binding]; other site 941193003185 G-X-G motif; other site 941193003186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193003187 active site 941193003188 phosphorylation site [posttranslational modification] 941193003189 intermolecular recognition site; other site 941193003190 dimerization interface [polypeptide binding]; other site 941193003191 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 941193003192 putative binding surface; other site 941193003193 active site 941193003194 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 941193003195 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 941193003196 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 941193003197 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 941193003198 NADPH bind site [chemical binding]; other site 941193003199 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 941193003200 putative FMN binding site [chemical binding]; other site 941193003201 NADPH bind site [chemical binding]; other site 941193003202 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 941193003203 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 941193003204 active site 941193003205 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 941193003206 catalytic triad [active] 941193003207 dimer interface [polypeptide binding]; other site 941193003208 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941193003209 active site 941193003210 motif I; other site 941193003211 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 941193003212 motif II; other site 941193003213 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 941193003214 IHF dimer interface [polypeptide binding]; other site 941193003215 IHF - DNA interface [nucleotide binding]; other site 941193003216 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193003217 active site 941193003218 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 941193003219 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193003220 substrate binding pocket [chemical binding]; other site 941193003221 membrane-bound complex binding site; other site 941193003222 hinge residues; other site 941193003223 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 941193003224 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 941193003225 Walker A/P-loop; other site 941193003226 ATP binding site [chemical binding]; other site 941193003227 Q-loop/lid; other site 941193003228 ABC transporter signature motif; other site 941193003229 Walker B; other site 941193003230 D-loop; other site 941193003231 H-loop/switch region; other site 941193003232 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 941193003233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193003234 dimer interface [polypeptide binding]; other site 941193003235 conserved gate region; other site 941193003236 putative PBP binding loops; other site 941193003237 ABC-ATPase subunit interface; other site 941193003238 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 941193003239 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 941193003240 Predicted membrane protein [Function unknown]; Region: COG1297 941193003241 BCCT family transporter; Region: BCCT; cl00569 941193003242 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 941193003243 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193003244 Walker A motif; other site 941193003245 ATP binding site [chemical binding]; other site 941193003246 Walker B motif; other site 941193003247 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 941193003248 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 941193003249 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 941193003250 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 941193003251 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 941193003252 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 941193003253 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 941193003254 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941193003255 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193003256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193003257 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941193003258 putative substrate translocation pore; other site 941193003259 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 941193003260 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 941193003261 dimer interface [polypeptide binding]; other site 941193003262 active site 941193003263 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 941193003264 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 941193003265 dimer interface [polypeptide binding]; other site 941193003266 acyl-activating enzyme (AAE) consensus motif; other site 941193003267 putative active site [active] 941193003268 AMP binding site [chemical binding]; other site 941193003269 putative CoA binding site [chemical binding]; other site 941193003270 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 941193003271 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 941193003272 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 941193003273 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193003274 DNA binding residues [nucleotide binding] 941193003275 dimerization interface [polypeptide binding]; other site 941193003276 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 941193003277 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941193003278 metal-binding site [ion binding] 941193003279 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 941193003280 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941193003281 metal-binding site [ion binding] 941193003282 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941193003283 Soluble P-type ATPase [General function prediction only]; Region: COG4087 941193003284 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 941193003285 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 941193003286 putative active site [active] 941193003287 PhoH-like protein; Region: PhoH; pfam02562 941193003288 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 941193003289 trimer interface [polypeptide binding]; other site 941193003290 dimer interface [polypeptide binding]; other site 941193003291 putative active site [active] 941193003292 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 941193003293 MoaE interaction surface [polypeptide binding]; other site 941193003294 MoeB interaction surface [polypeptide binding]; other site 941193003295 thiocarboxylated glycine; other site 941193003296 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 941193003297 MoaE homodimer interface [polypeptide binding]; other site 941193003298 MoaD interaction [polypeptide binding]; other site 941193003299 active site residues [active] 941193003300 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 941193003301 MPT binding site; other site 941193003302 trimer interface [polypeptide binding]; other site 941193003303 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 941193003304 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 941193003305 dimer interface [polypeptide binding]; other site 941193003306 putative functional site; other site 941193003307 putative MPT binding site; other site 941193003308 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 941193003309 Peptidase family U32; Region: Peptidase_U32; pfam01136 941193003310 putative protease; Provisional; Region: PRK15447 941193003311 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 941193003312 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 941193003313 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 941193003314 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 941193003315 putative active site [active] 941193003316 putative metal binding site [ion binding]; other site 941193003317 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 941193003318 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 941193003319 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 941193003320 generic binding surface I; other site 941193003321 generic binding surface II; other site 941193003322 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 941193003323 putative active site [active] 941193003324 putative catalytic site [active] 941193003325 putative Mg binding site IVb [ion binding]; other site 941193003326 putative phosphate binding site [ion binding]; other site 941193003327 putative DNA binding site [nucleotide binding]; other site 941193003328 putative Mg binding site IVa [ion binding]; other site 941193003329 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 941193003330 Uncharacterized conserved protein [Function unknown]; Region: COG4104 941193003331 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 941193003332 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 941193003333 G1 box; other site 941193003334 putative GEF interaction site [polypeptide binding]; other site 941193003335 GTP/Mg2+ binding site [chemical binding]; other site 941193003336 Switch I region; other site 941193003337 G2 box; other site 941193003338 G3 box; other site 941193003339 Switch II region; other site 941193003340 G4 box; other site 941193003341 G5 box; other site 941193003342 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 941193003343 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 941193003344 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 941193003345 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193003346 N-terminal plug; other site 941193003347 ligand-binding site [chemical binding]; other site 941193003348 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 941193003349 FecR protein; Region: FecR; pfam04773 941193003350 RNA polymerase sigma factor; Provisional; Region: PRK12528 941193003351 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941193003352 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941193003353 DNA binding residues [nucleotide binding] 941193003354 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 941193003355 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193003356 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 941193003357 EamA-like transporter family; Region: EamA; pfam00892 941193003358 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 941193003359 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 941193003360 dimerization interface [polypeptide binding]; other site 941193003361 ligand binding site [chemical binding]; other site 941193003362 NADP binding site [chemical binding]; other site 941193003363 catalytic site [active] 941193003364 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193003365 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193003366 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941193003367 putative effector binding pocket; other site 941193003368 dimerization interface [polypeptide binding]; other site 941193003369 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 941193003370 Fusaric acid resistance protein family; Region: FUSC; pfam04632 941193003371 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 941193003372 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 941193003373 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 941193003374 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193003375 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193003376 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 941193003377 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 941193003378 Walker A/P-loop; other site 941193003379 ATP binding site [chemical binding]; other site 941193003380 Q-loop/lid; other site 941193003381 ABC transporter signature motif; other site 941193003382 Walker B; other site 941193003383 D-loop; other site 941193003384 H-loop/switch region; other site 941193003385 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 941193003386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193003387 dimer interface [polypeptide binding]; other site 941193003388 conserved gate region; other site 941193003389 ABC-ATPase subunit interface; other site 941193003390 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 941193003391 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 941193003392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193003393 ABC-ATPase subunit interface; other site 941193003394 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 941193003395 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 941193003396 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 941193003397 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 941193003398 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 941193003399 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 941193003400 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 941193003401 active site 941193003402 short chain dehydrogenase; Provisional; Region: PRK05693 941193003403 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 941193003404 NADP binding site [chemical binding]; other site 941193003405 active site 941193003406 steroid binding site; other site 941193003407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193003408 Uncharacterized conserved protein [Function unknown]; Region: COG4273 941193003409 transcriptional regulator NarL; Provisional; Region: PRK10651 941193003410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193003411 active site 941193003412 phosphorylation site [posttranslational modification] 941193003413 intermolecular recognition site; other site 941193003414 dimerization interface [polypeptide binding]; other site 941193003415 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193003416 DNA binding residues [nucleotide binding] 941193003417 dimerization interface [polypeptide binding]; other site 941193003418 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 941193003419 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 941193003420 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193003421 dimerization interface [polypeptide binding]; other site 941193003422 Histidine kinase; Region: HisKA_3; pfam07730 941193003423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193003424 ATP binding site [chemical binding]; other site 941193003425 Mg2+ binding site [ion binding]; other site 941193003426 G-X-G motif; other site 941193003427 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 941193003428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193003429 putative substrate translocation pore; other site 941193003430 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 941193003431 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 941193003432 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 941193003433 [4Fe-4S] binding site [ion binding]; other site 941193003434 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 941193003435 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 941193003436 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 941193003437 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 941193003438 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 941193003439 molybdopterin cofactor binding site; other site 941193003440 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 941193003441 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 941193003442 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 941193003443 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 941193003444 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 941193003445 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 941193003446 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941193003447 FeS/SAM binding site; other site 941193003448 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 941193003449 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 941193003450 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193003451 substrate binding pocket [chemical binding]; other site 941193003452 membrane-bound complex binding site; other site 941193003453 hinge residues; other site 941193003454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 941193003455 YheO-like PAS domain; Region: PAS_6; pfam08348 941193003456 HTH domain; Region: HTH_22; pfam13309 941193003457 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 941193003458 hydroxyglutarate oxidase; Provisional; Region: PRK11728 941193003459 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 941193003460 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 941193003461 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 941193003462 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 941193003463 ATP binding site [chemical binding]; other site 941193003464 Mg++ binding site [ion binding]; other site 941193003465 motif III; other site 941193003466 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941193003467 nucleotide binding region [chemical binding]; other site 941193003468 ATP-binding site [chemical binding]; other site 941193003469 AMP-binding domain protein; Validated; Region: PRK07529 941193003470 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 941193003471 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 941193003472 acyl-activating enzyme (AAE) consensus motif; other site 941193003473 putative AMP binding site [chemical binding]; other site 941193003474 putative active site [active] 941193003475 putative CoA binding site [chemical binding]; other site 941193003476 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 941193003477 putative hydrolase; Provisional; Region: PRK11460 941193003478 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 941193003479 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193003480 substrate binding pocket [chemical binding]; other site 941193003481 membrane-bound complex binding site; other site 941193003482 hinge residues; other site 941193003483 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 941193003484 SnoaL-like domain; Region: SnoaL_2; pfam12680 941193003485 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 941193003486 putative C-terminal domain interface [polypeptide binding]; other site 941193003487 putative GSH binding site [chemical binding]; other site 941193003488 putative dimer interface [polypeptide binding]; other site 941193003489 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 941193003490 putative N-terminal domain interface [polypeptide binding]; other site 941193003491 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 941193003492 putative active site [active] 941193003493 GIY-YIG motif/motif A; other site 941193003494 putative metal binding site [ion binding]; other site 941193003495 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 941193003496 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 941193003497 trimer interface [polypeptide binding]; other site 941193003498 active site 941193003499 substrate binding site [chemical binding]; other site 941193003500 CoA binding site [chemical binding]; other site 941193003501 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 941193003502 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 941193003503 C-terminal domain interface [polypeptide binding]; other site 941193003504 GSH binding site (G-site) [chemical binding]; other site 941193003505 dimer interface [polypeptide binding]; other site 941193003506 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 941193003507 substrate binding pocket (H-site) [chemical binding]; other site 941193003508 N-terminal domain interface [polypeptide binding]; other site 941193003509 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 941193003510 Nucleoid-associated protein [General function prediction only]; Region: COG3081 941193003511 nucleoid-associated protein NdpA; Validated; Region: PRK00378 941193003512 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 941193003513 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 941193003514 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 941193003515 hydrophobic ligand binding site; other site 941193003516 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 941193003517 Isochorismatase family; Region: Isochorismatase; pfam00857 941193003518 catalytic triad [active] 941193003519 dimer interface [polypeptide binding]; other site 941193003520 conserved cis-peptide bond; other site 941193003521 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 941193003522 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193003523 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 941193003524 dimerization interface [polypeptide binding]; other site 941193003525 substrate binding pocket [chemical binding]; other site 941193003526 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 941193003527 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 941193003528 C-terminal domain interface [polypeptide binding]; other site 941193003529 GSH binding site (G-site) [chemical binding]; other site 941193003530 dimer interface [polypeptide binding]; other site 941193003531 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 941193003532 dimer interface [polypeptide binding]; other site 941193003533 N-terminal domain interface [polypeptide binding]; other site 941193003534 putative substrate binding pocket (H-site) [chemical binding]; other site 941193003535 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 941193003536 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 941193003537 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219 941193003538 switch II binding region; other site 941193003539 Rac1 P-loop interaction site [polypeptide binding]; other site 941193003540 GTP binding residues [chemical binding]; other site 941193003541 switch I binding region; other site 941193003542 ADP-ribosyltransferase exoenzyme; Region: ADPrib_exo_Tox; pfam03496 941193003543 active site 941193003544 conformational flexibility of ligand binding pocket; other site 941193003545 ADP-ribosylating toxin turn-turn motif; other site 941193003546 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 941193003547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193003548 S-adenosylmethionine binding site [chemical binding]; other site 941193003549 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 941193003550 transmembrane helices; other site 941193003551 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 941193003552 TrkA-C domain; Region: TrkA_C; pfam02080 941193003553 TrkA-C domain; Region: TrkA_C; pfam02080 941193003554 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 941193003555 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 941193003556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193003557 Walker A/P-loop; other site 941193003558 ATP binding site [chemical binding]; other site 941193003559 Q-loop/lid; other site 941193003560 ABC transporter signature motif; other site 941193003561 Walker B; other site 941193003562 D-loop; other site 941193003563 H-loop/switch region; other site 941193003564 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941193003565 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 941193003566 TM-ABC transporter signature motif; other site 941193003567 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 941193003568 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 941193003569 zinc binding site [ion binding]; other site 941193003570 putative ligand binding site [chemical binding]; other site 941193003571 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 941193003572 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 941193003573 HIGH motif; other site 941193003574 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 941193003575 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 941193003576 active site 941193003577 KMSKS motif; other site 941193003578 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 941193003579 tRNA binding surface [nucleotide binding]; other site 941193003580 anticodon binding site; other site 941193003581 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 941193003582 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 941193003583 multifunctional aminopeptidase A; Provisional; Region: PRK00913 941193003584 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 941193003585 interface (dimer of trimers) [polypeptide binding]; other site 941193003586 Substrate-binding/catalytic site; other site 941193003587 Zn-binding sites [ion binding]; other site 941193003588 Cupin domain; Region: Cupin_2; pfam07883 941193003589 Helix-turn-helix domain; Region: HTH_18; pfam12833 941193003590 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 941193003591 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 941193003592 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 941193003593 Predicted permeases [General function prediction only]; Region: COG0795 941193003594 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 941193003595 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 941193003596 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 941193003597 Predicted membrane protein/domain [Function unknown]; Region: COG1714 941193003598 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 941193003599 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 941193003600 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941193003601 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 941193003602 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 941193003603 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 941193003604 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 941193003605 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 941193003606 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 941193003607 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 941193003608 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 941193003609 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 941193003610 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 941193003611 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 941193003612 Protein export membrane protein; Region: SecD_SecF; cl14618 941193003613 hypothetical protein; Provisional; Region: PRK11280 941193003614 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 941193003615 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 941193003616 active site 941193003617 dimerization interface [polypeptide binding]; other site 941193003618 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 941193003619 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 941193003620 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 941193003621 serine O-acetyltransferase; Region: cysE; TIGR01172 941193003622 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 941193003623 trimer interface [polypeptide binding]; other site 941193003624 active site 941193003625 substrate binding site [chemical binding]; other site 941193003626 CoA binding site [chemical binding]; other site 941193003627 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 941193003628 Rrf2 family protein; Region: rrf2_super; TIGR00738 941193003629 cysteine desulfurase; Provisional; Region: PRK14012 941193003630 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 941193003631 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941193003632 catalytic residue [active] 941193003633 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 941193003634 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 941193003635 trimerization site [polypeptide binding]; other site 941193003636 active site 941193003637 iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011 941193003638 co-chaperone HscB; Provisional; Region: hscB; PRK00294 941193003639 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 941193003640 HSP70 interaction site [polypeptide binding]; other site 941193003641 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 941193003642 chaperone protein HscA; Provisional; Region: hscA; PRK05183 941193003643 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 941193003644 nucleotide binding site [chemical binding]; other site 941193003645 putative NEF/HSP70 interaction site [polypeptide binding]; other site 941193003646 SBD interface [polypeptide binding]; other site 941193003647 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 941193003648 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941193003649 catalytic loop [active] 941193003650 iron binding site [ion binding]; other site 941193003651 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 941193003652 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 941193003653 active site 941193003654 multimer interface [polypeptide binding]; other site 941193003655 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 941193003656 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941193003657 FeS/SAM binding site; other site 941193003658 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 941193003659 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941193003660 binding surface 941193003661 TPR motif; other site 941193003662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941193003663 binding surface 941193003664 TPR motif; other site 941193003665 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 941193003666 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941193003667 non-specific DNA binding site [nucleotide binding]; other site 941193003668 salt bridge; other site 941193003669 sequence-specific DNA binding site [nucleotide binding]; other site 941193003670 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 941193003671 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 941193003672 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 941193003673 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 941193003674 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 941193003675 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 941193003676 dimer interface [polypeptide binding]; other site 941193003677 motif 1; other site 941193003678 active site 941193003679 motif 2; other site 941193003680 motif 3; other site 941193003681 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 941193003682 anticodon binding site; other site 941193003683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 941193003684 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 941193003685 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 941193003686 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 941193003687 Trp docking motif [polypeptide binding]; other site 941193003688 active site 941193003689 GTP-binding protein Der; Reviewed; Region: PRK00093 941193003690 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 941193003691 G1 box; other site 941193003692 GTP/Mg2+ binding site [chemical binding]; other site 941193003693 Switch I region; other site 941193003694 G2 box; other site 941193003695 Switch II region; other site 941193003696 G3 box; other site 941193003697 G4 box; other site 941193003698 G5 box; other site 941193003699 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 941193003700 G1 box; other site 941193003701 GTP/Mg2+ binding site [chemical binding]; other site 941193003702 Switch I region; other site 941193003703 G2 box; other site 941193003704 G3 box; other site 941193003705 Switch II region; other site 941193003706 G4 box; other site 941193003707 G5 box; other site 941193003708 methionine aminotransferase; Validated; Region: PRK09082 941193003709 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941193003710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193003711 homodimer interface [polypeptide binding]; other site 941193003712 catalytic residue [active] 941193003713 C-N hydrolase family amidase; Provisional; Region: PRK10438 941193003714 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 941193003715 putative active site [active] 941193003716 catalytic triad [active] 941193003717 dimer interface [polypeptide binding]; other site 941193003718 multimer interface [polypeptide binding]; other site 941193003719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753 941193003720 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 941193003721 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 941193003722 active site 941193003723 catalytic tetrad [active] 941193003724 2-isopropylmalate synthase; Validated; Region: PRK03739 941193003725 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 941193003726 active site 941193003727 catalytic residues [active] 941193003728 metal binding site [ion binding]; metal-binding site 941193003729 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 941193003730 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 941193003731 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193003732 N-terminal plug; other site 941193003733 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 941193003734 ligand-binding site [chemical binding]; other site 941193003735 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 941193003736 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 941193003737 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 941193003738 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 941193003739 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 941193003740 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 941193003741 Peptidase family M23; Region: Peptidase_M23; pfam01551 941193003742 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 941193003743 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 941193003744 AZL_007950 family protein; Region: AZL_007950_fam; TIGR04061 941193003745 Isochorismatase family; Region: Isochorismatase; pfam00857 941193003746 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 941193003747 catalytic triad [active] 941193003748 conserved cis-peptide bond; other site 941193003749 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 941193003750 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 941193003751 conserved cys residue [active] 941193003752 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193003753 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 941193003754 DctM-like transporters; Region: DctM; pfam06808 941193003755 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 941193003756 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 941193003757 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 941193003758 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 941193003759 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193003760 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193003761 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193003762 dimerization interface [polypeptide binding]; other site 941193003763 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 941193003764 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 941193003765 generic binding surface II; other site 941193003766 generic binding surface I; other site 941193003767 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 941193003768 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193003769 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 941193003770 dimerization interface [polypeptide binding]; other site 941193003771 substrate binding pocket [chemical binding]; other site 941193003772 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 941193003773 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 941193003774 active site 941193003775 Zn binding site [ion binding]; other site 941193003776 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 941193003777 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941193003778 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193003779 DNA binding residues [nucleotide binding] 941193003780 dimerization interface [polypeptide binding]; other site 941193003781 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 941193003782 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 941193003783 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 941193003784 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 941193003785 active site 941193003786 GMP synthase; Reviewed; Region: guaA; PRK00074 941193003787 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 941193003788 AMP/PPi binding site [chemical binding]; other site 941193003789 candidate oxyanion hole; other site 941193003790 catalytic triad [active] 941193003791 potential glutamine specificity residues [chemical binding]; other site 941193003792 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 941193003793 ATP Binding subdomain [chemical binding]; other site 941193003794 Dimerization subdomain; other site 941193003795 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 941193003796 active site 941193003797 cosubstrate binding site; other site 941193003798 substrate binding site [chemical binding]; other site 941193003799 catalytic site [active] 941193003800 Chordopoxvirus A20R protein; Region: Chordopox_A20R; pfam05941 941193003801 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 941193003802 oxidoreductase; Provisional; Region: PRK06196 941193003803 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193003804 NAD(P) binding site [chemical binding]; other site 941193003805 active site 941193003806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193003807 putative substrate translocation pore; other site 941193003808 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941193003809 Cupin; Region: Cupin_6; pfam12852 941193003810 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941193003811 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193003812 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 941193003813 Prostaglandin dehydrogenases; Region: PGDH; cd05288 941193003814 NAD(P) binding site [chemical binding]; other site 941193003815 substrate binding site [chemical binding]; other site 941193003816 dimer interface [polypeptide binding]; other site 941193003817 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 941193003818 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 941193003819 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 941193003820 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 941193003821 nucleoside/Zn binding site; other site 941193003822 dimer interface [polypeptide binding]; other site 941193003823 catalytic motif [active] 941193003824 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 941193003825 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 941193003826 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 941193003827 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 941193003828 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193003829 substrate binding pocket [chemical binding]; other site 941193003830 membrane-bound complex binding site; other site 941193003831 hinge residues; other site 941193003832 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 941193003833 N-acetyl-D-glucosamine binding site [chemical binding]; other site 941193003834 catalytic residue [active] 941193003835 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 941193003836 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 941193003837 dimerization interface [polypeptide binding]; other site 941193003838 ATP binding site [chemical binding]; other site 941193003839 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 941193003840 dimerization interface [polypeptide binding]; other site 941193003841 ATP binding site [chemical binding]; other site 941193003842 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 941193003843 putative active site [active] 941193003844 catalytic triad [active] 941193003845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 941193003846 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 941193003847 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 941193003848 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 941193003849 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 941193003850 active site turn [active] 941193003851 phosphorylation site [posttranslational modification] 941193003852 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 941193003853 HPr interaction site; other site 941193003854 glycerol kinase (GK) interaction site [polypeptide binding]; other site 941193003855 active site 941193003856 phosphorylation site [posttranslational modification] 941193003857 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 941193003858 regulatory protein interface [polypeptide binding]; other site 941193003859 active site 941193003860 regulatory phosphorylation site [posttranslational modification]; other site 941193003861 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 941193003862 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 941193003863 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 941193003864 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 941193003865 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 941193003866 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 941193003867 dimer interface [polypeptide binding]; other site 941193003868 active site 941193003869 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 941193003870 dimer interface [polypeptide binding]; other site 941193003871 active site 941193003872 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 941193003873 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 941193003874 active site 941193003875 dimer interface [polypeptide binding]; other site 941193003876 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 941193003877 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193003878 DNA-binding site [nucleotide binding]; DNA binding site 941193003879 UTRA domain; Region: UTRA; pfam07702 941193003880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 941193003881 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 941193003882 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 941193003883 nudix motif; other site 941193003884 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 941193003885 putative active site [active] 941193003886 putative CoA binding site [chemical binding]; other site 941193003887 nudix motif; other site 941193003888 metal binding site [ion binding]; metal-binding site 941193003889 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 941193003890 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 941193003891 trimer interface [polypeptide binding]; other site 941193003892 putative metal binding site [ion binding]; other site 941193003893 Predicted Fe-S protein [General function prediction only]; Region: COG3313 941193003894 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 941193003895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193003896 ATP-grasp domain; Region: ATP-grasp; pfam02222 941193003897 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 941193003898 active site 941193003899 catalytic triad [active] 941193003900 oxyanion hole [active] 941193003901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193003902 metabolite-proton symporter; Region: 2A0106; TIGR00883 941193003903 putative substrate translocation pore; other site 941193003904 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 941193003905 Domain of unknown function DUF21; Region: DUF21; pfam01595 941193003906 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 941193003907 Transporter associated domain; Region: CorC_HlyC; smart01091 941193003908 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 941193003909 signal recognition particle protein; Provisional; Region: PRK10867 941193003910 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 941193003911 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 941193003912 P loop; other site 941193003913 GTP binding site [chemical binding]; other site 941193003914 Signal peptide binding domain; Region: SRP_SPB; pfam02978 941193003915 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 941193003916 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 941193003917 RimM N-terminal domain; Region: RimM; pfam01782 941193003918 PRC-barrel domain; Region: PRC; pfam05239 941193003919 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 941193003920 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 941193003921 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 941193003922 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 941193003923 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 941193003924 TrkA-N domain; Region: TrkA_N; pfam02254 941193003925 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 941193003926 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 941193003927 active site 941193003928 Int/Topo IB signature motif; other site 941193003929 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 941193003930 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 941193003931 dimerization domain [polypeptide binding]; other site 941193003932 dimer interface [polypeptide binding]; other site 941193003933 catalytic residues [active] 941193003934 homoserine dehydrogenase; Provisional; Region: PRK06349 941193003935 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 941193003936 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 941193003937 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 941193003938 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 941193003939 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 941193003940 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193003941 catalytic residue [active] 941193003942 Chlorophyllase enzyme; Region: Chlorophyllase2; pfam12740 941193003943 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 941193003944 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 941193003945 CoA-transferase family III; Region: CoA_transf_3; pfam02515 941193003946 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 941193003947 nucleotide binding site [chemical binding]; other site 941193003948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789 941193003949 PspA/IM30 family; Region: PspA_IM30; pfam04012 941193003950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 941193003951 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 941193003952 ATPase involved in DNA repair; Region: DUF3686; pfam12458 941193003953 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 941193003954 linker region; other site 941193003955 AAA domain; Region: AAA_22; pfam13401 941193003956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193003957 Walker A motif; other site 941193003958 ATP binding site [chemical binding]; other site 941193003959 Walker B motif; other site 941193003960 Catalytic domain of vertebrate phospholipase D6 and similar proteins; Region: PLDc_vPLD6_like; cd09171 941193003961 PLD-like domain; Region: PLDc_2; pfam13091 941193003962 putative active site [active] 941193003963 catalytic site [active] 941193003964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 941193003965 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 941193003966 DHH family; Region: DHH; pfam01368 941193003967 DHHA1 domain; Region: DHHA1; pfam02272 941193003968 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 941193003969 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 941193003970 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 941193003971 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 941193003972 active site 941193003973 Zn binding site [ion binding]; other site 941193003974 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 941193003975 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 941193003976 active site 941193003977 FMN binding site [chemical binding]; other site 941193003978 substrate binding site [chemical binding]; other site 941193003979 homotetramer interface [polypeptide binding]; other site 941193003980 catalytic residue [active] 941193003981 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193003982 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193003983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193003984 putative substrate translocation pore; other site 941193003985 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941193003986 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 941193003987 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 941193003988 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941193003989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193003990 active site 941193003991 phosphorylation site [posttranslational modification] 941193003992 intermolecular recognition site; other site 941193003993 dimerization interface [polypeptide binding]; other site 941193003994 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193003995 DNA binding residues [nucleotide binding] 941193003996 dimerization interface [polypeptide binding]; other site 941193003997 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941193003998 Protein of unknown function (DUF533); Region: DUF533; pfam04391 941193003999 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 941193004000 putative metal binding site [ion binding]; other site 941193004001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193004002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193004003 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193004004 dimerization interface [polypeptide binding]; other site 941193004005 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 941193004006 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 941193004007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193004008 putative substrate translocation pore; other site 941193004009 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 941193004010 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 941193004011 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193004012 dimerization interface [polypeptide binding]; other site 941193004013 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193004014 dimer interface [polypeptide binding]; other site 941193004015 putative CheW interface [polypeptide binding]; other site 941193004016 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 941193004017 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 941193004018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193004019 S-adenosylmethionine binding site [chemical binding]; other site 941193004020 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 941193004021 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 941193004022 putative binding surface; other site 941193004023 active site 941193004024 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 941193004025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193004026 ATP binding site [chemical binding]; other site 941193004027 Mg2+ binding site [ion binding]; other site 941193004028 G-X-G motif; other site 941193004029 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 941193004030 Response regulator receiver domain; Region: Response_reg; pfam00072 941193004031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193004032 active site 941193004033 phosphorylation site [posttranslational modification] 941193004034 intermolecular recognition site; other site 941193004035 dimerization interface [polypeptide binding]; other site 941193004036 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 941193004037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193004038 active site 941193004039 phosphorylation site [posttranslational modification] 941193004040 intermolecular recognition site; other site 941193004041 CheB methylesterase; Region: CheB_methylest; pfam01339 941193004042 Response regulator receiver domain; Region: Response_reg; pfam00072 941193004043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193004044 active site 941193004045 phosphorylation site [posttranslational modification] 941193004046 intermolecular recognition site; other site 941193004047 dimerization interface [polypeptide binding]; other site 941193004048 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193004049 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193004050 metal binding site [ion binding]; metal-binding site 941193004051 active site 941193004052 I-site; other site 941193004053 peptide chain release factor 2; Provisional; Region: PRK08787 941193004054 This domain is found in peptide chain release factors; Region: PCRF; smart00937 941193004055 RF-1 domain; Region: RF-1; pfam00472 941193004056 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 941193004057 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 941193004058 dimer interface [polypeptide binding]; other site 941193004059 putative anticodon binding site; other site 941193004060 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 941193004061 motif 1; other site 941193004062 active site 941193004063 motif 2; other site 941193004064 motif 3; other site 941193004065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 941193004066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3930 941193004067 Uncharacterized conserved protein [Function unknown]; Region: COG2013 941193004068 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 941193004069 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 941193004070 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 941193004071 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 941193004072 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 941193004073 putative ADP-ribose binding site [chemical binding]; other site 941193004074 putative active site [active] 941193004075 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 941193004076 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 941193004077 ligand binding site [chemical binding]; other site 941193004078 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 941193004079 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 941193004080 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 941193004081 metal-binding site [ion binding] 941193004082 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941193004083 Soluble P-type ATPase [General function prediction only]; Region: COG4087 941193004084 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 941193004085 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 941193004086 DNA binding residues [nucleotide binding] 941193004087 dimer interface [polypeptide binding]; other site 941193004088 putative metal binding site [ion binding]; other site 941193004089 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 941193004090 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 941193004091 adenylate kinase; Reviewed; Region: adk; PRK00279 941193004092 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 941193004093 AMP-binding site [chemical binding]; other site 941193004094 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 941193004095 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 941193004096 Glycoprotease family; Region: Peptidase_M22; pfam00814 941193004097 Protein of unknown function DUF72; Region: DUF72; cl00777 941193004098 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 941193004099 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 941193004100 tetramer interface [polypeptide binding]; other site 941193004101 active site 941193004102 Mg2+/Mn2+ binding site [ion binding]; other site 941193004103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 941193004104 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 941193004105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193004106 S-adenosylmethionine binding site [chemical binding]; other site 941193004107 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 941193004108 Cytochrome P450; Region: p450; cl12078 941193004109 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193004110 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193004111 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 941193004112 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 941193004113 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193004114 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193004115 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 941193004116 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 941193004117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 941193004118 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 941193004119 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 941193004120 putative acyl-acceptor binding pocket; other site 941193004121 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941193004122 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 941193004123 Walker A/P-loop; other site 941193004124 ATP binding site [chemical binding]; other site 941193004125 Q-loop/lid; other site 941193004126 ABC transporter signature motif; other site 941193004127 Walker B; other site 941193004128 D-loop; other site 941193004129 H-loop/switch region; other site 941193004130 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 941193004131 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 941193004132 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 941193004133 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 941193004134 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 941193004135 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 941193004136 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 941193004137 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941193004138 catalytic residue [active] 941193004139 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 941193004140 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 941193004141 putative trimer interface [polypeptide binding]; other site 941193004142 putative CoA binding site [chemical binding]; other site 941193004143 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 941193004144 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 941193004145 ArsC family; Region: ArsC; pfam03960 941193004146 putative catalytic residues [active] 941193004147 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 941193004148 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 941193004149 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 941193004150 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 941193004151 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941193004152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193004153 homodimer interface [polypeptide binding]; other site 941193004154 catalytic residue [active] 941193004155 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 941193004156 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 941193004157 metal binding triad; other site 941193004158 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 941193004159 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941193004160 Zn2+ binding site [ion binding]; other site 941193004161 Mg2+ binding site [ion binding]; other site 941193004162 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 941193004163 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 941193004164 methionine aminopeptidase; Provisional; Region: PRK08671 941193004165 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 941193004166 active site 941193004167 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 941193004168 rRNA interaction site [nucleotide binding]; other site 941193004169 S8 interaction site; other site 941193004170 putative laminin-1 binding site; other site 941193004171 elongation factor Ts; Provisional; Region: tsf; PRK09377 941193004172 UBA/TS-N domain; Region: UBA; pfam00627 941193004173 Elongation factor TS; Region: EF_TS; pfam00889 941193004174 Elongation factor TS; Region: EF_TS; pfam00889 941193004175 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 941193004176 putative nucleotide binding site [chemical binding]; other site 941193004177 uridine monophosphate binding site [chemical binding]; other site 941193004178 homohexameric interface [polypeptide binding]; other site 941193004179 ribosome recycling factor; Reviewed; Region: frr; PRK00083 941193004180 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 941193004181 hinge region; other site 941193004182 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 941193004183 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 941193004184 catalytic residue [active] 941193004185 putative FPP diphosphate binding site; other site 941193004186 putative FPP binding hydrophobic cleft; other site 941193004187 dimer interface [polypeptide binding]; other site 941193004188 putative IPP diphosphate binding site; other site 941193004189 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 941193004190 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 941193004191 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 941193004192 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 941193004193 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 941193004194 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 941193004195 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 941193004196 zinc metallopeptidase RseP; Provisional; Region: PRK10779 941193004197 active site 941193004198 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 941193004199 protein binding site [polypeptide binding]; other site 941193004200 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 941193004201 protein binding site [polypeptide binding]; other site 941193004202 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 941193004203 putative substrate binding region [chemical binding]; other site 941193004204 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 941193004205 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 941193004206 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 941193004207 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 941193004208 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 941193004209 Surface antigen; Region: Bac_surface_Ag; pfam01103 941193004210 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 941193004211 periplasmic chaperone; Provisional; Region: PRK10780 941193004212 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 941193004213 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 941193004214 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 941193004215 trimer interface [polypeptide binding]; other site 941193004216 active site 941193004217 UDP-GlcNAc binding site [chemical binding]; other site 941193004218 lipid binding site [chemical binding]; lipid-binding site 941193004219 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 941193004220 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 941193004221 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 941193004222 active site 941193004223 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 941193004224 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 941193004225 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 941193004226 RNA/DNA hybrid binding site [nucleotide binding]; other site 941193004227 active site 941193004228 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 941193004229 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 941193004230 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 941193004231 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 941193004232 putative active site [active] 941193004233 putative PHP Thumb interface [polypeptide binding]; other site 941193004234 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 941193004235 generic binding surface II; other site 941193004236 generic binding surface I; other site 941193004237 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 941193004238 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 941193004239 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 941193004240 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 941193004241 Ligand Binding Site [chemical binding]; other site 941193004242 TilS substrate binding domain; Region: TilS; pfam09179 941193004243 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 941193004244 CTP synthetase; Validated; Region: pyrG; PRK05380 941193004245 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 941193004246 Catalytic site [active] 941193004247 active site 941193004248 UTP binding site [chemical binding]; other site 941193004249 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 941193004250 active site 941193004251 putative oxyanion hole; other site 941193004252 catalytic triad [active] 941193004253 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 941193004254 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 941193004255 enolase; Provisional; Region: eno; PRK00077 941193004256 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 941193004257 dimer interface [polypeptide binding]; other site 941193004258 metal binding site [ion binding]; metal-binding site 941193004259 substrate binding pocket [chemical binding]; other site 941193004260 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 941193004261 Septum formation initiator; Region: DivIC; cl17659 941193004262 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 941193004263 substrate binding site; other site 941193004264 dimer interface; other site 941193004265 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 941193004266 CPxP motif; other site 941193004267 putative inner membrane protein; Provisional; Region: PRK11099 941193004268 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193004269 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193004270 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470 941193004271 putative effector binding pocket; other site 941193004272 putative dimerization interface [polypeptide binding]; other site 941193004273 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 941193004274 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 941193004275 substrate binding site [chemical binding]; other site 941193004276 catalytic Zn binding site [ion binding]; other site 941193004277 NAD binding site [chemical binding]; other site 941193004278 structural Zn binding site [ion binding]; other site 941193004279 dimer interface [polypeptide binding]; other site 941193004280 S-formylglutathione hydrolase; Region: PLN02442 941193004281 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 941193004282 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 941193004283 homotrimer interaction site [polypeptide binding]; other site 941193004284 zinc binding site [ion binding]; other site 941193004285 CDP-binding sites; other site 941193004286 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 941193004287 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 941193004288 Permutation of conserved domain; other site 941193004289 active site 941193004290 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 941193004291 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 941193004292 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 941193004293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193004294 S-adenosylmethionine binding site [chemical binding]; other site 941193004295 Peptidase family M23; Region: Peptidase_M23; pfam01551 941193004296 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 941193004297 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 941193004298 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941193004299 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 941193004300 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941193004301 DNA binding residues [nucleotide binding] 941193004302 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 941193004303 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 941193004304 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 941193004305 MutS domain I; Region: MutS_I; pfam01624 941193004306 MutS domain II; Region: MutS_II; pfam05188 941193004307 MutS domain III; Region: MutS_III; pfam05192 941193004308 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 941193004309 Walker A/P-loop; other site 941193004310 ATP binding site [chemical binding]; other site 941193004311 Q-loop/lid; other site 941193004312 ABC transporter signature motif; other site 941193004313 Walker B; other site 941193004314 D-loop; other site 941193004315 H-loop/switch region; other site 941193004316 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 941193004317 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 941193004318 dimer interface [polypeptide binding]; other site 941193004319 active site 941193004320 Int/Topo IB signature motif; other site 941193004321 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 941193004322 Protein of unknown function (DUF550); Region: DUF550; pfam04447 941193004323 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 941193004324 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193004325 DNA binding residues [nucleotide binding] 941193004326 dimerization interface [polypeptide binding]; other site 941193004327 ParB-like nuclease domain; Region: ParBc; pfam02195 941193004328 KorB domain; Region: KorB; pfam08535 941193004329 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 941193004330 Predicted transcriptional regulator [Transcription]; Region: COG2932 941193004331 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 941193004332 Catalytic site [active] 941193004333 Helix-turn-helix domain; Region: HTH_36; pfam13730 941193004334 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 941193004335 YcfA-like protein; Region: YcfA; pfam07927 941193004336 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 941193004337 Predicted chitinase [General function prediction only]; Region: COG3179 941193004338 catalytic residue [active] 941193004339 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 941193004340 active site 941193004341 Phage terminase, small subunit; Region: Terminase_4; pfam05119 941193004342 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 941193004343 Phage-related protein [Function unknown]; Region: COG4695 941193004344 Phage portal protein; Region: Phage_portal; pfam04860 941193004345 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 941193004346 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 941193004347 Phage capsid family; Region: Phage_capsid; pfam05065 941193004348 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 941193004349 oligomerization interface [polypeptide binding]; other site 941193004350 Phage-related minor tail protein [Function unknown]; Region: COG5281 941193004351 tape measure domain; Region: tape_meas_nterm; TIGR02675 941193004352 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 941193004353 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 941193004354 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 941193004355 recombinase A; Provisional; Region: recA; PRK09354 941193004356 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 941193004357 hexamer interface [polypeptide binding]; other site 941193004358 Walker A motif; other site 941193004359 ATP binding site [chemical binding]; other site 941193004360 Walker B motif; other site 941193004361 recombination regulator RecX; Reviewed; Region: recX; PRK00117 941193004362 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 941193004363 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 941193004364 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941193004365 Beta-Casp domain; Region: Beta-Casp; smart01027 941193004366 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 941193004367 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 941193004368 XFP N-terminal domain; Region: XFP_N; pfam09364 941193004369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 941193004370 Domain of unknown function (DUF4146); Region: DUF4146; pfam13652 941193004371 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 941193004372 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941193004373 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 941193004374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193004375 dimer interface [polypeptide binding]; other site 941193004376 conserved gate region; other site 941193004377 putative PBP binding loops; other site 941193004378 ABC-ATPase subunit interface; other site 941193004379 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 941193004380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193004381 dimer interface [polypeptide binding]; other site 941193004382 conserved gate region; other site 941193004383 putative PBP binding loops; other site 941193004384 ABC-ATPase subunit interface; other site 941193004385 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 941193004386 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193004387 Walker A/P-loop; other site 941193004388 ATP binding site [chemical binding]; other site 941193004389 Q-loop/lid; other site 941193004390 ABC transporter signature motif; other site 941193004391 Walker B; other site 941193004392 D-loop; other site 941193004393 H-loop/switch region; other site 941193004394 TOBE domain; Region: TOBE_2; pfam08402 941193004395 Uncharacterized conserved protein [Function unknown]; Region: COG3148 941193004396 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 941193004397 EamA-like transporter family; Region: EamA; pfam00892 941193004398 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941193004399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193004400 active site 941193004401 phosphorylation site [posttranslational modification] 941193004402 intermolecular recognition site; other site 941193004403 dimerization interface [polypeptide binding]; other site 941193004404 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193004405 DNA binding residues [nucleotide binding] 941193004406 dimerization interface [polypeptide binding]; other site 941193004407 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 941193004408 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 941193004409 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 941193004410 active site 941193004411 FMN binding site [chemical binding]; other site 941193004412 substrate binding site [chemical binding]; other site 941193004413 3Fe-4S cluster binding site [ion binding]; other site 941193004414 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 941193004415 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 941193004416 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941193004417 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193004418 DNA binding residues [nucleotide binding] 941193004419 dimerization interface [polypeptide binding]; other site 941193004420 Predicted amidohydrolase [General function prediction only]; Region: COG0388 941193004421 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 941193004422 putative active site [active] 941193004423 catalytic triad [active] 941193004424 putative dimer interface [polypeptide binding]; other site 941193004425 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 941193004426 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 941193004427 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 941193004428 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 941193004429 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 941193004430 DNA binding site [nucleotide binding] 941193004431 active site 941193004432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193004433 metabolite-proton symporter; Region: 2A0106; TIGR00883 941193004434 putative substrate translocation pore; other site 941193004435 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193004436 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193004437 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 941193004438 putative dimerization interface [polypeptide binding]; other site 941193004439 putative substrate binding pocket [chemical binding]; other site 941193004440 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193004441 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 941193004442 active site 941193004443 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 941193004444 CoA-transferase family III; Region: CoA_transf_3; pfam02515 941193004445 enoyl-CoA hydratase; Provisional; Region: PRK08138 941193004446 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941193004447 substrate binding site [chemical binding]; other site 941193004448 oxyanion hole (OAH) forming residues; other site 941193004449 trimer interface [polypeptide binding]; other site 941193004450 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 941193004451 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 941193004452 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 941193004453 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 941193004454 acetyl-CoA acetyltransferase; Provisional; Region: PRK08131 941193004455 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 941193004456 dimer interface [polypeptide binding]; other site 941193004457 active site 941193004458 outer membrane porin, OprD family; Region: OprD; pfam03573 941193004459 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 941193004460 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193004461 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 941193004462 putative dimerization interface [polypeptide binding]; other site 941193004463 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 941193004464 GlpM protein; Region: GlpM; pfam06942 941193004465 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 941193004466 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 941193004467 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 941193004468 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 941193004469 glycerol kinase; Provisional; Region: glpK; PRK00047 941193004470 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 941193004471 N- and C-terminal domain interface [polypeptide binding]; other site 941193004472 active site 941193004473 MgATP binding site [chemical binding]; other site 941193004474 catalytic site [active] 941193004475 metal binding site [ion binding]; metal-binding site 941193004476 glycerol binding site [chemical binding]; other site 941193004477 homotetramer interface [polypeptide binding]; other site 941193004478 homodimer interface [polypeptide binding]; other site 941193004479 FBP binding site [chemical binding]; other site 941193004480 protein IIAGlc interface [polypeptide binding]; other site 941193004481 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 941193004482 amphipathic channel; other site 941193004483 Asn-Pro-Ala signature motifs; other site 941193004484 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 941193004485 putative deacylase active site [active] 941193004486 glycerol kinase; Region: glycerol_kin; TIGR01311 941193004487 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 941193004488 N- and C-terminal domain interface [polypeptide binding]; other site 941193004489 active site 941193004490 MgATP binding site [chemical binding]; other site 941193004491 catalytic site [active] 941193004492 metal binding site [ion binding]; metal-binding site 941193004493 glycerol binding site [chemical binding]; other site 941193004494 homotetramer interface [polypeptide binding]; other site 941193004495 homodimer interface [polypeptide binding]; other site 941193004496 FBP binding site [chemical binding]; other site 941193004497 protein IIAGlc interface [polypeptide binding]; other site 941193004498 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 941193004499 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 941193004500 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941193004501 metal-binding site [ion binding] 941193004502 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 941193004503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193004504 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 941193004505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193004506 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 941193004507 putative substrate translocation pore; other site 941193004508 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 941193004509 Helix-turn-helix domain; Region: HTH_18; pfam12833 941193004510 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193004511 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 941193004512 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 941193004513 tetrameric interface [polypeptide binding]; other site 941193004514 NAD binding site [chemical binding]; other site 941193004515 catalytic residues [active] 941193004516 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 941193004517 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 941193004518 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 941193004519 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 941193004520 acyl-activating enzyme (AAE) consensus motif; other site 941193004521 putative AMP binding site [chemical binding]; other site 941193004522 putative active site [active] 941193004523 putative CoA binding site [chemical binding]; other site 941193004524 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 941193004525 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 941193004526 putative NAD(P) binding site [chemical binding]; other site 941193004527 dimer interface [polypeptide binding]; other site 941193004528 Uncharacterized conserved protein [Function unknown]; Region: COG1359 941193004529 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193004530 transcriptional activator TtdR; Provisional; Region: PRK09801 941193004531 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941193004532 putative effector binding pocket; other site 941193004533 dimerization interface [polypeptide binding]; other site 941193004534 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 941193004535 RNAase interaction site [polypeptide binding]; other site 941193004536 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 941193004537 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 941193004538 active site 941193004539 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 941193004540 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 941193004541 DNA binding site [nucleotide binding] 941193004542 domain linker motif; other site 941193004543 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 941193004544 dimerization interface [polypeptide binding]; other site 941193004545 ligand binding site [chemical binding]; other site 941193004546 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 941193004547 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 941193004548 active site 941193004549 phosphorylation site [posttranslational modification] 941193004550 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 941193004551 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 941193004552 dimerization domain swap beta strand [polypeptide binding]; other site 941193004553 regulatory protein interface [polypeptide binding]; other site 941193004554 active site 941193004555 regulatory phosphorylation site [posttranslational modification]; other site 941193004556 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 941193004557 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 941193004558 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 941193004559 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 941193004560 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 941193004561 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 941193004562 putative substrate binding site [chemical binding]; other site 941193004563 putative ATP binding site [chemical binding]; other site 941193004564 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 941193004565 active site 941193004566 P-loop; other site 941193004567 phosphorylation site [posttranslational modification] 941193004568 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 941193004569 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 941193004570 active site 941193004571 P-loop; other site 941193004572 phosphorylation site [posttranslational modification] 941193004573 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 941193004574 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 941193004575 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 941193004576 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 941193004577 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 941193004578 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 941193004579 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 941193004580 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 941193004581 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 941193004582 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 941193004583 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 941193004584 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 941193004585 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 941193004586 active site 941193004587 substrate binding site [chemical binding]; other site 941193004588 cosubstrate binding site; other site 941193004589 catalytic site [active] 941193004590 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 941193004591 active site 941193004592 hexamer interface [polypeptide binding]; other site 941193004593 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 941193004594 NAD binding site [chemical binding]; other site 941193004595 substrate binding site [chemical binding]; other site 941193004596 active site 941193004597 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 941193004598 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 941193004599 Ligand binding site; other site 941193004600 Putative Catalytic site; other site 941193004601 DXD motif; other site 941193004602 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 941193004603 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 941193004604 inhibitor-cofactor binding pocket; inhibition site 941193004605 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193004606 catalytic residue [active] 941193004607 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 941193004608 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 941193004609 Substrate binding site; other site 941193004610 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 941193004611 Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182 941193004612 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 941193004613 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cd00244 941193004614 active site 941193004615 Right handed beta helix region; Region: Beta_helix; pfam13229 941193004616 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 941193004617 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 941193004618 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 941193004619 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 941193004620 Sel1-like repeats; Region: SEL1; smart00671 941193004621 PilZ domain; Region: PilZ; pfam07238 941193004622 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193004623 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 941193004624 active site 941193004625 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 941193004626 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 941193004627 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 941193004628 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 941193004629 hypothetical protein; Validated; Region: PRK02101 941193004630 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 941193004631 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 941193004632 Walker A/P-loop; other site 941193004633 ATP binding site [chemical binding]; other site 941193004634 Q-loop/lid; other site 941193004635 ABC transporter signature motif; other site 941193004636 Walker B; other site 941193004637 D-loop; other site 941193004638 H-loop/switch region; other site 941193004639 TOBE domain; Region: TOBE_2; pfam08402 941193004640 ornithine carbamoyltransferase; Provisional; Region: PRK00779 941193004641 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 941193004642 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 941193004643 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 941193004644 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 941193004645 catalytic triad [active] 941193004646 putative active site [active] 941193004647 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 941193004648 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 941193004649 Autotransporter beta-domain; Region: Autotransporter; smart00869 941193004650 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 941193004651 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 941193004652 putative [Fe4-S4] binding site [ion binding]; other site 941193004653 putative molybdopterin cofactor binding site [chemical binding]; other site 941193004654 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 941193004655 putative molybdopterin cofactor binding site; other site 941193004656 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 941193004657 putative GSH binding site [chemical binding]; other site 941193004658 catalytic residues [active] 941193004659 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941193004660 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 941193004661 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 941193004662 heme binding site [chemical binding]; other site 941193004663 ferroxidase pore; other site 941193004664 ferroxidase diiron center [ion binding]; other site 941193004665 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 941193004666 peroxidase; Provisional; Region: PRK15000 941193004667 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 941193004668 dimer interface [polypeptide binding]; other site 941193004669 decamer (pentamer of dimers) interface [polypeptide binding]; other site 941193004670 catalytic triad [active] 941193004671 peroxidatic and resolving cysteines [active] 941193004672 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 941193004673 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 941193004674 dimer interface [polypeptide binding]; other site 941193004675 catalytic site [active] 941193004676 putative active site [active] 941193004677 putative substrate binding site [chemical binding]; other site 941193004678 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 941193004679 active site 941193004680 substrate binding pocket [chemical binding]; other site 941193004681 dimer interface [polypeptide binding]; other site 941193004682 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 941193004683 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 941193004684 ligand binding site [chemical binding]; other site 941193004685 argininosuccinate synthase; Provisional; Region: PRK13820 941193004686 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 941193004687 ANP binding site [chemical binding]; other site 941193004688 Substrate Binding Site II [chemical binding]; other site 941193004689 Substrate Binding Site I [chemical binding]; other site 941193004690 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941193004691 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 941193004692 dimer interface [polypeptide binding]; other site 941193004693 active site 941193004694 metal binding site [ion binding]; metal-binding site 941193004695 glutathione binding site [chemical binding]; other site 941193004696 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 941193004697 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193004698 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193004699 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 941193004700 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 941193004701 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941193004702 metal-binding site [ion binding] 941193004703 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 941193004704 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 941193004705 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 941193004706 tetramer interface [polypeptide binding]; other site 941193004707 active site 941193004708 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 941193004709 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 941193004710 tetramer interface [polypeptide binding]; other site 941193004711 active site 941193004712 Methyltransferase domain; Region: Methyltransf_31; pfam13847 941193004713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193004714 S-adenosylmethionine binding site [chemical binding]; other site 941193004715 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 941193004716 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 941193004717 minor groove reading motif; other site 941193004718 helix-hairpin-helix signature motif; other site 941193004719 substrate binding pocket [chemical binding]; other site 941193004720 active site 941193004721 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 941193004722 electron transport complex RsxE subunit; Provisional; Region: PRK12405 941193004723 Predicted NADH:ubiquinone oxidoreductase, subunit RnfG [Energy production and conversion]; Region: RnfG; COG4659 941193004724 electron transport complex, RnfABCDGE type, D subunit; Region: rnfD; TIGR01946 941193004725 electron transport complex protein RnfC; Provisional; Region: PRK05035 941193004726 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 941193004727 SLBB domain; Region: SLBB; pfam10531 941193004728 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 941193004729 electron transport complex protein RnfB; Provisional; Region: PRK05113 941193004730 Putative Fe-S cluster; Region: FeS; pfam04060 941193004731 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 941193004732 electron transport complex protein RsxA; Provisional; Region: PRK05151 941193004733 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 941193004734 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 941193004735 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 941193004736 active site 941193004737 HIGH motif; other site 941193004738 KMSKS motif; other site 941193004739 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 941193004740 tRNA binding surface [nucleotide binding]; other site 941193004741 anticodon binding site; other site 941193004742 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 941193004743 putative tRNA-binding site [nucleotide binding]; other site 941193004744 dimer interface [polypeptide binding]; other site 941193004745 antiporter inner membrane protein; Provisional; Region: PRK11670 941193004746 Domain of unknown function DUF59; Region: DUF59; pfam01883 941193004747 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 941193004748 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 941193004749 trimer interface [polypeptide binding]; other site 941193004750 active site 941193004751 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 941193004752 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 941193004753 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 941193004754 homodimer interface [polypeptide binding]; other site 941193004755 active site 941193004756 TDP-binding site; other site 941193004757 acceptor substrate-binding pocket; other site 941193004758 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 941193004759 Autoinducer binding domain; Region: Autoind_bind; pfam03472 941193004760 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193004761 DNA binding residues [nucleotide binding] 941193004762 dimerization interface [polypeptide binding]; other site 941193004763 N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916 941193004764 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 941193004765 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193004766 substrate binding pocket [chemical binding]; other site 941193004767 membrane-bound complex binding site; other site 941193004768 hinge residues; other site 941193004769 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 941193004770 Predicted permeases [General function prediction only]; Region: RarD; COG2962 941193004771 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 941193004772 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 941193004773 NlpC/P60 family; Region: NLPC_P60; pfam00877 941193004774 malate dehydrogenase; Provisional; Region: PRK13529 941193004775 Malic enzyme, N-terminal domain; Region: malic; pfam00390 941193004776 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 941193004777 NAD(P) binding site [chemical binding]; other site 941193004778 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 941193004779 nudix motif; other site 941193004780 RibD C-terminal domain; Region: RibD_C; cl17279 941193004781 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 941193004782 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 941193004783 Mechanosensitive ion channel; Region: MS_channel; pfam00924 941193004784 benzoate transport; Region: 2A0115; TIGR00895 941193004785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193004786 putative substrate translocation pore; other site 941193004787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193004788 helicase 45; Provisional; Region: PTZ00424 941193004789 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 941193004790 ATP binding site [chemical binding]; other site 941193004791 Mg++ binding site [ion binding]; other site 941193004792 motif III; other site 941193004793 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941193004794 nucleotide binding region [chemical binding]; other site 941193004795 ATP-binding site [chemical binding]; other site 941193004796 Transmembrane secretion effector; Region: MFS_3; pfam05977 941193004797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193004798 putative substrate translocation pore; other site 941193004799 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 941193004800 hypothetical protein; Provisional; Region: PRK00304 941193004801 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 941193004802 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 941193004803 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 941193004804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193004805 dimer interface [polypeptide binding]; other site 941193004806 phosphorylation site [posttranslational modification] 941193004807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193004808 ATP binding site [chemical binding]; other site 941193004809 Mg2+ binding site [ion binding]; other site 941193004810 G-X-G motif; other site 941193004811 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 941193004812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193004813 active site 941193004814 phosphorylation site [posttranslational modification] 941193004815 intermolecular recognition site; other site 941193004816 dimerization interface [polypeptide binding]; other site 941193004817 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 941193004818 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 941193004819 putative oligomer interface [polypeptide binding]; other site 941193004820 putative active site [active] 941193004821 metal binding site [ion binding]; metal-binding site 941193004822 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 941193004823 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 941193004824 ATP-grasp domain; Region: ATP-grasp_4; cl17255 941193004825 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 941193004826 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 941193004827 active site 941193004828 dimer interface [polypeptide binding]; other site 941193004829 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 941193004830 Ligand Binding Site [chemical binding]; other site 941193004831 Molecular Tunnel; other site 941193004832 MarR family; Region: MarR_2; cl17246 941193004833 Predicted permeases [General function prediction only]; Region: COG0730 941193004834 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 941193004835 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 941193004836 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 941193004837 Uncharacterized conserved protein [Function unknown]; Region: COG2326 941193004838 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 941193004839 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 941193004840 dimer interface [polypeptide binding]; other site 941193004841 active site 941193004842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 941193004843 malate:quinone oxidoreductase; Validated; Region: PRK05257 941193004844 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 941193004845 Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607 941193004846 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 941193004847 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 941193004848 dimer interface [polypeptide binding]; other site 941193004849 decamer (pentamer of dimers) interface [polypeptide binding]; other site 941193004850 catalytic triad [active] 941193004851 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 941193004852 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193004853 substrate binding pocket [chemical binding]; other site 941193004854 membrane-bound complex binding site; other site 941193004855 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 941193004856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193004857 dimer interface [polypeptide binding]; other site 941193004858 conserved gate region; other site 941193004859 putative PBP binding loops; other site 941193004860 ABC-ATPase subunit interface; other site 941193004861 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 941193004862 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 941193004863 Walker A/P-loop; other site 941193004864 ATP binding site [chemical binding]; other site 941193004865 Q-loop/lid; other site 941193004866 ABC transporter signature motif; other site 941193004867 Walker B; other site 941193004868 D-loop; other site 941193004869 H-loop/switch region; other site 941193004870 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 941193004871 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941193004872 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 941193004873 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193004874 substrate binding pocket [chemical binding]; other site 941193004875 membrane-bound complex binding site; other site 941193004876 hinge residues; other site 941193004877 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 941193004878 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 941193004879 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 941193004880 active site 941193004881 dimer interface [polypeptide binding]; other site 941193004882 non-prolyl cis peptide bond; other site 941193004883 insertion regions; other site 941193004884 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 941193004885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193004886 dimer interface [polypeptide binding]; other site 941193004887 conserved gate region; other site 941193004888 putative PBP binding loops; other site 941193004889 ABC-ATPase subunit interface; other site 941193004890 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 941193004891 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193004892 Walker A/P-loop; other site 941193004893 ATP binding site [chemical binding]; other site 941193004894 Q-loop/lid; other site 941193004895 ABC transporter signature motif; other site 941193004896 Walker B; other site 941193004897 D-loop; other site 941193004898 H-loop/switch region; other site 941193004899 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 941193004900 HopJ type III effector protein; Region: HopJ; pfam08888 941193004901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 941193004902 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 941193004903 homooctamer interface [polypeptide binding]; other site 941193004904 active site 941193004905 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 941193004906 homodecamer interface [polypeptide binding]; other site 941193004907 GTP cyclohydrolase I; Provisional; Region: PLN03044 941193004908 active site 941193004909 putative catalytic site residues [active] 941193004910 zinc binding site [ion binding]; other site 941193004911 GTP-CH-I/GFRP interaction surface; other site 941193004912 dihydromonapterin reductase; Provisional; Region: PRK06483 941193004913 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193004914 NAD(P) binding site [chemical binding]; other site 941193004915 active site 941193004916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 941193004917 flavodoxin; Provisional; Region: PRK05723 941193004918 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193004919 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193004920 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 941193004921 putative dimerization interface [polypeptide binding]; other site 941193004922 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 941193004923 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 941193004924 aldolase II superfamily protein; Provisional; Region: PRK07044 941193004925 intersubunit interface [polypeptide binding]; other site 941193004926 active site 941193004927 Zn2+ binding site [ion binding]; other site 941193004928 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 941193004929 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 941193004930 homodimer interface [polypeptide binding]; other site 941193004931 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 941193004932 NAD binding site [chemical binding]; other site 941193004933 active site 941193004934 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 941193004935 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941193004936 substrate binding site [chemical binding]; other site 941193004937 oxyanion hole (OAH) forming residues; other site 941193004938 trimer interface [polypeptide binding]; other site 941193004939 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 941193004940 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 941193004941 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 941193004942 SnoaL-like domain; Region: SnoaL_2; pfam12680 941193004943 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941193004944 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193004945 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 941193004946 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 941193004947 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 941193004948 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193004949 DNA binding residues [nucleotide binding] 941193004950 dimerization interface [polypeptide binding]; other site 941193004951 Uncharacterized conserved protein [Function unknown]; Region: COG2912 941193004952 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 941193004953 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 941193004954 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 941193004955 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 941193004956 NAD binding site [chemical binding]; other site 941193004957 Phe binding site; other site 941193004958 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 941193004959 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 941193004960 TPP-binding site [chemical binding]; other site 941193004961 tetramer interface [polypeptide binding]; other site 941193004962 heterodimer interface [polypeptide binding]; other site 941193004963 phosphorylation loop region [posttranslational modification] 941193004964 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 941193004965 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 941193004966 alpha subunit interface [polypeptide binding]; other site 941193004967 TPP binding site [chemical binding]; other site 941193004968 heterodimer interface [polypeptide binding]; other site 941193004969 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 941193004970 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 941193004971 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 941193004972 E3 interaction surface; other site 941193004973 lipoyl attachment site [posttranslational modification]; other site 941193004974 e3 binding domain; Region: E3_binding; pfam02817 941193004975 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 941193004976 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 941193004977 DNA damage-inducible gene in SOS regulon, dependent on cyclic AMP and H-NS , pqiA [General function prediction only]; Region: COG3141 941193004978 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 941193004979 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 941193004980 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941193004981 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941193004982 DNA binding residues [nucleotide binding] 941193004983 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 941193004984 FecR protein; Region: FecR; pfam04773 941193004985 Secretin and TonB N terminus short domain; Region: STN; smart00965 941193004986 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 941193004987 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193004988 N-terminal plug; other site 941193004989 ligand-binding site [chemical binding]; other site 941193004990 Heme-binding protein A (HasA); Region: HasA; pfam06438 941193004991 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 941193004992 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 941193004993 Walker A/P-loop; other site 941193004994 ATP binding site [chemical binding]; other site 941193004995 Q-loop/lid; other site 941193004996 ABC transporter signature motif; other site 941193004997 Walker B; other site 941193004998 D-loop; other site 941193004999 H-loop/switch region; other site 941193005000 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 941193005001 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193005002 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193005003 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 941193005004 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 941193005005 Predicted membrane protein [Function unknown]; Region: COG3223 941193005006 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193005007 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193005008 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 941193005009 ABC-2 type transporter; Region: ABC2_membrane; cl17235 941193005010 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 941193005011 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 941193005012 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 941193005013 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 941193005014 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 941193005015 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193005016 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 941193005017 putative dimerization interface [polypeptide binding]; other site 941193005018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 941193005019 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 941193005020 FAD binding pocket [chemical binding]; other site 941193005021 FAD binding motif [chemical binding]; other site 941193005022 phosphate binding motif [ion binding]; other site 941193005023 beta-alpha-beta structure motif; other site 941193005024 NAD binding pocket [chemical binding]; other site 941193005025 NosL; Region: NosL; cl01769 941193005026 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 941193005027 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941193005028 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 941193005029 Walker A/P-loop; other site 941193005030 ATP binding site [chemical binding]; other site 941193005031 Q-loop/lid; other site 941193005032 ABC transporter signature motif; other site 941193005033 Walker B; other site 941193005034 D-loop; other site 941193005035 H-loop/switch region; other site 941193005036 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 941193005037 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 941193005038 nitrous-oxide reductase; Validated; Region: PRK02888 941193005039 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 941193005040 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 941193005041 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 941193005042 4Fe-4S binding domain; Region: Fer4_5; pfam12801 941193005043 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 941193005044 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941193005045 active site 941193005046 metal binding site [ion binding]; metal-binding site 941193005047 Uncharacterized conserved protein [Function unknown]; Region: COG1359 941193005048 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 941193005049 homodimer interaction site [polypeptide binding]; other site 941193005050 cofactor binding site; other site 941193005051 RhlG and related beta-ketoacyl reductases, classical (c) SDRs; Region: RhlG_SDR_c; cd08942 941193005052 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 941193005053 NADP binding site [chemical binding]; other site 941193005054 active site 941193005055 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 941193005056 Arc-like DNA binding domain; Region: Arc; pfam03869 941193005057 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 941193005058 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 941193005059 Walker A/P-loop; other site 941193005060 ATP binding site [chemical binding]; other site 941193005061 Q-loop/lid; other site 941193005062 ABC transporter signature motif; other site 941193005063 Walker B; other site 941193005064 D-loop; other site 941193005065 H-loop/switch region; other site 941193005066 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 941193005067 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 941193005068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193005069 dimer interface [polypeptide binding]; other site 941193005070 conserved gate region; other site 941193005071 ABC-ATPase subunit interface; other site 941193005072 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 941193005073 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193005074 DNA-binding site [nucleotide binding]; DNA binding site 941193005075 UTRA domain; Region: UTRA; pfam07702 941193005076 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 941193005077 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 941193005078 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 941193005079 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 941193005080 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 941193005081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193005082 Walker A/P-loop; other site 941193005083 ATP binding site [chemical binding]; other site 941193005084 Q-loop/lid; other site 941193005085 ABC transporter signature motif; other site 941193005086 Walker B; other site 941193005087 D-loop; other site 941193005088 H-loop/switch region; other site 941193005089 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 941193005090 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 941193005091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193005092 Walker A/P-loop; other site 941193005093 ATP binding site [chemical binding]; other site 941193005094 Q-loop/lid; other site 941193005095 ABC transporter signature motif; other site 941193005096 Walker B; other site 941193005097 D-loop; other site 941193005098 H-loop/switch region; other site 941193005099 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 941193005100 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 941193005101 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 941193005102 active site 941193005103 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 941193005104 active site 941193005105 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 941193005106 putative hydrolase; Provisional; Region: PRK02113 941193005107 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 941193005108 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 941193005109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941193005110 Coenzyme A binding pocket [chemical binding]; other site 941193005111 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 941193005112 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 941193005113 multimer interface [polypeptide binding]; other site 941193005114 active site 941193005115 catalytic triad [active] 941193005116 dimer interface [polypeptide binding]; other site 941193005117 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 941193005118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193005119 Walker A motif; other site 941193005120 ATP binding site [chemical binding]; other site 941193005121 Walker B motif; other site 941193005122 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 941193005123 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 941193005124 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 941193005125 ligand binding site [chemical binding]; other site 941193005126 regulator interaction site; other site 941193005127 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 941193005128 ANTAR domain; Region: ANTAR; pfam03861 941193005129 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 941193005130 Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472 941193005131 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 941193005132 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193005133 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193005134 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 941193005135 EamA-like transporter family; Region: EamA; cl17759 941193005136 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 941193005137 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 941193005138 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941193005139 catalytic residue [active] 941193005140 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 941193005141 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 941193005142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193005143 putative substrate translocation pore; other site 941193005144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 941193005145 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 941193005146 Flagellar regulator YcgR; Region: YcgR; pfam07317 941193005147 PilZ domain; Region: PilZ; pfam07238 941193005148 Flagellar biosynthesis/type III secretory pathway chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3418 941193005149 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 941193005150 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 941193005151 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 941193005152 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 941193005153 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 941193005154 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 941193005155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193005156 active site 941193005157 phosphorylation site [posttranslational modification] 941193005158 intermolecular recognition site; other site 941193005159 dimerization interface [polypeptide binding]; other site 941193005160 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 941193005161 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 941193005162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193005163 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 941193005164 anti sigma factor interaction site; other site 941193005165 regulatory phosphorylation site [posttranslational modification]; other site 941193005166 Response regulator receiver domain; Region: Response_reg; pfam00072 941193005167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193005168 active site 941193005169 phosphorylation site [posttranslational modification] 941193005170 intermolecular recognition site; other site 941193005171 dimerization interface [polypeptide binding]; other site 941193005172 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 941193005173 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 941193005174 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 941193005175 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 941193005176 putative binding surface; other site 941193005177 active site 941193005178 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 941193005179 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941193005180 ATP binding site [chemical binding]; other site 941193005181 putative Mg++ binding site [ion binding]; other site 941193005182 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941193005183 nucleotide binding region [chemical binding]; other site 941193005184 ATP-binding site [chemical binding]; other site 941193005185 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 941193005186 HRDC domain; Region: HRDC; pfam00570 941193005187 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193005188 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193005189 metal binding site [ion binding]; metal-binding site 941193005190 active site 941193005191 I-site; other site 941193005192 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 941193005193 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941193005194 MarR family; Region: MarR_2; pfam12802 941193005195 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 941193005196 FimV N-terminal domain; Region: FimV_core; TIGR03505 941193005197 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 941193005198 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 941193005199 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 941193005200 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 941193005201 active site 941193005202 nucleophile elbow; other site 941193005203 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 941193005204 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 941193005205 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 941193005206 Surface antigen; Region: Bac_surface_Ag; pfam01103 941193005207 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 941193005208 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 941193005209 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 941193005210 NADP binding site [chemical binding]; other site 941193005211 homopentamer interface [polypeptide binding]; other site 941193005212 substrate binding site [chemical binding]; other site 941193005213 active site 941193005214 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 941193005215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193005216 putative substrate translocation pore; other site 941193005217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193005218 S-adenosylmethionine binding site [chemical binding]; other site 941193005219 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 941193005220 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 941193005221 dimer interface [polypeptide binding]; other site 941193005222 active site 941193005223 CoA binding pocket [chemical binding]; other site 941193005224 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 941193005225 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 941193005226 Cytochrome P450; Region: p450; cl12078 941193005227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193005228 short chain dehydrogenase; Provisional; Region: PRK06914 941193005229 NAD(P) binding site [chemical binding]; other site 941193005230 active site 941193005231 Condensation domain; Region: Condensation; pfam00668 941193005232 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 941193005233 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 941193005234 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 941193005235 Condensation domain; Region: Condensation; pfam00668 941193005236 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 941193005237 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 941193005238 acyl-activating enzyme (AAE) consensus motif; other site 941193005239 AMP binding site [chemical binding]; other site 941193005240 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941193005241 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 941193005242 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 941193005243 acyl-activating enzyme (AAE) consensus motif; other site 941193005244 AMP binding site [chemical binding]; other site 941193005245 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941193005246 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 941193005247 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 941193005248 oligomer interface [polypeptide binding]; other site 941193005249 active site residues [active] 941193005250 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 941193005251 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 941193005252 short chain dehydrogenase; Validated; Region: PRK05855 941193005253 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 941193005254 classical (c) SDRs; Region: SDR_c; cd05233 941193005255 NAD(P) binding site [chemical binding]; other site 941193005256 active site 941193005257 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 941193005258 active site 941193005259 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 941193005260 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 941193005261 DNA binding residues [nucleotide binding] 941193005262 putative dimer interface [polypeptide binding]; other site 941193005263 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193005264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193005265 The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465 941193005266 putative substrate binding pocket [chemical binding]; other site 941193005267 putative dimerization interface [polypeptide binding]; other site 941193005268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 941193005269 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 941193005270 Phosphoesterase family; Region: Phosphoesterase; pfam04185 941193005271 Domain of unknown function (DUF756); Region: DUF756; pfam05506 941193005272 Domain of unknown function (DUF756); Region: DUF756; pfam05506 941193005273 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 941193005274 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 941193005275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 941193005276 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 941193005277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193005278 Walker A/P-loop; other site 941193005279 ATP binding site [chemical binding]; other site 941193005280 Q-loop/lid; other site 941193005281 ABC transporter signature motif; other site 941193005282 Walker B; other site 941193005283 D-loop; other site 941193005284 H-loop/switch region; other site 941193005285 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 941193005286 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193005287 substrate binding pocket [chemical binding]; other site 941193005288 membrane-bound complex binding site; other site 941193005289 hinge residues; other site 941193005290 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 941193005291 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 941193005292 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 941193005293 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 941193005294 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 941193005295 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193005296 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193005297 metal binding site [ion binding]; metal-binding site 941193005298 active site 941193005299 I-site; other site 941193005300 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941193005301 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 941193005302 Sulfatase; Region: Sulfatase; pfam00884 941193005303 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 941193005304 Ligand Binding Site [chemical binding]; other site 941193005305 ATP-dependent helicase HepA; Validated; Region: PRK04914 941193005306 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941193005307 ATP binding site [chemical binding]; other site 941193005308 putative Mg++ binding site [ion binding]; other site 941193005309 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941193005310 nucleotide binding region [chemical binding]; other site 941193005311 ATP-binding site [chemical binding]; other site 941193005312 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 941193005313 Fusaric acid resistance protein family; Region: FUSC; pfam04632 941193005314 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 941193005315 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 941193005316 HlyD family secretion protein; Region: HlyD; pfam00529 941193005317 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193005318 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193005319 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 941193005320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 941193005321 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 941193005322 dimer interaction site [polypeptide binding]; other site 941193005323 substrate-binding tunnel; other site 941193005324 active site 941193005325 catalytic site [active] 941193005326 substrate binding site [chemical binding]; other site 941193005327 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 941193005328 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 941193005329 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 941193005330 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492 941193005331 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 941193005332 acyl-activating enzyme (AAE) consensus motif; other site 941193005333 putative AMP binding site [chemical binding]; other site 941193005334 putative active site [active] 941193005335 putative CoA binding site [chemical binding]; other site 941193005336 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 941193005337 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 941193005338 acyl-activating enzyme (AAE) consensus motif; other site 941193005339 putative AMP binding site [chemical binding]; other site 941193005340 putative active site [active] 941193005341 putative CoA binding site [chemical binding]; other site 941193005342 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 941193005343 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941193005344 ATP binding site [chemical binding]; other site 941193005345 putative Mg++ binding site [ion binding]; other site 941193005346 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941193005347 nucleotide binding region [chemical binding]; other site 941193005348 ATP-binding site [chemical binding]; other site 941193005349 Helicase associated domain (HA2); Region: HA2; pfam04408 941193005350 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 941193005351 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 941193005352 alkaline phosphatase; Provisional; Region: PRK10518 941193005353 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 941193005354 active site 941193005355 dimer interface [polypeptide binding]; other site 941193005356 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 941193005357 HIT family signature motif; other site 941193005358 catalytic residue [active] 941193005359 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 941193005360 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 941193005361 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 941193005362 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 941193005363 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 941193005364 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 941193005365 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 941193005366 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 941193005367 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 941193005368 Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335 941193005369 Isochorismatase family; Region: Isochorismatase; pfam00857 941193005370 catalytic triad [active] 941193005371 conserved cis-peptide bond; other site 941193005372 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 941193005373 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 941193005374 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 941193005375 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 941193005376 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 941193005377 dimer interface [polypeptide binding]; other site 941193005378 active site 941193005379 CoA binding pocket [chemical binding]; other site 941193005380 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 941193005381 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941193005382 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941193005383 DNA binding residues [nucleotide binding] 941193005384 Putative zinc-finger; Region: zf-HC2; pfam13490 941193005385 Uncharacterized low-complexity protein [Function unknown]; Region: COG3767 941193005386 Protein of unknown function (DUF692); Region: DUF692; pfam05114 941193005387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3219 941193005388 Predicted membrane protein [Function unknown]; Region: COG2259 941193005389 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 941193005390 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 941193005391 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 941193005392 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 941193005393 short chain dehydrogenase; Provisional; Region: PRK05650 941193005394 classical (c) SDRs; Region: SDR_c; cd05233 941193005395 NAD(P) binding site [chemical binding]; other site 941193005396 active site 941193005397 Uncharacterized conserved protein [Function unknown]; Region: COG1742 941193005398 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 941193005399 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941193005400 ATP binding site [chemical binding]; other site 941193005401 putative Mg++ binding site [ion binding]; other site 941193005402 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941193005403 nucleotide binding region [chemical binding]; other site 941193005404 ATP-binding site [chemical binding]; other site 941193005405 DEAD/H associated; Region: DEAD_assoc; pfam08494 941193005406 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 941193005407 Na binding site [ion binding]; other site 941193005408 PAS fold; Region: PAS_7; pfam12860 941193005409 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941193005410 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193005411 dimer interface [polypeptide binding]; other site 941193005412 phosphorylation site [posttranslational modification] 941193005413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193005414 ATP binding site [chemical binding]; other site 941193005415 Mg2+ binding site [ion binding]; other site 941193005416 G-X-G motif; other site 941193005417 Response regulator receiver domain; Region: Response_reg; pfam00072 941193005418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193005419 active site 941193005420 phosphorylation site [posttranslational modification] 941193005421 intermolecular recognition site; other site 941193005422 dimerization interface [polypeptide binding]; other site 941193005423 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 941193005424 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 941193005425 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 941193005426 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941193005427 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193005428 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193005429 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 941193005430 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193005431 N-terminal plug; other site 941193005432 ligand-binding site [chemical binding]; other site 941193005433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193005434 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941193005435 putative substrate translocation pore; other site 941193005436 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 941193005437 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 941193005438 putative acyl-acceptor binding pocket; other site 941193005439 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 941193005440 DNA-binding site [nucleotide binding]; DNA binding site 941193005441 RNA-binding motif; other site 941193005442 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 941193005443 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 941193005444 Sodium Bile acid symporter family; Region: SBF; pfam01758 941193005445 recombination associated protein; Reviewed; Region: rdgC; PRK00321 941193005446 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 941193005447 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 941193005448 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 941193005449 Uncharacterized conserved protein [Function unknown]; Region: COG3339 941193005450 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 941193005451 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193005452 substrate binding pocket [chemical binding]; other site 941193005453 membrane-bound complex binding site; other site 941193005454 hinge residues; other site 941193005455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941193005456 non-specific DNA binding site [nucleotide binding]; other site 941193005457 salt bridge; other site 941193005458 sequence-specific DNA binding site [nucleotide binding]; other site 941193005459 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941193005460 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 941193005461 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193005462 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193005463 metal binding site [ion binding]; metal-binding site 941193005464 active site 941193005465 I-site; other site 941193005466 carboxy-terminal protease; Provisional; Region: PRK11186 941193005467 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 941193005468 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 941193005469 protein binding site [polypeptide binding]; other site 941193005470 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 941193005471 Catalytic dyad [active] 941193005472 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 941193005473 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 941193005474 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 941193005475 NAD(P) binding site [chemical binding]; other site 941193005476 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 941193005477 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 941193005478 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 941193005479 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193005480 Walker A/P-loop; other site 941193005481 ATP binding site [chemical binding]; other site 941193005482 Q-loop/lid; other site 941193005483 ABC transporter signature motif; other site 941193005484 Walker B; other site 941193005485 D-loop; other site 941193005486 H-loop/switch region; other site 941193005487 TOBE domain; Region: TOBE_2; pfam08402 941193005488 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 941193005489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193005490 dimer interface [polypeptide binding]; other site 941193005491 conserved gate region; other site 941193005492 putative PBP binding loops; other site 941193005493 ABC-ATPase subunit interface; other site 941193005494 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 941193005495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193005496 dimer interface [polypeptide binding]; other site 941193005497 conserved gate region; other site 941193005498 putative PBP binding loops; other site 941193005499 ABC-ATPase subunit interface; other site 941193005500 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 941193005501 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 941193005502 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 941193005503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193005504 DNA-binding site [nucleotide binding]; DNA binding site 941193005505 transcriptional regulator protein; Region: phnR; TIGR03337 941193005506 UTRA domain; Region: UTRA; pfam07702 941193005507 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 941193005508 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 941193005509 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 941193005510 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 941193005511 active site 941193005512 metal binding site [ion binding]; metal-binding site 941193005513 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 941193005514 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 941193005515 active site 941193005516 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 941193005517 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 941193005518 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 941193005519 Switch I; other site 941193005520 Switch II; other site 941193005521 septum formation inhibitor; Reviewed; Region: minC; PRK00339 941193005522 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 941193005523 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 941193005524 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 941193005525 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 941193005526 putative acyl-acceptor binding pocket; other site 941193005527 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 941193005528 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 941193005529 active site 941193005530 nucleophile elbow; other site 941193005531 Pirin-related protein [General function prediction only]; Region: COG1741 941193005532 Pirin; Region: Pirin; pfam02678 941193005533 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 941193005534 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 941193005535 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 941193005536 Predicted membrane protein [Function unknown]; Region: COG3205 941193005537 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 941193005538 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 941193005539 Predicted membrane protein [Function unknown]; Region: COG3162 941193005540 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 941193005541 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 941193005542 Na binding site [ion binding]; other site 941193005543 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 941193005544 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 941193005545 ligand binding site [chemical binding]; other site 941193005546 flexible hinge region; other site 941193005547 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain. Members of CAP_ED, include CAP...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589 941193005548 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 941193005549 metal binding triad; other site 941193005550 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 941193005551 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 941193005552 active site 941193005553 catalytic site [active] 941193005554 substrate binding site [chemical binding]; other site 941193005555 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 941193005556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 941193005557 Protein of unknown function, DUF482; Region: DUF482; pfam04339 941193005558 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 941193005559 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941193005560 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941193005561 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 941193005562 Walker A/P-loop; other site 941193005563 ATP binding site [chemical binding]; other site 941193005564 Q-loop/lid; other site 941193005565 ABC transporter signature motif; other site 941193005566 Walker B; other site 941193005567 D-loop; other site 941193005568 H-loop/switch region; other site 941193005569 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 941193005570 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 941193005571 substrate binding site [chemical binding]; other site 941193005572 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 941193005573 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 941193005574 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 941193005575 catalytic site [active] 941193005576 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193005577 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193005578 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193005579 dimerization interface [polypeptide binding]; other site 941193005580 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 941193005581 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941193005582 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 941193005583 EamA-like transporter family; Region: EamA; pfam00892 941193005584 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 941193005585 dimer interface [polypeptide binding]; other site 941193005586 putative tRNA-binding site [nucleotide binding]; other site 941193005587 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193005588 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941193005589 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193005590 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 941193005591 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 941193005592 putative active site [active] 941193005593 putative metal binding site [ion binding]; other site 941193005594 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941193005595 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 941193005596 MASE2 domain; Region: MASE2; pfam05230 941193005597 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 941193005598 cyclase homology domain; Region: CHD; cd07302 941193005599 nucleotidyl binding site; other site 941193005600 metal binding site [ion binding]; metal-binding site 941193005601 dimer interface [polypeptide binding]; other site 941193005602 Predicted membrane protein [Function unknown]; Region: COG4323 941193005603 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 941193005604 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941193005605 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193005606 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 941193005607 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 941193005608 mce related protein; Region: MCE; pfam02470 941193005609 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 941193005610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193005611 Walker A/P-loop; other site 941193005612 ATP binding site [chemical binding]; other site 941193005613 Q-loop/lid; other site 941193005614 ABC transporter signature motif; other site 941193005615 Walker B; other site 941193005616 D-loop; other site 941193005617 H-loop/switch region; other site 941193005618 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 941193005619 Permease; Region: Permease; pfam02405 941193005620 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 941193005621 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 941193005622 Flagellin N-methylase; Region: FliB; cl00497 941193005623 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 941193005624 putative FMN binding site [chemical binding]; other site 941193005625 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941193005626 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193005627 dimerization interface [polypeptide binding]; other site 941193005628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193005629 ATP binding site [chemical binding]; other site 941193005630 Mg2+ binding site [ion binding]; other site 941193005631 G-X-G motif; other site 941193005632 P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein [Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism]; Region: CpxP; COG3678 941193005633 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941193005634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193005635 active site 941193005636 phosphorylation site [posttranslational modification] 941193005637 intermolecular recognition site; other site 941193005638 dimerization interface [polypeptide binding]; other site 941193005639 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193005640 DNA binding site [nucleotide binding] 941193005641 YciI-like protein; Reviewed; Region: PRK11370 941193005642 intracellular septation protein A; Reviewed; Region: PRK00259 941193005643 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 941193005644 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 941193005645 active site 941193005646 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 941193005647 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 941193005648 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 941193005649 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 941193005650 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 941193005651 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 941193005652 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 941193005653 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 941193005654 phosphogluconate dehydratase; Validated; Region: PRK09054 941193005655 6-phosphogluconate dehydratase; Region: edd; TIGR01196 941193005656 glucokinase, proteobacterial type; Region: glk; TIGR00749 941193005657 glucokinase; Provisional; Region: glk; PRK00292 941193005658 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941193005659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193005660 active site 941193005661 phosphorylation site [posttranslational modification] 941193005662 intermolecular recognition site; other site 941193005663 dimerization interface [polypeptide binding]; other site 941193005664 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193005665 DNA binding site [nucleotide binding] 941193005666 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 941193005667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193005668 ATP binding site [chemical binding]; other site 941193005669 Mg2+ binding site [ion binding]; other site 941193005670 G-X-G motif; other site 941193005671 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 941193005672 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 941193005673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193005674 dimer interface [polypeptide binding]; other site 941193005675 conserved gate region; other site 941193005676 putative PBP binding loops; other site 941193005677 ABC-ATPase subunit interface; other site 941193005678 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 941193005679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193005680 dimer interface [polypeptide binding]; other site 941193005681 conserved gate region; other site 941193005682 putative PBP binding loops; other site 941193005683 ABC-ATPase subunit interface; other site 941193005684 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 941193005685 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 941193005686 Walker A/P-loop; other site 941193005687 ATP binding site [chemical binding]; other site 941193005688 Q-loop/lid; other site 941193005689 ABC transporter signature motif; other site 941193005690 Walker B; other site 941193005691 D-loop; other site 941193005692 H-loop/switch region; other site 941193005693 TOBE domain; Region: TOBE; pfam03459 941193005694 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 941193005695 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 941193005696 active site 941193005697 phosphate binding residues; other site 941193005698 catalytic residues [active] 941193005699 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 941193005700 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 941193005701 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 941193005702 putative active site [active] 941193005703 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 941193005704 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 941193005705 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 941193005706 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 941193005707 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 941193005708 putative active site [active] 941193005709 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 941193005710 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 941193005711 active site 941193005712 intersubunit interface [polypeptide binding]; other site 941193005713 catalytic residue [active] 941193005714 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 941193005715 nudix motif; other site 941193005716 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 941193005717 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941193005718 RNA binding surface [nucleotide binding]; other site 941193005719 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 941193005720 probable active site [active] 941193005721 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193005722 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193005723 metal binding site [ion binding]; metal-binding site 941193005724 active site 941193005725 I-site; other site 941193005726 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 941193005727 agmatinase; Region: agmatinase; TIGR01230 941193005728 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 941193005729 putative active site [active] 941193005730 putative metal binding site [ion binding]; other site 941193005731 Transcriptional regulator [Transcription]; Region: IclR; COG1414 941193005732 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 941193005733 Bacterial transcriptional regulator; Region: IclR; pfam01614 941193005734 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 941193005735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193005736 NAD(P) binding site [chemical binding]; other site 941193005737 active site 941193005738 phosphoglycolate phosphatase; Provisional; Region: PRK13222 941193005739 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941193005740 motif II; other site 941193005741 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 941193005742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193005743 S-adenosylmethionine binding site [chemical binding]; other site 941193005744 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 941193005745 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 941193005746 active site 941193005747 putative substrate binding pocket [chemical binding]; other site 941193005748 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 941193005749 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 941193005750 DNA gyrase subunit A; Validated; Region: PRK05560 941193005751 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 941193005752 CAP-like domain; other site 941193005753 active site 941193005754 primary dimer interface [polypeptide binding]; other site 941193005755 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941193005756 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941193005757 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941193005758 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941193005759 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941193005760 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941193005761 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 941193005762 homodimer interface [polypeptide binding]; other site 941193005763 substrate-cofactor binding pocket; other site 941193005764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193005765 catalytic residue [active] 941193005766 Chorismate mutase type II; Region: CM_2; cl00693 941193005767 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 941193005768 Prephenate dehydratase; Region: PDT; pfam00800 941193005769 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 941193005770 putative L-Phe binding site [chemical binding]; other site 941193005771 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 941193005772 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941193005773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193005774 homodimer interface [polypeptide binding]; other site 941193005775 catalytic residue [active] 941193005776 cytidylate kinase; Provisional; Region: cmk; PRK00023 941193005777 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 941193005778 CMP-binding site; other site 941193005779 The sites determining sugar specificity; other site 941193005780 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 941193005781 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 941193005782 RNA binding site [nucleotide binding]; other site 941193005783 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 941193005784 RNA binding site [nucleotide binding]; other site 941193005785 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 941193005786 RNA binding site [nucleotide binding]; other site 941193005787 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 941193005788 RNA binding site [nucleotide binding]; other site 941193005789 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 941193005790 RNA binding site [nucleotide binding]; other site 941193005791 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 941193005792 RNA binding site [nucleotide binding]; other site 941193005793 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 941193005794 IHF dimer interface [polypeptide binding]; other site 941193005795 IHF - DNA interface [nucleotide binding]; other site 941193005796 Chain length determinant protein; Region: Wzz; pfam02706 941193005797 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 941193005798 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 941193005799 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 941193005800 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 941193005801 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 941193005802 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 941193005803 NAD binding site [chemical binding]; other site 941193005804 substrate binding site [chemical binding]; other site 941193005805 homodimer interface [polypeptide binding]; other site 941193005806 active site 941193005807 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 941193005808 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 941193005809 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941193005810 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 941193005811 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 941193005812 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 941193005813 active site 941193005814 dimer interface [polypeptide binding]; other site 941193005815 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 941193005816 Ligand Binding Site [chemical binding]; other site 941193005817 Molecular Tunnel; other site 941193005818 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 941193005819 putative ADP-binding pocket [chemical binding]; other site 941193005820 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 941193005821 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941193005822 putative ADP-binding pocket [chemical binding]; other site 941193005823 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 941193005824 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 941193005825 putative NAD(P) binding site [chemical binding]; other site 941193005826 active site 941193005827 putative substrate binding site [chemical binding]; other site 941193005828 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 941193005829 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 941193005830 putative catalytic motif [active] 941193005831 putative substrate binding site [chemical binding]; other site 941193005832 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 941193005833 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 941193005834 NAD(P) binding site [chemical binding]; other site 941193005835 homodimer interface [polypeptide binding]; other site 941193005836 substrate binding site [chemical binding]; other site 941193005837 active site 941193005838 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 941193005839 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 941193005840 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941193005841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193005842 homodimer interface [polypeptide binding]; other site 941193005843 catalytic residue [active] 941193005844 excinuclease ABC subunit B; Provisional; Region: PRK05298 941193005845 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941193005846 ATP binding site [chemical binding]; other site 941193005847 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941193005848 nucleotide binding region [chemical binding]; other site 941193005849 ATP-binding site [chemical binding]; other site 941193005850 Ultra-violet resistance protein B; Region: UvrB; pfam12344 941193005851 UvrB/uvrC motif; Region: UVR; pfam02151 941193005852 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 941193005853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193005854 putative substrate translocation pore; other site 941193005855 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 941193005856 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193005857 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193005858 LysR family transcriptional regulator; Provisional; Region: PRK14997 941193005859 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193005860 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941193005861 putative effector binding pocket; other site 941193005862 dimerization interface [polypeptide binding]; other site 941193005863 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 941193005864 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 941193005865 HIGH motif; other site 941193005866 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 941193005867 active site 941193005868 KMSKS motif; other site 941193005869 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193005870 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193005871 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 941193005872 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 941193005873 Entner-Doudoroff aldolase; Region: eda; TIGR01182 941193005874 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 941193005875 active site 941193005876 intersubunit interface [polypeptide binding]; other site 941193005877 catalytic residue [active] 941193005878 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 941193005879 active site 941193005880 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 941193005881 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 941193005882 FMN binding site [chemical binding]; other site 941193005883 active site 941193005884 catalytic residues [active] 941193005885 substrate binding site [chemical binding]; other site 941193005886 short chain dehydrogenase; Provisional; Region: PRK06123 941193005887 classical (c) SDRs; Region: SDR_c; cd05233 941193005888 NAD(P) binding site [chemical binding]; other site 941193005889 active site 941193005890 BLMT, a bleomycin resistance protein encoded on the transposon Tn5, and similar proteins; Region: BLMT_like; cd08350 941193005891 dimer interface [polypeptide binding]; other site 941193005892 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941193005893 ligand binding site [chemical binding]; other site 941193005894 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941193005895 Coenzyme A binding pocket [chemical binding]; other site 941193005896 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 941193005897 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 941193005898 putative dimer interface [polypeptide binding]; other site 941193005899 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 941193005900 active site 941193005901 catalytic triad [active] 941193005902 oxyanion hole [active] 941193005903 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193005904 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193005905 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_10; cd08480 941193005906 putative effector binding pocket; other site 941193005907 putative dimerization interface [polypeptide binding]; other site 941193005908 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 941193005909 homotrimer interaction site [polypeptide binding]; other site 941193005910 putative active site [active] 941193005911 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193005912 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193005913 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941193005914 dimerization interface [polypeptide binding]; other site 941193005915 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 941193005916 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 941193005917 substrate binding site [chemical binding]; other site 941193005918 ligand binding site [chemical binding]; other site 941193005919 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 941193005920 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 941193005921 substrate binding site [chemical binding]; other site 941193005922 Methyltransferase domain; Region: Methyltransf_31; pfam13847 941193005923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193005924 S-adenosylmethionine binding site [chemical binding]; other site 941193005925 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 941193005926 tartrate dehydrogenase; Region: TTC; TIGR02089 941193005927 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 941193005928 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 941193005929 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671 941193005930 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 941193005931 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 941193005932 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941193005933 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 941193005934 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 941193005935 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 941193005936 dimerization interface 3.5A [polypeptide binding]; other site 941193005937 active site 941193005938 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 941193005939 active site 941193005940 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 941193005941 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 941193005942 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 941193005943 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941193005944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 941193005945 Sporulation related domain; Region: SPOR; pfam05036 941193005946 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 941193005947 Colicin V production protein; Region: Colicin_V; pfam02674 941193005948 amidophosphoribosyltransferase; Provisional; Region: PRK09246 941193005949 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 941193005950 active site 941193005951 tetramer interface [polypeptide binding]; other site 941193005952 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941193005953 active site 941193005954 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 941193005955 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 941193005956 homodimer interface [polypeptide binding]; other site 941193005957 substrate-cofactor binding pocket; other site 941193005958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193005959 catalytic residue [active] 941193005960 oxidoreductase; Validated; Region: PRK05717 941193005961 Clostridium thermocellum A3DFK9-like, a putative carbohydrate or polyalcohol metabolizing SDR, classical (c) SDRs; Region: A3DFK9-like_SDR_c; cd09761 941193005962 NAD binding site [chemical binding]; other site 941193005963 active site 941193005964 homodimer interface [polypeptide binding]; other site 941193005965 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 941193005966 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 941193005967 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 941193005968 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 941193005969 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 941193005970 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 941193005971 type II secretion system protein E; Region: type_II_gspE; TIGR02533 941193005972 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 941193005973 Walker A motif; other site 941193005974 ATP binding site [chemical binding]; other site 941193005975 Walker B motif; other site 941193005976 type II secretion system protein F; Region: GspF; TIGR02120 941193005977 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 941193005978 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 941193005979 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 941193005980 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 941193005981 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 941193005982 type II secretion system protein I; Region: gspI; TIGR01707 941193005983 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 941193005984 type II secretion system protein J; Region: gspJ; TIGR01711 941193005985 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 941193005986 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 941193005987 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 941193005988 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 941193005989 GspL periplasmic domain; Region: GspL_C; pfam12693 941193005990 Type II secretory pathway, component PulM [Intracellular trafficking and secretion]; Region: PulM; COG3149 941193005991 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 941193005992 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941193005993 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193005994 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 941193005995 Predicted amidohydrolase [General function prediction only]; Region: COG0388 941193005996 active site 941193005997 catalytic triad [active] 941193005998 dimer interface [polypeptide binding]; other site 941193005999 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 941193006000 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 941193006001 active site 941193006002 FMN binding site [chemical binding]; other site 941193006003 2,4-decadienoyl-CoA binding site; other site 941193006004 catalytic residue [active] 941193006005 4Fe-4S cluster binding site [ion binding]; other site 941193006006 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 941193006007 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 941193006008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3782 941193006009 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 941193006010 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 941193006011 Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413 941193006012 active site 941193006013 metal binding site [ion binding]; metal-binding site 941193006014 Rhomboid family; Region: Rhomboid; pfam01694 941193006015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 941193006016 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 941193006017 aminopeptidase N; Provisional; Region: pepN; PRK14015 941193006018 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 941193006019 active site 941193006020 Zn binding site [ion binding]; other site 941193006021 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 941193006022 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 941193006023 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 941193006024 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 941193006025 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941193006026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193006027 dimer interface [polypeptide binding]; other site 941193006028 phosphorylation site [posttranslational modification] 941193006029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193006030 ATP binding site [chemical binding]; other site 941193006031 Mg2+ binding site [ion binding]; other site 941193006032 G-X-G motif; other site 941193006033 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941193006034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193006035 active site 941193006036 phosphorylation site [posttranslational modification] 941193006037 intermolecular recognition site; other site 941193006038 dimerization interface [polypeptide binding]; other site 941193006039 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193006040 DNA binding site [nucleotide binding] 941193006041 chlorophyllase; Region: PLN00021 941193006042 Oxygen tolerance; Region: BatD; pfam13584 941193006043 von Willebrand factor type A domain; Region: VWA_2; pfam13519 941193006044 metal ion-dependent adhesion site (MIDAS); other site 941193006045 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941193006046 TPR repeat; Region: TPR_11; pfam13414 941193006047 binding surface 941193006048 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 941193006049 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 941193006050 metal ion-dependent adhesion site (MIDAS); other site 941193006051 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 941193006052 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 941193006053 Protein of unknown function DUF58; Region: DUF58; pfam01882 941193006054 MoxR-like ATPases [General function prediction only]; Region: COG0714 941193006055 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 941193006056 Walker A motif; other site 941193006057 ATP binding site [chemical binding]; other site 941193006058 Walker B motif; other site 941193006059 arginine finger; other site 941193006060 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 941193006061 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 941193006062 Uncharacterized conserved protein [Function unknown]; Region: COG3868 941193006063 C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922 941193006064 putative active site [active] 941193006065 Tetratricopeptide repeat; Region: TPR_15; pfam13429 941193006066 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 941193006067 GAF domain; Region: GAF_3; pfam13492 941193006068 HEAT repeats; Region: HEAT_2; pfam13646 941193006069 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 941193006070 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941193006071 Predicted membrane protein [Function unknown]; Region: COG4267 941193006072 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 941193006073 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941193006074 non-specific DNA binding site [nucleotide binding]; other site 941193006075 salt bridge; other site 941193006076 sequence-specific DNA binding site [nucleotide binding]; other site 941193006077 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941193006078 non-specific DNA binding site [nucleotide binding]; other site 941193006079 salt bridge; other site 941193006080 sequence-specific DNA binding site [nucleotide binding]; other site 941193006081 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 941193006082 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 941193006083 putative active site [active] 941193006084 Zn binding site [ion binding]; other site 941193006085 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 941193006086 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 941193006087 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 941193006088 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 941193006089 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 941193006090 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 941193006091 quinone interaction residues [chemical binding]; other site 941193006092 active site 941193006093 catalytic residues [active] 941193006094 FMN binding site [chemical binding]; other site 941193006095 substrate binding site [chemical binding]; other site 941193006096 Ribosome modulation factor [Translation, ribosomal structure and biogenesis]; Region: Rmf; COG3130 941193006097 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 941193006098 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 941193006099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 941193006100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193006101 S-adenosylmethionine binding site [chemical binding]; other site 941193006102 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 941193006103 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 941193006104 hypothetical protein; Provisional; Region: PRK11702 941193006105 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941193006106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193006107 active site 941193006108 phosphorylation site [posttranslational modification] 941193006109 intermolecular recognition site; other site 941193006110 dimerization interface [polypeptide binding]; other site 941193006111 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193006112 DNA binding residues [nucleotide binding] 941193006113 dimerization interface [polypeptide binding]; other site 941193006114 PAS domain; Region: PAS_9; pfam13426 941193006115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193006116 dimer interface [polypeptide binding]; other site 941193006117 phosphorylation site [posttranslational modification] 941193006118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193006119 ATP binding site [chemical binding]; other site 941193006120 Mg2+ binding site [ion binding]; other site 941193006121 G-X-G motif; other site 941193006122 Response regulator receiver domain; Region: Response_reg; pfam00072 941193006123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193006124 active site 941193006125 phosphorylation site [posttranslational modification] 941193006126 intermolecular recognition site; other site 941193006127 dimerization interface [polypeptide binding]; other site 941193006128 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 941193006129 putative binding surface; other site 941193006130 active site 941193006131 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 941193006132 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941193006133 Zn2+ binding site [ion binding]; other site 941193006134 Mg2+ binding site [ion binding]; other site 941193006135 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 941193006136 Predicted membrane protein [Function unknown]; Region: COG5393 941193006137 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 941193006138 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 941193006139 outer membrane porin, OprD family; Region: OprD; pfam03573 941193006140 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941193006141 Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576 941193006142 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 941193006143 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 941193006144 putative C-terminal domain interface [polypeptide binding]; other site 941193006145 putative GSH binding site (G-site) [chemical binding]; other site 941193006146 putative dimer interface [polypeptide binding]; other site 941193006147 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 941193006148 putative N-terminal domain interface [polypeptide binding]; other site 941193006149 putative dimer interface [polypeptide binding]; other site 941193006150 putative substrate binding pocket (H-site) [chemical binding]; other site 941193006151 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193006152 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193006153 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 941193006154 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 941193006155 Cytochrome c; Region: Cytochrom_C; pfam00034 941193006156 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 941193006157 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 941193006158 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 941193006159 GTP binding site; other site 941193006160 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 941193006161 MPT binding site; other site 941193006162 trimer interface [polypeptide binding]; other site 941193006163 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 941193006164 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 941193006165 dimer interface [polypeptide binding]; other site 941193006166 putative functional site; other site 941193006167 putative MPT binding site; other site 941193006168 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 941193006169 Helix-turn-helix domain; Region: HTH_18; pfam12833 941193006170 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193006171 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 941193006172 FAD binding domain; Region: FAD_binding_4; pfam01565 941193006173 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 941193006174 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 941193006175 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 941193006176 putative N- and C-terminal domain interface [polypeptide binding]; other site 941193006177 putative active site [active] 941193006178 MgATP binding site [chemical binding]; other site 941193006179 catalytic site [active] 941193006180 metal binding site [ion binding]; metal-binding site 941193006181 putative carbohydrate binding site [chemical binding]; other site 941193006182 lipid kinase; Reviewed; Region: PRK13054 941193006183 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 941193006184 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 941193006185 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 941193006186 MOSC domain; Region: MOSC; pfam03473 941193006187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 941193006188 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 941193006189 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 941193006190 N-acetyl-D-glucosamine binding site [chemical binding]; other site 941193006191 catalytic residue [active] 941193006192 ABC transporter ATPase component; Reviewed; Region: PRK11147 941193006193 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941193006194 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941193006195 ABC transporter; Region: ABC_tran_2; pfam12848 941193006196 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941193006197 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 941193006198 Ligand Binding Site [chemical binding]; other site 941193006199 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 941193006200 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 941193006201 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941193006202 substrate binding site [chemical binding]; other site 941193006203 oxyanion hole (OAH) forming residues; other site 941193006204 trimer interface [polypeptide binding]; other site 941193006205 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 941193006206 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 941193006207 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 941193006208 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 941193006209 dimer interface [polypeptide binding]; other site 941193006210 active site 941193006211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4728 941193006212 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 941193006213 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 941193006214 active site 941193006215 interdomain interaction site; other site 941193006216 putative metal-binding site [ion binding]; other site 941193006217 nucleotide binding site [chemical binding]; other site 941193006218 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 941193006219 domain I; other site 941193006220 DNA binding groove [nucleotide binding] 941193006221 phosphate binding site [ion binding]; other site 941193006222 domain II; other site 941193006223 domain III; other site 941193006224 nucleotide binding site [chemical binding]; other site 941193006225 catalytic site [active] 941193006226 domain IV; other site 941193006227 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 941193006228 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 941193006229 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 941193006230 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 941193006231 SOS-response cell division inhibitor, blocks FtsZ ring formation [Cell division and chromosome partitioning]; Region: SulA; COG5404 941193006232 LexA repressor; Validated; Region: PRK00215 941193006233 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 941193006234 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 941193006235 Catalytic site [active] 941193006236 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193006237 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193006238 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 941193006239 beta-hexosaminidase; Provisional; Region: PRK05337 941193006240 5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136 941193006241 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 941193006242 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 941193006243 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 941193006244 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941193006245 ATP binding site [chemical binding]; other site 941193006246 putative Mg++ binding site [ion binding]; other site 941193006247 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941193006248 nucleotide binding region [chemical binding]; other site 941193006249 ATP-binding site [chemical binding]; other site 941193006250 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 941193006251 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 941193006252 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 941193006253 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 941193006254 aromatic amino acid transporter; Provisional; Region: PRK10238 941193006255 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 941193006256 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 941193006257 E3 interaction surface; other site 941193006258 lipoyl attachment site [posttranslational modification]; other site 941193006259 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 941193006260 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 941193006261 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 941193006262 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 941193006263 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 941193006264 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 941193006265 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 941193006266 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941193006267 catalytic loop [active] 941193006268 iron binding site [ion binding]; other site 941193006269 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 941193006270 FAD binding pocket [chemical binding]; other site 941193006271 FAD binding motif [chemical binding]; other site 941193006272 phosphate binding motif [ion binding]; other site 941193006273 beta-alpha-beta structure motif; other site 941193006274 NAD binding pocket [chemical binding]; other site 941193006275 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 941193006276 ApbE family; Region: ApbE; pfam02424 941193006277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 941193006278 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 941193006279 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941193006280 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941193006281 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 941193006282 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 941193006283 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 941193006284 active site 941193006285 catalytic site [active] 941193006286 metal binding site [ion binding]; metal-binding site 941193006287 PilZ domain; Region: PilZ; pfam07238 941193006288 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 941193006289 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 941193006290 FtsX-like permease family; Region: FtsX; pfam02687 941193006291 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 941193006292 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 941193006293 Walker A/P-loop; other site 941193006294 ATP binding site [chemical binding]; other site 941193006295 Q-loop/lid; other site 941193006296 ABC transporter signature motif; other site 941193006297 Walker B; other site 941193006298 D-loop; other site 941193006299 H-loop/switch region; other site 941193006300 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 941193006301 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 941193006302 FtsX-like permease family; Region: FtsX; pfam02687 941193006303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 941193006304 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 941193006305 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 941193006306 Competence protein; Region: Competence; pfam03772 941193006307 Competence protein; Region: Competence; cl00471 941193006308 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 941193006309 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 941193006310 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 941193006311 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 941193006312 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 941193006313 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 941193006314 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 941193006315 Uncharacterized conserved protein [Function unknown]; Region: COG2835 941193006316 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 941193006317 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 941193006318 Ligand binding site; other site 941193006319 oligomer interface; other site 941193006320 Low molecular weight phosphatase family; Region: LMWPc; cd00115 941193006321 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 941193006322 active site 941193006323 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 941193006324 FAD binding domain; Region: FAD_binding_4; pfam01565 941193006325 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 941193006326 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 941193006327 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 941193006328 homodimer interface [polypeptide binding]; other site 941193006329 oligonucleotide binding site [chemical binding]; other site 941193006330 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 941193006331 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941193006332 RNA binding surface [nucleotide binding]; other site 941193006333 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 941193006334 active site 941193006335 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 941193006336 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941193006337 motif II; other site 941193006338 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 941193006339 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 941193006340 tandem repeat interface [polypeptide binding]; other site 941193006341 oligomer interface [polypeptide binding]; other site 941193006342 active site residues [active] 941193006343 Maf-like protein; Region: Maf; pfam02545 941193006344 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 941193006345 active site 941193006346 dimer interface [polypeptide binding]; other site 941193006347 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 941193006348 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 941193006349 putative phosphate acyltransferase; Provisional; Region: PRK05331 941193006350 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 941193006351 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 941193006352 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 941193006353 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 941193006354 NAD(P) binding site [chemical binding]; other site 941193006355 homotetramer interface [polypeptide binding]; other site 941193006356 homodimer interface [polypeptide binding]; other site 941193006357 active site 941193006358 acyl carrier protein; Provisional; Region: acpP; PRK00982 941193006359 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 941193006360 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 941193006361 dimer interface [polypeptide binding]; other site 941193006362 active site 941193006363 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 941193006364 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 941193006365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193006366 catalytic residue [active] 941193006367 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 941193006368 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 941193006369 dimerization interface [polypeptide binding]; other site 941193006370 thymidylate kinase; Validated; Region: tmk; PRK00698 941193006371 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 941193006372 TMP-binding site; other site 941193006373 ATP-binding site [chemical binding]; other site 941193006374 DNA polymerase III subunit delta'; Validated; Region: PRK05707 941193006375 DNA polymerase III subunit delta'; Validated; Region: PRK08485 941193006376 Tfp pilus assembly protein PilZ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilZ; COG3215 941193006377 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 941193006378 active site 941193006379 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 941193006380 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941193006381 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941193006382 catalytic residue [active] 941193006383 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193006384 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193006385 WHG domain; Region: WHG; pfam13305 941193006386 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941193006387 Radical SAM superfamily; Region: Radical_SAM; pfam04055 941193006388 FeS/SAM binding site; other site 941193006389 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 941193006390 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 941193006391 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 941193006392 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941193006393 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 941193006394 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 941193006395 Ligand binding site [chemical binding]; other site 941193006396 Electron transfer flavoprotein domain; Region: ETF; pfam01012 941193006397 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 941193006398 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 941193006399 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 941193006400 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 941193006401 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 941193006402 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 941193006403 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 941193006404 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 941193006405 nucleophilic elbow; other site 941193006406 catalytic triad; other site 941193006407 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 941193006408 active site 941193006409 SAM binding site [chemical binding]; other site 941193006410 homodimer interface [polypeptide binding]; other site 941193006411 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 941193006412 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 941193006413 Predicted integral membrane protein [Function unknown]; Region: COG5446 941193006414 Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489 941193006415 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 941193006416 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 941193006417 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 941193006418 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 941193006419 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 941193006420 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 941193006421 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 941193006422 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 941193006423 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 941193006424 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193006425 Walker A motif; other site 941193006426 ATP binding site [chemical binding]; other site 941193006427 Walker B motif; other site 941193006428 arginine finger; other site 941193006429 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 941193006430 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 941193006431 metal ion-dependent adhesion site (MIDAS); other site 941193006432 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 941193006433 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 941193006434 dimer interface [polypeptide binding]; other site 941193006435 active site 941193006436 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 941193006437 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 941193006438 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 941193006439 PA/protease or protease-like domain interface [polypeptide binding]; other site 941193006440 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 941193006441 active site 941193006442 metal binding site [ion binding]; metal-binding site 941193006443 xanthine permease; Region: pbuX; TIGR03173 941193006444 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 941193006445 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 941193006446 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 941193006447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193006448 putative substrate translocation pore; other site 941193006449 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 941193006450 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 941193006451 FMN binding site [chemical binding]; other site 941193006452 active site 941193006453 substrate binding site [chemical binding]; other site 941193006454 catalytic residue [active] 941193006455 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193006456 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193006457 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193006458 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193006459 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193006460 dimerization interface [polypeptide binding]; other site 941193006461 LysE type translocator; Region: LysE; cl00565 941193006462 Serine hydrolase; Region: Ser_hydrolase; cl17834 941193006463 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 941193006464 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 941193006465 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 941193006466 Walker A/P-loop; other site 941193006467 ATP binding site [chemical binding]; other site 941193006468 Q-loop/lid; other site 941193006469 ABC transporter signature motif; other site 941193006470 Walker B; other site 941193006471 D-loop; other site 941193006472 H-loop/switch region; other site 941193006473 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 941193006474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193006475 dimer interface [polypeptide binding]; other site 941193006476 conserved gate region; other site 941193006477 putative PBP binding loops; other site 941193006478 ABC-ATPase subunit interface; other site 941193006479 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 941193006480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193006481 dimer interface [polypeptide binding]; other site 941193006482 conserved gate region; other site 941193006483 putative PBP binding loops; other site 941193006484 ABC-ATPase subunit interface; other site 941193006485 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 941193006486 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193006487 substrate binding pocket [chemical binding]; other site 941193006488 membrane-bound complex binding site; other site 941193006489 hinge residues; other site 941193006490 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 941193006491 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 941193006492 metal binding site [ion binding]; metal-binding site 941193006493 putative dimer interface [polypeptide binding]; other site 941193006494 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 941193006495 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193006496 LysR substrate binding domain; Region: LysR_substrate; pfam03466 941193006497 dimerization interface [polypeptide binding]; other site 941193006498 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193006499 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 941193006500 dimerization interface [polypeptide binding]; other site 941193006501 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193006502 dimer interface [polypeptide binding]; other site 941193006503 putative CheW interface [polypeptide binding]; other site 941193006504 short chain dehydrogenase; Provisional; Region: PRK12744 941193006505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193006506 NAD(P) binding site [chemical binding]; other site 941193006507 active site 941193006508 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 941193006509 Helix-turn-helix domain; Region: HTH_18; pfam12833 941193006510 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193006511 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 941193006512 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 941193006513 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 941193006514 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941193006515 ABC-ATPase subunit interface; other site 941193006516 dimer interface [polypeptide binding]; other site 941193006517 putative PBP binding regions; other site 941193006518 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 941193006519 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 941193006520 putative ligand binding residues [chemical binding]; other site 941193006521 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 941193006522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193006523 Walker A/P-loop; other site 941193006524 ATP binding site [chemical binding]; other site 941193006525 Q-loop/lid; other site 941193006526 ABC transporter signature motif; other site 941193006527 Walker B; other site 941193006528 H-loop/switch region; other site 941193006529 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 941193006530 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193006531 N-terminal plug; other site 941193006532 ligand-binding site [chemical binding]; other site 941193006533 Predicted membrane protein [Function unknown]; Region: COG1971 941193006534 Domain of unknown function DUF; Region: DUF204; pfam02659 941193006535 Domain of unknown function DUF; Region: DUF204; pfam02659 941193006536 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 941193006537 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 941193006538 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 941193006539 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 941193006540 active site 941193006541 putative homodimer interface [polypeptide binding]; other site 941193006542 SAM binding site [chemical binding]; other site 941193006543 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 941193006544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193006545 S-adenosylmethionine binding site [chemical binding]; other site 941193006546 precorrin-3B synthase; Region: CobG; TIGR02435 941193006547 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 941193006548 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 941193006549 Precorrin-8X methylmutase; Region: CbiC; pfam02570 941193006550 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 941193006551 homodimer interface [polypeptide binding]; other site 941193006552 active site 941193006553 SAM binding site [chemical binding]; other site 941193006554 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 941193006555 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 941193006556 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 941193006557 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 941193006558 active site 941193006559 SAM binding site [chemical binding]; other site 941193006560 homodimer interface [polypeptide binding]; other site 941193006561 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193006562 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941193006563 substrate binding pocket [chemical binding]; other site 941193006564 membrane-bound complex binding site; other site 941193006565 hinge residues; other site 941193006566 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 941193006567 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 941193006568 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 941193006569 ligand binding site [chemical binding]; other site 941193006570 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941193006571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193006572 active site 941193006573 phosphorylation site [posttranslational modification] 941193006574 intermolecular recognition site; other site 941193006575 dimerization interface [polypeptide binding]; other site 941193006576 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193006577 DNA binding residues [nucleotide binding] 941193006578 dimerization interface [polypeptide binding]; other site 941193006579 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 941193006580 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193006581 DNA-binding site [nucleotide binding]; DNA binding site 941193006582 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941193006583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193006584 homodimer interface [polypeptide binding]; other site 941193006585 catalytic residue [active] 941193006586 RNA polymerase sigma factor; Provisional; Region: PRK12513 941193006587 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941193006588 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941193006589 DNA binding residues [nucleotide binding] 941193006590 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 941193006591 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 941193006592 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 941193006593 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 941193006594 acyl-activating enzyme (AAE) consensus motif; other site 941193006595 acyl-activating enzyme (AAE) consensus motif; other site 941193006596 putative AMP binding site [chemical binding]; other site 941193006597 putative active site [active] 941193006598 putative CoA binding site [chemical binding]; other site 941193006599 short chain dehydrogenase; Provisional; Region: PRK08278 941193006600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193006601 NAD(P) binding site [chemical binding]; other site 941193006602 active site 941193006603 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 941193006604 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 941193006605 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 941193006606 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 941193006607 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 941193006608 carboxyltransferase (CT) interaction site; other site 941193006609 biotinylation site [posttranslational modification]; other site 941193006610 enoyl-CoA hydratase; Provisional; Region: PRK05995 941193006611 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941193006612 substrate binding site [chemical binding]; other site 941193006613 oxyanion hole (OAH) forming residues; other site 941193006614 trimer interface [polypeptide binding]; other site 941193006615 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941193006616 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193006617 active site 941193006618 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 941193006619 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 941193006620 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 941193006621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193006622 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 941193006623 NAD(P) binding site [chemical binding]; other site 941193006624 active site 941193006625 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 941193006626 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193006627 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193006628 CAAX protease self-immunity; Region: Abi; pfam02517 941193006629 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 941193006630 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 941193006631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193006632 ATP binding site [chemical binding]; other site 941193006633 Mg2+ binding site [ion binding]; other site 941193006634 G-X-G motif; other site 941193006635 Response regulator receiver domain; Region: Response_reg; pfam00072 941193006636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193006637 active site 941193006638 phosphorylation site [posttranslational modification] 941193006639 intermolecular recognition site; other site 941193006640 dimerization interface [polypeptide binding]; other site 941193006641 Predicted membrane protein [Function unknown]; Region: COG4125 941193006642 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 941193006643 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 941193006644 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193006645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193006646 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941193006647 dimerization interface [polypeptide binding]; other site 941193006648 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 941193006649 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193006650 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193006651 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 941193006652 putative effector binding pocket; other site 941193006653 putative dimerization interface [polypeptide binding]; other site 941193006654 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 941193006655 active site 941193006656 dimer interface [polypeptide binding]; other site 941193006657 MoxR-like ATPases [General function prediction only]; Region: COG0714 941193006658 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193006659 Walker A motif; other site 941193006660 ATP binding site [chemical binding]; other site 941193006661 Walker B motif; other site 941193006662 arginine finger; other site 941193006663 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 941193006664 Protein of unknown function DUF58; Region: DUF58; pfam01882 941193006665 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 941193006666 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 941193006667 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 941193006668 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 941193006669 Uncharacterized conserved protein [Function unknown]; Region: COG5607 941193006670 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 941193006671 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 941193006672 active site 941193006673 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 941193006674 active site 2 [active] 941193006675 active site 1 [active] 941193006676 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193006677 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193006678 metal binding site [ion binding]; metal-binding site 941193006679 active site 941193006680 I-site; other site 941193006681 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 941193006682 Terminase small subunit; Region: Terminase_2; cl01513 941193006683 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193006684 dimerization interface [polypeptide binding]; other site 941193006685 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941193006686 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193006687 dimer interface [polypeptide binding]; other site 941193006688 putative CheW interface [polypeptide binding]; other site 941193006689 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 941193006690 active site 941193006691 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623 941193006692 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193006693 substrate binding pocket [chemical binding]; other site 941193006694 membrane-bound complex binding site; other site 941193006695 hinge residues; other site 941193006696 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 941193006697 N-acetyl-D-glucosamine binding site [chemical binding]; other site 941193006698 catalytic residue [active] 941193006699 Predicted membrane protein [Function unknown]; Region: COG2259 941193006700 lipase chaperone; Provisional; Region: PRK01294 941193006701 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 941193006702 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 941193006703 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 941193006704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 941193006705 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 941193006706 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 941193006707 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 941193006708 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 941193006709 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 941193006710 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 941193006711 Walker A/P-loop; other site 941193006712 ATP binding site [chemical binding]; other site 941193006713 Q-loop/lid; other site 941193006714 ABC transporter signature motif; other site 941193006715 Walker B; other site 941193006716 D-loop; other site 941193006717 H-loop/switch region; other site 941193006718 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 941193006719 active site 941193006720 catalytic triad [active] 941193006721 oxyanion hole [active] 941193006722 switch loop; other site 941193006723 L,D-transpeptidase; Provisional; Region: PRK10260 941193006724 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 941193006725 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 941193006726 Protein of unknown function (DUF3359); Region: DUF3359; pfam11839 941193006727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 941193006728 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 941193006729 elongation factor P; Validated; Region: PRK00529 941193006730 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 941193006731 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 941193006732 RNA binding site [nucleotide binding]; other site 941193006733 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 941193006734 RNA binding site [nucleotide binding]; other site 941193006735 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 941193006736 Transcriptional regulators [Transcription]; Region: MarR; COG1846 941193006737 MarR family; Region: MarR; pfam01047 941193006738 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193006739 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193006740 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941193006741 putative effector binding pocket; other site 941193006742 dimerization interface [polypeptide binding]; other site 941193006743 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 941193006744 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193006745 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193006746 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193006747 dimerization interface [polypeptide binding]; other site 941193006748 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 941193006749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 941193006750 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 941193006751 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 941193006752 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 941193006753 enoyl-CoA hydratase; Provisional; Region: PRK06563 941193006754 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941193006755 substrate binding site [chemical binding]; other site 941193006756 oxyanion hole (OAH) forming residues; other site 941193006757 trimer interface [polypeptide binding]; other site 941193006758 helicase 45; Provisional; Region: PTZ00424 941193006759 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 941193006760 ATP binding site [chemical binding]; other site 941193006761 Mg++ binding site [ion binding]; other site 941193006762 motif III; other site 941193006763 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941193006764 nucleotide binding region [chemical binding]; other site 941193006765 ATP-binding site [chemical binding]; other site 941193006766 DbpA RNA binding domain; Region: DbpA; pfam03880 941193006767 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 941193006768 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 941193006769 putative active site [active] 941193006770 metal binding site [ion binding]; metal-binding site 941193006771 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193006772 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193006773 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941193006774 putative effector binding pocket; other site 941193006775 dimerization interface [polypeptide binding]; other site 941193006776 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 941193006777 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 941193006778 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193006779 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193006780 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 941193006781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193006782 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193006783 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193006784 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 941193006785 putative substrate binding pocket [chemical binding]; other site 941193006786 putative dimerization interface [polypeptide binding]; other site 941193006787 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 941193006788 Ligand Binding Site [chemical binding]; other site 941193006789 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 941193006790 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 941193006791 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 941193006792 putative active site [active] 941193006793 Zn binding site [ion binding]; other site 941193006794 heat shock protein HtpX; Provisional; Region: PRK05457 941193006795 aminotransferase AlaT; Validated; Region: PRK09265 941193006796 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941193006797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193006798 homodimer interface [polypeptide binding]; other site 941193006799 catalytic residue [active] 941193006800 methionine sulfoxide reductase B; Provisional; Region: PRK00222 941193006801 SelR domain; Region: SelR; pfam01641 941193006802 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 941193006803 catalytic residues [active] 941193006804 dimer interface [polypeptide binding]; other site 941193006805 MarR family; Region: MarR_2; cl17246 941193006806 Transcriptional regulators [Transcription]; Region: MarR; COG1846 941193006807 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 941193006808 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193006809 ATP binding site [chemical binding]; other site 941193006810 Mg2+ binding site [ion binding]; other site 941193006811 G-X-G motif; other site 941193006812 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 941193006813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193006814 active site 941193006815 phosphorylation site [posttranslational modification] 941193006816 intermolecular recognition site; other site 941193006817 dimerization interface [polypeptide binding]; other site 941193006818 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 941193006819 Protein of unknown function (DUF815); Region: DUF815; pfam05673 941193006820 Walker A motif; other site 941193006821 ATP binding site [chemical binding]; other site 941193006822 Walker B motif; other site 941193006823 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 941193006824 GAF domain; Region: GAF_2; pfam13185 941193006825 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 941193006826 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 941193006827 C-terminal domain interface [polypeptide binding]; other site 941193006828 GSH binding site (G-site) [chemical binding]; other site 941193006829 dimer interface [polypeptide binding]; other site 941193006830 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 941193006831 N-terminal domain interface [polypeptide binding]; other site 941193006832 dimer interface [polypeptide binding]; other site 941193006833 substrate binding pocket (H-site) [chemical binding]; other site 941193006834 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 941193006835 phage resistance protein; Provisional; Region: PRK10551 941193006836 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941193006837 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 941193006838 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 941193006839 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 941193006840 active site 941193006841 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 941193006842 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 941193006843 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 941193006844 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 941193006845 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 941193006846 putative C-terminal domain interface [polypeptide binding]; other site 941193006847 putative GSH binding site (G-site) [chemical binding]; other site 941193006848 putative dimer interface [polypeptide binding]; other site 941193006849 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 941193006850 putative N-terminal domain interface [polypeptide binding]; other site 941193006851 putative dimer interface [polypeptide binding]; other site 941193006852 putative substrate binding pocket (H-site) [chemical binding]; other site 941193006853 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941193006854 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193006855 Walker A/P-loop; other site 941193006856 ATP binding site [chemical binding]; other site 941193006857 Q-loop/lid; other site 941193006858 ABC transporter signature motif; other site 941193006859 Walker B; other site 941193006860 D-loop; other site 941193006861 H-loop/switch region; other site 941193006862 inner membrane transport permease; Provisional; Region: PRK15066 941193006863 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 941193006864 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 941193006865 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193006866 dimerization interface [polypeptide binding]; other site 941193006867 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193006868 dimer interface [polypeptide binding]; other site 941193006869 phosphorylation site [posttranslational modification] 941193006870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193006871 ATP binding site [chemical binding]; other site 941193006872 Mg2+ binding site [ion binding]; other site 941193006873 G-X-G motif; other site 941193006874 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 941193006875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193006876 active site 941193006877 phosphorylation site [posttranslational modification] 941193006878 intermolecular recognition site; other site 941193006879 dimerization interface [polypeptide binding]; other site 941193006880 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193006881 DNA binding site [nucleotide binding] 941193006882 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 941193006883 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 941193006884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 941193006885 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 941193006886 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 941193006887 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 941193006888 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941193006889 Zn2+ binding site [ion binding]; other site 941193006890 Mg2+ binding site [ion binding]; other site 941193006891 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 941193006892 transcriptional regulator protein; Region: phnR; TIGR03337 941193006893 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193006894 DNA-binding site [nucleotide binding]; DNA binding site 941193006895 UTRA domain; Region: UTRA; pfam07702 941193006896 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 941193006897 active site 941193006898 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 941193006899 PilZ domain; Region: PilZ; pfam07238 941193006900 Response regulator receiver domain; Region: Response_reg; pfam00072 941193006901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193006902 active site 941193006903 phosphorylation site [posttranslational modification] 941193006904 intermolecular recognition site; other site 941193006905 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 941193006906 dimerization interface [polypeptide binding]; other site 941193006907 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 941193006908 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 941193006909 anti sigma factor interaction site; other site 941193006910 regulatory phosphorylation site [posttranslational modification]; other site 941193006911 transaldolase-like protein; Provisional; Region: PTZ00411 941193006912 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 941193006913 active site 941193006914 dimer interface [polypeptide binding]; other site 941193006915 catalytic residue [active] 941193006916 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 941193006917 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 941193006918 FMN binding site [chemical binding]; other site 941193006919 active site 941193006920 catalytic residues [active] 941193006921 substrate binding site [chemical binding]; other site 941193006922 drug efflux system protein MdtG; Provisional; Region: PRK09874 941193006923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193006924 putative substrate translocation pore; other site 941193006925 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 941193006926 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941193006927 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193006928 dimer interface [polypeptide binding]; other site 941193006929 putative CheW interface [polypeptide binding]; other site 941193006930 glutamate carboxypeptidase; Reviewed; Region: PRK06133 941193006931 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 941193006932 metal binding site [ion binding]; metal-binding site 941193006933 dimer interface [polypeptide binding]; other site 941193006934 GAF domain; Region: GAF_2; pfam13185 941193006935 Predicted transcriptional regulator [Transcription]; Region: COG3655 941193006936 salt bridge; other site 941193006937 non-specific DNA binding site [nucleotide binding]; other site 941193006938 sequence-specific DNA binding site [nucleotide binding]; other site 941193006939 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 941193006940 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_3; pfam13582 941193006941 active site 941193006942 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 941193006943 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 941193006944 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 941193006945 putative active site [active] 941193006946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 941193006947 binding surface 941193006948 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 941193006949 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 941193006950 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 941193006951 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 941193006952 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 941193006953 GAF domain; Region: GAF; pfam01590 941193006954 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193006955 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193006956 metal binding site [ion binding]; metal-binding site 941193006957 active site 941193006958 I-site; other site 941193006959 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 941193006960 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 941193006961 nudix motif; other site 941193006962 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 941193006963 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941193006964 substrate binding site [chemical binding]; other site 941193006965 oxyanion hole (OAH) forming residues; other site 941193006966 trimer interface [polypeptide binding]; other site 941193006967 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193006968 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193006969 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 941193006970 Serine hydrolase; Region: Ser_hydrolase; cl17834 941193006971 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 941193006972 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 941193006973 outer membrane porin, OprD family; Region: OprD; pfam03573 941193006974 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193006975 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193006976 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941193006977 dimerization interface [polypeptide binding]; other site 941193006978 Predicted membrane protein [Function unknown]; Region: COG4125 941193006979 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 941193006980 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 941193006981 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 941193006982 Serine protease inhibitor ecotin [General function prediction only]; Region: Eco; COG4574 941193006983 secondary substrate binding site; other site 941193006984 primary substrate binding site; other site 941193006985 inhibition loop; other site 941193006986 dimerization interface [polypeptide binding]; other site 941193006987 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 941193006988 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 941193006989 Predicted membrane protein [Function unknown]; Region: COG1238 941193006990 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 941193006991 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 941193006992 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 941193006993 DNA-specific endonuclease I; Provisional; Region: PRK15137 941193006994 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 941193006995 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 941193006996 active site 941193006997 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 941193006998 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 941193006999 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 941193007000 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 941193007001 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 941193007002 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 941193007003 active site 941193007004 dimer interface [polypeptide binding]; other site 941193007005 motif 1; other site 941193007006 motif 2; other site 941193007007 motif 3; other site 941193007008 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 941193007009 anticodon binding site; other site 941193007010 translation initiation factor IF-3; Region: infC; TIGR00168 941193007011 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 941193007012 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 941193007013 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 941193007014 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 941193007015 23S rRNA binding site [nucleotide binding]; other site 941193007016 L21 binding site [polypeptide binding]; other site 941193007017 L13 binding site [polypeptide binding]; other site 941193007018 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 941193007019 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 941193007020 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 941193007021 dimer interface [polypeptide binding]; other site 941193007022 motif 1; other site 941193007023 active site 941193007024 motif 2; other site 941193007025 motif 3; other site 941193007026 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 941193007027 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 941193007028 putative tRNA-binding site [nucleotide binding]; other site 941193007029 B3/4 domain; Region: B3_4; pfam03483 941193007030 tRNA synthetase B5 domain; Region: B5; smart00874 941193007031 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 941193007032 dimer interface [polypeptide binding]; other site 941193007033 motif 1; other site 941193007034 motif 3; other site 941193007035 motif 2; other site 941193007036 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 941193007037 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 941193007038 IHF dimer interface [polypeptide binding]; other site 941193007039 IHF - DNA interface [nucleotide binding]; other site 941193007040 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 941193007041 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 941193007042 DNA binding residues [nucleotide binding] 941193007043 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 941193007044 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 941193007045 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941193007046 ATP binding site [chemical binding]; other site 941193007047 putative Mg++ binding site [ion binding]; other site 941193007048 HsdM N-terminal domain; Region: HsdM_N; pfam12161 941193007049 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 941193007050 Methyltransferase domain; Region: Methyltransf_26; pfam13659 941193007051 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 941193007052 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 941193007053 AAA domain; Region: AAA_21; pfam13304 941193007054 AAA domain; Region: AAA_21; pfam13304 941193007055 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 941193007056 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 941193007057 Transposase; Region: HTH_Tnp_1; pfam01527 941193007058 HTH-like domain; Region: HTH_21; pfam13276 941193007059 Integrase core domain; Region: rve; pfam00665 941193007060 DDE domain; Region: DDE_Tnp_IS240; pfam13610 941193007061 Integrase core domain; Region: rve_3; pfam13683 941193007062 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 941193007063 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 941193007064 active site 941193007065 ATP binding site [chemical binding]; other site 941193007066 substrate binding site [chemical binding]; other site 941193007067 activation loop (A-loop); other site 941193007068 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 941193007069 AAA domain; Region: AAA_11; pfam13086 941193007070 Part of AAA domain; Region: AAA_19; pfam13245 941193007071 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 941193007072 AAA domain; Region: AAA_12; pfam13087 941193007073 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 941193007074 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 941193007075 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 941193007076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193007077 Walker A motif; other site 941193007078 ATP binding site [chemical binding]; other site 941193007079 Walker B motif; other site 941193007080 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 941193007081 Uncharacterized conserved protein [Function unknown]; Region: COG3791 941193007082 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 941193007083 dimer interface [polypeptide binding]; other site 941193007084 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 941193007085 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 941193007086 potential catalytic triad [active] 941193007087 conserved cys residue [active] 941193007088 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 941193007089 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 941193007090 DNA binding residues [nucleotide binding] 941193007091 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 941193007092 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 941193007093 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 941193007094 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 941193007095 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 941193007096 putative active site [active] 941193007097 putative FMN binding site [chemical binding]; other site 941193007098 putative substrate binding site [chemical binding]; other site 941193007099 putative catalytic residue [active] 941193007100 Ferredoxin [Energy production and conversion]; Region: COG1146 941193007101 4Fe-4S binding domain; Region: Fer4; cl02805 941193007102 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 941193007103 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 941193007104 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 941193007105 putative [Fe4-S4] binding site [ion binding]; other site 941193007106 putative molybdopterin cofactor binding site [chemical binding]; other site 941193007107 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 941193007108 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 941193007109 putative molybdopterin cofactor binding site; other site 941193007110 Predicted transcriptional regulators [Transcription]; Region: COG1733 941193007111 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 941193007112 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 941193007113 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 941193007114 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941193007115 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 941193007116 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 941193007117 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 941193007118 dimer interface [polypeptide binding]; other site 941193007119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193007120 catalytic residue [active] 941193007121 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 941193007122 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 941193007123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193007124 Walker A motif; other site 941193007125 ATP binding site [chemical binding]; other site 941193007126 Walker B motif; other site 941193007127 arginine finger; other site 941193007128 Uncharacterized conserved protein [Function unknown]; Region: COG3791 941193007129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 941193007130 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 941193007131 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941193007132 Tse2 immunity protein Tsi2 and similar proteins; Region: Tsi2_like; cd11690 941193007133 dimer interface [polypeptide binding]; other site 941193007134 Transmembrane secretion effector; Region: MFS_3; pfam05977 941193007135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193007136 putative substrate translocation pore; other site 941193007137 outer membrane porin, OprD family; Region: OprD; pfam03573 941193007138 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 941193007139 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 941193007140 active site 941193007141 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 941193007142 Isochorismatase family; Region: Isochorismatase; pfam00857 941193007143 catalytic triad [active] 941193007144 dimer interface [polypeptide binding]; other site 941193007145 conserved cis-peptide bond; other site 941193007146 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 941193007147 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193007148 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941193007149 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193007150 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 941193007151 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 941193007152 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 941193007153 catalytic residues [active] 941193007154 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 941193007155 Predicted transcriptional regulator [Transcription]; Region: COG1959 941193007156 Transcriptional regulator; Region: Rrf2; pfam02082 941193007157 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 941193007158 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941193007159 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 941193007160 outer membrane receptor FepA; Provisional; Region: PRK13524 941193007161 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193007162 N-terminal plug; other site 941193007163 ligand-binding site [chemical binding]; other site 941193007164 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941193007165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193007166 phosphorylation site [posttranslational modification] 941193007167 dimer interface [polypeptide binding]; other site 941193007168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193007169 ATP binding site [chemical binding]; other site 941193007170 Mg2+ binding site [ion binding]; other site 941193007171 G-X-G motif; other site 941193007172 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941193007173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193007174 active site 941193007175 phosphorylation site [posttranslational modification] 941193007176 intermolecular recognition site; other site 941193007177 dimerization interface [polypeptide binding]; other site 941193007178 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193007179 DNA binding site [nucleotide binding] 941193007180 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 941193007181 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 941193007182 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 941193007183 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 941193007184 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 941193007185 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 941193007186 RHS Repeat; Region: RHS_repeat; pfam05593 941193007187 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 941193007188 RHS Repeat; Region: RHS_repeat; pfam05593 941193007189 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 941193007190 RHS Repeat; Region: RHS_repeat; pfam05593 941193007191 RHS Repeat; Region: RHS_repeat; cl11982 941193007192 RHS protein; Region: RHS; pfam03527 941193007193 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 941193007194 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 941193007195 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 941193007196 tetramer interface [polypeptide binding]; other site 941193007197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193007198 catalytic residue [active] 941193007199 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 941193007200 SnoaL-like domain; Region: SnoaL_2; pfam12680 941193007201 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193007202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193007203 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941193007204 putative effector binding pocket; other site 941193007205 dimerization interface [polypeptide binding]; other site 941193007206 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 941193007207 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 941193007208 NADP binding site [chemical binding]; other site 941193007209 dimer interface [polypeptide binding]; other site 941193007210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193007211 S-adenosylmethionine binding site [chemical binding]; other site 941193007212 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 941193007213 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 941193007214 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 941193007215 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 941193007216 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 941193007217 Walker A motif; other site 941193007218 ATP binding site [chemical binding]; other site 941193007219 Walker B motif; other site 941193007220 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 941193007221 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 941193007222 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 941193007223 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 941193007224 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 941193007225 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 941193007226 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 941193007227 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 941193007228 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 941193007229 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 941193007230 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 941193007231 active site 941193007232 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 941193007233 GAF domain; Region: GAF; pfam01590 941193007234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193007235 Walker A motif; other site 941193007236 ATP binding site [chemical binding]; other site 941193007237 Walker B motif; other site 941193007238 arginine finger; other site 941193007239 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 941193007240 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 941193007241 heme-binding site [chemical binding]; other site 941193007242 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 941193007243 FAD binding pocket [chemical binding]; other site 941193007244 FAD binding motif [chemical binding]; other site 941193007245 phosphate binding motif [ion binding]; other site 941193007246 beta-alpha-beta structure motif; other site 941193007247 NAD binding pocket [chemical binding]; other site 941193007248 Heme binding pocket [chemical binding]; other site 941193007249 Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213 941193007250 hypothetical protein; Provisional; Region: PRK10318 941193007251 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 941193007252 Predicted membrane protein [Function unknown]; Region: COG3212 941193007253 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 941193007254 Predicted membrane protein [Function unknown]; Region: COG3212 941193007255 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941193007256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193007257 active site 941193007258 phosphorylation site [posttranslational modification] 941193007259 intermolecular recognition site; other site 941193007260 dimerization interface [polypeptide binding]; other site 941193007261 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193007262 DNA binding site [nucleotide binding] 941193007263 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941193007264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193007265 ATP binding site [chemical binding]; other site 941193007266 Mg2+ binding site [ion binding]; other site 941193007267 G-X-G motif; other site 941193007268 Cache domain; Region: Cache_1; pfam02743 941193007269 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193007270 dimerization interface [polypeptide binding]; other site 941193007271 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941193007272 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193007273 dimer interface [polypeptide binding]; other site 941193007274 putative CheW interface [polypeptide binding]; other site 941193007275 Predicted permease [General function prediction only]; Region: COG2056 941193007276 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 941193007277 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 941193007278 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193007279 dimerization interface [polypeptide binding]; other site 941193007280 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941193007281 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193007282 dimer interface [polypeptide binding]; other site 941193007283 putative CheW interface [polypeptide binding]; other site 941193007284 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 941193007285 Domain of unknown function DUF20; Region: UPF0118; pfam01594 941193007286 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 941193007287 hypothetical protein; Reviewed; Region: PRK09588 941193007288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193007289 S-adenosylmethionine binding site [chemical binding]; other site 941193007290 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 941193007291 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 941193007292 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 941193007293 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 941193007294 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 941193007295 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 941193007296 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 941193007297 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 941193007298 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 941193007299 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 941193007300 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 941193007301 4Fe-4S binding domain; Region: Fer4; pfam00037 941193007302 4Fe-4S binding domain; Region: Fer4; pfam00037 941193007303 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 941193007304 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 941193007305 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941193007306 catalytic loop [active] 941193007307 iron binding site [ion binding]; other site 941193007308 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 941193007309 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 941193007310 [4Fe-4S] binding site [ion binding]; other site 941193007311 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 941193007312 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 941193007313 SLBB domain; Region: SLBB; pfam10531 941193007314 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 941193007315 NADH dehydrogenase subunit E; Validated; Region: PRK07539 941193007316 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 941193007317 putative dimer interface [polypeptide binding]; other site 941193007318 [2Fe-2S] cluster binding site [ion binding]; other site 941193007319 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 941193007320 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 941193007321 NADH dehydrogenase subunit D; Validated; Region: PRK06075 941193007322 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 941193007323 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 941193007324 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 941193007325 CoenzymeA binding site [chemical binding]; other site 941193007326 subunit interaction site [polypeptide binding]; other site 941193007327 PHB binding site; other site 941193007328 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 941193007329 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 941193007330 tetramer interface [polypeptide binding]; other site 941193007331 active site 941193007332 Mg2+/Mn2+ binding site [ion binding]; other site 941193007333 isocitrate lyase; Region: PLN02892 941193007334 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 941193007335 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 941193007336 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 941193007337 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941193007338 Coenzyme A binding pocket [chemical binding]; other site 941193007339 Uncharacterized conserved protein [Function unknown]; Region: COG2850 941193007340 Cupin domain; Region: Cupin_2; cl17218 941193007341 adenylosuccinate lyase; Provisional; Region: PRK09285 941193007342 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 941193007343 tetramer interface [polypeptide binding]; other site 941193007344 active site 941193007345 EamA-like transporter family; Region: EamA; pfam00892 941193007346 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 941193007347 Uncharacterized protein involved in purine metabolism [General function prediction only]; Region: COG2915 941193007348 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 941193007349 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 941193007350 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 941193007351 nudix motif; other site 941193007352 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 941193007353 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 941193007354 isocitrate dehydrogenase; Validated; Region: PRK07362 941193007355 isocitrate dehydrogenase; Reviewed; Region: PRK07006 941193007356 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 941193007357 DNA-binding site [nucleotide binding]; DNA binding site 941193007358 RNA-binding motif; other site 941193007359 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 941193007360 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 941193007361 Clp amino terminal domain; Region: Clp_N; pfam02861 941193007362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193007363 Walker A motif; other site 941193007364 ATP binding site [chemical binding]; other site 941193007365 Walker B motif; other site 941193007366 arginine finger; other site 941193007367 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193007368 Walker A motif; other site 941193007369 ATP binding site [chemical binding]; other site 941193007370 Walker B motif; other site 941193007371 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 941193007372 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 941193007373 rRNA binding site [nucleotide binding]; other site 941193007374 predicted 30S ribosome binding site; other site 941193007375 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 941193007376 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 941193007377 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 941193007378 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 941193007379 thioredoxin reductase; Provisional; Region: PRK10262 941193007380 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941193007381 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941193007382 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 941193007383 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 941193007384 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 941193007385 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 941193007386 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 941193007387 recombination factor protein RarA; Reviewed; Region: PRK13342 941193007388 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193007389 Walker A motif; other site 941193007390 ATP binding site [chemical binding]; other site 941193007391 Walker B motif; other site 941193007392 arginine finger; other site 941193007393 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 941193007394 seryl-tRNA synthetase; Provisional; Region: PRK05431 941193007395 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 941193007396 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 941193007397 dimer interface [polypeptide binding]; other site 941193007398 active site 941193007399 motif 1; other site 941193007400 motif 2; other site 941193007401 motif 3; other site 941193007402 siroheme synthase; Provisional; Region: cysG; PRK10637 941193007403 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 941193007404 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 941193007405 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 941193007406 active site 941193007407 SAM binding site [chemical binding]; other site 941193007408 homodimer interface [polypeptide binding]; other site 941193007409 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 941193007410 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 941193007411 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 941193007412 putative dimer interface [polypeptide binding]; other site 941193007413 N-terminal domain interface [polypeptide binding]; other site 941193007414 putative substrate binding pocket (H-site) [chemical binding]; other site 941193007415 hypothetical protein; Validated; Region: PRK09071 941193007416 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 941193007417 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 941193007418 DsrC like protein; Region: DsrC; cl01101 941193007419 sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011 941193007420 sulfur relay protein TusC; Validated; Region: PRK00211 941193007421 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 941193007422 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 941193007423 YccA-like proteins; Region: YccA_like; cd10433 941193007424 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 941193007425 active site residue [active] 941193007426 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 941193007427 active site residue [active] 941193007428 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 941193007429 active site residue [active] 941193007430 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 941193007431 active site residue [active] 941193007432 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 941193007433 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193007434 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193007435 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941193007436 dimerization interface [polypeptide binding]; other site 941193007437 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 941193007438 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 941193007439 dimer interface [polypeptide binding]; other site 941193007440 active site 941193007441 non-prolyl cis peptide bond; other site 941193007442 insertion regions; other site 941193007443 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 941193007444 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193007445 substrate binding pocket [chemical binding]; other site 941193007446 membrane-bound complex binding site; other site 941193007447 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 941193007448 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 941193007449 dimer interface [polypeptide binding]; other site 941193007450 active site 941193007451 non-prolyl cis peptide bond; other site 941193007452 insertion regions; other site 941193007453 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941193007454 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 941193007455 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 941193007456 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193007457 substrate binding pocket [chemical binding]; other site 941193007458 membrane-bound complex binding site; other site 941193007459 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193007460 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 941193007461 membrane-bound complex binding site; other site 941193007462 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 941193007463 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193007464 substrate binding pocket [chemical binding]; other site 941193007465 membrane-bound complex binding site; other site 941193007466 hinge residues; other site 941193007467 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 941193007468 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 941193007469 malonyl-CoA binding site [chemical binding]; other site 941193007470 dimer interface [polypeptide binding]; other site 941193007471 active site 941193007472 product binding site; other site 941193007473 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 941193007474 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193007475 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193007476 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941193007477 putative effector binding pocket; other site 941193007478 dimerization interface [polypeptide binding]; other site 941193007479 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 941193007480 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 941193007481 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941193007482 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 941193007483 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 941193007484 active site 941193007485 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 941193007486 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 941193007487 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 941193007488 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 941193007489 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 941193007490 active site 941193007491 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 941193007492 NADP binding site [chemical binding]; other site 941193007493 active site 941193007494 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 941193007495 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 941193007496 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 941193007497 active site 941193007498 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 941193007499 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 941193007500 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 941193007501 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 941193007502 NADP binding site [chemical binding]; other site 941193007503 active site 941193007504 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941193007505 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 941193007506 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941193007507 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193007508 active site 941193007509 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 941193007510 AMP-binding enzyme; Region: AMP-binding; pfam00501 941193007511 acyl-activating enzyme (AAE) consensus motif; other site 941193007512 AMP binding site [chemical binding]; other site 941193007513 Thioesterase domain; Region: Thioesterase; pfam00975 941193007514 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193007515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193007516 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 941193007517 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 941193007518 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193007519 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193007520 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941193007521 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 941193007522 Walker A/P-loop; other site 941193007523 ATP binding site [chemical binding]; other site 941193007524 Q-loop/lid; other site 941193007525 ABC transporter signature motif; other site 941193007526 Walker B; other site 941193007527 D-loop; other site 941193007528 H-loop/switch region; other site 941193007529 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 941193007530 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 941193007531 Walker A/P-loop; other site 941193007532 ATP binding site [chemical binding]; other site 941193007533 Q-loop/lid; other site 941193007534 ABC transporter signature motif; other site 941193007535 Walker B; other site 941193007536 D-loop; other site 941193007537 H-loop/switch region; other site 941193007538 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 941193007539 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 941193007540 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 941193007541 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 941193007542 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 941193007543 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 941193007544 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 941193007545 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941193007546 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941193007547 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193007548 DNA binding residues [nucleotide binding] 941193007549 dimerization interface [polypeptide binding]; other site 941193007550 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 941193007551 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193007552 N-terminal plug; other site 941193007553 ligand-binding site [chemical binding]; other site 941193007554 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 941193007555 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 941193007556 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 941193007557 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941193007558 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193007559 hypothetical protein; Provisional; Region: PRK06753 941193007560 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 941193007561 response regulator; Provisional; Region: PRK09483 941193007562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193007563 active site 941193007564 phosphorylation site [posttranslational modification] 941193007565 intermolecular recognition site; other site 941193007566 dimerization interface [polypeptide binding]; other site 941193007567 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193007568 DNA binding residues [nucleotide binding] 941193007569 dimerization interface [polypeptide binding]; other site 941193007570 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 941193007571 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 941193007572 GIY-YIG motif/motif A; other site 941193007573 active site 941193007574 catalytic site [active] 941193007575 putative DNA binding site [nucleotide binding]; other site 941193007576 metal binding site [ion binding]; metal-binding site 941193007577 UvrB/uvrC motif; Region: UVR; pfam02151 941193007578 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 941193007579 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 941193007580 DNA binding site [nucleotide binding] 941193007581 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 941193007582 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 941193007583 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193007584 substrate binding pocket [chemical binding]; other site 941193007585 membrane-bound complex binding site; other site 941193007586 hinge residues; other site 941193007587 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941193007588 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193007589 substrate binding pocket [chemical binding]; other site 941193007590 membrane-bound complex binding site; other site 941193007591 hinge residues; other site 941193007592 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193007593 dimer interface [polypeptide binding]; other site 941193007594 phosphorylation site [posttranslational modification] 941193007595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193007596 ATP binding site [chemical binding]; other site 941193007597 Mg2+ binding site [ion binding]; other site 941193007598 G-X-G motif; other site 941193007599 Response regulator receiver domain; Region: Response_reg; pfam00072 941193007600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193007601 active site 941193007602 phosphorylation site [posttranslational modification] 941193007603 intermolecular recognition site; other site 941193007604 dimerization interface [polypeptide binding]; other site 941193007605 Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109 941193007606 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 941193007607 putative RNA binding sites [nucleotide binding]; other site 941193007608 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 941193007609 Tryptophan 2,3-dioxygenase (vermilion) [Amino acid transport and metabolism]; Region: TDO2; COG3483 941193007610 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 941193007611 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 941193007612 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941193007613 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 941193007614 putative DNA binding site [nucleotide binding]; other site 941193007615 putative Zn2+ binding site [ion binding]; other site 941193007616 AsnC family; Region: AsnC_trans_reg; pfam01037 941193007617 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 941193007618 EamA-like transporter family; Region: EamA; pfam00892 941193007619 EamA-like transporter family; Region: EamA; pfam00892 941193007620 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 941193007621 dimer interface [polypeptide binding]; other site 941193007622 FMN binding site [chemical binding]; other site 941193007623 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 941193007624 Fatty acid desaturase; Region: FA_desaturase; pfam00487 941193007625 Di-iron ligands [ion binding]; other site 941193007626 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 941193007627 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193007628 dimerization interface [polypeptide binding]; other site 941193007629 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193007630 dimer interface [polypeptide binding]; other site 941193007631 putative CheW interface [polypeptide binding]; other site 941193007632 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 941193007633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193007634 active site 941193007635 phosphorylation site [posttranslational modification] 941193007636 intermolecular recognition site; other site 941193007637 dimerization interface [polypeptide binding]; other site 941193007638 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941193007639 Zn2+ binding site [ion binding]; other site 941193007640 Mg2+ binding site [ion binding]; other site 941193007641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193007642 ATP binding site [chemical binding]; other site 941193007643 Mg2+ binding site [ion binding]; other site 941193007644 G-X-G motif; other site 941193007645 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 941193007646 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 941193007647 active site 941193007648 DNA binding site [nucleotide binding] 941193007649 Int/Topo IB signature motif; other site 941193007650 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 941193007651 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 941193007652 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 941193007653 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 941193007654 substrate interaction site [chemical binding]; other site 941193007655 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 941193007656 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 941193007657 Global regulator protein family; Region: CsrA; pfam02599 941193007658 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 941193007659 Predicted transcriptional regulator [Transcription]; Region: COG2932 941193007660 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 941193007661 Catalytic site [active] 941193007662 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 941193007663 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 941193007664 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 941193007665 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 941193007666 Predicted chitinase [General function prediction only]; Region: COG3179 941193007667 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 941193007668 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 941193007669 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 941193007670 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 941193007671 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 941193007672 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 941193007673 oligomer interface [polypeptide binding]; other site 941193007674 active site residues [active] 941193007675 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 941193007676 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 941193007677 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 941193007678 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 941193007679 putative sugar binding sites [chemical binding]; other site 941193007680 Q-X-W motif; other site 941193007681 tape measure domain; Region: tape_meas_nterm; TIGR02675 941193007682 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 941193007683 DNA-binding site [nucleotide binding]; DNA binding site 941193007684 RNA-binding motif; other site 941193007685 PA-IL-like protein; Region: PA-IL; pfam07828 941193007686 GAF domain; Region: GAF; pfam01590 941193007687 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 941193007688 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193007689 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193007690 metal binding site [ion binding]; metal-binding site 941193007691 active site 941193007692 I-site; other site 941193007693 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941193007694 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 941193007695 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 941193007696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193007697 S-adenosylmethionine binding site [chemical binding]; other site 941193007698 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 941193007699 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 941193007700 Sulfate transporter family; Region: Sulfate_transp; pfam00916 941193007701 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 941193007702 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 941193007703 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193007704 dimerization interface [polypeptide binding]; other site 941193007705 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941193007706 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193007707 dimer interface [polypeptide binding]; other site 941193007708 putative CheW interface [polypeptide binding]; other site 941193007709 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 941193007710 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 941193007711 MgtC family; Region: MgtC; pfam02308 941193007712 AMP-binding domain protein; Validated; Region: PRK08315 941193007713 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 941193007714 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 941193007715 acyl-activating enzyme (AAE) consensus motif; other site 941193007716 putative AMP binding site [chemical binding]; other site 941193007717 putative active site [active] 941193007718 putative CoA binding site [chemical binding]; other site 941193007719 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 941193007720 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941193007721 SurA N-terminal domain; Region: SurA_N; pfam09312 941193007722 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193007723 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 941193007724 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 941193007725 acyl-activating enzyme (AAE) consensus motif; other site 941193007726 AMP binding site [chemical binding]; other site 941193007727 active site 941193007728 CoA binding site [chemical binding]; other site 941193007729 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 941193007730 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 941193007731 NAD binding site [chemical binding]; other site 941193007732 homodimer interface [polypeptide binding]; other site 941193007733 homotetramer interface [polypeptide binding]; other site 941193007734 active site 941193007735 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 941193007736 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 941193007737 dimer interface [polypeptide binding]; other site 941193007738 active site 941193007739 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193007740 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941193007741 active site 941193007742 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 941193007743 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193007744 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 941193007745 substrate binding pocket [chemical binding]; other site 941193007746 dimerization interface [polypeptide binding]; other site 941193007747 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941193007748 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 941193007749 FAD binding site [chemical binding]; other site 941193007750 substrate binding site [chemical binding]; other site 941193007751 catalytic base [active] 941193007752 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 941193007753 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 941193007754 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 941193007755 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 941193007756 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 941193007757 ligand binding site [chemical binding]; other site 941193007758 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193007759 LysR family transcriptional regulator; Provisional; Region: PRK14997 941193007760 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941193007761 putative effector binding pocket; other site 941193007762 dimerization interface [polypeptide binding]; other site 941193007763 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 941193007764 dimer interface [polypeptide binding]; other site 941193007765 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941193007766 metal binding site [ion binding]; metal-binding site 941193007767 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 941193007768 putative catalytic site [active] 941193007769 putative phosphate binding site [ion binding]; other site 941193007770 active site 941193007771 metal binding site A [ion binding]; metal-binding site 941193007772 DNA binding site [nucleotide binding] 941193007773 putative AP binding site [nucleotide binding]; other site 941193007774 putative metal binding site B [ion binding]; other site 941193007775 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 941193007776 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 941193007777 Coenzyme A binding pocket [chemical binding]; other site 941193007778 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 941193007779 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 941193007780 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 941193007781 Surface antigen; Region: Bac_surface_Ag; pfam01103 941193007782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 941193007783 Family of unknown function (DUF490); Region: DUF490; pfam04357 941193007784 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 941193007785 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 941193007786 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 941193007787 Putative methyltransferase; Region: Methyltransf_20; pfam12147 941193007788 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 941193007789 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 941193007790 active site 941193007791 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 941193007792 active site 941193007793 catalytic residues [active] 941193007794 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 941193007795 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 941193007796 putative acyl-acceptor binding pocket; other site 941193007797 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 941193007798 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 941193007799 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 941193007800 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 941193007801 active site 941193007802 catalytic tetrad [active] 941193007803 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193007804 LysR family transcriptional regulator; Provisional; Region: PRK14997 941193007805 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 941193007806 putative effector binding pocket; other site 941193007807 putative dimerization interface [polypeptide binding]; other site 941193007808 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 941193007809 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 941193007810 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 941193007811 dimer interface [polypeptide binding]; other site 941193007812 catalytic triad [active] 941193007813 peroxidatic and resolving cysteines [active] 941193007814 putative aminotransferase; Provisional; Region: PRK09105 941193007815 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941193007816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193007817 homodimer interface [polypeptide binding]; other site 941193007818 catalytic residue [active] 941193007819 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 941193007820 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 941193007821 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 941193007822 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193007823 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193007824 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 941193007825 Protein export membrane protein; Region: SecD_SecF; cl14618 941193007826 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 941193007827 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 941193007828 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 941193007829 synaptic vesicle protein SV2; Region: synapt_SV2; TIGR01299 941193007830 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 941193007831 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193007832 dimerization interface [polypeptide binding]; other site 941193007833 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193007834 dimer interface [polypeptide binding]; other site 941193007835 phosphorylation site [posttranslational modification] 941193007836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193007837 ATP binding site [chemical binding]; other site 941193007838 Mg2+ binding site [ion binding]; other site 941193007839 G-X-G motif; other site 941193007840 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 941193007841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193007842 active site 941193007843 phosphorylation site [posttranslational modification] 941193007844 intermolecular recognition site; other site 941193007845 dimerization interface [polypeptide binding]; other site 941193007846 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193007847 DNA binding site [nucleotide binding] 941193007848 Outer membrane efflux protein; Region: OEP; pfam02321 941193007849 Outer membrane efflux protein; Region: OEP; pfam02321 941193007850 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193007851 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 941193007852 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193007853 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 941193007854 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 941193007855 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193007856 Helix-turn-helix domain; Region: HTH_18; pfam12833 941193007857 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193007858 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 941193007859 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 941193007860 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 941193007861 putative alpha subunit interface [polypeptide binding]; other site 941193007862 putative active site [active] 941193007863 putative substrate binding site [chemical binding]; other site 941193007864 Fe binding site [ion binding]; other site 941193007865 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 941193007866 inter-subunit interface; other site 941193007867 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 941193007868 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941193007869 catalytic loop [active] 941193007870 iron binding site [ion binding]; other site 941193007871 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 941193007872 FAD binding pocket [chemical binding]; other site 941193007873 FAD binding motif [chemical binding]; other site 941193007874 phosphate binding motif [ion binding]; other site 941193007875 beta-alpha-beta structure motif; other site 941193007876 NAD binding pocket [chemical binding]; other site 941193007877 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 941193007878 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 941193007879 putative NAD(P) binding site [chemical binding]; other site 941193007880 active site 941193007881 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 941193007882 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941193007883 catalytic loop [active] 941193007884 iron binding site [ion binding]; other site 941193007885 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 941193007886 FAD binding pocket [chemical binding]; other site 941193007887 FAD binding motif [chemical binding]; other site 941193007888 phosphate binding motif [ion binding]; other site 941193007889 beta-alpha-beta structure motif; other site 941193007890 NAD binding pocket [chemical binding]; other site 941193007891 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 941193007892 inter-subunit interface; other site 941193007893 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 941193007894 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 941193007895 [2Fe-2S] cluster binding site [ion binding]; other site 941193007896 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 941193007897 putative alpha subunit interface [polypeptide binding]; other site 941193007898 putative active site [active] 941193007899 putative substrate binding site [chemical binding]; other site 941193007900 Fe binding site [ion binding]; other site 941193007901 Helix-turn-helix domain; Region: HTH_18; pfam12833 941193007902 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 941193007903 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193007904 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193007905 dimerization interface [polypeptide binding]; other site 941193007906 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 941193007907 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 941193007908 octamer interface [polypeptide binding]; other site 941193007909 active site 941193007910 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 941193007911 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 941193007912 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 941193007913 dimer interface [polypeptide binding]; other site 941193007914 active site 941193007915 outer membrane porin, OprD family; Region: OprD; pfam03573 941193007916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4859 941193007917 Leucine rich repeat; Region: LRR_8; pfam13855 941193007918 Leucine rich repeat; Region: LRR_8; pfam13855 941193007919 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 941193007920 active site 941193007921 ATP binding site [chemical binding]; other site 941193007922 substrate binding site [chemical binding]; other site 941193007923 activation loop (A-loop); other site 941193007924 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 941193007925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193007926 putative substrate translocation pore; other site 941193007927 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 941193007928 nucleoside/Zn binding site; other site 941193007929 dimer interface [polypeptide binding]; other site 941193007930 catalytic motif [active] 941193007931 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 941193007932 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 941193007933 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 941193007934 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 941193007935 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193007936 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193007937 dimerization interface [polypeptide binding]; other site 941193007938 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 941193007939 DinB superfamily; Region: DinB_2; pfam12867 941193007940 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 941193007941 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 941193007942 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 941193007943 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193007944 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193007945 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193007946 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193007947 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 941193007948 putative substrate binding pocket [chemical binding]; other site 941193007949 putative dimerization interface [polypeptide binding]; other site 941193007950 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 941193007951 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 941193007952 putative NAD(P) binding site [chemical binding]; other site 941193007953 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 941193007954 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 941193007955 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941193007956 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941193007957 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193007958 acyl-CoA dehydrogenase; Provisional; Region: PTZ00460 941193007959 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193007960 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193007961 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 941193007962 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 941193007963 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 941193007964 Cytochrome c553 [Energy production and conversion]; Region: COG2863 941193007965 Cytochrome c; Region: Cytochrom_C; cl11414 941193007966 Cytochrome c [Energy production and conversion]; Region: COG3258 941193007967 Cytochrome c; Region: Cytochrom_C; pfam00034 941193007968 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941193007969 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193007970 dimer interface [polypeptide binding]; other site 941193007971 phosphorylation site [posttranslational modification] 941193007972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193007973 ATP binding site [chemical binding]; other site 941193007974 G-X-G motif; other site 941193007975 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 941193007976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193007977 active site 941193007978 phosphorylation site [posttranslational modification] 941193007979 intermolecular recognition site; other site 941193007980 dimerization interface [polypeptide binding]; other site 941193007981 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193007982 DNA binding site [nucleotide binding] 941193007983 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 941193007984 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 941193007985 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 941193007986 DsbD alpha interface [polypeptide binding]; other site 941193007987 catalytic residues [active] 941193007988 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 941193007989 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 941193007990 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 941193007991 catalytic residues [active] 941193007992 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 941193007993 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 941193007994 dimerization domain [polypeptide binding]; other site 941193007995 dimer interface [polypeptide binding]; other site 941193007996 catalytic residues [active] 941193007997 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 941193007998 Cytochrome P450; Region: p450; cl12078 941193007999 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 941193008000 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 941193008001 maleylacetoacetate isomerase; Region: maiA; TIGR01262 941193008002 C-terminal domain interface [polypeptide binding]; other site 941193008003 GSH binding site (G-site) [chemical binding]; other site 941193008004 putative dimer interface [polypeptide binding]; other site 941193008005 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 941193008006 dimer interface [polypeptide binding]; other site 941193008007 N-terminal domain interface [polypeptide binding]; other site 941193008008 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 941193008009 benzoate transport; Region: 2A0115; TIGR00895 941193008010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193008011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193008012 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 941193008013 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 941193008014 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 941193008015 Cupin domain; Region: Cupin_2; pfam07883 941193008016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193008017 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 941193008018 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193008019 dimerization interface [polypeptide binding]; other site 941193008020 RNA polymerase sigma factor; Provisional; Region: PRK12528 941193008021 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941193008022 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941193008023 DNA binding residues [nucleotide binding] 941193008024 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 941193008025 FecR protein; Region: FecR; pfam04773 941193008026 Secretin and TonB N terminus short domain; Region: STN; smart00965 941193008027 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 941193008028 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193008029 N-terminal plug; other site 941193008030 ligand-binding site [chemical binding]; other site 941193008031 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 941193008032 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 941193008033 RHS Repeat; Region: RHS_repeat; pfam05593 941193008034 RHS Repeat; Region: RHS_repeat; pfam05593 941193008035 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 941193008036 RHS Repeat; Region: RHS_repeat; pfam05593 941193008037 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 941193008038 RHS Repeat; Region: RHS_repeat; pfam05593 941193008039 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 941193008040 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 941193008041 RHS Repeat; Region: RHS_repeat; pfam05593 941193008042 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 941193008043 RHS Repeat; Region: RHS_repeat; cl11982 941193008044 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941193008045 Coenzyme A binding pocket [chemical binding]; other site 941193008046 Methyltransferase domain; Region: Methyltransf_31; pfam13847 941193008047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193008048 S-adenosylmethionine binding site [chemical binding]; other site 941193008049 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 941193008050 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 941193008051 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 941193008052 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 941193008053 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 941193008054 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 941193008055 putative aromatic amino acid binding site; other site 941193008056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193008057 Walker A motif; other site 941193008058 ATP binding site [chemical binding]; other site 941193008059 Walker B motif; other site 941193008060 arginine finger; other site 941193008061 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 941193008062 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 941193008063 active site 941193008064 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193008065 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193008066 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941193008067 dimerization interface [polypeptide binding]; other site 941193008068 putative effector binding pocket; other site 941193008069 glycine cleavage system protein H; Provisional; Region: PRK13380 941193008070 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 941193008071 lipoyl attachment site [posttranslational modification]; other site 941193008072 glycine dehydrogenase; Provisional; Region: PRK05367 941193008073 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 941193008074 tetramer interface [polypeptide binding]; other site 941193008075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193008076 catalytic residue [active] 941193008077 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 941193008078 tetramer interface [polypeptide binding]; other site 941193008079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193008080 catalytic residue [active] 941193008081 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 941193008082 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 941193008083 dimer interface [polypeptide binding]; other site 941193008084 active site 941193008085 glycine-pyridoxal phosphate binding site [chemical binding]; other site 941193008086 folate binding site [chemical binding]; other site 941193008087 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 941193008088 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 941193008089 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 941193008090 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 941193008091 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 941193008092 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The...; Region: SANT; cl17250 941193008093 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 941193008094 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 941193008095 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 941193008096 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 941193008097 HflC protein; Region: hflC; TIGR01932 941193008098 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 941193008099 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 941193008100 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 941193008101 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941193008102 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193008103 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193008104 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941193008105 putative effector binding pocket; other site 941193008106 dimerization interface [polypeptide binding]; other site 941193008107 Fusaric acid resistance protein family; Region: FUSC; pfam04632 941193008108 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 941193008109 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 941193008110 multidrug resistance protein MdtN; Provisional; Region: PRK10476 941193008111 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193008112 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193008113 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 941193008114 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 941193008115 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 941193008116 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 941193008117 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941193008118 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941193008119 DNA binding residues [nucleotide binding] 941193008120 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 941193008121 peptide synthase; Validated; Region: PRK05691 941193008122 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 941193008123 acyl-activating enzyme (AAE) consensus motif; other site 941193008124 active site 941193008125 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941193008126 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 941193008127 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 941193008128 acyl-activating enzyme (AAE) consensus motif; other site 941193008129 AMP binding site [chemical binding]; other site 941193008130 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941193008131 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 941193008132 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 941193008133 acyl-activating enzyme (AAE) consensus motif; other site 941193008134 AMP binding site [chemical binding]; other site 941193008135 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941193008136 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 941193008137 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 941193008138 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 941193008139 acyl-activating enzyme (AAE) consensus motif; other site 941193008140 AMP binding site [chemical binding]; other site 941193008141 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941193008142 Prophage antirepressor [Transcription]; Region: COG3617 941193008143 BRO family, N-terminal domain; Region: Bro-N; smart01040 941193008144 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 941193008145 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 941193008146 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736 941193008147 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735 941193008148 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 941193008149 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 941193008150 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 941193008151 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 941193008152 outer membrane porin, OprD family; Region: OprD; pfam03573 941193008153 Isochorismatase family; Region: Isochorismatase; pfam00857 941193008154 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 941193008155 catalytic triad [active] 941193008156 dimer interface [polypeptide binding]; other site 941193008157 conserved cis-peptide bond; other site 941193008158 Pirin-related protein [General function prediction only]; Region: COG1741 941193008159 Pirin; Region: Pirin; pfam02678 941193008160 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 941193008161 LysR family transcriptional regulator; Provisional; Region: PRK14997 941193008162 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193008163 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 941193008164 putative effector binding pocket; other site 941193008165 putative dimerization interface [polypeptide binding]; other site 941193008166 trehalase; Provisional; Region: treA; PRK13272 941193008167 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 941193008168 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 941193008169 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 941193008170 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 941193008171 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941193008172 inhibitor-cofactor binding pocket; inhibition site 941193008173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193008174 catalytic residue [active] 941193008175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 941193008176 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 941193008177 Serine hydrolase; Region: Ser_hydrolase; cl17834 941193008178 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 941193008179 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 941193008180 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 941193008181 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941193008182 ABC-ATPase subunit interface; other site 941193008183 dimer interface [polypeptide binding]; other site 941193008184 putative PBP binding regions; other site 941193008185 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 941193008186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193008187 Walker A/P-loop; other site 941193008188 ATP binding site [chemical binding]; other site 941193008189 Q-loop/lid; other site 941193008190 ABC transporter signature motif; other site 941193008191 Walker B; other site 941193008192 D-loop; other site 941193008193 H-loop/switch region; other site 941193008194 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 941193008195 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 941193008196 intersubunit interface [polypeptide binding]; other site 941193008197 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 941193008198 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 941193008199 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 941193008200 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 941193008201 Condensation domain; Region: Condensation; pfam00668 941193008202 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 941193008203 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 941193008204 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 941193008205 acyl-activating enzyme (AAE) consensus motif; other site 941193008206 AMP binding site [chemical binding]; other site 941193008207 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941193008208 Condensation domain; Region: Condensation; pfam00668 941193008209 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 941193008210 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 941193008211 Condensation domain; Region: Condensation; pfam00668 941193008212 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 941193008213 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 941193008214 acyl-activating enzyme (AAE) consensus motif; other site 941193008215 AMP binding site [chemical binding]; other site 941193008216 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941193008217 Condensation domain; Region: Condensation; pfam00668 941193008218 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 941193008219 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 941193008220 Condensation domain; Region: Condensation; pfam00668 941193008221 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 941193008222 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 941193008223 acyl-activating enzyme (AAE) consensus motif; other site 941193008224 AMP binding site [chemical binding]; other site 941193008225 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941193008226 peptide synthase; Provisional; Region: PRK12467 941193008227 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 941193008228 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 941193008229 acyl-activating enzyme (AAE) consensus motif; other site 941193008230 AMP binding site [chemical binding]; other site 941193008231 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941193008232 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 941193008233 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 941193008234 acyl-activating enzyme (AAE) consensus motif; other site 941193008235 AMP binding site [chemical binding]; other site 941193008236 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941193008237 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 941193008238 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 941193008239 acyl-activating enzyme (AAE) consensus motif; other site 941193008240 AMP binding site [chemical binding]; other site 941193008241 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941193008242 Condensation domain; Region: Condensation; pfam00668 941193008243 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 941193008244 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 941193008245 acyl-activating enzyme (AAE) consensus motif; other site 941193008246 AMP binding site [chemical binding]; other site 941193008247 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941193008248 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 941193008249 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 941193008250 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 941193008251 Secretin and TonB N terminus short domain; Region: STN; pfam07660 941193008252 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 941193008253 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193008254 N-terminal plug; other site 941193008255 ligand-binding site [chemical binding]; other site 941193008256 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 941193008257 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941193008258 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 941193008259 Walker A/P-loop; other site 941193008260 ATP binding site [chemical binding]; other site 941193008261 Q-loop/lid; other site 941193008262 ABC transporter signature motif; other site 941193008263 Walker B; other site 941193008264 D-loop; other site 941193008265 H-loop/switch region; other site 941193008266 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 941193008267 catalytic site [active] 941193008268 Uncharacterized conserved protein [Function unknown]; Region: COG1262 941193008269 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 941193008270 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 941193008271 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941193008272 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941193008273 catalytic residue [active] 941193008274 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 941193008275 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 941193008276 active site 941193008277 dimer interface [polypeptide binding]; other site 941193008278 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 941193008279 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 941193008280 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 941193008281 Walker A/P-loop; other site 941193008282 ATP binding site [chemical binding]; other site 941193008283 Q-loop/lid; other site 941193008284 ABC transporter signature motif; other site 941193008285 Walker B; other site 941193008286 D-loop; other site 941193008287 H-loop/switch region; other site 941193008288 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 941193008289 FtsX-like permease family; Region: FtsX; pfam02687 941193008290 macrolide transporter subunit MacA; Provisional; Region: PRK11578 941193008291 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193008292 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193008293 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 941193008294 FecR protein; Region: FecR; pfam04773 941193008295 RNA polymerase sigma factor; Reviewed; Region: PRK12527 941193008296 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941193008297 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 941193008298 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 941193008299 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941193008300 Penicillin amidase; Region: Penicil_amidase; pfam01804 941193008301 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 941193008302 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 941193008303 active site 941193008304 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 941193008305 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 941193008306 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 941193008307 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193008308 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193008309 dimerization interface [polypeptide binding]; other site 941193008310 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 941193008311 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 941193008312 phosphate binding site [ion binding]; other site 941193008313 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 941193008314 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 941193008315 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941193008316 catalytic loop [active] 941193008317 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 941193008318 iron binding site [ion binding]; other site 941193008319 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 941193008320 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 941193008321 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 941193008322 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 941193008323 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 941193008324 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 941193008325 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 941193008326 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941193008327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193008328 active site 941193008329 phosphorylation site [posttranslational modification] 941193008330 intermolecular recognition site; other site 941193008331 dimerization interface [polypeptide binding]; other site 941193008332 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193008333 DNA binding residues [nucleotide binding] 941193008334 dimerization interface [polypeptide binding]; other site 941193008335 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 941193008336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 941193008337 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 941193008338 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 941193008339 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 941193008340 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 941193008341 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 941193008342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193008343 Walker A motif; other site 941193008344 ATP binding site [chemical binding]; other site 941193008345 Walker B motif; other site 941193008346 arginine finger; other site 941193008347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193008348 Walker A motif; other site 941193008349 ATP binding site [chemical binding]; other site 941193008350 Walker B motif; other site 941193008351 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 941193008352 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 941193008353 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 941193008354 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 941193008355 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 941193008356 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 941193008357 Protein of unknown function (DUF877); Region: DUF877; pfam05943 941193008358 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 941193008359 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 941193008360 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 941193008361 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 941193008362 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 941193008363 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 941193008364 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 941193008365 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 941193008366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193008367 Walker A motif; other site 941193008368 ATP binding site [chemical binding]; other site 941193008369 Walker B motif; other site 941193008370 arginine finger; other site 941193008371 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 941193008372 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 941193008373 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941193008374 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 941193008375 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 941193008376 active site 941193008377 dimer interface [polypeptide binding]; other site 941193008378 non-prolyl cis peptide bond; other site 941193008379 insertion regions; other site 941193008380 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 941193008381 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 941193008382 Flavin binding site [chemical binding]; other site 941193008383 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 941193008384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193008385 Walker A motif; other site 941193008386 ATP binding site [chemical binding]; other site 941193008387 Walker B motif; other site 941193008388 arginine finger; other site 941193008389 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 941193008390 Predicted ATPase [General function prediction only]; Region: COG1485 941193008391 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193008392 Walker B; other site 941193008393 D-loop; other site 941193008394 H-loop/switch region; other site 941193008395 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 941193008396 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 941193008397 active site 941193008398 catalytic site [active] 941193008399 metal binding site [ion binding]; metal-binding site 941193008400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193008401 dimer interface [polypeptide binding]; other site 941193008402 conserved gate region; other site 941193008403 ABC-ATPase subunit interface; other site 941193008404 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 941193008405 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 941193008406 Walker A/P-loop; other site 941193008407 ATP binding site [chemical binding]; other site 941193008408 Q-loop/lid; other site 941193008409 ABC transporter signature motif; other site 941193008410 Walker B; other site 941193008411 D-loop; other site 941193008412 H-loop/switch region; other site 941193008413 NIL domain; Region: NIL; pfam09383 941193008414 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 941193008415 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 941193008416 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 941193008417 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 941193008418 active site 941193008419 non-prolyl cis peptide bond; other site 941193008420 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 941193008421 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193008422 active site 941193008423 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 941193008424 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193008425 active site 941193008426 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 941193008427 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 941193008428 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 941193008429 putative substrate binding site [chemical binding]; other site 941193008430 putative ATP binding site [chemical binding]; other site 941193008431 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 941193008432 N- and C-terminal domain interface [polypeptide binding]; other site 941193008433 D-xylulose kinase; Region: XylB; TIGR01312 941193008434 active site 941193008435 MgATP binding site [chemical binding]; other site 941193008436 catalytic site [active] 941193008437 metal binding site [ion binding]; metal-binding site 941193008438 xylulose binding site [chemical binding]; other site 941193008439 putative homodimer interface [polypeptide binding]; other site 941193008440 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 941193008441 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 941193008442 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 941193008443 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 941193008444 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 941193008445 Walker A/P-loop; other site 941193008446 ATP binding site [chemical binding]; other site 941193008447 Q-loop/lid; other site 941193008448 ABC transporter signature motif; other site 941193008449 Walker B; other site 941193008450 D-loop; other site 941193008451 H-loop/switch region; other site 941193008452 TOBE domain; Region: TOBE_2; pfam08402 941193008453 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 941193008454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193008455 dimer interface [polypeptide binding]; other site 941193008456 conserved gate region; other site 941193008457 ABC-ATPase subunit interface; other site 941193008458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193008459 dimer interface [polypeptide binding]; other site 941193008460 conserved gate region; other site 941193008461 putative PBP binding loops; other site 941193008462 ABC-ATPase subunit interface; other site 941193008463 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 941193008464 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 941193008465 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 941193008466 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941193008467 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193008468 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 941193008469 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 941193008470 substrate binding site [chemical binding]; other site 941193008471 activation loop (A-loop); other site 941193008472 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 941193008473 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193008474 N-terminal plug; other site 941193008475 ligand-binding site [chemical binding]; other site 941193008476 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193008477 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193008478 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941193008479 dimerization interface [polypeptide binding]; other site 941193008480 Sulfatase; Region: Sulfatase; cl17466 941193008481 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 941193008482 Cupin; Region: Cupin_6; pfam12852 941193008483 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941193008484 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193008485 Uncharacterized conserved protein [Function unknown]; Region: COG2128 941193008486 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 941193008487 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193008488 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941193008489 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 941193008490 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 941193008491 Walker A/P-loop; other site 941193008492 ATP binding site [chemical binding]; other site 941193008493 Q-loop/lid; other site 941193008494 ABC transporter signature motif; other site 941193008495 Walker B; other site 941193008496 D-loop; other site 941193008497 H-loop/switch region; other site 941193008498 NMT1-like family; Region: NMT1_2; pfam13379 941193008499 NMT1/THI5 like; Region: NMT1; pfam09084 941193008500 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 941193008501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193008502 dimer interface [polypeptide binding]; other site 941193008503 conserved gate region; other site 941193008504 putative PBP binding loops; other site 941193008505 ABC-ATPase subunit interface; other site 941193008506 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 941193008507 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 941193008508 active site 941193008509 non-prolyl cis peptide bond; other site 941193008510 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 941193008511 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 941193008512 Flavin binding site [chemical binding]; other site 941193008513 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 941193008514 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 941193008515 Flavin binding site [chemical binding]; other site 941193008516 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 941193008517 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 941193008518 tetrameric interface [polypeptide binding]; other site 941193008519 activator binding site; other site 941193008520 NADP binding site [chemical binding]; other site 941193008521 substrate binding site [chemical binding]; other site 941193008522 catalytic residues [active] 941193008523 GntP family permease; Region: GntP_permease; pfam02447 941193008524 fructuronate transporter; Provisional; Region: PRK10034; cl15264 941193008525 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 941193008526 AAA domain; Region: AAA_33; pfam13671 941193008527 ATP-binding site [chemical binding]; other site 941193008528 Gluconate-6-phosphate binding site [chemical binding]; other site 941193008529 Transcriptional regulators [Transcription]; Region: PurR; COG1609 941193008530 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 941193008531 DNA binding site [nucleotide binding] 941193008532 domain linker motif; other site 941193008533 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 941193008534 putative ligand binding site [chemical binding]; other site 941193008535 putative dimerization interface [polypeptide binding]; other site 941193008536 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 941193008537 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 941193008538 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 941193008539 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193008540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193008541 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 941193008542 putative dimerization interface [polypeptide binding]; other site 941193008543 putative effector binding pocket; other site 941193008544 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 941193008545 Beta-lactamase; Region: Beta-lactamase; pfam00144 941193008546 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 941193008547 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941193008548 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 941193008549 non-specific DNA binding site [nucleotide binding]; other site 941193008550 salt bridge; other site 941193008551 sequence-specific DNA binding site [nucleotide binding]; other site 941193008552 Cupin domain; Region: Cupin_2; pfam07883 941193008553 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 941193008554 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 941193008555 active site 941193008556 iron coordination sites [ion binding]; other site 941193008557 substrate binding pocket [chemical binding]; other site 941193008558 NMT1-like family; Region: NMT1_2; pfam13379 941193008559 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 941193008560 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 941193008561 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 941193008562 Walker A/P-loop; other site 941193008563 ATP binding site [chemical binding]; other site 941193008564 Q-loop/lid; other site 941193008565 ABC transporter signature motif; other site 941193008566 Walker B; other site 941193008567 D-loop; other site 941193008568 H-loop/switch region; other site 941193008569 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 941193008570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193008571 putative PBP binding loops; other site 941193008572 ABC-ATPase subunit interface; other site 941193008573 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 941193008574 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 941193008575 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 941193008576 acyl-activating enzyme (AAE) consensus motif; other site 941193008577 AMP binding site [chemical binding]; other site 941193008578 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941193008579 Condensation domain; Region: Condensation; pfam00668 941193008580 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 941193008581 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 941193008582 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 941193008583 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 941193008584 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 941193008585 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 941193008586 acyl-activating enzyme (AAE) consensus motif; other site 941193008587 AMP binding site [chemical binding]; other site 941193008588 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 941193008589 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 941193008590 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941193008591 Condensation domain; Region: Condensation; pfam00668 941193008592 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 941193008593 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 941193008594 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 941193008595 putative deacylase active site [active] 941193008596 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 941193008597 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 941193008598 putative active site [active] 941193008599 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 941193008600 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 941193008601 Interdomain contacts; other site 941193008602 Cytokine receptor motif; other site 941193008603 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 941193008604 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 941193008605 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193008606 DNA-binding site [nucleotide binding]; DNA binding site 941193008607 UTRA domain; Region: UTRA; pfam07702 941193008608 putative oxidoreductase; Provisional; Region: PRK08275 941193008609 L-aspartate oxidase; Provisional; Region: PRK06175 941193008610 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 941193008611 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 941193008612 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 941193008613 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193008614 substrate binding pocket [chemical binding]; other site 941193008615 membrane-bound complex binding site; other site 941193008616 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 941193008617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 941193008618 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 941193008619 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 941193008620 Walker A/P-loop; other site 941193008621 ATP binding site [chemical binding]; other site 941193008622 Q-loop/lid; other site 941193008623 ABC transporter signature motif; other site 941193008624 Walker B; other site 941193008625 D-loop; other site 941193008626 H-loop/switch region; other site 941193008627 HEAT repeats; Region: HEAT_2; pfam13646 941193008628 HEAT repeats; Region: HEAT_2; pfam13646 941193008629 Protein of unknown function (DUF971); Region: DUF971; cl01414 941193008630 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 941193008631 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 941193008632 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 941193008633 Trp docking motif [polypeptide binding]; other site 941193008634 putative active site [active] 941193008635 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 941193008636 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193008637 N-terminal plug; other site 941193008638 ligand-binding site [chemical binding]; other site 941193008639 Peptidase family M48; Region: Peptidase_M48; cl12018 941193008640 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 941193008641 Peptidase family M48; Region: Peptidase_M48; cl12018 941193008642 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941193008643 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193008644 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 941193008645 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941193008646 Low molecular weight phosphatase family; Region: LMWPc; cd00115 941193008647 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 941193008648 active site 941193008649 arsenical pump membrane protein; Provisional; Region: PRK15445 941193008650 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 941193008651 transmembrane helices; other site 941193008652 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941193008653 dimerization interface [polypeptide binding]; other site 941193008654 putative DNA binding site [nucleotide binding]; other site 941193008655 putative Zn2+ binding site [ion binding]; other site 941193008656 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 941193008657 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941193008658 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193008659 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 941193008660 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 941193008661 putative NAD(P) binding site [chemical binding]; other site 941193008662 putative substrate binding site [chemical binding]; other site 941193008663 catalytic Zn binding site [ion binding]; other site 941193008664 structural Zn binding site [ion binding]; other site 941193008665 dimer interface [polypeptide binding]; other site 941193008666 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 941193008667 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 941193008668 DNA binding residues [nucleotide binding] 941193008669 dimer interface [polypeptide binding]; other site 941193008670 [2Fe-2S] cluster binding site [ion binding]; other site 941193008671 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 941193008672 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 941193008673 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 941193008674 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 941193008675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941193008676 Coenzyme A binding pocket [chemical binding]; other site 941193008677 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193008678 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193008679 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941193008680 hypothetical protein; Validated; Region: PRK06186 941193008681 conserved cys residue [active] 941193008682 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 941193008683 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193008684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193008685 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193008686 dimerization interface [polypeptide binding]; other site 941193008687 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 941193008688 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 941193008689 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 941193008690 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 941193008691 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 941193008692 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 941193008693 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 941193008694 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 941193008695 dimerization interface [polypeptide binding]; other site 941193008696 ligand binding site [chemical binding]; other site 941193008697 NADP binding site [chemical binding]; other site 941193008698 catalytic site [active] 941193008699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193008700 D-galactonate transporter; Region: 2A0114; TIGR00893 941193008701 putative substrate translocation pore; other site 941193008702 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 941193008703 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 941193008704 substrate binding site [chemical binding]; other site 941193008705 ATP binding site [chemical binding]; other site 941193008706 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 941193008707 Transcriptional regulators [Transcription]; Region: PurR; COG1609 941193008708 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 941193008709 DNA binding site [nucleotide binding] 941193008710 domain linker motif; other site 941193008711 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 941193008712 putative dimerization interface [polypeptide binding]; other site 941193008713 putative ligand binding site [chemical binding]; other site 941193008714 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193008715 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193008716 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941193008717 putative effector binding pocket; other site 941193008718 dimerization interface [polypeptide binding]; other site 941193008719 Cytochrome c553 [Energy production and conversion]; Region: COG2863 941193008720 Cytochrome c; Region: Cytochrom_C; cl11414 941193008721 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 941193008722 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 941193008723 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 941193008724 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 941193008725 substrate binding pocket [chemical binding]; other site 941193008726 active site 941193008727 iron coordination sites [ion binding]; other site 941193008728 Pyoverdine/dityrosine biosynthesis protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: DIT1; COG3207 941193008729 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 941193008730 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 941193008731 active site 941193008732 homodimer interface [polypeptide binding]; other site 941193008733 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 941193008734 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 941193008735 Helix-turn-helix domain; Region: HTH_19; pfam12844 941193008736 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 941193008737 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941193008738 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 941193008739 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 941193008740 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 941193008741 E3 interaction surface; other site 941193008742 lipoyl attachment site [posttranslational modification]; other site 941193008743 e3 binding domain; Region: E3_binding; pfam02817 941193008744 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 941193008745 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 941193008746 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 941193008747 alpha subunit interface [polypeptide binding]; other site 941193008748 TPP binding site [chemical binding]; other site 941193008749 heterodimer interface [polypeptide binding]; other site 941193008750 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 941193008751 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 941193008752 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 941193008753 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 941193008754 tetramer interface [polypeptide binding]; other site 941193008755 TPP-binding site [chemical binding]; other site 941193008756 heterodimer interface [polypeptide binding]; other site 941193008757 phosphorylation loop region [posttranslational modification] 941193008758 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941193008759 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941193008760 putative DNA binding site [nucleotide binding]; other site 941193008761 putative Zn2+ binding site [ion binding]; other site 941193008762 AsnC family; Region: AsnC_trans_reg; pfam01037 941193008763 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 941193008764 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 941193008765 active site 941193008766 DNA binding site [nucleotide binding] 941193008767 Int/Topo IB signature motif; other site 941193008768 catalytic residues [active] 941193008769 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 941193008770 Predicted oxidoreductase [General function prediction only]; Region: COG3573 941193008771 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 941193008772 Acyltransferase family; Region: Acyl_transf_3; pfam01757 941193008773 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 941193008774 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 941193008775 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941193008776 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 941193008777 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 941193008778 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 941193008779 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 941193008780 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941193008781 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 941193008782 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 941193008783 Chain length determinant protein; Region: Wzz; cl15801 941193008784 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941193008785 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 941193008786 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 941193008787 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 941193008788 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 941193008789 active site 941193008790 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 941193008791 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 941193008792 Substrate binding site; other site 941193008793 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 941193008794 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 941193008795 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 941193008796 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 941193008797 N-acetyl-D-glucosamine binding site [chemical binding]; other site 941193008798 catalytic residue [active] 941193008799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 941193008800 MOSC domain; Region: MOSC; pfam03473 941193008801 3-alpha domain; Region: 3-alpha; pfam03475 941193008802 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 941193008803 classical (c) SDRs; Region: SDR_c; cd05233 941193008804 NAD(P) binding site [chemical binding]; other site 941193008805 active site 941193008806 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 941193008807 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 941193008808 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193008809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193008810 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 941193008811 putative effector binding pocket; other site 941193008812 putative dimerization interface [polypeptide binding]; other site 941193008813 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 941193008814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193008815 putative substrate translocation pore; other site 941193008816 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 941193008817 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 941193008818 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 941193008819 dimer interface [polypeptide binding]; other site 941193008820 NADP binding site [chemical binding]; other site 941193008821 catalytic residues [active] 941193008822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 941193008823 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 941193008824 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 941193008825 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 941193008826 putative active site pocket [active] 941193008827 putative metal binding site [ion binding]; other site 941193008828 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 941193008829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193008830 putative substrate translocation pore; other site 941193008831 outer membrane porin, OprD family; Region: OprD; pfam03573 941193008832 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 941193008833 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 941193008834 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 941193008835 Amidohydrolase; Region: Amidohydro_2; pfam04909 941193008836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193008837 D-galactonate transporter; Region: 2A0114; TIGR00893 941193008838 putative substrate translocation pore; other site 941193008839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 941193008840 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 941193008841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 941193008842 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193008843 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193008844 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193008845 dimerization interface [polypeptide binding]; other site 941193008846 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941193008847 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193008848 substrate binding pocket [chemical binding]; other site 941193008849 membrane-bound complex binding site; other site 941193008850 hinge residues; other site 941193008851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193008852 dimer interface [polypeptide binding]; other site 941193008853 conserved gate region; other site 941193008854 putative PBP binding loops; other site 941193008855 ABC-ATPase subunit interface; other site 941193008856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193008857 dimer interface [polypeptide binding]; other site 941193008858 conserved gate region; other site 941193008859 putative PBP binding loops; other site 941193008860 ABC-ATPase subunit interface; other site 941193008861 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 941193008862 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 941193008863 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941193008864 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 941193008865 Uncharacterized conserved protein [Function unknown]; Region: COG1359 941193008866 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 941193008867 Prostaglandin dehydrogenases; Region: PGDH; cd05288 941193008868 NAD(P) binding site [chemical binding]; other site 941193008869 substrate binding site [chemical binding]; other site 941193008870 dimer interface [polypeptide binding]; other site 941193008871 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193008872 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193008873 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 941193008874 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 941193008875 hydroxyglutarate oxidase; Provisional; Region: PRK11728 941193008876 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 941193008877 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941193008878 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 941193008879 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941193008880 catalytic loop [active] 941193008881 iron binding site [ion binding]; other site 941193008882 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 941193008883 FOG: CBS domain [General function prediction only]; Region: COG0517 941193008884 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 941193008885 Anthrax toxin LF subunit; Region: Anthrax_toxA; pfam03497 941193008886 General stress protein [General function prediction only]; Region: GsiB; COG3729 941193008887 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 941193008888 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 941193008889 active site 941193008890 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 941193008891 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 941193008892 NAD binding site [chemical binding]; other site 941193008893 catalytic Zn binding site [ion binding]; other site 941193008894 structural Zn binding site [ion binding]; other site 941193008895 Low affinity iron permease; Region: Iron_permease; pfam04120 941193008896 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 941193008897 dimanganese center [ion binding]; other site 941193008898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 941193008899 Predicted membrane protein [Function unknown]; Region: COG3205 941193008900 carboxylate-amine ligase; Provisional; Region: PRK13515 941193008901 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 941193008902 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 941193008903 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193008904 S-adenosylmethionine binding site [chemical binding]; other site 941193008905 Yip1 domain; Region: Yip1; cl17815 941193008906 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193008907 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 941193008908 putative active site [active] 941193008909 heme pocket [chemical binding]; other site 941193008910 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 941193008911 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193008912 putative active site [active] 941193008913 heme pocket [chemical binding]; other site 941193008914 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193008915 dimer interface [polypeptide binding]; other site 941193008916 phosphorylation site [posttranslational modification] 941193008917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193008918 ATP binding site [chemical binding]; other site 941193008919 Mg2+ binding site [ion binding]; other site 941193008920 G-X-G motif; other site 941193008921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193008922 active site 941193008923 phosphorylation site [posttranslational modification] 941193008924 intermolecular recognition site; other site 941193008925 dimerization interface [polypeptide binding]; other site 941193008926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193008927 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 941193008928 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 941193008929 metal binding site [ion binding]; metal-binding site 941193008930 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 941193008931 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 941193008932 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 941193008933 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 941193008934 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 941193008935 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 941193008936 glycogen synthase; Provisional; Region: glgA; PRK00654 941193008937 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 941193008938 ADP-binding pocket [chemical binding]; other site 941193008939 homodimer interface [polypeptide binding]; other site 941193008940 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 941193008941 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 941193008942 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 941193008943 catalytic site [active] 941193008944 active site 941193008945 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 941193008946 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 941193008947 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 941193008948 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 941193008949 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 941193008950 active site 941193008951 catalytic site [active] 941193008952 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 941193008953 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 941193008954 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 941193008955 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 941193008956 active site 941193008957 catalytic site [active] 941193008958 FOG: CBS domain [General function prediction only]; Region: COG0517 941193008959 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 941193008960 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 941193008961 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 941193008962 NAD binding site [chemical binding]; other site 941193008963 catalytic Zn binding site [ion binding]; other site 941193008964 structural Zn binding site [ion binding]; other site 941193008965 Protein of unknown function DUF72; Region: DUF72; pfam01904 941193008966 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 941193008967 putative catalytic site [active] 941193008968 putative metal binding site [ion binding]; other site 941193008969 putative phosphate binding site [ion binding]; other site 941193008970 cardiolipin synthase 2; Provisional; Region: PRK11263 941193008971 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 941193008972 putative active site [active] 941193008973 catalytic site [active] 941193008974 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 941193008975 putative active site [active] 941193008976 catalytic site [active] 941193008977 Predicted integral membrane protein [Function unknown]; Region: COG0392 941193008978 glycogen branching enzyme; Provisional; Region: PRK05402 941193008979 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 941193008980 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 941193008981 active site 941193008982 catalytic site [active] 941193008983 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 941193008984 trehalose synthase; Region: treS_nterm; TIGR02456 941193008985 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 941193008986 active site 941193008987 catalytic site [active] 941193008988 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 941193008989 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 941193008990 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 941193008991 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 941193008992 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 941193008993 active site 941193008994 homodimer interface [polypeptide binding]; other site 941193008995 catalytic site [active] 941193008996 acceptor binding site [chemical binding]; other site 941193008997 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 941193008998 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 941193008999 putative DNA binding site [nucleotide binding]; other site 941193009000 putative homodimer interface [polypeptide binding]; other site 941193009001 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 941193009002 MgtC family; Region: MgtC; pfam02308 941193009003 hydroperoxidase II; Provisional; Region: katE; PRK11249 941193009004 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 941193009005 tetramer interface [polypeptide binding]; other site 941193009006 heme binding pocket [chemical binding]; other site 941193009007 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 941193009008 domain interactions; other site 941193009009 General stress protein [General function prediction only]; Region: GsiB; COG3729 941193009010 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 941193009011 homodimer interface [polypeptide binding]; other site 941193009012 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 941193009013 active site pocket [active] 941193009014 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 941193009015 short chain dehydrogenase; Provisional; Region: PRK06701 941193009016 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 941193009017 NAD binding site [chemical binding]; other site 941193009018 metal binding site [ion binding]; metal-binding site 941193009019 active site 941193009020 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 941193009021 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 941193009022 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 941193009023 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 941193009024 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 941193009025 active site 941193009026 DNA binding site [nucleotide binding] 941193009027 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 941193009028 DNA binding site [nucleotide binding] 941193009029 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 941193009030 nucleotide binding site [chemical binding]; other site 941193009031 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 941193009032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 941193009033 active site 941193009034 phosphorylation site [posttranslational modification] 941193009035 intermolecular recognition site; other site 941193009036 dimerization interface [polypeptide binding]; other site 941193009037 Predicted membrane protein [Function unknown]; Region: COG2323 941193009038 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 941193009039 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 941193009040 Predicted outer membrane protein [Function unknown]; Region: COG3652 941193009041 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941193009042 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 941193009043 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 941193009044 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 941193009045 Fimbrial protein; Region: Fimbrial; cl01416 941193009046 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 941193009047 PapC N-terminal domain; Region: PapC_N; pfam13954 941193009048 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 941193009049 PapC C-terminal domain; Region: PapC_C; pfam13953 941193009050 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 941193009051 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 941193009052 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 941193009053 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 941193009054 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 941193009055 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 941193009056 Active Sites [active] 941193009057 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 941193009058 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 941193009059 ParB-like nuclease domain; Region: ParBc; pfam02195 941193009060 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 941193009061 Pseudomonas putida aldehyde dehydrogenase PsfA (ACA09737)-like; Region: ALDH_PsfA-ACA09737; cd07120 941193009062 NAD(P) binding site [chemical binding]; other site 941193009063 catalytic residues [active] 941193009064 choline dehydrogenase; Validated; Region: PRK02106 941193009065 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941193009066 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 941193009067 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193009068 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193009069 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941193009070 putative effector binding pocket; other site 941193009071 dimerization interface [polypeptide binding]; other site 941193009072 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 941193009073 hydrophobic ligand binding site; other site 941193009074 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 941193009075 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193009076 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 941193009077 substrate binding pocket [chemical binding]; other site 941193009078 dimerization interface [polypeptide binding]; other site 941193009079 SnoaL-like domain; Region: SnoaL_2; pfam12680 941193009080 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 941193009081 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 941193009082 tetramer interface [polypeptide binding]; other site 941193009083 catalytic Zn binding site [ion binding]; other site 941193009084 NADP binding site [chemical binding]; other site 941193009085 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 941193009086 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 941193009087 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 941193009088 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193009089 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 941193009090 DNA binding site [nucleotide binding] 941193009091 active site 941193009092 Uncharacterized conserved protein [Function unknown]; Region: COG4336 941193009093 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193009094 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193009095 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941193009096 dimerization interface [polypeptide binding]; other site 941193009097 benzoate transport; Region: 2A0115; TIGR00895 941193009098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193009099 putative substrate translocation pore; other site 941193009100 outer membrane porin, OprD family; Region: OprD; pfam03573 941193009101 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 941193009102 putative active site [active] 941193009103 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 941193009104 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 941193009105 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 941193009106 Predicted outer membrane protein [Function unknown]; Region: COG3652 941193009107 thiamine pyrophosphate protein; Provisional; Region: PRK08273 941193009108 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 941193009109 PYR/PP interface [polypeptide binding]; other site 941193009110 dimer interface [polypeptide binding]; other site 941193009111 tetramer interface [polypeptide binding]; other site 941193009112 TPP binding site [chemical binding]; other site 941193009113 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 941193009114 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 941193009115 TPP-binding site [chemical binding]; other site 941193009116 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 941193009117 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 941193009118 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 941193009119 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 941193009120 trimer interface [polypeptide binding]; other site 941193009121 active site 941193009122 substrate binding site [chemical binding]; other site 941193009123 CoA binding site [chemical binding]; other site 941193009124 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 941193009125 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 941193009126 dimer interface [polypeptide binding]; other site 941193009127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193009128 catalytic residue [active] 941193009129 Ubiquitin-like proteins; Region: UBQ; cl00155 941193009130 charged pocket; other site 941193009131 hydrophobic patch; other site 941193009132 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 941193009133 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 941193009134 ATP binding site [chemical binding]; other site 941193009135 substrate interface [chemical binding]; other site 941193009136 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 941193009137 active site residue [active] 941193009138 Predicted metal-dependent protease of the PAD1/JAB1 superfamily [General function prediction only]; Region: COG1310 941193009139 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 941193009140 EamA-like transporter family; Region: EamA; pfam00892 941193009141 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 941193009142 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193009143 DNA-binding site [nucleotide binding]; DNA binding site 941193009144 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941193009145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193009146 homodimer interface [polypeptide binding]; other site 941193009147 catalytic residue [active] 941193009148 short chain dehydrogenase; Provisional; Region: PRK08267 941193009149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193009150 NAD(P) binding site [chemical binding]; other site 941193009151 active site 941193009152 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 941193009153 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 941193009154 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 941193009155 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 941193009156 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941193009157 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193009158 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 941193009159 FecR protein; Region: FecR; pfam04773 941193009160 RNA polymerase sigma factor; Provisional; Region: PRK12525 941193009161 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941193009162 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941193009163 DNA binding residues [nucleotide binding] 941193009164 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 941193009165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 941193009166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193009167 putative substrate translocation pore; other site 941193009168 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941193009169 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 941193009170 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 941193009171 dimer interface [polypeptide binding]; other site 941193009172 active site 941193009173 non-prolyl cis peptide bond; other site 941193009174 insertion regions; other site 941193009175 Secretin and TonB N terminus short domain; Region: STN; smart00965 941193009176 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 941193009177 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193009178 N-terminal plug; other site 941193009179 ligand-binding site [chemical binding]; other site 941193009180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 941193009181 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 941193009182 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 941193009183 inter-subunit interface; other site 941193009184 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 941193009185 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 941193009186 active site 941193009187 dimer interface [polypeptide binding]; other site 941193009188 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 941193009189 Ligand Binding Site [chemical binding]; other site 941193009190 Molecular Tunnel; other site 941193009191 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 941193009192 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 941193009193 [2Fe-2S] cluster binding site [ion binding]; other site 941193009194 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 941193009195 putative alpha subunit interface [polypeptide binding]; other site 941193009196 putative active site [active] 941193009197 putative substrate binding site [chemical binding]; other site 941193009198 Fe binding site [ion binding]; other site 941193009199 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941193009200 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941193009201 putative DNA binding site [nucleotide binding]; other site 941193009202 putative Zn2+ binding site [ion binding]; other site 941193009203 AsnC family; Region: AsnC_trans_reg; pfam01037 941193009204 arylformamidase; Region: trp_arylform; TIGR03035 941193009205 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 941193009206 kynureninase; Region: kynureninase; TIGR01814 941193009207 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941193009208 catalytic residue [active] 941193009209 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 941193009210 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 941193009211 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193009212 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193009213 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193009214 dimerization interface [polypeptide binding]; other site 941193009215 Predicted amidohydrolase [General function prediction only]; Region: COG0388 941193009216 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580 941193009217 putative active site [active] 941193009218 catalytic triad [active] 941193009219 putative dimer interface [polypeptide binding]; other site 941193009220 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 941193009221 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 941193009222 Na binding site [ion binding]; other site 941193009223 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322 941193009224 PAS domain S-box; Region: sensory_box; TIGR00229 941193009225 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193009226 putative active site [active] 941193009227 heme pocket [chemical binding]; other site 941193009228 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193009229 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193009230 metal binding site [ion binding]; metal-binding site 941193009231 active site 941193009232 I-site; other site 941193009233 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941193009234 elongation factor G; Reviewed; Region: PRK00007 941193009235 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 941193009236 G1 box; other site 941193009237 putative GEF interaction site [polypeptide binding]; other site 941193009238 GTP/Mg2+ binding site [chemical binding]; other site 941193009239 Switch I region; other site 941193009240 G2 box; other site 941193009241 G3 box; other site 941193009242 Switch II region; other site 941193009243 G4 box; other site 941193009244 G5 box; other site 941193009245 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 941193009246 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 941193009247 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 941193009248 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 941193009249 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193009250 N-terminal plug; other site 941193009251 ligand-binding site [chemical binding]; other site 941193009252 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 941193009253 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 941193009254 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 941193009255 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 941193009256 MFS_1 like family; Region: MFS_1_like; pfam12832 941193009257 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 941193009258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941193009259 motif II; other site 941193009260 Uncharacterized conserved protein [Function unknown]; Region: COG1434 941193009261 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 941193009262 putative active site [active] 941193009263 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 941193009264 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 941193009265 Multicopper oxidase; Region: Cu-oxidase; pfam00394 941193009266 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 941193009267 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 941193009268 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: PcoB; COG3667 941193009269 Uncharacterized conserved protein [Function unknown]; Region: COG3673 941193009270 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941193009271 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 941193009272 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941193009273 catalytic residue [active] 941193009274 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 941193009275 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941193009276 Walker A/P-loop; other site 941193009277 ATP binding site [chemical binding]; other site 941193009278 Q-loop/lid; other site 941193009279 ABC transporter signature motif; other site 941193009280 Walker B; other site 941193009281 D-loop; other site 941193009282 H-loop/switch region; other site 941193009283 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 941193009284 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941193009285 Walker A/P-loop; other site 941193009286 ATP binding site [chemical binding]; other site 941193009287 Q-loop/lid; other site 941193009288 ABC transporter signature motif; other site 941193009289 Walker B; other site 941193009290 D-loop; other site 941193009291 H-loop/switch region; other site 941193009292 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 941193009293 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 941193009294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193009295 dimer interface [polypeptide binding]; other site 941193009296 conserved gate region; other site 941193009297 ABC-ATPase subunit interface; other site 941193009298 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 941193009299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193009300 dimer interface [polypeptide binding]; other site 941193009301 conserved gate region; other site 941193009302 ABC-ATPase subunit interface; other site 941193009303 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 941193009304 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 941193009305 Secretin and TonB N terminus short domain; Region: STN; smart00965 941193009306 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193009307 N-terminal plug; other site 941193009308 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 941193009309 ligand-binding site [chemical binding]; other site 941193009310 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193009311 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193009312 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941193009313 putative effector binding pocket; other site 941193009314 dimerization interface [polypeptide binding]; other site 941193009315 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 941193009316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193009317 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 941193009318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193009319 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 941193009320 dimerization interface [polypeptide binding]; other site 941193009321 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 941193009322 active site clefts [active] 941193009323 zinc binding site [ion binding]; other site 941193009324 dimer interface [polypeptide binding]; other site 941193009325 cyanate hydratase; Validated; Region: PRK02866 941193009326 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 941193009327 oligomer interface [polypeptide binding]; other site 941193009328 active site 941193009329 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 941193009330 FecR protein; Region: FecR; pfam04773 941193009331 RNA polymerase sigma factor; Provisional; Region: PRK12525 941193009332 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941193009333 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941193009334 DNA binding residues [nucleotide binding] 941193009335 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 941193009336 metal binding site [ion binding]; metal-binding site 941193009337 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 941193009338 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 941193009339 Uncharacterized conserved protein [Function unknown]; Region: COG1359 941193009340 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 941193009341 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941193009342 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193009343 Haemolytic domain; Region: Haemolytic; pfam01809 941193009344 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 941193009345 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 941193009346 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 941193009347 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 941193009348 probable active site [active] 941193009349 serine/threonine transporter SstT; Provisional; Region: PRK13628 941193009350 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 941193009351 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 941193009352 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 941193009353 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 941193009354 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 941193009355 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 941193009356 Predicted membrane protein [Function unknown]; Region: COG4392 941193009357 Methyltransferase domain; Region: Methyltransf_23; pfam13489 941193009358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 941193009359 thiamine pyrophosphate protein; Validated; Region: PRK08199 941193009360 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 941193009361 PYR/PP interface [polypeptide binding]; other site 941193009362 dimer interface [polypeptide binding]; other site 941193009363 TPP binding site [chemical binding]; other site 941193009364 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 941193009365 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 941193009366 TPP-binding site [chemical binding]; other site 941193009367 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 941193009368 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 941193009369 FAD binding pocket [chemical binding]; other site 941193009370 FAD binding motif [chemical binding]; other site 941193009371 phosphate binding motif [ion binding]; other site 941193009372 NAD binding pocket [chemical binding]; other site 941193009373 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 941193009374 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193009375 DNA-binding site [nucleotide binding]; DNA binding site 941193009376 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941193009377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193009378 homodimer interface [polypeptide binding]; other site 941193009379 catalytic residue [active] 941193009380 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547 941193009381 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941193009382 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941193009383 putative DNA binding site [nucleotide binding]; other site 941193009384 putative Zn2+ binding site [ion binding]; other site 941193009385 AsnC family; Region: AsnC_trans_reg; pfam01037 941193009386 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 941193009387 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 941193009388 glutathione reductase; Validated; Region: PRK06116 941193009389 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941193009390 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941193009391 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 941193009392 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941193009393 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 941193009394 active site 941193009395 metal binding site [ion binding]; metal-binding site 941193009396 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 941193009397 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 941193009398 active site 941193009399 tetramer interface; other site 941193009400 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 941193009401 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 941193009402 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 941193009403 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 941193009404 Protein of unknown function (DUF3203); Region: DUF3203; pfam11462 941193009405 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193009406 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193009407 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 941193009408 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193009409 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193009410 multidrug efflux protein; Reviewed; Region: PRK09577 941193009411 Protein export membrane protein; Region: SecD_SecF; cl14618 941193009412 SdiA-regulated; Region: SdiA-regulated; pfam06977 941193009413 SdiA-regulated; Region: SdiA-regulated; cd09971 941193009414 putative active site [active] 941193009415 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 941193009416 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 941193009417 DNA binding residues [nucleotide binding] 941193009418 putative dimer interface [polypeptide binding]; other site 941193009419 isovaleryl-CoA dehydrogenase; Region: PLN02519 941193009420 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 941193009421 substrate binding site [chemical binding]; other site 941193009422 FAD binding site [chemical binding]; other site 941193009423 catalytic base [active] 941193009424 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 941193009425 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 941193009426 gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674 941193009427 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941193009428 substrate binding site [chemical binding]; other site 941193009429 oxyanion hole (OAH) forming residues; other site 941193009430 trimer interface [polypeptide binding]; other site 941193009431 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 941193009432 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 941193009433 ATP-grasp domain; Region: ATP-grasp_4; cl17255 941193009434 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 941193009435 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 941193009436 carboxyltransferase (CT) interaction site; other site 941193009437 biotinylation site [posttranslational modification]; other site 941193009438 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 941193009439 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 941193009440 active site 941193009441 catalytic residues [active] 941193009442 metal binding site [ion binding]; metal-binding site 941193009443 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 941193009444 Transcriptional regulator [Transcription]; Region: IclR; COG1414 941193009445 Bacterial transcriptional regulator; Region: IclR; pfam01614 941193009446 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 941193009447 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 941193009448 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 941193009449 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 941193009450 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 941193009451 C-terminal domain interface [polypeptide binding]; other site 941193009452 GSH binding site (G-site) [chemical binding]; other site 941193009453 maleylacetoacetate isomerase; Region: maiA; TIGR01262 941193009454 putative dimer interface [polypeptide binding]; other site 941193009455 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 941193009456 dimer interface [polypeptide binding]; other site 941193009457 N-terminal domain interface [polypeptide binding]; other site 941193009458 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 941193009459 benzoate transport; Region: 2A0115; TIGR00895 941193009460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193009461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193009462 PAS domain; Region: PAS; smart00091 941193009463 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 941193009464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193009465 Walker B motif; other site 941193009466 arginine finger; other site 941193009467 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941193009468 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 941193009469 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 941193009470 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 941193009471 NAD binding site [chemical binding]; other site 941193009472 homotetramer interface [polypeptide binding]; other site 941193009473 homodimer interface [polypeptide binding]; other site 941193009474 substrate binding site [chemical binding]; other site 941193009475 active site 941193009476 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 941193009477 acetyl-CoA acetyltransferase; Provisional; Region: PRK05656 941193009478 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 941193009479 dimer interface [polypeptide binding]; other site 941193009480 active site 941193009481 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 941193009482 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 941193009483 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193009484 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193009485 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 941193009486 putative dimerization interface [polypeptide binding]; other site 941193009487 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 941193009488 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 941193009489 acyl-activating enzyme (AAE) consensus motif; other site 941193009490 putative AMP binding site [chemical binding]; other site 941193009491 putative active site [active] 941193009492 putative CoA binding site [chemical binding]; other site 941193009493 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 941193009494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 941193009495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 941193009496 major facilitator superfamily transporter; Provisional; Region: PRK05122 941193009497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193009498 putative substrate translocation pore; other site 941193009499 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 941193009500 PAS domain S-box; Region: sensory_box; TIGR00229 941193009501 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 941193009502 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193009503 dimer interface [polypeptide binding]; other site 941193009504 phosphorylation site [posttranslational modification] 941193009505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193009506 ATP binding site [chemical binding]; other site 941193009507 G-X-G motif; other site 941193009508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193009509 active site 941193009510 phosphorylation site [posttranslational modification] 941193009511 intermolecular recognition site; other site 941193009512 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 941193009513 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 941193009514 putative active site [active] 941193009515 metal binding site [ion binding]; metal-binding site 941193009516 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 941193009517 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 941193009518 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 941193009519 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941193009520 FeS/SAM binding site; other site 941193009521 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 941193009522 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 941193009523 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 941193009524 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 941193009525 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 941193009526 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 941193009527 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 941193009528 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 941193009529 NAD(P) binding site [chemical binding]; other site 941193009530 catalytic residues [active] 941193009531 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 941193009532 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 941193009533 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 941193009534 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 941193009535 dimer interface [polypeptide binding]; other site 941193009536 Trp docking motif [polypeptide binding]; other site 941193009537 active site 941193009538 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 941193009539 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 941193009540 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 941193009541 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 941193009542 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 941193009543 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 941193009544 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941193009545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193009546 active site 941193009547 phosphorylation site [posttranslational modification] 941193009548 intermolecular recognition site; other site 941193009549 dimerization interface [polypeptide binding]; other site 941193009550 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193009551 DNA binding residues [nucleotide binding] 941193009552 dimerization interface [polypeptide binding]; other site 941193009553 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 941193009554 Histidine kinase; Region: HisKA_3; pfam07730 941193009555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193009556 ATP binding site [chemical binding]; other site 941193009557 Mg2+ binding site [ion binding]; other site 941193009558 G-X-G motif; other site 941193009559 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941193009560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193009561 active site 941193009562 phosphorylation site [posttranslational modification] 941193009563 intermolecular recognition site; other site 941193009564 dimerization interface [polypeptide binding]; other site 941193009565 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193009566 DNA binding residues [nucleotide binding] 941193009567 dimerization interface [polypeptide binding]; other site 941193009568 PAS fold; Region: PAS_7; pfam12860 941193009569 PAS fold; Region: PAS_7; pfam12860 941193009570 PAS fold; Region: PAS_4; pfam08448 941193009571 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941193009572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193009573 dimer interface [polypeptide binding]; other site 941193009574 phosphorylation site [posttranslational modification] 941193009575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193009576 ATP binding site [chemical binding]; other site 941193009577 Mg2+ binding site [ion binding]; other site 941193009578 G-X-G motif; other site 941193009579 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 941193009580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193009581 active site 941193009582 phosphorylation site [posttranslational modification] 941193009583 intermolecular recognition site; other site 941193009584 dimerization interface [polypeptide binding]; other site 941193009585 Uncharacterized conserved protein [Function unknown]; Region: COG3287 941193009586 FIST N domain; Region: FIST; pfam08495 941193009587 FIST C domain; Region: FIST_C; pfam10442 941193009588 Gram-negative porin; Region: Porin_4; pfam13609 941193009589 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 941193009590 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 941193009591 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 941193009592 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 941193009593 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 941193009594 Sulfatase; Region: Sulfatase; pfam00884 941193009595 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 941193009596 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 941193009597 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 941193009598 putative substrate binding pocket [chemical binding]; other site 941193009599 trimer interface [polypeptide binding]; other site 941193009600 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 941193009601 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193009602 Walker A/P-loop; other site 941193009603 ATP binding site [chemical binding]; other site 941193009604 Q-loop/lid; other site 941193009605 ABC transporter signature motif; other site 941193009606 Walker B; other site 941193009607 D-loop; other site 941193009608 H-loop/switch region; other site 941193009609 ABC transporter; Region: ABC_tran_2; pfam12848 941193009610 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941193009611 azoreductase; Reviewed; Region: PRK00170 941193009612 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941193009613 LysR family transcriptional regulator; Provisional; Region: PRK14997 941193009614 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193009615 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193009616 dimerization interface [polypeptide binding]; other site 941193009617 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 941193009618 DNA-binding site [nucleotide binding]; DNA binding site 941193009619 RNA-binding motif; other site 941193009620 Predicted membrane protein [Function unknown]; Region: COG3326 941193009621 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 941193009622 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 941193009623 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 941193009624 AAA domain; Region: AAA_28; pfam13521 941193009625 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 941193009626 putative active site [active] 941193009627 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 941193009628 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 941193009629 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 941193009630 substrate binding site [chemical binding]; other site 941193009631 dimer interface [polypeptide binding]; other site 941193009632 ATP binding site [chemical binding]; other site 941193009633 Transcriptional regulators [Transcription]; Region: PurR; COG1609 941193009634 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 941193009635 DNA binding site [nucleotide binding] 941193009636 domain linker motif; other site 941193009637 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 941193009638 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941193009639 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 941193009640 TM-ABC transporter signature motif; other site 941193009641 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 941193009642 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 941193009643 Walker A/P-loop; other site 941193009644 ATP binding site [chemical binding]; other site 941193009645 Q-loop/lid; other site 941193009646 ABC transporter signature motif; other site 941193009647 Walker B; other site 941193009648 D-loop; other site 941193009649 H-loop/switch region; other site 941193009650 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 941193009651 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 941193009652 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 941193009653 ligand binding site [chemical binding]; other site 941193009654 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 941193009655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193009656 Walker A motif; other site 941193009657 ATP binding site [chemical binding]; other site 941193009658 Walker B motif; other site 941193009659 arginine finger; other site 941193009660 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941193009661 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 941193009662 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 941193009663 ATP-grasp domain; Region: ATP-grasp_4; cl17255 941193009664 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 941193009665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941193009666 Coenzyme A binding pocket [chemical binding]; other site 941193009667 Peptidase_C39 like family; Region: DUF3335; pfam11814 941193009668 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 941193009669 putative heme binding pocket [chemical binding]; other site 941193009670 Domain of unknown function (DUF4354); Region: DUF4354; pfam14263 941193009671 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 941193009672 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 941193009673 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 941193009674 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 941193009675 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 941193009676 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 941193009677 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 941193009678 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 941193009679 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193009680 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 941193009681 putative active site [active] 941193009682 heme pocket [chemical binding]; other site 941193009683 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193009684 putative active site [active] 941193009685 heme pocket [chemical binding]; other site 941193009686 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 941193009687 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193009688 dimer interface [polypeptide binding]; other site 941193009689 putative CheW interface [polypeptide binding]; other site 941193009690 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 941193009691 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 941193009692 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 941193009693 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 941193009694 THF binding site; other site 941193009695 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 941193009696 substrate binding site [chemical binding]; other site 941193009697 THF binding site; other site 941193009698 zinc-binding site [ion binding]; other site 941193009699 YcaO domain protein; Region: TIGR03549 941193009700 OsmC-like protein; Region: OsmC; pfam02566 941193009701 YcaO-like family; Region: YcaO; pfam02624 941193009702 Uncharacterized conserved protein [Function unknown]; Region: COG4744 941193009703 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 941193009704 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 941193009705 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 941193009706 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 941193009707 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 941193009708 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193009709 N-terminal plug; other site 941193009710 ligand-binding site [chemical binding]; other site 941193009711 Methyltransferase domain; Region: Methyltransf_31; pfam13847 941193009712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193009713 S-adenosylmethionine binding site [chemical binding]; other site 941193009714 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 941193009715 ATP cone domain; Region: ATP-cone; pfam03477 941193009716 Class III ribonucleotide reductase; Region: RNR_III; cd01675 941193009717 effector binding site; other site 941193009718 active site 941193009719 Zn binding site [ion binding]; other site 941193009720 glycine loop; other site 941193009721 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 941193009722 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 941193009723 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941193009724 FeS/SAM binding site; other site 941193009725 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 941193009726 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 941193009727 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 941193009728 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 941193009729 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 941193009730 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 941193009731 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 941193009732 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 941193009733 RNA polymerase sigma factor; Provisional; Region: PRK12528 941193009734 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941193009735 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941193009736 DNA binding residues [nucleotide binding] 941193009737 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 941193009738 FecR protein; Region: FecR; pfam04773 941193009739 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 941193009740 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193009741 N-terminal plug; other site 941193009742 ligand-binding site [chemical binding]; other site 941193009743 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 941193009744 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 941193009745 RNA polymerase Rpb5, C-terminal domain; Region: RNA_pol_Rpb5_C; cl00883 941193009746 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 941193009747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193009748 putative substrate translocation pore; other site 941193009749 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941193009750 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 941193009751 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 941193009752 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 941193009753 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 941193009754 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 941193009755 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 941193009756 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 941193009757 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 941193009758 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 941193009759 Glutamine amidotransferase class-I; Region: GATase; pfam00117 941193009760 glutamine binding [chemical binding]; other site 941193009761 catalytic triad [active] 941193009762 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 941193009763 Isochorismatase family; Region: Isochorismatase; pfam00857 941193009764 catalytic triad [active] 941193009765 conserved cis-peptide bond; other site 941193009766 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 941193009767 Phenazine biosynthesis protein A/B; Region: PHZA_PHZB; pfam03284 941193009768 Phenazine biosynthesis protein A/B; Region: PHZA_PHZB; pfam03284 941193009769 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 941193009770 Autoinducer binding domain; Region: Autoind_bind; pfam03472 941193009771 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193009772 DNA binding residues [nucleotide binding] 941193009773 dimerization interface [polypeptide binding]; other site 941193009774 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 941193009775 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 941193009776 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 941193009777 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 941193009778 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 941193009779 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 941193009780 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 941193009781 active site 941193009782 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 941193009783 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 941193009784 putative C-terminal domain interface [polypeptide binding]; other site 941193009785 putative GSH binding site (G-site) [chemical binding]; other site 941193009786 putative dimer interface [polypeptide binding]; other site 941193009787 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 941193009788 putative N-terminal domain interface [polypeptide binding]; other site 941193009789 putative dimer interface [polypeptide binding]; other site 941193009790 putative substrate binding pocket (H-site) [chemical binding]; other site 941193009791 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 941193009792 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 941193009793 dimer interface [polypeptide binding]; other site 941193009794 active site 941193009795 catalytic residue [active] 941193009796 DNA polymerase II; Reviewed; Region: PRK05762 941193009797 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 941193009798 active site 941193009799 catalytic site [active] 941193009800 substrate binding site [chemical binding]; other site 941193009801 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 941193009802 active site 941193009803 metal-binding site 941193009804 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941193009805 Coenzyme A binding pocket [chemical binding]; other site 941193009806 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 941193009807 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941193009808 sequence-specific DNA binding site [nucleotide binding]; other site 941193009809 salt bridge; other site 941193009810 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 941193009811 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 941193009812 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 941193009813 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941193009814 catalytic loop [active] 941193009815 iron binding site [ion binding]; other site 941193009816 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 941193009817 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 941193009818 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 941193009819 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 941193009820 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 941193009821 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 941193009822 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941193009823 non-specific DNA binding site [nucleotide binding]; other site 941193009824 salt bridge; other site 941193009825 sequence-specific DNA binding site [nucleotide binding]; other site 941193009826 HD domain; Region: HD_3; pfam13023 941193009827 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 941193009828 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193009829 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193009830 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 941193009831 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 941193009832 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941193009833 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193009834 Walker A/P-loop; other site 941193009835 ATP binding site [chemical binding]; other site 941193009836 Q-loop/lid; other site 941193009837 ABC transporter signature motif; other site 941193009838 Walker B; other site 941193009839 D-loop; other site 941193009840 H-loop/switch region; other site 941193009841 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 941193009842 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 941193009843 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 941193009844 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 941193009845 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 941193009846 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 941193009847 Cl binding site [ion binding]; other site 941193009848 oligomer interface [polypeptide binding]; other site 941193009849 EcsC protein family; Region: EcsC; pfam12787 941193009850 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 941193009851 Peptidase family M23; Region: Peptidase_M23; pfam01551 941193009852 acyl carrier protein; Provisional; Region: acpP; PRK00982 941193009853 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 941193009854 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 941193009855 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 941193009856 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 941193009857 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 941193009858 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 941193009859 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 941193009860 DEAD_2; Region: DEAD_2; pfam06733 941193009861 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 941193009862 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 941193009863 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 941193009864 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193009865 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 941193009866 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 941193009867 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941193009868 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 941193009869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193009870 dimer interface [polypeptide binding]; other site 941193009871 conserved gate region; other site 941193009872 putative PBP binding loops; other site 941193009873 ABC-ATPase subunit interface; other site 941193009874 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 941193009875 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193009876 Walker A/P-loop; other site 941193009877 ATP binding site [chemical binding]; other site 941193009878 Q-loop/lid; other site 941193009879 ABC transporter signature motif; other site 941193009880 Walker B; other site 941193009881 D-loop; other site 941193009882 H-loop/switch region; other site 941193009883 TOBE domain; Region: TOBE; cl01440 941193009884 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 941193009885 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 941193009886 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193009887 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193009888 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 941193009889 putative effector binding pocket; other site 941193009890 dimerization interface [polypeptide binding]; other site 941193009891 Streptomycin 6-kinase [Defense mechanisms]; Region: StrB; COG3570 941193009892 Protein of unknown function (DUF808); Region: DUF808; pfam05661 941193009893 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 941193009894 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 941193009895 Low-spin heme binding site [chemical binding]; other site 941193009896 Putative water exit pathway; other site 941193009897 Binuclear center (active site) [active] 941193009898 Putative proton exit pathway; other site 941193009899 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 941193009900 HPP family; Region: HPP; pfam04982 941193009901 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 941193009902 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193009903 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193009904 LysR substrate binding domain; Region: LysR_substrate; pfam03466 941193009905 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193009906 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193009907 metal binding site [ion binding]; metal-binding site 941193009908 active site 941193009909 I-site; other site 941193009910 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 941193009911 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 941193009912 conserved cys residue [active] 941193009913 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193009914 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193009915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 941193009916 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 941193009917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193009918 putative substrate translocation pore; other site 941193009919 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 941193009920 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 941193009921 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 941193009922 Cytochrome c; Region: Cytochrom_C; cl11414 941193009923 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 941193009924 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 941193009925 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 941193009926 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 941193009927 substrate binding pocket [chemical binding]; other site 941193009928 dimer interface [polypeptide binding]; other site 941193009929 inhibitor binding site; inhibition site 941193009930 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 941193009931 B12 binding site [chemical binding]; other site 941193009932 cobalt ligand [ion binding]; other site 941193009933 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 941193009934 Protein with unknown function (DUF469); Region: DUF469; cl01237 941193009935 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 941193009936 putative deacylase active site [active] 941193009937 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 941193009938 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14464 941193009939 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 941193009940 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 941193009941 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 941193009942 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 941193009943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 941193009944 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193009945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193009946 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 941193009947 CoenzymeA binding site [chemical binding]; other site 941193009948 subunit interaction site [polypeptide binding]; other site 941193009949 PHB binding site; other site 941193009950 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 941193009951 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 941193009952 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 941193009953 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 941193009954 NADP binding site [chemical binding]; other site 941193009955 dimer interface [polypeptide binding]; other site 941193009956 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 941193009957 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 941193009958 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 941193009959 tandem repeat interface [polypeptide binding]; other site 941193009960 oligomer interface [polypeptide binding]; other site 941193009961 active site residues [active] 941193009962 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 941193009963 catalytic core [active] 941193009964 Putative sterol carrier protein [Lipid metabolism]; Region: COG3255 941193009965 Phosphotransferase enzyme family; Region: APH; pfam01636 941193009966 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 941193009967 putative active site [active] 941193009968 putative substrate binding site [chemical binding]; other site 941193009969 ATP binding site [chemical binding]; other site 941193009970 short chain dehydrogenase; Provisional; Region: PRK07035 941193009971 classical (c) SDRs; Region: SDR_c; cd05233 941193009972 NAD(P) binding site [chemical binding]; other site 941193009973 active site 941193009974 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 941193009975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193009976 NAD(P) binding site [chemical binding]; other site 941193009977 active site 941193009978 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 941193009979 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193009980 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 941193009981 dimerization interface [polypeptide binding]; other site 941193009982 substrate binding pocket [chemical binding]; other site 941193009983 hypothetical protein; Provisional; Region: PRK10621 941193009984 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 941193009985 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 941193009986 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 941193009987 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 941193009988 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 941193009989 putative NADH binding site [chemical binding]; other site 941193009990 putative active site [active] 941193009991 nudix motif; other site 941193009992 putative metal binding site [ion binding]; other site 941193009993 enoyl-CoA hydratase; Provisional; Region: PRK06142 941193009994 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941193009995 substrate binding site [chemical binding]; other site 941193009996 oxyanion hole (OAH) forming residues; other site 941193009997 trimer interface [polypeptide binding]; other site 941193009998 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 941193009999 arginine:agmatin antiporter; Provisional; Region: PRK10644 941193010000 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 941193010001 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 941193010002 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 941193010003 homodimer interface [polypeptide binding]; other site 941193010004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193010005 catalytic residue [active] 941193010006 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 941193010007 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 941193010008 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 941193010009 active site 941193010010 catalytic site [active] 941193010011 substrate binding site [chemical binding]; other site 941193010012 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 941193010013 RNA/DNA hybrid binding site [nucleotide binding]; other site 941193010014 active site 941193010015 Methyltransferase domain; Region: Methyltransf_11; pfam08241 941193010016 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 941193010017 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 941193010018 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 941193010019 N-acetyl-D-glucosamine binding site [chemical binding]; other site 941193010020 catalytic residue [active] 941193010021 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941193010022 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941193010023 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941193010024 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 941193010025 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 941193010026 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 941193010027 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 941193010028 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 941193010029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193010030 dimer interface [polypeptide binding]; other site 941193010031 conserved gate region; other site 941193010032 putative PBP binding loops; other site 941193010033 ABC-ATPase subunit interface; other site 941193010034 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 941193010035 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 941193010036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193010037 dimer interface [polypeptide binding]; other site 941193010038 conserved gate region; other site 941193010039 putative PBP binding loops; other site 941193010040 ABC-ATPase subunit interface; other site 941193010041 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 941193010042 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941193010043 Walker A/P-loop; other site 941193010044 ATP binding site [chemical binding]; other site 941193010045 Q-loop/lid; other site 941193010046 ABC transporter signature motif; other site 941193010047 Walker B; other site 941193010048 D-loop; other site 941193010049 H-loop/switch region; other site 941193010050 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 941193010051 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941193010052 Walker A/P-loop; other site 941193010053 ATP binding site [chemical binding]; other site 941193010054 Q-loop/lid; other site 941193010055 ABC transporter signature motif; other site 941193010056 Walker B; other site 941193010057 D-loop; other site 941193010058 H-loop/switch region; other site 941193010059 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 941193010060 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 941193010061 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 941193010062 NAD binding site [chemical binding]; other site 941193010063 homotetramer interface [polypeptide binding]; other site 941193010064 homodimer interface [polypeptide binding]; other site 941193010065 substrate binding site [chemical binding]; other site 941193010066 active site 941193010067 periplasmic folding chaperone; Provisional; Region: PRK10788 941193010068 SurA N-terminal domain; Region: SurA_N_3; pfam13624 941193010069 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 941193010070 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 941193010071 IHF dimer interface [polypeptide binding]; other site 941193010072 IHF - DNA interface [nucleotide binding]; other site 941193010073 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 941193010074 Found in ATP-dependent protease La (LON); Region: LON; smart00464 941193010075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193010076 Walker A motif; other site 941193010077 ATP binding site [chemical binding]; other site 941193010078 Walker B motif; other site 941193010079 arginine finger; other site 941193010080 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 941193010081 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 941193010082 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 941193010083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193010084 Walker A motif; other site 941193010085 ATP binding site [chemical binding]; other site 941193010086 Walker B motif; other site 941193010087 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 941193010088 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 941193010089 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 941193010090 oligomer interface [polypeptide binding]; other site 941193010091 active site residues [active] 941193010092 trigger factor; Provisional; Region: tig; PRK01490 941193010093 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 941193010094 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 941193010095 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 941193010096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193010097 active site 941193010098 phosphorylation site [posttranslational modification] 941193010099 intermolecular recognition site; other site 941193010100 dimerization interface [polypeptide binding]; other site 941193010101 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193010102 DNA binding site [nucleotide binding] 941193010103 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193010104 dimerization interface [polypeptide binding]; other site 941193010105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193010106 dimer interface [polypeptide binding]; other site 941193010107 phosphorylation site [posttranslational modification] 941193010108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193010109 ATP binding site [chemical binding]; other site 941193010110 Mg2+ binding site [ion binding]; other site 941193010111 G-X-G motif; other site 941193010112 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 941193010113 Beta-lactamase; Region: Beta-lactamase; pfam00144 941193010114 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 941193010115 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 941193010116 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 941193010117 homodimer interface [polypeptide binding]; other site 941193010118 NADP binding site [chemical binding]; other site 941193010119 substrate binding site [chemical binding]; other site 941193010120 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 941193010121 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 941193010122 active site 941193010123 HIGH motif; other site 941193010124 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 941193010125 KMSKS motif; other site 941193010126 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 941193010127 tRNA binding surface [nucleotide binding]; other site 941193010128 anticodon binding site; other site 941193010129 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 941193010130 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 941193010131 active site 941193010132 HIGH motif; other site 941193010133 nucleotide binding site [chemical binding]; other site 941193010134 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 941193010135 KMSKS motif; other site 941193010136 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 941193010137 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 941193010138 substrate binding site [chemical binding]; other site 941193010139 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 941193010140 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 941193010141 putative active site [active] 941193010142 putative metal binding site [ion binding]; other site 941193010143 SPFH domain / Band 7 family; Region: Band_7; pfam01145 941193010144 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 941193010145 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 941193010146 active site 941193010147 dinuclear metal binding site [ion binding]; other site 941193010148 dimerization interface [polypeptide binding]; other site 941193010149 universal stress protein UspE; Provisional; Region: PRK11175 941193010150 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 941193010151 Ligand Binding Site [chemical binding]; other site 941193010152 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 941193010153 Ligand Binding Site [chemical binding]; other site 941193010154 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 941193010155 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 941193010156 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 941193010157 substrate binding site [chemical binding]; other site 941193010158 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 941193010159 substrate binding site [chemical binding]; other site 941193010160 ligand binding site [chemical binding]; other site 941193010161 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 941193010162 NMT1-like family; Region: NMT1_2; pfam13379 941193010163 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 941193010164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193010165 active site 941193010166 phosphorylation site [posttranslational modification] 941193010167 intermolecular recognition site; other site 941193010168 dimerization interface [polypeptide binding]; other site 941193010169 ANTAR domain; Region: ANTAR; pfam03861 941193010170 Alginate lyase; Region: Alginate_lyase2; pfam08787 941193010171 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 941193010172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193010173 putative substrate translocation pore; other site 941193010174 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 941193010175 Protein kinase domain; Region: Pkinase; pfam00069 941193010176 Catalytic domain of Protein Kinases; Region: PKc; cd00180 941193010177 active site 941193010178 ATP binding site [chemical binding]; other site 941193010179 substrate binding site [chemical binding]; other site 941193010180 activation loop (A-loop); other site 941193010181 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 941193010182 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941193010183 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 941193010184 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 941193010185 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 941193010186 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 941193010187 [2Fe-2S] cluster binding site [ion binding]; other site 941193010188 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 941193010189 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 941193010190 [4Fe-4S] binding site [ion binding]; other site 941193010191 molybdopterin cofactor binding site; other site 941193010192 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 941193010193 molybdopterin cofactor binding site; other site 941193010194 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 941193010195 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 941193010196 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 941193010197 active site 941193010198 SAM binding site [chemical binding]; other site 941193010199 homodimer interface [polypeptide binding]; other site 941193010200 OprF membrane domain; Region: OprF; pfam05736 941193010201 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 941193010202 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 941193010203 ligand binding site [chemical binding]; other site 941193010204 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 941193010205 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941193010206 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941193010207 DNA binding residues [nucleotide binding] 941193010208 Mechanosensitive ion channel; Region: MS_channel; pfam00924 941193010209 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 941193010210 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 941193010211 Cl binding site [ion binding]; other site 941193010212 oligomer interface [polypeptide binding]; other site 941193010213 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 941193010214 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 941193010215 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 941193010216 phosphoenolpyruvate synthase; Validated; Region: PRK06464 941193010217 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 941193010218 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 941193010219 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 941193010220 PEP synthetase regulatory protein; Provisional; Region: PRK05339 941193010221 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 941193010222 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 941193010223 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 941193010224 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 941193010225 Maltose operon periplasmic protein precursor (MalM); Region: MalM; pfam07148 941193010226 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 941193010227 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 941193010228 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 941193010229 putative active site [active] 941193010230 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 941193010231 AAA ATPase domain; Region: AAA_16; pfam13191 941193010232 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193010233 DNA binding residues [nucleotide binding] 941193010234 dimerization interface [polypeptide binding]; other site 941193010235 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 941193010236 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193010237 DNA binding residues [nucleotide binding] 941193010238 dimerization interface [polypeptide binding]; other site 941193010239 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 941193010240 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 941193010241 chorismate binding enzyme; Region: Chorismate_bind; cl10555 941193010242 phosphoserine phosphatase; Provisional; Region: thrH; PRK13582 941193010243 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 941193010244 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 941193010245 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 941193010246 Active Sites [active] 941193010247 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 941193010248 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193010249 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 941193010250 substrate binding site [chemical binding]; other site 941193010251 dimerization interface [polypeptide binding]; other site 941193010252 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 941193010253 Ligand Binding Site [chemical binding]; other site 941193010254 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 941193010255 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 941193010256 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 941193010257 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 941193010258 catalytic residues [active] 941193010259 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 941193010260 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 941193010261 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941193010262 Coenzyme A binding pocket [chemical binding]; other site 941193010263 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 941193010264 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941193010265 substrate binding site [chemical binding]; other site 941193010266 oxyanion hole (OAH) forming residues; other site 941193010267 trimer interface [polypeptide binding]; other site 941193010268 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 941193010269 ADP-ribose binding site [chemical binding]; other site 941193010270 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 941193010271 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 941193010272 catalytic triad [active] 941193010273 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 941193010274 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 941193010275 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 941193010276 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 941193010277 active site 941193010278 catalytic tetrad [active] 941193010279 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193010280 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193010281 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 941193010282 putative effector binding pocket; other site 941193010283 putative dimerization interface [polypeptide binding]; other site 941193010284 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 941193010285 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941193010286 substrate binding site [chemical binding]; other site 941193010287 oxyanion hole (OAH) forming residues; other site 941193010288 trimer interface [polypeptide binding]; other site 941193010289 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 941193010290 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 941193010291 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 941193010292 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 941193010293 dimer interface [polypeptide binding]; other site 941193010294 active site 941193010295 Predicted permeases [General function prediction only]; Region: COG0679 941193010296 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 941193010297 Cytochrome c; Region: Cytochrom_C; pfam00034 941193010298 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 941193010299 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 941193010300 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 941193010301 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 941193010302 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 941193010303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 941193010304 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 941193010305 Uncharacterized conserved protein [Function unknown]; Region: COG2308 941193010306 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 941193010307 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 941193010308 catalytic triad [active] 941193010309 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 941193010310 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 941193010311 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 941193010312 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 941193010313 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193010314 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193010315 metal binding site [ion binding]; metal-binding site 941193010316 active site 941193010317 I-site; other site 941193010318 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941193010319 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 941193010320 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 941193010321 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 941193010322 Switch II region; other site 941193010323 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 941193010324 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 941193010325 Flagellar assembly protein FliH; Region: FliH; pfam02108 941193010326 YOP proteins translocation protein K (YscK); Region: YscK; pfam06578 941193010327 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 941193010328 type III secretion apparatus protein, YscI/HrpB, C-terminal domain; Region: yscI_hrpB_dom; TIGR02497 941193010329 YopR Core; Region: YopR_core; cl07585 941193010330 Bacterial type II secretion system chaperone protein (type_III_yscG); Region: Type_III_YscG; pfam09477 941193010331 Type III secretion needle MxiH like; Region: MxiH; cl09641 941193010332 Protein of unknown function (DUF1895); Region: DUF1895; cl07553 941193010333 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 941193010334 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 941193010335 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 941193010336 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 941193010337 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 941193010338 type III secretion system chaperone, YscB family; Region: type_III_yscB; TIGR02513 941193010339 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 941193010340 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941193010341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193010342 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193010343 type III secretion system chaperone YscW; Region: YscW; TIGR02567 941193010344 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 941193010345 YopD protein; Region: YopD; pfam05844 941193010346 Uncharacterized conserved protein [Function unknown]; Region: COG5613 941193010347 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 941193010348 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941193010349 binding surface 941193010350 TPR motif; other site 941193010351 V antigen (LcrV) protein; Region: LcrV; pfam04792 941193010352 LcrG protein; Region: LcrG; cl06311 941193010353 type III secretion system regulator LcrR; Region: LcrR; TIGR02572 941193010354 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 941193010355 FHIPEP family; Region: FHIPEP; pfam00771 941193010356 type III secretion protein, YscX family; Region: type_III_YscX; TIGR02502 941193010357 type III secretion chaperone SycN; Region: type_III_SycN; TIGR02503 941193010358 TyeA; Region: TyeA; pfam09059 941193010359 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 941193010360 type III secretion system ATPase; Provisional; Region: PRK06936 941193010361 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 941193010362 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 941193010363 Walker A motif/ATP binding site; other site 941193010364 Walker B motif; other site 941193010365 Type III secretion protein YscO; Region: YscO; pfam07321 941193010366 type III secretion system needle length determinant; Region: type_III_yscP; TIGR02514 941193010367 type III secretion system protein; Validated; Region: PRK06933 941193010368 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 941193010369 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 941193010370 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 941193010371 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 941193010372 Type III secretory pathway, component EscU [Intracellular trafficking and secretion]; Region: EscU; COG4792 941193010373 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 941193010374 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 941193010375 Sulfatase; Region: Sulfatase; pfam00884 941193010376 Uncharacterized conserved protein [Function unknown]; Region: COG3391 941193010377 Strictosidine synthase; Region: Str_synth; pfam03088 941193010378 spermidine synthase; Provisional; Region: PRK00811 941193010379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193010380 S-adenosylmethionine binding site [chemical binding]; other site 941193010381 AlkA N-terminal domain; Region: AlkA_N; pfam06029 941193010382 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 941193010383 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 941193010384 minor groove reading motif; other site 941193010385 helix-hairpin-helix signature motif; other site 941193010386 substrate binding pocket [chemical binding]; other site 941193010387 active site 941193010388 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 941193010389 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 941193010390 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 941193010391 Cupin domain; Region: Cupin_2; cl17218 941193010392 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 941193010393 intersubunit interface [polypeptide binding]; other site 941193010394 active site 941193010395 Zn2+ binding site [ion binding]; other site 941193010396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193010397 putative substrate translocation pore; other site 941193010398 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 941193010399 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 941193010400 Tetramer interface [polypeptide binding]; other site 941193010401 active site 941193010402 FMN-binding site [chemical binding]; other site 941193010403 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 941193010404 HemK family putative methylases; Region: hemK_fam; TIGR00536 941193010405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193010406 S-adenosylmethionine binding site [chemical binding]; other site 941193010407 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 941193010408 Isochorismatase family; Region: Isochorismatase; pfam00857 941193010409 catalytic triad [active] 941193010410 conserved cis-peptide bond; other site 941193010411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 941193010412 Smr domain; Region: Smr; pfam01713 941193010413 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 941193010414 homodecamer interface [polypeptide binding]; other site 941193010415 GTP cyclohydrolase I; Provisional; Region: PLN03044 941193010416 active site 941193010417 putative catalytic site residues [active] 941193010418 zinc binding site [ion binding]; other site 941193010419 GTP-CH-I/GFRP interaction surface; other site 941193010420 Hemerythrin; Region: Hemerythrin; cd12107 941193010421 Fe binding site [ion binding]; other site 941193010422 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 941193010423 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941193010424 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 941193010425 Catalytic domain of Protein Kinases; Region: PKc; cd00180 941193010426 active site 941193010427 ATP binding site [chemical binding]; other site 941193010428 substrate binding site [chemical binding]; other site 941193010429 activation loop (A-loop); other site 941193010430 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 941193010431 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 941193010432 Protein phosphatase 2C; Region: PP2C; pfam00481 941193010433 active site 941193010434 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 941193010435 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 941193010436 G1 box; other site 941193010437 GTP/Mg2+ binding site [chemical binding]; other site 941193010438 G2 box; other site 941193010439 Switch I region; other site 941193010440 G3 box; other site 941193010441 Switch II region; other site 941193010442 G4 box; other site 941193010443 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 941193010444 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 941193010445 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 941193010446 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 941193010447 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 941193010448 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 941193010449 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 941193010450 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 941193010451 phosphopeptide binding site; other site 941193010452 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 941193010453 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 941193010454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193010455 Walker A motif; other site 941193010456 ATP binding site [chemical binding]; other site 941193010457 Walker B motif; other site 941193010458 arginine finger; other site 941193010459 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941193010460 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 941193010461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193010462 Walker A motif; other site 941193010463 ATP binding site [chemical binding]; other site 941193010464 Walker B motif; other site 941193010465 arginine finger; other site 941193010466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193010467 Walker A motif; other site 941193010468 ATP binding site [chemical binding]; other site 941193010469 Walker B motif; other site 941193010470 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 941193010471 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 941193010472 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 941193010473 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 941193010474 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 941193010475 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 941193010476 Protein of unknown function (DUF877); Region: DUF877; pfam05943 941193010477 Protein of unknown function (DUF770); Region: DUF770; pfam05591 941193010478 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 941193010479 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 941193010480 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 941193010481 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 941193010482 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 941193010483 putative C-terminal domain interface [polypeptide binding]; other site 941193010484 putative GSH binding site (G-site) [chemical binding]; other site 941193010485 putative dimer interface [polypeptide binding]; other site 941193010486 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 941193010487 N-terminal domain interface [polypeptide binding]; other site 941193010488 dimer interface [polypeptide binding]; other site 941193010489 substrate binding pocket (H-site) [chemical binding]; other site 941193010490 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 941193010491 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941193010492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193010493 homodimer interface [polypeptide binding]; other site 941193010494 catalytic residue [active] 941193010495 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941193010496 MarR family; Region: MarR_2; pfam12802 941193010497 benzoate transporter; Region: benE; TIGR00843 941193010498 Benzoate membrane transport protein; Region: BenE; pfam03594 941193010499 bile acid transporter; Region: bass; TIGR00841 941193010500 Sodium Bile acid symporter family; Region: SBF; cl17470 941193010501 short chain dehydrogenase; Provisional; Region: PRK06172 941193010502 classical (c) SDRs; Region: SDR_c; cd05233 941193010503 NAD(P) binding site [chemical binding]; other site 941193010504 active site 941193010505 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 941193010506 Prostaglandin dehydrogenases; Region: PGDH; cd05288 941193010507 NAD(P) binding site [chemical binding]; other site 941193010508 substrate binding site [chemical binding]; other site 941193010509 dimer interface [polypeptide binding]; other site 941193010510 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 941193010511 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 941193010512 Sulfate transporter family; Region: Sulfate_transp; pfam00916 941193010513 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 941193010514 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193010515 dimerization interface [polypeptide binding]; other site 941193010516 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941193010517 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193010518 dimer interface [polypeptide binding]; other site 941193010519 putative CheW interface [polypeptide binding]; other site 941193010520 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 941193010521 Uncharacterized conserved protein [Function unknown]; Region: COG3791 941193010522 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 941193010523 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 941193010524 active site residue [active] 941193010525 selenophosphate synthetase; Provisional; Region: PRK00943 941193010526 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 941193010527 dimerization interface [polypeptide binding]; other site 941193010528 putative ATP binding site [chemical binding]; other site 941193010529 hypothetical protein; Provisional; Region: PRK10279 941193010530 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 941193010531 active site 941193010532 nucleophile elbow; other site 941193010533 glutaminase; Provisional; Region: PRK00971 941193010534 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 941193010535 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 941193010536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193010537 active site 941193010538 phosphorylation site [posttranslational modification] 941193010539 intermolecular recognition site; other site 941193010540 dimerization interface [polypeptide binding]; other site 941193010541 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193010542 DNA binding site [nucleotide binding] 941193010543 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 941193010544 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 941193010545 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 941193010546 Ligand Binding Site [chemical binding]; other site 941193010547 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 941193010548 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193010549 dimer interface [polypeptide binding]; other site 941193010550 phosphorylation site [posttranslational modification] 941193010551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193010552 ATP binding site [chemical binding]; other site 941193010553 Mg2+ binding site [ion binding]; other site 941193010554 G-X-G motif; other site 941193010555 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 941193010556 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 941193010557 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941193010558 Soluble P-type ATPase [General function prediction only]; Region: COG4087 941193010559 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 941193010560 potassium-transporting ATPase subunit F; Provisional; Region: kdbF; PRK14740 941193010561 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941193010562 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193010563 active site 941193010564 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 941193010565 Transcriptional regulator [Transcription]; Region: IclR; COG1414 941193010566 Bacterial transcriptional regulator; Region: IclR; pfam01614 941193010567 enoyl-CoA hydratase; Provisional; Region: PRK08138 941193010568 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941193010569 substrate binding site [chemical binding]; other site 941193010570 oxyanion hole (OAH) forming residues; other site 941193010571 trimer interface [polypeptide binding]; other site 941193010572 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 941193010573 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 941193010574 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 941193010575 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 941193010576 Transcriptional regulators [Transcription]; Region: FadR; COG2186 941193010577 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193010578 DNA-binding site [nucleotide binding]; DNA binding site 941193010579 FCD domain; Region: FCD; pfam07729 941193010580 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 941193010581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193010582 putative substrate translocation pore; other site 941193010583 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 941193010584 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 941193010585 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 941193010586 C-terminal domain interface [polypeptide binding]; other site 941193010587 GSH binding site (G-site) [chemical binding]; other site 941193010588 dimer interface [polypeptide binding]; other site 941193010589 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 941193010590 N-terminal domain interface [polypeptide binding]; other site 941193010591 dimer interface [polypeptide binding]; other site 941193010592 substrate binding pocket (H-site) [chemical binding]; other site 941193010593 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 941193010594 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 941193010595 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 941193010596 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 941193010597 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 941193010598 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941193010599 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193010600 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 941193010601 CoenzymeA binding site [chemical binding]; other site 941193010602 subunit interaction site [polypeptide binding]; other site 941193010603 PHB binding site; other site 941193010604 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 941193010605 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 941193010606 acyl-activating enzyme (AAE) consensus motif; other site 941193010607 putative AMP binding site [chemical binding]; other site 941193010608 putative active site [active] 941193010609 putative CoA binding site [chemical binding]; other site 941193010610 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 941193010611 catalytic core [active] 941193010612 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 941193010613 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 941193010614 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 941193010615 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 941193010616 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 941193010617 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 941193010618 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG2984 941193010619 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193010620 dimerization interface [polypeptide binding]; other site 941193010621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193010622 dimer interface [polypeptide binding]; other site 941193010623 phosphorylation site [posttranslational modification] 941193010624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193010625 ATP binding site [chemical binding]; other site 941193010626 Mg2+ binding site [ion binding]; other site 941193010627 G-X-G motif; other site 941193010628 Response regulator receiver domain; Region: Response_reg; pfam00072 941193010629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193010630 active site 941193010631 phosphorylation site [posttranslational modification] 941193010632 intermolecular recognition site; other site 941193010633 dimerization interface [polypeptide binding]; other site 941193010634 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 941193010635 active site 1 [active] 941193010636 dimer interface [polypeptide binding]; other site 941193010637 active site 2 [active] 941193010638 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 941193010639 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 941193010640 dimer interface [polypeptide binding]; other site 941193010641 active site 941193010642 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 941193010643 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193010644 dimerization interface [polypeptide binding]; other site 941193010645 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941193010646 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193010647 dimer interface [polypeptide binding]; other site 941193010648 putative CheW interface [polypeptide binding]; other site 941193010649 Predicted transcriptional regulators [Transcription]; Region: COG1733 941193010650 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 941193010651 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 941193010652 Amidohydrolase; Region: Amidohydro_2; pfam04909 941193010653 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 941193010654 membrane-bound complex binding site; other site 941193010655 hinge residues; other site 941193010656 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941193010657 MarR family; Region: MarR; pfam01047 941193010658 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 941193010659 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941193010660 catalytic loop [active] 941193010661 iron binding site [ion binding]; other site 941193010662 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 941193010663 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 941193010664 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 941193010665 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 941193010666 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 941193010667 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 941193010668 cytochrome c-550; Provisional; Region: psbV; cl17239 941193010669 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 941193010670 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 941193010671 Cupin domain; Region: Cupin_2; cl17218 941193010672 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941193010673 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193010674 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193010675 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 941193010676 oligomerization interface [polypeptide binding]; other site 941193010677 active site 941193010678 metal binding site [ion binding]; metal-binding site 941193010679 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 941193010680 heat shock protein 90; Provisional; Region: PRK05218 941193010681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193010682 ATP binding site [chemical binding]; other site 941193010683 Mg2+ binding site [ion binding]; other site 941193010684 G-X-G motif; other site 941193010685 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 941193010686 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 941193010687 CoenzymeA binding site [chemical binding]; other site 941193010688 subunit interaction site [polypeptide binding]; other site 941193010689 PHB binding site; other site 941193010690 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 941193010691 CoenzymeA binding site [chemical binding]; other site 941193010692 subunit interaction site [polypeptide binding]; other site 941193010693 PHB binding site; other site 941193010694 Predicted membrane protein [Function unknown]; Region: COG3821 941193010695 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 941193010696 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 941193010697 CoA binding domain; Region: CoA_binding; pfam02629 941193010698 CoA-ligase; Region: Ligase_CoA; pfam00549 941193010699 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 941193010700 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 941193010701 CoA-ligase; Region: Ligase_CoA; pfam00549 941193010702 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 941193010703 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 941193010704 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941193010705 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 941193010706 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 941193010707 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 941193010708 E3 interaction surface; other site 941193010709 lipoyl attachment site [posttranslational modification]; other site 941193010710 e3 binding domain; Region: E3_binding; pfam02817 941193010711 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 941193010712 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 941193010713 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 941193010714 TPP-binding site [chemical binding]; other site 941193010715 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 941193010716 PYR/PP interface [polypeptide binding]; other site 941193010717 dimer interface [polypeptide binding]; other site 941193010718 TPP binding site [chemical binding]; other site 941193010719 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 941193010720 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 941193010721 L-aspartate oxidase; Provisional; Region: PRK06175 941193010722 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675 941193010723 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 941193010724 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 941193010725 proximal heme binding site [chemical binding]; other site 941193010726 Iron-sulfur protein interface; other site 941193010727 SdhC subunit interface [polypeptide binding]; other site 941193010728 proximal quinone binding site [chemical binding]; other site 941193010729 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 941193010730 SdhD (CybS) interface [polypeptide binding]; other site 941193010731 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 941193010732 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 941193010733 dimer interface [polypeptide binding]; other site 941193010734 active site 941193010735 citrylCoA binding site [chemical binding]; other site 941193010736 NADH binding [chemical binding]; other site 941193010737 cationic pore residues; other site 941193010738 oxalacetate/citrate binding site [chemical binding]; other site 941193010739 coenzyme A binding site [chemical binding]; other site 941193010740 catalytic triad [active] 941193010741 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 941193010742 putative lipid binding site [chemical binding]; other site 941193010743 Flagellin N-methylase; Region: FliB; pfam03692 941193010744 Protein of unknown function, DUF486; Region: DUF486; pfam04342 941193010745 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 941193010746 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 941193010747 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 941193010748 active site 941193010749 catalytic site [active] 941193010750 substrate binding site [chemical binding]; other site 941193010751 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 941193010752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 941193010753 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 941193010754 ATP-NAD kinase; Region: NAD_kinase; pfam01513 941193010755 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 941193010756 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193010757 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941193010758 dimerization interface [polypeptide binding]; other site 941193010759 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 941193010760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193010761 putative substrate translocation pore; other site 941193010762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193010763 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 941193010764 homotrimer interaction site [polypeptide binding]; other site 941193010765 putative active site [active] 941193010766 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 941193010767 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 941193010768 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 941193010769 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 941193010770 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 941193010771 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 941193010772 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 941193010773 CPxP motif; other site 941193010774 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 941193010775 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 941193010776 aconitate hydratase; Validated; Region: PRK09277 941193010777 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 941193010778 substrate binding site [chemical binding]; other site 941193010779 ligand binding site [chemical binding]; other site 941193010780 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 941193010781 substrate binding site [chemical binding]; other site 941193010782 PAS domain; Region: PAS_9; pfam13426 941193010783 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193010784 putative active site [active] 941193010785 heme pocket [chemical binding]; other site 941193010786 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941193010787 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193010788 dimer interface [polypeptide binding]; other site 941193010789 putative CheW interface [polypeptide binding]; other site 941193010790 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193010791 NAD(P) binding site [chemical binding]; other site 941193010792 active site 941193010793 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 941193010794 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 941193010795 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 941193010796 Low-spin heme binding site [chemical binding]; other site 941193010797 Putative water exit pathway; other site 941193010798 Binuclear center (active site) [active] 941193010799 Putative proton exit pathway; other site 941193010800 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 941193010801 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 941193010802 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 941193010803 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 941193010804 Cytochrome c; Region: Cytochrom_C; pfam00034 941193010805 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 941193010806 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 941193010807 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 941193010808 Low-spin heme binding site [chemical binding]; other site 941193010809 Putative water exit pathway; other site 941193010810 Binuclear center (active site) [active] 941193010811 Putative proton exit pathway; other site 941193010812 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 941193010813 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 941193010814 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 941193010815 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 941193010816 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 941193010817 Cytochrome c; Region: Cytochrom_C; cl11414 941193010818 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 941193010819 4Fe-4S binding domain; Region: Fer4_5; pfam12801 941193010820 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 941193010821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 941193010822 FixH; Region: FixH; pfam05751 941193010823 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 941193010824 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 941193010825 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941193010826 metal-binding site [ion binding] 941193010827 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941193010828 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941193010829 motif II; other site 941193010830 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 941193010831 Uncharacterized conserved protein [Function unknown]; Region: COG2836 941193010832 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 941193010833 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941193010834 FeS/SAM binding site; other site 941193010835 HemN C-terminal domain; Region: HemN_C; pfam06969 941193010836 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 941193010837 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 941193010838 ligand binding site [chemical binding]; other site 941193010839 flexible hinge region; other site 941193010840 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 941193010841 putative switch regulator; other site 941193010842 non-specific DNA interactions [nucleotide binding]; other site 941193010843 DNA binding site [nucleotide binding] 941193010844 sequence specific DNA binding site [nucleotide binding]; other site 941193010845 putative cAMP binding site [chemical binding]; other site 941193010846 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941193010847 active site 941193010848 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 941193010849 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 941193010850 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 941193010851 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 941193010852 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 941193010853 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 941193010854 short chain dehydrogenase; Provisional; Region: PRK06181 941193010855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193010856 NAD(P) binding site [chemical binding]; other site 941193010857 active site 941193010858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 941193010859 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941193010860 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193010861 active site 941193010862 recombination protein RecR; Reviewed; Region: recR; PRK00076 941193010863 RecR protein; Region: RecR; pfam02132 941193010864 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 941193010865 putative active site [active] 941193010866 putative metal-binding site [ion binding]; other site 941193010867 tetramer interface [polypeptide binding]; other site 941193010868 hypothetical protein; Validated; Region: PRK00153 941193010869 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 941193010870 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193010871 Walker A motif; other site 941193010872 ATP binding site [chemical binding]; other site 941193010873 Walker B motif; other site 941193010874 arginine finger; other site 941193010875 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 941193010876 Ligase N family; Region: LIGANc; smart00532 941193010877 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 941193010878 nucleotide binding pocket [chemical binding]; other site 941193010879 K-X-D-G motif; other site 941193010880 catalytic site [active] 941193010881 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 941193010882 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 941193010883 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 941193010884 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 941193010885 Dimer interface [polypeptide binding]; other site 941193010886 BRCT sequence motif; other site 941193010887 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 941193010888 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 941193010889 FtsZ protein binding site [polypeptide binding]; other site 941193010890 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 941193010891 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 941193010892 Walker A/P-loop; other site 941193010893 ATP binding site [chemical binding]; other site 941193010894 Q-loop/lid; other site 941193010895 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 941193010896 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 941193010897 ABC transporter signature motif; other site 941193010898 Walker B; other site 941193010899 D-loop; other site 941193010900 H-loop/switch region; other site 941193010901 Transcriptional regulators [Transcription]; Region: GntR; COG1802 941193010902 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193010903 DNA-binding site [nucleotide binding]; DNA binding site 941193010904 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 941193010905 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 941193010906 Fatty acid desaturase; Region: FA_desaturase; pfam00487 941193010907 Di-iron ligands [ion binding]; other site 941193010908 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 941193010909 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941193010910 catalytic loop [active] 941193010911 iron binding site [ion binding]; other site 941193010912 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 941193010913 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 941193010914 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 941193010915 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 941193010916 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 941193010917 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 941193010918 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 941193010919 XdhC Rossmann domain; Region: XdhC_C; pfam13478 941193010920 guanine deaminase; Provisional; Region: PRK09228 941193010921 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 941193010922 active site 941193010923 putative acetyltransferase YhhY; Provisional; Region: PRK10140 941193010924 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941193010925 Coenzyme A binding pocket [chemical binding]; other site 941193010926 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 941193010927 Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; pfam06315 941193010928 Transposase; Region: HTH_Tnp_1; pfam01527 941193010929 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 941193010930 HTH-like domain; Region: HTH_21; pfam13276 941193010931 Integrase core domain; Region: rve; pfam00665 941193010932 Integrase core domain; Region: rve_3; pfam13683 941193010933 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 941193010934 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 941193010935 ligand binding site [chemical binding]; other site 941193010936 NAD binding site [chemical binding]; other site 941193010937 catalytic site [active] 941193010938 homodimer interface [polypeptide binding]; other site 941193010939 Predicted transcriptional regulators [Transcription]; Region: COG1733 941193010940 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 941193010941 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 941193010942 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 941193010943 dimer interface [polypeptide binding]; other site 941193010944 active site 941193010945 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 941193010946 Secretin and TonB N terminus short domain; Region: STN; smart00965 941193010947 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 941193010948 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193010949 N-terminal plug; other site 941193010950 ligand-binding site [chemical binding]; other site 941193010951 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 941193010952 FecR protein; Region: FecR; pfam04773 941193010953 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 941193010954 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941193010955 DNA binding residues [nucleotide binding] 941193010956 multidrug efflux protein; Reviewed; Region: PRK01766 941193010957 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 941193010958 cation binding site [ion binding]; other site 941193010959 threonine and homoserine efflux system; Provisional; Region: PRK10532 941193010960 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941193010961 non-specific DNA binding site [nucleotide binding]; other site 941193010962 salt bridge; other site 941193010963 sequence-specific DNA binding site [nucleotide binding]; other site 941193010964 Cupin domain; Region: Cupin_2; pfam07883 941193010965 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 941193010966 dimer interface [polypeptide binding]; other site 941193010967 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 941193010968 putative deacylase active site [active] 941193010969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 941193010970 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941193010971 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 941193010972 dimer interface [polypeptide binding]; other site 941193010973 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 941193010974 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941193010975 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 941193010976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312 941193010977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 941193010978 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941193010979 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193010980 DNA binding residues [nucleotide binding] 941193010981 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 941193010982 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 941193010983 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 941193010984 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 941193010985 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 941193010986 ATP-grasp domain; Region: ATP-grasp_4; cl17255 941193010987 short chain dehydrogenase; Provisional; Region: PRK06523 941193010988 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193010989 NAD(P) binding site [chemical binding]; other site 941193010990 active site 941193010991 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 941193010992 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193010993 substrate binding pocket [chemical binding]; other site 941193010994 membrane-bound complex binding site; other site 941193010995 hinge residues; other site 941193010996 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 941193010997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193010998 dimer interface [polypeptide binding]; other site 941193010999 conserved gate region; other site 941193011000 putative PBP binding loops; other site 941193011001 ABC-ATPase subunit interface; other site 941193011002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193011003 dimer interface [polypeptide binding]; other site 941193011004 conserved gate region; other site 941193011005 putative PBP binding loops; other site 941193011006 ABC-ATPase subunit interface; other site 941193011007 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 941193011008 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 941193011009 Walker A/P-loop; other site 941193011010 ATP binding site [chemical binding]; other site 941193011011 Q-loop/lid; other site 941193011012 ABC transporter signature motif; other site 941193011013 Walker B; other site 941193011014 D-loop; other site 941193011015 H-loop/switch region; other site 941193011016 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 941193011017 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 941193011018 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 941193011019 homodimer interface [polypeptide binding]; other site 941193011020 active site 941193011021 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 941193011022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193011023 dimer interface [polypeptide binding]; other site 941193011024 phosphorylation site [posttranslational modification] 941193011025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193011026 ATP binding site [chemical binding]; other site 941193011027 Mg2+ binding site [ion binding]; other site 941193011028 G-X-G motif; other site 941193011029 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 941193011030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193011031 active site 941193011032 phosphorylation site [posttranslational modification] 941193011033 intermolecular recognition site; other site 941193011034 dimerization interface [polypeptide binding]; other site 941193011035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193011036 Walker A motif; other site 941193011037 ATP binding site [chemical binding]; other site 941193011038 Walker B motif; other site 941193011039 arginine finger; other site 941193011040 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941193011041 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 941193011042 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 941193011043 FMN binding site [chemical binding]; other site 941193011044 active site 941193011045 substrate binding site [chemical binding]; other site 941193011046 catalytic residue [active] 941193011047 Methyltransferase domain; Region: Methyltransf_23; pfam13489 941193011048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193011049 S-adenosylmethionine binding site [chemical binding]; other site 941193011050 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 941193011051 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 941193011052 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 941193011053 Transporter associated domain; Region: CorC_HlyC; smart01091 941193011054 short chain dehydrogenase; Provisional; Region: PRK09291 941193011055 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 941193011056 NADP binding site [chemical binding]; other site 941193011057 active site 941193011058 steroid binding site; other site 941193011059 Domain of unknown function (DUF336); Region: DUF336; cl01249 941193011060 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193011061 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193011062 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 941193011063 putative effector binding pocket; other site 941193011064 putative dimerization interface [polypeptide binding]; other site 941193011065 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 941193011066 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 941193011067 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 941193011068 active site 941193011069 substrate binding site [chemical binding]; other site 941193011070 Mg2+ binding site [ion binding]; other site 941193011071 threonine dehydratase; Reviewed; Region: PRK09224 941193011072 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 941193011073 tetramer interface [polypeptide binding]; other site 941193011074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193011075 catalytic residue [active] 941193011076 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 941193011077 putative Ile/Val binding site [chemical binding]; other site 941193011078 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 941193011079 putative Ile/Val binding site [chemical binding]; other site 941193011080 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 941193011081 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 941193011082 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 941193011083 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193011084 N-terminal plug; other site 941193011085 ligand-binding site [chemical binding]; other site 941193011086 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 941193011087 UbiA prenyltransferase family; Region: UbiA; pfam01040 941193011088 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 941193011089 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 941193011090 Subunit I/III interface [polypeptide binding]; other site 941193011091 Subunit III/IV interface [polypeptide binding]; other site 941193011092 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 941193011093 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 941193011094 D-pathway; other site 941193011095 Putative ubiquinol binding site [chemical binding]; other site 941193011096 Low-spin heme (heme b) binding site [chemical binding]; other site 941193011097 Putative water exit pathway; other site 941193011098 Binuclear center (heme o3/CuB) [ion binding]; other site 941193011099 K-pathway; other site 941193011100 Putative proton exit pathway; other site 941193011101 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 941193011102 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 941193011103 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 941193011104 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 941193011105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193011106 putative substrate translocation pore; other site 941193011107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193011108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193011109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 941193011110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193011111 putative substrate translocation pore; other site 941193011112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193011113 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193011114 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193011115 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941193011116 putative effector binding pocket; other site 941193011117 dimerization interface [polypeptide binding]; other site 941193011118 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 941193011119 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941193011120 motif II; other site 941193011121 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 941193011122 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941193011123 catalytic residue [active] 941193011124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193011125 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 941193011126 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941193011127 dimerization interface [polypeptide binding]; other site 941193011128 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 941193011129 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 941193011130 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 941193011131 putative active site [active] 941193011132 putative dimer interface [polypeptide binding]; other site 941193011133 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 941193011134 nucleotide binding site/active site [active] 941193011135 HIT family signature motif; other site 941193011136 catalytic residue [active] 941193011137 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 941193011138 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 941193011139 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 941193011140 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 941193011141 Catalytic site [active] 941193011142 Secretin and TonB N terminus short domain; Region: STN; smart00965 941193011143 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 941193011144 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193011145 N-terminal plug; other site 941193011146 ligand-binding site [chemical binding]; other site 941193011147 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 941193011148 FecR protein; Region: FecR; pfam04773 941193011149 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 941193011150 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941193011151 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 941193011152 DNA binding residues [nucleotide binding] 941193011153 hypothetical protein; Provisional; Region: PRK05170 941193011154 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 941193011155 putative metal binding site [ion binding]; other site 941193011156 putative homodimer interface [polypeptide binding]; other site 941193011157 putative homotetramer interface [polypeptide binding]; other site 941193011158 putative homodimer-homodimer interface [polypeptide binding]; other site 941193011159 putative allosteric switch controlling residues; other site 941193011160 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 941193011161 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 941193011162 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 941193011163 NAD binding site [chemical binding]; other site 941193011164 ligand binding site [chemical binding]; other site 941193011165 catalytic site [active] 941193011166 YcgL domain; Region: YcgL; pfam05166 941193011167 ribonuclease D; Region: rnd; TIGR01388 941193011168 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 941193011169 catalytic site [active] 941193011170 putative active site [active] 941193011171 putative substrate binding site [chemical binding]; other site 941193011172 HRDC domain; Region: HRDC; pfam00570 941193011173 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 941193011174 Strictosidine synthase; Region: Str_synth; pfam03088 941193011175 Transcriptional regulators [Transcription]; Region: GntR; COG1802 941193011176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193011177 DNA-binding site [nucleotide binding]; DNA binding site 941193011178 FCD domain; Region: FCD; pfam07729 941193011179 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 941193011180 Sulfate transporter family; Region: Sulfate_transp; pfam00916 941193011181 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 941193011182 active site 941193011183 homotetramer interface [polypeptide binding]; other site 941193011184 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 941193011185 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 941193011186 active site 941193011187 catalytic site [active] 941193011188 tetramer interface [polypeptide binding]; other site 941193011189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 941193011190 Allantoicase [Nucleotide transport and metabolism]; Region: Alc; COG4266 941193011191 Allantoicase repeat; Region: Allantoicase; pfam03561 941193011192 Allantoicase repeat; Region: Allantoicase; pfam03561 941193011193 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 941193011194 ureidoglycolate hydrolase; Provisional; Region: PRK03606 941193011195 Predicted membrane protein [Function unknown]; Region: COG3748 941193011196 Protein of unknown function (DUF989); Region: DUF989; pfam06181 941193011197 Cytochrome c; Region: Cytochrom_C; pfam00034 941193011198 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 941193011199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 941193011200 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 941193011201 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 941193011202 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 941193011203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 941193011204 PGAP1-like protein; Region: PGAP1; pfam07819 941193011205 PAAR motif; Region: PAAR_motif; pfam05488 941193011206 xanthine permease; Region: pbuX; TIGR03173 941193011207 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 941193011208 active site 941193011209 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 941193011210 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941193011211 FeS/SAM binding site; other site 941193011212 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 941193011213 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 941193011214 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193011215 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 941193011216 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 941193011217 glyoxylate carboligase; Provisional; Region: PRK11269 941193011218 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 941193011219 PYR/PP interface [polypeptide binding]; other site 941193011220 dimer interface [polypeptide binding]; other site 941193011221 TPP binding site [chemical binding]; other site 941193011222 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 941193011223 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 941193011224 TPP-binding site [chemical binding]; other site 941193011225 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 941193011226 tartronate semialdehyde reductase; Provisional; Region: PRK15059 941193011227 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 941193011228 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 941193011229 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 941193011230 MOFRL family; Region: MOFRL; pfam05161 941193011231 pyruvate kinase; Provisional; Region: PRK06247 941193011232 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 941193011233 domain interfaces; other site 941193011234 active site 941193011235 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 941193011236 Ion transport protein; Region: Ion_trans; pfam00520 941193011237 Ion channel; Region: Ion_trans_2; pfam07885 941193011238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 941193011239 conserved hypothetical protein; Region: TIGR02231 941193011240 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 941193011241 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 941193011242 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 941193011243 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 941193011244 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 941193011245 Domain of unknown function (DUF1937); Region: DUF1937; pfam09152 941193011246 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 941193011247 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 941193011248 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 941193011249 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 941193011250 Predicted dehydrogenase [General function prediction only]; Region: COG0579 941193011251 hydroxyglutarate oxidase; Provisional; Region: PRK11728 941193011252 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 941193011253 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 941193011254 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941193011255 Proteobacterial glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK_like_proteobact; cd07794 941193011256 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 941193011257 N- and C-terminal domain interface [polypeptide binding]; other site 941193011258 active site 941193011259 MgATP binding site [chemical binding]; other site 941193011260 catalytic site [active] 941193011261 metal binding site [ion binding]; metal-binding site 941193011262 putative homotetramer interface [polypeptide binding]; other site 941193011263 putative homodimer interface [polypeptide binding]; other site 941193011264 putative glycerol binding site [chemical binding]; other site 941193011265 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 941193011266 homodimer interface [polypeptide binding]; other site 941193011267 homotetramer interface [polypeptide binding]; other site 941193011268 active site pocket [active] 941193011269 cleavage site 941193011270 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 941193011271 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941193011272 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193011273 DNA binding residues [nucleotide binding] 941193011274 dimerization interface [polypeptide binding]; other site 941193011275 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 941193011276 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 941193011277 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 941193011278 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 941193011279 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 941193011280 catalytic residues [active] 941193011281 central insert; other site 941193011282 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 941193011283 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 941193011284 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 941193011285 heme exporter protein CcmC; Region: ccmC; TIGR01191 941193011286 heme exporter protein CcmB; Region: ccmB; TIGR01190 941193011287 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 941193011288 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 941193011289 Walker A/P-loop; other site 941193011290 ATP binding site [chemical binding]; other site 941193011291 Q-loop/lid; other site 941193011292 ABC transporter signature motif; other site 941193011293 Walker B; other site 941193011294 D-loop; other site 941193011295 H-loop/switch region; other site 941193011296 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 941193011297 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 941193011298 short chain dehydrogenase; Provisional; Region: PRK12937 941193011299 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 941193011300 NADP binding site [chemical binding]; other site 941193011301 homodimer interface [polypeptide binding]; other site 941193011302 active site 941193011303 substrate binding site [chemical binding]; other site 941193011304 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 941193011305 Predicted transcriptional regulator [Transcription]; Region: COG2378 941193011306 HTH domain; Region: HTH_11; pfam08279 941193011307 WYL domain; Region: WYL; pfam13280 941193011308 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 941193011309 C-terminal domain interface [polypeptide binding]; other site 941193011310 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 941193011311 GSH binding site (G-site) [chemical binding]; other site 941193011312 dimer interface [polypeptide binding]; other site 941193011313 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 941193011314 N-terminal domain interface [polypeptide binding]; other site 941193011315 dimer interface [polypeptide binding]; other site 941193011316 substrate binding pocket (H-site) [chemical binding]; other site 941193011317 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 941193011318 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 941193011319 putative CheA interaction surface; other site 941193011320 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 941193011321 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 941193011322 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 941193011323 P-loop; other site 941193011324 Magnesium ion binding site [ion binding]; other site 941193011325 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 941193011326 Magnesium ion binding site [ion binding]; other site 941193011327 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 941193011328 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 941193011329 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 941193011330 ligand binding site [chemical binding]; other site 941193011331 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 941193011332 flagellar motor protein; Reviewed; Region: motC; PRK09109 941193011333 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 941193011334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193011335 active site 941193011336 phosphorylation site [posttranslational modification] 941193011337 intermolecular recognition site; other site 941193011338 dimerization interface [polypeptide binding]; other site 941193011339 CheB methylesterase; Region: CheB_methylest; pfam01339 941193011340 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 941193011341 putative binding surface; other site 941193011342 active site 941193011343 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 941193011344 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 941193011345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193011346 ATP binding site [chemical binding]; other site 941193011347 Mg2+ binding site [ion binding]; other site 941193011348 G-X-G motif; other site 941193011349 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 941193011350 Chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheZ; COG3143 941193011351 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 941193011352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193011353 active site 941193011354 phosphorylation site [posttranslational modification] 941193011355 intermolecular recognition site; other site 941193011356 dimerization interface [polypeptide binding]; other site 941193011357 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 941193011358 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941193011359 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 941193011360 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941193011361 DNA binding residues [nucleotide binding] 941193011362 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 941193011363 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 941193011364 P-loop; other site 941193011365 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 941193011366 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941193011367 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 941193011368 FHIPEP family; Region: FHIPEP; pfam00771 941193011369 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 941193011370 Repair protein; Region: Repair_PSII; pfam04536 941193011371 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 941193011372 Repair protein; Region: Repair_PSII; pfam04536 941193011373 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 941193011374 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 941193011375 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 941193011376 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 941193011377 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 941193011378 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 941193011379 flagellar motor switch protein; Validated; Region: fliN; PRK05698 941193011380 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 941193011381 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 941193011382 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 941193011383 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696 941193011384 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 941193011385 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 941193011386 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 941193011387 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 941193011388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 941193011389 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 941193011390 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193011391 dimer interface [polypeptide binding]; other site 941193011392 phosphorylation site [posttranslational modification] 941193011393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193011394 ATP binding site [chemical binding]; other site 941193011395 Mg2+ binding site [ion binding]; other site 941193011396 G-X-G motif; other site 941193011397 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 941193011398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193011399 active site 941193011400 phosphorylation site [posttranslational modification] 941193011401 intermolecular recognition site; other site 941193011402 dimerization interface [polypeptide binding]; other site 941193011403 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193011404 DNA binding site [nucleotide binding] 941193011405 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 941193011406 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 941193011407 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193011408 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193011409 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 941193011410 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193011411 metal binding site [ion binding]; metal-binding site 941193011412 active site 941193011413 I-site; other site 941193011414 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941193011415 N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: LasI; COG3916 941193011416 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 941193011417 Autoinducer binding domain; Region: Autoind_bind; pfam03472 941193011418 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193011419 DNA binding residues [nucleotide binding] 941193011420 dimerization interface [polypeptide binding]; other site 941193011421 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 941193011422 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 941193011423 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941193011424 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 941193011425 Soluble P-type ATPase [General function prediction only]; Region: COG4087 941193011426 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 941193011427 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 941193011428 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 941193011429 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 941193011430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193011431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193011432 Walker A/P-loop; other site 941193011433 Walker A/P-loop; other site 941193011434 ATP binding site [chemical binding]; other site 941193011435 ATP binding site [chemical binding]; other site 941193011436 Q-loop/lid; other site 941193011437 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193011438 Q-loop/lid; other site 941193011439 ABC transporter signature motif; other site 941193011440 ABC transporter signature motif; other site 941193011441 Walker B; other site 941193011442 Walker B; other site 941193011443 D-loop; other site 941193011444 H-loop/switch region; other site 941193011445 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941193011446 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 941193011447 Uncharacterized conserved protein [Function unknown]; Region: COG3148 941193011448 PAS domain; Region: PAS_9; pfam13426 941193011449 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193011450 putative active site [active] 941193011451 heme pocket [chemical binding]; other site 941193011452 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193011453 PAS domain; Region: PAS_9; pfam13426 941193011454 putative active site [active] 941193011455 heme pocket [chemical binding]; other site 941193011456 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941193011457 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193011458 dimer interface [polypeptide binding]; other site 941193011459 putative CheW interface [polypeptide binding]; other site 941193011460 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193011461 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193011462 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941193011463 dimerization interface [polypeptide binding]; other site 941193011464 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 941193011465 agmatinase; Region: agmatinase; TIGR01230 941193011466 oligomer interface [polypeptide binding]; other site 941193011467 putative active site [active] 941193011468 Mn binding site [ion binding]; other site 941193011469 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 941193011470 SnoaL-like domain; Region: SnoaL_3; pfam13474 941193011471 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 941193011472 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 941193011473 Na binding site [ion binding]; other site 941193011474 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 941193011475 Na binding site [ion binding]; other site 941193011476 hypothetical protein; Provisional; Region: PRK07524 941193011477 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 941193011478 PYR/PP interface [polypeptide binding]; other site 941193011479 dimer interface [polypeptide binding]; other site 941193011480 TPP binding site [chemical binding]; other site 941193011481 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 941193011482 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 941193011483 TPP-binding site [chemical binding]; other site 941193011484 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 941193011485 FAD binding domain; Region: FAD_binding_4; pfam01565 941193011486 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941193011487 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193011488 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193011489 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 941193011490 putative dimerization interface [polypeptide binding]; other site 941193011491 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 941193011492 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 941193011493 EamA-like transporter family; Region: EamA; pfam00892 941193011494 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 941193011495 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 941193011496 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 941193011497 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 941193011498 active site 941193011499 Zn binding site [ion binding]; other site 941193011500 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 941193011501 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 941193011502 Mechanosensitive ion channel; Region: MS_channel; pfam00924 941193011503 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 941193011504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193011505 S-adenosylmethionine binding site [chemical binding]; other site 941193011506 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 941193011507 active site 941193011508 NTP binding site [chemical binding]; other site 941193011509 metal binding triad [ion binding]; metal-binding site 941193011510 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 941193011511 Family description; Region: UvrD_C_2; pfam13538 941193011512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193011513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193011514 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 941193011515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 941193011516 Methyltransferase domain; Region: Methyltransf_24; pfam13578 941193011517 Predicted ester cyclase [General function prediction only]; Region: COG5485 941193011518 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 941193011519 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 941193011520 ATP-grasp domain; Region: ATP-grasp_4; cl17255 941193011521 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 941193011522 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 941193011523 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 941193011524 carboxyltransferase (CT) interaction site; other site 941193011525 biotinylation site [posttranslational modification]; other site 941193011526 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 941193011527 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 941193011528 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193011529 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193011530 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 941193011531 substrate binding pocket [chemical binding]; other site 941193011532 dimerization interface [polypeptide binding]; other site 941193011533 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941193011534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193011535 active site 941193011536 phosphorylation site [posttranslational modification] 941193011537 intermolecular recognition site; other site 941193011538 dimerization interface [polypeptide binding]; other site 941193011539 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193011540 DNA binding residues [nucleotide binding] 941193011541 dimerization interface [polypeptide binding]; other site 941193011542 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941193011543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193011544 dimer interface [polypeptide binding]; other site 941193011545 phosphorylation site [posttranslational modification] 941193011546 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 941193011547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193011548 ATP binding site [chemical binding]; other site 941193011549 Mg2+ binding site [ion binding]; other site 941193011550 G-X-G motif; other site 941193011551 Response regulator receiver domain; Region: Response_reg; pfam00072 941193011552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193011553 active site 941193011554 phosphorylation site [posttranslational modification] 941193011555 intermolecular recognition site; other site 941193011556 dimerization interface [polypeptide binding]; other site 941193011557 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 941193011558 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 941193011559 active site residue [active] 941193011560 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 941193011561 active site residue [active] 941193011562 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 941193011563 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193011564 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193011565 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 941193011566 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 941193011567 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 941193011568 catalytic residues [active] 941193011569 dimer interface [polypeptide binding]; other site 941193011570 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941193011571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193011572 MarR family; Region: MarR_2; pfam12802 941193011573 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 941193011574 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 941193011575 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193011576 active site 941193011577 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 941193011578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193011579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193011580 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 941193011581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193011582 cobalamin synthase; Reviewed; Region: cobS; PRK00235 941193011583 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 941193011584 catalytic core [active] 941193011585 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 941193011586 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 941193011587 putative dimer interface [polypeptide binding]; other site 941193011588 active site pocket [active] 941193011589 putative cataytic base [active] 941193011590 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 941193011591 homotrimer interface [polypeptide binding]; other site 941193011592 Walker A motif; other site 941193011593 GTP binding site [chemical binding]; other site 941193011594 Walker B motif; other site 941193011595 cobyric acid synthase; Provisional; Region: PRK00784 941193011596 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 941193011597 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 941193011598 catalytic triad [active] 941193011599 threonine-phosphate decarboxylase; Reviewed; Region: PRK05664 941193011600 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 941193011601 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941193011602 catalytic residue [active] 941193011603 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 941193011604 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 941193011605 FMN binding site [chemical binding]; other site 941193011606 dimer interface [polypeptide binding]; other site 941193011607 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 941193011608 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 941193011609 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 941193011610 catalytic triad [active] 941193011611 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 941193011612 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 941193011613 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 941193011614 homodimer interface [polypeptide binding]; other site 941193011615 Walker A motif; other site 941193011616 ATP binding site [chemical binding]; other site 941193011617 hydroxycobalamin binding site [chemical binding]; other site 941193011618 Walker B motif; other site 941193011619 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 941193011620 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193011621 N-terminal plug; other site 941193011622 ligand-binding site [chemical binding]; other site 941193011623 Fusaric acid resistance protein family; Region: FUSC; pfam04632 941193011624 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 941193011625 Transcriptional regulators [Transcription]; Region: GntR; COG1802 941193011626 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193011627 DNA-binding site [nucleotide binding]; DNA binding site 941193011628 FCD domain; Region: FCD; pfam07729 941193011629 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 941193011630 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 941193011631 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 941193011632 hydroxyglutarate oxidase; Provisional; Region: PRK11728 941193011633 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 941193011634 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 941193011635 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 941193011636 EamA-like transporter family; Region: EamA; pfam00892 941193011637 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193011638 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193011639 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193011640 HTH domain; Region: HTH_11; pfam08279 941193011641 Helix-turn-helix domain; Region: HTH_31; pfam13560 941193011642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193011643 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 941193011644 putative substrate translocation pore; other site 941193011645 PAS fold; Region: PAS_4; pfam08448 941193011646 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193011647 putative active site [active] 941193011648 heme pocket [chemical binding]; other site 941193011649 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193011650 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941193011651 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193011652 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941193011653 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193011654 substrate binding pocket [chemical binding]; other site 941193011655 membrane-bound complex binding site; other site 941193011656 hinge residues; other site 941193011657 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 941193011658 substrate binding site [chemical binding]; other site 941193011659 Protein of unknown function (DUF521); Region: DUF521; pfam04412 941193011660 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 941193011661 substrate binding site [chemical binding]; other site 941193011662 ligand binding site [chemical binding]; other site 941193011663 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 941193011664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193011665 dimer interface [polypeptide binding]; other site 941193011666 conserved gate region; other site 941193011667 putative PBP binding loops; other site 941193011668 ABC-ATPase subunit interface; other site 941193011669 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 941193011670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193011671 dimer interface [polypeptide binding]; other site 941193011672 conserved gate region; other site 941193011673 putative PBP binding loops; other site 941193011674 ABC-ATPase subunit interface; other site 941193011675 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 941193011676 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 941193011677 Walker A/P-loop; other site 941193011678 ATP binding site [chemical binding]; other site 941193011679 Q-loop/lid; other site 941193011680 ABC transporter signature motif; other site 941193011681 Walker B; other site 941193011682 D-loop; other site 941193011683 H-loop/switch region; other site 941193011684 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 941193011685 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 941193011686 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 941193011687 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 941193011688 inhibitor site; inhibition site 941193011689 active site 941193011690 dimer interface [polypeptide binding]; other site 941193011691 catalytic residue [active] 941193011692 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 941193011693 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 941193011694 dimer interface [polypeptide binding]; other site 941193011695 NADP binding site [chemical binding]; other site 941193011696 catalytic residues [active] 941193011697 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 941193011698 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 941193011699 HAMP domain; Region: HAMP; pfam00672 941193011700 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941193011701 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193011702 dimer interface [polypeptide binding]; other site 941193011703 putative CheW interface [polypeptide binding]; other site 941193011704 Protease inhibitor Inh; Region: Inh; pfam02974 941193011705 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 941193011706 active site 941193011707 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 941193011708 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 941193011709 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 941193011710 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193011711 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193011712 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 941193011713 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941193011714 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193011715 Walker A/P-loop; other site 941193011716 ATP binding site [chemical binding]; other site 941193011717 Q-loop/lid; other site 941193011718 ABC transporter signature motif; other site 941193011719 Walker B; other site 941193011720 D-loop; other site 941193011721 H-loop/switch region; other site 941193011722 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 941193011723 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 941193011724 GAF domain; Region: GAF; pfam01590 941193011725 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193011726 PAS domain; Region: PAS_9; pfam13426 941193011727 putative active site [active] 941193011728 heme pocket [chemical binding]; other site 941193011729 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941193011730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193011731 dimer interface [polypeptide binding]; other site 941193011732 phosphorylation site [posttranslational modification] 941193011733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193011734 ATP binding site [chemical binding]; other site 941193011735 Mg2+ binding site [ion binding]; other site 941193011736 G-X-G motif; other site 941193011737 Response regulator receiver domain; Region: Response_reg; pfam00072 941193011738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193011739 active site 941193011740 phosphorylation site [posttranslational modification] 941193011741 intermolecular recognition site; other site 941193011742 dimerization interface [polypeptide binding]; other site 941193011743 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 941193011744 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 941193011745 active site 941193011746 catalytic residues [active] 941193011747 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193011748 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193011749 enoyl-CoA hydratase; Provisional; Region: PRK06563 941193011750 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941193011751 substrate binding site [chemical binding]; other site 941193011752 oxyanion hole (OAH) forming residues; other site 941193011753 trimer interface [polypeptide binding]; other site 941193011754 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 941193011755 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 941193011756 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 941193011757 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193011758 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941193011759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193011760 putative substrate translocation pore; other site 941193011761 Cupin domain; Region: Cupin_2; pfam07883 941193011762 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941193011763 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193011764 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193011765 Alkyl hydroperoxide reductase, large subunit [Posttranslational modification, protein turnover, chaperones]; Region: AhpF; COG3634 941193011766 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 941193011767 Fusaric acid resistance protein family; Region: FUSC; pfam04632 941193011768 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 941193011769 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193011770 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193011771 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941193011772 Phosphotransferase enzyme family; Region: APH; pfam01636 941193011773 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193011774 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193011775 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 941193011776 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941193011777 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 941193011778 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941193011779 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193011780 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193011781 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 941193011782 putative substrate binding pocket [chemical binding]; other site 941193011783 putative dimerization interface [polypeptide binding]; other site 941193011784 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 941193011785 MltA specific insert domain; Region: MltA; pfam03562 941193011786 3D domain; Region: 3D; pfam06725 941193011787 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 941193011788 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 941193011789 acyl-activating enzyme (AAE) consensus motif; other site 941193011790 AMP binding site [chemical binding]; other site 941193011791 Thioesterase domain; Region: Thioesterase; pfam00975 941193011792 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 941193011793 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 941193011794 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 941193011795 active site 941193011796 catalytic residues [active] 941193011797 metal binding site [ion binding]; metal-binding site 941193011798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193011799 S-adenosylmethionine binding site [chemical binding]; other site 941193011800 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 941193011801 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 941193011802 acyl-activating enzyme (AAE) consensus motif; other site 941193011803 AMP binding site [chemical binding]; other site 941193011804 active site 941193011805 CoA binding site [chemical binding]; other site 941193011806 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 941193011807 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 941193011808 active site 941193011809 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 941193011810 Ligand Binding Site [chemical binding]; other site 941193011811 Molecular Tunnel; other site 941193011812 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 941193011813 substrate binding pocket [chemical binding]; other site 941193011814 active site 941193011815 iron coordination sites [ion binding]; other site 941193011816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193011817 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941193011818 putative substrate translocation pore; other site 941193011819 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 941193011820 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 941193011821 Pirin-related protein [General function prediction only]; Region: COG1741 941193011822 Pirin; Region: Pirin; pfam02678 941193011823 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 941193011824 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 941193011825 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 941193011826 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 941193011827 active site residue [active] 941193011828 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 941193011829 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 941193011830 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 941193011831 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 941193011832 TrkA-N domain; Region: TrkA_N; pfam02254 941193011833 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 941193011834 putative hydrophobic ligand binding site [chemical binding]; other site 941193011835 Pirin-related protein [General function prediction only]; Region: COG1741 941193011836 Pirin; Region: Pirin; pfam02678 941193011837 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 941193011838 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941193011839 Predicted flavoprotein [General function prediction only]; Region: COG0431 941193011840 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 941193011841 Isochorismatase family; Region: Isochorismatase; pfam00857 941193011842 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 941193011843 catalytic triad [active] 941193011844 dimer interface [polypeptide binding]; other site 941193011845 conserved cis-peptide bond; other site 941193011846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193011847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193011848 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941193011849 putative effector binding pocket; other site 941193011850 dimerization interface [polypeptide binding]; other site 941193011851 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 941193011852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193011853 S-adenosylmethionine binding site [chemical binding]; other site 941193011854 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 941193011855 NlpC/P60 family; Region: NLPC_P60; pfam00877 941193011856 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 941193011857 NlpC/P60 family; Region: NLPC_P60; pfam00877 941193011858 NAD-dependent deacetylase; Provisional; Region: PRK00481 941193011859 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 941193011860 NAD+ binding site [chemical binding]; other site 941193011861 substrate binding site [chemical binding]; other site 941193011862 Zn binding site [ion binding]; other site 941193011863 photoactive yellow protein; Region: photo_yellow; TIGR02373 941193011864 PAS domain; Region: PAS_9; pfam13426 941193011865 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 941193011866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193011867 Walker A motif; other site 941193011868 ATP binding site [chemical binding]; other site 941193011869 Walker B motif; other site 941193011870 arginine finger; other site 941193011871 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 941193011872 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 941193011873 Amidinotransferase; Region: Amidinotransf; cl12043 941193011874 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 941193011875 3-methyladenine DNA glycosylase [DNA replication, recombination, and repair]; Region: Tag; COG2818 941193011876 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 941193011877 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 941193011878 Ligand Binding Site [chemical binding]; other site 941193011879 DNA-J related protein; Region: DNAJ_related; pfam12339 941193011880 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 941193011881 HSP70 interaction site [polypeptide binding]; other site 941193011882 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 941193011883 hypothetical protein; Provisional; Region: PRK04860 941193011884 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 941193011885 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 941193011886 CoA-transferase family III; Region: CoA_transf_3; pfam02515 941193011887 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941193011888 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193011889 active site 941193011890 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 941193011891 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 941193011892 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 941193011893 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 941193011894 C-terminal domain interface [polypeptide binding]; other site 941193011895 GSH binding site (G-site) [chemical binding]; other site 941193011896 dimer interface [polypeptide binding]; other site 941193011897 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 941193011898 dimer interface [polypeptide binding]; other site 941193011899 N-terminal domain interface [polypeptide binding]; other site 941193011900 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 941193011901 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193011902 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 941193011903 dimerization interface [polypeptide binding]; other site 941193011904 substrate binding pocket [chemical binding]; other site 941193011905 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 941193011906 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 941193011907 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 941193011908 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941193011909 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193011910 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 941193011911 putative diguanylate cyclase; Provisional; Region: PRK09776 941193011912 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193011913 putative active site [active] 941193011914 heme pocket [chemical binding]; other site 941193011915 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193011916 putative active site [active] 941193011917 heme pocket [chemical binding]; other site 941193011918 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193011919 putative active site [active] 941193011920 heme pocket [chemical binding]; other site 941193011921 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193011922 metal binding site [ion binding]; metal-binding site 941193011923 active site 941193011924 I-site; other site 941193011925 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941193011926 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193011927 dimer interface [polypeptide binding]; other site 941193011928 phosphorylation site [posttranslational modification] 941193011929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193011930 ATP binding site [chemical binding]; other site 941193011931 G-X-G motif; other site 941193011932 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 941193011933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193011934 active site 941193011935 phosphorylation site [posttranslational modification] 941193011936 intermolecular recognition site; other site 941193011937 dimerization interface [polypeptide binding]; other site 941193011938 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193011939 DNA binding site [nucleotide binding] 941193011940 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 941193011941 Periplasmic nitrate reductase system, NapE component [Energy production and conversion]; Region: NapE; COG4459 941193011942 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 941193011943 Uncharacterized protein involved in formation of periplasmic nitrate reductase [Inorganic ion transport and metabolism]; Region: NapD; COG3062 941193011944 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 941193011945 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 941193011946 [4Fe-4S] binding site [ion binding]; other site 941193011947 molybdopterin cofactor binding site; other site 941193011948 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 941193011949 molybdopterin cofactor binding site; other site 941193011950 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 941193011951 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 941193011952 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 941193011953 Transglycosylase SLT domain; Region: SLT_2; pfam13406 941193011954 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 941193011955 N-acetyl-D-glucosamine binding site [chemical binding]; other site 941193011956 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 941193011957 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 941193011958 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 941193011959 Lipoxygenase; Region: Lipoxygenase; pfam00305 941193011960 Alginate lyase; Region: Alginate_lyase2; pfam08787 941193011961 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 941193011962 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 941193011963 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 941193011964 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 941193011965 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 941193011966 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 941193011967 putative ATP binding site [chemical binding]; other site 941193011968 putative substrate interface [chemical binding]; other site 941193011969 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 941193011970 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 941193011971 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 941193011972 active site 941193011973 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 941193011974 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 941193011975 metal binding site [ion binding]; metal-binding site 941193011976 dimer interface [polypeptide binding]; other site 941193011977 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 941193011978 Methyltransferase domain; Region: Methyltransf_11; pfam08241 941193011979 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 941193011980 DNA-binding site [nucleotide binding]; DNA binding site 941193011981 RNA-binding motif; other site 941193011982 sensor protein RstB; Provisional; Region: PRK10604 941193011983 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193011984 dimerization interface [polypeptide binding]; other site 941193011985 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193011986 dimer interface [polypeptide binding]; other site 941193011987 phosphorylation site [posttranslational modification] 941193011988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193011989 ATP binding site [chemical binding]; other site 941193011990 Mg2+ binding site [ion binding]; other site 941193011991 G-X-G motif; other site 941193011992 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 941193011993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193011994 active site 941193011995 phosphorylation site [posttranslational modification] 941193011996 intermolecular recognition site; other site 941193011997 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193011998 DNA binding site [nucleotide binding] 941193011999 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 941193012000 ATP cone domain; Region: ATP-cone; pfam03477 941193012001 ATP cone domain; Region: ATP-cone; pfam03477 941193012002 Class I ribonucleotide reductase; Region: RNR_I; cd01679 941193012003 active site 941193012004 dimer interface [polypeptide binding]; other site 941193012005 catalytic residues [active] 941193012006 effector binding site; other site 941193012007 R2 peptide binding site; other site 941193012008 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 941193012009 dimer interface [polypeptide binding]; other site 941193012010 putative radical transfer pathway; other site 941193012011 diiron center [ion binding]; other site 941193012012 tyrosyl radical; other site 941193012013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 941193012014 Prophage antirepressor [Transcription]; Region: COG3617 941193012015 BRO family, N-terminal domain; Region: Bro-N; smart01040 941193012016 S-type Pyocin; Region: Pyocin_S; pfam06958 941193012017 Uncharacterized protein conserved in bacteria (DUF2195); Region: DUF2195; cl02042 941193012018 Exotoxin A binding; Region: Exotox-A_bind; pfam09101 941193012019 Exotoxin A, targeting; Region: Exotox-A_target; pfam09102 941193012020 Mono-ADP-ribosylating toxins catalyze the transfer of ADP_ribose from NAD+ to eukaryotic Elongation Factor 2, halting protein synthesis. A single molecule of delivered toxin is sufficient to kill a cell. These toxins share mono-ADP-ribosylating activity...; Region: Dipth_tox_like; cd01436 941193012021 nad+ binding pocket [chemical binding]; other site 941193012022 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 941193012023 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 941193012024 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 941193012025 putative active site [active] 941193012026 metal binding site [ion binding]; metal-binding site 941193012027 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193012028 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193012029 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941193012030 dimerization interface [polypeptide binding]; other site 941193012031 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 941193012032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193012033 putative substrate translocation pore; other site 941193012034 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 941193012035 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 941193012036 transcriptional regulator protein; Region: phnR; TIGR03337 941193012037 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193012038 DNA-binding site [nucleotide binding]; DNA binding site 941193012039 UTRA domain; Region: UTRA; pfam07702 941193012040 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193012041 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193012042 LysR substrate binding domain; Region: LysR_substrate; pfam03466 941193012043 dimerization interface [polypeptide binding]; other site 941193012044 hypothetical protein; Provisional; Region: PRK11171 941193012045 Cupin domain; Region: Cupin_2; pfam07883 941193012046 Cupin domain; Region: Cupin_2; pfam07883 941193012047 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 941193012048 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 941193012049 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193012050 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193012051 LysR substrate binding domain; Region: LysR_substrate; pfam03466 941193012052 dimerization interface [polypeptide binding]; other site 941193012053 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 941193012054 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 941193012055 NAD(P) binding site [chemical binding]; other site 941193012056 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 941193012057 Autoinducer binding domain; Region: Autoind_bind; pfam03472 941193012058 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193012059 DNA binding residues [nucleotide binding] 941193012060 dimerization interface [polypeptide binding]; other site 941193012061 chaperone protein HchA; Provisional; Region: PRK04155 941193012062 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 941193012063 conserved cys residue [active] 941193012064 Protein of unknown function, DUF393; Region: DUF393; cl01136 941193012065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193012066 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 941193012067 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 941193012068 Ligand binding site; other site 941193012069 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 941193012070 dimer interface [polypeptide binding]; other site 941193012071 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941193012072 Mn binding site [ion binding]; other site 941193012073 K binding site [ion binding]; other site 941193012074 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193012075 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193012076 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 941193012077 putative effector binding pocket; other site 941193012078 putative dimerization interface [polypeptide binding]; other site 941193012079 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 941193012080 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 941193012081 active site 941193012082 catalytic tetrad [active] 941193012083 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 941193012084 NAD-dependent deacetylase; Provisional; Region: PRK00481 941193012085 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 941193012086 NAD+ binding site [chemical binding]; other site 941193012087 substrate binding site [chemical binding]; other site 941193012088 Zn binding site [ion binding]; other site 941193012089 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 941193012090 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941193012091 Zn2+ binding site [ion binding]; other site 941193012092 Mg2+ binding site [ion binding]; other site 941193012093 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 941193012094 Protein of unknown function (DUF2025); Region: DUF2025; pfam09634 941193012095 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 941193012096 active site 941193012097 catalytic residues [active] 941193012098 metal binding site [ion binding]; metal-binding site 941193012099 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 941193012100 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 941193012101 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193012102 dimerization interface [polypeptide binding]; other site 941193012103 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193012104 metal binding site [ion binding]; metal-binding site 941193012105 active site 941193012106 I-site; other site 941193012107 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 941193012108 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 941193012109 ligand binding site [chemical binding]; other site 941193012110 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 941193012111 S1 domain; Region: S1_2; pfam13509 941193012112 S1 domain; Region: S1_2; pfam13509 941193012113 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 941193012114 Sulfatase; Region: Sulfatase; pfam00884 941193012115 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 941193012116 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 941193012117 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941193012118 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193012119 Walker A/P-loop; other site 941193012120 ATP binding site [chemical binding]; other site 941193012121 Q-loop/lid; other site 941193012122 ABC transporter signature motif; other site 941193012123 Walker B; other site 941193012124 D-loop; other site 941193012125 H-loop/switch region; other site 941193012126 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 941193012127 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 941193012128 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 941193012129 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 941193012130 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941193012131 RNA binding surface [nucleotide binding]; other site 941193012132 Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555 941193012133 active site 941193012134 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 941193012135 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941193012136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193012137 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193012138 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193012139 metal binding site [ion binding]; metal-binding site 941193012140 active site 941193012141 I-site; other site 941193012142 conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001 941193012143 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 941193012144 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 941193012145 flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688 941193012146 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 941193012147 Walker A motif/ATP binding site; other site 941193012148 Walker B motif; other site 941193012149 flagellar assembly protein H; Validated; Region: fliH; PRK05687 941193012150 Flagellar assembly protein FliH; Region: FliH; pfam02108 941193012151 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 941193012152 MgtE intracellular N domain; Region: MgtE_N; smart00924 941193012153 FliG C-terminal domain; Region: FliG_C; pfam01706 941193012154 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 941193012155 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 941193012156 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 941193012157 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 941193012158 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 941193012159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193012160 active site 941193012161 phosphorylation site [posttranslational modification] 941193012162 intermolecular recognition site; other site 941193012163 dimerization interface [polypeptide binding]; other site 941193012164 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193012165 Walker A motif; other site 941193012166 ATP binding site [chemical binding]; other site 941193012167 Walker B motif; other site 941193012168 arginine finger; other site 941193012169 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941193012170 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941193012171 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193012172 putative active site [active] 941193012173 heme pocket [chemical binding]; other site 941193012174 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193012175 dimer interface [polypeptide binding]; other site 941193012176 phosphorylation site [posttranslational modification] 941193012177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193012178 ATP binding site [chemical binding]; other site 941193012179 Mg2+ binding site [ion binding]; other site 941193012180 G-X-G motif; other site 941193012181 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 941193012182 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 941193012183 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193012184 Walker A motif; other site 941193012185 ATP binding site [chemical binding]; other site 941193012186 Walker B motif; other site 941193012187 arginine finger; other site 941193012188 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941193012189 flagellar protein FliS; Validated; Region: fliS; PRK05685 941193012190 Flagellar protein FliS; Region: FliS; cl00654 941193012191 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 941193012192 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 941193012193 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 941193012194 FlaG protein; Region: FlaG; pfam03646 941193012195 flagellin; Reviewed; Region: PRK08869 941193012196 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 941193012197 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 941193012198 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 941193012199 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 941193012200 active site 941193012201 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 941193012202 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 941193012203 active site 941193012204 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 941193012205 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 941193012206 active site 941193012207 catalytic residues [active] 941193012208 metal binding site [ion binding]; metal-binding site 941193012209 Methyltransferase domain; Region: Methyltransf_23; pfam13489 941193012210 Methyltransferase domain; Region: Methyltransf_12; pfam08242 941193012211 S-adenosylmethionine binding site [chemical binding]; other site 941193012212 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 941193012213 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 941193012214 Ligand binding site; other site 941193012215 oligomer interface; other site 941193012216 WavE lipopolysaccharide synthesis; Region: WavE; pfam07507 941193012217 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 941193012218 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 941193012219 putative trimer interface [polypeptide binding]; other site 941193012220 putative CoA binding site [chemical binding]; other site 941193012221 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 941193012222 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 941193012223 [2Fe-2S] cluster binding site [ion binding]; other site 941193012224 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 941193012225 alpha subunit interface [polypeptide binding]; other site 941193012226 active site 941193012227 substrate binding site [chemical binding]; other site 941193012228 Fe binding site [ion binding]; other site 941193012229 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 941193012230 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 941193012231 putative trimer interface [polypeptide binding]; other site 941193012232 putative CoA binding site [chemical binding]; other site 941193012233 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 941193012234 classical (c) SDRs; Region: SDR_c; cd05233 941193012235 NAD(P) binding site [chemical binding]; other site 941193012236 active site 941193012237 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 941193012238 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 941193012239 dimer interface [polypeptide binding]; other site 941193012240 active site 941193012241 CoA binding pocket [chemical binding]; other site 941193012242 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 941193012243 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 941193012244 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 941193012245 inhibitor-cofactor binding pocket; inhibition site 941193012246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193012247 catalytic residue [active] 941193012248 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 941193012249 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 941193012250 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 941193012251 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683 941193012252 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 941193012253 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 941193012254 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 941193012255 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 941193012256 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 941193012257 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 941193012258 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 941193012259 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 941193012260 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 941193012261 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 941193012262 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 941193012263 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 941193012264 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 941193012265 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 941193012266 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 941193012267 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 941193012268 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 941193012269 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 941193012270 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 941193012271 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 941193012272 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 941193012273 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 941193012274 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 941193012275 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 941193012276 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 941193012277 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 941193012278 Uncharacterized small conserved protein [Function unknown]; Region: COG5626 941193012279 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 941193012280 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 941193012281 dimerization interface [polypeptide binding]; other site 941193012282 ligand binding site [chemical binding]; other site 941193012283 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941193012284 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 941193012285 TM-ABC transporter signature motif; other site 941193012286 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 941193012287 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 941193012288 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 941193012289 TM-ABC transporter signature motif; other site 941193012290 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 941193012291 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 941193012292 Walker A/P-loop; other site 941193012293 ATP binding site [chemical binding]; other site 941193012294 Q-loop/lid; other site 941193012295 ABC transporter signature motif; other site 941193012296 Walker B; other site 941193012297 D-loop; other site 941193012298 H-loop/switch region; other site 941193012299 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 941193012300 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 941193012301 Walker A/P-loop; other site 941193012302 ATP binding site [chemical binding]; other site 941193012303 Q-loop/lid; other site 941193012304 ABC transporter signature motif; other site 941193012305 Walker B; other site 941193012306 D-loop; other site 941193012307 H-loop/switch region; other site 941193012308 NMDA receptor-regulated protein 1; Region: NARP1; pfam12569 941193012309 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 941193012310 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 941193012311 ATP binding site [chemical binding]; other site 941193012312 Mg2+ binding site [ion binding]; other site 941193012313 G-X-G motif; other site 941193012314 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193012315 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193012316 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941193012317 putative effector binding pocket; other site 941193012318 dimerization interface [polypeptide binding]; other site 941193012319 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 941193012320 putative NAD(P) binding site [chemical binding]; other site 941193012321 homodimer interface [polypeptide binding]; other site 941193012322 Uncharacterized conserved protein [Function unknown]; Region: COG3189 941193012323 Predicted membrane protein [Function unknown]; Region: COG3650 941193012324 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 941193012325 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 941193012326 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 941193012327 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941193012328 catalytic residue [active] 941193012329 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 941193012330 EamA-like transporter family; Region: EamA; pfam00892 941193012331 EamA-like transporter family; Region: EamA; pfam00892 941193012332 Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320 941193012333 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 941193012334 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 941193012335 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 941193012336 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 941193012337 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 941193012338 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 941193012339 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 941193012340 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 941193012341 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 941193012342 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 941193012343 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 941193012344 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 941193012345 fructuronate transporter; Provisional; Region: PRK10034; cl15264 941193012346 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 941193012347 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 941193012348 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 941193012349 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 941193012350 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 941193012351 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 941193012352 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 941193012353 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 941193012354 ligand binding site [chemical binding]; other site 941193012355 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 941193012356 Beta-lactamase; Region: Beta-lactamase; pfam00144 941193012357 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 941193012358 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 941193012359 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 941193012360 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 941193012361 Predicted integral membrane protein [Function unknown]; Region: COG5615 941193012362 Predicted membrane protein [Function unknown]; Region: COG3776 941193012363 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 941193012364 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 941193012365 ligand binding site [chemical binding]; other site 941193012366 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941193012367 SEC-C motif; Region: SEC-C; pfam02810 941193012368 hypothetical protein; Provisional; Region: PRK04233 941193012369 Predicted membrane protein [Function unknown]; Region: COG2860 941193012370 UPF0126 domain; Region: UPF0126; pfam03458 941193012371 UPF0126 domain; Region: UPF0126; pfam03458 941193012372 LEA14-like dessication related protein [Defense mechanisms]; Region: COG5608 941193012373 Water Stress and Hypersensitive response; Region: WHy; smart00769 941193012374 SEC-C motif; Region: SEC-C; pfam02810 941193012375 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 941193012376 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 941193012377 C-terminal domain interface [polypeptide binding]; other site 941193012378 GSH binding site (G-site) [chemical binding]; other site 941193012379 dimer interface [polypeptide binding]; other site 941193012380 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 941193012381 N-terminal domain interface [polypeptide binding]; other site 941193012382 putative dimer interface [polypeptide binding]; other site 941193012383 active site 941193012384 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 941193012385 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 941193012386 active site 941193012387 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 941193012388 RmuC family; Region: RmuC; pfam02646 941193012389 RES domain; Region: RES; smart00953 941193012390 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941193012391 salt bridge; other site 941193012392 sequence-specific DNA binding site [nucleotide binding]; other site 941193012393 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 941193012394 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 941193012395 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 941193012396 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 941193012397 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 941193012398 tetrameric interface [polypeptide binding]; other site 941193012399 NAD binding site [chemical binding]; other site 941193012400 catalytic residues [active] 941193012401 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 941193012402 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 941193012403 outer membrane porin, OprD family; Region: OprD; pfam03573 941193012404 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 941193012405 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 941193012406 FMN binding site [chemical binding]; other site 941193012407 substrate binding site [chemical binding]; other site 941193012408 putative catalytic residue [active] 941193012409 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 941193012410 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193012411 NAD(P) binding site [chemical binding]; other site 941193012412 active site 941193012413 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 941193012414 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193012415 active site 941193012416 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 941193012417 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941193012418 substrate binding site [chemical binding]; other site 941193012419 oxyanion hole (OAH) forming residues; other site 941193012420 trimer interface [polypeptide binding]; other site 941193012421 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 941193012422 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193012423 active site 941193012424 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 941193012425 CoenzymeA binding site [chemical binding]; other site 941193012426 subunit interaction site [polypeptide binding]; other site 941193012427 PHB binding site; other site 941193012428 benzoate transport; Region: 2A0115; TIGR00895 941193012429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193012430 putative substrate translocation pore; other site 941193012431 enoyl-CoA hydratase; Region: PLN02864 941193012432 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 941193012433 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 941193012434 dimer interaction site [polypeptide binding]; other site 941193012435 substrate-binding tunnel; other site 941193012436 active site 941193012437 catalytic site [active] 941193012438 substrate binding site [chemical binding]; other site 941193012439 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 941193012440 CoA binding domain; Region: CoA_binding_2; pfam13380 941193012441 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 941193012442 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 941193012443 thiolase; Provisional; Region: PRK06158 941193012444 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 941193012445 active site 941193012446 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 941193012447 DUF35 OB-fold domain; Region: DUF35; pfam01796 941193012448 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 941193012449 Transcriptional regulator [Transcription]; Region: IclR; COG1414 941193012450 Bacterial transcriptional regulator; Region: IclR; pfam01614 941193012451 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 941193012452 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 941193012453 active site 941193012454 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 941193012455 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 941193012456 ATP binding site [chemical binding]; other site 941193012457 active site 941193012458 substrate binding site [chemical binding]; other site 941193012459 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 941193012460 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 941193012461 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 941193012462 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 941193012463 dihydrodipicolinate synthase; Region: dapA; TIGR00674 941193012464 dimer interface [polypeptide binding]; other site 941193012465 active site 941193012466 catalytic residue [active] 941193012467 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 941193012468 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 941193012469 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 941193012470 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 941193012471 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 941193012472 catalytic triad [active] 941193012473 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 941193012474 Domain of unknown function DUF20; Region: UPF0118; pfam01594 941193012475 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 941193012476 CPxP motif; other site 941193012477 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 941193012478 Peptidase family M48; Region: Peptidase_M48; cl12018 941193012479 quinolinate synthetase; Provisional; Region: PRK09375 941193012480 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193012481 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193012482 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941193012483 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 941193012484 Glutamine amidotransferase class-I; Region: GATase; pfam00117 941193012485 glutamine binding [chemical binding]; other site 941193012486 catalytic triad [active] 941193012487 anthranilate synthase component I; Provisional; Region: PRK13564 941193012488 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 941193012489 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 941193012490 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941193012491 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 941193012492 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 941193012493 dimer interface [polypeptide binding]; other site 941193012494 active site 941193012495 CoA binding pocket [chemical binding]; other site 941193012496 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 941193012497 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 941193012498 active site 941193012499 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 941193012500 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 941193012501 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 941193012502 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 941193012503 dimer interface [polypeptide binding]; other site 941193012504 acyl-activating enzyme (AAE) consensus motif; other site 941193012505 putative active site [active] 941193012506 putative AMP binding site [chemical binding]; other site 941193012507 putative CoA binding site [chemical binding]; other site 941193012508 chemical substrate binding site [chemical binding]; other site 941193012509 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 941193012510 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 941193012511 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 941193012512 DNA binding site [nucleotide binding] 941193012513 active site 941193012514 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 941193012515 PapC N-terminal domain; Region: PapC_N; pfam13954 941193012516 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 941193012517 PapC C-terminal domain; Region: PapC_C; pfam13953 941193012518 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 941193012519 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 941193012520 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 941193012521 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 941193012522 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 941193012523 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 941193012524 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 941193012525 nudix motif; other site 941193012526 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 941193012527 active site 941193012528 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 941193012529 Ligand Binding Site [chemical binding]; other site 941193012530 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 941193012531 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941193012532 FeS/SAM binding site; other site 941193012533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 941193012534 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941193012535 binding surface 941193012536 TPR motif; other site 941193012537 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 941193012538 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 941193012539 ligand binding site [chemical binding]; other site 941193012540 translocation protein TolB; Provisional; Region: tolB; PRK00178 941193012541 TolB amino-terminal domain; Region: TolB_N; pfam04052 941193012542 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 941193012543 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 941193012544 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 941193012545 TolA protein; Region: tolA_full; TIGR02794 941193012546 TolA protein; Region: tolA_full; TIGR02794 941193012547 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 941193012548 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 941193012549 TolR protein; Region: tolR; TIGR02801 941193012550 TolQ protein; Region: tolQ; TIGR02796 941193012551 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 941193012552 active site 941193012553 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 941193012554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193012555 Walker A motif; other site 941193012556 ATP binding site [chemical binding]; other site 941193012557 Walker B motif; other site 941193012558 arginine finger; other site 941193012559 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 941193012560 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 941193012561 RuvA N terminal domain; Region: RuvA_N; pfam01330 941193012562 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 941193012563 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 941193012564 active site 941193012565 putative DNA-binding cleft [nucleotide binding]; other site 941193012566 dimer interface [polypeptide binding]; other site 941193012567 hypothetical protein; Validated; Region: PRK00110 941193012568 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 941193012569 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 941193012570 dimer interface [polypeptide binding]; other site 941193012571 anticodon binding site; other site 941193012572 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 941193012573 homodimer interface [polypeptide binding]; other site 941193012574 motif 1; other site 941193012575 active site 941193012576 motif 2; other site 941193012577 GAD domain; Region: GAD; pfam02938 941193012578 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 941193012579 active site 941193012580 motif 3; other site 941193012581 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 941193012582 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 941193012583 dimerization interface [polypeptide binding]; other site 941193012584 DPS ferroxidase diiron center [ion binding]; other site 941193012585 ion pore; other site 941193012586 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 941193012587 DNA-binding site [nucleotide binding]; DNA binding site 941193012588 RNA-binding motif; other site 941193012589 hypothetical protein; Provisional; Region: PRK00295 941193012590 HIT domain; Region: HIT; pfam01230 941193012591 nucleotide binding site/active site [active] 941193012592 HIT family signature motif; other site 941193012593 catalytic residue [active] 941193012594 outer membrane porin, OprD family; Region: OprD; pfam03573 941193012595 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 941193012596 CoenzymeA binding site [chemical binding]; other site 941193012597 subunit interaction site [polypeptide binding]; other site 941193012598 PHB binding site; other site 941193012599 prolyl-tRNA synthetase; Provisional; Region: PRK09194 941193012600 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 941193012601 dimer interface [polypeptide binding]; other site 941193012602 motif 1; other site 941193012603 active site 941193012604 motif 2; other site 941193012605 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 941193012606 putative deacylase active site [active] 941193012607 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 941193012608 active site 941193012609 motif 3; other site 941193012610 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 941193012611 anticodon binding site; other site 941193012612 acylphosphatase; Provisional; Region: PRK14442 941193012613 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 941193012614 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 941193012615 catalytic residues [active] 941193012616 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 941193012617 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 941193012618 ArsC family; Region: ArsC; pfam03960 941193012619 catalytic residues [active] 941193012620 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 941193012621 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941193012622 Predicted membrane protein [Function unknown]; Region: COG3308 941193012623 DNA replication initiation factor; Validated; Region: PRK05642 941193012624 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 941193012625 Walker A motif; other site 941193012626 ATP binding site [chemical binding]; other site 941193012627 Walker B motif; other site 941193012628 arginine finger; other site 941193012629 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 941193012630 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 941193012631 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 941193012632 dimerization interface [polypeptide binding]; other site 941193012633 putative ATP binding site [chemical binding]; other site 941193012634 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 941193012635 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 941193012636 active site 941193012637 substrate binding site [chemical binding]; other site 941193012638 cosubstrate binding site; other site 941193012639 catalytic site [active] 941193012640 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 941193012641 Transcriptional regulators [Transcription]; Region: MarR; COG1846 941193012642 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 941193012643 MarR family; Region: MarR_2; cl17246 941193012644 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 941193012645 Domain of unknown function (DUF2024); Region: DUF2024; pfam09630 941193012646 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 941193012647 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 941193012648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 941193012649 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 941193012650 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 941193012651 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 941193012652 homodimer interface [polypeptide binding]; other site 941193012653 metal binding site [ion binding]; metal-binding site 941193012654 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 941193012655 homodimer interface [polypeptide binding]; other site 941193012656 active site 941193012657 putative chemical substrate binding site [chemical binding]; other site 941193012658 metal binding site [ion binding]; metal-binding site 941193012659 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 941193012660 HD domain; Region: HD_4; pfam13328 941193012661 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 941193012662 synthetase active site [active] 941193012663 NTP binding site [chemical binding]; other site 941193012664 metal binding site [ion binding]; metal-binding site 941193012665 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 941193012666 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 941193012667 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 941193012668 TRAM domain; Region: TRAM; pfam01938 941193012669 cysteine synthase B; Region: cysM; TIGR01138 941193012670 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 941193012671 dimer interface [polypeptide binding]; other site 941193012672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193012673 catalytic residue [active] 941193012674 outer membrane receptor FepA; Provisional; Region: PRK13528 941193012675 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193012676 N-terminal plug; other site 941193012677 ligand-binding site [chemical binding]; other site 941193012678 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941193012679 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193012680 dimerization interface [polypeptide binding]; other site 941193012681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193012682 dimer interface [polypeptide binding]; other site 941193012683 phosphorylation site [posttranslational modification] 941193012684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193012685 ATP binding site [chemical binding]; other site 941193012686 G-X-G motif; other site 941193012687 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941193012688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193012689 active site 941193012690 phosphorylation site [posttranslational modification] 941193012691 intermolecular recognition site; other site 941193012692 dimerization interface [polypeptide binding]; other site 941193012693 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193012694 DNA binding site [nucleotide binding] 941193012695 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 941193012696 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193012697 dimerization interface [polypeptide binding]; other site 941193012698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193012699 dimer interface [polypeptide binding]; other site 941193012700 phosphorylation site [posttranslational modification] 941193012701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193012702 ATP binding site [chemical binding]; other site 941193012703 Mg2+ binding site [ion binding]; other site 941193012704 G-X-G motif; other site 941193012705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193012706 active site 941193012707 phosphorylation site [posttranslational modification] 941193012708 intermolecular recognition site; other site 941193012709 dimerization interface [polypeptide binding]; other site 941193012710 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 941193012711 putative binding surface; other site 941193012712 active site 941193012713 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 941193012714 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 941193012715 putative ligand binding site [chemical binding]; other site 941193012716 putative NAD binding site [chemical binding]; other site 941193012717 catalytic site [active] 941193012718 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 941193012719 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 941193012720 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 941193012721 Sulfatase; Region: Sulfatase; cl17466 941193012722 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 941193012723 active site 941193012724 DNA polymerase IV; Validated; Region: PRK02406 941193012725 DNA binding site [nucleotide binding] 941193012726 Replication protein A C terminal; Region: RPA_C; pfam08784 941193012727 Predicted integral membrane protein [Function unknown]; Region: COG0392 941193012728 Uncharacterized conserved protein [Function unknown]; Region: COG2898 941193012729 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 941193012730 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 941193012731 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 941193012732 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 941193012733 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 941193012734 potassium uptake protein; Region: kup; TIGR00794 941193012735 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 941193012736 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 941193012737 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941193012738 FeS/SAM binding site; other site 941193012739 TRAM domain; Region: TRAM; pfam01938 941193012740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 941193012741 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 941193012742 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 941193012743 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 941193012744 MgtE intracellular N domain; Region: MgtE_N; smart00924 941193012745 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 941193012746 Divalent cation transporter; Region: MgtE; pfam01769 941193012747 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 941193012748 Protein of unknown function (DUF754); Region: DUF754; pfam05449 941193012749 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 941193012750 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941193012751 non-specific DNA binding site [nucleotide binding]; other site 941193012752 Predicted transcriptional regulator [Transcription]; Region: COG2932 941193012753 salt bridge; other site 941193012754 sequence-specific DNA binding site [nucleotide binding]; other site 941193012755 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 941193012756 Catalytic site [active] 941193012757 carbon storage regulator; Provisional; Region: PRK01712 941193012758 aspartate kinase; Reviewed; Region: PRK06635 941193012759 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 941193012760 putative nucleotide binding site [chemical binding]; other site 941193012761 putative catalytic residues [active] 941193012762 putative Mg ion binding site [ion binding]; other site 941193012763 putative aspartate binding site [chemical binding]; other site 941193012764 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 941193012765 putative allosteric regulatory site; other site 941193012766 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 941193012767 putative allosteric regulatory residue; other site 941193012768 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 941193012769 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 941193012770 motif 1; other site 941193012771 active site 941193012772 motif 2; other site 941193012773 motif 3; other site 941193012774 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 941193012775 DHHA1 domain; Region: DHHA1; pfam02272 941193012776 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 941193012777 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 941193012778 tetramer interface [polypeptide binding]; other site 941193012779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193012780 catalytic residue [active] 941193012781 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 941193012782 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 941193012783 putative active site [active] 941193012784 Zn binding site [ion binding]; other site 941193012785 succinylarginine dihydrolase; Provisional; Region: PRK13281 941193012786 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 941193012787 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 941193012788 NAD(P) binding site [chemical binding]; other site 941193012789 catalytic residues [active] 941193012790 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 941193012791 arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244 941193012792 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 941193012793 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 941193012794 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 941193012795 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941193012796 inhibitor-cofactor binding pocket; inhibition site 941193012797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193012798 catalytic residue [active] 941193012799 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 941193012800 conserved cys residue [active] 941193012801 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193012802 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941193012803 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193012804 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 941193012805 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 941193012806 Walker A/P-loop; other site 941193012807 ATP binding site [chemical binding]; other site 941193012808 Q-loop/lid; other site 941193012809 ABC transporter signature motif; other site 941193012810 Walker B; other site 941193012811 D-loop; other site 941193012812 H-loop/switch region; other site 941193012813 Predicted deacylase [General function prediction only]; Region: COG3608 941193012814 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 941193012815 active site 941193012816 Zn binding site [ion binding]; other site 941193012817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193012818 dimer interface [polypeptide binding]; other site 941193012819 conserved gate region; other site 941193012820 putative PBP binding loops; other site 941193012821 ABC-ATPase subunit interface; other site 941193012822 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 941193012823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193012824 dimer interface [polypeptide binding]; other site 941193012825 conserved gate region; other site 941193012826 putative PBP binding loops; other site 941193012827 ABC-ATPase subunit interface; other site 941193012828 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 941193012829 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193012830 substrate binding pocket [chemical binding]; other site 941193012831 membrane-bound complex binding site; other site 941193012832 hinge residues; other site 941193012833 acetyl-CoA synthetase; Provisional; Region: PRK00174 941193012834 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 941193012835 active site 941193012836 CoA binding site [chemical binding]; other site 941193012837 acyl-activating enzyme (AAE) consensus motif; other site 941193012838 AMP binding site [chemical binding]; other site 941193012839 acetate binding site [chemical binding]; other site 941193012840 DctM-like transporters; Region: DctM; pfam06808 941193012841 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 941193012842 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 941193012843 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 941193012844 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 941193012845 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 941193012846 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 941193012847 CoA-transferase family III; Region: CoA_transf_3; pfam02515 941193012848 MmgE/PrpD family; Region: MmgE_PrpD; pfam03972 941193012849 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 941193012850 dimer interface [polypeptide binding]; other site 941193012851 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941193012852 metal binding site [ion binding]; metal-binding site 941193012853 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941193012854 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193012855 active site 941193012856 Uncharacterized conserved protein [Function unknown]; Region: COG3777 941193012857 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 941193012858 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 941193012859 active site 2 [active] 941193012860 active site 1 [active] 941193012861 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193012862 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193012863 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 941193012864 putative dimerization interface [polypeptide binding]; other site 941193012865 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193012866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193012867 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941193012868 putative effector binding pocket; other site 941193012869 dimerization interface [polypeptide binding]; other site 941193012870 Fusaric acid resistance protein family; Region: FUSC; pfam04632 941193012871 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 941193012872 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 941193012873 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 941193012874 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 941193012875 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 941193012876 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193012877 putative active site [active] 941193012878 heme pocket [chemical binding]; other site 941193012879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193012880 Walker A motif; other site 941193012881 ATP binding site [chemical binding]; other site 941193012882 Walker B motif; other site 941193012883 arginine finger; other site 941193012884 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 941193012885 cofactor binding site; other site 941193012886 metal binding site [ion binding]; metal-binding site 941193012887 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 941193012888 aromatic arch; other site 941193012889 DCoH dimer interaction site [polypeptide binding]; other site 941193012890 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 941193012891 DCoH tetramer interaction site [polypeptide binding]; other site 941193012892 substrate binding site [chemical binding]; other site 941193012893 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 941193012894 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941193012895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193012896 homodimer interface [polypeptide binding]; other site 941193012897 catalytic residue [active] 941193012898 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 941193012899 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 941193012900 hypothetical protein; Provisional; Region: PRK09256 941193012901 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 941193012902 lysozyme inhibitor; Provisional; Region: PRK13792 941193012903 Predicted periplasmic protein [General function prediction only]; Region: COG3895 941193012904 aromatic amino acid transporter; Provisional; Region: PRK10238 941193012905 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 941193012906 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 941193012907 dimer interface [polypeptide binding]; other site 941193012908 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 941193012909 active site 941193012910 Fe binding site [ion binding]; other site 941193012911 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 941193012912 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941193012913 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193012914 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193012915 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 941193012916 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 941193012917 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 941193012918 putative NAD(P) binding site [chemical binding]; other site 941193012919 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 941193012920 PAS domain S-box; Region: sensory_box; TIGR00229 941193012921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193012922 putative active site [active] 941193012923 heme pocket [chemical binding]; other site 941193012924 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193012925 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193012926 metal binding site [ion binding]; metal-binding site 941193012927 active site 941193012928 I-site; other site 941193012929 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941193012930 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941193012931 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941193012932 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193012933 Walker A/P-loop; other site 941193012934 ATP binding site [chemical binding]; other site 941193012935 Q-loop/lid; other site 941193012936 ABC transporter signature motif; other site 941193012937 Walker B; other site 941193012938 D-loop; other site 941193012939 H-loop/switch region; other site 941193012940 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 941193012941 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 941193012942 catalytic residues [active] 941193012943 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 941193012944 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 941193012945 active site residue [active] 941193012946 BolA-like protein; Region: BolA; cl00386 941193012947 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 941193012948 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 941193012949 fumarate hydratase; Provisional; Region: PRK12425 941193012950 Class II fumarases; Region: Fumarase_classII; cd01362 941193012951 active site 941193012952 tetramer interface [polypeptide binding]; other site 941193012953 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 941193012954 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941193012955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 941193012956 Chitin binding domain; Region: Chitin_bind_3; pfam03067 941193012957 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 941193012958 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 941193012959 tetramer interface [polypeptide binding]; other site 941193012960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193012961 catalytic residue [active] 941193012962 MAPEG family; Region: MAPEG; pfam01124 941193012963 thioredoxin reductase; Provisional; Region: PRK10262 941193012964 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941193012965 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941193012966 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 941193012967 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 941193012968 dimer interface [polypeptide binding]; other site 941193012969 decamer (pentamer of dimers) interface [polypeptide binding]; other site 941193012970 catalytic triad [active] 941193012971 peroxidatic and resolving cysteines [active] 941193012972 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322 941193012973 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193012974 dimerization interface [polypeptide binding]; other site 941193012975 PAS domain S-box; Region: sensory_box; TIGR00229 941193012976 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193012977 putative active site [active] 941193012978 heme pocket [chemical binding]; other site 941193012979 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193012980 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193012981 metal binding site [ion binding]; metal-binding site 941193012982 active site 941193012983 I-site; other site 941193012984 putative sulfate transport protein CysZ; Validated; Region: PRK04949 941193012985 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 941193012986 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 941193012987 Phosphoesterase family; Region: Phosphoesterase; pfam04185 941193012988 Domain of unknown function (DUF756); Region: DUF756; pfam05506 941193012989 Domain of unknown function (DUF756); Region: DUF756; pfam05506 941193012990 phospholipase C accessory protein PlcR; Region: plc_access_R; TIGR03398 941193012991 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941193012992 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 941193012993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 941193012994 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 941193012995 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 941193012996 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 941193012997 putative active site [active] 941193012998 putative FMN binding site [chemical binding]; other site 941193012999 putative substrate binding site [chemical binding]; other site 941193013000 putative catalytic residue [active] 941193013001 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193013002 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193013003 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 941193013004 catalytic residues [active] 941193013005 dimer interface [polypeptide binding]; other site 941193013006 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 941193013007 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 941193013008 Protein of unknown function (DUF3565); Region: DUF3565; pfam12088 941193013009 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 941193013010 propionate/acetate kinase; Provisional; Region: PRK12379 941193013011 phosphate acetyltransferase; Reviewed; Region: PRK05632 941193013012 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941193013013 DRTGG domain; Region: DRTGG; pfam07085 941193013014 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 941193013015 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 941193013016 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 941193013017 putative acyl-acceptor binding pocket; other site 941193013018 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 941193013019 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 941193013020 ligand binding site [chemical binding]; other site 941193013021 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 941193013022 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 941193013023 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941193013024 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193013025 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 941193013026 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 941193013027 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 941193013028 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 941193013029 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 941193013030 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193013031 integrase; Provisional; Region: int; PHA02601 941193013032 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 941193013033 Helix-turn-helix domain; Region: HTH_37; pfam13744 941193013034 non-specific DNA binding site [nucleotide binding]; other site 941193013035 salt bridge; other site 941193013036 sequence-specific DNA binding site [nucleotide binding]; other site 941193013037 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 941193013038 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941193013039 putative metal binding site [ion binding]; other site 941193013040 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193013041 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193013042 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 941193013043 putative dimerization interface [polypeptide binding]; other site 941193013044 cell density-dependent motility repressor; Provisional; Region: PRK10082 941193013045 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193013046 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941193013047 dimerization interface [polypeptide binding]; other site 941193013048 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 941193013049 homotrimer interaction site [polypeptide binding]; other site 941193013050 putative active site [active] 941193013051 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 941193013052 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941193013053 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941193013054 catalytic residue [active] 941193013055 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 941193013056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193013057 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941193013058 putative substrate translocation pore; other site 941193013059 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 941193013060 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941193013061 motif II; other site 941193013062 manganese transport protein MntH; Reviewed; Region: PRK00701 941193013063 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 941193013064 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 941193013065 putative hydrophobic ligand binding site [chemical binding]; other site 941193013066 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 941193013067 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 941193013068 amidase catalytic site [active] 941193013069 Zn binding residues [ion binding]; other site 941193013070 substrate binding site [chemical binding]; other site 941193013071 Predicted membrane protein [Function unknown]; Region: COG4270 941193013072 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 941193013073 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 941193013074 active site 941193013075 catalytic tetrad [active] 941193013076 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 941193013077 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941193013078 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 941193013079 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 941193013080 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 941193013081 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 941193013082 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 941193013083 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941193013084 ATP binding site [chemical binding]; other site 941193013085 putative Mg++ binding site [ion binding]; other site 941193013086 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941193013087 nucleotide binding region [chemical binding]; other site 941193013088 ATP-binding site [chemical binding]; other site 941193013089 Methyltransferase domain; Region: Methyltransf_31; pfam13847 941193013090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193013091 S-adenosylmethionine binding site [chemical binding]; other site 941193013092 Transcriptional regulators [Transcription]; Region: GntR; COG1802 941193013093 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193013094 DNA-binding site [nucleotide binding]; DNA binding site 941193013095 FCD domain; Region: FCD; pfam07729 941193013096 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 941193013097 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 941193013098 tetramer interface [polypeptide binding]; other site 941193013099 active site 941193013100 Mg2+/Mn2+ binding site [ion binding]; other site 941193013101 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 941193013102 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 941193013103 dimer interface [polypeptide binding]; other site 941193013104 active site 941193013105 citrylCoA binding site [chemical binding]; other site 941193013106 oxalacetate/citrate binding site [chemical binding]; other site 941193013107 coenzyme A binding site [chemical binding]; other site 941193013108 catalytic triad [active] 941193013109 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 941193013110 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 941193013111 substrate binding site [chemical binding]; other site 941193013112 ligand binding site [chemical binding]; other site 941193013113 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 941193013114 substrate binding site [chemical binding]; other site 941193013115 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 941193013116 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 941193013117 2-methylcitrate dehydratase; Region: prpD; TIGR02330 941193013118 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 941193013119 Helix-turn-helix domain; Region: HTH_18; pfam12833 941193013120 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193013121 Predicted permeases [General function prediction only]; Region: COG0730 941193013122 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 941193013123 Spore germination protein; Region: Spore_permease; cl17796 941193013124 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 941193013125 Transglycosylase; Region: Transgly; cl17702 941193013126 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 941193013127 Predicted ATPase [General function prediction only]; Region: COG4637 941193013128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193013129 Walker A/P-loop; other site 941193013130 ATP binding site [chemical binding]; other site 941193013131 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 941193013132 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 941193013133 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941193013134 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 941193013135 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193013136 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193013137 dimerization interface [polypeptide binding]; other site 941193013138 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 941193013139 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 941193013140 Na binding site [ion binding]; other site 941193013141 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 941193013142 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 941193013143 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 941193013144 Glutamate binding site [chemical binding]; other site 941193013145 NAD binding site [chemical binding]; other site 941193013146 catalytic residues [active] 941193013147 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 941193013148 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193013149 N-terminal plug; other site 941193013150 ligand-binding site [chemical binding]; other site 941193013151 Cupin domain; Region: Cupin_2; cl17218 941193013152 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941193013153 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193013154 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193013155 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 941193013156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193013157 Walker A motif; other site 941193013158 ATP binding site [chemical binding]; other site 941193013159 Walker B motif; other site 941193013160 arginine finger; other site 941193013161 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 941193013162 Predicted secreted protein [Function unknown]; Region: COG5513 941193013163 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 941193013164 Methyltransferase domain; Region: Methyltransf_31; pfam13847 941193013165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193013166 S-adenosylmethionine binding site [chemical binding]; other site 941193013167 Methyltransferase domain; Region: Methyltransf_31; pfam13847 941193013168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193013169 S-adenosylmethionine binding site [chemical binding]; other site 941193013170 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 941193013171 active site 941193013172 hydrophilic channel; other site 941193013173 dimerization interface [polypeptide binding]; other site 941193013174 catalytic residues [active] 941193013175 active site lid [active] 941193013176 Recombination protein O N terminal; Region: RecO_N; pfam11967 941193013177 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 941193013178 Recombination protein O C terminal; Region: RecO_C; pfam02565 941193013179 GTPase Era; Reviewed; Region: era; PRK00089 941193013180 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 941193013181 G1 box; other site 941193013182 GTP/Mg2+ binding site [chemical binding]; other site 941193013183 Switch I region; other site 941193013184 G2 box; other site 941193013185 Switch II region; other site 941193013186 G3 box; other site 941193013187 G4 box; other site 941193013188 G5 box; other site 941193013189 KH domain; Region: KH_2; pfam07650 941193013190 ribonuclease III; Reviewed; Region: rnc; PRK00102 941193013191 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 941193013192 dimerization interface [polypeptide binding]; other site 941193013193 active site 941193013194 metal binding site [ion binding]; metal-binding site 941193013195 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 941193013196 dsRNA binding site [nucleotide binding]; other site 941193013197 signal peptidase I; Provisional; Region: PRK10861 941193013198 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 941193013199 Catalytic site [active] 941193013200 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 941193013201 GTP-binding protein LepA; Provisional; Region: PRK05433 941193013202 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 941193013203 G1 box; other site 941193013204 putative GEF interaction site [polypeptide binding]; other site 941193013205 GTP/Mg2+ binding site [chemical binding]; other site 941193013206 Switch I region; other site 941193013207 G2 box; other site 941193013208 G3 box; other site 941193013209 Switch II region; other site 941193013210 G4 box; other site 941193013211 G5 box; other site 941193013212 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 941193013213 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 941193013214 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 941193013215 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 941193013216 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 941193013217 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 941193013218 protein binding site [polypeptide binding]; other site 941193013219 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 941193013220 protein binding site [polypeptide binding]; other site 941193013221 Positive regulator of sigma E activity [Signal transduction mechanisms]; Region: RseC; COG3086 941193013222 MucB/RseB family; Region: MucB_RseB; pfam03888 941193013223 anti-sigma E factor; Provisional; Region: rseB; PRK09455 941193013224 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073 941193013225 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 941193013226 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 941193013227 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 941193013228 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941193013229 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941193013230 DNA binding residues [nucleotide binding] 941193013231 L-aspartate oxidase; Provisional; Region: PRK09077 941193013232 L-aspartate oxidase; Provisional; Region: PRK06175 941193013233 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 941193013234 Uncharacterized conserved protein [Function unknown]; Region: COG2938 941193013235 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 941193013236 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 941193013237 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 941193013238 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 941193013239 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941193013240 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193013241 dimer interface [polypeptide binding]; other site 941193013242 phosphorylation site [posttranslational modification] 941193013243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193013244 ATP binding site [chemical binding]; other site 941193013245 G-X-G motif; other site 941193013246 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 941193013247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193013248 active site 941193013249 phosphorylation site [posttranslational modification] 941193013250 intermolecular recognition site; other site 941193013251 dimerization interface [polypeptide binding]; other site 941193013252 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193013253 DNA binding site [nucleotide binding] 941193013254 outer membrane porin, OprD family; Region: OprD; pfam03573 941193013255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 941193013256 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 941193013257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 941193013258 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 941193013259 Putative ammonia monooxygenase; Region: AmoA; pfam05145 941193013260 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 941193013261 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 941193013262 ligand binding site [chemical binding]; other site 941193013263 active site 941193013264 UGI interface [polypeptide binding]; other site 941193013265 catalytic site [active] 941193013266 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 941193013267 VanW like protein; Region: VanW; pfam04294 941193013268 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 941193013269 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941193013270 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193013271 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193013272 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 941193013273 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 941193013274 tetrameric interface [polypeptide binding]; other site 941193013275 NAD binding site [chemical binding]; other site 941193013276 catalytic residues [active] 941193013277 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941193013278 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 941193013279 substrate binding pocket [chemical binding]; other site 941193013280 FAD binding site [chemical binding]; other site 941193013281 catalytic base [active] 941193013282 enoyl-CoA hydratase; Provisional; Region: PRK09076 941193013283 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941193013284 substrate binding site [chemical binding]; other site 941193013285 oxyanion hole (OAH) forming residues; other site 941193013286 trimer interface [polypeptide binding]; other site 941193013287 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 941193013288 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941193013289 substrate binding site [chemical binding]; other site 941193013290 oxyanion hole (OAH) forming residues; other site 941193013291 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 941193013292 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 941193013293 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 941193013294 Ion channel; Region: Ion_trans_2; pfam07885 941193013295 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 941193013296 NADH(P)-binding; Region: NAD_binding_10; pfam13460 941193013297 NAD binding site [chemical binding]; other site 941193013298 substrate binding site [chemical binding]; other site 941193013299 putative active site [active] 941193013300 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 941193013301 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941193013302 SCP-2 sterol transfer family; Region: SCP2; pfam02036 941193013303 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193013304 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193013305 LysR substrate binding domain; Region: LysR_substrate; pfam03466 941193013306 dimerization interface [polypeptide binding]; other site 941193013307 Predicted membrane protein [Function unknown]; Region: COG3776 941193013308 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 941193013309 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 941193013310 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941193013311 RNA binding surface [nucleotide binding]; other site 941193013312 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 941193013313 active site 941193013314 uracil binding [chemical binding]; other site 941193013315 hypothetical protein; Provisional; Region: PRK06132 941193013316 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 941193013317 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 941193013318 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 941193013319 integrase; Provisional; Region: int; PHA02601 941193013320 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 941193013321 dimer interface [polypeptide binding]; other site 941193013322 active site 941193013323 catalytic residues [active] 941193013324 Int/Topo IB signature motif; other site 941193013325 Replication initiation factor; Region: Rep_trans; pfam02486 941193013326 putative assembly protein; Region: PHA00350 941193013327 Zonular occludens toxin (Zot); Region: Zot; cl17485 941193013328 hypothetical protein; Region: PHA01159 941193013329 Helix-turn-helix domain; Region: HTH_17; cl17695 941193013330 AAA domain; Region: AAA_23; pfam13476 941193013331 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193013332 Walker B; other site 941193013333 D-loop; other site 941193013334 H-loop/switch region; other site 941193013335 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 941193013336 hypothetical protein; Provisional; Region: PRK13687 941193013337 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 941193013338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941193013339 Coenzyme A binding pocket [chemical binding]; other site 941193013340 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941193013341 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 941193013342 dimer interface [polypeptide binding]; other site 941193013343 active site 941193013344 metal binding site [ion binding]; metal-binding site 941193013345 glutathione binding site [chemical binding]; other site 941193013346 Uncharacterized conserved protein [Function unknown]; Region: COG1359 941193013347 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193013348 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193013349 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193013350 dimerization interface [polypeptide binding]; other site 941193013351 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 941193013352 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 941193013353 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 941193013354 trimer interface [polypeptide binding]; other site 941193013355 active site 941193013356 substrate binding site [chemical binding]; other site 941193013357 CoA binding site [chemical binding]; other site 941193013358 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 941193013359 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 941193013360 active site 941193013361 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 941193013362 trimer interface [polypeptide binding]; other site 941193013363 active site 941193013364 substrate binding site [chemical binding]; other site 941193013365 CoA binding site [chemical binding]; other site 941193013366 amidase; Provisional; Region: PRK07042 941193013367 Amidase; Region: Amidase; pfam01425 941193013368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193013369 metabolite-proton symporter; Region: 2A0106; TIGR00883 941193013370 putative substrate translocation pore; other site 941193013371 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 941193013372 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 941193013373 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193013374 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193013375 LysR substrate binding domain; Region: LysR_substrate; pfam03466 941193013376 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 941193013377 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 941193013378 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 941193013379 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 941193013380 Gram-negative bacterial tonB protein; Region: TonB; cl10048 941193013381 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 941193013382 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 941193013383 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 941193013384 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 941193013385 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 941193013386 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 941193013387 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 941193013388 Surface antigen; Region: Bac_surface_Ag; pfam01103 941193013389 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 941193013390 haemagglutination activity domain; Region: Haemagg_act; pfam05860 941193013391 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 941193013392 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 941193013393 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 941193013394 type II secretion system protein F; Region: GspF; TIGR02120 941193013395 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 941193013396 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 941193013397 type II secretion system protein E; Region: type_II_gspE; TIGR02533 941193013398 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 941193013399 Walker A motif; other site 941193013400 ATP binding site [chemical binding]; other site 941193013401 Walker B motif; other site 941193013402 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 941193013403 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 941193013404 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 941193013405 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 941193013406 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 941193013407 Type II secretory pathway, component PulM [Intracellular trafficking and secretion]; Region: PulM; COG3149 941193013408 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 941193013409 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 941193013410 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 941193013411 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 941193013412 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 941193013413 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 941193013414 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 941193013415 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 941193013416 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 941193013417 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 941193013418 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 941193013419 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 941193013420 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 941193013421 FecR protein; Region: FecR; pfam04773 941193013422 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 941193013423 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941193013424 DNA binding residues [nucleotide binding] 941193013425 Secretin and TonB N terminus short domain; Region: STN; smart00965 941193013426 TonB C terminal; Region: TonB_2; pfam13103 941193013427 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 941193013428 heme binding pocket [chemical binding]; other site 941193013429 heme ligand [chemical binding]; other site 941193013430 Cell division inhibitor SulA; Region: SulA; cl01880 941193013431 DNA Polymerase Y-family; Region: PolY_like; cd03468 941193013432 active site 941193013433 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 941193013434 DNA binding site [nucleotide binding] 941193013435 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 941193013436 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 941193013437 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 941193013438 putative active site [active] 941193013439 putative PHP Thumb interface [polypeptide binding]; other site 941193013440 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 941193013441 generic binding surface II; other site 941193013442 generic binding surface I; other site 941193013443 exonuclease subunit SbcD; Provisional; Region: PRK10966 941193013444 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 941193013445 active site 941193013446 metal binding site [ion binding]; metal-binding site 941193013447 DNA binding site [nucleotide binding] 941193013448 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 941193013449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193013450 AAA domain; Region: AAA_23; pfam13476 941193013451 Walker A/P-loop; other site 941193013452 ATP binding site [chemical binding]; other site 941193013453 Q-loop/lid; other site 941193013454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193013455 ABC transporter signature motif; other site 941193013456 Walker B; other site 941193013457 D-loop; other site 941193013458 H-loop/switch region; other site 941193013459 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 941193013460 AAA domain; Region: AAA_30; pfam13604 941193013461 Family description; Region: UvrD_C_2; pfam13538 941193013462 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 941193013463 Family description; Region: UvrD_C_2; pfam13538 941193013464 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 941193013465 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 941193013466 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 941193013467 EamA-like transporter family; Region: EamA; pfam00892 941193013468 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 941193013469 Helix-turn-helix domain; Region: HTH_18; pfam12833 941193013470 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193013471 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 941193013472 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 941193013473 Chromate transporter; Region: Chromate_transp; pfam02417 941193013474 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941193013475 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193013476 dimer interface [polypeptide binding]; other site 941193013477 putative CheW interface [polypeptide binding]; other site 941193013478 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 941193013479 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 941193013480 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193013481 PAS fold; Region: PAS_3; pfam08447 941193013482 putative active site [active] 941193013483 heme pocket [chemical binding]; other site 941193013484 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193013485 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941193013486 putative active site [active] 941193013487 heme pocket [chemical binding]; other site 941193013488 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193013489 dimer interface [polypeptide binding]; other site 941193013490 phosphorylation site [posttranslational modification] 941193013491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193013492 ATP binding site [chemical binding]; other site 941193013493 Mg2+ binding site [ion binding]; other site 941193013494 G-X-G motif; other site 941193013495 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 941193013496 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 941193013497 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941193013498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193013499 active site 941193013500 phosphorylation site [posttranslational modification] 941193013501 intermolecular recognition site; other site 941193013502 dimerization interface [polypeptide binding]; other site 941193013503 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193013504 DNA binding residues [nucleotide binding] 941193013505 dimerization interface [polypeptide binding]; other site 941193013506 Predicted membrane protein [Function unknown]; Region: COG4655 941193013507 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 941193013508 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 941193013509 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 941193013510 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 941193013511 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 941193013512 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 941193013513 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 941193013514 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 941193013515 ATP binding site [chemical binding]; other site 941193013516 Walker A motif; other site 941193013517 hexamer interface [polypeptide binding]; other site 941193013518 Walker B motif; other site 941193013519 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 941193013520 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941193013521 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 941193013522 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 941193013523 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 941193013524 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 941193013525 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 941193013526 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 941193013527 Cache domain; Region: Cache_1; pfam02743 941193013528 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193013529 dimerization interface [polypeptide binding]; other site 941193013530 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941193013531 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193013532 dimer interface [polypeptide binding]; other site 941193013533 putative CheW interface [polypeptide binding]; other site 941193013534 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 941193013535 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 941193013536 Cache domain; Region: Cache_1; pfam02743 941193013537 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193013538 dimerization interface [polypeptide binding]; other site 941193013539 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941193013540 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193013541 dimer interface [polypeptide binding]; other site 941193013542 putative CheW interface [polypeptide binding]; other site 941193013543 Vibrio chemotaxis protein N terminus; Region: MCP_N; pfam05581 941193013544 Cache domain; Region: Cache_1; pfam02743 941193013545 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193013546 dimerization interface [polypeptide binding]; other site 941193013547 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941193013548 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193013549 dimer interface [polypeptide binding]; other site 941193013550 putative CheW interface [polypeptide binding]; other site 941193013551 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941193013552 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 941193013553 Predicted deacetylase [General function prediction only]; Region: COG3233 941193013554 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 941193013555 putative active site [active] 941193013556 putative Zn binding site [ion binding]; other site 941193013557 Predicted integral membrane protein [Function unknown]; Region: COG0392 941193013558 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 941193013559 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 941193013560 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 941193013561 putative active site [active] 941193013562 putative substrate binding site [chemical binding]; other site 941193013563 putative cosubstrate binding site; other site 941193013564 catalytic site [active] 941193013565 exonuclease I; Provisional; Region: sbcB; PRK11779 941193013566 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 941193013567 active site 941193013568 catalytic site [active] 941193013569 substrate binding site [chemical binding]; other site 941193013570 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 941193013571 Protein of unknown function (DUF975); Region: DUF975; cl10504 941193013572 Predicted membrane protein/domain [Function unknown]; Region: COG1714 941193013573 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 941193013574 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 941193013575 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193013576 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 941193013577 Walker A motif; other site 941193013578 ATP binding site [chemical binding]; other site 941193013579 Walker B motif; other site 941193013580 arginine finger; other site 941193013581 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 941193013582 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 941193013583 metal ion-dependent adhesion site (MIDAS); other site 941193013584 PilZ domain; Region: PilZ; pfam07238 941193013585 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 941193013586 universal stress protein UspE; Provisional; Region: PRK11175 941193013587 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 941193013588 Ligand Binding Site [chemical binding]; other site 941193013589 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 941193013590 Ligand Binding Site [chemical binding]; other site 941193013591 pyruvate kinase; Provisional; Region: PRK05826 941193013592 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 941193013593 domain interfaces; other site 941193013594 active site 941193013595 enoyl-CoA hydratase; Provisional; Region: PRK06688 941193013596 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941193013597 substrate binding site [chemical binding]; other site 941193013598 oxyanion hole (OAH) forming residues; other site 941193013599 trimer interface [polypeptide binding]; other site 941193013600 hypothetical protein; Provisional; Region: PRK05713 941193013601 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941193013602 catalytic loop [active] 941193013603 iron binding site [ion binding]; other site 941193013604 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 941193013605 FAD binding pocket [chemical binding]; other site 941193013606 conserved FAD binding motif [chemical binding]; other site 941193013607 phosphate binding motif [ion binding]; other site 941193013608 beta-alpha-beta structure motif; other site 941193013609 NAD binding pocket [chemical binding]; other site 941193013610 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193013611 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193013612 metal binding site [ion binding]; metal-binding site 941193013613 active site 941193013614 I-site; other site 941193013615 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 941193013616 Fumarase C-terminus; Region: Fumerase_C; pfam05683 941193013617 manganese transport protein MntH; Reviewed; Region: PRK00701 941193013618 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 941193013619 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 941193013620 intracellular protease, PfpI family; Region: PfpI; TIGR01382 941193013621 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 941193013622 conserved cys residue [active] 941193013623 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 941193013624 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 941193013625 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 941193013626 PLD-like domain; Region: PLDc_2; pfam13091 941193013627 putative active site [active] 941193013628 catalytic site [active] 941193013629 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 941193013630 PLD-like domain; Region: PLDc_2; pfam13091 941193013631 putative active site [active] 941193013632 catalytic site [active] 941193013633 YceI-like domain; Region: YceI; pfam04264 941193013634 Transcriptional regulator [Transcription]; Region: IclR; COG1414 941193013635 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 941193013636 amidase; Provisional; Region: PRK07486 941193013637 Amidase; Region: Amidase; pfam01425 941193013638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193013639 metabolite-proton symporter; Region: 2A0106; TIGR00883 941193013640 putative substrate translocation pore; other site 941193013641 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 941193013642 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 941193013643 metal binding site [ion binding]; metal-binding site 941193013644 putative dimer interface [polypeptide binding]; other site 941193013645 YceI-like domain; Region: YceI; pfam04264 941193013646 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 941193013647 Beta-lactamase; Region: Beta-lactamase; pfam00144 941193013648 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 941193013649 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941193013650 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193013651 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941193013652 active site 941193013653 Putative hemolysin [General function prediction only]; Region: COG3176 941193013654 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 941193013655 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 941193013656 putative acyl-acceptor binding pocket; other site 941193013657 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 941193013658 Ligand Binding Site [chemical binding]; other site 941193013659 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 941193013660 Ligand Binding Site [chemical binding]; other site 941193013661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3124 941193013662 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941193013663 dimerization interface [polypeptide binding]; other site 941193013664 putative DNA binding site [nucleotide binding]; other site 941193013665 putative Zn2+ binding site [ion binding]; other site 941193013666 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 941193013667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193013668 putative substrate translocation pore; other site 941193013669 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 941193013670 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 941193013671 FMN binding site [chemical binding]; other site 941193013672 active site 941193013673 substrate binding site [chemical binding]; other site 941193013674 catalytic residue [active] 941193013675 FeoC like transcriptional regulator; Region: FeoC; cl17677 941193013676 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 941193013677 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 941193013678 G1 box; other site 941193013679 GTP/Mg2+ binding site [chemical binding]; other site 941193013680 Switch I region; other site 941193013681 G2 box; other site 941193013682 G3 box; other site 941193013683 Switch II region; other site 941193013684 G4 box; other site 941193013685 G5 box; other site 941193013686 Nucleoside recognition; Region: Gate; pfam07670 941193013687 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 941193013688 Nucleoside recognition; Region: Gate; pfam07670 941193013689 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 941193013690 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 941193013691 oligomer interface [polypeptide binding]; other site 941193013692 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 941193013693 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193013694 NAD(P) binding site [chemical binding]; other site 941193013695 active site 941193013696 Uncharacterized conserved protein [Function unknown]; Region: COG3268 941193013697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193013698 NAD(P) binding site [chemical binding]; other site 941193013699 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 941193013700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193013701 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193013702 dimerization interface [polypeptide binding]; other site 941193013703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 941193013704 ACT domain; Region: ACT_3; pfam10000 941193013705 Lysine efflux permease [General function prediction only]; Region: COG1279 941193013706 superoxide dismutase; Provisional; Region: PRK10543 941193013707 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 941193013708 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 941193013709 biofilm formation regulator HmsP; Provisional; Region: PRK11829 941193013710 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193013711 metal binding site [ion binding]; metal-binding site 941193013712 active site 941193013713 I-site; other site 941193013714 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941193013715 E3 Ubiquitin ligase; Region: GIDE; pfam12483 941193013716 LemA family; Region: LemA; pfam04011 941193013717 Imelysin; Region: Peptidase_M75; cl09159 941193013718 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 941193013719 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 941193013720 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG3489 941193013721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 941193013722 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 941193013723 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193013724 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193013725 multidrug efflux protein; Reviewed; Region: PRK09579 941193013726 Protein export membrane protein; Region: SecD_SecF; cl14618 941193013727 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 941193013728 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 941193013729 active site 941193013730 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293 941193013731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193013732 S-adenosylmethionine binding site [chemical binding]; other site 941193013733 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941193013734 HAMP domain; Region: HAMP; pfam00672 941193013735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193013736 dimer interface [polypeptide binding]; other site 941193013737 phosphorylation site [posttranslational modification] 941193013738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193013739 ATP binding site [chemical binding]; other site 941193013740 Mg2+ binding site [ion binding]; other site 941193013741 G-X-G motif; other site 941193013742 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941193013743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193013744 active site 941193013745 phosphorylation site [posttranslational modification] 941193013746 intermolecular recognition site; other site 941193013747 dimerization interface [polypeptide binding]; other site 941193013748 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193013749 DNA binding site [nucleotide binding] 941193013750 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 941193013751 active site 941193013752 chromosome condensation membrane protein; Provisional; Region: PRK14196 941193013753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4318 941193013754 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 941193013755 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 941193013756 ring oligomerisation interface [polypeptide binding]; other site 941193013757 ATP/Mg binding site [chemical binding]; other site 941193013758 stacking interactions; other site 941193013759 hinge regions; other site 941193013760 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 941193013761 oligomerisation interface [polypeptide binding]; other site 941193013762 mobile loop; other site 941193013763 roof hairpin; other site 941193013764 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 941193013765 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 941193013766 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 941193013767 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 941193013768 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 941193013769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193013770 NAD(P) binding site [chemical binding]; other site 941193013771 active site 941193013772 Protein of unknown function, DUF481; Region: DUF481; pfam04338 941193013773 Protein of unknown function, DUF481; Region: DUF481; pfam04338 941193013774 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 941193013775 DNA binding site [nucleotide binding] 941193013776 active site 941193013777 AmpG-like permease; Region: 2A0125; TIGR00901 941193013778 muropeptide transporter; Validated; Region: ampG; cl17669 941193013779 mechanosensitive channel MscS; Provisional; Region: PRK10334 941193013780 Mechanosensitive ion channel; Region: MS_channel; pfam00924 941193013781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 941193013782 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 941193013783 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 941193013784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193013785 active site 941193013786 phosphorylation site [posttranslational modification] 941193013787 intermolecular recognition site; other site 941193013788 dimerization interface [polypeptide binding]; other site 941193013789 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 941193013790 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 941193013791 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 941193013792 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 941193013793 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193013794 dimerization interface [polypeptide binding]; other site 941193013795 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 941193013796 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193013797 putative active site [active] 941193013798 heme pocket [chemical binding]; other site 941193013799 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193013800 dimer interface [polypeptide binding]; other site 941193013801 phosphorylation site [posttranslational modification] 941193013802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193013803 ATP binding site [chemical binding]; other site 941193013804 Mg2+ binding site [ion binding]; other site 941193013805 G-X-G motif; other site 941193013806 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 941193013807 hypothetical protein; Provisional; Region: PRK08999 941193013808 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 941193013809 active site 941193013810 8-oxo-dGMP binding site [chemical binding]; other site 941193013811 nudix motif; other site 941193013812 metal binding site [ion binding]; metal-binding site 941193013813 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 941193013814 thiamine phosphate binding site [chemical binding]; other site 941193013815 active site 941193013816 pyrophosphate binding site [ion binding]; other site 941193013817 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 941193013818 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 941193013819 putative C-terminal domain interface [polypeptide binding]; other site 941193013820 putative GSH binding site (G-site) [chemical binding]; other site 941193013821 putative dimer interface [polypeptide binding]; other site 941193013822 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 941193013823 putative N-terminal domain interface [polypeptide binding]; other site 941193013824 putative dimer interface [polypeptide binding]; other site 941193013825 putative substrate binding pocket (H-site) [chemical binding]; other site 941193013826 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 941193013827 heterotetramer interface [polypeptide binding]; other site 941193013828 active site pocket [active] 941193013829 cleavage site 941193013830 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103 941193013831 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 941193013832 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 941193013833 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 941193013834 nucleotide binding region [chemical binding]; other site 941193013835 ATP-binding site [chemical binding]; other site 941193013836 SEC-C motif; Region: SEC-C; pfam02810 941193013837 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 941193013838 Peptidase family M23; Region: Peptidase_M23; pfam01551 941193013839 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 941193013840 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 941193013841 cell division protein FtsZ; Validated; Region: PRK09330 941193013842 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 941193013843 nucleotide binding site [chemical binding]; other site 941193013844 SulA interaction site; other site 941193013845 cell division protein FtsA; Region: ftsA; TIGR01174 941193013846 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 941193013847 nucleotide binding site [chemical binding]; other site 941193013848 Cell division protein FtsA; Region: FtsA; pfam14450 941193013849 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 941193013850 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 941193013851 Cell division protein FtsQ; Region: FtsQ; pfam03799 941193013852 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 941193013853 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 941193013854 ATP-grasp domain; Region: ATP-grasp_4; cl17255 941193013855 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 941193013856 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 941193013857 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941193013858 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 941193013859 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 941193013860 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 941193013861 active site 941193013862 homodimer interface [polypeptide binding]; other site 941193013863 cell division protein FtsW; Region: ftsW; TIGR02614 941193013864 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 941193013865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193013866 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941193013867 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 941193013868 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 941193013869 Mg++ binding site [ion binding]; other site 941193013870 putative catalytic motif [active] 941193013871 putative substrate binding site [chemical binding]; other site 941193013872 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 941193013873 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 941193013874 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941193013875 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 941193013876 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 941193013877 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 941193013878 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941193013879 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 941193013880 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 941193013881 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 941193013882 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 941193013883 Cell division protein [Cell division and chromosome partitioning]; Region: FtsL; COG3116 941193013884 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 941193013885 MraW methylase family; Region: Methyltransf_5; pfam01795 941193013886 cell division protein MraZ; Reviewed; Region: PRK00326 941193013887 MraZ protein; Region: MraZ; pfam02381 941193013888 Predicted methyltransferases [General function prediction only]; Region: COG0313 941193013889 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 941193013890 putative SAM binding site [chemical binding]; other site 941193013891 putative homodimer interface [polypeptide binding]; other site 941193013892 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 941193013893 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 941193013894 putative ligand binding site [chemical binding]; other site 941193013895 hypothetical protein; Reviewed; Region: PRK12497 941193013896 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 941193013897 dimer interface [polypeptide binding]; other site 941193013898 active site 941193013899 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 941193013900 BON domain; Region: BON; pfam04972 941193013901 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 941193013902 stringent starvation protein A; Provisional; Region: sspA; PRK09481 941193013903 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 941193013904 C-terminal domain interface [polypeptide binding]; other site 941193013905 putative GSH binding site (G-site) [chemical binding]; other site 941193013906 dimer interface [polypeptide binding]; other site 941193013907 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 941193013908 dimer interface [polypeptide binding]; other site 941193013909 N-terminal domain interface [polypeptide binding]; other site 941193013910 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 941193013911 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 941193013912 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 941193013913 Qi binding site; other site 941193013914 intrachain domain interface; other site 941193013915 interchain domain interface [polypeptide binding]; other site 941193013916 heme bH binding site [chemical binding]; other site 941193013917 heme bL binding site [chemical binding]; other site 941193013918 Qo binding site; other site 941193013919 interchain domain interface [polypeptide binding]; other site 941193013920 intrachain domain interface; other site 941193013921 Qi binding site; other site 941193013922 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 941193013923 Qo binding site; other site 941193013924 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 941193013925 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 941193013926 [2Fe-2S] cluster binding site [ion binding]; other site 941193013927 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 941193013928 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 941193013929 23S rRNA interface [nucleotide binding]; other site 941193013930 L3 interface [polypeptide binding]; other site 941193013931 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 941193013932 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 941193013933 active site 941193013934 catalytic tetrad [active] 941193013935 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941193013936 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193013937 active site 941193013938 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 941193013939 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 941193013940 conserved cys residue [active] 941193013941 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193013942 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193013943 Predicted ATPase [General function prediction only]; Region: COG1485 941193013944 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 941193013945 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 941193013946 active site 941193013947 HIGH motif; other site 941193013948 dimer interface [polypeptide binding]; other site 941193013949 KMSKS motif; other site 941193013950 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 941193013951 Serine hydrolase (FSH1); Region: FSH1; pfam03959 941193013952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 941193013953 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 941193013954 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 941193013955 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 941193013956 CysD dimerization site [polypeptide binding]; other site 941193013957 G1 box; other site 941193013958 putative GEF interaction site [polypeptide binding]; other site 941193013959 GTP/Mg2+ binding site [chemical binding]; other site 941193013960 Switch I region; other site 941193013961 G2 box; other site 941193013962 G3 box; other site 941193013963 Switch II region; other site 941193013964 G4 box; other site 941193013965 G5 box; other site 941193013966 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 941193013967 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 941193013968 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 941193013969 ligand-binding site [chemical binding]; other site 941193013970 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 941193013971 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 941193013972 Active Sites [active] 941193013973 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 941193013974 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 941193013975 N-acetyl-D-glucosamine binding site [chemical binding]; other site 941193013976 catalytic residue [active] 941193013977 Uncharacterized conserved protein [Function unknown]; Region: COG0327 941193013978 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 941193013979 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 941193013980 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 941193013981 protein binding site [polypeptide binding]; other site 941193013982 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 941193013983 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941193013984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193013985 homodimer interface [polypeptide binding]; other site 941193013986 catalytic residue [active] 941193013987 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 941193013988 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 941193013989 NAD binding site [chemical binding]; other site 941193013990 dimerization interface [polypeptide binding]; other site 941193013991 product binding site; other site 941193013992 substrate binding site [chemical binding]; other site 941193013993 zinc binding site [ion binding]; other site 941193013994 catalytic residues [active] 941193013995 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 941193013996 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 941193013997 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 941193013998 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 941193013999 hinge; other site 941193014000 active site 941193014001 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 941193014002 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 941193014003 anti sigma factor interaction site; other site 941193014004 regulatory phosphorylation site [posttranslational modification]; other site 941193014005 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; COG2854 941193014006 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 941193014007 mce related protein; Region: MCE; pfam02470 941193014008 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 941193014009 conserved hypothetical integral membrane protein; Region: TIGR00056 941193014010 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 941193014011 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 941193014012 Walker A/P-loop; other site 941193014013 ATP binding site [chemical binding]; other site 941193014014 Q-loop/lid; other site 941193014015 ABC transporter signature motif; other site 941193014016 Walker B; other site 941193014017 D-loop; other site 941193014018 H-loop/switch region; other site 941193014019 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 941193014020 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 941193014021 putative active site [active] 941193014022 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 941193014023 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 941193014024 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 941193014025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 941193014026 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 941193014027 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 941193014028 OstA-like protein; Region: OstA; pfam03968 941193014029 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 941193014030 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 941193014031 Walker A/P-loop; other site 941193014032 ATP binding site [chemical binding]; other site 941193014033 Q-loop/lid; other site 941193014034 ABC transporter signature motif; other site 941193014035 Walker B; other site 941193014036 D-loop; other site 941193014037 H-loop/switch region; other site 941193014038 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 941193014039 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 941193014040 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 941193014041 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 941193014042 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 941193014043 30S subunit binding site; other site 941193014044 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 941193014045 active site 941193014046 phosphorylation site [posttranslational modification] 941193014047 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 941193014048 AAA domain; Region: AAA_18; pfam13238 941193014049 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 941193014050 dimerization domain swap beta strand [polypeptide binding]; other site 941193014051 regulatory protein interface [polypeptide binding]; other site 941193014052 active site 941193014053 regulatory phosphorylation site [posttranslational modification]; other site 941193014054 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 941193014055 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 941193014056 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 941193014057 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 941193014058 Protein of unknown function (DUF2753); Region: DUF2753; pfam10952 941193014059 fumarate hydratase; Reviewed; Region: fumC; PRK00485 941193014060 Class II fumarases; Region: Fumarase_classII; cd01362 941193014061 active site 941193014062 tetramer interface [polypeptide binding]; other site 941193014063 peptidase PmbA; Provisional; Region: PRK11040 941193014064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3028 941193014065 protease TldD; Provisional; Region: tldD; PRK10735 941193014066 nitrilase; Region: PLN02798 941193014067 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 941193014068 putative active site [active] 941193014069 catalytic triad [active] 941193014070 dimer interface [polypeptide binding]; other site 941193014071 Predicted membrane protein [Function unknown]; Region: COG3164 941193014072 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 941193014073 ribonuclease G; Provisional; Region: PRK11712 941193014074 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 941193014075 homodimer interface [polypeptide binding]; other site 941193014076 oligonucleotide binding site [chemical binding]; other site 941193014077 Maf-like protein; Region: Maf; pfam02545 941193014078 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 941193014079 active site 941193014080 dimer interface [polypeptide binding]; other site 941193014081 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 941193014082 rod shape-determining protein MreC; Provisional; Region: PRK13922 941193014083 rod shape-determining protein MreC; Region: MreC; pfam04085 941193014084 rod shape-determining protein MreB; Provisional; Region: PRK13927 941193014085 MreB and similar proteins; Region: MreB_like; cd10225 941193014086 nucleotide binding site [chemical binding]; other site 941193014087 Mg binding site [ion binding]; other site 941193014088 putative protofilament interaction site [polypeptide binding]; other site 941193014089 RodZ interaction site [polypeptide binding]; other site 941193014090 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 941193014091 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 941193014092 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 941193014093 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 941193014094 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 941193014095 GatB domain; Region: GatB_Yqey; smart00845 941193014096 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 941193014097 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 941193014098 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 941193014099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 941193014100 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cl17565 941193014101 putative metal binding site [ion binding]; other site 941193014102 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 941193014103 Predicted secreted protein [Function unknown]; Region: COG5445 941193014104 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 941193014105 Predicted secreted protein [Function unknown]; Region: COG5445 941193014106 Stage II sporulation protein; Region: SpoIID; pfam08486 941193014107 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 941193014108 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 941193014109 MG2 domain; Region: A2M_N; pfam01835 941193014110 Alpha-2-macroglobulin family; Region: A2M; pfam00207 941193014111 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 941193014112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 941193014113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 941193014114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 941193014115 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 941193014116 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 941193014117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193014118 active site 941193014119 phosphorylation site [posttranslational modification] 941193014120 intermolecular recognition site; other site 941193014121 dimerization interface [polypeptide binding]; other site 941193014122 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941193014123 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941193014124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193014125 phosphorylation site [posttranslational modification] 941193014126 dimer interface [polypeptide binding]; other site 941193014127 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 941193014128 ATP binding site [chemical binding]; other site 941193014129 G-X-G motif; other site 941193014130 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3471 941193014131 Uncharacterized conserved protein [Function unknown]; Region: COG2968 941193014132 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 941193014133 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 941193014134 peptide binding site [polypeptide binding]; other site 941193014135 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 941193014136 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 941193014137 peptide binding site [polypeptide binding]; other site 941193014138 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 941193014139 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 941193014140 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 941193014141 active site 941193014142 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941193014143 non-specific DNA binding site [nucleotide binding]; other site 941193014144 salt bridge; other site 941193014145 sequence-specific DNA binding site [nucleotide binding]; other site 941193014146 Cupin domain; Region: Cupin_2; pfam07883 941193014147 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 941193014148 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 941193014149 peptide binding site [polypeptide binding]; other site 941193014150 outer membrane porin, OprD family; Region: OprD; pfam03573 941193014151 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 941193014152 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 941193014153 peptide binding site [polypeptide binding]; other site 941193014154 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 941193014155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193014156 dimer interface [polypeptide binding]; other site 941193014157 conserved gate region; other site 941193014158 putative PBP binding loops; other site 941193014159 ABC-ATPase subunit interface; other site 941193014160 dipeptide transporter; Provisional; Region: PRK10913 941193014161 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 941193014162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193014163 putative PBP binding loops; other site 941193014164 dimer interface [polypeptide binding]; other site 941193014165 ABC-ATPase subunit interface; other site 941193014166 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 941193014167 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941193014168 Walker A/P-loop; other site 941193014169 ATP binding site [chemical binding]; other site 941193014170 Q-loop/lid; other site 941193014171 ABC transporter signature motif; other site 941193014172 Walker B; other site 941193014173 D-loop; other site 941193014174 H-loop/switch region; other site 941193014175 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 941193014176 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 941193014177 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941193014178 Walker A/P-loop; other site 941193014179 ATP binding site [chemical binding]; other site 941193014180 Q-loop/lid; other site 941193014181 ABC transporter signature motif; other site 941193014182 Walker B; other site 941193014183 D-loop; other site 941193014184 H-loop/switch region; other site 941193014185 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 941193014186 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 941193014187 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941193014188 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941193014189 putative DNA binding site [nucleotide binding]; other site 941193014190 putative Zn2+ binding site [ion binding]; other site 941193014191 AsnC family; Region: AsnC_trans_reg; pfam01037 941193014192 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 941193014193 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 941193014194 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 941193014195 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 941193014196 putative active site [active] 941193014197 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 941193014198 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 941193014199 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 941193014200 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 941193014201 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 941193014202 Flavodoxin; Region: Flavodoxin_1; pfam00258 941193014203 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 941193014204 FAD binding pocket [chemical binding]; other site 941193014205 FAD binding motif [chemical binding]; other site 941193014206 catalytic residues [active] 941193014207 NAD binding pocket [chemical binding]; other site 941193014208 phosphate binding motif [ion binding]; other site 941193014209 beta-alpha-beta structure motif; other site 941193014210 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 941193014211 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193014212 N-terminal plug; other site 941193014213 ligand-binding site [chemical binding]; other site 941193014214 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 941193014215 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 941193014216 Sel1-like repeats; Region: SEL1; smart00671 941193014217 Sel1-like repeats; Region: SEL1; smart00671 941193014218 hypothetical protein; Provisional; Region: PRK10649 941193014219 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 941193014220 Sulfatase; Region: Sulfatase; pfam00884 941193014221 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 941193014222 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941193014223 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 941193014224 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 941193014225 dimer interface [polypeptide binding]; other site 941193014226 active site 941193014227 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941193014228 catalytic residues [active] 941193014229 substrate binding site [chemical binding]; other site 941193014230 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 941193014231 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193014232 dimerization interface [polypeptide binding]; other site 941193014233 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193014234 dimer interface [polypeptide binding]; other site 941193014235 putative CheW interface [polypeptide binding]; other site 941193014236 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896 941193014237 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 941193014238 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 941193014239 amidase catalytic site [active] 941193014240 Zn binding residues [ion binding]; other site 941193014241 substrate binding site [chemical binding]; other site 941193014242 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 941193014243 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742 941193014244 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 941193014245 dimerization interface [polypeptide binding]; other site 941193014246 active site 941193014247 O-Antigen ligase; Region: Wzy_C; pfam04932 941193014248 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 941193014249 Pilin (bacterial filament); Region: Pilin; pfam00114 941193014250 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 941193014251 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 941193014252 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 941193014253 Walker A motif; other site 941193014254 ATP binding site [chemical binding]; other site 941193014255 Walker B motif; other site 941193014256 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 941193014257 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 941193014258 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 941193014259 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 941193014260 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 941193014261 CoA-binding site [chemical binding]; other site 941193014262 ATP-binding [chemical binding]; other site 941193014263 DNA gyrase inhibitor; Reviewed; Region: PRK00418 941193014264 Predicted membrane protein [Function unknown]; Region: COG3235 941193014265 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 941193014266 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 941193014267 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941193014268 Coenzyme A binding pocket [chemical binding]; other site 941193014269 Protein of unknown function (DUF1780); Region: DUF1780; pfam08682 941193014270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 941193014271 MOSC domain; Region: MOSC; pfam03473 941193014272 Protein of unknown function (DUF3094); Region: DUF3094; pfam11293 941193014273 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 941193014274 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941193014275 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 941193014276 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 941193014277 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 941193014278 Surface antigen; Region: Bac_surface_Ag; pfam01103 941193014279 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 941193014280 haemagglutination activity domain; Region: Haemagg_act; pfam05860 941193014281 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 941193014282 Clp amino terminal domain; Region: Clp_N; pfam02861 941193014283 Clp amino terminal domain; Region: Clp_N; pfam02861 941193014284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193014285 Walker A motif; other site 941193014286 ATP binding site [chemical binding]; other site 941193014287 Walker B motif; other site 941193014288 arginine finger; other site 941193014289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193014290 Walker A motif; other site 941193014291 ATP binding site [chemical binding]; other site 941193014292 Walker B motif; other site 941193014293 arginine finger; other site 941193014294 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 941193014295 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 941193014296 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 941193014297 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 941193014298 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941193014299 RNA binding surface [nucleotide binding]; other site 941193014300 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 941193014301 active site 941193014302 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 941193014303 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 941193014304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193014305 dimer interface [polypeptide binding]; other site 941193014306 phosphorylation site [posttranslational modification] 941193014307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193014308 ATP binding site [chemical binding]; other site 941193014309 Mg2+ binding site [ion binding]; other site 941193014310 G-X-G motif; other site 941193014311 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 941193014312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193014313 active site 941193014314 phosphorylation site [posttranslational modification] 941193014315 intermolecular recognition site; other site 941193014316 dimerization interface [polypeptide binding]; other site 941193014317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193014318 Walker A motif; other site 941193014319 ATP binding site [chemical binding]; other site 941193014320 Walker B motif; other site 941193014321 arginine finger; other site 941193014322 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941193014323 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941193014324 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 941193014325 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 941193014326 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 941193014327 Type II transport protein GspH; Region: GspH; pfam12019 941193014328 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 941193014329 Type II transport protein GspH; Region: GspH; pfam12019 941193014330 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 941193014331 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 941193014332 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 941193014333 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 941193014334 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 941193014335 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 941193014336 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 941193014337 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 941193014338 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 941193014339 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 941193014340 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 941193014341 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 941193014342 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 941193014343 lipoprotein signal peptidase; Provisional; Region: PRK14787 941193014344 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 941193014345 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 941193014346 active site 941193014347 HIGH motif; other site 941193014348 nucleotide binding site [chemical binding]; other site 941193014349 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 941193014350 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 941193014351 active site 941193014352 KMSKS motif; other site 941193014353 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 941193014354 tRNA binding surface [nucleotide binding]; other site 941193014355 anticodon binding site; other site 941193014356 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 941193014357 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 941193014358 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 941193014359 active site 941193014360 Riboflavin kinase; Region: Flavokinase; pfam01687 941193014361 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 941193014362 MviN-like protein; Region: MVIN; pfam03023 941193014363 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 941193014364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 941193014365 CreA protein; Region: CreA; pfam05981 941193014366 gamma-glutamyl kinase; Provisional; Region: PRK05429 941193014367 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 941193014368 nucleotide binding site [chemical binding]; other site 941193014369 homotetrameric interface [polypeptide binding]; other site 941193014370 putative phosphate binding site [ion binding]; other site 941193014371 putative allosteric binding site; other site 941193014372 PUA domain; Region: PUA; pfam01472 941193014373 GTPase CgtA; Reviewed; Region: obgE; PRK12298 941193014374 GTP1/OBG; Region: GTP1_OBG; pfam01018 941193014375 Obg GTPase; Region: Obg; cd01898 941193014376 G1 box; other site 941193014377 GTP/Mg2+ binding site [chemical binding]; other site 941193014378 Switch I region; other site 941193014379 G2 box; other site 941193014380 G3 box; other site 941193014381 Switch II region; other site 941193014382 G4 box; other site 941193014383 G5 box; other site 941193014384 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 941193014385 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 941193014386 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 941193014387 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 941193014388 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 941193014389 substrate binding pocket [chemical binding]; other site 941193014390 chain length determination region; other site 941193014391 substrate-Mg2+ binding site; other site 941193014392 catalytic residues [active] 941193014393 aspartate-rich region 1; other site 941193014394 active site lid residues [active] 941193014395 aspartate-rich region 2; other site 941193014396 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 941193014397 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 941193014398 Cytochrome c; Region: Cytochrom_C; pfam00034 941193014399 Cytochrome c [Energy production and conversion]; Region: COG3258 941193014400 Cytochrome c; Region: Cytochrom_C; pfam00034 941193014401 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 941193014402 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 941193014403 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 941193014404 hypothetical protein; Provisional; Region: PRK05208 941193014405 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 941193014406 AAA domain; Region: AAA_32; pfam13654 941193014407 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 941193014408 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 941193014409 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 941193014410 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 941193014411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 941193014412 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 941193014413 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 941193014414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193014415 Walker A motif; other site 941193014416 ATP binding site [chemical binding]; other site 941193014417 Walker B motif; other site 941193014418 arginine finger; other site 941193014419 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 941193014420 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 941193014421 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 941193014422 hypothetical protein; Reviewed; Region: PRK09588 941193014423 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 941193014424 active site 941193014425 NTP binding site [chemical binding]; other site 941193014426 metal binding triad [ion binding]; metal-binding site 941193014427 antibiotic binding site [chemical binding]; other site 941193014428 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 941193014429 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 941193014430 putative active site [active] 941193014431 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 941193014432 glutamate dehydrogenase; Provisional; Region: PRK09414 941193014433 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 941193014434 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 941193014435 NAD(P) binding site [chemical binding]; other site 941193014436 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 941193014437 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 941193014438 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193014439 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193014440 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 941193014441 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 941193014442 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 941193014443 FtsX-like permease family; Region: FtsX; pfam02687 941193014444 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 941193014445 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 941193014446 Walker A/P-loop; other site 941193014447 ATP binding site [chemical binding]; other site 941193014448 Q-loop/lid; other site 941193014449 ABC transporter signature motif; other site 941193014450 Walker B; other site 941193014451 D-loop; other site 941193014452 H-loop/switch region; other site 941193014453 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 941193014454 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941193014455 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941193014456 ABC transporter; Region: ABC_tran_2; pfam12848 941193014457 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941193014458 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193014459 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193014460 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 941193014461 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 941193014462 Protein export membrane protein; Region: SecD_SecF; cl14618 941193014463 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 941193014464 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193014465 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193014466 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193014467 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 941193014468 PAS domain; Region: PAS_9; pfam13426 941193014469 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193014470 PAS fold; Region: PAS_3; pfam08447 941193014471 putative active site [active] 941193014472 heme pocket [chemical binding]; other site 941193014473 PAS domain; Region: PAS_9; pfam13426 941193014474 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 941193014475 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193014476 PAS domain; Region: PAS_9; pfam13426 941193014477 putative active site [active] 941193014478 heme pocket [chemical binding]; other site 941193014479 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193014480 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193014481 metal binding site [ion binding]; metal-binding site 941193014482 active site 941193014483 I-site; other site 941193014484 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941193014485 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 941193014486 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 941193014487 dimer interface [polypeptide binding]; other site 941193014488 active site 941193014489 glycine-pyridoxal phosphate binding site [chemical binding]; other site 941193014490 folate binding site [chemical binding]; other site 941193014491 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 941193014492 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 941193014493 P-loop, Walker A motif; other site 941193014494 Base recognition motif; other site 941193014495 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 941193014496 Uncharacterized small protein [Function unknown]; Region: COG2879 941193014497 carbon starvation protein A; Provisional; Region: PRK15015 941193014498 Carbon starvation protein CstA; Region: CstA; pfam02554 941193014499 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 941193014500 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 941193014501 PilZ domain; Region: PilZ; pfam07238 941193014502 DNA repair protein RadA; Provisional; Region: PRK11823 941193014503 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 941193014504 Walker A motif/ATP binding site; other site 941193014505 ATP binding site [chemical binding]; other site 941193014506 Walker B motif; other site 941193014507 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 941193014508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 941193014509 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 941193014510 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 941193014511 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 941193014512 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 941193014513 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 941193014514 tetramer interface [polypeptide binding]; other site 941193014515 heme binding pocket [chemical binding]; other site 941193014516 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 941193014517 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 941193014518 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 941193014519 ferredoxin-NADP reductase; Provisional; Region: PRK10926 941193014520 FAD binding pocket [chemical binding]; other site 941193014521 FAD binding motif [chemical binding]; other site 941193014522 phosphate binding motif [ion binding]; other site 941193014523 beta-alpha-beta structure motif; other site 941193014524 NAD binding pocket [chemical binding]; other site 941193014525 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 941193014526 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 941193014527 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 941193014528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193014529 S-adenosylmethionine binding site [chemical binding]; other site 941193014530 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 941193014531 Ligand binding site; other site 941193014532 metal-binding site 941193014533 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 941193014534 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 941193014535 XdhC Rossmann domain; Region: XdhC_C; pfam13478 941193014536 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 941193014537 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 941193014538 Cytochrome c; Region: Cytochrom_C; pfam00034 941193014539 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 941193014540 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 941193014541 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 941193014542 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 941193014543 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 941193014544 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 941193014545 H+ Antiporter protein; Region: 2A0121; TIGR00900 941193014546 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 941193014547 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 941193014548 haemagglutination activity domain; Region: Haemagg_act; pfam05860 941193014549 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 941193014550 glycerate dehydrogenase; Provisional; Region: PRK06487 941193014551 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 941193014552 putative ligand binding site [chemical binding]; other site 941193014553 putative NAD binding site [chemical binding]; other site 941193014554 catalytic site [active] 941193014555 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 941193014556 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 941193014557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193014558 S-adenosylmethionine binding site [chemical binding]; other site 941193014559 lysine transporter; Provisional; Region: PRK10836 941193014560 Predicted membrane protein [Function unknown]; Region: COG2119 941193014561 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 941193014562 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 941193014563 conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096 941193014564 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 941193014565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193014566 NAD(P) binding site [chemical binding]; other site 941193014567 active site 941193014568 Peptidase family M48; Region: Peptidase_M48; pfam01435 941193014569 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193014570 dimerization interface [polypeptide binding]; other site 941193014571 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941193014572 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193014573 dimer interface [polypeptide binding]; other site 941193014574 putative CheW interface [polypeptide binding]; other site 941193014575 Uncharacterized conserved protein [Function unknown]; Region: COG2135 941193014576 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 941193014577 MgtC family; Region: MgtC; pfam02308 941193014578 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 941193014579 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 941193014580 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 941193014581 putative acyl-acceptor binding pocket; other site 941193014582 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 941193014583 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 941193014584 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 941193014585 dimer interface [polypeptide binding]; other site 941193014586 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941193014587 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 941193014588 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941193014589 active site 941193014590 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941193014591 active site 941193014592 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 941193014593 Uncharacterized secreted protein [Function unknown]; Region: COG5430 941193014594 Uncharacterized secreted protein [Function unknown]; Region: COG5430 941193014595 Uncharacterized secreted protein [Function unknown]; Region: COG5430 941193014596 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 941193014597 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 941193014598 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 941193014599 PapC N-terminal domain; Region: PapC_N; pfam13954 941193014600 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 941193014601 PapC C-terminal domain; Region: PapC_C; pfam13953 941193014602 Spore Coat Protein U domain; Region: SCPU; pfam05229 941193014603 Uncharacterized secreted protein [Function unknown]; Region: COG5430 941193014604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193014605 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941193014606 putative substrate translocation pore; other site 941193014607 ferrochelatase; Reviewed; Region: hemH; PRK00035 941193014608 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 941193014609 C-terminal domain interface [polypeptide binding]; other site 941193014610 active site 941193014611 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 941193014612 active site 941193014613 N-terminal domain interface [polypeptide binding]; other site 941193014614 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 941193014615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193014616 NAD(P) binding site [chemical binding]; other site 941193014617 active site 941193014618 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 941193014619 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941193014620 Protein of unknown function (DUF523); Region: DUF523; pfam04463 941193014621 Uncharacterized conserved protein [Function unknown]; Region: COG3272 941193014622 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 941193014623 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 941193014624 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 941193014625 DNA binding residues [nucleotide binding] 941193014626 B12 binding domain; Region: B12-binding_2; pfam02607 941193014627 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 941193014628 DNA photolyase; Region: DNA_photolyase; pfam00875 941193014629 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 941193014630 glutamate racemase; Provisional; Region: PRK00865 941193014631 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 941193014632 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 941193014633 ATP binding site [chemical binding]; other site 941193014634 substrate interface [chemical binding]; other site 941193014635 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 941193014636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193014637 peptide chain release factor 1; Validated; Region: prfA; PRK00591 941193014638 This domain is found in peptide chain release factors; Region: PCRF; smart00937 941193014639 RF-1 domain; Region: RF-1; pfam00472 941193014640 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 941193014641 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 941193014642 tRNA; other site 941193014643 putative tRNA binding site [nucleotide binding]; other site 941193014644 putative NADP binding site [chemical binding]; other site 941193014645 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 941193014646 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 941193014647 TPR motif; other site 941193014648 binding surface 941193014649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941193014650 binding surface 941193014651 TPR motif; other site 941193014652 Tetratricopeptide repeat; Region: TPR_16; pfam13432 941193014653 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941193014654 binding surface 941193014655 TPR motif; other site 941193014656 TPR repeat; Region: TPR_11; pfam13414 941193014657 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941193014658 binding surface 941193014659 TPR motif; other site 941193014660 Tetratricopeptide repeat; Region: TPR_12; pfam13424 941193014661 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 941193014662 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 941193014663 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 941193014664 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 941193014665 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 941193014666 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941193014667 active site 941193014668 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 941193014669 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 941193014670 5S rRNA interface [nucleotide binding]; other site 941193014671 CTC domain interface [polypeptide binding]; other site 941193014672 L16 interface [polypeptide binding]; other site 941193014673 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 941193014674 metal binding site [ion binding]; metal-binding site 941193014675 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 941193014676 putative active site [active] 941193014677 catalytic residue [active] 941193014678 GTP-binding protein YchF; Reviewed; Region: PRK09601 941193014679 YchF GTPase; Region: YchF; cd01900 941193014680 G1 box; other site 941193014681 GTP/Mg2+ binding site [chemical binding]; other site 941193014682 Switch I region; other site 941193014683 G2 box; other site 941193014684 Switch II region; other site 941193014685 G3 box; other site 941193014686 G4 box; other site 941193014687 G5 box; other site 941193014688 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 941193014689 integrase; Provisional; Region: int; PHA02601 941193014690 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 941193014691 active site 941193014692 DNA binding site [nucleotide binding] 941193014693 Int/Topo IB signature motif; other site 941193014694 putative assembly protein; Region: PHA00350 941193014695 Zonular occludens toxin (Zot); Region: Zot; cl17485 941193014696 hypothetical protein; Region: PHA01159 941193014697 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 941193014698 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 941193014699 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193014700 N-terminal plug; other site 941193014701 ligand-binding site [chemical binding]; other site 941193014702 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 941193014703 active site clefts [active] 941193014704 zinc binding site [ion binding]; other site 941193014705 dimer interface [polypeptide binding]; other site 941193014706 Peptidase family C69; Region: Peptidase_C69; cl17793 941193014707 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 941193014708 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 941193014709 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 941193014710 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 941193014711 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 941193014712 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 941193014713 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 941193014714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193014715 dimer interface [polypeptide binding]; other site 941193014716 conserved gate region; other site 941193014717 putative PBP binding loops; other site 941193014718 ABC-ATPase subunit interface; other site 941193014719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193014720 dimer interface [polypeptide binding]; other site 941193014721 conserved gate region; other site 941193014722 putative PBP binding loops; other site 941193014723 ABC-ATPase subunit interface; other site 941193014724 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 941193014725 mce related protein; Region: MCE; pfam02470 941193014726 mce related protein; Region: MCE; pfam02470 941193014727 mce related protein; Region: MCE; pfam02470 941193014728 mce related protein; Region: MCE; pfam02470 941193014729 mce related protein; Region: MCE; pfam02470 941193014730 mce related protein; Region: MCE; pfam02470 941193014731 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 941193014732 Paraquat-inducible protein A; Region: PqiA; pfam04403 941193014733 Paraquat-inducible protein A; Region: PqiA; pfam04403 941193014734 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 941193014735 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 941193014736 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 941193014737 Moco binding site; other site 941193014738 metal coordination site [ion binding]; other site 941193014739 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 941193014740 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 941193014741 ketol-acid reductoisomerase; Provisional; Region: PRK05479 941193014742 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 941193014743 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 941193014744 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 941193014745 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 941193014746 putative valine binding site [chemical binding]; other site 941193014747 dimer interface [polypeptide binding]; other site 941193014748 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 941193014749 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 941193014750 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 941193014751 PYR/PP interface [polypeptide binding]; other site 941193014752 dimer interface [polypeptide binding]; other site 941193014753 TPP binding site [chemical binding]; other site 941193014754 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 941193014755 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 941193014756 TPP-binding site [chemical binding]; other site 941193014757 dimer interface [polypeptide binding]; other site 941193014758 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 941193014759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 941193014760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941193014761 TPR motif; other site 941193014762 binding surface 941193014763 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 941193014764 Transglycosylase; Region: Transgly; pfam00912 941193014765 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 941193014766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 941193014767 Predicted kinase [General function prediction only]; Region: COG0645 941193014768 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 941193014769 ATP-binding site [chemical binding]; other site 941193014770 Gluconate-6-phosphate binding site [chemical binding]; other site 941193014771 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 941193014772 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 941193014773 TfoX C-terminal domain; Region: TfoX_C; pfam04994 941193014774 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 941193014775 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 941193014776 ligand binding site [chemical binding]; other site 941193014777 flexible hinge region; other site 941193014778 Uncharacterized iron-regulated protein [Function unknown]; Region: PhuW; COG3016 941193014779 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 941193014780 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 941193014781 Walker A/P-loop; other site 941193014782 ATP binding site [chemical binding]; other site 941193014783 Q-loop/lid; other site 941193014784 ABC transporter signature motif; other site 941193014785 Walker B; other site 941193014786 D-loop; other site 941193014787 H-loop/switch region; other site 941193014788 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 941193014789 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941193014790 ABC-ATPase subunit interface; other site 941193014791 dimer interface [polypeptide binding]; other site 941193014792 putative PBP binding regions; other site 941193014793 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 941193014794 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 941193014795 putative hemin binding site; other site 941193014796 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 941193014797 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 941193014798 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 941193014799 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 941193014800 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193014801 N-terminal plug; other site 941193014802 ligand-binding site [chemical binding]; other site 941193014803 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 941193014804 iron-sulfur cluster [ion binding]; other site 941193014805 [2Fe-2S] cluster binding site [ion binding]; other site 941193014806 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 941193014807 Predicted metal-binding protein [General function prediction only]; Region: COG3019 941193014808 aminotransferase; Validated; Region: PRK08175 941193014809 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941193014810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193014811 homodimer interface [polypeptide binding]; other site 941193014812 catalytic residue [active] 941193014813 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 941193014814 Predicted metalloprotease [General function prediction only]; Region: COG2321 941193014815 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 941193014816 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 941193014817 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 941193014818 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 941193014819 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 941193014820 hypothetical protein; Provisional; Region: PRK08960 941193014821 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941193014822 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193014823 homodimer interface [polypeptide binding]; other site 941193014824 catalytic residue [active] 941193014825 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 941193014826 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 941193014827 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 941193014828 active site 941193014829 HIGH motif; other site 941193014830 nucleotide binding site [chemical binding]; other site 941193014831 KMSKS motif; other site 941193014832 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 941193014833 Na binding site [ion binding]; other site 941193014834 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 941193014835 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 941193014836 putative active site [active] 941193014837 heme pocket [chemical binding]; other site 941193014838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193014839 dimer interface [polypeptide binding]; other site 941193014840 phosphorylation site [posttranslational modification] 941193014841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193014842 ATP binding site [chemical binding]; other site 941193014843 Mg2+ binding site [ion binding]; other site 941193014844 G-X-G motif; other site 941193014845 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 941193014846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193014847 active site 941193014848 phosphorylation site [posttranslational modification] 941193014849 intermolecular recognition site; other site 941193014850 dimerization interface [polypeptide binding]; other site 941193014851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193014852 Walker A motif; other site 941193014853 ATP binding site [chemical binding]; other site 941193014854 Walker B motif; other site 941193014855 arginine finger; other site 941193014856 poly(A) polymerase; Region: pcnB; TIGR01942 941193014857 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 941193014858 active site 941193014859 NTP binding site [chemical binding]; other site 941193014860 metal binding triad [ion binding]; metal-binding site 941193014861 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 941193014862 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 941193014863 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 941193014864 catalytic center binding site [active] 941193014865 ATP binding site [chemical binding]; other site 941193014866 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 941193014867 oligomerization interface [polypeptide binding]; other site 941193014868 active site 941193014869 metal binding site [ion binding]; metal-binding site 941193014870 Pantoate-beta-alanine ligase; Region: PanC; cd00560 941193014871 pantoate--beta-alanine ligase; Region: panC; TIGR00018 941193014872 active site 941193014873 ATP-binding site [chemical binding]; other site 941193014874 pantoate-binding site; other site 941193014875 HXXH motif; other site 941193014876 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 941193014877 tetramerization interface [polypeptide binding]; other site 941193014878 active site 941193014879 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 941193014880 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 941193014881 active site 941193014882 dimer interface [polypeptide binding]; other site 941193014883 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 941193014884 dimer interface [polypeptide binding]; other site 941193014885 active site 941193014886 acetyl-CoA synthetase; Provisional; Region: PRK00174 941193014887 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 941193014888 active site 941193014889 CoA binding site [chemical binding]; other site 941193014890 acyl-activating enzyme (AAE) consensus motif; other site 941193014891 AMP binding site [chemical binding]; other site 941193014892 acetate binding site [chemical binding]; other site 941193014893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 941193014894 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 941193014895 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 941193014896 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 941193014897 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 941193014898 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 941193014899 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 941193014900 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 941193014901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 941193014902 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 941193014903 BON domain; Region: BON; pfam04972 941193014904 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 941193014905 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 941193014906 RNase E interface [polypeptide binding]; other site 941193014907 trimer interface [polypeptide binding]; other site 941193014908 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 941193014909 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 941193014910 RNase E interface [polypeptide binding]; other site 941193014911 trimer interface [polypeptide binding]; other site 941193014912 active site 941193014913 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 941193014914 putative nucleic acid binding region [nucleotide binding]; other site 941193014915 G-X-X-G motif; other site 941193014916 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 941193014917 RNA binding site [nucleotide binding]; other site 941193014918 domain interface; other site 941193014919 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 941193014920 16S/18S rRNA binding site [nucleotide binding]; other site 941193014921 S13e-L30e interaction site [polypeptide binding]; other site 941193014922 25S rRNA binding site [nucleotide binding]; other site 941193014923 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 941193014924 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 941193014925 RNA binding site [nucleotide binding]; other site 941193014926 active site 941193014927 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 941193014928 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 941193014929 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 941193014930 translation initiation factor IF-2; Region: IF-2; TIGR00487 941193014931 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 941193014932 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 941193014933 G1 box; other site 941193014934 putative GEF interaction site [polypeptide binding]; other site 941193014935 GTP/Mg2+ binding site [chemical binding]; other site 941193014936 Switch I region; other site 941193014937 G2 box; other site 941193014938 G3 box; other site 941193014939 Switch II region; other site 941193014940 G4 box; other site 941193014941 G5 box; other site 941193014942 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 941193014943 Translation-initiation factor 2; Region: IF-2; pfam11987 941193014944 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 941193014945 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 941193014946 NusA N-terminal domain; Region: NusA_N; pfam08529 941193014947 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 941193014948 RNA binding site [nucleotide binding]; other site 941193014949 homodimer interface [polypeptide binding]; other site 941193014950 NusA-like KH domain; Region: KH_5; pfam13184 941193014951 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 941193014952 G-X-X-G motif; other site 941193014953 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 941193014954 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 941193014955 ribosome maturation protein RimP; Reviewed; Region: PRK00092 941193014956 Sm and related proteins; Region: Sm_like; cl00259 941193014957 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 941193014958 putative oligomer interface [polypeptide binding]; other site 941193014959 putative RNA binding site [nucleotide binding]; other site 941193014960 Preprotein translocase SecG subunit; Region: SecG; pfam03840 941193014961 triosephosphate isomerase; Provisional; Region: PRK14567 941193014962 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 941193014963 dimer interface [polypeptide binding]; other site 941193014964 substrate binding site [chemical binding]; other site 941193014965 catalytic triad [active] 941193014966 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 941193014967 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 941193014968 active site 941193014969 substrate binding site [chemical binding]; other site 941193014970 metal binding site [ion binding]; metal-binding site 941193014971 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 941193014972 dihydropteroate synthase; Region: DHPS; TIGR01496 941193014973 substrate binding pocket [chemical binding]; other site 941193014974 dimer interface [polypeptide binding]; other site 941193014975 inhibitor binding site; inhibition site 941193014976 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 941193014977 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193014978 Walker A motif; other site 941193014979 ATP binding site [chemical binding]; other site 941193014980 Walker B motif; other site 941193014981 arginine finger; other site 941193014982 Peptidase family M41; Region: Peptidase_M41; pfam01434 941193014983 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 941193014984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193014985 S-adenosylmethionine binding site [chemical binding]; other site 941193014986 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 941193014987 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 941193014988 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 941193014989 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 941193014990 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 941193014991 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 941193014992 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 941193014993 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 941193014994 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 941193014995 ATP-grasp domain; Region: ATP-grasp_4; cl17255 941193014996 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 941193014997 IMP binding site; other site 941193014998 dimer interface [polypeptide binding]; other site 941193014999 interdomain contacts; other site 941193015000 partial ornithine binding site; other site 941193015001 leucine export protein LeuE; Provisional; Region: PRK10958 941193015002 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 941193015003 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 941193015004 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 941193015005 catalytic site [active] 941193015006 subunit interface [polypeptide binding]; other site 941193015007 dihydrodipicolinate reductase; Provisional; Region: PRK00048 941193015008 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 941193015009 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 941193015010 chaperone protein DnaJ; Provisional; Region: PRK10767 941193015011 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 941193015012 HSP70 interaction site [polypeptide binding]; other site 941193015013 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 941193015014 substrate binding site [polypeptide binding]; other site 941193015015 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 941193015016 Zn binding sites [ion binding]; other site 941193015017 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 941193015018 dimer interface [polypeptide binding]; other site 941193015019 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 941193015020 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 941193015021 nucleotide binding site [chemical binding]; other site 941193015022 GrpE; Region: GrpE; pfam01025 941193015023 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 941193015024 dimer interface [polypeptide binding]; other site 941193015025 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 941193015026 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 941193015027 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 941193015028 Walker A/P-loop; other site 941193015029 ATP binding site [chemical binding]; other site 941193015030 Q-loop/lid; other site 941193015031 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 941193015032 ABC transporter signature motif; other site 941193015033 Walker B; other site 941193015034 D-loop; other site 941193015035 H-loop/switch region; other site 941193015036 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 941193015037 metal binding site 2 [ion binding]; metal-binding site 941193015038 putative DNA binding helix; other site 941193015039 metal binding site 1 [ion binding]; metal-binding site 941193015040 dimer interface [polypeptide binding]; other site 941193015041 structural Zn2+ binding site [ion binding]; other site 941193015042 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 941193015043 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 941193015044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 941193015045 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 941193015046 putative coenzyme Q binding site [chemical binding]; other site 941193015047 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 941193015048 SmpB-tmRNA interface; other site 941193015049 Transcriptional regulators [Transcription]; Region: FadR; COG2186 941193015050 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193015051 DNA-binding site [nucleotide binding]; DNA binding site 941193015052 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 941193015053 glycolate transporter; Provisional; Region: PRK09695 941193015054 L-lactate permease; Region: Lactate_perm; cl00701 941193015055 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 941193015056 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 941193015057 phosphate binding site [ion binding]; other site 941193015058 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 941193015059 FAD binding domain; Region: FAD_binding_4; pfam01565 941193015060 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 941193015061 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 941193015062 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 941193015063 spermidine synthase; Provisional; Region: PRK00811 941193015064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193015065 S-adenosylmethionine binding site [chemical binding]; other site 941193015066 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 941193015067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193015068 active site 941193015069 phosphorylation site [posttranslational modification] 941193015070 intermolecular recognition site; other site 941193015071 dimerization interface [polypeptide binding]; other site 941193015072 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193015073 DNA binding site [nucleotide binding] 941193015074 sensor protein QseC; Provisional; Region: PRK10337 941193015075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193015076 dimer interface [polypeptide binding]; other site 941193015077 phosphorylation site [posttranslational modification] 941193015078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193015079 ATP binding site [chemical binding]; other site 941193015080 Mg2+ binding site [ion binding]; other site 941193015081 G-X-G motif; other site 941193015082 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 941193015083 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 941193015084 DNA binding residues [nucleotide binding] 941193015085 dimer interface [polypeptide binding]; other site 941193015086 copper binding site [ion binding]; other site 941193015087 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 941193015088 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 941193015089 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 941193015090 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 941193015091 ATP binding site [chemical binding]; other site 941193015092 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 941193015093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193015094 active site 941193015095 phosphorylation site [posttranslational modification] 941193015096 intermolecular recognition site; other site 941193015097 dimerization interface [polypeptide binding]; other site 941193015098 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941193015099 Zn2+ binding site [ion binding]; other site 941193015100 Mg2+ binding site [ion binding]; other site 941193015101 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 941193015102 EamA-like transporter family; Region: EamA; pfam00892 941193015103 EamA-like transporter family; Region: EamA; pfam00892 941193015104 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941193015105 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941193015106 putative DNA binding site [nucleotide binding]; other site 941193015107 putative Zn2+ binding site [ion binding]; other site 941193015108 AsnC family; Region: AsnC_trans_reg; pfam01037 941193015109 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 941193015110 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 941193015111 dimer interface [polypeptide binding]; other site 941193015112 active site 941193015113 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 941193015114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193015115 NAD(P) binding site [chemical binding]; other site 941193015116 active site 941193015117 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 941193015118 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941193015119 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193015120 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 941193015121 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 941193015122 active site 2 [active] 941193015123 active site 1 [active] 941193015124 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 941193015125 homodimer interface [polypeptide binding]; other site 941193015126 chemical substrate binding site [chemical binding]; other site 941193015127 oligomer interface [polypeptide binding]; other site 941193015128 metal binding site [ion binding]; metal-binding site 941193015129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193015130 S-adenosylmethionine binding site [chemical binding]; other site 941193015131 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 941193015132 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 941193015133 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 941193015134 putative active site [active] 941193015135 catalytic site [active] 941193015136 putative metal binding site [ion binding]; other site 941193015137 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 941193015138 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 941193015139 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941193015140 Coenzyme A binding pocket [chemical binding]; other site 941193015141 Predicted peroxiredoxins [General function prediction only]; Region: COG2044 941193015142 glycine cleavage system protein H; Provisional; Region: PRK13380 941193015143 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 941193015144 lipoyl attachment site [posttranslational modification]; other site 941193015145 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 941193015146 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 941193015147 AAA domain; Region: AAA_17; pfam13207 941193015148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193015149 S-adenosylmethionine binding site [chemical binding]; other site 941193015150 Predicted amidohydrolase [General function prediction only]; Region: COG0388 941193015151 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 941193015152 active site 941193015153 catalytic triad [active] 941193015154 dimer interface [polypeptide binding]; other site 941193015155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193015156 S-adenosylmethionine binding site [chemical binding]; other site 941193015157 Amino acid permease; Region: AA_permease; pfam00324 941193015158 hypothetical protein; Provisional; Region: PRK07036 941193015159 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941193015160 inhibitor-cofactor binding pocket; inhibition site 941193015161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193015162 catalytic residue [active] 941193015163 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941193015164 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941193015165 DNA binding residues [nucleotide binding] 941193015166 dimerization interface [polypeptide binding]; other site 941193015167 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 941193015168 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 941193015169 G1 box; other site 941193015170 putative GEF interaction site [polypeptide binding]; other site 941193015171 GTP/Mg2+ binding site [chemical binding]; other site 941193015172 Switch I region; other site 941193015173 G2 box; other site 941193015174 G3 box; other site 941193015175 Switch II region; other site 941193015176 G4 box; other site 941193015177 G5 box; other site 941193015178 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 941193015179 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 941193015180 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 941193015181 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 941193015182 selenocysteine synthase; Provisional; Region: PRK04311 941193015183 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 941193015184 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941193015185 catalytic residue [active] 941193015186 Uncharacterized protein involved in formate dehydrogenase formation [Posttranslational modification, protein turnover, chaperones]; Region: FdhE; COG3058 941193015187 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 941193015188 Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864 941193015189 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 941193015190 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 941193015191 4Fe-4S binding domain; Region: Fer4; cl02805 941193015192 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 941193015193 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 941193015194 molybdopterin cofactor binding site; other site 941193015195 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 941193015196 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 941193015197 molybdopterin cofactor binding site; other site 941193015198 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 941193015199 Lipase (class 2); Region: Lipase_2; pfam01674 941193015200 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 941193015201 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 941193015202 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 941193015203 active site 941193015204 FMN binding site [chemical binding]; other site 941193015205 2,4-decadienoyl-CoA binding site; other site 941193015206 catalytic residue [active] 941193015207 4Fe-4S cluster binding site [ion binding]; other site 941193015208 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 941193015209 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941193015210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 941193015211 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 941193015212 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 941193015213 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 941193015214 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 941193015215 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 941193015216 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 941193015217 Ligand binding site; other site 941193015218 Putative Catalytic site; other site 941193015219 DXD motif; other site 941193015220 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 941193015221 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 941193015222 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 941193015223 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 941193015224 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 941193015225 PhoU domain; Region: PhoU; pfam01895 941193015226 magnesium-transporting ATPase; Provisional; Region: PRK15122 941193015227 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 941193015228 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941193015229 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 941193015230 Soluble P-type ATPase [General function prediction only]; Region: COG4087 941193015231 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 941193015232 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 941193015233 Predicted membrane protein (DUF2214); Region: DUF2214; cl01427 941193015234 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 941193015235 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115 941193015236 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941193015237 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 941193015238 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 941193015239 CoenzymeA binding site [chemical binding]; other site 941193015240 subunit interaction site [polypeptide binding]; other site 941193015241 PHB binding site; other site 941193015242 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193015243 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193015244 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 941193015245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193015246 NAD(P) binding site [chemical binding]; other site 941193015247 active site 941193015248 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 941193015249 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 941193015250 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 941193015251 EamA-like transporter family; Region: EamA; pfam00892 941193015252 EamA-like transporter family; Region: EamA; pfam00892 941193015253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 941193015254 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 941193015255 Methyltransferase domain; Region: Methyltransf_31; pfam13847 941193015256 Nicotianamine synthase protein; Region: NAS; cl17658 941193015257 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 941193015258 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941193015259 N-terminal plug; other site 941193015260 ligand-binding site [chemical binding]; other site 941193015261 Predicted membrane protein [Function unknown]; Region: COG3503 941193015262 arginine decarboxylase; Provisional; Region: PRK05354 941193015263 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 941193015264 dimer interface [polypeptide binding]; other site 941193015265 active site 941193015266 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941193015267 catalytic residues [active] 941193015268 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 941193015269 translation initiation factor Sui1; Validated; Region: PRK06824 941193015270 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 941193015271 putative rRNA binding site [nucleotide binding]; other site 941193015272 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 941193015273 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 941193015274 nudix motif; other site 941193015275 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095 941193015276 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 941193015277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193015278 active site 941193015279 phosphorylation site [posttranslational modification] 941193015280 intermolecular recognition site; other site 941193015281 dimerization interface [polypeptide binding]; other site 941193015282 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193015283 metal binding site [ion binding]; metal-binding site 941193015284 active site 941193015285 I-site; other site 941193015286 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941193015287 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193015288 dimer interface [polypeptide binding]; other site 941193015289 putative CheW interface [polypeptide binding]; other site 941193015290 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 941193015291 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 941193015292 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 941193015293 DsbD alpha interface [polypeptide binding]; other site 941193015294 catalytic residues [active] 941193015295 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 941193015296 Dehydroquinase class II; Region: DHquinase_II; pfam01220 941193015297 active site 941193015298 trimer interface [polypeptide binding]; other site 941193015299 dimer interface [polypeptide binding]; other site 941193015300 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 941193015301 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 941193015302 carboxyltransferase (CT) interaction site; other site 941193015303 biotinylation site [posttranslational modification]; other site 941193015304 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 941193015305 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 941193015306 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 941193015307 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 941193015308 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 941193015309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193015310 S-adenosylmethionine binding site [chemical binding]; other site 941193015311 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 941193015312 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 941193015313 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 941193015314 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 941193015315 FMN binding site [chemical binding]; other site 941193015316 active site 941193015317 catalytic residues [active] 941193015318 substrate binding site [chemical binding]; other site 941193015319 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 941193015320 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 941193015321 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 941193015322 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 941193015323 purine monophosphate binding site [chemical binding]; other site 941193015324 dimer interface [polypeptide binding]; other site 941193015325 putative catalytic residues [active] 941193015326 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 941193015327 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 941193015328 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 941193015329 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 941193015330 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 941193015331 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 941193015332 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 941193015333 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 941193015334 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193015335 dimer interface [polypeptide binding]; other site 941193015336 phosphorylation site [posttranslational modification] 941193015337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193015338 ATP binding site [chemical binding]; other site 941193015339 Mg2+ binding site [ion binding]; other site 941193015340 G-X-G motif; other site 941193015341 Response regulator receiver domain; Region: Response_reg; pfam00072 941193015342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193015343 active site 941193015344 phosphorylation site [posttranslational modification] 941193015345 intermolecular recognition site; other site 941193015346 dimerization interface [polypeptide binding]; other site 941193015347 Response regulator receiver domain; Region: Response_reg; pfam00072 941193015348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193015349 active site 941193015350 phosphorylation site [posttranslational modification] 941193015351 intermolecular recognition site; other site 941193015352 dimerization interface [polypeptide binding]; other site 941193015353 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 941193015354 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 941193015355 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 941193015356 putative ligand binding site [chemical binding]; other site 941193015357 HEAT repeats; Region: HEAT_2; pfam13646 941193015358 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 941193015359 TM-ABC transporter signature motif; other site 941193015360 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 941193015361 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941193015362 TM-ABC transporter signature motif; other site 941193015363 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 941193015364 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 941193015365 Walker A/P-loop; other site 941193015366 ATP binding site [chemical binding]; other site 941193015367 Q-loop/lid; other site 941193015368 ABC transporter signature motif; other site 941193015369 Walker B; other site 941193015370 D-loop; other site 941193015371 H-loop/switch region; other site 941193015372 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 941193015373 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 941193015374 Walker A/P-loop; other site 941193015375 ATP binding site [chemical binding]; other site 941193015376 Q-loop/lid; other site 941193015377 ABC transporter signature motif; other site 941193015378 Walker B; other site 941193015379 D-loop; other site 941193015380 H-loop/switch region; other site 941193015381 putative acetyltransferase; Provisional; Region: PRK03624 941193015382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941193015383 Coenzyme A binding pocket [chemical binding]; other site 941193015384 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 941193015385 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 941193015386 alpha-gamma subunit interface [polypeptide binding]; other site 941193015387 beta-gamma subunit interface [polypeptide binding]; other site 941193015388 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 941193015389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941193015390 Coenzyme A binding pocket [chemical binding]; other site 941193015391 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 941193015392 gamma-beta subunit interface [polypeptide binding]; other site 941193015393 alpha-beta subunit interface [polypeptide binding]; other site 941193015394 urease subunit alpha; Reviewed; Region: ureC; PRK13207 941193015395 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 941193015396 subunit interactions [polypeptide binding]; other site 941193015397 active site 941193015398 flap region; other site 941193015399 hypothetical protein; Provisional; Region: PRK11019 941193015400 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 941193015401 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 941193015402 tetramer interface [polypeptide binding]; other site 941193015403 active site 941193015404 Mg2+/Mn2+ binding site [ion binding]; other site 941193015405 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 941193015406 putative chaperone; Provisional; Region: PRK11678 941193015407 nucleotide binding site [chemical binding]; other site 941193015408 putative NEF/HSP70 interaction site [polypeptide binding]; other site 941193015409 SBD interface [polypeptide binding]; other site 941193015410 psiF repeat; Region: PsiF_repeat; pfam07769 941193015411 psiF repeat; Region: PsiF_repeat; pfam07769 941193015412 psiF repeat; Region: PsiF_repeat; pfam07769 941193015413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 941193015414 MOSC domain; Region: MOSC; pfam03473 941193015415 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 941193015416 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 941193015417 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 941193015418 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 941193015419 DNA binding residues [nucleotide binding] 941193015420 drug binding residues [chemical binding]; other site 941193015421 dimer interface [polypeptide binding]; other site 941193015422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 941193015423 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 941193015424 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 941193015425 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 941193015426 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 941193015427 dinuclear metal binding motif [ion binding]; other site 941193015428 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 941193015429 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 941193015430 Moco binding site; other site 941193015431 metal coordination site [ion binding]; other site 941193015432 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 941193015433 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 941193015434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193015435 active site 941193015436 phosphorylation site [posttranslational modification] 941193015437 intermolecular recognition site; other site 941193015438 dimerization interface [polypeptide binding]; other site 941193015439 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193015440 DNA binding site [nucleotide binding] 941193015441 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 941193015442 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193015443 dimerization interface [polypeptide binding]; other site 941193015444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193015445 dimer interface [polypeptide binding]; other site 941193015446 phosphorylation site [posttranslational modification] 941193015447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193015448 ATP binding site [chemical binding]; other site 941193015449 Mg2+ binding site [ion binding]; other site 941193015450 G-X-G motif; other site 941193015451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193015452 putative MFS family transporter protein; Provisional; Region: PRK03633 941193015453 putative substrate translocation pore; other site 941193015454 Fatty acid desaturase; Region: FA_desaturase; pfam00487 941193015455 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 941193015456 putative di-iron ligands [ion binding]; other site 941193015457 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 941193015458 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 941193015459 FAD binding pocket [chemical binding]; other site 941193015460 FAD binding motif [chemical binding]; other site 941193015461 phosphate binding motif [ion binding]; other site 941193015462 beta-alpha-beta structure motif; other site 941193015463 NAD binding pocket [chemical binding]; other site 941193015464 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941193015465 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 941193015466 catalytic loop [active] 941193015467 iron binding site [ion binding]; other site 941193015468 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 941193015469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193015470 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 941193015471 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 941193015472 dimer interface [polypeptide binding]; other site 941193015473 catalytic residues [active] 941193015474 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 941193015475 UreF; Region: UreF; pfam01730 941193015476 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 941193015477 G1 box; other site 941193015478 GTP/Mg2+ binding site [chemical binding]; other site 941193015479 G2 box; other site 941193015480 Switch I region; other site 941193015481 G3 box; other site 941193015482 Switch II region; other site 941193015483 G4 box; other site 941193015484 G5 box; other site 941193015485 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 941193015486 FecR protein; Region: FecR; pfam04773 941193015487 RNA polymerase sigma factor; Provisional; Region: PRK12529 941193015488 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941193015489 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941193015490 DNA binding residues [nucleotide binding] 941193015491 Secretin and TonB N terminus short domain; Region: STN; smart00965 941193015492 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 941193015493 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 941193015494 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 941193015495 outer membrane porin, OprD family; Region: OprD; pfam03573 941193015496 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 941193015497 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 941193015498 NAD(P) binding site [chemical binding]; other site 941193015499 catalytic residues [active] 941193015500 benzoate transport; Region: 2A0115; TIGR00895 941193015501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193015502 putative substrate translocation pore; other site 941193015503 benzoylformate decarboxylase; Reviewed; Region: PRK07092 941193015504 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 941193015505 PYR/PP interface [polypeptide binding]; other site 941193015506 dimer interface [polypeptide binding]; other site 941193015507 TPP binding site [chemical binding]; other site 941193015508 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 941193015509 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 941193015510 TPP-binding site [chemical binding]; other site 941193015511 dimer interface [polypeptide binding]; other site 941193015512 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193015513 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193015514 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 941193015515 substrate binding pocket [chemical binding]; other site 941193015516 dimerization interface [polypeptide binding]; other site 941193015517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193015518 putative substrate translocation pore; other site 941193015519 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 941193015520 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 941193015521 iron-sulfur cluster [ion binding]; other site 941193015522 [2Fe-2S] cluster binding site [ion binding]; other site 941193015523 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 941193015524 alpha subunit interface [polypeptide binding]; other site 941193015525 active site 941193015526 substrate binding site [chemical binding]; other site 941193015527 Fe binding site [ion binding]; other site 941193015528 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 941193015529 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 941193015530 FMN-binding pocket [chemical binding]; other site 941193015531 flavin binding motif; other site 941193015532 phosphate binding motif [ion binding]; other site 941193015533 beta-alpha-beta structure motif; other site 941193015534 NAD binding pocket [chemical binding]; other site 941193015535 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941193015536 catalytic loop [active] 941193015537 iron binding site [ion binding]; other site 941193015538 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193015539 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 941193015540 DNA-binding site [nucleotide binding]; DNA binding site 941193015541 FCD domain; Region: FCD; pfam07729 941193015542 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 941193015543 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 941193015544 putative NAD(P) binding site [chemical binding]; other site 941193015545 homodimer interface [polypeptide binding]; other site 941193015546 homotetramer interface [polypeptide binding]; other site 941193015547 active site 941193015548 ornithine cyclodeaminase; Validated; Region: PRK06141 941193015549 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 941193015550 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 941193015551 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 941193015552 Walker A/P-loop; other site 941193015553 ATP binding site [chemical binding]; other site 941193015554 Q-loop/lid; other site 941193015555 ABC transporter signature motif; other site 941193015556 Walker B; other site 941193015557 D-loop; other site 941193015558 H-loop/switch region; other site 941193015559 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 941193015560 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 941193015561 Walker A/P-loop; other site 941193015562 ATP binding site [chemical binding]; other site 941193015563 Q-loop/lid; other site 941193015564 ABC transporter signature motif; other site 941193015565 Walker B; other site 941193015566 D-loop; other site 941193015567 H-loop/switch region; other site 941193015568 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 941193015569 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 941193015570 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 941193015571 TM-ABC transporter signature motif; other site 941193015572 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941193015573 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 941193015574 TM-ABC transporter signature motif; other site 941193015575 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 941193015576 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 941193015577 dimerization interface [polypeptide binding]; other site 941193015578 ligand binding site [chemical binding]; other site 941193015579 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 941193015580 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193015581 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193015582 dimerization interface [polypeptide binding]; other site 941193015583 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 941193015584 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193015585 dimerization interface [polypeptide binding]; other site 941193015586 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941193015587 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193015588 dimer interface [polypeptide binding]; other site 941193015589 putative CheW interface [polypeptide binding]; other site 941193015590 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 941193015591 nudix motif; other site 941193015592 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 941193015593 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 941193015594 active site 941193015595 nucleotide binding site [chemical binding]; other site 941193015596 HIGH motif; other site 941193015597 KMSKS motif; other site 941193015598 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 941193015599 Isochorismatase family; Region: Isochorismatase; pfam00857 941193015600 catalytic triad [active] 941193015601 metal binding site [ion binding]; metal-binding site 941193015602 conserved cis-peptide bond; other site 941193015603 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 941193015604 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 941193015605 active site 941193015606 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 941193015607 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 941193015608 homodimer interface [polypeptide binding]; other site 941193015609 NAD binding pocket [chemical binding]; other site 941193015610 ATP binding pocket [chemical binding]; other site 941193015611 Mg binding site [ion binding]; other site 941193015612 active-site loop [active] 941193015613 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 941193015614 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 941193015615 active site 941193015616 catalytic triad [active] 941193015617 oxyanion hole [active] 941193015618 Azurin [Energy production and conversion]; Region: COG3241 941193015619 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 941193015620 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941193015621 Peptidase family M23; Region: Peptidase_M23; pfam01551 941193015622 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 941193015623 Mechanosensitive ion channel; Region: MS_channel; pfam00924 941193015624 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 941193015625 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 941193015626 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 941193015627 Uncharacterized conserved protein [Function unknown]; Region: COG2308 941193015628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 941193015629 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 941193015630 hypothetical protein; Provisional; Region: PRK01254 941193015631 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 941193015632 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 941193015633 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 941193015634 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 941193015635 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193015636 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193015637 metal binding site [ion binding]; metal-binding site 941193015638 active site 941193015639 I-site; other site 941193015640 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 941193015641 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 941193015642 active site 941193015643 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941193015644 substrate binding site [chemical binding]; other site 941193015645 catalytic residues [active] 941193015646 dimer interface [polypeptide binding]; other site 941193015647 replicative DNA helicase; Provisional; Region: PRK05748 941193015648 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 941193015649 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 941193015650 Walker A motif; other site 941193015651 ATP binding site [chemical binding]; other site 941193015652 Walker B motif; other site 941193015653 DNA binding loops [nucleotide binding] 941193015654 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 941193015655 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 941193015656 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 941193015657 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 941193015658 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 941193015659 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 941193015660 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 941193015661 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 941193015662 exoribonuclease R; Provisional; Region: PRK11642 941193015663 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 941193015664 RNB domain; Region: RNB; pfam00773 941193015665 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 941193015666 RNA binding site [nucleotide binding]; other site 941193015667 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 941193015668 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 941193015669 GDP-binding site [chemical binding]; other site 941193015670 ACT binding site; other site 941193015671 IMP binding site; other site 941193015672 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 941193015673 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 941193015674 dimer interface [polypeptide binding]; other site 941193015675 motif 1; other site 941193015676 active site 941193015677 motif 2; other site 941193015678 motif 3; other site 941193015679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 941193015680 FtsH protease regulator HflC; Provisional; Region: PRK11029 941193015681 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 941193015682 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 941193015683 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 941193015684 HflK protein; Region: hflK; TIGR01933 941193015685 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 941193015686 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 941193015687 HflX GTPase family; Region: HflX; cd01878 941193015688 G1 box; other site 941193015689 GTP/Mg2+ binding site [chemical binding]; other site 941193015690 Switch I region; other site 941193015691 G2 box; other site 941193015692 G3 box; other site 941193015693 Switch II region; other site 941193015694 G4 box; other site 941193015695 G5 box; other site 941193015696 bacterial Hfq-like; Region: Hfq; cd01716 941193015697 hexamer interface [polypeptide binding]; other site 941193015698 Sm1 motif; other site 941193015699 RNA binding site [nucleotide binding]; other site 941193015700 Sm2 motif; other site 941193015701 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 941193015702 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 941193015703 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 941193015704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193015705 ATP binding site [chemical binding]; other site 941193015706 Mg2+ binding site [ion binding]; other site 941193015707 G-X-G motif; other site 941193015708 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 941193015709 ATP binding site [chemical binding]; other site 941193015710 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 941193015711 AMIN domain; Region: AMIN; pfam11741 941193015712 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 941193015713 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 941193015714 active site 941193015715 metal binding site [ion binding]; metal-binding site 941193015716 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 941193015717 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941193015718 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 941193015719 putative carbohydrate kinase; Provisional; Region: PRK10565 941193015720 Uncharacterized conserved protein [Function unknown]; Region: COG0062 941193015721 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 941193015722 putative substrate binding site [chemical binding]; other site 941193015723 putative ATP binding site [chemical binding]; other site 941193015724 epoxyqueuosine reductase; Region: TIGR00276 941193015725 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 941193015726 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 941193015727 catalytic site [active] 941193015728 putative active site [active] 941193015729 putative substrate binding site [chemical binding]; other site 941193015730 dimer interface [polypeptide binding]; other site 941193015731 GTPase RsgA; Reviewed; Region: PRK12288 941193015732 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 941193015733 RNA binding site [nucleotide binding]; other site 941193015734 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 941193015735 GTPase/Zn-binding domain interface [polypeptide binding]; other site 941193015736 GTP/Mg2+ binding site [chemical binding]; other site 941193015737 G4 box; other site 941193015738 G5 box; other site 941193015739 G1 box; other site 941193015740 Switch I region; other site 941193015741 G2 box; other site 941193015742 G3 box; other site 941193015743 Switch II region; other site 941193015744 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 941193015745 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 941193015746 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 941193015747 ligand binding site [chemical binding]; other site 941193015748 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 941193015749 flagellar motor protein MotA; Validated; Region: PRK09110 941193015750 HDOD domain; Region: HDOD; pfam08668 941193015751 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 941193015752 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 941193015753 active site residue [active] 941193015754 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 941193015755 active site residue [active] 941193015756 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 941193015757 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 941193015758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 941193015759 active site 941193015760 phosphorylation site [posttranslational modification] 941193015761 dimerization interface [polypeptide binding]; other site 941193015762 PAS fold; Region: PAS; pfam00989 941193015763 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193015764 putative active site [active] 941193015765 heme pocket [chemical binding]; other site 941193015766 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193015767 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193015768 metal binding site [ion binding]; metal-binding site 941193015769 active site 941193015770 I-site; other site 941193015771 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941193015772 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 941193015773 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 941193015774 phosphoserine phosphatase SerB; Region: serB; TIGR00338 941193015775 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941193015776 motif II; other site 941193015777 Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726 941193015778 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 941193015779 metal binding site [ion binding]; metal-binding site 941193015780 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 941193015781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 941193015782 Protein of unknown function (DUF330); Region: DUF330; pfam03886 941193015783 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 941193015784 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 941193015785 CAP-like domain; other site 941193015786 active site 941193015787 primary dimer interface [polypeptide binding]; other site 941193015788 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 941193015789 catalytic motif [active] 941193015790 Catalytic residue [active] 941193015791 SdiA-regulated; Region: SdiA-regulated; cd09971 941193015792 putative active site [active] 941193015793 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 941193015794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193015795 ATP binding site [chemical binding]; other site 941193015796 Mg2+ binding site [ion binding]; other site 941193015797 G-X-G motif; other site 941193015798 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 941193015799 anchoring element; other site 941193015800 dimer interface [polypeptide binding]; other site 941193015801 ATP binding site [chemical binding]; other site 941193015802 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 941193015803 active site 941193015804 metal binding site [ion binding]; metal-binding site 941193015805 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 941193015806 Predicted esterase [General function prediction only]; Region: COG3150 941193015807 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 941193015808 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 941193015809 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 941193015810 active site 941193015811 metal binding site [ion binding]; metal-binding site 941193015812 hexamer interface [polypeptide binding]; other site 941193015813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3151 941193015814 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 941193015815 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 941193015816 dimer interface [polypeptide binding]; other site 941193015817 ADP-ribose binding site [chemical binding]; other site 941193015818 active site 941193015819 nudix motif; other site 941193015820 metal binding site [ion binding]; metal-binding site 941193015821 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 941193015822 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 941193015823 ThiC-associated domain; Region: ThiC-associated; pfam13667 941193015824 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 941193015825 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 941193015826 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 941193015827 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941193015828 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 941193015829 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941193015830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193015831 homodimer interface [polypeptide binding]; other site 941193015832 catalytic residue [active] 941193015833 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 941193015834 CoA binding domain; Region: CoA_binding_2; pfam13380 941193015835 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 941193015836 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 941193015837 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941193015838 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193015839 active site 941193015840 enoyl-CoA hydratase; Provisional; Region: PRK06688 941193015841 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941193015842 substrate binding site [chemical binding]; other site 941193015843 oxyanion hole (OAH) forming residues; other site 941193015844 trimer interface [polypeptide binding]; other site 941193015845 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 941193015846 S-methylmethionine transporter; Provisional; Region: PRK11387 941193015847 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941193015848 HAMP domain; Region: HAMP; pfam00672 941193015849 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193015850 dimer interface [polypeptide binding]; other site 941193015851 phosphorylation site [posttranslational modification] 941193015852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193015853 ATP binding site [chemical binding]; other site 941193015854 Mg2+ binding site [ion binding]; other site 941193015855 G-X-G motif; other site 941193015856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193015857 Response regulator receiver domain; Region: Response_reg; pfam00072 941193015858 active site 941193015859 phosphorylation site [posttranslational modification] 941193015860 intermolecular recognition site; other site 941193015861 dimerization interface [polypeptide binding]; other site 941193015862 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 941193015863 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193015864 substrate binding pocket [chemical binding]; other site 941193015865 membrane-bound complex binding site; other site 941193015866 hinge residues; other site 941193015867 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 941193015868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193015869 active site 941193015870 phosphorylation site [posttranslational modification] 941193015871 intermolecular recognition site; other site 941193015872 dimerization interface [polypeptide binding]; other site 941193015873 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193015874 DNA binding site [nucleotide binding] 941193015875 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 941193015876 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193015877 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 941193015878 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 941193015879 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941193015880 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 941193015881 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 941193015882 putative active site [active] 941193015883 putative FMN binding site [chemical binding]; other site 941193015884 putative substrate binding site [chemical binding]; other site 941193015885 putative catalytic residue [active] 941193015886 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 941193015887 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941193015888 non-specific DNA binding site [nucleotide binding]; other site 941193015889 salt bridge; other site 941193015890 sequence-specific DNA binding site [nucleotide binding]; other site 941193015891 Cupin domain; Region: Cupin_2; pfam07883 941193015892 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 941193015893 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 941193015894 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 941193015895 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193015896 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193015897 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941193015898 dimerization interface [polypeptide binding]; other site 941193015899 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 941193015900 FAD dependent oxidoreductase; Region: DAO; pfam01266 941193015901 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941193015902 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 941193015903 active site 941193015904 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 941193015905 catalytic tetrad [active] 941193015906 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941193015907 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193015908 active site 941193015909 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941193015910 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193015911 active site 941193015912 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 941193015913 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 941193015914 dimer interface [polypeptide binding]; other site 941193015915 active site 941193015916 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 941193015917 Ligand Binding Site [chemical binding]; other site 941193015918 Molecular Tunnel; other site 941193015919 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 941193015920 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 941193015921 putative ribose interaction site [chemical binding]; other site 941193015922 putative ADP binding site [chemical binding]; other site 941193015923 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 941193015924 active site 941193015925 nucleotide binding site [chemical binding]; other site 941193015926 HIGH motif; other site 941193015927 KMSKS motif; other site 941193015928 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 941193015929 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941193015930 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 941193015931 Walker A/P-loop; other site 941193015932 ATP binding site [chemical binding]; other site 941193015933 Q-loop/lid; other site 941193015934 ABC transporter signature motif; other site 941193015935 Walker B; other site 941193015936 D-loop; other site 941193015937 H-loop/switch region; other site 941193015938 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 941193015939 active site 941193015940 substrate binding site [chemical binding]; other site 941193015941 ATP binding site [chemical binding]; other site 941193015942 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 941193015943 O-Antigen ligase; Region: Wzy_C; pfam04932 941193015944 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 941193015945 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 941193015946 active site 941193015947 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941193015948 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 941193015949 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 941193015950 Mig-14; Region: Mig-14; pfam07395 941193015951 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 941193015952 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 941193015953 putative ADP-binding pocket [chemical binding]; other site 941193015954 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941193015955 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 941193015956 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 941193015957 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 941193015958 active site 941193015959 ATP binding site [chemical binding]; other site 941193015960 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 941193015961 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293 941193015962 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 941193015963 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 941193015964 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941193015965 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 941193015966 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 941193015967 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 941193015968 putative active site [active] 941193015969 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 941193015970 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 941193015971 putative active site [active] 941193015972 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 941193015973 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 941193015974 homodimer interface [polypeptide binding]; other site 941193015975 substrate-cofactor binding pocket; other site 941193015976 catalytic residue [active] 941193015977 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 941193015978 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 941193015979 metal binding triad; other site 941193015980 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 941193015981 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 941193015982 metal binding triad; other site 941193015983 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 941193015984 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 941193015985 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 941193015986 dimer interface [polypeptide binding]; other site 941193015987 TPP-binding site [chemical binding]; other site 941193015988 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 941193015989 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_long; TIGR01348 941193015990 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 941193015991 E3 interaction surface; other site 941193015992 lipoyl attachment site [posttranslational modification]; other site 941193015993 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 941193015994 E3 interaction surface; other site 941193015995 lipoyl attachment site [posttranslational modification]; other site 941193015996 e3 binding domain; Region: E3_binding; pfam02817 941193015997 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 941193015998 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 941193015999 GAF domain; Region: GAF; pfam01590 941193016000 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193016001 PAS domain; Region: PAS_9; pfam13426 941193016002 putative active site [active] 941193016003 heme pocket [chemical binding]; other site 941193016004 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193016005 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193016006 metal binding site [ion binding]; metal-binding site 941193016007 active site 941193016008 I-site; other site 941193016009 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941193016010 methionine sulfoxide reductase A; Provisional; Region: PRK00058 941193016011 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 941193016012 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 941193016013 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 941193016014 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193016015 active site 941193016016 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 941193016017 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 941193016018 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 941193016019 TrkA-C domain; Region: TrkA_C; pfam02080 941193016020 Transporter associated domain; Region: CorC_HlyC; smart01091 941193016021 hypothetical protein; Provisional; Region: PRK11281 941193016022 Vegetative insecticide protein 3A N terminal; Region: Vip3A_N; pfam12495 941193016023 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 941193016024 Mechanosensitive ion channel; Region: MS_channel; pfam00924 941193016025 Uncharacterized conserved protein [Function unknown]; Region: COG0397 941193016026 hypothetical protein; Validated; Region: PRK00029 941193016027 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 941193016028 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 941193016029 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 941193016030 homodimer interface [polypeptide binding]; other site 941193016031 substrate-cofactor binding pocket; other site 941193016032 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193016033 catalytic residue [active] 941193016034 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 941193016035 CoenzymeA binding site [chemical binding]; other site 941193016036 subunit interaction site [polypeptide binding]; other site 941193016037 PHB binding site; other site 941193016038 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 941193016039 Ligand Binding Site [chemical binding]; other site 941193016040 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 941193016041 Ligand Binding Site [chemical binding]; other site 941193016042 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 941193016043 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 941193016044 P-loop; other site 941193016045 Magnesium ion binding site [ion binding]; other site 941193016046 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 941193016047 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 941193016048 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193016049 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 941193016050 dimerization interface [polypeptide binding]; other site 941193016051 substrate binding pocket [chemical binding]; other site 941193016052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193016053 putative substrate translocation pore; other site 941193016054 short chain dehydrogenase; Provisional; Region: PRK06197 941193016055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193016056 NAD(P) binding site [chemical binding]; other site 941193016057 active site 941193016058 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 941193016059 Helix-turn-helix domain; Region: HTH_18; pfam12833 941193016060 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193016061 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 941193016062 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 941193016063 substrate binding site [chemical binding]; other site 941193016064 active site 941193016065 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 941193016066 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941193016067 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941193016068 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 941193016069 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 941193016070 active site 941193016071 dimer interface [polypeptide binding]; other site 941193016072 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 941193016073 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 941193016074 active site 941193016075 FMN binding site [chemical binding]; other site 941193016076 substrate binding site [chemical binding]; other site 941193016077 3Fe-4S cluster binding site [ion binding]; other site 941193016078 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 941193016079 domain interface; other site 941193016080 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 941193016081 AAA ATPase domain; Region: AAA_16; pfam13191 941193016082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 941193016083 Sporulation related domain; Region: SPOR; pfam05036 941193016084 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 941193016085 active site 941193016086 dimer interface [polypeptide binding]; other site 941193016087 metal binding site [ion binding]; metal-binding site 941193016088 shikimate kinase; Reviewed; Region: aroK; PRK00131 941193016089 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 941193016090 ADP binding site [chemical binding]; other site 941193016091 magnesium binding site [ion binding]; other site 941193016092 putative shikimate binding site; other site 941193016093 Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796 941193016094 AMIN domain; Region: AMIN; pfam11741 941193016095 Secretin and TonB N terminus short domain; Region: STN; smart00965 941193016096 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 941193016097 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 941193016098 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 941193016099 Pilus assembly protein, PilP; Region: PilP; pfam04351 941193016100 Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilO; COG3167 941193016101 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 941193016102 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 941193016103 Competence protein A; Region: Competence_A; pfam11104 941193016104 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 941193016105 nucleotide binding site [chemical binding]; other site 941193016106 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 941193016107 Transglycosylase; Region: Transgly; pfam00912 941193016108 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 941193016109 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 941193016110 Malic enzyme, N-terminal domain; Region: malic; pfam00390 941193016111 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 941193016112 putative NAD(P) binding site [chemical binding]; other site 941193016113 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 941193016114 Peptidase family M48; Region: Peptidase_M48; pfam01435 941193016115 Staphylococcal nuclease homologues; Region: SNc; smart00318 941193016116 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 941193016117 Catalytic site; other site 941193016118 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 941193016119 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 941193016120 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941193016121 ATP binding site [chemical binding]; other site 941193016122 putative Mg++ binding site [ion binding]; other site 941193016123 helicase superfamily c-terminal domain; Region: HELICc; smart00490 941193016124 nucleotide binding region [chemical binding]; other site 941193016125 ATP-binding site [chemical binding]; other site 941193016126 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 941193016127 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 941193016128 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 941193016129 active site 941193016130 HIGH motif; other site 941193016131 KMSK motif region; other site 941193016132 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 941193016133 tRNA binding surface [nucleotide binding]; other site 941193016134 anticodon binding site; other site 941193016135 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 941193016136 Sporulation related domain; Region: SPOR; pfam05036 941193016137 ATP-dependent protease subunit HslV; Provisional; Region: PRK05456 941193016138 active site 941193016139 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 941193016140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193016141 Walker A motif; other site 941193016142 ATP binding site [chemical binding]; other site 941193016143 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 941193016144 Walker B motif; other site 941193016145 arginine finger; other site 941193016146 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 941193016147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 941193016148 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 941193016149 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 941193016150 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 941193016151 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 941193016152 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 941193016153 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 941193016154 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941193016155 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193016156 Bacterial transcriptional repressor; Region: TetR; pfam13972 941193016157 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 941193016158 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 941193016159 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 941193016160 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 941193016161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193016162 S-adenosylmethionine binding site [chemical binding]; other site 941193016163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 941193016164 SCP-2 sterol transfer family; Region: SCP2; pfam02036 941193016165 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 941193016166 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 941193016167 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 941193016168 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 941193016169 metal binding site [ion binding]; metal-binding site 941193016170 twin arginine translocase protein A; Provisional; Region: tatA; PRK00442 941193016171 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 941193016172 sec-independent translocase; Provisional; Region: tatB; PRK00404 941193016173 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 941193016174 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 941193016175 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 941193016176 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 941193016177 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941193016178 dimer interface [polypeptide binding]; other site 941193016179 putative CheW interface [polypeptide binding]; other site 941193016180 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 941193016181 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 941193016182 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 941193016183 Walker A/P-loop; other site 941193016184 ATP binding site [chemical binding]; other site 941193016185 Q-loop/lid; other site 941193016186 ABC transporter signature motif; other site 941193016187 Walker B; other site 941193016188 D-loop; other site 941193016189 H-loop/switch region; other site 941193016190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193016191 dimer interface [polypeptide binding]; other site 941193016192 conserved gate region; other site 941193016193 putative PBP binding loops; other site 941193016194 ABC-ATPase subunit interface; other site 941193016195 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941193016196 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193016197 substrate binding pocket [chemical binding]; other site 941193016198 membrane-bound complex binding site; other site 941193016199 hinge residues; other site 941193016200 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 941193016201 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 941193016202 Ligand binding site; other site 941193016203 DXD motif; other site 941193016204 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 941193016205 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 941193016206 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 941193016207 putative active site [active] 941193016208 dimerization interface [polypeptide binding]; other site 941193016209 putative tRNAtyr binding site [nucleotide binding]; other site 941193016210 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 941193016211 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 941193016212 TAP-like protein; Region: Abhydrolase_4; pfam08386 941193016213 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 941193016214 nudix motif; other site 941193016215 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941193016216 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193016217 substrate binding pocket [chemical binding]; other site 941193016218 membrane-bound complex binding site; other site 941193016219 hinge residues; other site 941193016220 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 941193016221 homotrimer interaction site [polypeptide binding]; other site 941193016222 putative active site [active] 941193016223 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 941193016224 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941193016225 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 941193016226 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193016227 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193016228 dimerization interface [polypeptide binding]; other site 941193016229 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 941193016230 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 941193016231 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 941193016232 putative active site [active] 941193016233 catalytic site [active] 941193016234 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 941193016235 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 941193016236 putative active site [active] 941193016237 catalytic site [active] 941193016238 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 941193016239 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 941193016240 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 941193016241 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 941193016242 N-formylglutamate amidohydrolase; Region: FGase; cl01522 941193016243 imidazolonepropionase; Validated; Region: PRK09356 941193016244 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 941193016245 active site 941193016246 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 941193016247 active sites [active] 941193016248 tetramer interface [polypeptide binding]; other site 941193016249 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 941193016250 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 941193016251 Walker A/P-loop; other site 941193016252 ATP binding site [chemical binding]; other site 941193016253 Q-loop/lid; other site 941193016254 ABC transporter signature motif; other site 941193016255 Walker B; other site 941193016256 D-loop; other site 941193016257 H-loop/switch region; other site 941193016258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193016259 dimer interface [polypeptide binding]; other site 941193016260 conserved gate region; other site 941193016261 putative PBP binding loops; other site 941193016262 ABC-ATPase subunit interface; other site 941193016263 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 941193016264 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 941193016265 putative proline-specific permease; Provisional; Region: proY; PRK10580 941193016266 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 941193016267 active sites [active] 941193016268 tetramer interface [polypeptide binding]; other site 941193016269 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 941193016270 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 941193016271 Na binding site [ion binding]; other site 941193016272 urocanate hydratase; Provisional; Region: PRK05414 941193016273 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 941193016274 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 941193016275 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 941193016276 putative di-iron ligands [ion binding]; other site 941193016277 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 941193016278 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 941193016279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758 941193016280 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 941193016281 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193016282 DNA-binding site [nucleotide binding]; DNA binding site 941193016283 UTRA domain; Region: UTRA; pfam07702 941193016284 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 941193016285 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 941193016286 active site 941193016287 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 941193016288 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 941193016289 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 941193016290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 941193016291 fructose-1,6-bisphosphatase family protein; Region: PLN02628 941193016292 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 941193016293 AMP binding site [chemical binding]; other site 941193016294 metal binding site [ion binding]; metal-binding site 941193016295 active site 941193016296 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 941193016297 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941193016298 dimer interface [polypeptide binding]; other site 941193016299 active site 941193016300 metal binding site [ion binding]; metal-binding site 941193016301 glutathione binding site [chemical binding]; other site 941193016302 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 941193016303 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 941193016304 active site 941193016305 catalytic triad [active] 941193016306 oxyanion hole [active] 941193016307 Autotransporter beta-domain; Region: Autotransporter; pfam03797 941193016308 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 941193016309 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 941193016310 Predicted membrane protein [Function unknown]; Region: COG5373 941193016311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193016312 S-adenosylmethionine binding site [chemical binding]; other site 941193016313 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 941193016314 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 941193016315 DNA binding residues [nucleotide binding] 941193016316 putative dimer interface [polypeptide binding]; other site 941193016317 putative metal binding residues [ion binding]; other site 941193016318 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 941193016319 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 941193016320 G1 box; other site 941193016321 putative GEF interaction site [polypeptide binding]; other site 941193016322 GTP/Mg2+ binding site [chemical binding]; other site 941193016323 Switch I region; other site 941193016324 G2 box; other site 941193016325 G3 box; other site 941193016326 Switch II region; other site 941193016327 G4 box; other site 941193016328 G5 box; other site 941193016329 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 941193016330 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 941193016331 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 941193016332 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 941193016333 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 941193016334 Ligand Binding Site [chemical binding]; other site 941193016335 thiazole biosynthesis domain; Region: ThiI_C_thiazole; TIGR04271 941193016336 glutamine synthetase; Provisional; Region: glnA; PRK09469 941193016337 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 941193016338 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 941193016339 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 941193016340 Mechanosensitive ion channel; Region: MS_channel; pfam00924 941193016341 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 941193016342 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 941193016343 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 941193016344 PAS domain; Region: PAS; smart00091 941193016345 putative active site [active] 941193016346 heme pocket [chemical binding]; other site 941193016347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193016348 dimer interface [polypeptide binding]; other site 941193016349 phosphorylation site [posttranslational modification] 941193016350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193016351 ATP binding site [chemical binding]; other site 941193016352 Mg2+ binding site [ion binding]; other site 941193016353 G-X-G motif; other site 941193016354 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 941193016355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193016356 active site 941193016357 phosphorylation site [posttranslational modification] 941193016358 intermolecular recognition site; other site 941193016359 dimerization interface [polypeptide binding]; other site 941193016360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193016361 Walker A motif; other site 941193016362 ATP binding site [chemical binding]; other site 941193016363 Walker B motif; other site 941193016364 arginine finger; other site 941193016365 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941193016366 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 941193016367 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 941193016368 SecA binding site; other site 941193016369 Preprotein binding site; other site 941193016370 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 941193016371 GSH binding site [chemical binding]; other site 941193016372 catalytic residues [active] 941193016373 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 941193016374 active site residue [active] 941193016375 phosphoglyceromutase; Provisional; Region: PRK05434 941193016376 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 941193016377 CAAX protease self-immunity; Region: Abi; pfam02517 941193016378 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 941193016379 Peptidase family M23; Region: Peptidase_M23; pfam01551 941193016380 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 941193016381 C-terminal peptidase (prc); Region: prc; TIGR00225 941193016382 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 941193016383 protein binding site [polypeptide binding]; other site 941193016384 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 941193016385 Catalytic dyad [active] 941193016386 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 941193016387 NodB motif; other site 941193016388 putative active site [active] 941193016389 putative catalytic site [active] 941193016390 Zn binding site [ion binding]; other site 941193016391 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 941193016392 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193016393 substrate binding pocket [chemical binding]; other site 941193016394 membrane-bound complex binding site; other site 941193016395 hinge residues; other site 941193016396 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193016397 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941193016398 substrate binding pocket [chemical binding]; other site 941193016399 membrane-bound complex binding site; other site 941193016400 hinge residues; other site 941193016401 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193016402 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941193016403 substrate binding pocket [chemical binding]; other site 941193016404 membrane-bound complex binding site; other site 941193016405 hinge residues; other site 941193016406 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 941193016407 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 941193016408 substrate binding site [chemical binding]; other site 941193016409 glutamase interaction surface [polypeptide binding]; other site 941193016410 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 941193016411 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 941193016412 catalytic residues [active] 941193016413 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 941193016414 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 941193016415 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 941193016416 putative active site [active] 941193016417 oxyanion strand; other site 941193016418 catalytic triad [active] 941193016419 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 941193016420 putative active site pocket [active] 941193016421 4-fold oligomerization interface [polypeptide binding]; other site 941193016422 metal binding residues [ion binding]; metal-binding site 941193016423 3-fold/trimer interface [polypeptide binding]; other site 941193016424 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 941193016425 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 941193016426 Predicted dehydrogenase [General function prediction only]; Region: COG0579 941193016427 hydroxyglutarate oxidase; Provisional; Region: PRK11728 941193016428 AsmA family; Region: AsmA; pfam05170 941193016429 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 941193016430 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 941193016431 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 941193016432 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 941193016433 minor groove reading motif; other site 941193016434 helix-hairpin-helix signature motif; other site 941193016435 substrate binding pocket [chemical binding]; other site 941193016436 active site 941193016437 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 941193016438 DNA binding and oxoG recognition site [nucleotide binding] 941193016439 oxidative damage protection protein; Provisional; Region: PRK05408 941193016440 putative oxidoreductase; Provisional; Region: PRK11579 941193016441 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 941193016442 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 941193016443 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 941193016444 classical (c) SDRs; Region: SDR_c; cd05233 941193016445 NAD(P) binding site [chemical binding]; other site 941193016446 active site 941193016447 Uncharacterized conserved protein [Function unknown]; Region: COG2928 941193016448 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 941193016449 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 941193016450 Walker A/P-loop; other site 941193016451 ATP binding site [chemical binding]; other site 941193016452 Q-loop/lid; other site 941193016453 ABC transporter signature motif; other site 941193016454 Walker B; other site 941193016455 D-loop; other site 941193016456 H-loop/switch region; other site 941193016457 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941193016458 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193016459 substrate binding pocket [chemical binding]; other site 941193016460 membrane-bound complex binding site; other site 941193016461 hinge residues; other site 941193016462 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 941193016463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193016464 dimer interface [polypeptide binding]; other site 941193016465 conserved gate region; other site 941193016466 putative PBP binding loops; other site 941193016467 ABC-ATPase subunit interface; other site 941193016468 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 941193016469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193016470 dimer interface [polypeptide binding]; other site 941193016471 conserved gate region; other site 941193016472 putative PBP binding loops; other site 941193016473 ABC-ATPase subunit interface; other site 941193016474 Methyltransferase domain; Region: Methyltransf_32; pfam13679 941193016475 MarR family; Region: MarR_2; cl17246 941193016476 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941193016477 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 941193016478 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 941193016479 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941193016480 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193016481 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 941193016482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193016483 putative substrate translocation pore; other site 941193016484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193016485 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 941193016486 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 941193016487 NAD binding site [chemical binding]; other site 941193016488 substrate binding site [chemical binding]; other site 941193016489 homodimer interface [polypeptide binding]; other site 941193016490 active site 941193016491 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 941193016492 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 941193016493 NADP binding site [chemical binding]; other site 941193016494 active site 941193016495 putative substrate binding site [chemical binding]; other site 941193016496 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 941193016497 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 941193016498 substrate binding site; other site 941193016499 tetramer interface; other site 941193016500 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 941193016501 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 941193016502 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193016503 dimer interface [polypeptide binding]; other site 941193016504 phosphorylation site [posttranslational modification] 941193016505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193016506 ATP binding site [chemical binding]; other site 941193016507 Mg2+ binding site [ion binding]; other site 941193016508 G-X-G motif; other site 941193016509 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 941193016510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193016511 active site 941193016512 phosphorylation site [posttranslational modification] 941193016513 intermolecular recognition site; other site 941193016514 dimerization interface [polypeptide binding]; other site 941193016515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193016516 Walker A motif; other site 941193016517 ATP binding site [chemical binding]; other site 941193016518 Walker B motif; other site 941193016519 arginine finger; other site 941193016520 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941193016521 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 941193016522 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 941193016523 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 941193016524 DctM-like transporters; Region: DctM; pfam06808 941193016525 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 941193016526 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 941193016527 arginine deiminase; Provisional; Region: PRK01388 941193016528 ornithine carbamoyltransferase; Validated; Region: PRK02102 941193016529 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 941193016530 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 941193016531 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 941193016532 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 941193016533 putative substrate binding site [chemical binding]; other site 941193016534 nucleotide binding site [chemical binding]; other site 941193016535 nucleotide binding site [chemical binding]; other site 941193016536 homodimer interface [polypeptide binding]; other site 941193016537 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 941193016538 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 941193016539 active site 941193016540 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 941193016541 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 941193016542 active site 941193016543 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 941193016544 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 941193016545 dimer interface [polypeptide binding]; other site 941193016546 ADP-ribose binding site [chemical binding]; other site 941193016547 active site 941193016548 nudix motif; other site 941193016549 metal binding site [ion binding]; metal-binding site 941193016550 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 941193016551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941193016552 motif II; other site 941193016553 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 941193016554 BON domain; Region: BON; pfam04972 941193016555 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941193016556 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193016557 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193016558 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941193016559 dimerization interface [polypeptide binding]; other site 941193016560 Uncharacterized protein required for formate dehydrogenase activity [Energy production and conversion]; Region: FdhD; COG1526 941193016561 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 941193016562 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 941193016563 putative molybdopterin cofactor binding site [chemical binding]; other site 941193016564 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 941193016565 putative molybdopterin cofactor binding site; other site 941193016566 Global regulator protein family; Region: CsrA; pfam02599 941193016567 chorismate mutase; Provisional; Region: PRK09269 941193016568 chorismate mutase, putative; Region: CM_mono2; TIGR01806 941193016569 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 941193016570 active site 941193016571 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 941193016572 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 941193016573 putative active site [active] 941193016574 metal binding site [ion binding]; metal-binding site 941193016575 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 941193016576 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 941193016577 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941193016578 active site 941193016579 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 941193016580 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 941193016581 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 941193016582 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 941193016583 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 941193016584 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941193016585 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193016586 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941193016587 dimerization interface [polypeptide binding]; other site 941193016588 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 941193016589 dimer interface [polypeptide binding]; other site 941193016590 FMN binding site [chemical binding]; other site 941193016591 Fimbrial protein; Region: Fimbrial; cl01416 941193016592 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 941193016593 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 941193016594 active site 941193016595 substrate-binding site [chemical binding]; other site 941193016596 metal-binding site [ion binding] 941193016597 ATP binding site [chemical binding]; other site 941193016598 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 941193016599 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 941193016600 dimerization interface [polypeptide binding]; other site 941193016601 domain crossover interface; other site 941193016602 redox-dependent activation switch; other site 941193016603 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 941193016604 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 941193016605 active site 941193016606 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941193016607 RNA binding surface [nucleotide binding]; other site 941193016608 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 941193016609 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 941193016610 RimK-like ATP-grasp domain; Region: RimK; pfam08443 941193016611 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 941193016612 dimer interface [polypeptide binding]; other site 941193016613 catalytic triad [active] 941193016614 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 941193016615 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193016616 dimerization interface [polypeptide binding]; other site 941193016617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193016618 ATP binding site [chemical binding]; other site 941193016619 Mg2+ binding site [ion binding]; other site 941193016620 G-X-G motif; other site 941193016621 osmolarity response regulator; Provisional; Region: ompR; PRK09468 941193016622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193016623 active site 941193016624 phosphorylation site [posttranslational modification] 941193016625 intermolecular recognition site; other site 941193016626 dimerization interface [polypeptide binding]; other site 941193016627 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193016628 DNA binding site [nucleotide binding] 941193016629 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 941193016630 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 941193016631 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 941193016632 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 941193016633 RNA binding site [nucleotide binding]; other site 941193016634 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 941193016635 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 941193016636 CoenzymeA binding site [chemical binding]; other site 941193016637 subunit interaction site [polypeptide binding]; other site 941193016638 PHB binding site; other site 941193016639 glutamate--cysteine ligase; Provisional; Region: PRK02107 941193016640 N-acetylglutamate synthase; Validated; Region: PRK05279 941193016641 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 941193016642 putative feedback inhibition sensing region; other site 941193016643 putative nucleotide binding site [chemical binding]; other site 941193016644 putative substrate binding site [chemical binding]; other site 941193016645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941193016646 Coenzyme A binding pocket [chemical binding]; other site 941193016647 inner membrane protein; Provisional; Region: PRK10995 941193016648 acetylornithine deacetylase; Provisional; Region: PRK05111 941193016649 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 941193016650 metal binding site [ion binding]; metal-binding site 941193016651 putative dimer interface [polypeptide binding]; other site 941193016652 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 941193016653 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 941193016654 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 941193016655 Uncharacterized conserved protein [Function unknown]; Region: COG3025 941193016656 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 941193016657 putative active site [active] 941193016658 putative metal binding residues [ion binding]; other site 941193016659 signature motif; other site 941193016660 putative triphosphate binding site [ion binding]; other site 941193016661 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 941193016662 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 941193016663 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 941193016664 Walker A motif; other site 941193016665 ATP binding site [chemical binding]; other site 941193016666 Walker B motif; other site 941193016667 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 941193016668 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 941193016669 glycine dehydrogenase; Provisional; Region: PRK12566 941193016670 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941193016671 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941193016672 catalytic residue [active] 941193016673 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 941193016674 tetramer interface [polypeptide binding]; other site 941193016675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193016676 catalytic residue [active] 941193016677 glycine cleavage system protein H; Provisional; Region: PRK13380 941193016678 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 941193016679 lipoyl attachment site [posttranslational modification]; other site 941193016680 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 941193016681 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 941193016682 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 941193016683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193016684 dimer interface [polypeptide binding]; other site 941193016685 conserved gate region; other site 941193016686 putative PBP binding loops; other site 941193016687 ABC-ATPase subunit interface; other site 941193016688 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 941193016689 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 941193016690 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 941193016691 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193016692 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 941193016693 dimerization interface [polypeptide binding]; other site 941193016694 substrate binding pocket [chemical binding]; other site 941193016695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193016696 putative substrate translocation pore; other site 941193016697 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941193016698 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714 941193016699 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 941193016700 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 941193016701 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 941193016702 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 941193016703 proline aminopeptidase P II; Provisional; Region: PRK10879 941193016704 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 941193016705 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 941193016706 active site 941193016707 hypothetical protein; Reviewed; Region: PRK02166 941193016708 TIGR02449 family protein; Region: TIGR02449 941193016709 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 941193016710 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 941193016711 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 941193016712 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 941193016713 Uncharacterized conserved protein [Function unknown]; Region: COG2947 941193016714 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 941193016715 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 941193016716 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 941193016717 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 941193016718 Walker A/P-loop; other site 941193016719 ATP binding site [chemical binding]; other site 941193016720 Q-loop/lid; other site 941193016721 ABC transporter signature motif; other site 941193016722 Walker B; other site 941193016723 D-loop; other site 941193016724 H-loop/switch region; other site 941193016725 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 941193016726 Walker A/P-loop; other site 941193016727 ATP binding site [chemical binding]; other site 941193016728 Q-loop/lid; other site 941193016729 ABC transporter signature motif; other site 941193016730 Walker B; other site 941193016731 D-loop; other site 941193016732 H-loop/switch region; other site 941193016733 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 941193016734 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 941193016735 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 941193016736 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 941193016737 HlyD family secretion protein; Region: HlyD_3; pfam13437 941193016738 flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697 941193016739 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 941193016740 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 941193016741 NAD(P) binding site [chemical binding]; other site 941193016742 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 941193016743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193016744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193016745 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 941193016746 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941193016747 catalytic loop [active] 941193016748 iron binding site [ion binding]; other site 941193016749 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 941193016750 FAD binding pocket [chemical binding]; other site 941193016751 FAD binding motif [chemical binding]; other site 941193016752 phosphate binding motif [ion binding]; other site 941193016753 beta-alpha-beta structure motif; other site 941193016754 NAD binding pocket [chemical binding]; other site 941193016755 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 941193016756 Acyltransferase family; Region: Acyl_transf_3; pfam01757 941193016757 transcription termination factor Rho; Provisional; Region: rho; PRK09376 941193016758 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 941193016759 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 941193016760 RNA binding site [nucleotide binding]; other site 941193016761 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 941193016762 multimer interface [polypeptide binding]; other site 941193016763 Walker A motif; other site 941193016764 ATP binding site [chemical binding]; other site 941193016765 Walker B motif; other site 941193016766 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 941193016767 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 941193016768 catalytic residues [active] 941193016769 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 941193016770 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 941193016771 polyphosphate kinase; Provisional; Region: PRK05443 941193016772 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 941193016773 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 941193016774 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 941193016775 putative domain interface [polypeptide binding]; other site 941193016776 putative active site [active] 941193016777 catalytic site [active] 941193016778 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 941193016779 putative domain interface [polypeptide binding]; other site 941193016780 putative active site [active] 941193016781 catalytic site [active] 941193016782 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 941193016783 dimer interface [polypeptide binding]; other site 941193016784 active site 941193016785 aspartate-rich active site metal binding site; other site 941193016786 allosteric magnesium binding site [ion binding]; other site 941193016787 Schiff base residues; other site 941193016788 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 941193016789 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 941193016790 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 941193016791 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 941193016792 conserved cys residue [active] 941193016793 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 941193016794 CoenzymeA binding site [chemical binding]; other site 941193016795 subunit interaction site [polypeptide binding]; other site 941193016796 PHB binding site; other site 941193016797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 941193016798 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 941193016799 Cytochrome c; Region: Cytochrom_C; pfam00034 941193016800 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 941193016801 LysE type translocator; Region: LysE; cl00565 941193016802 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 941193016803 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 941193016804 Mechanosensitive ion channel; Region: MS_channel; pfam00924 941193016805 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 941193016806 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193016807 Walker A/P-loop; other site 941193016808 ATP binding site [chemical binding]; other site 941193016809 Q-loop/lid; other site 941193016810 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941193016811 ABC transporter; Region: ABC_tran_2; pfam12848 941193016812 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941193016813 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 941193016814 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 941193016815 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 941193016816 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 941193016817 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 941193016818 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 941193016819 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 941193016820 HemY protein N-terminus; Region: HemY_N; pfam07219 941193016821 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941193016822 binding surface 941193016823 TPR motif; other site 941193016824 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 941193016825 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 941193016826 uroporphyrinogen-III synthase; Validated; Region: PRK05752 941193016827 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 941193016828 active site 941193016829 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 941193016830 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 941193016831 domain interfaces; other site 941193016832 active site 941193016833 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 941193016834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193016835 active site 941193016836 phosphorylation site [posttranslational modification] 941193016837 intermolecular recognition site; other site 941193016838 dimerization interface [polypeptide binding]; other site 941193016839 LytTr DNA-binding domain; Region: LytTR; pfam04397 941193016840 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 941193016841 Histidine kinase; Region: His_kinase; pfam06580 941193016842 argininosuccinate lyase; Provisional; Region: PRK00855 941193016843 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 941193016844 active sites [active] 941193016845 tetramer interface [polypeptide binding]; other site 941193016846 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 941193016847 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 941193016848 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 941193016849 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 941193016850 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 941193016851 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 941193016852 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 941193016853 Cl binding site [ion binding]; other site 941193016854 oligomer interface [polypeptide binding]; other site 941193016855 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 941193016856 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193016857 substrate binding pocket [chemical binding]; other site 941193016858 membrane-bound complex binding site; other site 941193016859 hinge residues; other site 941193016860 TIGR02647 family protein; Region: DNA 941193016861 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 941193016862 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 941193016863 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 941193016864 Uncharacterized conserved protein [Function unknown]; Region: COG4278 941193016865 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 941193016866 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 941193016867 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 941193016868 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 941193016869 putative iron binding site [ion binding]; other site 941193016870 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 941193016871 diaminopimelate decarboxylase; Region: lysA; TIGR01048 941193016872 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 941193016873 active site 941193016874 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941193016875 substrate binding site [chemical binding]; other site 941193016876 catalytic residues [active] 941193016877 dimer interface [polypeptide binding]; other site 941193016878 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 941193016879 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 941193016880 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 941193016881 Protein of unknown function, DUF484; Region: DUF484; pfam04340 941193016882 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 941193016883 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 941193016884 active site 941193016885 DNA binding site [nucleotide binding] 941193016886 Int/Topo IB signature motif; other site 941193016887 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 941193016888 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941193016889 motif II; other site 941193016890 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 941193016891 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193016892 DNA-binding site [nucleotide binding]; DNA binding site 941193016893 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941193016894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193016895 homodimer interface [polypeptide binding]; other site 941193016896 catalytic residue [active] 941193016897 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 941193016898 Uncharacterized conserved protein [Function unknown]; Region: COG0432 941193016899 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 941193016900 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 941193016901 Nitrogen regulatory protein P-II; Region: P-II; smart00938 941193016902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 941193016903 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 941193016904 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 941193016905 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 941193016906 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 941193016907 BCCT family transporter; Region: BCCT; cl00569 941193016908 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 941193016909 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 941193016910 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193016911 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 941193016912 dimerization interface [polypeptide binding]; other site 941193016913 substrate binding pocket [chemical binding]; other site 941193016914 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193016915 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193016916 metal binding site [ion binding]; metal-binding site 941193016917 active site 941193016918 I-site; other site 941193016919 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941193016920 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 941193016921 Part of AAA domain; Region: AAA_19; pfam13245 941193016922 Family description; Region: UvrD_C_2; pfam13538 941193016923 pyruvate dehydrogenase; Provisional; Region: PRK09124 941193016924 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 941193016925 PYR/PP interface [polypeptide binding]; other site 941193016926 dimer interface [polypeptide binding]; other site 941193016927 tetramer interface [polypeptide binding]; other site 941193016928 TPP binding site [chemical binding]; other site 941193016929 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 941193016930 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 941193016931 TPP-binding site [chemical binding]; other site 941193016932 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941193016933 active site 941193016934 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 941193016935 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 941193016936 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 941193016937 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 941193016938 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941193016939 non-specific DNA binding site [nucleotide binding]; other site 941193016940 salt bridge; other site 941193016941 sequence-specific DNA binding site [nucleotide binding]; other site 941193016942 Cupin domain; Region: Cupin_2; pfam07883 941193016943 alanine racemase; Reviewed; Region: dadX; PRK03646 941193016944 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 941193016945 active site 941193016946 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941193016947 substrate binding site [chemical binding]; other site 941193016948 catalytic residues [active] 941193016949 dimer interface [polypeptide binding]; other site 941193016950 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 941193016951 homotrimer interaction site [polypeptide binding]; other site 941193016952 putative active site [active] 941193016953 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 941193016954 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 941193016955 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 941193016956 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 941193016957 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 941193016958 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941193016959 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941193016960 putative DNA binding site [nucleotide binding]; other site 941193016961 putative Zn2+ binding site [ion binding]; other site 941193016962 AsnC family; Region: AsnC_trans_reg; pfam01037 941193016963 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 941193016964 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 941193016965 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 941193016966 PLD-like domain; Region: PLDc_2; pfam13091 941193016967 putative active site [active] 941193016968 catalytic site [active] 941193016969 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 941193016970 PLD-like domain; Region: PLDc_2; pfam13091 941193016971 putative active site [active] 941193016972 catalytic site [active] 941193016973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193016974 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941193016975 putative substrate translocation pore; other site 941193016976 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 941193016977 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 941193016978 NAD(P) binding site [chemical binding]; other site 941193016979 catalytic residues [active] 941193016980 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 941193016981 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941193016982 inhibitor-cofactor binding pocket; inhibition site 941193016983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193016984 catalytic residue [active] 941193016985 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 941193016986 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 941193016987 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 941193016988 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 941193016989 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 941193016990 peptide binding site [polypeptide binding]; other site 941193016991 hypothetical protein; Reviewed; Region: PRK00024 941193016992 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 941193016993 MPN+ (JAMM) motif; other site 941193016994 Zinc-binding site [ion binding]; other site 941193016995 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 941193016996 Flavoprotein; Region: Flavoprotein; pfam02441 941193016997 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 941193016998 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 941193016999 trimer interface [polypeptide binding]; other site 941193017000 active site 941193017001 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 941193017002 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 941193017003 active site 941193017004 substrate binding site [chemical binding]; other site 941193017005 metal binding site [ion binding]; metal-binding site 941193017006 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 941193017007 feedback inhibition sensing region; other site 941193017008 homohexameric interface [polypeptide binding]; other site 941193017009 nucleotide binding site [chemical binding]; other site 941193017010 N-acetyl-L-glutamate binding site [chemical binding]; other site 941193017011 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 941193017012 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941193017013 SurA N-terminal domain; Region: SurA_N; pfam09312 941193017014 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193017015 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 941193017016 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 941193017017 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 3; Region: PLPDE_III_DSD_D-TA_like_3; cd06814 941193017018 dimer interface [polypeptide binding]; other site 941193017019 active site 941193017020 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941193017021 substrate binding site [chemical binding]; other site 941193017022 catalytic residue [active] 941193017023 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 941193017024 FAD binding domain; Region: FAD_binding_4; pfam01565 941193017025 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 941193017026 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 941193017027 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 941193017028 active site 941193017029 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941193017030 active site 941193017031 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 941193017032 putative active site [active] 941193017033 putative catalytic site [active] 941193017034 putative DNA binding site [nucleotide binding]; other site 941193017035 putative phosphate binding site [ion binding]; other site 941193017036 metal binding site A [ion binding]; metal-binding site 941193017037 putative AP binding site [nucleotide binding]; other site 941193017038 putative metal binding site B [ion binding]; other site 941193017039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 941193017040 ribonuclease PH; Reviewed; Region: rph; PRK00173 941193017041 Ribonuclease PH; Region: RNase_PH_bact; cd11362 941193017042 hexamer interface [polypeptide binding]; other site 941193017043 active site 941193017044 hypothetical protein; Provisional; Region: PRK11820 941193017045 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 941193017046 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 941193017047 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 941193017048 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 941193017049 catalytic site [active] 941193017050 G-X2-G-X-G-K; other site 941193017051 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 941193017052 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 941193017053 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941193017054 Zn2+ binding site [ion binding]; other site 941193017055 Mg2+ binding site [ion binding]; other site 941193017056 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 941193017057 synthetase active site [active] 941193017058 NTP binding site [chemical binding]; other site 941193017059 metal binding site [ion binding]; metal-binding site 941193017060 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 941193017061 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 941193017062 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 941193017063 homotrimer interaction site [polypeptide binding]; other site 941193017064 putative active site [active] 941193017065 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 941193017066 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 941193017067 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941193017068 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193017069 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 941193017070 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 941193017071 putative NAD(P) binding site [chemical binding]; other site 941193017072 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 941193017073 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193017074 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 941193017075 dimerization interface [polypeptide binding]; other site 941193017076 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 941193017077 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 941193017078 ssDNA binding site; other site 941193017079 generic binding surface II; other site 941193017080 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941193017081 ATP binding site [chemical binding]; other site 941193017082 putative Mg++ binding site [ion binding]; other site 941193017083 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941193017084 nucleotide binding region [chemical binding]; other site 941193017085 ATP-binding site [chemical binding]; other site 941193017086 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 941193017087 putative deacylase active site [active] 941193017088 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 941193017089 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 941193017090 IHF dimer interface [polypeptide binding]; other site 941193017091 IHF - DNA interface [nucleotide binding]; other site 941193017092 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 941193017093 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941193017094 Rubredoxin [Energy production and conversion]; Region: COG1773 941193017095 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 941193017096 iron binding site [ion binding]; other site 941193017097 Rubredoxin [Energy production and conversion]; Region: COG1773 941193017098 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 941193017099 iron binding site [ion binding]; other site 941193017100 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 941193017101 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 941193017102 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 941193017103 Cysteine-rich domain; Region: CCG; pfam02754 941193017104 Cysteine-rich domain; Region: CCG; pfam02754 941193017105 FAD binding domain; Region: FAD_binding_4; pfam01565 941193017106 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 941193017107 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 941193017108 FAD binding domain; Region: FAD_binding_4; pfam01565 941193017109 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 941193017110 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193017111 DNA-binding site [nucleotide binding]; DNA binding site 941193017112 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 941193017113 Chorismate lyase; Region: Chor_lyase; pfam04345 941193017114 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 941193017115 UbiA prenyltransferase family; Region: UbiA; pfam01040 941193017116 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 941193017117 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 941193017118 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 941193017119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193017120 active site 941193017121 phosphorylation site [posttranslational modification] 941193017122 intermolecular recognition site; other site 941193017123 dimerization interface [polypeptide binding]; other site 941193017124 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941193017125 DNA binding site [nucleotide binding] 941193017126 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 941193017127 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 941193017128 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193017129 putative active site [active] 941193017130 heme pocket [chemical binding]; other site 941193017131 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193017132 dimer interface [polypeptide binding]; other site 941193017133 phosphorylation site [posttranslational modification] 941193017134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193017135 ATP binding site [chemical binding]; other site 941193017136 Mg2+ binding site [ion binding]; other site 941193017137 G-X-G motif; other site 941193017138 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 941193017139 Domain of unknown function DUF21; Region: DUF21; pfam01595 941193017140 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 941193017141 Transporter associated domain; Region: CorC_HlyC; smart01091 941193017142 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 941193017143 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 941193017144 Peptidase family M23; Region: Peptidase_M23; pfam01551 941193017145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193017146 Response regulator receiver domain; Region: Response_reg; pfam00072 941193017147 active site 941193017148 phosphorylation site [posttranslational modification] 941193017149 intermolecular recognition site; other site 941193017150 dimerization interface [polypeptide binding]; other site 941193017151 transcriptional regulator PhoU; Provisional; Region: PRK11115 941193017152 PhoU domain; Region: PhoU; pfam01895 941193017153 PhoU domain; Region: PhoU; pfam01895 941193017154 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 941193017155 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 941193017156 Walker A/P-loop; other site 941193017157 ATP binding site [chemical binding]; other site 941193017158 Q-loop/lid; other site 941193017159 ABC transporter signature motif; other site 941193017160 Walker B; other site 941193017161 D-loop; other site 941193017162 H-loop/switch region; other site 941193017163 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 941193017164 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 941193017165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193017166 dimer interface [polypeptide binding]; other site 941193017167 conserved gate region; other site 941193017168 putative PBP binding loops; other site 941193017169 ABC-ATPase subunit interface; other site 941193017170 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 941193017171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193017172 ABC-ATPase subunit interface; other site 941193017173 PBP superfamily domain; Region: PBP_like_2; cl17296 941193017174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193017175 metabolite-proton symporter; Region: 2A0106; TIGR00883 941193017176 putative substrate translocation pore; other site 941193017177 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 941193017178 choline dehydrogenase; Validated; Region: PRK02106 941193017179 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 941193017180 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 941193017181 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 941193017182 tetrameric interface [polypeptide binding]; other site 941193017183 NAD binding site [chemical binding]; other site 941193017184 catalytic residues [active] 941193017185 transcriptional regulator BetI; Validated; Region: PRK00767 941193017186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941193017187 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 941193017188 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 941193017189 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 941193017190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941193017191 Walker A/P-loop; other site 941193017192 ATP binding site [chemical binding]; other site 941193017193 Q-loop/lid; other site 941193017194 ABC transporter signature motif; other site 941193017195 Walker B; other site 941193017196 D-loop; other site 941193017197 H-loop/switch region; other site 941193017198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193017199 dimer interface [polypeptide binding]; other site 941193017200 conserved gate region; other site 941193017201 putative PBP binding loops; other site 941193017202 ABC-ATPase subunit interface; other site 941193017203 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 941193017204 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 941193017205 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 941193017206 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 941193017207 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 941193017208 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 941193017209 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 941193017210 conserved cys residue [active] 941193017211 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941193017212 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 941193017213 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193017214 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 941193017215 putative dimerization interface [polypeptide binding]; other site 941193017216 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 941193017217 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 941193017218 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 941193017219 active site 941193017220 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 941193017221 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 941193017222 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 941193017223 Uncharacterized conserved protein [Function unknown]; Region: COG3246 941193017224 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 941193017225 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 941193017226 acetylornithine deacetylase; Provisional; Region: PRK07522 941193017227 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 941193017228 metal binding site [ion binding]; metal-binding site 941193017229 putative dimer interface [polypeptide binding]; other site 941193017230 Uncharacterized conserved protein [Function unknown]; Region: COG3342 941193017231 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 941193017232 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 941193017233 homotrimer interaction site [polypeptide binding]; other site 941193017234 putative active site [active] 941193017235 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941193017236 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 941193017237 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 941193017238 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 941193017239 putative active site [active] 941193017240 catalytic site [active] 941193017241 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 941193017242 putative active site [active] 941193017243 catalytic site [active] 941193017244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 941193017245 SnoaL-like domain; Region: SnoaL_2; pfam12680 941193017246 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 941193017247 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 941193017248 active site 941193017249 V4R domain; Region: V4R; cl15268 941193017250 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 941193017251 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 941193017252 putative active site [active] 941193017253 putative FMN binding site [chemical binding]; other site 941193017254 putative substrate binding site [chemical binding]; other site 941193017255 putative catalytic residue [active] 941193017256 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941193017257 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 941193017258 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 941193017259 Cysteine-rich domain; Region: CCG; pfam02754 941193017260 Cysteine-rich domain; Region: CCG; pfam02754 941193017261 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 941193017262 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 941193017263 Ligand Binding Site [chemical binding]; other site 941193017264 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 941193017265 Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086 941193017266 Ligand Binding Site [chemical binding]; other site 941193017267 Electron transfer flavoprotein domain; Region: ETF; pfam01012 941193017268 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 941193017269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941193017270 non-specific DNA binding site [nucleotide binding]; other site 941193017271 salt bridge; other site 941193017272 sequence-specific DNA binding site [nucleotide binding]; other site 941193017273 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 941193017274 Cell division protein ZapA; Region: ZapA; pfam05164 941193017275 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 941193017276 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 941193017277 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 941193017278 [2Fe-2S] cluster binding site [ion binding]; other site 941193017279 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 941193017280 putative alpha subunit interface [polypeptide binding]; other site 941193017281 putative active site [active] 941193017282 putative substrate binding site [chemical binding]; other site 941193017283 Fe binding site [ion binding]; other site 941193017284 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 941193017285 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 941193017286 FAD binding pocket [chemical binding]; other site 941193017287 FAD binding motif [chemical binding]; other site 941193017288 phosphate binding motif [ion binding]; other site 941193017289 beta-alpha-beta structure motif; other site 941193017290 NAD binding pocket [chemical binding]; other site 941193017291 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941193017292 catalytic loop [active] 941193017293 iron binding site [ion binding]; other site 941193017294 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 941193017295 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 941193017296 tetramer interface [polypeptide binding]; other site 941193017297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193017298 catalytic residue [active] 941193017299 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 941193017300 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 941193017301 dimer interface [polypeptide binding]; other site 941193017302 active site 941193017303 glycine-pyridoxal phosphate binding site [chemical binding]; other site 941193017304 folate binding site [chemical binding]; other site 941193017305 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 941193017306 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 941193017307 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 941193017308 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 941193017309 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 941193017310 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 941193017311 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 941193017312 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 941193017313 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 941193017314 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 941193017315 putative active site [active] 941193017316 putative substrate binding site [chemical binding]; other site 941193017317 putative cosubstrate binding site; other site 941193017318 catalytic site [active] 941193017319 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 941193017320 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 941193017321 NAD binding site [chemical binding]; other site 941193017322 catalytic Zn binding site [ion binding]; other site 941193017323 structural Zn binding site [ion binding]; other site 941193017324 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 941193017325 active site 941193017326 phosphate binding residues; other site 941193017327 catalytic residues [active] 941193017328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3495 941193017329 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 941193017330 ATP-grasp domain; Region: ATP-grasp; pfam02222 941193017331 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 941193017332 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 941193017333 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 941193017334 NAD binding site [chemical binding]; other site 941193017335 substrate binding site [chemical binding]; other site 941193017336 catalytic Zn binding site [ion binding]; other site 941193017337 tetramer interface [polypeptide binding]; other site 941193017338 structural Zn binding site [ion binding]; other site 941193017339 cell density-dependent motility repressor; Provisional; Region: PRK10082 941193017340 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193017341 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941193017342 dimerization interface [polypeptide binding]; other site 941193017343 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 941193017344 Aspartase; Region: Aspartase; cd01357 941193017345 active sites [active] 941193017346 tetramer interface [polypeptide binding]; other site 941193017347 Sulphur transport; Region: Sulf_transp; pfam04143 941193017348 Predicted transporter component [General function prediction only]; Region: COG2391 941193017349 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 941193017350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193017351 DNA-binding site [nucleotide binding]; DNA binding site 941193017352 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941193017353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193017354 homodimer interface [polypeptide binding]; other site 941193017355 catalytic residue [active] 941193017356 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 941193017357 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 941193017358 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 941193017359 tryptophan permease; Provisional; Region: PRK10483 941193017360 aromatic amino acid transport protein; Region: araaP; TIGR00837 941193017361 pyruvate carboxylase subunit B; Validated; Region: PRK09282 941193017362 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 941193017363 active site 941193017364 catalytic residues [active] 941193017365 metal binding site [ion binding]; metal-binding site 941193017366 homodimer binding site [polypeptide binding]; other site 941193017367 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 941193017368 carboxyltransferase (CT) interaction site; other site 941193017369 biotinylation site [posttranslational modification]; other site 941193017370 pyruvate carboxylase subunit A; Validated; Region: PRK07178 941193017371 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 941193017372 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 941193017373 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 941193017374 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 941193017375 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941193017376 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 941193017377 putative dimerization interface [polypeptide binding]; other site 941193017378 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 941193017379 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 941193017380 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 941193017381 putative active site [active] 941193017382 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 941193017383 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 941193017384 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 941193017385 putative protease; Provisional; Region: PRK15452 941193017386 Peptidase family U32; Region: Peptidase_U32; pfam01136 941193017387 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 941193017388 PAS fold; Region: PAS_3; pfam08447 941193017389 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193017390 heme pocket [chemical binding]; other site 941193017391 putative active site [active] 941193017392 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193017393 PAS domain; Region: PAS_9; pfam13426 941193017394 putative active site [active] 941193017395 heme pocket [chemical binding]; other site 941193017396 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193017397 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193017398 metal binding site [ion binding]; metal-binding site 941193017399 active site 941193017400 I-site; other site 941193017401 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941193017402 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 941193017403 Part of AAA domain; Region: AAA_19; pfam13245 941193017404 Family description; Region: UvrD_C_2; pfam13538 941193017405 Predicted membrane protein [Function unknown]; Region: COG2510 941193017406 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 941193017407 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 941193017408 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 941193017409 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 941193017410 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941193017411 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 941193017412 putative ADP-binding pocket [chemical binding]; other site 941193017413 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 941193017414 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941193017415 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 941193017416 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941193017417 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 941193017418 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 941193017419 Walker A/P-loop; other site 941193017420 ATP binding site [chemical binding]; other site 941193017421 Q-loop/lid; other site 941193017422 ABC transporter signature motif; other site 941193017423 Walker B; other site 941193017424 D-loop; other site 941193017425 H-loop/switch region; other site 941193017426 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 941193017427 putative carbohydrate binding site [chemical binding]; other site 941193017428 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 941193017429 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 941193017430 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 941193017431 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 941193017432 Substrate binding site; other site 941193017433 Cupin domain; Region: Cupin_2; cl17218 941193017434 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 941193017435 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 941193017436 NADP-binding site; other site 941193017437 homotetramer interface [polypeptide binding]; other site 941193017438 substrate binding site [chemical binding]; other site 941193017439 homodimer interface [polypeptide binding]; other site 941193017440 active site 941193017441 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 941193017442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193017443 NAD(P) binding site [chemical binding]; other site 941193017444 active site 941193017445 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941193017446 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 941193017447 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 941193017448 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941193017449 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 941193017450 Methyltransferase domain; Region: Methyltransf_31; pfam13847 941193017451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193017452 S-adenosylmethionine binding site [chemical binding]; other site 941193017453 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 941193017454 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 941193017455 Methyltransferase domain; Region: Methyltransf_11; pfam08241 941193017456 conserverd hypothetical protein; Region: TIGR02448 941193017457 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 941193017458 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 941193017459 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 941193017460 Uncharacterized conserved protein [Function unknown]; Region: COG3791 941193017461 Predicted permeases [General function prediction only]; Region: COG0679 941193017462 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 941193017463 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 941193017464 Citrate transporter; Region: CitMHS; pfam03600 941193017465 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 941193017466 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 941193017467 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 941193017468 hypothetical protein; Reviewed; Region: PRK09588 941193017469 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 941193017470 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 941193017471 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 941193017472 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 941193017473 PhoU domain; Region: PhoU; pfam01895 941193017474 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 941193017475 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 941193017476 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 941193017477 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 941193017478 citrate-proton symporter; Provisional; Region: PRK15075 941193017479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193017480 putative substrate translocation pore; other site 941193017481 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 941193017482 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 941193017483 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 941193017484 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 941193017485 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 941193017486 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 941193017487 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 941193017488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193017489 active site 941193017490 phosphorylation site [posttranslational modification] 941193017491 intermolecular recognition site; other site 941193017492 dimerization interface [polypeptide binding]; other site 941193017493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193017494 Walker A motif; other site 941193017495 ATP binding site [chemical binding]; other site 941193017496 Walker B motif; other site 941193017497 arginine finger; other site 941193017498 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941193017499 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941193017500 dimerization interface [polypeptide binding]; other site 941193017501 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 941193017502 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941193017503 putative active site [active] 941193017504 heme pocket [chemical binding]; other site 941193017505 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193017506 dimer interface [polypeptide binding]; other site 941193017507 phosphorylation site [posttranslational modification] 941193017508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193017509 ATP binding site [chemical binding]; other site 941193017510 Mg2+ binding site [ion binding]; other site 941193017511 G-X-G motif; other site 941193017512 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 941193017513 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 941193017514 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 941193017515 amidase catalytic site [active] 941193017516 Zn binding residues [ion binding]; other site 941193017517 substrate binding site [chemical binding]; other site 941193017518 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 941193017519 MarC family integral membrane protein; Region: MarC; cl00919 941193017520 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941193017521 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941193017522 metal binding site [ion binding]; metal-binding site 941193017523 active site 941193017524 I-site; other site 941193017525 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 941193017526 putative catalytic site [active] 941193017527 putative metal binding site [ion binding]; other site 941193017528 putative phosphate binding site [ion binding]; other site 941193017529 putative catalytic site [active] 941193017530 putative phosphate binding site [ion binding]; other site 941193017531 putative metal binding site [ion binding]; other site 941193017532 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 941193017533 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 941193017534 catalytic residues [active] 941193017535 hinge region; other site 941193017536 alpha helical domain; other site 941193017537 Cytochrome c553 [Energy production and conversion]; Region: COG2863 941193017538 Cytochrome c; Region: Cytochrom_C; cl11414 941193017539 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 941193017540 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 941193017541 G1 box; other site 941193017542 GTP/Mg2+ binding site [chemical binding]; other site 941193017543 Switch I region; other site 941193017544 G2 box; other site 941193017545 G3 box; other site 941193017546 Switch II region; other site 941193017547 G4 box; other site 941193017548 G5 box; other site 941193017549 DNA polymerase I; Provisional; Region: PRK05755 941193017550 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 941193017551 active site 941193017552 metal binding site 1 [ion binding]; metal-binding site 941193017553 putative 5' ssDNA interaction site; other site 941193017554 metal binding site 3; metal-binding site 941193017555 metal binding site 2 [ion binding]; metal-binding site 941193017556 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 941193017557 putative DNA binding site [nucleotide binding]; other site 941193017558 putative metal binding site [ion binding]; other site 941193017559 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 941193017560 active site 941193017561 catalytic site [active] 941193017562 substrate binding site [chemical binding]; other site 941193017563 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 941193017564 active site 941193017565 DNA binding site [nucleotide binding] 941193017566 catalytic site [active] 941193017567 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 941193017568 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 941193017569 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 941193017570 putative active site [active] 941193017571 putative substrate binding site [chemical binding]; other site 941193017572 ATP binding site [chemical binding]; other site 941193017573 Ribonucleotide reductase, alpha subunit [Nucleotide transport and metabolism]; Region: NrdA; COG0209 941193017574 TSCPD domain; Region: TSCPD; pfam12637 941193017575 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 941193017576 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 941193017577 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 941193017578 active site 941193017579 dimer interface [polypeptide binding]; other site 941193017580 effector binding site; other site 941193017581 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 941193017582 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 941193017583 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 941193017584 metal binding site [ion binding]; metal-binding site 941193017585 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 941193017586 Predicted transcriptional regulators [Transcription]; Region: COG1695 941193017587 metal binding site 2 [ion binding]; metal-binding site 941193017588 putative DNA binding helix; other site 941193017589 metal binding site 1 [ion binding]; metal-binding site 941193017590 dimer interface [polypeptide binding]; other site 941193017591 structural Zn2+ binding site [ion binding]; other site 941193017592 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 941193017593 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 941193017594 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 941193017595 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941193017596 dimer interface [polypeptide binding]; other site 941193017597 putative PBP binding regions; other site 941193017598 ABC-ATPase subunit interface; other site 941193017599 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 941193017600 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 941193017601 Walker A/P-loop; other site 941193017602 ATP binding site [chemical binding]; other site 941193017603 Q-loop/lid; other site 941193017604 ABC transporter signature motif; other site 941193017605 Walker B; other site 941193017606 D-loop; other site 941193017607 H-loop/switch region; other site 941193017608 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 941193017609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941193017610 dimer interface [polypeptide binding]; other site 941193017611 conserved gate region; other site 941193017612 ABC-ATPase subunit interface; other site 941193017613 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 941193017614 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 941193017615 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 941193017616 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 941193017617 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 941193017618 putative active site [active] 941193017619 Isochorismatase family; Region: Isochorismatase; pfam00857 941193017620 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 941193017621 catalytic triad [active] 941193017622 conserved cis-peptide bond; other site 941193017623 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 941193017624 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 941193017625 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 941193017626 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 941193017627 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 941193017628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941193017629 active site 941193017630 phosphorylation site [posttranslational modification] 941193017631 intermolecular recognition site; other site 941193017632 dimerization interface [polypeptide binding]; other site 941193017633 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941193017634 Walker A motif; other site 941193017635 ATP binding site [chemical binding]; other site 941193017636 Walker B motif; other site 941193017637 arginine finger; other site 941193017638 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 941193017639 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 941193017640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941193017641 dimer interface [polypeptide binding]; other site 941193017642 phosphorylation site [posttranslational modification] 941193017643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941193017644 ATP binding site [chemical binding]; other site 941193017645 Mg2+ binding site [ion binding]; other site 941193017646 G-X-G motif; other site 941193017647 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 941193017648 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 941193017649 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 941193017650 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 941193017651 pyridoxamine kinase; Validated; Region: PRK05756 941193017652 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 941193017653 pyridoxal binding site [chemical binding]; other site 941193017654 dimer interface [polypeptide binding]; other site 941193017655 ATP binding site [chemical binding]; other site 941193017656 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 941193017657 Predicted membrane protein [Function unknown]; Region: COG1238 941193017658 putative cation:proton antiport protein; Provisional; Region: PRK10669 941193017659 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 941193017660 TrkA-N domain; Region: TrkA_N; pfam02254 941193017661 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 941193017662 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 941193017663 classical (c) SDRs; Region: SDR_c; cd05233 941193017664 NAD(P) binding site [chemical binding]; other site 941193017665 active site 941193017666 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 941193017667 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 941193017668 aminotransferase; Validated; Region: PRK07046 941193017669 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941193017670 inhibitor-cofactor binding pocket; inhibition site 941193017671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941193017672 catalytic residue [active] 941193017673 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 941193017674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941193017675 NAD(P) binding site [chemical binding]; other site 941193017676 active site 941193017677 Transcriptional regulators [Transcription]; Region: GntR; COG1802 941193017678 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941193017679 DNA-binding site [nucleotide binding]; DNA binding site 941193017680 FCD domain; Region: FCD; pfam07729 941193017681 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 941193017682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 941193017683 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 941193017684 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 941193017685 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 941193017686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193017687 putative substrate translocation pore; other site 941193017688 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 941193017689 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 941193017690 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 941193017691 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 941193017692 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 941193017693 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 941193017694 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 941193017695 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 941193017696 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 941193017697 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 941193017698 AMIN domain; Region: AMIN; pfam11741 941193017699 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 941193017700 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 941193017701 active site 941193017702 metal binding site [ion binding]; metal-binding site 941193017703 putative GTP cyclohydrolase; Provisional; Region: PRK13674 941193017704 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 941193017705 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 941193017706 trimer interface [polypeptide binding]; other site 941193017707 active site 941193017708 dihydroorotase; Reviewed; Region: PRK09236 941193017709 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 941193017710 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 941193017711 active site 941193017712 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 941193017713 Beta-lactamase; Region: Beta-lactamase; pfam00144 941193017714 Uncharacterized conserved protein [Function unknown]; Region: COG4729 941193017715 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 941193017716 DctM-like transporters; Region: DctM; pfam06808 941193017717 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 941193017718 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941193017719 substrate binding pocket [chemical binding]; other site 941193017720 membrane-bound complex binding site; other site 941193017721 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 941193017722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941193017723 S-adenosylmethionine binding site [chemical binding]; other site 941193017724 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 941193017725 Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; Region: HAD-SF-IB; TIGR01488 941193017726 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 941193017727 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 941193017728 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 941193017729 Cytochrome P450; Region: p450; cl12078 941193017730 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 941193017731 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 941193017732 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 941193017733 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 941193017734 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 941193017735 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 941193017736 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 941193017737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941193017738 putative substrate translocation pore; other site 941193017739 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 941193017740 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 941193017741 glutaminase active site [active] 941193017742 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 941193017743 dimer interface [polypeptide binding]; other site 941193017744 active site 941193017745 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 941193017746 dimer interface [polypeptide binding]; other site 941193017747 active site 941193017748 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 941193017749 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 941193017750 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 941193017751 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 941193017752 Peptidase family M23; Region: Peptidase_M23; pfam01551 941193017753 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 941193017754 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 941193017755 Substrate binding site; other site 941193017756 Mg++ binding site; other site 941193017757 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 941193017758 active site 941193017759 substrate binding site [chemical binding]; other site 941193017760 CoA binding site [chemical binding]; other site 941193017761 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 941193017762 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 941193017763 gamma subunit interface [polypeptide binding]; other site 941193017764 epsilon subunit interface [polypeptide binding]; other site 941193017765 LBP interface [polypeptide binding]; other site 941193017766 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 941193017767 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 941193017768 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 941193017769 alpha subunit interaction interface [polypeptide binding]; other site 941193017770 Walker A motif; other site 941193017771 ATP binding site [chemical binding]; other site 941193017772 Walker B motif; other site 941193017773 inhibitor binding site; inhibition site 941193017774 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 941193017775 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 941193017776 core domain interface [polypeptide binding]; other site 941193017777 delta subunit interface [polypeptide binding]; other site 941193017778 epsilon subunit interface [polypeptide binding]; other site 941193017779 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 941193017780 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 941193017781 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 941193017782 beta subunit interaction interface [polypeptide binding]; other site 941193017783 Walker A motif; other site 941193017784 ATP binding site [chemical binding]; other site 941193017785 Walker B motif; other site 941193017786 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 941193017787 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 941193017788 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 941193017789 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 941193017790 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 941193017791 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 941193017792 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 941193017793 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 941193017794 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 941193017795 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 941193017796 ParB-like nuclease domain; Region: ParBc; pfam02195 941193017797 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 941193017798 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 941193017799 P-loop; other site 941193017800 Magnesium ion binding site [ion binding]; other site 941193017801 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 941193017802 Magnesium ion binding site [ion binding]; other site 941193017803 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 941193017804 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 941193017805 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 941193017806 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 941193017807 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 941193017808 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 941193017809 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 941193017810 trmE is a tRNA modification GTPase; Region: trmE; cd04164 941193017811 G1 box; other site 941193017812 GTP/Mg2+ binding site [chemical binding]; other site 941193017813 Switch I region; other site 941193017814 G2 box; other site 941193017815 Switch II region; other site 941193017816 G3 box; other site 941193017817 G4 box; other site 941193017818 G5 box; other site 941193017819 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 941193017820 membrane protein insertase; Provisional; Region: PRK01318 941193017821 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 941193017822 ribonuclease P; Reviewed; Region: rnpA; PRK00396 941193017823 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399